Ministero della Salute

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1 Ministro dlla Salut Dirzion Gnral Ricrca Sanitaria Biomdica dlla Vigilanza sugli Enti BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. CO PALMITOYLETHANOLAMIDE TO TARGET INFLAMMATION IN NEURODEGENERATIVE DISEASES: A STUDY FOCUSED ON PERIPHERAL IMMUNE CELLS SANTA LUCIA Bossù Paola Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT CO Gntic and functional prdictors of rspons to biologic thrapy in psoriasis. Lazio Costanzo Antonio Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun CO Dvlopmnt of slctiv inhibitors of crizotinib rsistant oncognic ALK kinas Lombardia Gambacorti Carlo Biomdica Oncology 2 Passrini Drug Discovry and Molcular Pharmacology DMP CO Idntification of novl biomarkrs of oocyts and mbryos comptnc by molcular analysis of apoptosis in cumulus oophorus clls and of mbryo scrtom: prdiction of Assistd Rproductiv Tchnology (ART) outcom Campania Colacurci Nicola Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F06 CO Dvlopmnt and optimization of a ddicatd systm for hyprthrmia tratmnt of patints with suprficial/smidpth tumours REGINA ELENA Strigari Lidia Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 1 di 356

2 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. CO Dvlopmnt and validation of nw assays for diagnosis and monitoring of infctious disass using th DiaSorin Q LAMP Tchnology SAN MATTEO BALDANTI FAUSTO Biomdica Infctious Disass and Microbiology Small Businss: Non HIV Infctious Agnt Dtction/Diagnostic s, Food Safty, Strilization/Disinfc tion and Biormdiation SBID CO Tolrability and fficacy of Zinc thrapy in Mild Cognitiv Impairmnt for tratmnt and prvntion of Alzhimr's disas: a prospctiv, randomizd, doubl blind, paralll, placbo controlld Phas II clinical trial Lazio Rossini Paolo Maria Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration CO Extrmly low frquncy magntic fild (ELF MF) stimulation as a nuroprotctiv tratmnt in acut ischmic strok. Lazio Di Lazzaro Vincnzo Biomdica Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F01 CO Coppr 64 chlorid as a novl diagnostic and thraputic (diaputic) radiotracr in high grad ovarian cancr modls C.R.O. AVIANO casagrand naik Biomdica Oncology 2 Radiation Thraputics and Biology RTB CO Idntification of prdictiv biomarkrs in Multipl Sclrosis using a protomic approach Istituto Suprior di Sanita' Margutti paola Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration CO Novl adaptiv lctromchanical sating dvic, drivn via multipl snsors, to improv th sitting postur of childrn with nurological disass. OSPEDALE BAMBINO GESU' frascarlli flaminia Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT CO Cardiac rgnration: Charactrization, optimization and valuation of forc dvlopd by nginrd tissu obtaind from spontanous or scaffold basd 3D cultur of padiatric human adipos tissu drivd msnchymal stm clls OSPEDALE BAMBINO GESU' Amodo Antonio Biomdica Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS significanc, rol and plasticity of nutrophils in cancr HUMANITAS Jaillon Sbastin Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 2 di 356

3 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt of novl imaging biomarkrs for arly dtction of inhritd and acquird nuro rtinal dgnrations and monitoring of disas progrssion in patints at a cllular lvl basd on high rsolution adaptiv optics rtinal imaging BIETTI Lombardo Marco Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI AUTOLOGOUS OR UMBILICAL CORD DERIVED GROWTH FACTORS AS A NON PHARMACOLOGICAL AND MINI INVASIVE PREVENTIVE APPROACH TO ENHANCE BONE FRACTURE HEALING AND AVOID DELAYED UNIONS AND NONUNIONS THROUGH A RANDOMIZED CONTROLLED CLINICAL STUDY AND PRECLINICAL EVID RIZZOLI Stagni Csar Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Structur and Rgnration SBSR Nw isodgr basd thraputics: toward th dsign of pur intgrin antagonists. SAN RAFFAELE MILANO Ghitti Michla Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function B MSFB Chromogranin A and its drivd pptids as prdictiv markrs of complx vntricular arrhythmias in patints with dilatd cardiomyopathy Calabria Anglon Tommaso Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Mast clls at th chckpoint dcision btwn adnocarcinoma and nurondocrin typ prostat cancr ISTITUTO TUMORI MILANO Jachtti Elna Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Disscting th gntic control and associatd transcriptional profil of common somatic mutations in lung adnocarcinoma ISTITUTO TUMORI MILANO Colombo Francsca Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Intgratd molcular analysis: idntification of prognostic biomarkrs in mtastatic Soft Tissu Sarcoma RIZZOLI Conti Amalia Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Validation of tumor cll vulnrabilitis idntifid by a sirna basd loss of function scrning: a tool for th discovry of nw potntial thraputic targts in thyroid carcinoma ISTITUTO TUMORI MILANO anania maria chiara Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 3 di 356

4 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv CYTOKINE NETWORK UNDERLYING TH17 CELL MEDIATED PATHOGENESIS IN MULTIPLE SCLEROSIS SANTA LUCIA VOLPE ELISABETTA Biomdica Immunology Cllular and Molcular Immunology A CMIA An innovativ nanomotion dtction tool to prform a rapid analysis of th rspons to drugs of poorly diffrntiatd and anaplastic thyroid cancr REGINA ELENA Longo Giovanni Biomdica Oncology 2 Dvlopmntal Thraputics DT MITO AGE: LINKING THE MITOCHONDRIAL GENOME TO HEALTHY AND PATHOLOGICAL AGING Istituto Scinz Nurologich Caporali Lonardo Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD TUMOR RESPONSIVE NANOCARRIERS BASED ON THE HUMAN FERRITIN FOR CANCER THERAPY REGINA ELENA Falvo Elisabtta Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Halth rlatd quality of lif and psychosocial functioning in had and nck cancr patints tratd with curativ intnt: A prospctiv study ISTITUTO TUMORI MILANO Monzani Dario Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Rol playd by bats and othr animals/parasits in th widsprad of MERS CoV IZSME Amoroso Maria Grazia Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Adaptiv prosthtic sockt for transfmoral amputs DON GNOCCHI Monaco Vito Biomdica Emrging Tchnologis and Training in Nuroscincs Nurophysiology, Dvics, Auditory Dvics and Nuroprosthsis Small Businss SBNE A Cll Basd High Throughput Scrning Assay for Transcriptional LARGE Up rgulation in Dystroglycanopathis GASLINI Assrto Stfania Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Crbllar cortical circuits in Autism Spctrum Disordrs: nw prspctivs for tratmnt implmntation. SANTA LUCIA Clausi Silvia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 4 di 356

5 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th mrging rol of ndoplasmic rticulum morphology in lipid mtabolism: invstigation of molcular pathwasy and novl targts for Hrditary Spastic Paraplgia MEDEA Orso Gnny Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Autosomal Dominant and sporadic Frontotmporal Lobar Dgnration: from non coding RNAs to th idntification of prclinical biomarkrs and thraputic targts MAGGIORE Fnoglio Chiara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Smart Adoptiv T cll thrapy for prostat tumors: Endowing T clls with tools to ovrcom PD 1 chckpoint I. O. V. Sommaggio Robrta Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Early tratd patints with phnylktonuria: Cognitiv, mtabolic and nuroimaging corrlats of ditary control in th first gnration of tratd patints to rach adulthood. SANTA LUCIA Palrmo Liana Clinicoassistnzial Biobhavioral and Bhavioral Procsss Cognition, Languag and Prcption Fllowship F12A Undrstanding th dath program inducd by MIF inhibition in CD74 positiv clls ISTITUTO TUMORI MILANO Varinlli Luca Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Nutrophil glatinas associatd lipocalin (NGAL) and matrix mtalloprotinass (MMPs) as biomarkrs of prostat cancr dvlopmnt and progrssion C.R.O. AVIANO Polsl Jrry Biomdica Oncology 2 Cancr Biomarkrs Can biological agnts withdrawn in psoriatic arthritis (PsA) patints aftr a stabl rmission of arthritis is achivd? A clinical, radiological and ultrasonographic study. SAN GALLICANO Gracffa Dario Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Structural and functional charactrization of a novl isoform of vascular ndothlial growth factor A (VEGFA) PASCALE COSTANTINI SUSAN Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function D MSFD Cancr chmoprvntion and thrapy by phytochmical compounds on brast cancr ovrxprssing D16HER2 splic variant in young and old ags I.N.R.C.A. Pirpaoli Elisa Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 5 di 356

6 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rptitiv transcranial magntic stimulation with H coil to rstor cortical inhibitory motor control in focal hand dystonia. SAN RAFFAELE MILANO Houdayr Elis Paul Biomdica Brain Disordrs and Patricia Nuroscinc Nuroplasticity and Nurotransmittrs T Effcts of hart rat rduction by ivabradin, an If currnt inhibitor, vrsus bta adrnrgic blockad by carvdilol, on lft vntricular function and myocardial nrgtics, in patints with systolic hart failur. SAN RAFFAELE MILANO Spolador Robrto Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Signaling ffctors of th Trop 2 pro mtastatic ntwork: novl targts for diagnosis and thrapy Abruzzo Trrotola Marco Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Purification and quantification of cancr microrna biomarkrs using a Lab On a Chip microdvic and th droplt digital PCR tchnology Emilia Romagna Frracin Manula Biomdica Intrdisciplinary Molcular Scincs and Training Small Businss: Dvics and Dtction Systms SBDS Novl Biomarkrs for Improvd Charactrization, Disas Tracking and Outcom Prdiction in Traumatic Brain Injury Associazion Oasi Maria SS Mondllo Stfania Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Innovativ biomatrials to promot priphral nrv rgnration SAN RAFFAELE MILANO Crri Fdrica Biomdica Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Nw micrornas involvmnt in th dvlopmnt of drug rsistanc to targtd trapis in mstastatic mlanoma PASCALE Capon Marialna Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Charactrization of undiagnosd crbllar ataxias. From biochmical biomarkrs to novl thraputic approachs NEUROLESI barca manul Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Epigntic down rgulation of mglu5 mtabotropic glutamat rcptors in Purkinj clls: a novl mchanism of synaps limination in th dvloping crbllum? NEUROMED Notartomaso Srna Biomdica Biology of Dvlopmnt and Aging Dvlopmnt 1 DEV1 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 6 di 356

7 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Short trm ffcts of th implmntation of th NIDCAP modl for vry low birth wight babis Emilia Romagna LUGLI LICIA Clinicoassistnzial Halthcar Dlivry and Mthodologis Nursing Scinc: Childrn and Familis NSCF Implmntation of first lin chmothrapy of lung and plural cancrs by typ I IFN: ffcts on chmorsistanc and tumor immunognicity Istituto Suprior di Sanita' Bracci Laura Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Antign loadd solid lipid nanoparticls for immunothrapy in glioblastoma Lombardia Panciani Pir Paolo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Uunravling gntic divrsity of nosocomial Candida parapsilosis isolats using th rstriction sit associatd DNA squncing (RAD sq) tchniqu as a novl tool for high rsolution pidmiology NEUROLESI Scordino Fabio Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Idntification, clinical impact, and charactrization of nw gntic dtrminants of nonalcoholic fatty livr disas MAGGIORE Valnti Luca Vittorio Biomdica Gns, Gnoms and Carlo Gntics Gntics of Halth and Disas GHD Study on th rol of mchanical load mdiatd ffcts in th pathognsis of ostosarcoma. OSPEDALE BAMBINO GESU' Pruzzi Barbara Biomdica Oncology 1 Basic Molcular Oncognsis MONC Cystic Echinococcosis biomarkr idntification for diagnosis, cyst viability dfinition and thrapy outcom prdiction Istituto Suprior di Sanita' fratini fdrica Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Enginrd rgulatory T cll Adoptiv Cll Thrapy as a novl tool for th tratmnt of Cardiovascular disass HUMANITAS KALLIKOURDI MARINOS Biomdica Cardiovascular and S Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Tmozolomid basd thrapy in Ewing sarcoma patints: prognostic and prdictiv rol of MGMT promotr mthylation RIZZOLI Palmrini Emanula Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 7 di 356

8 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nw molcular mchanisms and biomarkrs associatd with anthracyclins and trastuzumab inducd cardiotoxitity: rol of th nuclolar protin Nuclophosmin and its associatd mirnas ISTITUTO DERMOPATICO DELL'IMMACOLATA Avitabil Danil Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Inhibition of mir 125b in th SOD1 G93A mous as innovativ approach to rstrain Amyotrophic Latral Sclrosis SANTA LUCIA Parisi Chiara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nw mtor inhibitors dvlopmnt and study of thir ffcts on th cntral nrvous systm(mtorneu) Calabria Russo Emilio Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Rol of z Crystallin in acidic tumor micronvironmnt: molcular mchanisms and thraputics implications Toscana Lulli Matto Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP p53 control of th autophagic procss in a modl of Alzhimr's Disas SANTA LUCIA Mrlo Paola Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN "Antivir aging": xploiting plasmacytoid Dndritic Cll rspons as a bridg btwn innat and adaptiv immunity to improv influnza vaccin fficacy in th ldrly Istituto Suprior di Sanita' Svra Martina Biomdica Immunology Innat Immunity And Inflammation III ROLE OF THE DIET IN THE MAINTENANCE OF REMISSION IN PEDIATRIC INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE, RANDOMIZED, CONTROLLED, PARALLEL GROUP STUDY. Lazio Aloi Marina Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG NK clls for th Prvntion of HCV rcurrnc in livr transplantation Sicilia Badami Estr Biomdica Immunology Innat Immunity And Inflammation III Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 8 di 356

9 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Enginrd bio organ for bta cll rplacmnt in typ 1 diabts SAN RAFFAELE MILANO Valria Danila Sordi Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Diabts, Mtabolism, Nutrition and Obsity Small Businss SEP (EMNR E10 B) Dsign of novl polythr thr kton (PEEK) implants coatd with nanostructurd biomimtic apatit for ostoporotic patints RIZZOLI Bianchi Michl Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Non classical MHC I human lukocyt antign G (HLA G) in hpatocllular carcinoma BURLO GAROFALO Sgat Ludovica Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII Study on th rol of gonadal hormons on ACTHscrting pituitary adnomas AUXOLOGICO Cassarino Maria Francsca Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Proof of Concpt prospctiv randomizd controlld trial on arly tratmnt with ithr high or standard dos caffin in vry prtrm infants to valuat th ffcts on brain dvlopmnt and rspiratory morbidity. GASLINI Bruschttini Matto Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD ACTonFood. Fasibility, Effctivnss and Costffctivnss of a stppd car, wb basd Accptanc and Commitmnt thrapy for food addiction in obs patints with pr diabts or Typ II diabts sking tratmnt for wight loss and rlatd co morbidi AUXOLOGICO Manzoni Gian Mauro Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Establishmnt of a nw prclinical modl of lat stag, prostatctomizd prostat cancr. Assssing th impact of prostat ablation on th sprad of nodal and xtranodal prostat cancr mtastass. SAN RAFFAELE MILANO Buono Robrta Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Study of th kynurnin pathway in schizophrnia: sarching for novl priphral biomarkrs and thraputic stratgis. NEUROMED Fazio Francsco Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 9 di 356

10 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rscu stratgis of dopamin signalling dysfunction in inhritd dystonias. SANTA LUCIA Tasson Annalisa Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Altrations of Antioxidant Systms and Nitric Oxid Biosynthtic Pathway in th Progrssion of Calcific Aortic Valv Disas MONZINO Poggio Paolo Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR At th cross road btwn mucosal inflammation and carcinognsis: nw thraputic approachs to modulat inflammasom dpndnt lung cancr progrssion. DE BELLIS Sorrntino Rosalinda Biomdica Immunology Innat Immunity And Inflammation III Gn thrapy approachs to corrct cornal disordrs in EEC syndrom causd by mutations in p63 gn. Vnto Barbaro Vanssa Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Novl Immunothraputic stratgy combining Unconvntional T clls with Dndritic Cll basd vaccination in Rnal Cll Carcinoma. Puglia Gigant Marghrita Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Molcular charactrization of tumor associatd macrophags in human colorctal cancr. I.E.O. Ghisltti Srna Maria Biomdica Gns, Gnoms and Luisa Gntics Molcular Gntics MGA Prospctiv valuation of prvalnc and risk factros of d novo mtabolic syndrom aftr livr transplantation Vnto Grmani Giacomo Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Evaluation of th scondary pilptognsis hypothsis and dfinition of possibl biomarkrs CARLO BESTA Noè Francsco Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE UNRAVELLING THE CAUSE EFFECT RELATIONSHIP BETWEEN PERFORMANCE ENHANCING DRUG ABUSE AND CARDIOVASCULAR IMPAIRMENT SDN Imprlini Esthr Biomdica Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 10 di 356

11 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Impact of anti HCV prophylaxis with nw dirct activ antivirals to prvnt rcurrnc of infction in candidats to livr transplant. SPALLANZANI Lanini Simon Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS A NEW CHEMICAL BIOLOGY APPROACH FOR PRION DISEASES Istituto Suprior di Sanita' Massignan Tania Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Rsarch on molcular pathways of rnal damag and thir modulation in xprimntal and clinical modls of congnital uropathyby using nanocarrirs Puglia Pastor Valntina Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO MiR 34a: novl playr and potntial thraputic targt in vascular calcification MONZINO Badi Ilana Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Unravlling th rol of th srin thronin kinas Ulk1 in axon growth and rgnration SANTA LUCIA Nazio Francsca Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurodiffrntiation, Plasticity, and Rgnration NDPR Human urinary protom in normality and in disass: nw tchnology approachs and stratgis GASLINI Santucci Laura Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Disscting and targting HS1 mdiatd cytoskltal activity in Chronic Lymphocytic Lukmia clls and covolving micronviromnt SAN RAFFAELE MILANO Scilzo Cristina Biomdica Oncology 1 Basic Tumor Cll Biology TCB Rol of ghrlin gn drivd pptids and Exndin 4 on immun rspons and inflammation in lymphocyts from typ 1 diabtic patints Pimont Trovato Ltizia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Long non coding RNA as srum markr to prdict rspons to sorafnib in Hpatocllular carcinoma Emilia Romagna Baglioni Michl Biomdica Oncology 2 Cancr Biomarkrs Pharmacological bolstring of lipid rafts catalytic function in targting lymphoma Istituto Suprior di Sanita' ciarlo laura Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 11 di 356

12 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Patints' inducd pluripotnt stm clls for thrapy prsonalization: th paradigm of thiopurin inducd pancratitis in Crohn's disas BURLO GAROFALO Stocco Gabril Biomdica Digstiv, Kidny and Urological Systms Xnobiotic and Nutrint Disposition and Action XNDA Cost and ffctivnss valuations of actions that can b includd in th National Radon Action Plan and production of othr rlvant data usful for its dvlopmnt. Istituto Suprior di Sanita' Antignani Sara Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Quantification and comparison of ndoscopic and microscopic approachs to th skull bas: application of a novl, nuronavigation basd, rsarch mthod for th dvlopmnt of vidnc basd, prclinical studis in skull bas surgry Lombardia Doglitto Francsco Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Th RNA binding protin FMRP and hnrnp C: nw targt for rgulating amyloid prcursor protin lvls in alzhimr disas SANTA LUCIA borrca antonlla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Traumatic strss, micrornas and synaptic plasticity: implications for post traumatic strss disordr SANTA LUCIA Rinaldi Arianna Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA INVESTIGATION OF MOLECULAR BASIS OF AGGRESSIVENESS IN SYSTEMIC MASTOCYTOSIS Toscana Piri Lisa Biomdica Oncology 2 Cancr Biomarkrs Prnatal xposur to polybrominatd diphnyl thrs: molcular mchanisms of dvlopmntal nurotoxicity and nurofunctional implications in a mous modl MARIO NEGRI D Paola Massimiliano Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Oxidativ strss and amyotrophic latral sclrosis (ALS): th rol of MDM4 SANTA LUCIA Mancini Francsca Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 12 di 356

13 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv MCL 1 as progonostic/thranostic markr in padiatric patints affctd by Acut Lymphoblastic Lukamia (ALL) BURLO GAROFALO Franca Raffalla Clinicoassistnzial Oncology 2 Cancr Biomarkrs An intgratd molcular and functional approach to undrstand th phnotypic variability in ciliopathis CASA SOLLIEVO SOFFERENZA Romani Marta Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurognsis and Cll Fat NCF BIOMARKER DRIVEN RATIONAL COMBINATION THERAPIES TO IMPROVE RESPONSE TO ANTI EGFR TREATMENT IN COLORECTAL CANCER: A PRECLINICAL STUDY, TAILORED AROUND HYPOTHESIS GENERATING PREDICTORS, IN PATIENT DERIVED XENOGRAFTS Istituto Oncologico Candiolo BERTOTTI Andra Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Extra corporal mmbran oxygnation vs. convntional CardioPulmonary Rsuscitation for rfractory out of hospital cardiac arrst: a randomizd controlld trial E CPR study Lombardia Mauri Tommaso Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Phas II Trial of Tmozolomid in Patints affctd by Rlapsd Snsitiv or Rfractory Small Cll Lung Cancr with MGMT mthylation Emilia Romagna Casanova Claudia Clinicoassistnzial Oncology 2 Oncology CONC mtor inhibition mdiatd nuroprotction in mitochondrial disordrs: molcular mchanisms and thraputic ffcts. Toscana Flici Robrta Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN An innovativ machin prfusion (Bologna Prfusion Machin) for abdominal organ prsrvation bfor transplantation. Optimization of prfusion, tmpratur and oxygnation rlatd variabls Emilia Romagna Ravaioli Matto Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Dtction of gn polymorphisms associatd to cardiovascular risk in saliva of Priodontitis patints: biochip dsign for Routin Diagnostic Tsting Sicilia Isola Gatano Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 13 di 356

14 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv HIV 1 Tat intraction with host microrna rgulatory ntwork: implications for immun and nuronal dysfunction Calabria Fium Giuspp Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Exploring th gntic landscap of Chronic Lymphocytic Lukmia by focusing on strotypd substs to dcras th htrognity of th disas: a novl approach to unvil potntial markrs of prognosis and targts for thrapy. SAN RAFFAELE MILANO Agathanglidis Andras Biomdica Oncology 1 Basic Cancr Gntics CG PD L1+ hmatopoitic stm clls: a novl stm cll basd approach for typ 1 diabts Idntify th pigntic altrations undrlying monocyt dysrgulation in Systmic Sclrosis: th path toward novl thraputic opportunitis SAN RAFFAELE MILANO D'addio Francsca Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Vnto Rossato Marzia Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Population basd patint rgistry of chronic cholstatic, autoimmun livr disas in Lombardia and Dnmark and dvlopmnt of a risk stratifid halthcar pathway for th disas HUMANITAS Carbon Marco Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS CDKL5 associatd disordrs and brain Rho GTPass: in sarch of innovativ thraputic targts Istituto Suprior di Sanita' D Filippis Bianca Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Disscting mlanoma htrognity by intgrativ gnomic analysis for tailord anti cancr thrapy ISTITUTO TUMORI MILANO Dugo Matto Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Advancd structural and functional Magntic Rsonanc at 1,5T, 3T and UHF (7T) in distal Nuromuscular Disordrs STELLA MARIS Astra Guja Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 14 di 356

15 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv tdcs ovr th lft frontal ara spds up spch rcovry in svr post strok aphasia SANTA LUCIA FIORI VALENTINA Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Quantification of crbral oxygn mtabolism for nurological disass using MRI. SANTA LUCIA Gili Tommaso Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Th rol of th protin tyrosin phosphatas PTPN22 in th pathognsis of autoimmunity in common variabl immunodficincy SAN MATTEO BORGHESI ALESSANDRO Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Modulation of ndognous circulating ndothlial prognitor clls protcts from subarachnoid hamorrhag inducd vasospasm and dlayd ischmic injury IRCCS AOU San Martino IST (Gnova) Bacigaluppi Susanna Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Analysis of biomolcular profil in human mningiomas. Idntification of potntial targts for novl thraputic stratgis in rcurring or not rsctabl tumours. Sicilia Barrsi Valria Biomdica Oncology 1 Basic Molcular Oncognsis MONC Skin tumor modls to study mchanisms of cancr rgrssion Sicilia Zito Giovanni Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Contributing rol of viral infction in idiopathic pulmonary fibrosis (IPF) in comparison to non IPF intrstitial lung disass: clinical and xprimntal study of th principal pathogntic pathways involvd in fibrognsis. Vnto LUNARDI FRANCESCA Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Risk Of Hmorrhag in Cardiombolic Strok Study (ROHCSS). A prospctiv study on nuroradiological and laboratoristic prdictors of anticoagulant associatd crbral hmorrhag in cardiombolic ischmic strok and transint ischmic attack. MAGGIORE Lanfranconi Silvia Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 15 di 356

16 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Molcular profil of xcptional rspondr patints with advancd non small cll lung cancr (NSCLC) or malignant plural msothlioma (MPM) Emilia Romagna Tiso Marcllo Biomdica Oncology 2 Cancr Biomarkrs Quantitativ lung ultrasonography to assss xtravascular lung watr and structural lung parnchymal drangmnts in acut rspiratory failur. Liguria Brusasco Claudia Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Longitudinal multi paramtric clinical, CSF and MRI study aimd at prdicting disability progrssion in Multipl Sclrosis Vnto Calabrs Massimiliano Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT valu of prcutanous abdominal biopsy undr PET CT/ultrasound fusion imaging guidanc Liguria Paparo Francsco Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Computrizd masurmnt of Sarcopnia in patints with cirrhosis and hpatocllular carcinoma and application of a customizd multidisciplinary protocol of nutritional support and motor rhabilitation in ordr to improv thir outcom. Lazio BEGINI PAOLA Clinicoassistnzial Oncology 2 Oncology CONC Immun profiling at tumor sit to prdict rsponsivnss to immunothrapy in non small cll lung cancr patints. ISTITUTO TUMORI MILANO Tassi Elna Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Protins forming corona and intraction with hybrid nanoparticls: potntial innovativ stratgy providing a nw thraputic approach for nanomdicin. SDN Clia Christian Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Th rol of visuospatial abilitis in th arly diffrntiation btwn Dmntia with Lwy Bodis and Alzhimr's disas: nuropsychological and nuroimaging vidnc S.CAMILLO Mitolo Micala Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Protomics in thyroid pathology: MALDI imaging as a nw diagnostic tool Lombardia pagni fabio Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 16 di 356

17 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Circulating molcular markrs for prsonalizd thrapy in gliomas MONDINO Di Stfano Anna Luisa Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Idntification of novl thraputics for Spinal Muscular Atrophy with Rspiratory Distrss typ 1 (SMARD1) using an ipscmodl of th disas MAGGIORE Simon Chiara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dmntia vs cognitiv prsrvation: diffrncs and similaritis in th gntic background I.N.R.C.A. Dato Srna Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Promoting crbral plasticity for th walking rcovry in strok by transcranial crbllar dirct currnt stimulation SANTA LUCIA Fusco Augusto Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Rol of micrornas and bon morphogntic protins in calcific aortic valv disas Puglia Galon Antonlla Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Patint Spcific Biomchanical Modling for Customizing th Surgry and Protcting th Cartilag of Patllo Fmoral Joint RIZZOLI Marchggiani Muccioli Giulio Maria Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO IMPACT OF CONTRACTILE RESERVE AND CORONARY FLOW RESERVE ON EXERCISE CAPACITY AND PROGNOSIS IN PATIENTS WITH NON ISCHEMIC DILATED CARDIOMYOPATHY. MECHANISTIC INSIGHTS FROM CARDIAC ADRENERGIC IMAGING. SDN Gargiulo Paola Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Crbllum optimizs control of snsory motor coupling in fixational saccads Toscana Fdrighi Pamla Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 17 di 356

18 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Diaphragmatic dysfunction in critically patints undrgoing mchanical vntilation. Emilia Romagna Spadaro Savino Clinicoassistnzial Cardiovascular and Rspiratory Scincs Rspiratory Intgrativ Biology and Rsarch RIBT Intrcllular propagation of polyq xpandd protins in Huntington disas:structural dtrminants, cllular mchanisms, and rol in disas progrssion MARIO NEGRI Fioriti Luana Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Childhood obsity, Insulin Rsistanc (IR) and ndothlial dysfunction: potntial rol of plasma mirnas and ndothlial Endoplasmic Rticulum (ER) strss. Abruzzo Marcovcchio Maria Lordana Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Ar altrations of plasma phospholipids prdictiv biomarkrs for Alzhimr Disas? A mtabolomicsbasd study of th ffct of aging and nurodgnration on mtabolism. CARLO BESTA Loni Valrio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Cholinrgic dysfunction as a common mchanism for mild cognitiv impairmnt (MCI) in cancr survivors and patints with nurodgnrativ disass: multidisciplinary approach and intrvntional stratgis. IRCCS AOU San Martino IST (Gnova) Morblli Silvia Danila Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Th rol of authopagy as a protctiv mchanism in cardiovascular disass: nw insights into oxidativ strss modulation and cardiovascular rgnration NEUROMED Sciarrtta Sbastiano Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Prsonalizd immunothraputic stratgis for trastuzumab rsistant HER2 positiv brast cancr Pimont occhipinti srgio Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Functional inhibition of HSP105 as a nw thraputic stratgy for human aggrssiv B cll non Hodgkin lymphomas ISTITUTO TUMORI MILANO Zappasodi Robrta Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 18 di 356

19 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of Lamin A/C Polycomb crosstalk in Emry Drifuss Muscular Dystrophy (EDMD) SANTA LUCIA Lanzuolo Chiara Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Radiodynamic thrapy and proton pump inhibitors for th tratmnt of pain in patints with bon mtastass RIZZOLI Avnt Sofia Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Disscting th pigntic rol of DNA rptitiv lmnts in muscl diffrntiation; implications for muscular dystrophy MAGGIORE Bodga Batric Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Idntification and rscu of synaptic dysfunction in PINK1 autosomal rcssiv parkinsonism. SANTA LUCIA Mado Grazilla Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Whn my uppr limb mts my lowr pain: modulation of nuropathic pain aftr spinal cord injury through virtual mbodimnt and lowr limbs control. SANTA LUCIA Tidoni Emmanul Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Gndr ffcts on cognitiv rhabilitation in multipl sclrosis patints Sicilia Ralmuto Sabrina Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Pharmacological stratgis for infliximab rspons prdiction and thraputic monitoring in pdiatric inflammatory bowl disass BURLO GAROFALO Taddio Andra Biomdica Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Dynamics of Lamin A intraction with multiprotin complxs in Emry Drifuss Muscular Dystrophy (EDMD): idntification of molcular and thraputical targts for both diagnostic and novl thrapis in nuclar lamina associatd pathologis. RIZZOLI Piazzi Manula Biomdica Cll Biology Nuclar and Cytoplasmic Structur/Function and Dynamics NCSD Enhancrs as nw targts of intrvntion in glioblastoma rlaps: from computational infrnc to functional validation I.E.O. Cristofanon Silvia Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 19 di 356

20 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of molcular markrs of consistncy, potncy and fficacy of IFN DC basd drugs for lymphoma immunothrapy Istituto Suprior di Sanita' Castillo Luciano Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Idntification of th chromatin profil prdicting th rsponsivnss of dystrophic patints to pigntic thrapy SANTA LUCIA Mozztta Chiara Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP and biological prdictors of dprssion in chronic hpatitis C subjcts tratd with pgifn alpha Vnto Tosato Sarah Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Nurondocrinology, Nuroimmunology and Bhavior NNB Idntification of colorctal cancr (CRC) drivd lipid antigns to nhanc anti tumour inkt cytotoxicity in antign spcific vaccination protocols I.E.O. Facciotti Fdrica Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Prvntion of cancr thrapy rlatd hart failur through phosphoinositid 3 kinas gamma inhibition Pimont Morllo Fulvio Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF A nw cllular modl of Alzhimr's disas rproducing in vitro phatophysiological faturs of dgnrating clls: a translational study to invstigat th rol of lctromagntic stimulation and circulating molcular biomarkrs SAN MATTEO Vnturini Ltizia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Th rol of urokinas (upa) and its rcptor (upar) in IBD pathognsis: implication for novl thraputic approachs. HUMANITAS Gnua Marco Biomdica Immunology Innat Immunity And Inflammation III Unconvntional rol of th inhibitor of apoptosis (IAP) protins in promoting mtastatization ISTITUTO TUMORI MILANO Lcis Danil Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Efficacy and safty of post oprativ doubl anti platlt thrapy in patints rvascularizd with coronary artry bypass grafting Emilia Romagna Bnassi Filippo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 20 di 356

21 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv INTERACTION BETWEEN MESENCHYMAL STEM CELL/STROMA AND HEMATOPOIETIC COMPARTMENT AFTER BONE MARROW TRANSPLANTATION: EFFECTS ON MAJOR OUTCOME OF TRANSPLANT. Emilia Romagna PREZIOSO LUCIA Biomdica Vascular and Hmatology Hmatopoisis HP Estimating th risk for cardiac toxicity in patints undrgoing anticancr thrapis: a nw dynamic risk algorithm intgrating lvls of cardiovascular srum biomarkrs. Liguria Puntoni Matto Clinicoassistnzial Oncology 2 Oncology CONC A novl us of CXCR4 inhibitors to prvnt th dissmination of mtastasis initiating clls inducd by chmothrapy ISTITUTO TUMORI MILANO Brtolini Giulia Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Turning th blind brain to s. Rstoration of visual functions in patints with cortical blindnss using dirct brain stimulation and biologically salint stimuli. MAUGERI Tamitto Marco Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cntral Visual Procssing CVP Targting th oxytocinrgic systm in th tratmnt of psychiatric disordrs programmd by arly lif strss NEUROLESI Marrocco Jordan Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Nurondocrinology, Nuroimmunology and Bhavior NNB Closd loop crbro crbllar connctivity: implications for larg scal ntwork dysfunction in nurodgnrativ disass MONDINO Palsi Fulvia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI PHARMACOLOGICAL CHARACTERIZATION OF OXYTOCIN, DOPAMINE AND OPIOID RECEPTOR HETERODIMERS FOR THE DEVELOPMENT OF NEW THERAPEUTICAL MOLECULES FOR AUTISM AND SCHIZOPHRENIA HUMANITAS Busnlli Marta Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Molcular Nuropharmacology and Signaling MNPS Stpping toward th pathognic rol of Ambra1 complx in nuro muscular disass: from animal modls to thraputic prspctivs SANTA LUCIA Grumati Paolo Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 21 di 356

