Air Filtration Standards & Sustainability

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Air Filtration Standards & Sustainability Sean O Reilly Global Director Life Science Segment

HVAC Filter Types Filter Efficiency Energy Consumption Examples-LCC Terminal Housings & Hepa testing Hepa repair BIBO Housings HVAC & Hepa Standards CREO (Clean room design Software)

Camfil Group

Air Filtration Technologies

Types of HEPA Filters... Anodized Aluminum Frame 6 CAMFIL FARR 2013-05-04 Polyurethane Sealant Fiberglass or Thermoplastic Separator with adhesive Panel-type HEPA Microfiberglass HEPA media Gasket or Gel Seal Box-type HEPA Galvaneal or Stainless Steel Frame Aluminum Separator

7 The energy cost of ventilation (simplified) Cooling coil Heating coil Molecular-filter CAMFIL FARR 2013-05-04 OUTSIDE Pre-filter Secondary-filter Damper INSIDE Air supply Inlet duct FAN Distribution duct Air intake Air Handling Unit MOTOR Noise attenuation Room distribution grille

LCC - the increased cost of energy Typically 60-80% of the LCC of a filter is the energy consumption. 15 5 2 Filter Cost Labor Cost 8 Disposal Cost Cleaning Cost 70 Energy Cost What if we gave you free filters in exchange for 50% of your Energy savings?

Field Efficiency; Real Life Testing... Efficiency at 0.4 um (%) 80 70 60 50 40 30 MERV 13, fine fiber media MERV 13, coarse fiber media MERV 11, fine fiber media 9 CAMFIL FARR 2013-05-04 20 10 Apples to Apples in efficiency when doing an LCC analysis 0 0 500 1000 1500 2000 2500 3000 3500 4000 4500 5000 Life Time (h)

How does efficiency work... MERV 14/F8 Filter Camfil Durafil Fine Fiber Media Outside Air 1,500,000 Particles/ft 3 72% @ 0.3µm 72% @ 0.3µm Penetration Room Counts 420,000 Particles/ft 3 Coarse Fiber Media (Same type media used at Wyeth, prior to Camfil Farr) 25% @ 0.3µm Room Counts 1,125,000 Particles/ft 3

LCC & TCO Support Tools extraordinary Sales Tools

components of Life-Cycle Cost LCC = Investment + PC energy + PC maint. + PC cleaning + PC disposal Investment capital cost of filters, frames, installation PC energy present total cost of power PC maintenance present total cost of maintenance including filter replacement, etc. PC cleaning present cost of duct cleaning PC disposal present total cost for removal and disposal of the used filters

energy equation for life-cycle cost PC Energy the current cost of energy Energy (E) = [(Q * ΔP * T)/(ŋ * Co)] * Pc Q Air flow, m 3 /s (cfm) ΔP Average filter pressure loss, Pa (inwg) T Operation time, hr ŋ Fan efficiency, % Co Constant, 1000 in SI units, 8515 in IP units Pc Cost of Power, $/kwh

Camfil Design vs. Copy me Design Uniform radial style pleat loads evenly resulting, in lower average pressure drop and long loading curve. Chandler or V type pleat will blind causing rapid increase in pressure drop.

CAMFIL FARR 2013-05-04 16

and a Performance Comparison Easily compare stage by stage Complete LCC cost graph Includes all LCC reports and charts Writes a conclusion and recommendation for you Includes the explanations needed most 17 CAMFIL FARR 2013-05-04

Camfield Mobile Lab

Background to cleanroom ventilation Particles displaced Particles diluted Class 100 / ISO5 Class 10,000 / ISO7 & 100,000 / ISO8

Turbulent cleanroom ventilation a component of contamination control Clean air supply should dilute any residual particles shed from people and other emission sources and then be removed by the extract system Ventilation effectiveness defines how good the system is at diluting contamination and hence how much air is needed (ac/hr)

Ventilation Effectiveness key to successful contamination dilution Typical USA Air can also bounce off the floor and entrain contaminants

Ventilation Effectiveness key to successful contamination dilution Typical EU/Asia Cleaning could also be a concern

Pharmaseal G Standard for Life Science applications. Typical Model - 80% of Install Base

Fully Equipped for GMP In situ Controls Integrated Aerosol Dispersion Ring PAO Test Pressure Drop Airflow Velocity Hinged Grille Quick closing with ¼ Turn Fasteners Immediate access from room-side 100% Sampling Port Aerosol Injection Port

Pharmaseal: Long Term Security No Risks for Leaks During Life Cycle Airtight by Design Fully continuous welded. Airtight continuity with clean room ceiling with permanent trim standard design. Universal Knife Edge Housing Silicon gel (recommended). Immediate seal without mechanical strength. Gel belongs to filter. Expanded PU Gasket possible. Cleanroom False Ceiling Expanded PU Gel

factors influencing filter penetration 1. aerosol particle size different aerosols different generation techniques 2. aerosol concentration different generation techniques generator input conditions volume flow rate through filter 3. filtering velocity system conditions LEAKS

HEPA filters should be tested at the Most Penetrating Particle Size (MPPS) Example performance of a HEPA Filter 100.000 Viruses Droplet Nuclei Bacteria 99.998 0.12 micron Efficiency % 99.996 99.994 99.992 0.3 micron 99.990 99.988 0.01 0.1 1 Particle Size (µm) MPPS (0.16-0.2 micron) 31 CAMFIL FARR 2013-05-04

Room-Side Certification Control Panel - Centralized & Ergonomic: Injection + control from room-side requiring only 1 person to test filter. Quick plus airtight connection using the quick disconnect ports. Aerosol Dispersion Ring: PAO test performed in compliance with ISO-IEST standards. NO PAO IN HVAC DUCTING for fire safety & increased filter life.

Why is Room-Side Certification Important? How & where to use aerosol injection is often overlooked during the design process What location should aerosol be introduced? What type of terminal housing should an owner or engineer select & why? 1 2 1 2 3 AHU Injection? Ductwork Injection? Hood Injection? 3 4 RA Injection? 4

How to Test a WM Pharmaseal?

Products for Bio Safety / Life Science: BSL/Pharma/Nuclear Price Pharmatain NI Auto Scanning CamContain CS BSL/Pharma BSL/Pharma/Nuclear G CamSafe NI EFF /NI Maual Scan CamContain CL CamContain C NI Auto Scanning Camtain BIBO DC CamBox NI EFF/ NI Manual Scan BSL 1 No test BSL 2 BSL 2+3 BSL 3 BSL 3+4 Customer Value

CAMFIL FARR 2013-05-04 36

Current Standards-IEST (Cont.); Type E-AG1 Type K-Recommended for 0.01% leak test with thermal PAO

Current Standards EN1822 (Cont);

New Standard 2012; ISO -29463 parts 1 thru 5

Updated Cleanroom Filter Standards: CAMFIL FARR 2013-05-04 40

Updated Cleanroom Standards: CAMFIL FARR 2013-05-04 41 Simplify the classification process and if possible remove the need to evaluate the 95% UCL for 2-9 sample locations Review the classification procedure and make it more applicable to rooms in operation. The contamination isn t expected to be evenly distributed an assumption the current statistical approach makes. Avoid any radical changes to the principals of the current ISO cleanliness classes 1-9

HVAC Global Air Filter Standards CAMFIL FARR 2013-05-04 42

CREO a new CleanRoom design & Energy Optimization software.

CAMFIL FARR 04/05/2013 45