22 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Trans gnrational transmission of vulnrability signaturs for mntal disordrs: th rol of arly lif strss and inflammation. FATEBENEFRATELLI Cattano Annamaria Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Innovativ tchnologis for minimal rsidual disas (MRD) in matur lymphoid tumors Pimont Frrro Simon Biomdica Oncology 2 Cancr Biomarkrs Rol of biological markrs for crbral blding risk stratification in patints with atrial fibrillation on oral anticoagulants for primary or scondary prvntion of ischmic strok Toscana Poggsi Anna Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Iron dpltion approach for th rsolution of th HCVinducd statohpatitis: dvlopmnt ofnw thraputic stratgy SPALLANZANI Mancon Carmin Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Modulation of oxidativ strss by suproxid dismutas 3 (SOD3) in colorctal cancr (CRC) dvlopmnt and rspons to thrapy SDN castllon maria domnica Biomdica Oncology 1 Basic Molcular Oncognsis MONC Th micronvironmnt can influnc th rol of adipos stm clls in brast cancr rcurrnc. Sicilia di stfano anna barbara Biomdica Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Dciphring th rol of SETD5 in intllctual disabilitis and stting a nw gn on thraputic stratgy. SAN RAFFAELE MILANO Sssa Alssandro Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Priodontal Disas and Arthritis: Dvlopmnt of a Multidisciplinary Unit Toscana Graziani Filippo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD ROLE OF NF KB DYNAMICS IN PROGERIA AND AGE RELATED INFLAMMATION SAN RAFFAELE MILANO Zambrano Samul Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 22 di 356

23 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Innovativ approachs for multipl myloma micronvironmnt charactrization and B cll drivd xosoms trapping Calabria Iaccino Enrico Biomdica Oncology 1 Basic Tumor Micronvironmnt TME An innovativ rol for srum xtracllular mmbran vsicls: prognosis and progrssion of hpatocllular carcinoma (HCC). Emilia Romagna Turola Elna Biomdica Oncology 2 Cancr Biomarkrs Th risk bnfit profil of pharmacological tratmnts in scondary prvntion for patints with ischmic strok: a systmatic rviw CARLO BESTA Tramacr Irn Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD Innovativ multisnsory stimulation systm for ntraining locomotor circuitry and nhancing gait rhabilitation SANTA LUCIA Sylos Labini Francsca Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Snsorimotor Intgration SMI Exploring th rol of AMPK pathway in th altration of hippocampal plasticity in a transgnic mous modl of Alzhimr's Disas SANTA LUCIA Cavallucci Virv Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Analysis of th lipid rafts protom (raftom) in prilsional mlanocyts as wll as in primary and mtastatic mlanoma clls from th sam patint for th idntification of nw thraputic targts and markrs of tumor progrssion. Istituto Suprior di Sanita' Marconi Matto Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM In vivo chmical scrning for modulators of CREB inducd myloid lukmia. Vnto PIGAZZI MARTINA Biomdica Oncology 1 Basic Tumor Cll Biology TCB Ipsilatral invasiv transformation or in situ rlaps of ductal brast carcinoma in situ: rol of biomarkrs (HJURP,TGM2, HIF 1 alpha, Androgn Rcptor and mirnas 9, 210, 200) for prognosis and for prdiction of rspons to radiothrapy Istituto Scintifico Romagnolo Bravaccini Sara Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 23 di 356

24 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Comprhnsiv tracking of hmatopoitic stm/prognitor clls dynamics and activity in vivo in humans by insrtional barcoding SAN RAFFAELE MILANO Biasco Luca Biomdica Gns, Gnoms and Gntics Gn Thrapy and Inborn Errors GTIE Spcial Emphasis Panl Th rol of cllular snscnc in th progrssion from chronic livr inflammation to cancr HUMANITAS Faggioli Francsca Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Autophagy modulation for promoting cll survival and rcovry aftr Spinal Cord Injury. SANTA LUCIA Bisicchia Elisa Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Idntification of clinically rlvant mutation signaturs in cutanous mlanoma as potntial biomarkrs of diffrnt molcular subtyps Abruzzo Pllgrini Cristina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Mchanisms of immuno chmorsistanc in NOTCH1 mutatd chronic lymphocytic lukmia: implications for spcific targt thrapis C.R.O. AVIANO Dal Bo Michl Biomdica Oncology 1 Basic Tumor Cll Biology TCB Rmot brain damag: targting th pignom as an innovativ approach to countract nurodgnration. SANTA LUCIA Latini Laura Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Fasibility and activity of ditary intrvntion in had and nck cancr carcinoma survivors: a Phas II multicntr prospctiv randomizd trial. ISTITUTO TUMORI MILANO Bossi Paolo Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP Gntic and pigntic mchanisms in disordrd gambling: an opportunity for th dvlopmnt of nw thraputic stratgis MAGGIORE Dll'osso Brnardo Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Disscting th rol of unxplord mir 205 host gn as a basal cll spcific long non coding RNA in prostat cancr dvlopmnt ISTITUTO TUMORI MILANO Gandllini Paolo Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Fibroblasts as in vitro modl for th idntification of Tratmnt Rsistant Dprssion (TRD) biomarkrs FATEBENEFRATELLI Milansi Elna Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 24 di 356

25 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rgnration of th ocular surfac by targting th Akt2 mtorc1 pathway Vnto Elbadawy Hossin Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST MicroRNAs to targt cancr stm clls in lung cancr ISTITUTO TUMORI MILANO Bori Mattia Biomdica Oncology 2 Dvlopmntal Thraputics DT Dvlopmnt and pr tsting of a novl nzym rplacmnt thrapy for Krabbdisas: aptamrmdiatd GALC dlivry into th cntral nrvous systm. STELLA MARIS Ccchini Marco Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN NEW DRUGS COMBINATION FOR MALIGNANT PLEURAL MESOTHELIOMA TREATMENT I. O. V. Urso Lordana Biomdica Oncology 1 Basic Tumor Cll Biology TCB Nutrophil traps in lukmia: from triggrs of disas progrssion to vhicl for nw vaccins ISTITUTO TUMORI MILANO Sangaltti Sabina Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Idntification of prsymptomatic markrs in Parkinson's disas SAN RAFFAELE MILANO Piccoli Giovanni Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Involvmnt of glia dysfunction in pilpsy: focal downrgulation of Kir4.1 channl in rats with cortical dysplasia CARLO BESTA Moroni Ramona Frida Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE PROTEOMIC PROFILE AND INFLAMMATORY CYTOKINE TO DISCRIMINATE BENIGNE VS BREAST CANCER PATIENTS IN PRESENCE OF MAMMOGRAPHIC SUSPECT ONCOLOGICO DI BARI Garrisi Vito Michl Biomdica Oncology 2 Cancr Biomarkrs Ag rlatd haring loss: from gn idntification to a bttr diagnosis and prvntion BURLO GAROFALO Girotto Giorgia Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Rol of non coding RNAs in rsistanc to targtd thrapis in cutanous mlanoma C.R.O. AVIANO Fratta Elisabtta Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 25 di 356

26 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Unravlling th pathogntic pathways in an xprimntal modl of Diabtic Encphalopathy by a omics basd platform: potntial for novl diagnostic and thraputic intrvntions Puglia Gnoni Antonio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO High snsitiv immunosnsors for th dtction of foodborn pathogns IZSME DELLA BARTOLOMEO Biomdica Infctious Disass and VENTURA Microbiology Infctious Disass and Microbiology Fllowship F Nuropsychological functioning and brain ntwork organization at th onst of focal childhood pilpsy: implications for arly diagnosis and cognitiv tratmnt Istituto Scinz Nurologich filippini mlissa Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Nurobiology of Larning and Mmory LAM Invstigation of molcular mchanisms and possibl thraputic stratgis in modls of ftalalcohol spctrum disordr and alcohol dpndnc. Toscana Grac Elisabtta Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Slctiv targting of Glioblastoma clls by drugfunctionalizd Antibodis and Avidin Nuclic Acid Nano ASsmblis (ANANAS) and in vivo monitoring by Confocal Lasr Endomicroscopy (CLE). Vnto Prsano Luca Biomdica Oncology 2 Dvlopmntal Thraputics DT Adnosin A2A rcptors as potntial thraputic targts in Fragil X syndrom Istituto Suprior di Sanita' Frrant Antonlla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Biochmical and molcular basis of multimodal MRI and PET mtabolic imaging in pdiatric gliomas: from biology to clinical implications. GASLINI Masclli Samantha Biomdica Oncology 2 Cancr Biomarkrs Mass Cytomtry Analysis: a nw approach to invstigat ky mchanisms in prdicting rspons to chmothrapy in ovarian cancr patints Istituto Suprior di Sanita' Luca Pasquini Biomdica Oncology 2 Cancr Biomarkrs In vitro and in vivo analysis of ATP ffct in Acut Myloid Lukmia clls: dvlopmnt of novl thraputic stratgis Emilia Romagna Salvstrini Valntina Biomdica Oncology 2 Dvlopmntal Thraputics DT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 26 di 356

27 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Pathophysiological and prognostic aspcts of Mdication Ovrus Hadach: insight from function Magntic Rsonanc Imaging. Umbria Caproni Stfano Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Targting cutanous anti apoptotic PI3K/AKT signalling as a nw thraputic approach for trating skin inflammation ISTITUTO DERMOPATICO DELL'IMMACOLATA Madonna Stfania Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Adjuvant proprtis of plant xtract componnts in anticancr HPV vaccins producd in grn biofactoris. REGINA ELENA Paolini Francsca Biomdica Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] EN: study of th oncognic rol of NPM/ALK in Anaplastic Larg Cll Lymphoma (ALCL)IT: Analisi traslazional dl ruolo oncognico di NPM/ALK in Linfoma Anaplastico a Grandi Cllul (ALCL) Lombardia MAGISTRONI VERA Biomdica Oncology 1 Basic Cancr Gntics CG EN: Idntification of somatic mutations and gn fusions by whol transcriptom squncing in acut myloid lukmiait: Idntificazion di mutazioni somatich fusioni gnich in pazinti afftti da lucmia miloid acuta tramit squnziamnto dll in Lombardia Rdalli Sara Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Tlomras activatd pro drugs activatd as a novl pharmacological approach to hpatocllular carcinoma tratmnt. Toscana Tarocchi Mirko Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Hypothalamic control of priphral immun tolranc: novl modl for th study of multipl sclrosis. SANTA LUCIA Procaccini Claudio Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Crbro crbllar connctivity in dynamic rsting stat ntworks: implications for larg scal ntwork dysfunction in nurodgnrativ disass. MONDINO Castllazzi Gloria Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 27 di 356

28 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rlvanc of non coding RNA in th biological and clinical htrognity of Multipl Myloma: a highthroughput squncing approach. MAGGIORE Liontti Marta Biomdica Oncology 1 Basic Molcular Oncognsis MONC Mchanisms of HIV 1 rstriction and dissmination mdiatd by mucosal myloid clls SAN RAFFAELE MILANO Cavarlli Mariangla Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Evaluation of a rstrictd mirna signatur, with particular focus on lt 7c, as markr of prognosis, tratmnt outcom and thraputic tool in acut myloid lukmia REGINA ELENA Plosi Andra Biomdica Oncology 1 Basic Molcular Oncognsis MONC Phnotypic htrognity of Alzhimr disas: towards th idntification of molcular dtrminants undrlying distinct clinico pathological subgroups CARLO BESTA Catania Marclla Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration ULTRASENSITIVE DIAGNOSTIC TEST FOR DEGENERATIVE DEMENTIAS BASED ON AMPLIFICATION OF PERIPHERAL DISEASE SPECIFIC BIOMARKERS FROM THE OLFACTORY MUCOSA CARLO BESTA Moda Fabio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Mlatonin & Rsvratrol: a nw prspctiv to corrct th autophagy dfct in Duchnn Muscular Dystrophy TSE IN GOATS: STRAINS CHARACTERIZATION AND RISK FOR HUMANS Th structural and functional rol of EMILIN1 in lymphatic vasculatur: prospcts for lymphdma tratmnt with an xtracllular matrix protin. RIZZOLI Pllgrini Camilla Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS IZSPLV Iulini Barbara Biomdica Vtrinary Animal Halth ANHE C.R.O. AVIANO Pivtta Eliana Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 28 di 356

29 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Botulinum toxin and chronic migrain: long tm clinical fficacy and pigntic aspcts Umbria Corblli Ilnia Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Pharmacology and Diagnostics for Nuropsychiatric Disordrs and Nural Systms Small Businss SBPD Intratumoral tratmnt of unrscatabl primary and mtastatic solid cancr with Yttrium 90 microsphrs using an orthotopic mous modl of pancratic adnocarcinoma PASCALE Barbiri Antonio Biomdica Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Idntification of nw NCX activators as nuroprotctiv agnts in crbral ischmia SDN Cuomo Ornlla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Chmosnsitizing action of voacamin on in vitro and in vivo multidrug rsistant tumor modls Istituto Suprior di Sanita' Condllo Maria Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Idntification and function of novl biomarkrs in bon mtastatic tumors RIZZOLI CARINA VALERIA Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Dynamics and mtabolic pathways lading to immunrgulation in Multipl Sclrosis. SANTA LUCIA Sambucci Manolo Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Exploiting xnograft tumor modls to prdict rspons to molcular targtd thrapis in advancd pithlial ovarian cancr Lombardia Fruscio Robrt Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Purinrgic P2X7 rcptor modulation as a novl thraputic stratgy against Amyotrophic Latral Sclrosis SANTA LUCIA Apolloni Savina Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 29 di 356

30 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Causativ rol of pigntic dysrgulation in inducing rsistanc to immunomodulatory drugs (IMiDs): implications for th thraputic targting of IMiDsrsistant Diffus Larg B cll Lymphoma (DLBCL) with DNA mthyltransfras inhibitors (DNMTIs) in comb HUMANITAS LOCATELLI SILVIA LAURA Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Hmatologic manifstations in mitochondrial disordrs: charactrization, tiology, and pathognsis. OSPEDALE BAMBINO GESU' EMMANUELE VALENTINA Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD VIOLENCE AGAINST WOMEN AND EMERGENCY HEALTH SERVICES: a controlld trial to compar diffrnt training programms for halth workrs FATEBENEFRATELLI Dagani Jssica Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Il Sorvglia Pazint (Th Patint Monitor) RIZZOLI Falcioni Stfano Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Gntic prdisposition in acquird thrombotic thrombocytopnic purpura MAGGIORE Mancini Ilaria Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Th dvlopmnt of a tissu nginrd prosthsis using dcllularizd blood vssls andautologous stm clls Sardgna mancuso luisa Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI MUTUAL INTERACTION OF OSTEOARTHRITIC INFLAMMATORY MICROENVIRONMENT AND BIOTECHNOLOGIES RIZZOLI Vronsi Francsca Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Growth Associatd Protin 43 (GAP43) and Major Histocompatibility Complx I (MHCI) gn dlivry to spinal motor nurons to prvnt th progrssion of Amyotrophic Latral Sclrosis (ALS) MARIO NEGRI Nardo Giovanni Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration In vitro and in vivo ffcts of static magntic filds on th orintation of rythrocyts, in ordr to dfin popl xposur risk: modling and simulation NEUROLESI Acri Giuspp Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 30 di 356

31 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th impact of light on food craving and mood: prdiction of circadian rhythm disordrs from nxt gnration squncing data. Vnto Minrvini Giovanni Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Idntification of mitochondrial DNA somatic altration in mylodysplastic syndroms and in othr hmatological malignancis: clinical impact and corrlation with xom "status". Basilicata Scarciolla Oronzo Biomdica Oncology 1 Basic Molcular Oncognsis MONC A Nw Nanostructurd Biomatrial for Vaginal Infctions Istituto Suprior di Sanita' Colon Marisa Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Strotactic Ablativ Radiothrapy (SABR) for Oligomtastatic Brast Cancr Patints: Invstigating th Immun Profil to Idntify Prdictiv Biomarkrs. C.R.O. AVIANO Trovò Marco Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Antimicrobial drug rsistanc in food producing animals. Essntial oils and suprcritical fluid xtraction: study th antimicrobial and immuno stimulating activity in livstock for rducing th us of antibiotics and nvironmntal pollution, improvmnt o IZSPLV Barbro Raffalla Biomdica Vtrinary Animal Halth ANHE Prognostic factors and diagnostic tools for th managmnt of Dngu Fvr: rol of Itrlukin 28 and diagnosis in urin sampl in a cohort of patints with acut dngu. SPALLANZANI Vairo Francsco Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Unravling th tiology of brast cancr: th viral componnt of a complx disas BRAVE Emilia Romagna Fusco Danila Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Tars as sourc of nw molcular biomarkrs of multipl sclrosis: a mtabolomics study Abruzzo Piragostino Damiana Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Phnotypic and functional charactrization of mait clls in hpatocllular carcinoma: a targt for novl immunothraputic approachs Sicilia Bucchri Simona Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 31 di 356

32 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Assssmnts of th rspons of human chronic lymphocytic lukmia clls aftr nhancd xprssion of mirs 181b/a and mir 130a in murin modls of human CLL Abruzzo Vison Rosa Biomdica Oncology 1 Basic Molcular Oncognsis MONC Dvlopmnt of a nw nrv rpair stratgy, combining collagn VI coatd conduits and adipos drivd stm clls. Vnto Cscon Matild Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS A psychosocial intrvntion cntrd on dignity (Dignity Thrapy) in patints with advancd cancr. Emilia Romagna Nanni Maria Giulia Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO IDENTIFICATION AND TESTING OF NOVEL 'DRUGGABLE' THERAPEUTIC TARGETS CAPABLE OF DRIVING ENDOGENOUS NEURAL STEM CELLS TO PROMOTE CENTRAL NERVOUS SYSTEM TISSUE REPAIR IN EXPERIMENTAL SPINAL CORD INJURY SAN RAFFAELE MILANO cusimano mlania Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Exploring th functional link btwn alpha synuclin and bta glucocrbrosidas within th global autophagylysosomal ntwork: rlvanc for arly diagnosis and pharmacological tratmnt in Parkinson's disas Umbria Chiassrini David Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Undrstanding xcitotoxic nurodgnration and disability progrssion in human and xprimntal multipl sclrosis NEUROMED Rossi Silvia Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Targting PTEN Loss in Colorctal Cancr Stm clls with combind inhibition of th MAPK and PI3K pathways REGINA ELENA Ciuffrda Ludovica Biomdica Oncology 1 Basic Tumor Cll Biology TCB Dcision making and impuls control impairmnts in alcohol dpndnc: assssmnt of cognitiv prcursors, and dvlopmnt of a nuro cognitiv tratmnt MAUGERI canssa nicola Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 32 di 356

33 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Linking th immun systm to cortical xcitability in multipl sclrosis: implications for pilpsy and slp NEUROMED ALBANESE MARIA Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Unravlling th cllular pathways associatd with uromodulin mutations to idntify nw thraputic stratgis for tubulointrstitial rnal disordrs SAN RAFFAELE MILANO SCHAEFFER Clin Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Rtinoic acid and hypoxia signaling in acut myloid lukmia as a nw axis for thraputic intrvntion SAN RAFFAELE MILANO Coltlla Nadia Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Molcular and functional charactrization of circulating and tissu infiltrating Th1/17 clls in Multipl Sclrosis. MAGGIORE Paroni Moira Biomdica Immunology Cllular and Molcular Immunology A CMIA Exploring synaptic plasticity through non invasiv brain stimulation to undrstand th mchanisms of disas progrssion in Multipl Sclrosis SANTA LUCIA Mori Francsco Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Prclinical valuation of nhancd cll killing in prostat cancr through combinational targting with antibodyguidd toxin(s) and pharmacutical drugs. Vnto Pastto Matto Biomdica Oncology 1 Basic Tumor Cll Biology TCB Inducibl pluripotnt stm (ips) cll drivd human astrocyts as a nw disas modl to shd light into th molcular pathognsis of mgalncphalic lukoncphalopathy with subcortical cysts (MLC). Istituto Suprior di Sanita' Lanciotti Angla Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Childhood maltratmnt and risk for dprssion: a prclinical longitudinal study to uncovr nw thraputic targts and arly prdictiv biomarkrs SANTA LUCIA Lo Iacono Luisa Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 33 di 356

34 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nurobiological modulators of abrrant motivation: promising targts of tratmnt and prvntion in psychopathology SANTA LUCIA Latagliata Emanul Biomdica Brain Disordrs and Claudio Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA A nw mous modl for Glycogn Storag Disas typ 1b: an indispnsabl tool to undrstand th pathophisiology of th disas and to dvlop nw thrapis. GASLINI Rsaz Robrta Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Rlationship btwn cognitiv rsrv and cognitiv impairmnt in pilpsy: a study of cortical plasticity and functional connctivity by transcranial magntic stimulation Toscana Giovannlli Fabio Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Prdicting microrna basd thrapis by using gn xprssion data drivn microrna mrna intractom Sicilia Coronnllo Claudia Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Nurodgnration and protin misfolding in HIVassociatd nurocognitiv disordr: undrstanding th functional rol of HIV 1 matrix protin p17 to dsign novl thraputic intrvntions. MARIO NEGRI CACCURI FRANCESCA Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Inhibition of protin kinas CK1a as a novl thraputic stratgy to targt multipl myloma progrssion and th associatd bon disas Vnto Manni Sabrina Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Nw frontirs for arly intrvntion of languag disordrs: nural and gntic markrs of risk in infants MEDEA Cantiani Chiara Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG MERESSINA 2.0 upgrading th novl MEchatronic REspiratory Systm SImulator for Nonatal Application Toscana Ciantlli Massimiliano Clinicoassistnzial Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Modlling Classical Scrapi sprad in th Italian shp population: nhancmnt th ffctivnss of control policis Istituto Suprior di Sanita' Baldinlli Francsca Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 34 di 356

35 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of gntic causs and molcular mchanisms for MSA syndrom MAGGIORE Di Fonzo Alssio Barnaba Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Disscting th rol of SLC15A4 in autoimmun priphral nuropathis. ADA2 Dficincy: a nw modl of disas to study pathognic mchanisms of autoinflammation and immunodficincy SAN RAFFAELE MILANO Romano Alssandro Biomdica Cll Biology Mmbran Biology and Protin Procssing MBPP GASLINI SCHENA FRANCESCA Biomdica Immunology Cllular and Molcular Immunology A CMIA Impact of th application of GLIADEL wafrs (BCNU, carmustin) followd by tmozolomid and radiothrapy in patints with glioblastoma multiform: fficacy, toxicity and a stm cll modl to prdict rspons/rsistanc to thrapy. Friuli Vnzia Giulia Ius Tamara Clinicoassistnzial Oncology 2 Oncology CONC EXOSOME ASSOCIATED ADAM17 AS A NEW ANTI HIV 1 THERAPEUTIC TARGET Istituto Suprior di Sanita' Arnaccio Claudia Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Trajctoris of Halth and Social Car Intgration (THESIs): An Action Rsarch on th Challngs from Chronic Nurological Disas for Socity, Halth Organizations and Profssionals. Emilia Romagna LUSARDI ROBERTO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Disscting th molcular basis of SEPN1 rlatdmyopathis MARIO NEGRI Zito Estr Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST From gn to thrapy in Amyotrophic Latral Sclrosis: focus on ndothlin systm. Associazion Oasi Maria SS D'Antoni Simona Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 35 di 356

36 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Discovry of th mutations associatd with th aggrssivnss of High Risk Nuroblastoma (HR NB) patints using Whol Exom Squncing: mutation analysis for th incrasd prdiction of rlaps in HR NB patints Vnto ESPOSITO MARIA Biomdica Oncology 1 Basic ROSARIA Cancr Gntics CG Prclinical and clinical invstigation of molcular chaprons modulation as a nw thraputic stratgy for Parkinson's disas. MONDINO Ambrosi Giulia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Exploiting patint drivd tumor xnografts to prdict rspons and circumvnt th occurrnc of rsistanc to anti angiognsis tratmnts in ovarian cancr. MARIO NEGRI Dcio Alssandra Biomdica Oncology 1 Basic Agns Tumor Micronvironmnt TME Dvlopmnt of Nrv Growth Factor antagonists to trat allrgy: in vitro and in vivo valuation of novl molculs. SAN RAFFAELE MILANO Sacchtti Marta Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Extracllular matrix dynamics in Hpatitis C inducd livr fibrosis: towards a protomic atlas of th fibrotic livr SPALLANZANI Montaldo Claudia Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Molcular dtrminants of intractions btwn B Chronic Lymphocitic Lukmia clls and its host micronvironmnt: pathophysiology and novl thraputic approachs. IRCCS AOU San Martino IST (Gnova) Fiz Francsco Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Stup of a multi sit radiation dos managmnt systm for th optimization of radiological procdurs and th assssmnt of individual and collctiv radiation dos. I. O. V. Gabusi Michl Clinicoassistnzial Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Cll basd thrapy with sphingosin 1 phosphat rcptor 1 (S1PR1) xprssing macrophags for multipl sclrosis Emilia Romagna Vint Jonathan Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Disscting th gntic and pigntic bass rsponsibl for congnital disass of abrrant growth CASA SOLLIEVO SOFFERENZA PALUMBO ORAZIO Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 36 di 356

37 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prognostic and prdictiv valus of tumor infiltrating lymphocyts in patints with ductal carcinoma in situ of th brast. I.E.O. LAZZERONI MATTEO Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Human cornal ndothlium: rconstruction, rgnration and thrapis Vnto Parkh Mohit Biomdica Brain Disordrs and Nuroscinc Antrior Ey Disas AED Functional rol of mirna binding SNPs on suscptibility and clinical outcom of pancratic cancr CASA SOLLIEVO SOFFERENZA Tavano Francsca Biomdica Oncology 2 Cancr Biomarkrs Rol of mitochondria in Bipolar Disordrs: a protomic approach SANTA LUCIA Cirgia Fdrica Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nural Oxidativ Mtabolism and Dath NOMD Targting high prolifrating tumors: 4 oxo 4 HPR drivativs in th tratmnt of tripl ngativ brast cancr and lymphoma ISTITUTO TUMORI MILANO Tibrio Paola Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Targting th xtracllular PSMA domain by a radiolabld antibody fragmnt (123I scfvd2b) for Prostat cancr imaging: a pilot Phas I clinical study ISTITUTO TUMORI MILANO Frigrio Barbara Biomdica Oncology 2 Cancr Biomarkrs Innovativ stratgis to targt IL17 producing T clls during airway infctions in Cystic Fibrosis disas SAN RAFFAELE MILANO Lorè Nicola Ivan Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Dvlopmnt of a customizd numrical tool to optimiz implant dsigns and positioning total kn arthroplastis GALEAZZI Pianigiani Silvia Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS Study of systms for valuating and dcrasing potntial risks arising from human consumption of dibl inscts in ordr to dvlop food policis and achiv consumr protction. IZSVE Blluco Simon Biomdica Vtrinary Food Safty FOSA Promot social intractions and coopration in Autism via nhancd sharing of motor intntions: th rol of rward and oxytocin. SANTA LUCIA Candidi Matto Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 37 di 356

38 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Multi functionalizd nanostructurd biomatrials for th rgnration of nrvous tissus CASA SOLLIEVO SOFFERENZA Glain Fabrizio Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO From dciphring biological ntworks of cardiosphrdrivd clls (CDC) paracrin activity to cll fr thrapis for cardiac rgnration aftr myocardial infarction (MI). Sicilia GAETANI MASSIMILIANO Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Stratgis for prsrving th intgrity and function of th immatur brain: a pr clinical study. SANTA LUCIA Foti Francsca Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Prclinical optimization of bon marrow concntrat tratmnt to improv ostochondral rpair RIZZOLI Cavallo Marco Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Longitudinal high dfinition mapping of circulating immun clls in human autoimmun Typ 1 Diabts SAN RAFFAELE MILANO Vall Andra Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Rol of inflammatory rspons in Ncrotizing Entrocolitis of th prtrm infants: ffctivnss of Tolllik rcptor 4 antagonist and PPAR gamma agonist tstd in an animal modl. Toscana Corsini Iuri Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Rol of oxidativ strss in a modl of arly Alzhimr's Disas: ffcts of th CoQ10 and nvironmntal nrichmnt SANTA LUCIA D Bartolo Paola Biomdica Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Auditory and olfactory nurodgnration: chmothrapy sid ffcts and stm cll rpair Vnto ASTOLFI LAURA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Gnomic profiling of hpatocllular carcinoma for cancr vaccin dvlopmnt PASCALE Tagliamont Maria Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 38 di 356

39 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Novl Rols for th Parkinson's Disas kinas LRRK2 in Cytoskltal Dynamics S.CAMILLO Civiro Laura Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Synapss, Cytosklton and Trafficking SYN A nw arthroscopic rgnrativ tratmnt to targt kn ostoarthritis: valuation of bon marrow concntrat potntial from in vitro studis to th clinical application in a randomizd controlld trial. RIZZOLI Filardo Giuspp Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Far mmory xtinction: from animals to humans SANTA LUCIA Laricchiuta Danila Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Us of Silk fibroin nanofibrs for th in vivo rgnration of urological tissus and th dlivry of chmothraputic agnts SAN RAFFAELE MILANO Alssandrino Antonio Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Disscting th Thyroid hormon FOXE1 functional link for th dvlopmnt of novl thraputic approachs in BCC thrapy SDN Antonini Dario Biomdica Oncology 1 Basic Molcular Oncognsis MONC CRAS Controlld Rlas of Adipos drivd stm cll Scrtom in th ostoarthritic joint: on stp byond cll thrapy GALEAZZI d Girolamo Laura Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Transcranial Magntic Stimulation in th assssmnt of motor cortx xcitability and xprimntal tratmnt of rstlss lgs syndrom. Associazion Oasi Maria SS Lanza Giuspp Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS impact of Nxt Gnration Squncing analysis of gntic and pigntic modifications in had and nck oral squamous cll carcinoma Emilia Romagna asioli sofia Clinicoassistnzial Oncology 2 Cancr Biomarkrs Unravl th functional rol and th thraputic potntial of sclra stm cll in glaugoma Vnto Bifari Francsco Biomdica Brain Disordrs and Nuroscinc Antrior Ey Disas AED Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 39 di 356

40 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of 5 alpha rductas in th impact of slp disordrs on tic svrity in Tourtt syndrom Sardgna Frau Robrto Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS STEM CELL NICHE AND TUMOR ASSOCIATED MACROPHAGES: A POTENTIAL THERAPEUTIC TARGET IN CHOLANGIOCARCINOMA HUMANITAS Raggi Chiara Biomdica Oncology 1 Basic Tumor Micronvironmnt TME A NEW ALGORITHM FOR THE EARLY IDENTIFICATION AND TREATMENT OF B LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS WITHOUT KNOWN MOLECULAR ABERRATIONS, WHO MAY BENEFIT FROM MOLECULARLY DRIVEN THERAPEUTIC APPROACHES Lazio Mssina Monica Biomdica Oncology 2 Cancr Biomarkrs Vaginal infctions in HPV positiv cancr: prvntion and tratmnt basd on an intgratd approach with natural substancs.acronym: I.N.S.T.IN.C.T (Intgration of Natural Substancs Toward INfction in Crvical Tumours) Istituto Suprior di Sanita' DI VITO MAURA Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS A systm biology study invstigating th mchanisms involvd in th rduction of cardiovascular risk in dialysis patints tratd by high fficincy convctiv thrapy: looking for a thraputic targt for dialysis associatd cardiovascular disas. Puglia Simon Simona Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS A comprhnsiv prvntiv program for dmntia tailord on th nuropsychological profil of prsons with Mild Cognitiv Impairmnt: cognitiv stimulation, physical intrvntion and halthy nutrition, a randomizd controlld trial. SANTA LUCIA DI SANTO SIMONA GABRIELLA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Chronic lithium tratmnt in an animal modl of arly Alzhimr's Disas: charactrization of nuroanatomical and functional ffcts SANTA LUCIA Glfo Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 40 di 356

41 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv DUNGEON: hacking th functional architctur of Glioblastoma multiform to curb cllular invasion CASA SOLLIEVO SOFFERENZA Mazza Tommaso Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Advancd nginrd prosthss for customizd tratmnt of thoracic dformitis Toscana Ghionzoli Marco Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Imaging cognitiv rmdiation in first pisod schizophrnia: a randomizd controlld trial SANTA LUCIA Piras Fabrizio Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Effcts of physical xrcis on th pathophysiology of crbllar dysfunction in xprimntal Multipl Sclrosis SANTA LUCIA GENTILE ANTONIETTA Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Functional charactrization of mutations of th gn ncoding th cyclin dpndnt kinas inhibitor p27kip1 (CDKN1B), rsponsibl for th dvlopmnt of multipl ndocrin noplasia typ 4 (MEN4) syndrom Toscana Francsca Marini Biomdica Oncology 1 Basic Molcular Oncognsis MONC DEVELOPMENT OF MULTIFACTORIAL GENETIC PREDICTORS OF PHARMACOLOGICAL TREATMENT RESPONSE IN PATIENTS WITH SCHIZOPHRENIA Puglia Prgola Giulio Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES CROB Tataranni Tiziana Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 41 di 356

42 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Economic crisis and adhrnc to th Mditrranan dit: possibl impact on biomarkrs of inflammation and mtabolic phnotyps in th cohort of th MOLI SANI study. Molis Bonaccio Marialaura Biomdica Halthcar Dlivry and Mthodologis Halth and Halth Rlatd Bhavior of Individuals and Populations Fllowship F Cratin Transportr Dficincy: thraputic prclinical stratgis in a conditional mous modl. STELLA MARIS Casarano Manula Rita Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD COSMO COntinuum in activ Snsory MOtor human prosthsis intraction SANTA LUCIA PARADISI FRANCESCO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Small Businss Bionginring, Surgical Scincs, and Tchnology SBTS (SBIR/STTR) Impact of improvmnt in systolic and diastolic lft vntricular paramtrs on halth rlatd quality of lif in patints undrgoing transcathtr aortic valv implantation: corrlations among immdiat and longstanding chocardiographic changs, hart f MONZINO Gripari Paola Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Bio production and charactrization of an array of nanoparticls, mad of polysaccharid mtal hybrid matrics, possssing chmothraputic proprtis. Sicilia Gallo Giuspp Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO PRECISION MEDICINE FOR CHEMOTHERAPY TREATED BREAST CANCER PATIENTS: ROLE OF PI3KC2A LOSS IN PREDICTING RESPONSE TO ANTI MICROTUBULE DRUGS Pimont Marchiò Catrina Biomdica Oncology 2 Cancr Biomarkrs DEFINITION OF THE PHENOTYPIC STATE DEPENDENT IMPACT OF PERICYTES IN CANCER CELL DISSEMINATION Emilia Romagna Mangiri Domnica Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Charactrization of th molcular mchanism of action of auranofin and buthionin sulfoximin, a scalabl drug combination showing curativ potntial in th macaqu AIDS modl. Istituto Suprior di Sanita' Shytaj Iart Luca Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 42 di 356

43 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of gn xprssion rgulation in autophagymdiatd chmorsistanc in brain tumours SANTA LUCIA Pagliarini Vittoria Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Singl cll analysis by multiparamtr flow cytomtry: indntification of nw markrs for rspons and immun charactrisazion of multpil myloma patints tratd with nw drugs Emilia Romagna Brioli Annamaria Biomdica Oncology 2 Cancr Biomarkrs Prognostic significanc of th quantification of disas and mutations using Pptid Nuclic Acids in Chronic Myloid Lukmia prcursors at diagnosis and aftr 3 months of tratmnt with Tyrosin Kinas Inhibitors Pimont Fava Carmn Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Larning and Rlarning Math S.CAMILLO Bnavids Silvia Clinicoassistnzial Varla Biobhavioral and Bhavioral Procsss Cognition and Prcption CP Circulating tumor clls in squamous crvical cancr: impact on survival and molcular charactristics rsponsibl of tumor progrssion and sprad. REGINA ELENA tomao fdrica Biomdica Oncology 2 Cancr Biomarkrs FROM CELIAC DISEASE TO ENTEROPATHY ASSOCIATED T CELL LYMPHOMA : mirnas AS NOVEL PREDICTIVE BIOMARKERS OF MALIGNANT TRANSFORMATION MAGGIORE Tomba Carolina Biomdica Oncology 2 Cancr Biomarkrs Cardiac troponin aftr cardiac surgry SAN RAFFAELE MILANO Monaco Fabrizio Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Prsonality influnc on diffrnt trajctoris of morphological changs in nurodgnrativ disas. SANTA LUCIA Picrni Elonora Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Evaluation of th us of silvr nanoparticls to rduc zoonotic food born infctions (Salmonlla and Campylobactr) in th gg producing farms: assssmnt of fficacy and bnfit to risk analysis IZSVE Losasso Carmn Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 43 di 356

44 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv RNA transcriptional profiling of oral squamous cll carcinoma to idntify rliabl prognostic and prdictiv markrs for routin clinical practic. Pimont Arduino Paolo Giacomo Biomdica Oncology 2 Cancr Biomarkrs Effctivnss of tstostron rplacmnt thrapy (TRT) on prostatic gland in hypogonadal patints affctd by bnign prostatic hyprplasia (BPH) and mtabolic syndrom (MtS) Toscana Vignozzi Linda Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER Expanding th spctrum of immunothrapy rsponsiv pilpsy: idntification of novl nuronal surfac antibodis and charactrization of thir targt antigns in patints with antipilptic drug rsistant pilpsy DON GNOCCHI Iorio Raffal Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Targting aortic valv calcification: rol and thraputic potntial of pyrophosphat. Vnto Rattazzi Marcllo Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Th us of satllit data to stimat th short trm halth ffcts of air pollution in proximity of industrial sits in Italy Lazio Badaloni Chiara Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS METABOLIC COMORBIDITIES IN PATIENTS WITH CHRONIC URTICARIA Lazio caldarola giacomo Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Dfining th xprssion profils of micrornas in pancratic islts, in immun cll infiltrats and in srum sampls of NOD mic and in sra of typ 1 diabtic patints: a rol for micrornas as candidat biomarkrs of autoimmun diabts Toscana Sbastiani Guido Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Vnous thrombombolism in patints with hpatocllular carcinoma undrgoing livr transplantation. MAGGIORE maino albrto Clinicoassistnzial Vascular and Hmatology Hmostasis and Thrombosis HT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 44 di 356

45 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of inflammation in mood disturbancs in multipl sclrosis NEUROMED BUTTARI FABIO Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Mitochondrial calcium signaling in th control of insulin snsitivity Vnto D Stfani Digo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Th rol of ndothlial dysfunction in vnous thrombombolism (VTE): data from th populationbasd Prospctiv Study of th Vasculatur in Uppsala Sniors (PIVUS) Study Emilia Romagna Cattabiani Chiara Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR STRUCTURAL AND FUNCTIONAL INSIGHTS FOR POST TRANSLATIONAL MODIFICATIONS IN CANCER: INVESTIGATING NEW TARGETABLE PLAYERS I. O. V. molon barbara Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Idntification of novl gns involvd in Non Syndromic Intllctual Disability. A first stp for nw diagnostic tools and potntial thraputic targts. BURLO GAROFALO Faltra Flavio Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD ROLE OF EPHA3 AS POTENTIAL MOLECULAR TARGET IN MULTIPLE MYELOMA: IN VITRO AND IN VIVO EFFECTS OF A SPECIFIC MONOCLONAL ANTIBODY CROB Caivano Antonlla Biomdica Oncology 1 Basic Tumor Cll Biology TCB Combination of novl acllular nrv allografts and autografts as a complx nrv rpair. Prclinical and postsurgical valuation of nrv rgnration and Schwann cll migration. RIZZOLI Boriani Filippo Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Multidisciplinary projct to optimiz managmnt and improving survival of patints with svr spsis or sptic shock du to multidrug rsistant microrganisms. Lazio FALCONE MARCO Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 45 di 356

46 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Ectodrmal dysplasia syndroms by dfctiv nctins (nctinopathis): molcular mchanisms and clinical implications ISTITUTO DERMOPATICO DELL'IMMACOLATA Brancati Francsco Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Dvlopmnt of an intgratd databas and spac tim statistical mthodology to invstigat incidnc and clustring of childhood cancrs in 5 Italian rgions Lazio LEONE MICHELA Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Autism and prosopagnosia: invstigat th rol of oxytocin and its polymorphisms to improv fac procssing, mmory and motional contagion. SANTA LUCIA Minio Palullo Ilaria Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Prdicting post surgry complications in patints undrgoing coronary artry bypass graft through th assssmnt of prioprativ cardiovascular control indics SAN DONATO Bari Vlasta Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Crayfish plagu: molcular pidmiology of Aphanomycs astaci infctions in th Italian nativ crayfish spcis Austropotamobius pallips and in nonnativ crayfish populations that may act as rsrvoirs of infctions IZSAM Caprioli Riccardo Biomdica Vtrinary Animal Halth ANHE SIGNALING TO INVADOPODIA: THE ROLE OF SNARE PROTEINS IN LEUKEMIA DISSEMINATION I. O. V. Larghi Paola Biomdica Oncology 1 Basic Tumor Cll Biology TCB Rol of macrophags in th obsity associatd colorctal cancr (CRC): sarching for nw thraputic targts. I. O. V. Mazzon Cristina Biomdica Immunology Innat Immunity And Inflammation III Tackling maladaptiv cortical oscillations: combining thalamocortical dysrhythmia, machin larning and nurofdback to xrt pain control and rduction. SANTA LUCIA Valntini Elia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Tl Hom Mdicin Rhabilitation (THoMR) approach for crbllar disordrs, combining non invasiv crbllar stimulation, computr basd platform training and tlmonitoring. MAGGIORE Frrucci Robrta Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 46 di 356

47 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Cost ffctivnss of lung cancr primary and scondary prvntion Toscana Carrras Giulia Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Mtabolic rgulation of prostat cancr malignant phnotyp Campania Trracciano Danila Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Chmoprvntion as a stratgy to hampr cancr stm cll phnotyp in inflammation drivn colon and brast tumors Emilia Romagna Pnzo Marianna Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Evaluation of th mchanisms sustaining th capability of ndognous nural stm clls to protct from ischmic strok by rstraining th pro inflammatory ffcts of dangr signals. SAN RAFFAELE MILANO Butti Erica Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Study of th cology of antibiotic rsistanc sprad through go mapping and sourc attribution as ky factor for an accurat risk assssmnt and managmnt of Italian watr bodis IZSVE Lttini Antonia Anna Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR ''ETHICLAB'': A NEW BIOBANK TO PROMOTE LABORATORY ANIMAL TISSUE SHARING Istituto Suprior di Sanita' Stt Antonio Biomdica Vtrinary Animal wlfar ANWE A nw promising tratmnt to slctivly modulat th inflammatory rspons of microglia/macrophags in spinal cord injury MARIO NEGRI Rossi Filippo Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Synaptic and non synaptic plasticity in crbllar nurons in rspons to inflammation SANTA LUCIA Grasslli Giorgio Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT A CONTROLLED DELIVERY SYSTEM FOR HUMAN ENDOTHELIAL PROGENITOR CELL CONDITIONED MEDIUM AS A NEW POSSIBLE ALTERNATIVE TO CELL THERAPY IN TISSUE REGENERATION Toscana Flic Francsca Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 47 di 356

48 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th xtracllular matrix protin EMILIN2 as a rgulator of th nutrophil rspons in th tumor inflammatory micronvironmnt during colon cancr dvlopmnt. C.R.O. AVIANO Andruzzi Eva Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Non invasiv valuation of portal hyprtnsion in patints with livr cirrhosis by using a computational modl Sicilia D'AMICO MARIO Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Rol of HLA G polymorphism in pdiatric Multipl Sclrosis BURLO GAROFALO Clsi Fulvio Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Intrconnctd ntworks of promotrs: a nw tool for prioritizing disas gns Toscana Di Patti Francsca Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Rol of TGFß signaling in th onst of Alzhimr s Disas: novl insight from Emilin protins NEUROMED D'Andra Ivana Biomdica Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Nxt gnration squncing to spd up diagnosis and to idntify novl causs of atypical hmolytic urmic syndrom MARIO NEGRI Ml Catrina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD SERPINB3 AND DEREGULATION OF MYC ONCOGENE IN LIVER CARCINOGENESIS Vnto Turato Cristian Biomdica Oncology 1 Basic Molcular Oncognsis MONC Dvlopmnt of a mirna 103 basd diagnostic kit for crbral ischmia. SDN PIGNATARO GIUSEPPE Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN MICIA Microbiom Idntity Card for Importd Animals. A Pilot study for th Microbiom Survillanc Associatd with Exotic Animal Trad IZSAM Lorusso Alssio Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 48 di 356

49 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Altrnativ in vitro modls for assssing non ssntial trac lmnts (NOTEs) dvlopmntal toxicity: transcriptomic and mtabolomic approach in farm animal cll lins and mbryos, and translational rsarch for human dvlopmntal toxicology. IZSPB Rutigliano Lucia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular, Molcular and Intgrativ Rproduction CMIR Brain AKTion: nurobiology of AKT 1 and AKT 2 and its rol in th pathophysiology and tratmnt of schizophrnia and bipolar disordr Toscana Palumbo Sara Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Cardiac rmodlling in th Dravt Syndrom: gnotypphnotyp corrlations from mous modls to patintdrivd cardiac myocyts CARLO BESTA Trragni Bndtta Biomdica Cardiovascular and Rspiratory Scincs Elctrical Signaling, Ion Transport, and Arrhythmias ESTA Study of nuroprotctiv ffcts of dxpramipxol in modls of crbral ischmia Toscana Muzzi Mirko Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP A nw multidisciplinary approach for assssing pain and distrss in mic and rats following invasiv surgry IZSVE Di Martino Guido Biomdica Vtrinary Animal wlfar ANWE Molcular mchanisms of immunomodulant ffct of msnchymal stromal clls (MSCs) on survival and prolifration of tumor clls SAN MATTEO Mantlli Mlissa Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Disscting th human immun rspons to Mycobactrium tubrculosis hparin binding hmagglutinin (HBHA) for a mor accurat diagnosis and prvntion of tubrculosis Istituto Suprior di Sanita' Mariotti Sabrina Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP EFFECT OF GLUCO AND LIPOTOXICITY ON GLP 1 SECRETION AND L CELL FUNCTION Sicilia Urbano Francsca Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE ANTI INFLAMMATORY AND NEUROPROTECTIVE ACTION OF IBUDILAST IN HUNTINGTON DISEASE SANTA LUCIA Paldino Emanula Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 49 di 356

50 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th hypoxic micronvironmnt rprograms macrophag and dndritic cll functions in nuroblastoma: mchanisms of tumor progrssion GASLINI Raggi Fdrica Biomdica Oncology 1 Basic Tumor Micronvironmnt TME High throughput profil of micrornas and protomic analysis of hpatocllular carcinomas and non Hodgkin's lymphomas inducd by Hpatitis C Virus chronic infction Toscana Gragnani Laura Biomdica Oncology 1 Basic Cancr Etiology CE Invstigating insrtional mutagnsis as a nw mchanism of HIV 1 prsistnc in infctd host SAN RAFFAELE MILANO Csana Danila Biomdica AIDS and Rlatd Rsarch AIDS Molcular and Cllular Biology AMCB Dvlopmnt of a human multifunctional anti CEACAM1/IL 2 immunoprotin in ordr to dirct and strongly fir up th immun systm's rspons against mlanoma Istituto Suprior di Sanita' Ascion Alssandro Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Targting molcular mchanisms rsponsibl for adaptation of cancr clls to mtabolic strss as a novl approach in BRAF drivn human malignancis CROB Sisinni Lornza Biomdica Oncology 1 Basic Tumor Cll Biology TCB Insulin rsistanc: insights from ntwork gnomics and molcular gntics into th mtabolic and cardiovascular phnotyp. A study in halthy individuals, in patints with nwly diagnosd typ 2 diabts and in patints undrgoing bariatric surgry. Vnto Dauriz Marco Clinicoassistnzial Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Improving of safty and fficacy of antisns oligonuclotids using biocompatibl and biodgradabl nanoparticls as dlivry systm for xon skipping mdiatd thrapis for nuromuscular disordrs. OSPEDALE BAMBINO GESU' Passarlli Chiara Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD MicroRNAs: mrging playrs in modulating pntranc from ADOA to ADOA+. S.CAMILLO Grspi francsca Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 50 di 356

51 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv An intgratd microrna profiling and Surfac Enhancd Raman Spctroscopy analysis of urin sampls to prdict prostat cancr prognosis. C.R.O. AVIANO Crvo Silvia Biomdica Oncology 2 Cancr Biomarkrs Molcular pathways in papillomavirus infctions in larg and small ruminants IZSSA Russo Valria Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F EFFECT OF A BCI CONTROLLED HUMANOID ROBOT ON INDEPENDENCE AND QUALITY OF LIFE IN ALS PATIENTS Sicilia Spataro Rosslla Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Novl Approachs to Idntify, Track and Spcifically Targt Acut Myloid Lukmia Foundr Mutations SAN RAFFAELE MILANO Vago Luca Aldo Biomdica Oncology 1 Basic Edoardo Molcular Oncognsis MONC Muscl stm clls and xtracllular matrix in obsity rlatd sarcopnia: nw insights for innovativ diagnostic and traputic approachs Vnto Franzin Chiara Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Potassium channls as nw thraputic targt for brain tumors. NEUROMED Catalano Myriam Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Longitudinal 36 months prospctiv study aimd at xploring novl biomarkrs and radiation fr tchniqus usful to th arly diagnosis, to th assssmnt of longtrm outcom and to th arly valuation of rspons to thrapy of Bhçt s disas Toscana Talarico Rosaria Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun On farm wlfar indx valuation for th Italian havy pig IZSLER ROTA SARA Biomdica Vtrinary Animal wlfar NODARI ANWE Exprssion and function of nuclotid mtabolizing ctonzyms in th contxt of multipl myloma nich in th bon marrow GASLINI Morandi Fabio Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 51 di 356

52 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Fasibility of using Brain Computr Intrfac for rhabilitation of spatial nglct S.CAMILLO Tonin Luca Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT EFFECT OF NEURO AD, COMBINED rtms STIMULATION AND COGNITIVE TRAINING, ON THE COGNITIVE FUNCTION OF PD WITH MILD COGNITIVE IMPAIRMENT S.CAMILLO Biundo Robrta Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Prsnc, bioaccumulation and toxicological risks from pharmacuticals in marin bivalvs IZSUM STRUBBIA SOFIA Biomdica Vtrinary Food Safty FOSA mirnomics of nurodgnrativ dmylination: dvlopmnt of progrssiv MS animal modls CARLO BESTA Cordigliri Chiara Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Intractions btwn gntics and brain function in th amyotrophic latral sclrosis (ALS) frontotmporal dmntia (FTD) continuum: a Whol Gnom Nuroimaging Association Study to idntify novl biomarkrs of nurodgnration SDN Trojsi Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Assssing th rol of Androgn Rcptor (AR) in th prognosis and tratmnt of brast cancr Pimont Castllano Isablla Biomdica Oncology 2 Cancr Biomarkrs D micro CT and FEA to optimiz biomatrial prformanc in ostoporosis thrapy Istituto Suprior di Sanita' Pcci Raffalla Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI RAD: Rhabilitation, Art & Dyslxia SANTA LUCIA Galli Giulia Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Circulating microrna as prdictiv biomarkrs in prdiabtic and diabtic complications Vnto CATTELAN ARIANNA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 52 di 356

53 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv CXCR4 mutants in Warts, Hypogammaglobulinmia, Infctions and Mylokathxis (WHIM) and Waldnstrom Macroglobulinmia (WM) pathognsis: signalling proprtis and thraputic opportunitis Natural killr clls and macrophags cross talk in th pathognsis of HIV 1 infction UNRAVELLING THE ROLE OF IMMUNE DERIVED OXYSTEROLS IN THE MAINTENANCE OF BREAST CANCER STEM CELL POPULATION IN VITRO AND IN VIVO HUMANITAS Borroni Elna Monica Biomdica Immunology Innat Immunity And Inflammation III HUMANITAS savino bndtta Biomdica Immunology Immunity and Host Dfns IHD SAN RAFFAELE MILANO Soncini Matias Cristobal Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Th ADRIAS study: Arthropod born Disass in Rsidnts, Immigrants and Animals living in Sicily. IZSSI Amodio Emanul Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS R programming of tumor mtabolism by fasting as a stratgy to nhanc chmothrapy ffctivnss GASLINI Bianchi Giovanna Biomdica Oncology 1 Basic Tumor Cll Biology TCB EVALUATION OF THE PROGNOSTIC AND PREDICTIVE VALUE OF ION CHANNELS AND TRANSPORTERS PROFILE ("TRANSPORTOME") IN GASTRIC CANCER. Toscana LASTRAIOLI ELENA Biomdica Oncology 2 Cancr Biomarkrs Functional dissction of inflammatory gn nhancrs in macrophags I.E.O. OSTUNI RENATO Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Nw stratgis to control vtrinary drug rsidus in food IZSUM Saluti Giorgio Biomdica Vtrinary Food Safty FOSA Rol of strogns and thir rcptors in aldostron synthsis in humans. Vnto Caroccia Brasilina Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 53 di 356

54 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv SRB1/ABCA1 cross talk as a possibl nw playr in Rtt syndrom pathognsis Toscana STICOZZI CLAUDIA Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Animal human concordanc for brast cancr in national intrst sits: a mattr of food safty, short chain and living ara. IZSME Srp Francsco Paolo Biomdica Vtrinary Food Safty FOSA St up of a nw class of anti tumour compounds basd on th fusion of proton pump inhibitors with scaffold molculs including carbonic anhydras inhibitors or standard chmothraputics Istituto Suprior di Sanita' IESSI Elisabtta Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Validation of an autoantibodis basd tst in th diagnosis of th brast cancr MAGGIORE Dspini Luca Clinicoassistnzial Oncology 2 Cancr Biomarkrs Facing th pidmics of Cliac Disas sinc th arly days: a larg scal study of pigntic and nvironmntal risk factors. Campania GALATOLA MARTINA Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Immunorgulatory rol of innat immunity clls in th tumor micronvironmnt IRCCS AOU San Martino IST (Gnova) Vacca Paola Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT STABILITY AND INSTABILITY OF ATHEROSCLEROTIC PLAQUES: THE BLOODSTREAM DISCLOSURE OF THE PROBLEM Puglia Scicchitano Pitro Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Influnc of Diffrnt Prfusion and Aortic Clamping Tchniqus in Minimally Invasiv Mitral Valv Surgry: A Randomizd Trial Pimont Ricci David Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 54 di 356

55 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv NEW APPROACHES FOR LEGIONELLA AND BIOFILM CONTROL IN DENTAL UNIT WATERLINE: USE OF TERPINEN 4 OL ALONE OR IN CONBINATION WITH CONVENTIONAL WATER SYSTEM DISINFECTION PROCEDURES Istituto Suprior di Sanita' Fontana Stfano Biomdica Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Unviling th potntial of Circulating Mlanoma Clls (CMCs): round trip from bnch to bdsid I. O. V. SCAINI MARIA CHIARA Clinicoassistnzial Oncology 2 Cancr Biomarkrs Primary systmic vasculitids, AthroSclrosis And HDL dysfunction (VAS ACTION) Emilia Romagna PALMISANO ALESSANDRA Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Rol of muscl intrstitial fibroadipognic prognitors in th rgulation of myofibr rspons to acut and pathological dnrvation SANTA LUCIA Madaro Luca Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration From monognic to multifactorial auto inflammatory disas: pathogntic study, pigntic changs and thraputic targts. BURLO GAROFALO Marcuzzi Annalisa Biomdica Immunology Innat Immunity And Inflammation III Dvlopmnt of a rapid drug suscptibility tst for Mycobactrium tubrculosis using lctronparamagntic rsonanc Istituto Suprior di Sanita' Piccaro Giovanni Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Idntification of gnotyp rlatd molcular targts in th vitamin D pathway for prsonalizd pharmacological tratmnts of th spinal disc disass GALEAZZI Colombini Alssandra Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS A potntial rol of ELAV RNA binding protins in th pathognsis of amyotrophic latral sclrosis (ALS) AUXOLOGICO Colombrita Claudia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 55 di 356

56 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nuroinflammation and Mvalonic Aciduria: mitochondrial damag and inflammasom involvmnt. BURLO GAROFALO Tricarico Paola Maura Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nural Oxidativ Mtabolism and Dath NOMD Circulating Tumor Clls in prostat cancr patints: idntification of nw rspons prdictiv markrs to androgn dpltion thrapy. I.E.O. Musi Gnnaro Clinicoassistnzial Oncology 2 Cancr Biomarkrs Immun rspons rgulation by long non coding RNA and micro RNA in rhumatoid arthritis and juvnil idiopathic arthritis Toscana santarlasci vronica Biomdica Immunology Cllular and Molcular Immunology A CMIA Circulating micrornas as novl biomarkrs of disas and rspons to thrapy in pdiatric mdulloblastoma OSPEDALE BAMBINO GESU' Mastronuzzi Angla Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Rol of tumor drivd oxystrols in monocytic cll fat within th tumor micronvironmnt. Rsistanc to HIV 1 protas inhibitors: gnotypic and phnotypic valuation of th impact of gp41 nv mutations. SAN RAFFAELE MILANO Raccosta Laura Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Lombardia Franztti Marco Biomdica AIDS and Rlatd Rsarch AIDS Molcular and Cllular Biology AMCB Towards a physiological cur of Diabtic Rtinopathy: prvntion/rgrssion by tratmnt with Chromogranin A fragmnt Vasostatin 1 SAN RAFFAELE MILANO Mastroni Silvia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Diabts, Mtabolism, Nutrition and Obsity Small Businss SEP (EMNR E10 B) Functional connctivity changs aftr Traumatic Brain Injury: MEG and fmri studis SANTA LUCIA Btti Viviana Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP A novl, pptid basd, optical diagnostic tool to idntify and quantify microrganisms in biofilm associatd infctions Toscana Di Luca Mariagrazia Biomdica Bionginring Scincs and Tchnologis Microscopic Imaging and Spctroscopy MIS* Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 56 di 356

57 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Epigntic modulation of th C9ORF72 promotr in patints affctd by amyotrophic latral sclrosis (ALS), frontotmporal lobar dgnration (FTLD) and ALS/FTLD and possibl thraputic implications Lombardia Mosca Lorna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Effcts of th antiparkinsonian drug Pramipxol on th dvlopmnt of compulsivity in rats: modulation of hippocampus vntral striatum loop by chronic stimulation of dopamin D2/D3 rcptors. SANTA LUCIA schpisi chiara Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Iodothyronins and thyromimtics: potntial applications in homozygous familial hyprcholstrolmia. Campania Silvstri Elna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Nutracuticals: potntial thraputic valu in parkinsonism NEUROMED Biagioni Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration DISCO TRIP Disrupting Rspiratory Complx I to Triggr Psudonormoxia: an anticancr stratgy Emilia Romagna Gasparr Giuspp Biomdica Oncology 1 Basic Tumor Cll Biology TCB Targting micrornas as novl anti tumor approach for KRAS mutant colorctal cancr REGINA ELENA Fiori Micol Elonora Biomdica Oncology 1 Basic Tumor Cll Biology TCB Idntification of mchanisms involvd in th pathognsis of noplastic clons in Larg Granular Lymphocyts Disordrs (LGL) Vnto Gattazzo Cristina Biomdica Immunology Cllular and Molcular Immunology B CMIB Circulating tumour clls as markrs of tumour aggrssivnss in mtastatic colorctal cancr Istituto Scintifico Romagnolo Fabbri Francsco Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Longitudinal prospctiv study of nurodgnrativ Langrhans cll histiocytosis (ND LCH): a multidisciplinary approach. Toscana Sini Elna Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 57 di 356

58 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt of a tridimnsional in vitro canin brast cancr/msnchymal Stromal Clls (MSCs) co cultur modl to rduc th us of animals in oncological studis IZSSI Di Blla Santina Biomdica Vtrinary Animal wlfar ANWE Innat immun rspons in obsity: in vitro and in vivo studis of molcular mchanisms and thraputic stratgis in nurodgnration Vnto Zusso Morna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt of gut microbiota indicators in nw stratgis for arly diagnosis and manag of childrn typ 1 dibts and irritabl bowl syndrom. Pimont Travrsi Dborah Biomdica Gns, Gnoms and Gntics Prokaryotic Cll and Molcular Biology PCMB Plant xtracts as a sourc of anti inflammatory agnts to thrat Bnign Prostatic Hyprplasia Istituto Suprior di Sanita' Marcoccia Danil Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Impact of lipid mtabolism altrations on influnza virus rplication and host cll rspons SAN RAFFAELE PISANA SGARBANTI ROSSELLA Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Transcranial MRI guidd focusd ultrasound (tcmrgfus) to trat nurological disordrs: prliminary Sicilia Gagliardo Csar Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Optimization of xtracorporal carbon dioxid rmoval through blood acidification: dvlopmnt of nw tchnologis Lombardia Zanlla Albrto Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Molcular Nanodcodrs for th Quantitativ, Multiplxd, Layr by Layr Imaging of Disas Associatd Markrs Friuli Vnzia Giulia Castronovo Matto Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO In vitro modl for cancr stm cll nich Istituto Suprior di Sanita' Bozzuto Giusppina Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 58 di 356

59 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prognostic and prdictiv significanc of liquid biopsy (Circulating Tumor Clls and cll fr nuclic acids) in nurondocrin noplasms Toscana Antonuzzo Lornzo Clinicoassistnzial Oncology 2 Cancr Biomarkrs A rcombinant antibody to CCR5 as immunothrapy against HIV transmission SAN RAFFAELE MILANO VENUTI ASSUNTA Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT A novl livr on chip approach for studying NAFLD: analysis of th mirnom associatd to th status of p53 in a 3D in vitro modl of human statosis as nw diagnostic and prognostic tool REGINA ELENA Gori Manul Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Opioids in chronic non cancr pain patints: clinical aspcts in long trm tratmnt MAUGERI CONVERSA GIANLUCA Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth and Halth Rlatd Bhavior of Individuals and Populations Fllowship F Protomic and mtabolomic charactrization of th rnal and cardiovascular impairmnt in HIV patints: nw tools to discriminat th impact of th virus, th comorbiditis and th antirtroviral drugs toxicitis Puglia Papal Massimo Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE BAP1 dpndnt Malignant Msothlioma: mchanisms and arly dtction Emilia Romagna GIORGI CARLOTTA Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP micrornas as Functional Markrs for Tratmnt Rfractory Lukamia SAN RAFFAELE MILANO Gntnr Brnhard Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Control of TGFß pro mtastatic activitiy by targting th pro angiognic Growth and Diffrntiation Factor 5 (GDF5) in th progrssion of brast cancr. Toscana Laurnzana anna Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Curcumins and RNA mtabolism: invstigating th involvmnt of coding and non coding RNA in Alzhimr's disas MONDINO Gagliardi Stlla Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 59 di 356

60 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv inflammatory Crbral amyloid Angiopathy and Alzhimr's disas ßiomarkrs CARLO BESTA Piazza Fabrizio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Challnging th rol of chmothrapy in HER2 positiv arly brast cancr: PI3KCA pathways altration and rspons to noadjuvant prtuzumab trastuzumab plus ltrozol or paclitaxl in Hormon Rcptor positiv HER2 positiv brast cancr patints. I. O. V. Guarnri Valntina Clinicoassistnzial Oncology 2 Oncology CONC Intgratd analysis of ffctor/rgulatory immunrspons and microbiota in Crohn's Disas (CD) patints and in halthy rlativs with NOD2 Istituto Suprior di Sanita' Butra Alssia Biomdica Immunology Immunity and Host Dfns IHD Rlatioship btwn ndothlial prognitor clls, APOE gnotyp, and crbrovascular prfusion in Alzhimr disas Toscana Baldacci Filippo Clinicoassistnzial Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN EVALUATION OF THE ABILITY OF MESENCHYMAL STROMAL CELLS (MSCs) AND HEMATOPOIETIC STEM CELLS (HSCs) TO RESTORE RENAL FUNCTION IN A MURINE MODEL OF ACUTE EXPERIMENTAL INDUCED RENO VASCULAR DISEASE IZSSI Altomar Robrta Biomdica Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU Cll on chip modl for nw immunothrapy approach to ovrcom th rsistanc to tripl ngativ brast cancr tratmnts: th rol of intraction btwn cancr stm cll and macrophag polarization Lazio Pantano Francsco Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Disscting th rol of FUS/CHOP and EWSR1/CHOP partnrship in myxoid liposarcoma dvlopmnt. C.R.O. AVIANO Brnca Monica Clinicoassistnzial Oncology 1 Basic Cancr Molcular Pathobiology CAMP Brain PET/MRI using simultanously th absolut quantification of 18F FDG, fmri and brain structurall valuation in pr and post surgical brain tumors: is it a on stop shop to prdict outcom and driv rhabilitation? Vnto Ccchin Digo Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 60 di 356

61 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Circulating nuclic acids in colorctal cancr: nw noninvasiv tools to improv survillanc in high risk patints ISTITUTO TUMORI MILANO DELCONTE GABRIELE Biomdica Oncology 2 Cancr Biomarkrs Invstigating th rol of mitochondria ER intraction in CMT: nw insights in th biology of priphral nuropathy S.CAMILLO Giacomllo Marta Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration rlvanc of STAT3 activation in th stting of chmothrapy rsistanc: from biological charactrization to th dvlopmnt of nw stratgis to ovrcom th rsistant phnotyp in solid tumors Campania Pisanti Simona Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Mitochondrial DNA dynamics: Implications in nurodgnrativ disass S.CAMILLO Soriano Garcia Maria Eugnia Curva Biomdica Cll Biology Nuclar and Cytoplasmic Structur/Function and Dynamics NCSD Whol gnom squncing for pidmiological idntification of clinical and nvironmntal isolats of Lgionlla spp in outbrak invstigations. Work insuranc implications. INAIL Clnza Giuspp Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP Isolation and charactrization of thyroid cancr stm clls to idntify novl molcular targts in th aggrssiv thyroid tumors unrsponsiv to th currnt tratmnt Lazio Cosimo Durant Biomdica Oncology 2 Cancr Biomarkrs CMR valuation of myocardial inflammation prsistnc aftr acut myocarditis: prognostic rlvanc SAN RAFFAELE MILANO Esposito Antonio Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Dfinition of standard ag and gndr rlatd ultrasound rfrnc valus for joint structurs in halthy childrn. MAGGIORE filocamo giovanni Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 61 di 356

62 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Biological and clinical markrs in Major Dprssiv Disordr FATEBENEFRATELLI Calati Raffalla Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA MicroRNA Rgulation of Cardiac Stm Cll Rgnration Potntial in Diabts Mllitus Calabria Vicinanza Carla Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Undrstanding mchanisms of Myotonic Dystrophy muscl atrophy: nw thraputic approachs Lazio TERRACCIAN CHIARA Biomdica Musculoskltal, Oral and O Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Th NGF TrkA control of APP phosphorylation and procssing in rtinal ganglion clls (RGC) affctd by Alzhimr s Disas lik nurodgnration and glaucoma. BIETTI Triaca Viviana Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Adipos Drivd Stm Clls (ADSCs): Diffrntiation and Enginring for Priphral Nrv Dfct Rconstruction. Sicilia zabbia giovanni Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Dvlopmnt and validation of a mathmatical modl for stm of cntral blood prssur in normal subjcts and in patints with proximal aorta dilatation Pimont MILAN ALBERTO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI TMS application in th tratmnt of Eating Disordrs Pimont Folgatti Alssia Clinicoassistnzial Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Prothymosin alpha as a nw thraputic stratgy for improving post ischmic lft vntricular rmodling and dysfunction via G protin coupld rcptor kinas 2 (GRK2) down rgulation in th failing hart. MAUGERI CANNAVO ALESSANDRO Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 62 di 356

63 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvloping innovativ mhalth intgratd solutions for mpowring typ 2 diabtic and obs patints in rmot slf monitoring and chronic car managmnt using mobil dvics, apps, social mdia and wb basd tchnologis: th DIABESITY 3.0 fasibility, AUXOLOGICO Castlnuovo Gianluca Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Study of non coding RNAs as nw biomarkrs in cancr. Toscana Acunzo Mario Biomdica Oncology 2 Cancr Biomarkrs Us of gntic drivn dysbindin 1 (DTNBP1) variations for prsonalizd tratmnts in First Episod of Psychosis MEDEA Mru Maddalna Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Novl thraputic options for hyprtrophic cardiomyopathy: a qust for a prsonalizd, gnotypdrivn tratmnt Toscana Coppini Raffal Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Connctivity basd nural markrs to dscrib and quantify cortical plasticity inducd by motor rhabilitation SANTA LUCIA Astolfi Laura Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Th potntial of stm clls on nrv rgnration: unravling th ffct of human msnchymal stromal clls in xprimntal hypoxic ischmic brain injury. BURLO GAROFALO Valncic Erica Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurodiffrntiation, Plasticity, and Rgnration NDPR Early brain imaging and nuromonitoring combind with clinical assssmnt to prdict long trm bhavioural problms in prtrm infants. MAGGIORE D Carli Agns Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Th gntic contribution of th gamma intrfroninducibl lysosomal thiol rductas IFI30 in th immun and cntral nrvous systm in th contxt of multipl sclrosis: could it b a usful markr for prsonalizing tratmnt? SAN RAFFAELE MILANO Ottoboni Linda Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 63 di 356

64 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rsistanc to tmozolomid in glioblastoma multiform: rol of mitotic slippag and USP1 rgulatd apoptosis Emilia Romagna Fltti Albrto Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Thraputic targt of vitamin D to prvnt cardiovascular disas in CKD patints. SAN RAFFAELE MILANO Arcidiacono Trsa Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS From tissus to srum in canin mammary cancr: th rol of mirnas in an intgratd concpt of malignant tumor progrssion IZSUM Pavon Silvia Biomdica Vtrinary Animal Halth ANHE Incras of tumor drug pntration by tissuintrnalizing nanocarrirs: a novl prsonalizd stratgy for Nuroblastoma thrapy GASLINI Brignol Chiara Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT INNOVATIVE FORCEPS FOR BETTER MANAGEMENT OF PATIENTS AND REDUCTION OF COSTS IN LAPAROSCOPIC SURGERY Calabria Rizzuto Antonia Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Gomdicin of typ 2 diabts: gntic, nvironmntal and social dtrminants in th Basilicata rgion. Basilicata Cccarlli Elna Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM ENDOgnous ENDOchondral bon rgnration drivn by inspird biomatrials (ENDO2) GALEAZZI Scotti Clst Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE REGULATION OF SPLICING FACTORS DURING AUTOPHAGY AND THEIR ROLE IN NEURODEGENERATION. SANTA LUCIA valacca cristina Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Intnsiv nutritional counsling in cancr patints undrgoing radiothrapy: a randomizd controlld trial. SAN MATTEO CACCIALANZ A RICCARDO Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 64 di 356

65 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Functional and structural connctivity rarrangmnt aftr pilpsy surgry S.CAMILLO Storti Silvia Francsca Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE ISTITUTO TUMORI MILANO Platania Marco Targting KRAS mutations in NSCLC through LKB1 covulnrability Clinicoassistnzial Oncology 2 Oncology CONC Effctivnss of post prandial xrcis and training intrvntions in improving glycmic control and rducing cardiovascular rlatd complications in typ 2 diabts patints March Lucrtini Francsco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Whol gnom squncing approach for gn discovring in Common Variabl Immunodficincy (CVID) Emilia Romagna Di Pirro Valntina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Anti tumor ffcts of conjugats btwn Tumor Associatd Antigns and a novl TLR7 ligand (modifid adnin) in humanizd modls of lung cancr and mlanoma Toscana Pratsi Sara Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT MicroRNAs as biomarkrs for acut graft vrsus host disas in pdiatric patints givn allognic hmatopoitic stm cll transplantation OSPEDALE BAMBINO GESU' Brtaina Alic Biomdica Oncology 2 Cancr Biomarkrs Rol of rnal prognitors in rnal cll carcinoma formation Toscana Pird Anna Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Diagnostic stratgy proposal to idntify and trat Normal Prssur Hydrocphalus patints among snil dmntia population. Lazio Rigant Luigi Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nuroprotctiv ffcts of a natural phytochmical xtractd from Moringa olifra in an xprimntal modl of Parkinson's disas. NEUROLESI Giacoppo Sabrina Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 65 di 356

66 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv fable Favouring th Acquisition of functional Basic Locomotor primitivs for Enabling walking in childrn with crbral palsy SANTA LUCIA Iosa Marco Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Wb basd Mothrhood choic dcision aid for womn with Multipl Sclrosis (W MoMS): A proof of concpt study CARLO BESTA Giordano Andra Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Epigntic rmodling of ncx3 gn by drugs inhibiting histon dactylass (HDACs) class II A: a nw stratgy to rduc th nuronal damag in brain ischmia SDN Formisano Luigi Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Effcts of fibrat inducd mitochondria biognsis in a mous modl of progrssiv multipl sclrosis Toscana buonvicino danila Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Diagnostic and prognostic valu of contrast nhancd cardiovascular magntic rsonanc for noninvasiv dtction of cardiac involvmnt in systmic amyloidosis Toscana Barison Andra Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Th rol of HIPK2 in th diagnosis, thrapy and clinical car of crbllar ataxia SDN Anzilotti Srnlla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Targting SUMO1 tau protin intraction in Alzhimr's disas and tauopathy SANTA LUCIA Nisticò Robrt Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Prclinical biomarkrs of intrictal psychosis in pilpsy: a combind EEG/fMRI study corrlatd with pupillary rspons. S.CAMILLO Anzllotti Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rol of intrfron gamma in promoting graft vrsus host disas in allognic hmatopoitic stm cll transplantation rcipints Vnto Ugl stfano Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 66 di 356

67 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rlation btwn ndothlial prognitor clls and carotid plaqu vascularization in athrosclrosis and larg vssl vasculitids. Th rol of plaqu vascularization as markr and thraputic targt in humans and animal modls. Lombardia Ammirati Enrico Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Improving social dcision making in nurological patints with acquird sociopathy syndrom SANTA LUCIA Panasiti Maria Srna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Gnom landscap of juvnil mylomonocytic lukmia: a comprhnsiv study to idntify mchanisms rlatd to high risk of rlaps Vnto Brsolin Silvia Biomdica Oncology 1 Basic Molcular Oncognsis MONC microrna BASED APPROACHES FOR HEPATIC TUMOR PROPHYLAXIS AND THERAPY Emilia Romagna CALLEGARI ELISA Biomdica Oncology 1 Basic Molcular Oncognsis MONC Exosoms as dlivry platform for packing sirnas to study th rol of Protoglycans in th pathognsis of Alzhimr s Disas. NEUROLESI Scuruchi Michl Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Ag rlatd inflammation as a common causativ pathway in altrd glucos mtabolism and sarcopnia: charactrization of arly biomarkrs of disas and idntification of potntial thraputic targts Lazio Cont Catrina Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Toward an individualizd us of mitotan tratmnt in patints affctd by adrnocortical carcinoma: gntic profiling as tool to bttr manag patints outcom and thir quality of lif. Pimont D Francia Silvia Biomdica Oncology 1 Basic Cancr Gntics CG COMPOSITION OF GUT MICROBIOTA AND IMPACT ON IMMUNE SYSTEM RECOVERY AND ACUTE GRAFT VERSUS HOST DISEASE IN PEDIATRIC PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION Emilia Romagna Mastti Riccardo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 67 di 356

68 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Anti ischmic, anti arrhythmic and mtabolic ffct of Ranolazin in Hyprtrophic Cardiomyopathy and in animal modls of vntricular hyprtrophy Toscana Todir Giancarlo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF P glycoprotin mdiats th intractions btwn antirtrovirals and lipids: impact on th ffctivnss of HAART, lipids mtabolism and athrosclrosis in HIV tratd patints. SPALLANZANI Tmpstilli Massimo Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Possibl rol of NF kb activation by microbiom as concaus of nurodgnration in Alzhimr's disas NEUROLESI Marino Mrlo Francsca Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Dit rlatd mtabolic disass and brain function: idntification of novl clinical biomarkrs of cognitiv dclin Lazio Soric Gian Pio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Fast tuning of th immun rspons across th blood brain barrir by drug rpurposing in a prclinical stting for translation into strok thrapy SANTA LUCIA Amanta Diana Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Efficacy of th tratmnt with Bifidobactrium Brv B632 and Bifidobactrium Brv BR03 on ndocrin rspons to th oral glucos tolranc tst in pdiatric obsity: a doubl blind randomizd controlld trial Pimont Prodam Flavia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Tlomr lngth, glycomics and gntics as nw prdictiv biomarkrs to improv outcom of brast cancr patints Emilia Romagna Napolioni Valrio Clinicoassistnzial Oncology 2 Cancr Biomarkrs Small RNA sq: an innovativ tool to xplor th ky rol of cardiac and immunorgulatory mirnas in Fabry Disas. HUMANITAS Viviani Chiara Biomdica Cardiovascular and Anslmi Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 68 di 356

69 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification and charactrization of arly biomarkrs for Alzhimr's disas using x vivo monocyts NEUROLESI Frlazzo Nadia Clinicoassistnzial Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Undrstanding th languag of Schwann stromal and Nuroblastoma cll cross talk undr hypoxic and nonhypoxic conditions: an approach to improv th thrapy of nuroblastoma. Vnto Avic Sanja Biomdica Cll Biology Intrcllular Intractions ICI Brain Function Monitoring to Evaluat Efficacy and Safty of Palliativ Sdation in th Last Days Thrapy in Trminally Cancr Patints. Lazio Gian Paolo Spinlli Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI A MULTIMODAL APPROACH TO STUDY IRON ROLE IN HUNTINGTON'S DISEASE FROM CENTRAL TO PERIPHERAL DISTRICT SANTA LUCIA Sanchz Cristina Biomdica Brain Disordrs and Castanda Nuroscinc Nuroscinc and Nurodgnration Circulating micrornas' xprssions profil in gastric cancr patints as prdictor of rspons to chmothrapy tratmnts Lazio Lornzon Laura Biomdica Oncology 2 Cancr Biomarkrs A nurorgnrativ approach to Parkinson's disas basd on th modulation of crbral Rac and Cdc42 GTPass Istituto Suprior di Sanita' MUSILLI MARCO Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Immun rspons against tumor by PUFA and Orlistat in colorctal cancr DE BELLIS Favoino Elvira Biomdica Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO Kv7 CHANNEL AS A NEW MITOCHONDRIAL K+ CHANNEL IN NEURONS AND CARDIAC CELLS: EXPRESSION, FUNCTIONAL CHARACTERIZATION, AND POSSIBLE PROTECTIVE ROLE AGAINST ISCHEMIA REPERFUSION INJURY. SDN Micli Francsco Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 69 di 356

70 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Boosting Cllular MRI for Cll Thrapy Applications in Nuroimmunological Disordrs CARLO BESTA Mastropitro Alfonso Biomdica Bionginring Scincs and Tchnologis Microscopic Imaging and Spctroscopy MIS* Hart failur scrning ntwork in Calabria. A mthod to rduc hospitalization and patint migration Calabria Santis Gianluca Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF PHAg basd nanobiosnsing dtction of Bruclla spp. PHA.BIO. IZSME BORRIELLO GIORGIA Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Charactrization of immun systm in hart failur: from xprimntal modls to humans. NEUROMED Carnval Danila Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Invstigation of routs of transmission for community acquird Clostridium difficil infction (CDI) and dvlopmnt of an aptamr basd biosnsor for rapid Clostridium difficil scrning IZSME Romano Vincnza Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Typ I IFN mdiatd induction of a chmorsistant nich of tumor clls: from animal modls to humans REGINA ELENA SISTIGU ANTONELLA Biomdica Oncology 1 Basic Tumor Micronvironmnt TME , molcular and functional charactrization of som syndromic congnital crbllar disordrs OSPEDALE BAMBINO GESU' BARRESI SABINA Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Dvlopmnt, validation and Cloud basd implmntation of a Magntic Rsonanc (MR) Biomarkr of Prostat Cancr (PCa) Aggrssivnss. Istituto Oncologico Candiolo Giannini Valntina Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT Function of Natural Killr clls in typ 2 diabts mllitus and a non autoimmun diabts mllitus syndrom. MULTIMEDICA Bruno Antonino Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 70 di 356

71 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv , gntic, nurophysiological and psychological prdictors of mdication ovrus hadach and its rlaps. MONDINO Viana Michl Biomdica Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Intgratd analysis of pigntic, gntic and phosphoprotomic profils for pathway basd idntification of druggabl targts in individual glioblastoma stm lik clls Istituto Suprior di Sanita' Signor Michl Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP THE ROLE OF EXOSOMES IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS IZSPLV Grifoni Silvia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Corrlation btwn cardiovascular imaging and Mdiator xprssion in ndothlial prognitor clls: a nw diagnostic intgratd tool SDN Schiano Conctta Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Potntial fficacy of compounds influncing ractiv oxygn spcis for tratmnt of pdiatric T ALL I. O. V. silic bnussi micol Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Th complx intrplay btwn microbiota and th mucus systm in intstinal tumorignsis I.E.O. Sacchri Fabiana Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Novl thraputic prspctivs for angiodma associatd with C1 inhibitor dficincy or angiotnsin convrting nzym inhibitor tratmnt BURLO GAROFALO Bossi Flur Clinicoassistnzial Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Evaluation of ffct of mindfulnss thrapy and holistic psychothrapy on quality of lif and anxity and immun paramtrs of patints affctd by tumors. I.N.R.C.A. Ottaviani Marica Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO Evaluation of th rol of th anti JC virus (JCV) nutralizing humoral rspons in th risk stratification for progrssiv multifocal lukoncphalopathy (PML) of multipl sclrosis patints on natalizumab thrapy. SAN RAFFAELE MILANO Mancini Nicasio Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 71 di 356

72 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv DEVELOPMENT OF A NEW MOUSE MODEL ACTIVELY RECAPITULATING HUMAN PEMPHIGUS FOR THE PRE CLINICAL EVALUATION OF INNOVATIVE THERAPIES. Emilia Romagna Lotti Robrta Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Dvlopmnt of nutralinzing antibodis blocking ky stps of Staphylococcus aurus infction to b usd as combind cocktail immunothrapy. Istituto Suprior di Sanita' zamboni silvia Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Long non coding RNAs as biomarkrs and thraputic targts in multipl myloma Calabria Amodio Nicola Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Lymphoplasmacytic lymphoma: gnomic landscap and clonal volution Lombardia Roccaro Aldo Maria Biomdica Oncology 1 Basic Molcular Oncognsis MONC Autophagic vacuolar myopathis: gn idntification by nxt gnration squncing CARLO BESTA Ruggiri Alssandra Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP DISSECTING THE ROLE OF MESENCHYMAL CIRCULATING TUMOR CELLS IN COLORECTAL CANCER METASTASIS HUMANITAS CELESTI GIUSEPPE Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM INDIVIDUAL PHENOTIPIC CHARACTERIZATION OF PATIENTS WITHIN THE FRONTOTEMPORAL LOBAR DEGENERATION/MOTOR NEURON DISEASE SPECTRUM USING MULTIMODAL MRI SAN RAFFAELE MILANO Canu Elisa Clinicoassistnzial Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Molcular charactrization and targting of quiscnt cancr stm clls from colorctal cancr Istituto Suprior di Sanita' Francscangli Fdrica Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT NEURAL AND SOCIAL IMPACT OF COGNITIVE REMEDIATION TRAINING IN SCHIZOPHRENIA AND BIPOLAR DISORDER Vnto Prlini Cinzia Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 72 di 356

73 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Mucosal immunity prdictors of HPV rlatd anocrvical lsions in HIV infctd womn: an immunological study. Lombardia sabbatini francsca Biomdica AIDS and Rlatd Rsarch AIDS Associatd Opportunistic Infctions and Cancr AOIC CLINICAL AND PROGNOSTIC ROLE OF CARDIOPULMONARY EXERCISE TEST IN THE MANAGEMENT OF MODERATE TO SEVERE AORTIC STENOSIS SAN DONATO Bandra Francsco Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Transcranial dirct currnt stimulation combind with bimanual intnsiv training in childrn with unilatral crbral palsy CARLO BESTA Baranllo Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Effcts of incrtin basd thrapis on cllular markrs of ndothlial function/dysfunction (EPCs/MCPs) and on cognitiv impairmnt in typ 2 diabtic patints Abruzzo FORMOSO GLORIA Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS A NOVEL MYOELECTRIC CONTROLLED VIRTUAL REALITY INTERFACE FOR EFFECTIVE UPPER LIMB MOTOR RECOVERY OF STROKE PATIENTS SANTA LUCIA Brgr Dnis Jnnifr Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Snsorimotor Intgration SMI PRECLINICAL EVALUATION OF SMALL MOLECULE SIRT6 INHIBITORS AS CHEMOSENSITIZERS IN MULTIPLE MYELOMA IRCCS AOU San Martino IST (Gnova) ca michl Biomdica Oncology 1 Basic Tumor Cll Biology TCB Crbllar tdcs as a challng for gait rcovry in crbllar dgnrativ disass. Comparativ study to addrss tratmnt fficacy SANTA LUCIA Masciullo Marclla Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A cll basd assay to tst antifibrotic drugs CARLO BESTA Gibrtini Sara Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 73 di 356

74 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of mtabolic dfcts rlatd to intracllular lipid storag in arly onst nurodgnrativ dmntia and thir implications for diagnosis and tratmnt. Calabria Cupidi Chiara Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Charactrization of th potntial oncognic rol of gamma chain (gc) by xploring its modulatory activity on gns rlatd to growth signaling, cll cycl control and survival, and through its post transcriptional mirnasmdiatd rgulation. CROB Fusco Anna Biomdica Oncology 1 Basic Molcular Oncognsis MONC Coding and non coding RNAs in B clls from multipl sclrosis patints. SANTA LUCIA Annibali Viviana Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT (hishoc) HCV INDUCED SEIZING OF THE HOST CELL: IMPLICATIONS FOR PATHOGENESIS AND THERAPY Vnto Gualtiro Alvisi Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB "THE ROLE OF 124 IODINE/CG250 PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS" SAN RAFFAELE MILANO capitanio umbrto Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Establishmnt of thr dimnsional organoids from patint drivd colorctal cancr xnografts Istituto Oncologico Candiolo di Blasio Laura Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Long trm fficacy and safty of scond gnration antipsychotics in childrn and adolscnts: an activ pharmacovigilanc and pharmacogntic study. MEDEA Pozzi Marco Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Diagnostic accuracy and cost ffctivnss of Nxt Gnration Squncing (NGS) stratgis in th gntic tsting of Rar Orthopadic Disass RIZZOLI Pdrini Elna Clinicoassistnzial Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 74 di 356

75 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of Cardiac Stromal Clls in th pathognsis of Arrhythmognic Right Vntricular Cardiomyopathy MONZINO Sommariva Elna Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Th Stm cll secrtom for doxorubicin inducd Cardiomyopathy REgnraTion (SECRET) IRCCS AOU San Martino IST (Gnova) Tasso Robrta Biomdica Cll Biology Intrcllular Intractions ICI Novl in vitro modl approach: tissu nginring tools to study th pigntic of ndothlial clls in athrosclrosis dvlopmnt SAN MATTEO Pllgata Alssandro Biomdica Gns, Gnoms and Filippo Gntics Molcular Gntics MGA Challnging nw pigntic vulnrabilitis in human chmo rsistant brast cancr mtastasis. I.E.O. Cicals Anglo Biomdica Oncology 1 Basic Cancr Gntics CG Dprssion and adult nurognsis: a multi approach invstigation on th rol of th Wnt pathway targt gn Math1 in th pathognsis of Major Dprssiv Disordr. SANTA LUCIA Saraulli Danil Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Uppr limb impairmnt in Charcot Mari Tooth patints: valuation of motor stratgis and ffctivnss of rhabilitation tratmnts by mans of an innovativ instrumntal protocol. DON GNOCCHI Pazzaglia Costanza Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Th strok pron rat as a nw xprimntal modl of antiphospholipid syndrom: pathognic and thraputic ffcts of antibodis against diffrnt B2 glycoprotin I pitops AUXOLOGICO Chighizola Ccilia Batric Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Tumor micronvironmnt in oral squamous cll cancr (OSCC). Calabria mignogna chiara Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII Impact of insulin rsistanc on phnotyp and progrssion of Parkinson's Disas MAUGERI Pagano Gnnaro Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 75 di 356

76 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of HTR2B/G alpha/hippo signaling in progrssion and thrapy rspons of uval mlanoma IRCCS AOU San Martino IST (Gnova) Amaro Adriana Agns Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Mtaphoric spch procssing in Schizophrnia: rpairing a nural connctivity brakdown. SANTA LUCIA Ribolsi Michl Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS DCMNET Intrdisciplinary ntwork for th prognostic stratification of patints affctd by Idiopatic Dilatd Cardiomyopathy Friuli Vnzia Giulia Alksova Anta Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Gntic and antignic charactrisation of mrging ruminant pstiviruss thratning farm and animal production in an ndmic ara IZSUM Ptrini Stfano Biomdica Vtrinary Animal Halth ANHE Dp gntic and phnotypic charactrization of Autism Spctrum Disordr (ASD) familis: analysis of th nuclar and mitochondrial gnom Istituto Scinz Nurologich Rochat Magali Jan Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Can xposurs to psticids and solvnts triggr th MS rlaps? MAUGERI Oddon Enrico Clinicoassistnzial Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME Impact of carotid rvascularization on cognitiv prformancs in patints with "asymptomatic" carotid stnosis: a novl multimodal brain nuroimaging approach SANTA LUCIA Cacciari Claudia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Molcular charactrization of NSCLC tratd with tyrosin kinas inhibitors on th basis of EGFR status: snsitivity mchanisms for EGFR wild typ tumors and rsistanc markrs for EGFR mutatd disas Istituto Scintifico Romagnolo Ulivi Paola Biomdica Oncology 2 Cancr Biomarkrs Invstigating th rol of bcl 2 and cancr stm clls in non small cll lung cancr REGINA ELENA D'aguanno Simona Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 76 di 356

77 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt of doubl acting apofrritin nanoparticls for nuclar dlivry of anthracyclins in HER2 positiv brast cancr Lombardia Mazzucchlli Srna Biomdica Oncology 2 Dvlopmntal Thraputics DT Disinfctants in sustainabl aquacultur: an intgratd study of th pathological, gntic and nzymatic ffcts on aquatic organisms. IZSPLV Varllo Katia Biomdica Vtrinary Animal wlfar ANWE PUSHING STEM CELL EXTRACELLULAR VESCICLES TOWARD A NEUROREGENERATIVE ASSET MAGGIORE Barilani Mario Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurodiffrntiation, Plasticity, and Rgnration NDPR IL 27 and IL 30 rcptors as novl thraputic targts in human brast cancr GASLINI Cocco Claudia Biomdica Oncology 2 Dvlopmntal Thraputics DT DECA Dsigning adaptd Environmnt for Childrn with Autism STELLA MARIS Narzisi Antonio Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Modling TDP43 proprtis through synaptic activity: from nuronal function to nurodgnration. SANTA LUCIA Nutini Michl Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Charactrisation of diffrnt clinical phnotyps in Duchnn muscular dystrophy Istituto Scinz Nurologich Sarajlija Jasnka Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Rainbow trout as translational modl for human non IgEmdiatd immun advrs ractions to food IZSPLV Colussi Silvia Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Idntification of novl tratmnt tools for Castration Rsistant Prostat Cancr by us of a spcific dsignd Zbrafish animal modl AUXOLOGICO Dicitor Alssandra Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 77 di 356

78 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ANALYSIS OF CIRCULATING MICRORNAS IN CEREBROSPINAL FLUID OF AMYOTROPHIC LATERAL SCLEROSIS. Istituto Suprior di Sanita' PIERI MASSIMO Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Ey Movmnt Dsnsitization and Rprocssing (EMDR) thrapy in Tratmnt Rsistant Dprssion (TRD): fficacy, pigntic biomarkrs and gn xprssion profils. FATEBENEFRATELLI Minlli Alssandra Biomdica Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO Nw moral psychological tsting matrials NEUROLESI Rcupro Angla Monica Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG MicroRNA profiling for idntification of brast cancr patints at high risk to dvlop distant mtastass: uncovring clinical suitability and functional rol of micrornas in brast cancr. CASA SOLLIEVO SOFFERENZA Barbano Raffala Biomdica Oncology 2 Cancr Biomarkrs CD157 in tumor micronvironmnt crosstalk: from biology to potntial clinical applications in ovarian cancr Pimont Moron Simona Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Extracllular matrix cus and tumor angiognsis: rol of EMILIN2 in rgulating ndothlial cll bhavior C.R.O. AVIANO Paulitti Alic Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Acut coronary syndroms and clinical outcom: th rol of nitric oxid synthsis in rd blood clls MONZINO Cosntino Nicola Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Molcular and biological markrs in laryngal squamous cll carcinoma, is it tim for a nw targtd thrapy?thymidylat synthas, PI3K, PTEN, AKT, pidrmal growth factor rcptor and NOTCH ar important factors for tumor cll prolifration. Improvmn I.E.O. Tagliabu Marta Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 78 di 356

79 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Targting mirnas for thrapy and molcular imaging of chronic inflammatory disass of larg vssls ARCISPEDALE Croci Stfania Biomdica Vascular and Hmatology Vascular Biology Spcial Emphasis Panl SEVB impact of modifiabl causs of rsistant hyprtnsion: an intrvntion aimd at improving slp quality and adhrnc to tratmnt Toscana Bruno Rosa Maria Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Dvlopmnt of an Anti Corruption Controlling Systm (CCS) Through Implmntation of an Oprational Corruption Controlling Tool (OCCT) Applid to th Halthcar Procurmnt Procss. Sicilia Pitrosi Astrid Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Prfusion MRI and immunological faturs of anti Hu antibody associatd paranoplastic nurological syndrom REGINA ELENA Planton Domnico Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration STUDY OF THE USE OF ESTROGENS IN THE PHARMACOLOGICAL MODULATION OF PARVALBUMIN SYSTEM IN ANIMAL MODELS OF NEURODEGENERATION Lazio MARCHESE ELISA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Dtction of molcular fingrprinting prdictiv of human colon cancr progrssion and sarch of mirnafusion gn pairs by a Systms Biology approach CASA SOLLIEVO SOFFERENZA Panza Anna Biomdica Oncology 2 Cancr Biomarkrs Lazio Capriotti Anna Laura Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Cost ffctivnss of psychoducational tratmnt in childrn with Tourtt Spctrum Disordrs (TSD) Puglia Craig Francsco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Exploring th rol of th P2X7 purinocptor in cancr cachxia. SAN RAFFAELE PISANA Vitillo Laura Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 79 di 356

80 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv In vivo valuation of th procss of Epithlial Msnchymal and Msnchymal Epithlial transition (EMT MET) in Hpatocllular Carcinoma (HCC) dissmination and mtastasization. MAGGIORE Colombo Fdrico Simon Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Tumor infiltrating lymphocyts (TILs) and mlanoma: prognostic markrs and nw traputic targts ISTITUTO DERMOPATICO DELL'IMMACOLATA nardinocchi lavinia Biomdica Oncology 1 Basic Tumor Cll Biology TCB Nxt Gnration Squncing for th dtction of gn(s) and novl thraputic targts in psoriasis rlatd pathologis GASLINI Rusmini Marta Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Innovativ thraputhic stratgis for tratmnt of Gills d la Tourtt Syndrom and Tic Disordrs: ffcts of rptitiv Transcranial Magntic Stimulation (rtms) and transcranial dirct currnt stimulation (tdcs) Sicilia Giglia Giuspp Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nw stratgy for a high throughput scrning (HTS) with stabl shrna lntivirus infction for discovry of nw drug targts in multipl myloma. Emilia Romagna STORTI PAOLA Biomdica Oncology 1 Basic Molcular Oncognsis MONC Intgrativ profiling of rar disass by whol gnom and transcriptom squncing SAN RAFFAELE MILANO Cittaro David Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Impact of athrosclrotic markrs and functional artrial paramtrs in influncing th outcom of patints with mild modrat carotid disas. SANTA LUCIA Altamura Claudia Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Ovrcoming Drug Rsistanc in Nuroblastoma IRCCS AOU San Martino IST (Gnova) Parodi Fdrica Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Gn xprssion profiling of th crosstalk btwn glioblastoma tumor clls and ndothlial clls in noplastic angiognsis SANTA LUCIA MONGIARDI MARIA Biomdica Oncology 1 Basic PATRIZIA Molcular Oncognsis MONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 80 di 356

81 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv COMBINATION OF NEUROPHYSIOLOGICAL AND NEUROIMAGING TECHNIQUES TO INVESTIGATE ALTERED BRAIN NETWORKS AND MOTOR PLANNING SECONDARY TO TRAUMATIC BRAIN INJURY (TBI) OSPEDALE BAMBINO GESU' Gazzllini Simon Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Incrasing Valu and Rducing Wast in Biomdical Rsarch: Study Dsign, Conduct, Analysis and Publication Bias of Protocols and Fundd Projcts in Italy. Umbria Luchtta Maria Laura Clinicoassistnzial Halthcar Dlivry and Mthodologis Rsarch on Ethical Issus in Human Studis REHS Agnts baring N phnylbnzamid moitis as a novl pharmacological approach for th tratmnt of Hodgkin lymphoma ONCOLOGICO DI BARI Stolfa Diana Antonlla Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Smiquantitativ paramtrs gnratd by 68Ga DOTATOC PET/CT scan and assssmnt of somatostatin rcptors profil as prognostic and prdictiv tools in nurondocrin tumors Liguria giovannini lisabtta Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] TERT promotr mutations, xprssion and localization in diffrntiatd thyroid cancr and thyroid cancr stm clls MAGGIORE Muzza Marina Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Effcts of plasma componnts in circulating chronic lymphocytic lukmia cll survival: a rol in th B cll rcptor inhibitors ra C.R.O. AVIANO BENEDETTI DANIA Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Rol of th purinrgic rcptor P2X7 in th pathognsis of athrosclrosis. SAN RAFFAELE PISANA Gorini Stfania Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR TruHart: A novl 3D cardiac biomimtic systm fully rcapitulating adult hart physiology and muscular dystrophy pathology. MONZINO Gowran Aoif Biomdica Cardiovascular and Rspiratory Scincs Cardiovascular Diffrntiation and Dvlopmnt CDD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 81 di 356

82 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dciphring th cardiac sodium channl intractom to undrstand th molcular pathognsis of cardiac arrhythmias and to dvlop novl diagnostic and thraputic tool to prvnt suddn dath SDN Dtta Nicola Biomdica Cardiovascular and Rspiratory Scincs Elctrical Signaling, Ion Transport, and Arrhythmias ESTA Rol of intrlukin 33 in th dvlopmnt of gastritis, pithlial prolifration and gastric noplasia SAN DONATO Pisani Laura Francsca Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Rol of coronary ion channls in th crass talk btwn myocardial nds and coronary blood flow. A possibl culprit in ischmic hart disas? Lazio Mancon Massimo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Gntics of svr obsity in childrn and adolscnts: assssing th prvalnc of known Mndlian forms, and discovring nw gns associatd with monognic obsity by whol xom squncing followd by cosgrgation, cas control and functional anal Vnto Morandi Anita Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Targtd inhibition of HIV 1 Tat and Intrfron rgulatory factor (IRF) 1 physical and functional intraction as a novl anti HIV 1 thraputic stratgy. Istituto Suprior di Sanita' REMOLI ANNA LISA Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Biostatistical mthods for mta analyzing individual participant data in diagnostic and prognostic rsarch, with application to th rol of crbrospinal fluid biomarkrs in Parkinson's disas. Umbria Eusbi Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD Non pptidic ligands of G protin coupl rcptors FPRs in human glioblastomas: an immunopharmacological targt for dvlopmnt of nw thraputic approachs. Istituto Suprior di Sanita' Ricci Alssandro Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM RELATIONSHIP BETWEEN OSTEOPOROSIS AND CARDIOVASCULAR RISK IN PATIENTS WITH THALASSEMIA MAJOR Toscana Mloni Antonlla Clinicoassistnzial Vascular and Hmatology Hmatology Spcial Emphasis Pan SECHl Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 82 di 356

83 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th addition of simvastatin portal vnous infusion to cold storag solution of xplantd whol livr grafts for facing ischmia/rprfusion injury in an ara with low rat of dcasd donation Sicilia PAGANO DUILIO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT mir and mthylation status altrations in rspons to nadjuvant chmo radiothrapy in rctal cancr Istituto Scintifico Romagnolo Molinari Chiara Biomdica Oncology 2 Cancr Biomarkrs Gntic charactrization of inflammatory damag on cornal limbal pithlial stm clls and stting up of innovativ non surgical thraputic stratgis. Abruzzo Curcio Claudia Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Saf Follow up aftr EndoVascular Aortic Rpair (EVAR) with Non contrast magntic rsonanc imaging (NCMRI) and Color flow Duplx Ultrasound (CDU): Diagnostic Accuracy, Cost ffctivnss Analysis, and Impact on Patint Managmnt (th SAFEVAR study) SAN DONATO Scchi Francsco Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Prformanc valuation of clinical pathways in cancr patints: an innovativ modl of govrnanc Istituto Scintifico Romagnolo Altini Mattia Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD To study th potntial mission of cancr stm clls as arly pr cancrous traits and biomarkrs of progrssion from livr fibrosis to hpatocllular carcinoma OSPEDALE BAMBINO GESU' Cccarlli Sara Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Prtratmnt staging of gastric cancr in th ra of noadjuvant chmothrapy: a prospctiv multicntr study finalisd to validat th accuracy of MDCT and th fasibility of Computd Tomography prfusion imaging in th proprativ CT staging and rsta Toscana Mazzi Maria Antonitta Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Glial mdiatd inflammation undrlying nurodgnration in Mucopolysaccharidosis typ II pitomizs a common causal path in th dvlopmnt of major nurodgnrativ disass CASA SOLLIEVO SOFFERENZA Zalfa Maria Cristina Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 83 di 356

84 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv E.L.I.S.A. projcta multicomponnt intrvntion for End of Lif car Implmntation in nd Stag organ failur of Aging from hospital to hom I.N.R.C.A. SORVILLO FRANCESCA Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Cll signaling modulators to countract to th oncognic potntial of gonadotropins. Emilia Romagna Casarini Livio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE ipsc tchnology: a usful modl to undrstand th molcular and cllular mchanisms of aging and Parkinson's disas. OSPEDALE BAMBINO GESU' Compagnucci Claudia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Can EEG biomarkrs prdict and optimiz ffctivnss of robot assistd thrapy? MAUGERI Strpi Irma Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP An Italian study on intrmdiat lnght polyq tract xpansions: frquncy, clinical variability, and brain morphomtry of subjcts at risk for lat onst nurodgnrativ disass. CARLO BESTA Nantti Lornzo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Zbrafish: an intriguing modl to invstigat th rol of cancr stm clls in thyroid carcinomas. MAGGIORE Cirllo Valntina Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Effcts of arly sizur onst and sizur prsistnc on brain connctivity in young childrn with tubrous sclrosis complx: a diffusion tnsor and functional MR study OSPEDALE BAMBINO GESU' Moavro Romina Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Pathognsis, diagnosis and prognosis of non alcoholic fatty livr disas (NAFLD): th rol of lipid rlatd molcular inflammatory pathways in th volution to statohpatitis and in th dvlopmnt of cardiovascular disass. Nw prspctivs for a non Vnto Psc Paola Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 84 di 356

85 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv TRAIL, THE REGULATION OF BODY WEIGHT AND METABOLISM, AND ITS INTERACTION WITH THYROID HORMONES AND METFORMIN. BURLO GAROFALO Brnardi Stlla Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Function of ISWI in nucloplasm compartmnts organization and its rol in altrnativ splicing of oncognic isoforms Sicilia Onorati Maria Cristina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Allognic Hmatopoitic Stm Cll Transplantation for Rfractory Immun mdiatd Nurological Disass SAN RAFFAELE MILANO Grco Raffalla Clinicoassistnzial Vascular and Hmatology Hmatopoisis HP Mitochondrial ncphalocardiopathis: an intgratd clinical and molcular approach to implmnt th gntic diagnosis OSPEDALE BAMBINO GESU' Diodato Daria Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Targtd thrapy with Ruxolitinib in Mylofibrosis: a novl charactrization of th inflammatory micronvironmnt Emilia Romagna PALANDRI FRANCESCA Biomdica Cll Biology Intrcllular Intractions ICI Nw playrs in tubrculosis vaccin dvlopmnt: mycobactrial small rgulatory RNAs for attnuating virulnc of Mycobactrium tubrculosis SAN RAFFAELE MILANO Miotto Paolo Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Immuno Mtabolic Targting of Tumor Micronvironmnt in Ewing's Sarcoma (IMMETTE) Emilia Romagna Grisndi Giulia Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Mtabolomics and cardiovascular function in th offspring of patints with prmatur coronary artry disas: a study for th arly idntification of high risk subjcts for myocardial infarction Vnto Castaldi Biagio Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Effct of tailord communication on MMR vaccination uptak and timlinss: a Randomizd Controlld Trial Puglia Martinlli Domnico Clinicoassistnzial Halthcar Dlivry and Mthodologis Community Lvl Halth Promotion CLHP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 85 di 356

86 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Blood viscosity and thrombophilic pattrn in obstructiv slp apna SAN DONATO Baryshnikova Ekatrina Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Endovascular thrapy in acut ischmic strok: an obsrvational prospctiv study of an intr provincial Hub and Spok Modl Emilia Romagna Zini Andra Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Vibriosis in aquacultur sttings: nw tools and markrs for th control of animal disass and human xposur IZSVE CABURLOTTO GRETA Biomdica Vtrinary Animal Halth ANHE Ipr xprssion of insulin rcptor in brast cancr: rol of th transcription factors AP 2 and p53. Calabria arcidiacono biagio Biomdica Oncology 1 Basic Tumor Cll Biology TCB Rol of mlanocortin rcptors in vascular rmodling MONZINO Saporiti Fdrica Biomdica Vascular and Hmatology Vascular Biology Spcial Emphasis Panl SEVB Invstigation of th apoptosis indpndnt functions of Mcl 1 in th rgulation of mtor, LDHB and NPM1 and thir contribution to Mcl 1 drivn tumorignsis. I.E.O. Elgndy Mohamd Biomdica Oncology 1 Basic Molcular Oncognsis MONC EFFECTS OF LOW FREQUENCY STN DBS STIMULATION ON LATE EMERGING AXIAL SYMPTOMS AND COGNITION IN PARKINSON'S DISEASE. Emilia Romagna PREDA FRANCESCA Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Slction of biomarkrs actionabl with targtd agnts to dfin a bio clinical and thraputic algorithm for mtastatic colorctal cancr (MCRC) patints. Abruzzo Brura Gmma Biomdica Oncology 2 Cancr Biomarkrs Th dvlopmntal rol of th ndocannabinoid systm in mtabolic syndrom and co morbid nuropsychiatric disturbancs: fundamntal mchanisms and thraputic potntial Istituto Suprior di Sanita' Macri Simon Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 86 di 356

87 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prophylactic bilatral salpingctomy as th nw stratgy for prvnting ovarian cancrs: safty confirmation, ducational campaign and assssmnt of th prvalnc of tubal prcancrous lsions in halthy womn ar th thr ssntial stps for changing s Calabria Vnturlla Robrta Clinicoassistnzial Oncology 2 Oncology CONC Effcts of a Mditrranan styl dit on non alcoholic fatty livr disas in patints with typ 2 diabts. SDN Lutgarda Bozztto Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Diabts, Mtabolism, Nutrition and Obsity Small Businss SEP (EMNR E10 B) Idntification of th prognostic and prdictiv valu of pr spcifid biomarkrs and gn sts in stag III IV pithlial ovarian cancr spcimns from patints tratd with noadjuvant platinum taxan chmothrapy: a biomarkr sub study of GOGER 01 rand Emilia Romagna Barbiri Elna Biomdica Oncology 2 Cancr Biomarkrs Combind PET/MRI brain imaging as markr of dmntia in Parkinson's disas SDN Erro Robrto Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Targting Protin kinas C Epsilon (PKC) as a novl thraputic stratgy in Primary Mylofibrosis Emilia Romagna Masslli Elna Biomdica Vascular and Hmatology Hmatopoisis HP REDOX MECHANISMS REGULATE PROLIFERATION AND CHEMIORESISTANCE OF GASTROINTESTINAL CANCER STEM CELLS Lazio Puglisi Maria Biomdica Oncology 1 Basic Ausiliatric Tumor Cll Biology TCB Molcular bass of Fmal Epilpsy with Mntal Rtardation (EFMR) and Rtt syndrom (RTT): targting common mchanisms undrlying two X linkd nurological disordrs of young girls charactrizd by brain hypr xcitability. HUMANITAS Bassani Silvia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Synapss, Cytosklton and Trafficking SYN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 87 di 356

88 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv PROGNOSTIC VALUE OF MOLECULAR ALTERATIONS IN GASTRIC CANCER: OVERALL SURVIVAL IN PATIENTS LIVING IN CREMONA AREA WITH OVEREXPRESSION OF MET, FGFR AND OCT1 Lombardia TOPPO LAURA Clinicoassistnzial Oncology 1 Basic Cancr Molcular Pathobiology CAMP Diagnostic intgration of clinical flow cytomtry with Raman spctroscopy: an innovativ approach for diagnosis of human acut lukmia SDN Mirablli Pppino Biomdica Bionginring Scincs and Tchnologis Microscopic Imaging and Spctroscopy MIS* Rol of th adipocyt minralocorticoid rcptor in th dvlopmnt of sarcopnic obsity and comorbiditis SAN RAFFAELE PISANA Fraco Alssandra Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD Dvlopmnt and validation of a drmo pidrmal Emilia Romagna biological skin substitut for th tratmnt of svr burns PURPURA VALERIA Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Protocadhrin 19 (PCDH19) rlatd pilpsy as X linkd modl of nurological disordr: from inhritd bas to thrapy. OSPEDALE BAMBINO GESU' Trracciano Alssandra Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Rscu of Transforming Growth Factor bta 1 pathway as a nw stratgy for nuroprotction in Alzhimr's disas: rol of scond gnration antidprssant drugs Associazion Oasi Maria SS Caraci Filippo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Biology byond scond primary mlanomas in mtastatic patints tratd with Slctiv BRAF Inhibitors (SBI). ARCISPEDALE moscarlla lvira Biomdica Oncology 2 Cancr Biomarkrs Disscting suscptibility to cardiomtabolic disas in Brisighlla study using gnomic and mtagnomic approachs Emilia Romagna Rosticci Martina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Unravling th rol of Fanconi anmia protins in mitochondria for novl thraputic approachs BURLO GAROFALO Ravra Silvia Biomdica Cll Biology Nuclar and Cytoplasmic Structur/Function and Dynamics NCSD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 88 di 356

89 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Mtastatic progrssion of brast cancr: targting th insulin rcptors micronvironmnt connction Sicilia Nicolosi Maria Luisa Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM PERIOPERATIVE MARKERS AND CLINICAL FOLLOW UP OF NEUROLOGICAL AND LUNG INJURY IN INFANTS WITH CONGENITAL HEART DISEASES. Vnto Simonato Manula Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Production of autologous antign spcific T lymphocyts using ipsc tchnology. Toscana Focosi Danil Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII COronary plaqu volution: in vivo invasiv and non invasiv assssmnt of coronary PLaquE progrssion and corrlation with biohumoral markrs (COUPLE) Toscana D Catrina Albrto Raniri Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Functional discovry of nw drug targtabl gns for th cur of CRC patints C.R.O. AVIANO Rizzolio Flavio Biomdica Oncology 1 Basic Molcular Oncognsis MONC Th Annxin A5 and th obsttric outcom in gnral prgnant population: Insights into molcular and functional analysis of a novl risk factor for thrombosis and prgnancy complications. CASA SOLLIEVO SOFFERENZA Tiscia Giovanni Luca Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Mlanopsin rtinal ganglion clls and circadian rhythms: function and dysfunction in Alzhimr's disas and aging. Istituto Scinz Nurologich La Morgia Chiara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nosocomial infctions, antibiotic rsistanc and th possibl nw thraputic us of an xtract of th isothiocyanat Glucomoringin purifid by Moringa olifra sds. NEUROLESI Galuppo Maria Lttria Clinicoassistnzial Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 89 di 356

90 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Invstigating th intrplay btwn msnchymal stromal clls and hmatopoitic stm clls in lukmia dvlopmnt and outcom Emilia Romagna Ciciarllo Marilna Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Harnss th powr of RIP3 as modulator of cll dath pathways in colorctal cancr thrapy CROB pscator alssandra Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Long trm fficacy of a novl simplifid, minimallyinvasiv procdur for sinus floor lvation in th atrophic postrior maxilla: a multicntr, randomizd study. Emilia Romagna Farina Robrto Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Oral, Dntal and Craniofacial Scincs ODCS Rtntion in Car (RiC) in Prsons Living With HIV (PLWH): currnt dynamics in Italy, and valuation of a long trm sustainabl intrvntion for incrasing RiC and rducing lost to follow up. SPALLANZANI Fusco Francsco Maria Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Targtd Thrapy With or Without Nphrctomy in Mtastatic Rnal Cll Carcinoma: Liquid Biopsy for Biomarkrs Discovry ISTITUTO TUMORI MILANO Vrzoni Elna Biomdica Oncology 2 Oncology CONC A warabl myocontrolld nuroprosthsis for th rcovry of hand functions undrstanding th mchanisms of action of training mdiatd by functional lctrical stimulation in individuals with strok MAUGERI Ambrosini Emilia Biomdica Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Charactrization of human adipos tissu microbiota and its rlation with adipos tissu gn xprssion and cardio mtabolic disass AUXOLOGICO Zulian Alssandra Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO alpha4bta1 intgrin mdiatd ndothlial cll adhsion to EMILIN1 gc1q domain: implications in tissu nginrd vascular grafts C.R.O. AVIANO Capuano Alssandra Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Prclinical and clinical dvlopmnt of a novl class of ligand basd CXCR4 inhibitor cyclic pptids PASCALE Iranò Catrina Biomdica Oncology 2 Dvlopmntal Thraputics DT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 90 di 356

91 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv MicroRNA: powrfull biomarkr for monitoring and prdict rspons to proprativ chmoradiothrapy in rctal cancr patints. Vnto Martto Isacco Clinicoassistnzial Oncology 2 Cancr Biomarkrs Disscting th rol of TRIM protins as autophagy rgulators in human gntic rar disass CASA SOLLIEVO SOFFERENZA Fusco Carmla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD "Novl stratgis to combat gynacological tumors: targting of mtabolism, cll invasion and chmorsistanc" CROB AMOROSO MARIA Biomdica Oncology 1 Basic ROSARIA Tumor Cll Biology TCB Th pathognsis of Hrditary Spastic Paraplgia: rol of Endoplasmic Rticulum morphological altrations MEDEA Pndin Diana Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN BILATERAL STRIATAL NECROSIS : PHENOTYPES DELINATION AND IDENTIFICATION OF NEW GENOTYPES CARLO BESTA Tonduti David Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Charactrization of nw pathways potntially involvd in Human Hpatocllular Carcinoma prvntion and tratmnt Sicilia Micli Vital Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Th ion torrnt platform utilization for th microbial biodivrsity in primplantitis: application of a nw tchnology basd on Nxt gnration Squncing BURLO GAROFALO Mazzoni Annalisa Clinicoassistnzial Infctious Disass and Microbiology Bactrial Pathognsis BACP Mapping spatial nglct symptoms in th brain: A study combining bhavioural data, functional nuroimaging, and computational modlling SANTA LUCIA Nardo David Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Human organotypic vascularizd microfluidic 3D modls for invstigating novl ndothlial targts to prvnt bon mtastatic invasion from brast cancr GALEAZZI Arrigoni Chiara Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 91 di 356

92 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Analysis of gn xprssion nois at th singl cll lvl in lymphoblastoid cll lins (LCLs) obtaind from idntical twins dscordant for multipl sclrosis (MS), unrlatd MS patints and halthy controls. SANTA LUCIA ricigliano vito antonio Biomdica Brain Disordrs and grardo Nuroscinc Nuroimmunology and Brain Tumors CNBT Bon Marrow Fibroblast: Focus on Multipl Myloma progrssion. ONCOLOGICO DI BARI Srratì Simona Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Elucidating nuroimaging biomarkrs of vascular parkinsonism for bttr prdiction of cognitiv and bhavioral outcoms. SANTA LUCIA Assogna Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Pain control in patints with bon mtastass tratd with magntic rsonanc imaging guidd high intnsity focusd ultrasound (MR HIFU) Istituto Scintifico Romagnolo Ricci Marianna Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI ATP7B multipl rar gn variants in th suscptibility for Alzhimr's Disas. SAN RAFFAELE PISANA Bucossi Srna Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Evaluation of th anti inflammatory and immunomodulatory activity of Msnchymal Stm/Stromal Cll drivd Extracllular Vsicls in an animal modl of ulcrativ colitis OSPEDALE BAMBINO GESU' Dl Fattor Andra Biomdica Immunology Immunology Fllowships and Ara F CARDIO PUZZLE solving tool: intrprting gntic htrognity in cardiomyopathis. From singl nuclotid to singl gnom, passing through massiv paralll squncing. SAN MATTEO Favalli Valntina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Nw prspctivs for radiothrapy: dvlopmnt of a lasr basd tchnology for lctrons and gamma rays gnration. Charactrization and dosimtry towards th transfr for radiothrapy of cancr. Toscana Baffigi Fdrica Biomdica Oncology 2 Radiation Thraputics and Biology RTB PERSPECT A nw prspctiv for 99mTc Molcular Imaging Emilia Romagna CICORIA GIANFRANCO Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 92 di 356

93 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prspsin (solubl CD14 subtyp) for th diagnosis of spsis and monitoring of antibiotic tratmnt in prtrm nwborns: a multicntr prospctiv study. Toscana Poggi Chiara Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Us of granulocyt colony stimulating factor to dcras post oprativ complications aftr hpatctomy. A prospctiv multicntr, doubl blind, placbocontrolld study. Emilia Romagna Alssandro Cucchtti Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP EVALUATION OF OUTCOMES OF HIGH RISK NON MUSCLE INVASIVE BLADDER CANCER (NMIBC) UNDERGOING RE TRANSURETHRAL RESECTION (RE TUR) PLUS STANDARD TREATMENT OR TREATMENT ALONE: A RANDOMIZED PROSPECTIVE TRANSLATIONAL RESEARCH STUDY Pimont Odrda Marco Clinicoassistnzial Oncology 2 Cancr Biomarkrs Multimodal xprimntal and thortical approach for th study of th Spinal Cord in halthy and disasd subjcts SANTA LUCIA Fratini Michla Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Nw insight on intractions btwn gut microbiota and ostoporosis: an in vitro and in vivo study to dvlop novl biothraputic approachs GALEAZZI Toscano Marco Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Dvlopmnt and Disas SBDD Molcular altrations and clinical faturs associatd with progrssion of mylodysplastic syndroms to mylodysplastic syndroms/ myloprolifrativ noplasms Toscana Valncia Ana Bln Biomdica Oncology 2 Martinz Cancr Biomarkrs Study of th mchanisms rsponsibl for th incrasd brast cancr risk and rducd tumor chmosnsitivity in obs and typ 2 diabts popl: rol of th intrlukin 6 Emilia Romagna BRIGHENTI ELISA Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Circulating micrornas, lifstyl factors, and thir intraction in th atiology, diagnosis and prognosis of Soft Tissu Sarcoma MARIO NEGRI Galon Carlotta Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 93 di 356

94 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Optimizd cost fficacy of HCV tratmnt with dirctacting antivirals: a modl basd approach traind by outcoms from th ral practic Istituto Suprior di Sanita' Giovantti Marta Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Nuromodulation in pdiatric focal cortical dysplasia: focus on GABArgic transmission SAN RAFFAELE PISANA rosti cristina Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Vitamin D in th prvntion of subclinical and advancd athromatosis. BURLO GAROFALO Arcidiacono Maria Vittoria Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Nxt Gnration Squncing for gntic abnormalitis rsponsibl for Atypical Chronic Myloid Lukmia Lombardia Donadoni Carla Biomdica Oncology 1 Basic Cancr Gntics CG Monitoring th molcular volution of lung cancr by liquid biopsy to modl th propr targtd tratmnt stratgy. Sicilia Bront Giuspp Biomdica Oncology 2 Cancr Biomarkrs Innat Immunity and Natural History of Hpatitis C Virus Infction in Childrn Toscana INDOLFI GIUSEPPE Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB A Pionring Nuroadaptiv Prsonalizd Thrapy for Mmory Prsrvation SAN RAFFAELE PISANA INFARINATO FRANCESCO Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Immunognic cll dath as novl immun rspons mchanism to EGFR targtd thrapy in Colorctal Cancr I.E.O. Pozzi Chiara Clinicoassistnzial Immunology Cllular and Molcular Immunology A CMIA In sarch of nw sts of gnomic and phnotypic markrs for th diagnosis of mylodysplastic syndroms: a novl discovry approach basd on high throughput flow cytomtry and RNA squncing. CROB D'Auria Fiorlla Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 94 di 356

95 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv CELLULAR AND MOLECULAR APPROACH TO STUDY NEW PATHWAYS INVOLVED IN IMMUNE DYSREGULATION: WHOLE EXOME SEQUENCING IN IPEX LIKE PATIENTS Toscana Vignoli Marina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD A phas II, prospctiv, pilot study of anakinra in asbstosis SAN RAFFAELE MILANO Dagna Lornzo Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Multimodal invstigation of biomarkrs in patints with Alzhimr's disas DON GNOCCHI Morasso Carlo Francsco Biomdica Bionginring Scincs and Tchnologis Microscopic Imaging and Spctroscopy MIS* Prsonalizd chmothrapy for bon mtastatic NSCLC patints basd on patint spcific microfluidic in vitro scrning SAN RAFFAELE MILANO Bulotta Alssandra Clinicoassistnzial Oncology 2 Oncology CONC Priphral blast claranc analysis during induction tratmnt in patints with acut myloid lukmia Toscana Mannlli Francsco Clinicoassistnzial Oncology 2 Oncology CONC A pilot study of th clinical fficacy and safty of facal microbial transplantation for th dcolonization of hospitalizd patints harboring ntric KPC producing Klbsilla pnumonia Lombardia bisi luca Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Rsolving th privascular xtracllular matrix rgulation of pricyt drivn tumor dissmination for thraputic targting of cll micronvironmnt intractions C.R.O. AVIANO Marastoni Stfano Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Biological, clinical and nuro imaging markrs of unstabl plaqu in patints with asymptomatic carotid artry stnosis Toscana nsi mascia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A nw mous modl of spontanous prion disass: following th path from structural dtrminants to toxicity and thraputics Istituto Suprior di Sanita' Pirisinu Laura Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 95 di 356

96 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th sns of numbr in Dvlopmntal Dyscalculia STELLA MARIS Anobil Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Rduction of post MI vnts in smoking cssation programs using cigs: a randomizd controlld trial Sicilia CAPONNETT O PASQUALE Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO Evaluation of a novl nano matrial as wound drssing to prvnt surgical sit infctions causd by Mthicillin Rsistant Staphylococcus Aurus (MRSA) strains. Toscana Morandi Matto Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Financial Abilitis in pathological aging S.CAMILLO Arcara Giorgio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration NR4A in autoimmun and nurodgnrativ disas: a translational approach from mous to man Pimont Montarolo Francsca Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Prliminary Studis for Boron Nutron Captur Thrapy application to Ostosarcoma Calabria Galasso Olimpio Biomdica Oncology 2 Radiation Thraputics and Biology RTB Pro inflammatory intrlukin 18 and phosphoinositiddpndnt protin kinas 1 rgulation of cardiac contractility HUMANITAS Monasky Michll Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Diagnostic significanc and pathognic rol of anti KIR4.1 potassium channl antibodis in Multipl Sclrosis. Pimont Marntto Fabiana Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Copy numbr variations at th GFAP locus and drgulatd GFAP xprssion as possibl pathognic mchanisms causing or modifying th disas phnotyp in Alxandr disas GASLINI DI ZANNI ELEONORA Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 96 di 356

97 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prospctiv randomizd study of diagnostic accuracy comparing prostat cancr dtction by transrctal ultrasound guidd biopsy vrsus Magntic Rsonanc Imaging (MRI) with slctiv MR guidd biopsy in mn with ngativ biopsy and suspctd prostat canc I.E.O. PETRALIA GIUSEPPE Clinicoassistnzial Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU Transcranial Dirct Currnt Stimulation (tdcs) for disabling trmor rsistant to thrapy: a randomizd, doubl blind, crossovr, placbo controlld clinical trial MONDINO Pozzi Nicolò Gabril Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration MicroRNA mir 590 3p and prostaglandin F2alpha rcptor (FP) xprssion in halthy subjcts and in patints with ssntial hyprtnsion Lazio Mucci Luciana Clinicoassistnzial Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Corrlation btwn motor awarnss and motor symptoms in Parkinson's Disas: a possil rol of mntal practic Emilia Romagna FIORAVANTI VALENTINA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rol of microbial co factors in prsistncy of crvicovaginal HPV infction, virus inducd inflammation and pithlial cll damag Toscana CLEMENTE ANN MARIA Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Manipulating iron homostasis in multipl myloma: a novl stratgy of potntial thraputic valu SAN RAFFAELE MILANO Campanlla Alssandro Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Pain in kn ostoarthritis, a placbo controlld randomizd clinical trial for a nw potntial thraputic approach: magntic rsonanc guidd focusd ultrasound surgry (MRgFUS) RIZZOLI Bazzocchi Albrto Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Whol Exom Nxt Gnration Squncing in patints with Rupturd and Unrupturd Intracranial Anurysm: a pilot study to idntify gntic variants associatd with risk of anurysm ruptur (ANEURYSK). CARLO BESTA Acrbi Francsco Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 97 di 356

98 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv immun systm disrgulation and nurodvlopmntal disordrs: th sarch for priphral markrs in tourtt syndrom and arly onst psychosis Puglia PETRUZZELLI MARIA Biomdica Biobhavioral and GIUSEPPINA Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD Circulating Tumour Clls: a tool for th discovry of novl biomarkrs and drug dvlopmnt targts in bon sarcoma PASCALE Bifulco Katia Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Th rol of non coding RNAs in th dvlopmnt of athrosclrosis and vascular complications in diabts Calabria D Rosa Salvator Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Mtabolomic Fingrprint for Cognitiv impairmnt in Hyprtnsion. NEUROMED SELVETELLA GIULIO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Biomarkrs of hamorragic trasformation in patints with ischamic strok. NEUROMED Landolfi Alssandro Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration non coding RNAs as Pulmonary nurondocrin(ne) tumors biomarkrs Provincia autonoma Trnto Dl Vscovo Valrio Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Sarching for nw/undtctd viruss transmittd by nativ and invasiv mosquitos and idntification of thir cological cycl including potntial animal rsrvoirs IZSVE Ravagnan Silvia Biomdica Vtrinary Animal Halth ANHE A prspctiv longitudinal cohort study on th molcular and clinical ffcts of HIV antirtroviral tratmnt with protas inhibitors on HPV rlatd malignancis. Lombardia Mazza Francsca Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 98 di 356

99 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Indicatd prvntion with long chain polyunsaturatd omga 3 fatty acids in patints with22q11 microdltion syndrom gntically at high risk for psychosis: A randomisd, doublblind, placbo controlld tratmnt trial. OSPEDALE BAMBINO GESU' Armando Marco Biomdica Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD Intraction of nvironmntal and cological factors on spillovr risk of Wst Nil and Usutu viruss in humans in Northrn Italy IZSPLV Pautasso Alssandra Biomdica Vtrinary Animal Halth ANHE Prclinical dvlopmnt of a novl and targt spcific compound that kills mlanoma clls through a dath rcptor Emilia Romagna Truzzi Francsca Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Bon Pr Mtastatic nich: th rol of xosoms in th crosstalk btwn brast cancr clls and ostoclasts Istituto Scintifico Romagnolo Mrcatali Laura Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Thranostic applications in pancratic cancr disas: a nw way to driv targtd thrapis. Sicilia TARANTINO GAETANA Biomdica Oncology 2 ILARIA Dvlopmntal Thraputics DT Early nuromuscular and psychophysiological biomarkrs for th prvntion of falls risk in nurological disass and brain aging: Training anticipatory cognitiv brain functions SANTA LUCIA Brchicci Marika Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration ROLE OF ANOCTAMINS IN NEURO MUSCULAR DISEASES GASLINI Sondo Elvira Biomdica Cll Biology Mmbran Biology and Protin Procssing MBPP Scond and third gnration squncing in gntic diagnosis of rar disass: th modl of Marfan syndrom and rlatd disordrs Toscana Sticchi Elna Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT An lastic polymric msh as an xtrnal supports for th prvntion of intimal hyprplasia in by pass vin grafts Toscana Losi Paola Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 99 di 356

100 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th hypoxia inducibl factor (HIF) 1 alpha as a potntial targt in combination with nw drugs for th thrapy of multipl myloma. Emilia Romagna Bolzoni Marina Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Th prognostic valu of a Multidimnsional Prognostic Indx (MPI) in ldrly hospitalizd patints undrgoing cardiac invasiv procdurs Emilia Romagna BERTINI MATTEO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Idntification and charactrization of human broadly nutralizing antibodis against human coronaviruss and human parainflunza viruss SAN MATTEO Piralla Antonio Biomdica Infctious Disass and Microbiology Small Businss: Non HIV Anti Infctiv Thraputics SBN ADHD and pilpsy comorbidity: safty and risk assssmnt in childrn rciving mthylphnidat or atomoxtin tratmnt. STELLA MARIS Pllacani Simona Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD Hpatitis E, an mrging zoonotic disas: immunity, pathognsis and novl rsrvoirs. Istituto Suprior di Sanita' Di Bartolo Ilaria Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Run th risk in brast cancr: th impact of gntic risk in individual and familial dcision making procsss I.E.O. Riva Silvia Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Computr aidd tools to support idntification and connctivity of th ara of sizurs gnration in pilptic patints submittd to pr surgical intracranial EEG monitoring CARLO BESTA Bllistri Elisa Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE RE ASSESSMENT OF THE RISK FACTORS FOR INVASIVE FUNGAL INFECTION IN LIVER TRANSPLANTATION BASED ON THE MODEL FOR END STAGE LIVER DISEASE (MELD) SCORE Emilia Romagna Bartoltti Michl Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 100 di 356

101 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv NEUROMASTER: NEUROnavigatd MAgntic STimulation in patints with mild modrat Alzhimr disas combind with Effctiv cognitiv Rhabilitation SAN RAFFAELE PISANA Vcchio Fabrizio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Multipl primary tumours aftr brast cancr: th rol of nvironmnt and thrapis, and possibl gntic and pigntic risk markrs Pimont Riccri Fulvio Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Chronic Kidny Disas valuation in high risk subjcts, nphropatic patints and transplant rcipints: Diffusion tnsor imaging, Elastography, urinary micrornas and biomarkrs of Fibrosis allow Early diagnosis, rnal and Allograft survival improvmnt a Sicilia Lacquaniti Antonio Biomdica Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU Macrocphaly Autism Epilpsy Phnotyp (MAEP) spctrum: multimodal assssmnt of nuroanatomical, nurophysiological and molcular undrpinnings of brain dysfunctions. STELLA MARIS Valvo Giulia Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Controlling th liposom protin corona for its xploitation in targtd thrapy Lazio Caracciolo Giulio Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Optimization of th cardiac ntwork in th Lazio rgion: appropriatnss, timlinss and quity in accss to mrgncy car. Lazio Mataloni Francsca Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Circulating micrornas, salivary biomarkrs (micrornas, protins and microbiota) coupld to clinical and tlhomcar data as innovativ diagnostic tools for fibromialgia syndrom. OSPEDALE BAMBINO GESU' Baldassarr Antonlla Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Affctiv dysrgulation in Bipolar and Bordrlin Prsonality Disordrs: a common fatur with diffrnt pattrns. A multidimnsional study with th Exprinc Sampling Mthod and physiological monitoring. FATEBENEFRATELLI Candini Valntina Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 101 di 356

102 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Mindfulnss basd cognitiv bhavioural thrapy for obsssiv compulsiv disordr: a randomizd controlld trial on th clinical outcoms and th undrlying nural mchanisms of chang FATEBENEFRATELLI Lanfrdi Mariangla Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Coronary CT Angiography and CT prfusion imaging in Typ 2 diabtic patints with ndothlial dysfunction Lazio Pirro Fdrica Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Th novl candidat tumor supprssor gn ADAR2 as a nw thraputic targt for glioblastoma multiform (GBM) OSPEDALE BAMBINO GESU' Tomaslli Sara Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP In vitro diffrntiation of placnta stm clls into matur functional hpatocyts and in vivo application for th tratmnt of livr basd mtabolic disass Sardgna Marongiu Fabio Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP COMBINED MOLECULAR AND IMMUNOLOGICAL STRATEGIES FOR OUTCOME PREDICTION AND THERAPY OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTIONS Emilia Romagna Barili Valria Biomdica Immunology Immunity and Host Dfns IHD Invstigation of human pilptic ntworks by fmri basd ffctiv connctivity: a nw approach to idntify th nuronal drivrs of th pathological activity in surgically rmdiabl pilpsis. Emilia Romagna Vaudano Anna Elisabtta Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nanoparticls ncapsulating Zoldronic Acid in combination thrapy as a nw stratgy for glioblastoma tratmnt REGINA ELENA Porru Manula Biomdica Oncology 2 Dvlopmntal Thraputics DT Circulating micro RNAs as novl biomarkrs in Malignant Plural Msothlioma Toscana BONOTTI ALESSANDRA Biomdica Oncology 2 Cancr Biomarkrs Nural manual vs. robotic assistd mobilization to improv motion and rduc pain hyprsnsitivity in hand ostoarthritis: a randomizd controlld trial. DON GNOCCHI VILLAFANE JORGE HUGO Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 102 di 356

103 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Evaluation of th impact of functional and volumtric tools on th DIaGnostic confidnc of physicians in th diagnosis of Alzhimr's Disas (DIG AD) FATEBENEFRATELLI Rdolfi Albrto Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A proinflammatory rol of prongf and of th p75ntr rcptor in chronic arhtiris: a novl targttabl pathway for novl thrapis OSPEDALE BAMBINO GESU' Minnon Gatana Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Placnta drivd Msnchymal Stromal Clls as nw thraputic tools to dlivr anti inflammatory signals and anti tumor drugs simultanously: a prclinical study in bon sarcomas. Pimont Marschi Katia Biomdica Oncology 1 Basic Tumor Micronvironmnt TME THE ROLE OF DEEP BRAIN STIMULATION AND ITS PARAMETER OPTIMIZATION IN MOOD AND BEHAVIORAL DISTURBANCES IN PATIENTS WITH MOVEMENT DISORDERS MAGGIORE Fumagalli Manula Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A comprhnsiv approach for th diagnosis of ultra rar disass Emilia Romagna Magini Pamla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Dvlopmnt and application of a nw cas finding stratgy for rcognition of missing cass of cliac disas in Italian gnral practic Sicilia Trifirò Gianluca Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Prospctiv valuation of a scrning mthodology and of pathophysiological corrlats in patints admittd to hospital for acut coronary syndroms and at risk of chronic obstructiv pulmonary disas. Emilia Romagna CAMPO GIANLUCA CALOGERO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Risk valuation of human xposur to ticks born disass (TBDs) and comparativ analysis of pathogns through mdical and vtrinary coopration IZSUM Antognini Elisa Biomdica Infctious Disass and Microbiology Vctor Biology VB Optimizing brain pr surgical planning in childrn: intgration of functional and structural connctivity at high and ultra high fild MRI STELLA MARIS Fiori Simona Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 103 di 356

104 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A comprhnsiv stimulating program for MCI patints supportd by prvasiv halthcar tchnologis: cognitiv training, fitnss and nutritional intrvntions FATEBENEFRATELLI Fostinlli Silvia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Modling inflammation and oxidativ strss in Rtt syndrom dvlopmnt using a protomic approach to idntify arly molcular targts Toscana Cortlazzo Alssio Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Circulating mirna biomarkrs for dfating mortality in lung and ovarian cancr patints I.E.O. BIANCHI FABRIZIO Biomdica Oncology 1 Basic Cancr Gntics CG A pilot study for staging schizophrnia through a multifactor algorithm: implications for prdiction of prognosis, clinical and functional outcom of convntional drug tratmnt compard to modrn Cognitiv Rhabilitation. Puglia RAMPINO ANTONIO Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA DEFINING THE PERIPHERAL NERVOUS SYSTEM SIGNATURE IN AMYOTROPHIC LATERAL SCLEROSIS: A MAGNETIC RESONACE IMAGING AND NEUROPATHOLOGIC STUDY SAN RAFFAELE MILANO Riva Nilo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration IDENTIFICATION OF GENETIC MECHANISMS AND DISCOVERY OF BIOMARKERS IN FOCAL CORTICAL DYSPLASIA AND REFRACTORY EPILEPSY Emilia Romagna Pippucci Tommaso Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD TRFH domain of TRF2 as a targt for drug dvlopmnt REGINA ELENA Salvati Erica Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Th burdn of HIV infction and AIDS on mortality pattrns: A population basd study in Italy C.R.O. AVIANO Zucchtto Antonlla Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Randomizd controlld trial on th ffcts of mthylphnidat and add on computr basd workingmmory training, on action planning, adaptiv bhaviour and quality of lif in patints with ADHD. STELLA MARIS Blmonti Vittorio Clinicoassistnzial Biobhavioral and Bhavioral Procsss Cognition and Prcption CP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 104 di 356

105 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of pharmacokintic and pharmacognomic stratgis for mthotrxat thrapy prsonalization in patints with Juvnil Idiopathic Arthritis BURLO GAROFALO Pastor Srna Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Nw managrial paths and tchnological innovations noninvasiv for car and rmot monitoring of complxs patints: Cost bnfit analysis and hom car. NEUROLESI Bramanti Alssia Clinicoassistnzial Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI High tchnology virtual rality surgical simulators for mdical studnts' slction and young rsidnts' training in nurosurgry CARLO BESTA Prin Alsandro Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Improving cancr srvics: intgration of car valuation and patint ngagmnt modls Emilia Romagna Bravi Francsca Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD PREDICTING THE PROGRESSION OF SUBJECTIVE COGNITIVE DECLINE AND MILD COGNITIVE IMPAIRMENT (MCI) TO DEMENTIA: THE ROLE OF COGNITIVE, BIOLOGICAL AND NEUROIMAGING MARKERS Emilia Romagna spallazzi marco Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Involvmnt of bta adrnrgic signalling in cardiac rpair and rgnration Istituto Suprior di Sanita' Massimi Alssia Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF High throughput mirnaom profiling in myasthnia gravis patints: towards th idntification of pathognic mchanisms undrlying autoimmunity CARLO BESTA Cavalcant Paola Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Dciphring th rol of micrornas and gnomic altrations in mlanoma rsistanc to BRAF targtd thrapy: idntification of plasma biomarkrs to prdict and monitor rspons to thrapy ISTITUTO DERMOPATICO DELL'IMMACOLATA Caporali Simona Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 105 di 356

106 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ANTI CEACAM6 LIPOSOMAL IMMUNO CHEMOTHERAPY OF COLORECTAL CANCER IN AN ORGAN ON CHIP DEVICE SDN Tomaiuolo Giovanna Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Nurobiological mchanisms undrlying motion procssing dysfunctions in Affctiv Disordrs: A clinical and MRI longitudinal invstigation SANTA LUCIA Basil Barbara Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Th pr mtastatic nich formation in mlanoma: rol of tumor drivd scrtd factors and myloid drivd supprssor clls in modulating and shaping th nvironmnt of scondary rcurrncs and clinicopathlogical prdictors of mlanoma skip mtastass SAN GALLICANO PAOLINO GIOVANNI Biomdica Oncology 1 Basic Tumor Cll Biology TCB Dciphring candidat suscptibility gns for familial Colorctal Cancr ISTITUTO TUMORI MILANO Signoroni Stfano Biomdica Oncology 1 Basic Cancr Gntics CG Multi Omics study of spastin rlatd hrditary spastic paraplgia (HSP) typ 4 to hlp diagnosis and thrapy of diffrnt pntranc and svrity phnotyps STELLA MARIS Uccifrri Nadia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rol of th ndoplasmic rticulum rdox rgulators Ero1alpha, Proxirdoxin4 and ERp44 in prostat cancr SAN RAFFAELE MILANO Anlli Tiziana Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Gn nvironmnt intractions in th tiopathognsis of nonsyndromic craniosynostosis: towards th dfinition of an updatd diagnostic workflow Lazio FRASSANITO PAOLO Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD IMPACT ON CLINICAL OUTCOME AND COSTS OF SYSTEMATIC MULTIDISCIPLINARY MANAGEMENT OF HOSPITALIZED PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA Emilia Romagna Giannlla Maddalna Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Nw molcular biomarkrs for th diagnosis and managmnt of pancratic lsions Sicilia Bruno Lordana Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 106 di 356

107 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Combining nxt gnration squncing and cllular studis to dvlop ffctiv stratgis for th idntification of unconvntional gntic dtrminants of amyotrophic latral sclrosis Lazio Marangi Giuspp Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD PEPTIDE RECEPTOR RADIONUCLIDE THERAPY WITH 90Y DOTATOC IN RELAPSED/REFRACTORY DIFFUSE LARGE B CELL AND MANTLE CELL LYMPHOMAS. Istituto Scintifico Romagnolo Musuraca Grardo Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Nw molcular markrs for a prsonalizd thrapy in pithlial ovarian cancr C.R.O. AVIANO Songo Maura Biomdica Oncology 2 Cancr Biomarkrs Disscting th gntic tiology of pilptic ncphalopathy by nxt gnration squncing Campania Coppola Antonitta Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Exploring th potntialitis of lung ultrasound in pdiatric cardiac surgry: an asy, fast, inxpnsiv, radiation fr, but still surprisingly undrutilizd diagnostic tool. Toscana Giordano Raffal Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Idntification of molcular and cllular thraputic targts for th cur of psoriasis and inflammatory skin disass SAN RAFFAELE MILANO Maina Virginia Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Idiopathic normal prssur hydrocphalus: nw diagnostic markrs for a tratabl dmntia. Lazio POLLI FILIPPO MARIA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration i CLIMB projct: a pilot study for th intgration of CLinical, Imaging and Mchano Biological variabls as a nw paradigm for managmnt of th dilatd ascnding aorta Toscana Murzi Michl Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 107 di 356

108 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Efficacy of lymphatico vnous anastomosis alon, autologous vascularizd lymphnod transfr alon and combind lymphatico vnous anastomosis and autologous vascularizd lymphnod transfr in th tratmnt of brast cancr rlatd lymphdma Lazio Visconti Giuspp Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Familial pancratic cancr: idntification of high risk individuals.dfinition of a possibl scrning algorithm basd on clinical faturs, clinical gntics and molcular analysis. SAN MATTEO COBIANCHI LORENZO Biomdica Oncology 1 Basic Cancr Gntics CG Molcular control of inkt cll function and anrgy in anti tumor rspons SAN RAFFAELE MILANO Fdli Maya Biomdica Immunology Cllular and Molcular Immunology B CMIB In vivo advancd MRI markrs of brain micronvironmnt pron to mtastasis in brast and lung cancr patints. REGINA ELENA Quattrocchi Carlo Cosimo Biomdica Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Rout to normalization: functional and structural corrlats of dprssion rmission inducd by psychothrapy. SANTA LUCIA Tommasin Silvia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Malignant mlanoma: invstigation of nw combind targtd thrapis in in vitro and in vivo modls SDN Cuomo Gaia Biomdica Oncology 1 Basic Tumor Cll Biology TCB RApid vrsus SLOw Withdrawal of antipilptic monothrapy in two yar sizur fr adult patints with pilpsy (RASLOW Study): a pragmatic multicntr, prospctiv, randomizd, controlld study. Calabria Frlazzo Edoardo Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Prospctiv invstigation of th rlationship btwn C subunit of th FO ATP synthas and rprfusion injury in patints with ST sgmnt lvation myocardial infarction. Emilia Romagna Bonora Massimo Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 108 di 356

109 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv SIGNOR a tool for systms approach to diagnosis and patint stratification: focus on nuromuscular disordrs. SANTA LUCIA Prftto Livia Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST Cardiac prsrvation with normothrmic donor hart prfusion compard to standard cold storag in hart transplantation: a nw standard of car to fac donor shortag? Friuli Vnzia Giulia Sponga Sandro Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS Intgratd ntwork for th idntification and tratmnt of subjcts with Familial Hyprcholstrolmia for th prvntion of prmatur coronary hart disas. ARCISPEDALE Fasano Tommaso Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Early nvironmntal stimulation and Down syndrom: impact on nurodvlopmnt in childrn and animal modls STELLA MARIS Bgnisic Tatjana Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Rol of mitochondrial calcium in stomach and colorctal cancrs Emilia Romagna Marchi Savrio Biomdica Oncology 1 Basic Molcular Oncognsis MONC Application of Protomics and Mtabonomics for nurodgnrativ pathways idntification linkd to dp gray mattr atrophy and iron dposition in Multipl Sclrosis and Parkinson's Disas patints SANTA LUCIA Pisani Valrio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Incrasing diagnostic accuracy of Alzhimr s disas in th arly stag of mild cognitiv impairmnt through machin larning algorithms and functional connctivity masurs S.CAMILLO D Marco Matto Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Prdictiv impact of th immun contxtur and gnomic altrations in glioblastoma aftr dndritic cll immunothrapy CARLO BESTA Pllgatta Srna Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 109 di 356

110 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of th ansthtic block of th motor branchs of postrior tibial nrv in th valuation of th spastic quinus pattrn: validation of a surfac EMG intgratd protocol Istituto Scinz Nurologich Milltti David Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS An innovativ and transfrabl rhabilitation protocol for oncology patints with skltal rconstructions basd on warabl and portabl systms RIZZOLI Valnt Giordano Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Etiology of cryptoglandular anal fistulas: immunopathological charactrization of chronic inflammation Lazio Litta Francsco Biomdica Immunology Innat Immunity And Inflammation III rplay: a comprhnsiv rhabilitation thrapy tool basd on Activ vido gam for childrn with crbral palsy SANTA LUCIA Alois Fabio Biomdica Biobhavioral and Bhavioral Procsss Motor Function, Spch and Rhabilitation MFSR RESHAPE: REstoring th Slf with mbodiabl HAnd ProsthsEs INAIL Di Pino Giovanni Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Towards improvd survillanc and prpardnss for Wst Nil Virus infctions at th animal human intrfac IZSVE Mulatti Paolo Biomdica Vtrinary Animal Halth ANHE Dvlopmnt of a standardizd WGS basd platform for ral tim outbrak invstigation and infction control practic improvmnt. SAN RAFFAELE MILANO Baldan Rosslla Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Effcts of Transcranial Dirct Currnt Stimulation and Cognitiv Bhavioural Thrapy on brain plasticity in MS: implications for th tratmnt of chronic pain. SANTA LUCIA Spano' Barbara Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Innat Immunity and Inflammation gns: novl markrs for prtrm birth and crbral palsy BURLO GAROFALO Albrini Elna Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 110 di 356

111 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Non Invasiv brain stimulation combind with mmory training in patints with Alzhimr s Disas FATEBENEFRATELLI Brambilla Michla Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Chronic Vnous Disas: a randomizd study in subjcts with prolongd occupational xposur to gravity. Emilia Romagna GIANESINI SERGIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth and Halth Rlatd Bhavior of Individuals and Populations Fllowship F Novl bactriophags isolatd from chs manufacturing nvironmnts as innovativ tool for Listria monocytogns activ biocontrol in chs plants IZSUM Ptruzzlli Annalisa Biomdica Vtrinary Food Safty FOSA PARACETAMOL AND IBUPROFEN IN THE TREATMENT OF PATENT DUCTUS ARTERIOSUS: CLINICAL IMPACT AND BIOMARKERS OF EFFICACY IN TWO COHORTS OF PRETERM INFANTS. MAGGIORE ANTONIAZZI STEFANIA Biomdica Endocrinology, ADELAIDE Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Emrging ArBovirus infctions: pidmiology, diagnosis and pathognsis Emilia Romagna Rossini Giada Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Impact of a Comprhnsiv Griatric Assssmnt on th Eldrly Patint in Oncology: Optimization of Prsonalizd Halth Car Programs and Diagnostic Thraputic Pathways. A Randomizd Controlld Study. SAN RAFFAELE PISANA Dall'Armi Valntina Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Hindring Abta formation by targting th Amyloid Prcursor Protin at th bta scrtas clavag sit MARIO NEGRI BEEG MARTEN Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Drug Discovry in th Nrvous Systm ZRG1 MNPS Participatory rsarch for fin tuning of a 2.0 systm to optimis hom managmnt of oral cancr thrapis. Istituto Scintifico Romagnolo PASSARDI ALESSANDRO Clinicoassistnzial Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 111 di 356

112 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Validation of an Ankl Warabl Exosklton (AWE) prototyp for gait function support and rhabilitation in childrn with nurological and nuromuscular disass OSPEDALE BAMBINO GESU' Vasco Gssica Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Effct of a physical activity and halth ducation program on functional ability, physical prformanc, and halthcar rsourc consumption in ldrly subjcts with mtabolic syndrom. Lazio Laudisio Alic Biomdica Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Impact of mthylmrcury xposur on nurocognitiv function in childrn at school ag. BURLO GAROFALO mariuz marika Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Nw control stratgis of salmonllosis in pigs basd on modulation of th intstinal microbiota IZSUM Psciaroli Michl Biomdica Vtrinary Animal Halth ANHE IMPLEMENTING A POPULATION BASED RECORD LINKAGE SYSTEM OF NEUROLOGICAL DISEASES: A TOOL FOR EVALUATIVE EPIDEMIOLOGY. PARKINSON'S DISEASE AS A MODEL. Istituto Scinz Nurologich Luciano Lornza Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Undrstanding nural mchanisms of Spatial Nglct by linking anatomical damag to rsting stat functional connctivity NEUROMED Baldassarr Antonllo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration LOW ADIPONECTIN LEVELS AS INDIPENDENT RISK MARKER FOR BREAST CANCER IN HIGH RISK POSTMENOPAUSAL WOMEN I.E.O. Macis Dbora Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC SIRT1 activation as a nw stratgy to rduc ndothlial dysfunction and thrombotic vnts in htro/homozygous for Mthylnttrahydrofolat rductas (MTHFR) NEUROMED Carrizzo Albino Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR FATEBENEFRATELLI Signorini Giulia MULTIthnic orintd mntal halth srvics: a CulturAl Mdiation Portal MULTICAMPO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 112 di 356

113 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Impact of bon marrow micronvironmnt on platlt prothrombotic function: an in vitro modl basd on gntically nginrd mgakaryocyts. MONZINO Brambilla Marta Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Ral tim fmri basd nurofdback as a tratmnt tool for motional dficits in bipolar disordr. SAN RAFFAELE MILANO Poltti Sara Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Prdnisolon in cattl: OMICS stratgis to diffrntiat btwn ndognous and synthtic sourcs IZSPB Paglia Giuspp Biomdica Vtrinary Food Safty FOSA IN VIVO MRI TRACKING OF MESENCHYMAL STEM CELLS USED TO CLOSE POST SURGICAL BRONCHO PLEURAL FISTULAE: STUDIES IN AN EXPERIMENTAL ANIMAL MODEL I.E.O. Rizzo Stfania Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT Invstigating th Hippo pathway in brast cancr: idntification of novl biomarkrs and thraputic stratgis REGINA ELENA Maugri Saccà Marcllo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Amyotrophic Latral Sclrosis and Caffin Intak. An Italian Population Basd Cas Control Study MARIO NEGRI Pupillo Elisabtta Biomdica Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME Cognitiv rhabilitation aftr tmporal lob pilpsy surgry: outcoms and prdictors. CARLO BESTA Parnt Annalisa Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Th nural markrs of post strok rcovry: tracking th arly dynamics of cortical rorganization with a novl longitudinal multimodal approach. SANTA LUCIA Bonnì Sonia Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE 'KEEPING THE BODY IN MIND': MONITORING YOUNG PEOPLE WITH MENTAL DISORDERS BEING ADMINISTERED PSYCHOTROPIC DRUGS Abruzzo Giusti Laura Biomdica Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 113 di 356

114 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ATM HETEROZYGOSITY AS A MAJOR TUMOR SUSCEPTIBILITY FACTOR IN THE GENERAL POPULATION REGINA ELENA Prodosmo Andra Biomdica Oncology 1 Basic Tumor Cll Biology TCB Dvlopmnt of a nw diagnostic tool for arly diagnosis and prognosis of colorctal cancr Emilia Romagna BERTOLINI FEDERICA Biomdica Oncology 2 Cancr Biomarkrs DEVELOPMENT OF INNOVATIVE ANALYTICAL METHODS FOR MEAT PRODUCTS SAFETY AND QUALITY ASSURANCE IZSPB Iammarino Marco Biomdica Vtrinary Food Safty FOSA Prognostic Impact of Grmlin BRCA Mutations in Earlyonst Tripl ngativ Brast Cancr: A Multicntr, Population basd Cancr Rgistry Study Emilia Romagna Musolino Antonino Clinicoassistnzial Oncology 1 Basic Cancr Gntics CG Dvlopmnt and analysis of nw biomarkrs for th assssmnt of disas activity and tratmnt rspons in patints with chronic inflammatory bowl disass Toscana Faggioni Lornzo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Nw approachs to nhanc th immunognicity and fficacy of DNA and avipox basd rcombinant vaccins for th thrapy of HPV rlatd tumors Lombardia Bissa Massimiliano Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Nurological and biological aspcts of ocular surfac disass and thir impact on th quality of vision in rlation to occupational tasks and nvironmntal strss in th aging population NEUROLESI Rania Laura Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Emotional Procssing in Bipolar Disordr: an mbodid prspctiv study FATEBENEFRATELLI Bulgari Viola Biomdica Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Connct Our Childrn: Wb Halth Application for Monitoring Safty and Efficacy of Psychotropic Mdications in Childrn andadolscnts Sicilia Lambrti Marco Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 114 di 356

115 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Cartilag rgnration by Msnchymal Stm Clls (MSCs) culturd on a collagn scaffold (CCC) implantation and individual combind ffcts of a nutritional profil analogu to Mditrranan Dit, of TA 65, of rcombinant lubricin and of physical activit Sicilia Trovato Francsca Maria Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Innovativ us of satllit data for xposur assssmnt to valuat th halth ffcts of xtrm tmpraturs and air pollution in Rom Lazio Stafoggia Massimo Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Mitochondrial dysfunction in Progrssiv Supranuclar Palsy: possibl rol of mtal xposur MAGGIORE Viganò Maril Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nural Oxidativ Mtabolism and Dath NOMD BONE FRACTURE RISK IN GLUCOCORTICOID INDUCED OSTEOPOROSIS IN MYASTHENIA GRAVIS. A POSSIBLE ANABOLIC EFFECT OF PYRIDOSTIGMINE ON BONE TISSUE NEUROLESI Portaro Simona Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO Corrlation btwn Epilpsy and Small Vssl Disas: a translational study Calabria Scicchitano Francsca Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE HEAL2TOE: Towards a HEALthy locomotor dvlopmnt in idiopathic TOE walking, kinmatic and kintic analysis and dvlopmnt of a novl orthosis OSPEDALE BAMBINO GESU' TAVERNESE EMANUELA Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO Flxibl ndoscopic robotic dvic for paranasal diagnosis and tratmnt Toscana Dallan Iacopo Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD CSF B clls sorting: a nw approach in idntification of MS rlatd antigns. CARLO BESTA Duranti Fabio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 115 di 356

116 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Coronary artry disas progrssion in patints with acut coronary syndroms and diabts mllitus HUMANITAS Stfanini Giulio Giuspp Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Thrombolastomtry (TEM) in acut coagulopathy of trauma (ACT): dvlopmnt of an innovativ TEM drivn transfusion support protocol and sarch for nw prognostic markrs of ACT. SAN RAFFAELE MILANO Tassara Michla Giulia Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Molcular charactrization of glioblastoma multiform progrssion and rcurrnc: a nw in vivo modl for patints stratification and tratmnts tailoring Lombardia Giussani Carlo Giorgio Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT DIVERSITY MANAGEMENT STRATEGIES IMPACT ON WORK RELATED STRESS AND PATIENT SATISFACTION Emilia Romagna Rodschini Giulia Clinicoassistnzial Risk, Prvntion and Halth Bhavior Psychosocial Dvlopmnt, Risk, and Prvntion PDRP Mutimodal analysis in Fronto tmporal Dmntia SAN RAFFAELE PISANA MIRAGLIA FRANCESCA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Targtd gnom diting of th CD40LG gn for th tratmnt of X linkd hypr IgM immunodficincy SAN RAFFAELE MILANO Gnovs Pitro Biomdica Gns, Gnoms and Gntics Gn Thrapy and Inborn Errors GTIE Spcial Emphasis Panl Tsla MR invstigation of motor cortx in Amyotrophic Latral Sclrosis: functional and structural hallmarks for diagnosis and prognosis at a singl subjct lvl Toscana Psarsi Ilaria Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration ENVIRONMENTAL IMPACT ASSESSMENT ON TESTICULAR CANCER AND MALE REPRODUCTIVE FUNCTION PASCALE Crispo Anna Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 116 di 356

117 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Novl srological tsts for diagnosis and follow up of human cystic chinococcosis SAN MATTEO MARICONTI MARA Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Cardiac sympathtic nrvous systm: gntics, functional anatomy and risk of suddn dath. MAUGERI Novlli Valria Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Mitochondrial dysfunction as a common pathognic pathway in nurodgnration STELLA MARIS Mschini Maria Chiara Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Combination thrapy with Mirabgron and Tadalafil for th tratmnt of Nurognic Ovractiv Bladdr and Sxual Dysfunction in Multipl Sclrosis mal patints. Sicilia favilla vincnzo Clinicoassistnzial Digstiv, Kidny and Urological Systms Urologic and Kidny Dvlopmnt and Gnitourinary Disass UKGD Mditrranan Dit, Cllular Markrs of Low Grad Inflammation and Risk of Crbrovascular and Cardiovascular Evnts. NEUROMED Costanzo Simona Biomdica Population Scincs and Epidmiology Cardiovascular and Slp Epidmiology CASE Optimization and pilot clinical trial of a thrdimnsional lctromagntic ndovascular navigator Toscana Condino Sara Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Elctromagntic Dvics Spcial Emphasis Panl SEED CSF pptid profil in Mild Cognitiv Impairmnt with and with no AD pathology FATEBENEFRATELLI Marizzoni Moira Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nw stratgis for diagnostic, thraputic and clinical car in Mtabolism disordrs and cardiovascular disas Calabria Succurro Elna Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Molcular profil and pathway analysis of oropharyngal squamous cll carcinoma: an x vivo 3D multi layr cll cultur modl to idntify biomarkrs for patint tailord thrapis PASCALE Annunziata Clorinda Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 117 di 356

118 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A nw insight into pdiatric lukmia: Ch 1 involvmnt in oncognic c Myc signaling OSPEDALE BAMBINO GESU' Folgiro Valntina Biomdica Oncology 1 Basic Molcular Oncognsis MONC In vitro and in vivo studis for th application of Boron Nutron Captur Thrapy in patints affctd by malignant msothlioma SAN MATTEO Protti Nicoltta Biomdica Oncology 2 Radiation Thraputics and Biology RTB T lymphocyt rcruitmnt and svr chronic pilpsy: vidnc from human patints and xprimntal modl and possibl nuroprotctiv and antipilptic ffct of thrapis prvnting glia activation/nuroinflammation and T cll infiltration CARLO BESTA Finardi Adl Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Evaluation of gold nanoparticls as radionhancing agnt in th radiation thrapy tratmnt of gliobastoma multiform: an in vitro and in vivo study for a nw standard of car CARLO BESTA D Martin Elna Biomdica Oncology 2 Radiation Thraputics and Biology RTB MicroRNA as novl prognostic and pharmacognomic biomarkrs in prmatur infants with patnt ductus artriosus tratd with ibuprofn BURLO GAROFALO D Cunto Angla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Multimodal approach to th non invasiv monitoring of patints with disordrs of consciousnss Toscana Bandini Andra Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Th psychopathological and cognitiv pattrn of rar brain disass. CARLO BESTA Manfrdi Valntina Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Study of rprsntation and functional activity of CD4+ T cll substs in multipl myloma: association with disas status, prognosis and rspons to thrapy SAN RAFFAELE MILANO Di Lullo Giulia Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 118 di 356

119 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Effcts of nuromodulation (tdcs) for th tratmnt of Cocain Addiction. Rduction of Cortical mchanisms of Rward Bias and Intr Hmisphric unbalanc masurd by fnirs and EEG. FATEBENEFRATELLI Finocchiaro Robrta Clinicoassistnzial Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Modling human clonal dynamics of hmatopoitic systm rconstitution of gn thrapy patints through vctor intgration sits for prdicting systm rspons to clinical injuris SAN RAFFAELE MILANO Calabria Andra Biomdica Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD Targting bta Amyloid Pptid assmblis in Alzhimr Disas: a multidisciplinary approach (TAP MAD) FATEBENEFRATELLI Casalini Stfano Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Evaluation of innovativ molcular and protomic assays for rapid dtction of carbapnmas production among gram ngativ bactria dirctly from blood culturs SPALLANZANI Di Blla Stfano Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Glycosphingolipid synthtic pathway as valuabl thraputic option for th tratmnt of GOLPH3 dpndnt NSCLC. PASCALE Lon Alssandra Biomdica Oncology 1 Basic Molcular Oncognsis MONC Prdictiv rol of tumor hypoxia imaging, circulating micrornas and immun rlatd markrs in patints with locally advancd non small cll lung cancr (NSCLC). HUMANITAS Lopci Egsta Biomdica Oncology 2 Cancr Biomarkrs Cll autonomous and cll non autonomous rols of p27kip1 in HER2 drivn brast cancr onst and progrssion C.R.O. AVIANO Sgatto Ilnia Biomdica Oncology 1 Basic Molcular Oncognsis MONC Patints with oligomtastatic prostat cancr: rol of strotacic radiothrapy and xosoms. Possibl impact on cost/bnfits and clinical outcom Toscana Pasqualtti Francsco Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 119 di 356

120 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Lipostructur in brast rconstruction: comparativ analysis of th standard and four commrcially availabl Cll Assistd Lipotransfr tchniqus in trms of ability to nrich fat grafts in stm clls, clinical outcom and prvnt capsular contractur. Friuli Vnzia Giulia Lara Lazzaro Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS valuation and halth tchnology assssmnt of an innovativ approach to spinal fusion surgry: th patint spcific tmplats. Toscana Parchi Paolo Domnico Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT A protin profils study to idntify idal arly biomarkrs for High Risk Human Papillomaviruss infction and cancr progrssion diagnosis NEUROLESI Brtuccio Maria Paola Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Multimodal nurophysiological approach for th diagnostic and prognostic assssmnt of patints with disordrs of consciousnss Emilia Romagna Guaraldi Pitro Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Disclosing Crbral Cavrnous Malformations pathognsis: from gnotyp phnotyp corrlation to charactrization of cross talk in nurovascular unit NEUROLESI Scimon Conctta Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Th Biological Rsourc & Exprt Cntr of th IRCCS Scintific Institut of Romagna for th Study and Tratmnt of Cancr (BRC IRST): a hub and spok modl of biobank ntwork Istituto Scintifico Romagnolo Turri Valntina Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Magntic Rsonanc Spctroscopy as a markr of rspons to dopaminrgic tratmnt in Parkinson's Disas NEUROLESI CIURLEO ROSELLA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration VITAMIN E SUPPLEMENTATION FOR ANTIVIRAL TREATMENT OF CHRONIC HEPATITIS B. Emilia Romagna Conti Fabio Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 120 di 356

121 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Immobilization Systm Evaluation for Robot Patint Positioning Systm (RPPS) CROB Caivano Rocchina Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Th nuclar factor HMGA1: a novl gn for arly diagnosis and prognosis of typ 2 diabts mllitus Calabria IIRITANO STEFANIA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE CYCLING OF INTENSIFIED ANTIRTEROVIRALS IN PATIENTS WITH HIV INFECTION TREATED SINCE EARLY/ACUTE INFECTION (CYCLING Study) SPALLANZANI Pinntti Carmla Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Tsting th concpt of Acut Coronary Syndrom in Patints Without Angiographic Evidnc of Obstructiv Coronary Plaqus: A Cross Sctional Diagnostic Study SAN MATTEO LEONARDI SERGIO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS A Randomizd, Placbo controlld, Doubl Blind "Futility Dsign" Trial of R Tratmnt of Amyotrophic Latral Sclrosis. Emilia Romagna MANDRIOLI JESSICA Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Th nrvs PISTA projct: Nrvs Physiological Imaging for Saf Tratmnt Approach. Rol of combind ultrasonographic imaging and nurophysiological invstigation for tratmnt of priphral nrv pathologis. Sicilia Gagliardo Andra Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Small Businss Bionginring, Surgical Scincs, and Tchnology SBTS (SBIR/STTR) Monitoring and managing mtabolic disturbancs in popl taking antipsychotic drugs: a clustr randomizd trial of an intrvntion combining vidnc basd quality improvmnt and a computr basd intrvntion. Emilia Romagna Tdschini Enrico Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Mobil gntic lmnts: nw approachs for pidmiological studis on antibiotic rsistanc mchanisms in Gram ngativ clinical and nvironmntal isolats. Abruzzo Bllio Piranglo Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 121 di 356

122 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A MultidisciplinAry intrvntion of DOmiciliary assistanc for dmntd ldrly and thir cargivr: th ffcts on quality of lif and functional status Acronym: AMANDOSI I.N.R.C.A. Giuli Cinzia Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Combination of nzym rplacmnt thrapy and pharmacological chaprons for th tratmnt of Pomp disas. Campania Porto Catrina Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Mitochondrial disass in Tuscany: a stratgic plan to implmnt disas awarnss and managmnt STELLA MARIS Rubgni Anna Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration POST RESECTIONAL BRONCHO PLEURAL FISTULA CLOSURE BY AUTOLOGOUS BONE MARROW DERIVED MESENCHYMAL STEM CELL BRONCHOSCOPIC TRANSPLANTATION:AN EXPERIMENTAL MODEL ON GOATS I.E.O. Ptrlla Francsco Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Mningioma radiosurgry: hormonal rcptors modulation, rlatd pathways and thir corrlation with radiosnsitivity. In vitro and in vivo study. CARLO BESTA Pinzi Valntina Biomdica Oncology 2 Radiation Thraputics and Biology RTB Evaluation of th prothrombotic and inflammation stat in patints with svr aortic stnosis bfor and aftr implantation of two diffrnt prosthtic valvs: suturd vrsus suturlss bioprosthss. HUMANITAS Micli Antonio Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Trnd of HPV associatd oropharyngal cancr in Italy from 1990 to 2012 I. O. V. Baboci Lorna Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Th rol of Adnovirus 36 in th Obsity Istituto Suprior di Sanita' PONTERIO ELEONORA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 122 di 356

123 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Thalamo cortical dysfunction as a markr of Lwy Bodis Disas in th arly stag S.CAMILLO Dlli Pizzi Stfano Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt of a nw clinical valuation tool to chck spinal functions (STACMOQ STAbility Control and MOvmnt Quality) in nurological disass and aging basd on movmnt analysis DON GNOCCHI Pirali Catrina Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Unravlling th Gntic Dfcts in Progrssiv Familial Intrahpatic Cholstasis (PFIC): a Nxt Gnration Squncing Approach Emilia Romagna Vital Giovanni Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Tailord cathodal tdcs in drug rsistant pilptic patints OSPEDALE BAMBINO GESU' Assnza Giovanni Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Crizotinib Targtd Multistag Vctor for tratmnt of childhood malignant solid tumor (Nuroblastoma). Vnto Molinaro Robrto Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Rol of Nurgulin 1 signalling in th modulation of msncphalic dopaminrgic nurons activity: implications in th pathognsis and thrapy of schizophrnia SANTA LUCIA Ldonn Ada Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Th "Poli Framingham Study": a cohort study on cardiovascular risk, lifstyl and cognitiv function of midlif mploys of th Fondazion IRCCS Ca' Granda Ospdal Maggior Policlinico MAGGIORE Marcucci Maura Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvic for valuating laryngal cough rflx in halth subjcts and amyotrophic latral sclrosis (ALS) patints. MAGGIORE frasca vittorio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 123 di 356

124 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Bio Enginring in Proctological Surgry: autologous graft surgry. Toscana Giani Iacopo Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Muscl vibration and spasticity in strok: a combind nurophysiological and nuroradiological approach. NEUROLESI Naro Antonino Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP CD45RA dpltd donor lymphocyt infusions for th prvntion of infctions in patints affctd by hmatological malignancis aftr haploidntical stm cll transplantation and post transplant cyclophosphamid HUMANITAS CROCCHIOLO ROBERTO Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Th quilibrium in th frontal plan during stanc and locomotion along curvd trajctoris: basic mchanisms, rational for rhabilitation and validation of training protocols in patints with slctd disass of th cntral nrvous systm. MAUGERI Godi Marco Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration In vitro and in vivo modls to study antitransglutaminas antibodis dpndnt rproductiv changs BURLO GAROFALO Quaglia Sara Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Exploring brain ntworks and structural connctivity architctur as nural corrlat of cognitiv rcovry aftr strok MONDINO Zucchlla Chiara Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG A synuclin dposition, cross modal cortical plasticity and motor symptoms dtctd by whol body biosnsors in Parkinson's Disas: a nw translational approach NEUROMED Suppa Antonio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Brath Biomarkrs and Acut rspiratory distrss Syndrom Puglia Mirablla Lucia Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Analysis of toxicity of anti angiognic thrapy in ldrly subjcts and in vitro modls of ndothlial clls aging. ARCISPEDALE Chiapplli Martina Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 124 di 356

125 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv PSY Sport Rhab: Invstigation of th rol of Physical Activity and Psycho ducation on immun function and quality of lif in cancr survivors ONCOLOGICO DI BARI Romito Francsca Clinicoassistnzial Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Chimric antign rcptor rdirctd T clls targting CD19 antign: first in human Italian trial for childrn with chmothrapy rfractory Acut Lymphoblastic Lukmia. OSPEDALE BAMBINO GESU' Quintarlli Conctta Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII FOXO3a FOXM1 axis in pdiatric T cll acut lymphoblastic lukmia (T ALL): involvmnt in tumor progrssion, pigntic rprogramming and drug rsistanc. Vnto Bortolozzi Robrta Biomdica Intrdisciplinary Molcular Scincs and Training Fllowship: Oncological Scincs F Innovativ stratgis to boost thymopoisis aftr cytoablativ and immunosupprssiv tratmnt SAN RAFFAELE MILANO BORTOLOMA ILEANA Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Familial Prion Polynuropathy (FPP): Prvalnc Of Prion Protin Mutation In Polynuropathy Mimicking Familial Amyloid Polynuropathy in Emilia Romagna Rgion Emilia Romagna D'Anglo Robrto Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Gntic pidmiology and molcular charactrization of phnotyps associatd with D4Z4 macrosatllit rpat variations: novl diagnostic tools for myopathis. Toscana Ricci Giulia Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Noninvasiv assssmnt of spln stiffnss by shar wav lastography in cirrhotic patints as prdictiv sign of portal hyprtnsion and sophagal varics SAN MATTEO Lissandrin Raffalla Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Risk assssmnt of Criman Congo hmorrhagic fvr in North East Italy IZSVE Mughini Gras Lapo Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 125 di 356

126 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Functional Magntic Rsonanc Imaging and olfactory rcptors gn variants in th valuation of smll prcption in svr obs patints. SDN Labruna Giuspp Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Th rol of th cortical xcitability in th modulation of nuroplasticity in nurological disass FATEBENEFRATELLI Frtonani Anna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nuroimaging corrlats of blinking abnormalitis in patints with Progrssiv Supranuclar Palsy. NEUROMED Bologna Matto Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Molcular mchanisms undrling oxidativ strss in CDKL5 disordrs Toscana Pcorlli Alssandra Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Nw stratgis for targtd thraputic intrvntion of obsity: xploiting fat "browning" by Minralocorticoid Rcptor and p66shc intraction SAN RAFFAELE PISANA Marzolla Vincnzo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Th PRIORITY Study PRdictIng long trm Outcoms aftr Isolatd coronary artry bypass surgry Pimont BARILI FABIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Kinmatic and lctromyographic assistd ankl spasticity tratmnt. Comparativ study to addrss tratmnt fficacy. SANTA LUCIA Tamburlla Fdrica Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Snsory, Motor and Cognitiv Nuroscinc Fllowship F02B Anticoagulation thrapy with warfarin in th urmic patints: traditional and nw markrs of vascular calcification Emilia Romagna salomon luisa Clinicoassistnzial Vascular and Hmatology Hmostasis and Thrombosis HT Nw tchnological approachs for th improvmnt of th safty and quality of Italian fishry products (SAFEfish) IZSPLV Bianchi Danila Manila Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 126 di 356

127 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Assssmnt of tumor htrognity of colorctal carcinoma through analysis of liquid biopsis PASCALE Rachiglio Anna Maria Biomdica Oncology 2 Cancr Biomarkrs SLEEP DISORDERED BREATHING AND CARDIAC SYMPATHETIC INNERVATION IN PATIENTS AFFECTED BY HEART FAILURE: PATHOPHYSIOLOGICAL MECHANISMS, PREVALENCE AND PROGNOSTIC IMPLICATIONS. SDN Marciano Catrina Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Dciphring th mchanisms of rsistanc to lapatinib in brast cancr Campania Giuliano Mario Biomdica Oncology 1 Basic Tumor Cll Biology TCB Prioprativ Administration of Dxamthason and Infction SAN RAFFAELE MILANO Zambon Massimo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Slf awarnss in prclinical Alzhimr s Disas: nural corrlats and prognostic implications Emilia Romagna Tondlli Manula Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Th link btwn HER2 addiction and immun infiltration as dtrminant of trastuzumab fficacy ISTITUTO TUMORI MILANO Triulzi Tiziana Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Childhood Cancr Rgistry of Puglia ONCOLOGICO DI BARI CANNONE GRAZIA Clinicoassistnzial ANTONELLA Population Scincs and Epidmiology Epidmiology of Cancr EPIC SPRINT a post Strok inpatint Rhabilitation in a INtllignt nvironmnt I.N.R.C.A. Flici Elisa Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Snsory, Motor and Cognitiv Nuroscinc Fllowship F02B Mthyln blu in patints with sptic shock. A multicntr randomizd clinical trial. SAN RAFFAELE MILANO Pasin Laura Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 127 di 356

128 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv HOXB7 mastr rol in th molcular circuitry associatd with acquird rsistanc to anti strogn tratmnts in human brast cancr: potntial prdictiv and thraputic valus Istituto Suprior di Sanita' Errico Maria Cristina Biomdica Oncology 1 Basic Tumor Cll Biology TCB End Of Lif Car Pathways In Gnral Hospitals Emilia Romagna Carandina Ilaria Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD TIME RELIABILITY OF LASER'S DEVICES IN DERMATOLOGY SAN GALLICANO Mariano Maria Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO TOWARD ADAPTIVE DEEP BRAIN STIMULATION FOR GAIT DISTURBANCES IN PARKINSON'S DISEASE. MAGGIORE Rosa Manula Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Us of attnuatd Salmonlla ntrica srovar Typhimurium as anticancr tratmnt Istituto Suprior di Sanita' Chirullo Barbara Biomdica Oncology 2 Dvlopmntal Thraputics DT Rol of th mlanoma stm clls tumor micronvironmnt intrplay in mlanoma invasion and mtastasis ARCISPEDALE Dallaglio Katiuscia Biomdica Oncology 1 Basic Tumor Micronvironmnt TME NEUROPILIN 1, PLACENTA GROWTH FACTOR AND PLATELET DERIVED GROWTH FACTOR C AS THERAPEUTIC TARGETS IN HUMAN MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Ruffini Fdrica Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Th prdictiv valus of brain connctivity for th diagnosis of disordr of consciousnss using a multimodal magntic rsonanc imaging protocol NEUROLESI Marino Silvia Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE mir 155 as an pigntic rgulator of B cll linag activity in Rhumatoid Arthritis Lazio Alivrnini Stfano Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 128 di 356

129 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Augmntd Rality in Had and Nck Oncology: dvlopmnt of a systm to improv surgical rsction, rconstruction and intrdisciplinary intrfac btwn surgry, pathology and radiothrapy. CASA SOLLIEVO SOFFERENZA Coplli Chiara Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS NON INVASIVE "IN VIVO" DIAGNOSIS AND THERAPEUTICAL FOLLOW UP OF CICATRICIAL AND NON CICATRICIAL ALOPECIAS SAN GALLICANO AGOZZINO MARINA Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Inflammasom activity and modulation in diffrnt Multipl Sclrosis forms and as a prdictor of rspons to intrfron bta thrapy Emilia Romagna Frraro Diana Biomdica Immunology Innat Immunity And Inflammation III Familial Hyprcholstrolmia: study of mirnom and protom to idntify nw molcular pathways SDN Di Taranto Maria Donata Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Enhancd survillanc and clinical impact of hospitalacquird viral gastrontritis in childrn hospitals OSPEDALE BAMBINO GESU' Valntini Diltta Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Exploring Gntic Connctions of Dysrgulatd Insulin Scrtion Btwn Congnital Hyprinsulinism and Insulinomas for th Idntification of Nw Causativ Gns BURLO GAROFALO ATHANASAKI EMMANOUIL Biomdica Gns, Gnoms and S Gntics Gntics of Halth and Disas GHD Rsting stat ntworks and cognitiv functioning in pilptic patints NEUROLESI Nunnari Domnica Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Sntinl lymph nod biopsy in brast cancr: Impact of biological tumor faturs on lymphatic drainag pattrn and on th choic of th lymphoscintigraphy xcution modality. ARCISPEDALE falco giuspp Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training Fllowship: Oncological Scincs F STEM CELLS DERIVED FROM EXTRA EMBRYONIC TISSUES FOR TENDON REGENERATION Abruzzo Abat Michl Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 129 di 356

130 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Targting th lysosom to modulat mtorc1 function and trat obsity associatd mtabolic disordrs SAN RAFFAELE MILANO sttmbr Carmin Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Transcathtr artrial chmombolization using Fotmustin Mixd with Dgradabl Starch Microsphrs (DMS) plus intravnous ipilimumab for Livr Mtastass from uval mlanoma REGINA ELENA nuzzo carmn Biomdica Oncology 2 Oncology CONC Biomchanical study of th postural balanc: sarch for rliabl biomarkrs to dvlop a micro lctromachinal dvic basd on haptic fdback as a systm to prvnt falls SDN Agosti Valria Biomdica Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Nw tratmnt prspctivs in Eating Disordrs: th fficacy of non invasiv brain dirctd tratmnt OSPEDALE BAMBINO GESU' Costanzo Floriana Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Survillanc of Mycobactrium Avium subspcis Paratubrculosis infction through th analysis of microbiom and nvironmntal factors. IZSSI FALDUTO MARIA Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Idntification of lukamia cll ligands for activating human NK rcptors OSPEDALE BAMBINO GESU' Romania Paolo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Us of arly non invasiv vntilation to rduc th nd for intnsiv car unit. A multricntric randomizd trial. SAN RAFFAELE MILANO Monti Giacomo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Sorting out Wst Nil virus Pandora's box: idntifying virulnc dtrminants to undrstand host anti viral immun rsponss and prdict pathognsis Istituto Suprior di Sanita' Capocfalo Antonio Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 130 di 356

131 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Multisnsory intgration and immun systm: nw prspctivs for obsity. AUXOLOGICO Scarpina Fdrica Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Nurondocrinology, Nuroimmunology and Bhavior NNB MODELING REDOX BALANCE IN HEPATIC PROGENITOR CELLS: IMPACT ON CARCINOGENESIS DURING CHRONIC LIVER DISEASES Puglia Bllanti Francsco Biomdica Oncology 1 Basic Cancr Etiology CE Study of microrna signaturs and functions in frontotmporal dmntia FATEBENEFRATELLI Maffioltti Elisabtta Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Connctivity changs as biomarkr of nurodgnration in Alzhimr's disas and frontotmporal dmntia: a multimodal nuroimaging approach. SDN Rombtto Sara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration pharmacogntic bass of th safty and fficacy of novl adjuvants in vaccins: a mthodological approach SAN RAFFAELE MILANO Rigamonti Elna Biomdica Immunology Vaccins Against Microbial Disass VMD Umbria Fram work for Anticoagulation Survillanc: long trm safty and ffctivnss of nw oral anticoagulants in ral lif for prvntion of cardiombolism in non valvular atrial fibrillation and for th tratmnt of vnous thrombombolism. Th UFAS s Umbria Vdovati Maria Cristina Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Charactrization of microrna (MiRNAs) altrations in nuronal lik modls of nurodgnrativ disordrs SANTA LUCIA Croc Nicoltta Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Th nural undrpinnings of motional impulsivity as a common biomarkr of affctiv disordrs: an intgratd multimodal imaging study. MEDEA Maggioni Elonora Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Thyroid cancr risk and gn suscptibility in Mt. Etna volcanic ara: a cas control study. Sicilia Malandrino Pasqualino Clinicoassistnzial Oncology 1 Basic Cancr Etiology CE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 131 di 356

132 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Targtd prsonalizd thrapy of Acut Myloid Lukmia: Nxt Gnration Squncing and mtabolomics basd approachs Emilia Romagna papayannids cristina Biomdica Oncology 1 Basic Cancr Gntics CG Th rol of cytomgalovirus and sphingosin 1 phosphat cross talk on stmnss and aggrssivnss of glioblastoma multiform: an intgratd molcular and bioinformatic approach to driv molcular mchanisms and thraputic implications MAGGIORE marfia giovanni Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP A novl in vivo hydroxyapatit functionalizd scaffold (SCID synth bon) as a prclinical platform for anti Myloma agnts dvlopmnt Calabria Calimri Trsa Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Q fvr in Italy: an intgratd survillanc systm basd on pidmiological and gnotyping studis in human and animal populations Emilia Romagna Pirro Anna Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Olfactory dysfunction in Multipl Sclrosis dtctd by using Olfactory Evnt Rlatd Potntials: arly markr of nuroinflammation nurodgnration or disas progrssion? NEUROLESI Caminiti Fabrizia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Adrnomdullin and autoimmun hpatitis: nw insight in thymic mchanisms Vnto D Martin Sara Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Long trm Rcrational football training as usful tool to improv halth rlatd fitnss in T2DM subjcts : ffcts on muscl oxidativ mtabolism, CVD risk, QoL and pharmacological tratmnt. SDN Marton Domnico Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Idntification of potntial glioblastoma associatd autoantibodis: dfinition of nw circulating biomarkrs and dvlopmnt of anti angiognic multitargt thrapis MAGGIORE navon stfania Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 132 di 356

133 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A randomizd control trial pilot study on ffctivnss of a combination Btwn assistiv tchnology, nurostimulation and bhavioural stratgy in in prsons with Disordrs Of consciousnss: BUILD ON projct S.CAMILLO Cavinato Marianna Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE STEREOTACTIC HYPOFRACTIONATED RADIOTHERAPY (SBRT) WITH CYBERKNIFE SYSTEM FOR LOW INTERMEDIATE RISK PROSTATE CANCER PASCALE Borzillo Valntina Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Dvlopmnt of a statistical procdur to facilitat th us of circulating microrna biomarkrs in clinical practic by adjusting th classification accuracy to plasma hamolysis lvls ISTITUTO TUMORI MILANO Pizzamiglio Sara Biomdica Oncology 2 Cancr Biomarkrs Liquid biopsis for monitoring th activity of anti EGFR thrapis in mtastatic colorctal carcinoma patints with livr limitd disas PASCALE Ottaiano Alssandro Clinicoassistnzial Oncology 2 Cancr Biomarkrs Discovry of prognostic vs. prdictiv biomarkrs in patints with advancd, BRAF mutatd colorctal cancr rciving standard chmothrapy vs. targtd tratmnt ISTITUTO TUMORI MILANO Pitrantonio Filippo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Biormdiation as a novl tool for fd and food safty. IZSLER Lornzi Valntina Biomdica Vtrinary Food Safty FOSA Assssing immun rsponss against th viral nuraminidas to improv influnza vaccin fficacy. Istituto Suprior di Sanita' Di Martino Angla Biomdica Immunology Vaccins Against Microbial Disass VMD Autophagy impairmnt in patints with chronic HCV infction: impact on statohpatitis and carcinognsis. SPALLANZANI Vscovo Tiziana Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB COGNITIVE NEUROGENETICS OF DEVELOPMENTAL DYSLEXIA: FROM GENES TO REHABILITATION MEDEA Maschrtti Sara Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 133 di 356

134 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Immunomodulation in Multipl Sclrosis: Estogn rcptor alpha rol. From th bnch to th bdsid. Pimont Clrico Marinlla Biomdica Immunology Cllular and Molcular Immunology A CMIA Charactrization of th rol of SIRT dpndnt dactylation of C/EBP alpha in th pathognsis of FLT3 ITD+ lukmia ARCISPEDALE Fragliasso Valntina Biomdica Oncology 1 Basic Molcular Oncognsis MONC NON INVASIVE BRAIN STIMULATION AS ADJUVANT THERAPY FOR DEMENTIA MAGGIORE Mamli Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Th long trm impact of svr acquird brain injury (sabi) on coping stratgis and quality of lif of patints and cargivrs: nw intrvntion stratgis NEUROLESI Corallo Francsco Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Dvlopmnt and validation of prdictiv modls basd on clinical, dosimtric and skin spctrophotomtry data for objctiv slction of brast cancr patints for tratmnt with intnsity modulatd radiation thrapy ISTITUTO TUMORI MILANO Carrara Mauro Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Combining constraint inducd movmnt thrapy and BCI drivn functional lctrical stimulation for snsorimotor nuromodulation: nhancing arm functional rcovry SANTA LUCIA Moron Giovanni Biomdica Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Usfulnss of Diffusion Wightd Magntic Rsonanc Imaging in th charactrization of utrin malformations. Abruzzo Maccaron Marica Tina Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Rproductiv Scincs Small Businss SEP EMNR E11 B Dit,microbiota, intstinal barrir function and cancr: nw insight for novl thraputic approachs HUMANITAS VETRANO STEFANIA Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 134 di 356

135 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Mycoplasma pnumonia post infctious ncphalitis in childrn: a modl to study th rol of infctions in th dvlopmnt of autoimmunity DON GNOCCHI Nociti Viviana Biomdica Immunology Immunity and Host Dfns IHD OPIOID ANTAGONISM AND DOPAMINERGIC SYSTEM IN GAMBLING DISORDER: GENETIC, NEUROIMAGING AND CLINICAL CORRELATES Lazio Di Nicola Marco Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Extnsiv molcular charactrization of a larg sris of bnign and malignant msothlial plural lsions Toscana Proitti Agns Biomdica Oncology 2 Cancr Biomarkrs Cohsins: from Cornlia d Lang Syndrom to lukmia Lombardia Maitz Silvia Batric Biomdica Oncology 1 Basic Cancr Gntics CG MIBI scan and molcular markrs for a nw multidisciplinary diagnostic approach in th managmnt of hypofunctioning thyroid Thy 3 noduls Pimont CALANDRI ENRICO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Th Effct of Intrapartum Synthtic Oxytocin and Oxytocin Rcptor Polymorphisms on Infant Bhavior. STELLA MARIS Prisco Hannah Margarta Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD CB1 rcptor and Kv7 potassium channls: novl molcular targts for th tratmnt of Duchnn Muscular Dystrophy (DMD) Molis Ambrosino Paolo Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Dvlopmnt and Disas SBDD Biological charactrization of follicular lymphoma to improv diagnosis and tratmnt modalitis: a rsarch proposal from a phas III clinical trial (FIL RENOIR12) Provincia autonoma Bolzano Michal Mian Biomdica Oncology 2 Cancr Biomarkrs Exploring novl molcular targts for th tratmnt of nurodgnrativ disass FATEBENEFRATELLI Russo Isablla Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 135 di 356

136 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Analysis of mutational frquncy of th gns involvd in non syndromic haring loss, study of GJB2 promotr mthylation, gnotyp phnotyp corrlation, stablishmnt of a gntic audiological algorithm for arly diagnosis and managmnt of patints wit Sicilia amorini maria Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Cost analysis of managmnt of ldrly Parkinson's disas patints in Italy; bnfits in trm of quality of lif and halthcar costs of an ICT modl of trtiary prvntion of cognitiv dclin and motor function through training of th cognitiv functio SAN RAFFAELE PISANA LIZIO ROBERTA Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Imag basd high prcision hypofractionatd Intnsity Modulation Radiation Thrapy and concurrnt Tmozolomid in patints affctd by Glioblastoma ARCISPEDALE Ciammlla Patrizia Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Complx nds and Transition from Pdiatric to Adult Car in Patints Affctd by Nurological Conditions CARLO BESTA Cavallra Vanssa Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD A nw stratgy for th dtction of rsidual lukmia clls Vnto Paganin Maddalna Biomdica Oncology 2 Cancr Biomarkrs Protctiv ffcts of cognitiv rsrv in glioma patints: Nuropsychological and psychosocial invstigations Friuli Vnzia Giulia Campanlla Fabio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Invstigation on th functional outcoms of prlingually daf childrn: diffrncs btwn monaural and binaural haring OSPEDALE BAMBINO GESU' Giannantonio Sara Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Auditory Systm AUD Magntic and lctric transcranial brain stimulation for nuro rhabilitation purposs: from patho physiological concpts to novl tratmnt stratgis Lazio Frrri Florinda Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 136 di 356

137 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt of rapid tsts for zoonotic Babsia spcis diagnosis and molcular charactrization of strains in ordr to find nw control stratgis IZSSI Blanda Valria Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Non paralytic botulinum molcul for th control of migrain pain MONDINO Mangion Antonina Biomdica Brain Disordrs and Stfania Nuroscinc Nuroscinc and Nurodgnration Cognitiv and bhaviuoral outcom and corrlation with MRI findings in childrn with disordrs of crbllar growth and dvlopmnt, in particular postrior fossa malformations or arly ftal crbllar injury du to prtrm birth. CARLO BESTA Bulghroni Sara Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Gnomics of triglycrid pathways and dismtabolic, rnal, andcardiovascular complications. A nw prsonal gnomics approach to an oldproblm. Vnto Martinlli Nicola Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Th drailmnts of th visuo attntional and motor dvlopmnt trajctoris as arly markrs for autism spctrum disordr MEDEA Luca Ronconi Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Inhibition of contralsional crbral motor cortx, through non invasiv brain stimulation and constraint inducd thrapy, in arly subacut strok patints DON GNOCCHI Di Sipio Enrica Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Intnsification of antirtroviral thrapy with cycls of dfripron to rduc th amount of total HIV DNA in priphral blood in HIV infctd patints on antirtroviral thrapy, with undtctabl HIV RNA by ral tim PCR (kpcr) Lombardia Cossu Maria Vittoria Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Th us of minimally invasiv surgry vido systms: 3D vs 2D. Lazio Giordano Valria Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 137 di 356

138 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Us of Oliv Oil Polyphnols to prvnt Pritonal Dialysis Tchniqu Failur by Rducing Pritonum Fibrosis Calabria Vizza Donatlla Biomdica Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU Using Positron Emission Tomography with Florbtapir F18 for dtction of cortical amyloid in Alzhimr's Disas: nuropsychological and crbral mtabolic prdictors in patints rciving cognitiv rhabilitation. SANTA LUCIA Di Iulio Fulvia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Building prdiction modls of accumulation of long trm disability and cognitiv impairmnt in patints with multipl sclrosis intgrating structural and functional MRI masurs across disas clinical phnotyp: prospctiv studis of adult and pdiatri CASA SOLLIEVO SOFFERENZA Coptti Massimiliano Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dissction analysis of th whit mattr anatomy in normal childrn's brain OSPEDALE BAMBINO GESU' D Bndictis Alssandro Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Evaluation of in vivo and x vivo biomarkrs for th prdiction of chmothrapy rspons incastration rsistant mtastatic prostat cancr patints: 18F Fluorocholin PET/CT imagingand circulating tumor clls analysis MAUGERI SPINAPOLICE ELENA GIULIA Biomdica Oncology 2 Cancr Biomarkrs ICF as a framwork for a nw Italian multidisciplinary approach for padiatric rhumatic rhabilitation: a randomisd controlld trial Emilia Romagna Salghtti Annamaria Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Lgionllosis and Tourism. A Modl of Risk Analysis for cruis ships and lins NEUROLESI Mlcarn Lucia Clinicoassistnzial Infctious Disass and Microbiology Bactrial Pathognsis BACP DYSLEXIA PREVENTION THROUGH NEUROCOGNITIVE VIDEOGAMES MEDEA Gori Simon Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 138 di 356

139 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Duodnum: a ky playr in th rgulation of glucos mtabolism Campania Muscogiuri Giovanna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F A HUMAN PROTEOME PROJECT INITIATIVE TO UNVEIL BIOCHEMICAL,PROTEOMIC AND METABONOMIC VARIATIONS IN CYBRID CELL LINES CARRYING m.13513g>a MUTATION IN ND5 GENE, ASSOCIATED TO DIFFERENT CLINICAL PHENOTYPES. OSPEDALE BAMBINO GESU' Torraco Alssandra Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nural Oxidativ Mtabolism and Dath NOMD Crosstalk btwn adipocyts and brast cancr clls in obsity Campania D'Esposito Vittoria Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Exosomal RNA profiling for ALS arly diagnosis Istituto Suprior di Sanita' VINCI RAMONA Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Epidmiology of Anisakiasis in Italy: a multidisciplinary approach to study th host parasit intraction, humans Anisakis in ordr to lucidat clinical faturs and diagnostic aspcts of Anisakis allrgy disas. IZSSI Mazzucco Waltr Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP Functional communications ntwork of MiRNAs in High Grad Glioma PASCALE d Antonllis Pasqualino Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM An intgratd and intnsiv tratmnt in patints with Mild Cognitiv Impairmnt for prsrving cognition and rducing convrsion to dmntia FATEBENEFRATELLI Brignani Dbora Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 139 di 356

140 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Motor rhabilitation trials in Parkinson Disas: Gait Analysis as objctiv masur of clinical improvmnt SANTA LUCIA Marchtti fabio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration From Frontotmporal Lobar Dgnration to Pagt Disas of Bon: idntifying common pathognic pathways using intgratd gntic and clinical approachs Pimont Rubino Elisa Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Doxycyclin Thrapy aftr Endovascular Anurysm Rpair in th Prsnc of Typ II Endolak Emilia Romagna gallitto nrico Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Protolytic ffct of matrix mtalloprotinass on antitumor ncrosis factor (TNF) alpha antibodis: possibl corrlation with rspons to anti TNF alpha tratmnt in patints with inflammatory bowl disas SAN MATTEO Bianchri Paolo Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB High frquncy bilatral rptitiv trascranial magntic stimulation with H coin ovr th lft and right broca s aras to improv languag function in chronic non flunt post strok aphasic patint. SAN RAFFAELE MILANO Chiffo Raffalla Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Rdfining Rcurrnt Unipolar Dprssion by a nuroscinc basd approach. SANTA LUCIA Mazzarini Lornzo Clinicoassistnzial Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS A novl assssmnt of dvlopmnt of autonomous nrvous systm in growth rstrictd ftuss BURLO GAROFALO Stampalija Tamara Clinicoassistnzial Biology of Dvlopmnt and Aging Dvlopmnt 1 DEV Analysis of immun rspons inducd by M.bovis in naturally infctd pigs: pathogntic, pidmiological and public halth valuations IZSSI Amato Bndtta Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 140 di 356

141 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Inhibiting ffct of a fungal polysaccharid on prolifration of mlanoma clls SAN GALLICANO Scarpari Marzia Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS VIPP projct (Vaccination in Immunocompromisd Pdiatric Population).Analysis of dvlopmnt and prsistnc of protctiv immunity aftr nw and routin vaccinations in immunocompromisd pdiatric population. OSPEDALE BAMBINO GESU' Palma Paolo Biomdica Immunology Immunity and Host Dfns IHD MRI and biological markrs of nurodgnration in multipl sclrosis DON GNOCCHI Brgsland Nils Ptr Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Evaluation of th piduroscopy ffctivnss in patints with chronic low back pain: th rol of inflammation as a pathognic mchanism of pain Provincia autonoma Trnto Violini Alssia Clinicoassistnzial Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Ex vivo activity valuation of Th17 and invariant NKT clls from malignant plural msothlioma patints on standard chmothrapy protocols : prognostic impact to dvlopmnt nw biomarkrs, bttr rspons to chmothrapy and prolongd survival with fw Pimont altomar manula Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Immunothraputic intrvntions to ovrcom tumor micronvironmnt rlatd scap mchanisms in Adoptiv Cllular Thrapy approachs for CD30+ lymphoma OSPEDALE BAMBINO GESU' DE ANGELIS BIAGIO Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Evaluation of wild and captiv dolphin wlfar in a program of dolphin watching for patints affctd by mntal illnss. Amniotic stm clls drivd vsicls: thir rol as mdiators of ndomtrial rgnration. IZSPLV diana grta Biomdica Vtrinary Animal wlfar ANWE March Corradtti Alssandra Biomdica Cll Biology Intrcllular Intractions ICI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 141 di 356

142 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exploring pathogntic mchanisms of gntic inflammation rlatd pilpsis: human and animal studis. OSPEDALE BAMBINO GESU' Spcchio Nicola Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Biomarkrs for nw thraputic stratgis in Alzhimr's Disas: nuroimaging studis Sicilia Patrniti Irn Clinicoassistnzial Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN QoLITch: A mthodological framwork and toolkit to valuat th Quality of Lif Improvmnt with nw Tchnologis in th aging population with nurological and cardiovascular disass for th mpowrmnt of th halth car srvics. I.N.R.C.A. Bvilacqua Robrta Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Molcular bass in strok rhabilitation: an pignomic study DON GNOCCHI Di Lornzo Chrubino Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA IDENTIFICATION AND CHARACTERIZATION OF GENES/PATHWAYS PROGNOSTIC OF HIGH RISK OF RELAPSE METASTASES IN BREAST AND COLORECTAL RESIDUAL TUMORS FOLLOWING NEOADJUVANT THERAPY Lazio milano annalisa Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Prioprativ lvosimndan in high risk patints undrgoing non cardiac surgry. A multicntr randomizd trial. SAN RAFFAELE MILANO Lmbo Rosalba Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Dvlopmnt and valuation of hands on tools for th control of foodborn pathogns in lafy vgtabls IZSPLV Bllio Albrto Biomdica Vtrinary Food Safty FOSA Ulysss on th whlchair: nostalgia as comforting tool SANTA LUCIA Bllo Annalisa Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Assssmnt of tumor hypoxia in patints with crvical cancr: impact of 18F FAZA PET/CT on prsonalizd tratmnt SAN RAFFAELE MILANO MAPELLI PAOLA Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 142 di 356

143 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv AhR rol in thyroid malignancis I. O. V. Barollo Susi Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F Evidnc basd pathways of car for chronic disass: socioconomic diffrncs in accss and halth outcoms Lazio Blludi Valria Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Prostaglandin D2 synthas (PTGDS) and mylin dgnration in priphral nrvous systm: idntification of nw signal pathways to trat chronic complications of Diabts SAN RAFFAELE MILANO TRIMARCO AMELIA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Longitudinal volution and clinical impact of nurodgnration and mylin loss and rpair in arly rlapsing rmitting and primary progrssiv Multipl Sclrosis NEUROLESI Battaglini Marco Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration INDICATION: INtllctual Disability Imaging ChAractrizaTION MEDEA Pruzzo Dnis Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD TARGETING THE PI3K/mTOR NETWORK TO IDENTIFY NEW POTENTIAL DRUGS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA BURLO GAROFALO Simioni Carolina Biomdica Oncology 1 Basic Tumor Cll Biology TCB Community Car 2.0 NEUROLESI Carilli Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Quality of lif in oral cancr survivors: a protocol for assssmnt and managmnt. Sicilia Di Fd Vronica Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 143 di 356

144 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv hydroxylglutarat (2HG) and isocitrat dhydrognas (IDH1/2) mutations as molcular markrs and targtdimmunothrapy in gliomas. CARLO BESTA Anghilri Elna Biomdica Oncology 2 Cancr Biomarkrs How to choos virtual rality protocol: motivation, attntion and physiological changs in diffrnt intractiv nvironmnts DON GNOCCHI alviti fdrica Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT HEPATITIS E VIRUS: AN EMERGING INFECTIOUS DISEASE IN ITALY. MOLECULAR DETECTION AND CHARACTERIZATION OF ISOLATES BY THE NOVEL NEXT GENERATION SEQUENCING TECHNOLOGY Istituto Suprior di Sanita' Taffon Stfania Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F NODAL AND PARANODAL COMPONENTS AS AUTOIMMUNE TARGETS IN INFLAMMATORY DEMYELINATING DISORDERS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM MONDINO Corts Andra Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun Rol of Thymic stromal lymphopoitin on immun cll polarisation and cancr dvlopmnt I.E.O. Fornasa Giulia Clinicoassistnzial Immunology Immunology Fllowships and Ara F T cll mdiatd snscnc induction: an unrvald rol for CD8+ lymphocyts in multipl sclrosis? SANTA LUCIA Di Mitri Diltta Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Construction of gnomic libraris of Mycobactrium Bovis for th idntification of nw antignsas vaccin candidats IZSSI Mandanici Francsca Biomdica Immunology Vaccins Against Microbial Disass VMD EVALUATION OF THE APPROPRIATENESS OF PRESCRIPTION AND INTERACTION OF MEDICATIONS IN ELDERLY PATIENTS WITH MULTIPLE DISEASE Campania Trimarco Valntina Biomdica Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Mild cognitiv impairmnt and saf driving ability: valuation with motion analysis in virtual rality. DON GNOCCHI Imbimbo Isablla Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 144 di 356

145 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv DECIPHERING ETIOLOGY FOR APPROPRIATE CLINICAL CARE : INVESTIGATING MICROCEPHALY NEURODEVELOPMENTAL IMPAIRMENT SKELETAL ANOMALIES IN PEDIATRIC AGE MAGGIORE Milani Donatlla Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Physical xrcis for prvntion of dmntia: a randomizd, paralll group, obsrvr blindd clinical trial Molis Cristofano Adriana Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Noninvasiv brain stimulation (NIBS) in patints with Charcot Mari Tooth disas. Strngthning th larning of functional stratgis. DON GNOCCHI Paolasso Ilaria Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT Cu Cl2 in prostat cancr for diagnostic dtction of lymph nod and bon mtastass and for mtabolic radiothrapy I. O. V. NEGRI ANNA Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB INCIDENCE AND PROGNOSTIC VALUE OF DIAPHRAGM DYSFUNCTION EVALUATED WITH TRANS THORACIC ULTRASOUND IN ACUTE RESPIRATORY FAILURE SECONDARY TO ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Emilia Romagna Antnora Fdrico Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR NET Thalidomid, a novl immunological tratmnt to modify th natural history of padiatric Crohn's disas: a nw proposal from a wll stablishd padiatric rsarch ntwork. BURLO GAROFALO Vntura Alssandro Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG NET Gntic and immunological study of childrn with Crohn's disas rciving thalidomid tratmnt Lombardia Badolato Raffal Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG NET Evaluation of th ffct of pharmacokintic, mtabolomic and pharmacognomic, profils of thalidomid on rspons and toxicity in childrn with Crohn's disas C.R.O. AVIANO Toffoli Giuspp Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 145 di 356

146 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Nw mrging tchnologis and thir translational application to gnomic mdicin: gntic laboratoris automation, from Sangr squncing to targtd NGS chip dsign for th molcular diagnosis of gntic disas, cost analysis using ABC modl for an app Liguria Covillo Domnico Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD NET Crtification, quality and cost analysis of gntic tsting, and assssmnt of gntic counslling offrd by gntic srvics. National survy and intrnational data bas connctions. OSPEDALE BAMBINO GESU' Lpri Francsca Romana Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD NET Cost analysis plan of nw gnomic tchnologis using diffrnt oprativ modls for an fficint bnchmarking and appropriat allocation of NHS rcourss. RIZZOLI Sangiorgi Luca Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD NET Th clinical risk managmnt in Mdical Gntics Pimont amoroso antonio Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD NET Coordination of larg national cohorts of patints with chronic HCV infction: data managmnt, monitoring and cntralizd data analysis. Istituto Suprior di Sanita' Kondili Lorta Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Stratgic us of nw DAA combinations in HCV patints with HIV and/or HBV coinfction Lombardia Massimo Puoti Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Difficult to trat HCV populations in th ra of nw dirct acting antivirals (DAAs) Lazio Gasbarrini Antonio Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET HCV infction in difficult to rach, vulnrabl, undrsrvd populations, and gndr issus. Emilia Romagna Villa Erica Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 146 di 356

147 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Pharmaco conomics of th nw DAAs for th tratmnt of chronic HCV infction Sicilia Craxì Antonio Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Fasibility and ffcts on body composition of a lif styl intrvntion with dit and xrcis in arly brast cancr (BC) patints. Liguria Gnnari Alssandra Biomdica Oncology 2 Chmo/Ditary Prvntion CDP NET Dvlopmnt of a clinical algorithm for a dynamic prognosistic assssmnt in patints with arly brast cancr ntrd in a lifstyl modifying intrvntion program IRCCS AOU San Martino IST (Gnova) BRUZZI PAOLO Biomdica Oncology 2 Chmo/Ditary Prvntion CDP NET Impact of a radical lifstyl intrvntion in arly brast cancr on th lvl of xprssion of slctd circulating mirna known to b rlatd to BC prognosis Istituto Scintifico Romagnolo Nanni Oriana Biomdica Oncology 2 Chmo/Ditary Prvntion CDP NET Evaluation of th impact on patint mtabolism of a lifstyl intrvntion, including Mditrranan Dit and Physical activity in arly brast cancr (BC) patints. Toscana Quinons Alfrdo Biomdica Oncology 2 Galvan Chmo/Ditary Prvntion CDP NET Pathways to Rcovry from Mntal Illnss. From rhabilitation to ducation and slf managmnt: th Rcovry Collg Modl.A study to valuat th impact of th partcipation to training groups basd on th Rcovry Capital approach on individual pathway Lombardia lucchi fabio Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Th rol of Usrs and Family Mmbrs in Pr Support.A study to assss mthods and practics of usrs involvmnt in mntal halth srvics dlivry and its impact on tratmnt outcoms, on th cultur of th srvic workforc and stakholdrs of local c Provincia autonoma Trnto D Stfani Rnzo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 147 di 356

148 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Supporting Organisations towards Coproduction and Rcovry: a pr accrditation procss among all th rlvant stakholdrs in th mntal halth fild to dsign, tst and implmnt an instrumnt to assss, monitor and support organisations that choos c Emilia Romagna Fioritti Anglo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Prsonalisation in Mntal Halth. A qualitativ rsarch on promising and bst practics to promot prsonalisation in mntal halth car plans and on th implmntation and valuation of innovativ intrvntions across th sits of th Projct. Friuli Vnzia Giulia Mzzina Robrto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Individualizd Car Plans (ICPs): Usrs and thir carrs in th "drivr's sat".a study to compar th outcoms of ICPs coproducd by usrs, thir carrs with mntal halth srvics ky workrs vs standard ICPs basd on th prminnc of profssionals. Pimont Gda Giovanni Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET fficacy and cost ffctivnss of Tlrhabilitation for post Strok and post Traumatic Brain Injury patints in comparison with usual trritorial rhabilitation, analyzd in two diffrnt organizational modls. S.CAMILLO Tonin Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET TELEREHABILITATION IN SEVERE ACQUIRED BRAIN INJURY: IS IT EFFECTIVE? NEUROLESI Calabrò Rocco Salvator Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET fficacy of Tlrhabilitation on motor and cognitiv disordrs in Parkinson's disas in comparison with standard rhabilitation MONDINO Sinforiani Elna Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Blind assssmnt of outcom masurs in Tlrhabilitation for nurological patints and cargivrs' burdn, and contribution to a randomisd non infriority clinical trial on patints with squla of Strok CARLO BESTA Raggi Albrto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 148 di 356

149 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Halth Tchnology Assssmnt of diffrnt car modls in tlrhabilitation Istituto Suprior di Sanita' Giacomozzi Claudia Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Non invasiv tools for arly survillanc of at risk populations Istituto Suprior di Sanita' Scattoni Maria Luisa Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD NET An intgratd spcialist wb ntwork for arly scrning of ASD MEDEA Moltni Massimo Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD NET EARLY BIRD DIAGNOSTIC PROTOCOL FOR AUTISM SPECTRUM DISORDERS (EARLY BIRD) STELLA MARIS Muratori Filippo Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD NET OMICS biomarkrs for bttr car in Autism Spctrum Disordrs Lazio Prsico Antonio Maria Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD NET Prdictors of outcoms in autism arly bhavioral intrvntion OSPEDALE BAMBINO GESU' Vicari Stfano Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD NET Dvlopmnt and standardization of a Cognitiv vokd potntials and Low rsolution computd tomography (LORETA) protocol in childrn with SCD and in agthnic matchd controls Vnto SAINATI LAURA Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET Dvlopmnt and standardization of a Nuro Cognitiv Protocol to valuat monolingual and bilingual infants, pr school and school ag childrn with Sickl Cll Disas Emilia Romagna palazzi giovanni Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 149 di 356

150 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Dvlopmnt and standardization of a Slp study qustionnair and Polysomnography protocol in a multithnic population of childrn with Sickl Cll Disas Lombardia MASERA NICOLETTA Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET Dvlopmnt and standardization of a MRI/MRA, Functional MRI protocol sinc young ag in a multithnic population of childrn with Sickl Cll Disas Campania PERROTTA SILVERIO Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET Improvd dtction of hippocampal and xtrahippocampal abnormalitis in tmporal lob pilpsy by an advancd MRI 3T protocol, including multiparamtric mapping (MPM), diffusion tnsor imaging (DTI) and artrial spin labling (ASL), to assss macrostruct MONDINO Vitali Paolo Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE NET Surgically tratabl tmporal lob pilpsy: in vivo 3T MRI, x vivo 7T MRI and histological corrlations CARLO BESTA Didato Giuspp Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE NET Brain ntworks involvd in tmporal lob pilpsy as rvald by EEG fmri co rgistration. A national multicntric study. Emilia Romagna Mltti Stfano Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE NET NET NET Study of host/virus intractions involvd in HIV control, in patint tratd with a multitargt antirtroviral (MT ART) thrapy during primary HIV infction (PHI). Virologic volution in diffrnt compartmnts in patints rciving multitargt antiviral thrapy (MT ART) during primary HIV infction (PHI) Lymphoid architctur and homostasis in lymphnods, gut and priphral blood in HIV infctd patints during primary HIV infction (PHI) and changs upon multitargt antirtroviral thrapy (MT ART) SAN RAFFAELE MILANO Tambussi Giuspp Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Lombardia Rusconi Stfano Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Lombardia Marchtti Giulia Carla Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 150 di 356

151 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET NET Plasma, intracllular and tissu concntrations rachd by a multitargt antirtroviral thrapy (MT ART) during th tratmnt of patints with primary HIV infction (PHI): a pharmacokintic/pharmacodynamic study Nw modl of Primary HIV infction (PHI) managmnt: idntification of PHI, standardization of antirtroviral tratmnt and data collction in a nationwid Italian ntwork (INACTION) Pimont Calcagno Andra Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Lombardia Muscatllo Antonio Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE NET ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: COMPARATIVE ANALYSIS OF CUMULATIVE INCIDENCE OF PREMATURITY RELATED DISEASES BETWEEN PATIENTS RECEIVING CORD BLOOD OR ADULT BLOOD Lazio Zini Gina Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET ALLOGENEIC TRANSFUSION OF RED BLOOD CELL (RBC) CONCENTRATES FROM CORD BLOOD IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: MICROPARTICLE CHARACTERIZATION IN CORD BLOOD AND ADULT DONOR RBC UNITS. CASA SOLLIEVO SOFFERENZA SANTODIROC CO MICHELE Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET ALLOGENEIC TRANSFUSION OF CORD BLOOD RED BLOOD CELL (RBC) CONCENTRATES IN EXTREMELY LOW BIRTH WEIGHT NEONATES: COMPARISON OF IMMUNOMODULATION AND EFFECT ON LYMPHOCYTE SUBSETS EXERTED BY CORD BLOOD OR ADULT BLOOD PRODUCTS. Abruzzo Accorsi Patrizia Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB NET ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS. Calabria Princi Domnica Clinicoassistnzial Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 151 di 356

152 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Novl approachs to th diagnosis of subclinical, unapparnt or latnt socially rlvant infctious disass in immigrants in Italy and idntification of prognostic indxs basd on th spcific immun rspons signatur Istituto Suprior di Sanita' Svrini Carlo Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Assssmnt of th prvalnc, clinical and virological charactristics of Viral Hpatitis in immigrants through th implmntation of diffrnt scrning and prvntion adjustd to social nvironmnt Lombardia Castlli Francsco Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Implmntation of diagnostic mthod for diagnosis of tubrculosis in rcntly immigrants from TB high ndmic ara Lazio Lichtnr Miriam Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Scrning for infctious disass in rcnt migrants and valuation of th spcific immun rsponss for diagnosis drivn tratmnt and prvntion stratgis. Calabria Torti Carlo Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Scrning for clinically unapparnt infctious disass at high social impact in rcntly immigrants from Africa for arly diagnosis and appropriat tratmnt Puglia Angarano Gioacchino Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Improving Transition Procss in major psychoss MEDEA Martinuzzi Andra Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Transition in Cystic Fibrosis: comparing managmnt modls to improv quality of car OSPEDALE BAMBINO GESU' lucidi vincnzina Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Improving Transition Procss in svr Myopathis GASLINI Mintti Carlo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Psychosocial and biological factors influncing th transition from adolscnc to arly adulthood Istituto Suprior di Sanita' Anglo Picardi Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 152 di 356

153 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Improving transition for autism spctrum disordrs Lombardia Politi Pirluigi Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Dynamic MR imaging of th plvic floor functional disordrs: a comparison btwn sitting and supin position. Sicilia Midiri Massimo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT NET Dynamic MR imaging of th plvic floor functional disordrs: a comparison btwn sitting and supin position. Campania GRASSI ROBERTO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT NET Dynamic MR imaging of th plvic floor functional disordrs: a comparison btwn sitting and supin position. Lazio Orlacchio Antonio Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT NET Epidmiological survillanc in contaminatd sits: improvmnts in study dsign and implmntation of SENTIERI KIDS Projct Istituto Suprior di Sanita' Comba Pitro Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis ZRSS NET Cancr incidnc in contaminatd sits, with a focus on childrn Toscana Croctti Emanul Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis ZRSS NET Individual basd cohort studis on air quality and cardiorspiratory disass in industrial sits: indicators for public halth policy Lazio Ancona Carla Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis ZRSS NET Environmnt rlatd disass in contaminatd sits: th rspons of halth srvics Pimont Magnani Corrado Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis ZRSS NET Molcular markrs and innovativ tchnologis prdictiv of succsful tratmnt discontinuation in CML patints rciving tyrosin kinas inhibitors Pimont Saglio Giuspp Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 153 di 356

154 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Profil of Bon Marrow micronvironmnt biological markrs in CML patints tratd with TKIs: dvlopmnt a novl diagnostic tools Campania Pan Fabrizio Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET Optimization of TKIs Multipl Approachs and quality of lif (QoL) in ldrly patints (60 yars of ag or oldr) with Ph+ chronic myloid lukmia (CML) and MR3.0 / MR4.0 stabl molcular rspons Lombardia Russo Domnico Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET High rsolution gnomic and mtabolic charactrization of lukmia stm clls to prdict succssful tratmnt discontinuation in chronic myloid lukmia patints Emilia Romagna Martinlli Giovanni Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET Pdiatric ataxias in Italy: pidmiological studis and disas rgistry, dvlopmnt of a multi lvl informatic platform for clinicians and familis, and implmntation of guidlins for diagnosis, managmnt and car within th National Halth Systm Istituto Suprior di Sanita' Vanacor Nicola Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD NET Improving gntic diagnosis of pdiatric ataxias: idntification of novl gntic dtrminants, larg scal molcular scrnings and gnotyp phnotyp corrlats by us of stat of th art gnomic tchnologis CASA SOLLIEVO SOFFERENZA Valnt Enza Maria Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD NET Dvlopmnt of innovativ low cost, widly accssibl tchnologis for quantitativ assssmnt and hom basd rhabilitation of motor function in pdiatric ataxias OSPEDALE BAMBINO GESU' Brtini Enrico Silvio Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD NET Cognitiv and bhavioral dfcts in non progrssiv pdiatric ataxias: systmatic cognitiv profiling, innovativ nuroimaging studis and dvlopmnt of lowcost, widly accssibl tchnologis for prsonalizd hom basd rhabilitation MEDEA Borgatti Rnato Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD NET Standardizing virological mthods for th diagnosis, monitoring and prsymptomatic tratmnt of CMV and EBV infctions in adult and pdiatric stm cll transplant rcipints. Emilia Romagna Lazzarotto Tiziana Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 154 di 356

155 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET survillanc modls and viral DNA cut off for prsymptomatic tratmnt of CMV and EBV infctions in adult high risk stm clls transplant rcipints. Lombardia Farina Claudio francsco Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET survillanc modls and viral DNA cut off for prsymptomatic tratmnt of CMV and EBV infctions in pdiatric stm clls transplant rcipints SAN MATTEO Giorgiani Giovanna Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET survillanc modls and viral DNA cut off for prsymptomatic tratmnt of CMV and EBV infctions in adult and pdiatric low risk stm clls transplant rcipints. Lazio Gntil Giuspp Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Evaluation of CMV and EBV spcific cllular immun rsponss in hmatopoitic stm cll transplant rcipints to prvnt and control viral infction. Pimont Cavallo Rossana Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS NET Gndr orintd molcular charactrization of Hpatocllular Carcinoma (HCC) associatd with Diabts and Obsity: impact on clinical aggrssivnss and survival. Emilia Romagna D Maria Nicola Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET Activ scrning for chronic livr disas and HCC in diabtics and gndr orintd pidmiology via th RER Diabts Car Nt Emilia Romagna Manicardi valria Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET Comparativ imaging and locorgional tratmnt outcom in diabts/nash vs. viral HCCs ARCISPEDALE massari marco Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET Gndr burdn assssmnt in dvlopmnt, progrssion, thrapy and slf managmnt of diabts, obsity and rlatd conditions Emilia Romagna Signani Fulvia Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 155 di 356

156 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Fcal Microbiota Transplantation (FMT) program: Ralization of rgional rfrral cntrs for th tratmnt of rcurrnt Clostridium difficil infction by FMT. Lazio Cammarota Giovanni Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Fcal Microbiota Transplantation (FMT) program: Ralization of rgional rfrral cntrs for th tratmnt of rcurrnt Clostridium diffcil infction by FMT. Emilia Romagna Bazzoli Franco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Fcal Microbiota Transplantation (FMT) program: Ralization of rgional rfrral cntrs for th tratmnt of rcurrnt Clostridium diffcil infction by FMT. Lombardia Maconi Giovanni Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Fcal Microbiota Transplantation (FMT) program: Ralization of rgional rfrral cntrs for th tratmnt of rcurrnt Clostridium diffcil infction by FMT. Abruzzo Nri Matto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Griatric outcoms among oldr Typ 2 diabtic patints tratd with DPP4 inhibitors or glinids: focus on proinflammatory and oxidativ strss markrs I.N.R.C.A. Lattanzio Fabrizia Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET Griatric outcoms among oldr Typ 2 diabtic patints tratd with DPP4 inhibitors or glinids: focus on physical functioning Lazio Brnabi Robrto Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET Griatric outcoms among oldr Typ 2 diabtic patints tratd with DPP4 inhibitors or glinids: focus on cognitiv functioning Campania Paolisso Giuspp Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO NET A sustainabl stratgy for th prvntion of rcurrncs and risk rduction in brast cancr patints basd on prmannt lif styl modifications: a randomizd intrvntion trial to valuat a on yar protocol aimd to obtain ditary and physical activit Toscana Palli Domnico Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC NET Evaluation of th clinical prformanc of Digital Brast Tomosynthsis (DBT) as a primary tst for brast cancr scrning: a multicntr randomizd trial Pimont Sgnan Nro Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 156 di 356

157 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Idntification of a tailord protocol and a risk rduction stratgy for brast cancr in affctd and unaffctd BRCA1/2 carrirs and in familial brast cancr high risk subjcts Evaluation of th fasibility of th protocol in diffrnt aras in th Toscana Caligo Maria Adlaid Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC NET Digital brast tomosynthsis as a primary tst for brast cancr scrning: assssmnt of safty, accuracy, costffctivnss and organizational impact. Emilia Romagna Giorgi Rossi Paolo Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC NET Human mous co clinical trials to tailor chmothrapy for ovarian cancr Pimont Katsaros Dionyssios Biomdica Oncology 2 Cancr Biomarkrs NET NET NET Idntification of a panl of biomarkrs abl to prdict rspons to bvacizumab in womn with advancd highgrad srous ovarian cancr rciving noadjuvant chmothrapy Targtd thrapy in ovarian cancr with novl antiangiognic and anti PARP drug combinations: fficacy and prdictiv biomarkrs XENO PATIENTS co clinical trial to validat novl tratmnt modalitis in ovarian cancr Lazio Scambia Giovanni Biomdica Oncology 2 I.E.O. COLOMBO NICOLETTA Biomdica Oncology 2 MARIO NEGRI Giavazzi Raffalla Biomdica Oncology 2 Cancr Biomarkrs Cancr Biomarkrs Cancr Biomarkrs NET Crbral Cavrnous Malformations: from clinic to disas mchanisms toward prvntion and tratmnt Lombardia Fontanlla Marco Maria Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP NET Crbral Cavrnous Malformations: from clinic to disas mchanisms toward prvntion and tratmnt Pimont Rainro Innocnzo Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP NET Crbral Cavrnous Malformations: from clinic to disas mchanisms toward prvntion and tratmnt Toscana Battistini Stfania Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 157 di 356

158 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Crbral Cavrnous Malformations: from clinic to disas mchanisms toward prvntion and tratmnt Vnto dnaro luca Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP NET Crbral Cavrnous Malformations: from clinic to disas mchanisms toward prvntion and tratmnt Abruzzo Splndiani Alssandra Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP NET A translational approach to invstigat th biomolcular rol of Vitamin D in pdiatric obsity and insulin rsistanc Pimont Bona Gianni Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD NET Micro RNA Rgulation: Undrstanding, prdicting, diagnosing and tratingnafld and obsity rlatd complications in Childhood Emilia Romagna Strt Maria Elisabth Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD NET Effcts of prfluorinatd chmicals (PFCs) lvls on growth and insulin rsistanc innonats born with adquat or low wight for gstational ag Emilia Romagna Prdiri Barbara Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD NET NET NET WP1. Dvlopmnt of mtagnomics modls for culturindpndnt dtction and typing of zoonotic pathogns and study of thir intractions with th microbiota in th whol animal to human transmission chain WP2. Dvlopmnt of a nxt gnration squncing (NGS) basd survillanc systm nabling multi gnom comparisons and improving th control of vctor born viral disass WP3 Dvlopmnt of a nxt gnration squncing (NGS) basd survillanc systm nabling multi gnom comparisons for th ffctiv control of infctious disass at th animal human intrfac and foodborn zoonoss Istituto Suprior di Sanita' Morabito Stfano Biomdica Vtrinary Food Safty FOSA IZSAM Cammà Csar Biomdica Vtrinary Food Safty FOSA IZSVE Monn Isablla Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 158 di 356

159 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET WP4 Dvlopmnt of a nxt gnration squncing (NGS) basd survillanc systm nabling multi gnom comparisons and improving th control of disass causd by protozoa IZSSI VITALE FABRIZIO Biomdica Vtrinary Food Safty FOSA NET addd valu of MEG in surgical planning and patints managmnt and outcom in patints who will undrgo to brain surgry for low grad brain tumors, vascular malformations or pilpsy CARLO BESTA Francschtti Silvana Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Evaluation of th cost bnfit ratio of Magntoncphalography (MEG) to optimiz slction of Strok and Mild Cognitiv Impairmnt patints rquiring arly, intnsiv and prolongd rhabilitation. S.CAMILLO Piccion Francsco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Application of high dnsity EEG and fmri in pilpsy and nurorhabilitation Vnto Manganotti Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Impact of Magntoncaphalography in th diagnosis and follow up of schizophrnic patints Abruzzo Di Giannantonio Massimo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Dfining a nw diagnostic and prognostic biomarkrs tool in low risk prostat cancrmanagmnt. PASCALE Prdonà Sisto Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET Dfining a nw diagnostic and prognostic biomarkrs tool in low risk prostat cancrmanagmnt. Pimont Muto Giovanni Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET Dfining a nw diagnostic and prognostic biomarkrs tool in low risk prostat cancrmanagmnt. Calabria damiano rocco Clinicoassistnzial Oncology 2 Cancr Biomarkrs NET Implmnt tchnical architctur, data flow organization and scurity control systms to xtnd th rgional tlpathology ntwork to a national nvironmnt. NEUROLESI Mazzon Emanula Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 159 di 356

160 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET A projct for stablishing a tlpathology srvic for Anatomic Pathology using whol slid imaging. C.R.O. AVIANO Carbon Antonino Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET A projct aimd to stablish/implmnt a tlpathology ntwork and srvic in slctd Anatomic Pathology subspcialtis REGINA ELENA Pscarmona Edoardo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Campania Thlpathology Ntwork : focus on colorctal and skin tumors immunoscor. PASCALE Botti Grardo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Whol slid imaging tlpathology in pdiatric tumors and soft tissu sarcomas diagnosis. Whol slid imaging tlpathology applicability to in situ molcular pathology ISTITUTO TUMORI MILANO Collini Paola Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET INFLUENCE OF DIFFERENT BETABLOCKERS ON HEART FAILURE PROGNOSIS. A PROSPECTIVE ANALISYS MONZINO Agostoni Pirgiuspp Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR NET Brathing pattrn during slp and wakfulnss in congstiv hart failur patints AUXOLOGICO Lombardi Carolina Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR NET Evaluation of prognostic accuracy of a multi markr modl including MECKI scor and svral cardiac risk biomarkrs according to th principls of Evidnc Basd Laboratory Mdicin and Intrnational Rcommndd Critria Toscana Clrico Aldo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR NET ROLE OF RESTING AND EXRECISE CHRONOTROPIC VARIABLES IN THE PROGNOSIS OF PATIENTS AFFECTED BY HEART FAILURE: NEW INSIGHTS OF THE MECKI SCORE Campania PERRONE FILARDI PASQUALE Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 160 di 356

161 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET A prospctiv validation of MECKI scor in idiopathic dilatd cardiomyopathy: is it tim for improving th prognostic stratification of this rar disas? Friuli Vnzia Giulia Mrlo Marco Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR NET Hom monitoring of th atrial fibrillation burdn. Toscana Padltti Luigi Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Mtabolic and cardiac hom monitoring in complicatd hart failur/diabtic patints. MULTIMEDICA Gnovs Stfano Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Stratgis to manag patints with chronic obstructiv lung disass and hart failur at hom. Toscana Prdiltto Rnato Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Prvnting Hart Failur progrssion by hom monitor and support at an arly stag. Campania Trimarco Bruno Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Prvnting Hart Failur progrssion by hom monitor and support at an arly stag. Lombardia LUNATI MAURIZIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Charactrization of th patint's gnom for clinical dcision making in mylodysplastic syndroms (MDS) SAN MATTEO DELLA PORTA MATTEO GIOVANNI Clinicoassistnzial Oncology 2 Oncology CONC NET Prospctiv valuation of a KIT adaptd tratmnt of cor binding factor lukmia (CBFL) in adults and intgratd gntic analysis: a multi cntr phas II study Lombardia Morra Enrica Clinicoassistnzial Oncology 2 Oncology CONC NET Prvalnc and clinical significanc of c KIT somatic mutations in hyprosinophilic syndroms MAGGIORE Cortlzzi Agostino Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 161 di 356

162 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Diffus larg B cll lymphoma (DLBCL) with dysrgulation of c myc gn xprssion. Disscting th pathological and molcular htrognity to support tailord tratmnt stratgis Lombardia Rossi Giuspp Clinicoassistnzial Oncology 2 Oncology CONC NET Dfinition of patint's uniqu gntic profil to guid thraputical dcision making in myloprolifrativ noplasms (MPN) Lombardia Passamonti Francsco Clinicoassistnzial Oncology 2 Oncology CONC NET Clonal composition of synchronous colorctal tumors to addrss fild ffct(s) thory. HUMANITAS Malsci Albrto Biomdica Oncology 2 Cancr Biomarkrs NET NET NET NET Epigntic profils of arly onst, synchronous and mtachronous colorctal cancrs. NGS basd gnomic profiling of synchronous and mtachronous tumors arising in patints with attnuatd polyposis Epidmiological, clinical and molcular charactrization of juvnil CRC. MicroRNA xprssion profils as prdictors of colorctal cancr prdisposition Emilia Romagna RICCIARDIELL LUIGI O Biomdica Oncology 2 C.R.O. AVIANO Fornasarig Mara Biomdica Oncology 2 REGINA ELENA Stigliano Vittoria Anna Biomdica Oncology 2 Lazio GENUARDI MAURIZIO Biomdica Oncology 2 Cancr Biomarkrs Cancr Biomarkrs Cancr Biomarkrs Cancr Biomarkrs NET Prinatal factors associatd with rspiratory infctions and thir squla: th Piccolipiù birth cohort and th ntwork of Pdiatric Hospitals Toscana Rusconi Franca Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS NET Air pollution xposur, socioconomic charactristics of th family, prinatal matrnal psychological distrss and child nurodvlopmnt: th Piccolipiù birth cohort and th ntwork of Pdiatric Hospitals BURLO GAROFALO Ronfani Luca Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS NET Early risk factors of ovrwight and obsity in young childrn: th Piccolipiù birth cohort and th ntwork of Pdiatric Hospitals Lazio PORTA DANIELA Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 162 di 356

163 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Early pigntic markrs of childhood disass: th Piccolipiù birth cohort and th ntwork of Pdiatric Hospitals Pimont Richiardi Lornzo Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS NET Communication stratgis to parnts for vidnc basd prvntiv practics in childhood: th Piccolipiù birth cohort and th ntwork of Pdiatric Hospitals OSPEDALE BAMBINO GESU' Bozzola Elna Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS NET Modling currnt prinatal and nonatal data to prdict infant outcoms and provid tools for masuring and improving quality of car Lombardia zanini rinaldo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Magnsium Sulphat to prvnt nurologic damag following prtrm birth Lombardia FERRAZZI ENIRCO M. Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Ultrasound accuracy in assssing crbllar hamorrhags in Vry Low Birth Wight infants Liguria ramnghi luca antonio Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Ara basd Emilia Romagna Nonatal Ntwork: outcom of VLBW infants at two yars Emilia Romagna FERRARI FABRIZIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Prospctiv longitudinal approach to th small ftus: how diffrnt pattrns of ftal growth impact on nonatal morbidity and auxological, nurodvlopmntal and mtabolic outcoms at 2 yars of corrctd ag. Pimont Brtino Enrico Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Th mrgncy urgncy ntwork rationalization and th dvlopmnt of a disas managmnt manual Lombardia Agostoni Elio Clmnt Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NET Th Hub and Spok procss for th ndovascular tratmnt of acut ischamic strok Friuli Vnzia Giulia Elopra Robrto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 163 di 356

164 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. NET Th us of tlstrok systm to improv acut strok car Vnto Giomtto Bruno Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD PE Exndin 4 improvs insulin signaling in priphral targt tissus by modulating inflammatorypathways. Calabria Ssti Giorgio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO PE Clustring of Autism Gntic, Epigntic, and Functional Connctivity data in a multidimnsional spac. MEDEA Giorda Robrto Biomdica Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD PE Msnchymal Stm Clls and photoactivabl Nanoparticls: a novl Anticancr Photothrapy Systm for High grad Ostosarcoma Tratmnt (SNAPSHOT) RIZZOLI DONATI DAVIDE MARIA Biomdica Oncology 2 Dvlopmntal Thraputics DT PE Graft function amlioration of organs from non hart bating donors by x vivo prfusion withth nw oxygn carrir Hmarina M101 (HEMO2Lif ). SAN MATTEO PELLEGRINI CARLO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT PE Dfinition and Prvalnc of subclinical REM Slp Bhavior Disordr among Patints Attnding Slp Disordrs Cntrs Associazion Oasi Maria SS Frri Raffal Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS PE Ostopontin rgulation of B cll lymphomagnsis, undr chronic antignic stimulation, modls diffus larg B cll lymphoma. ISTITUTO TUMORI MILANO Colombo Mario Paolo Biomdica Oncology 1 Basic Tumor Micronvironmnt TME PE Undrstanding th rol of TM9SF4 in th malignant progrssion of skin cancrs. Prclinical studis on a nw biomarkr associatd with drug rsistanc and invasivnss of mlanoma clls Istituto Suprior di Sanita' Lozupon Francsco Biomdica Oncology 1 Basic Molcular Oncognsis MONC PE Rol of lipid rafts in th immun rspons to fungal infctions. Istituto Suprior di Sanita' Gagliardi Maria Cristina Biomdica Immunology Immunity and Host Dfns IHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 164 di 356

165 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Imaging of systmic molcular vnts during mammary tumorignsis as a novl approach for th idntification of nw clinically usful tumour biomarkrs. REGINA ELENA Piaggio Giulia Biomdica Oncology 2 Cancr Biomarkrs PE Targting th Syndcan 1/ADAM10 drivn angiognic pathway in solid tumors. IRCCS AOU San Martino IST (Gnova) Carnmolla Maria Barbara Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM2 PE PE TNFalpha/CCL2/strogn rcptor axis in th pathognsis and thrapy of inflammatory bowl disass Typ I IFN inducd altration of th vitamin D systm: a mchanistic insight into intrfronopathis Istituto Suprior di Sanita' Gssani Sandra Biomdica Immunology Innat Immunity And Inflammation III Istituto Suprior di Sanita' Gauzzi Maria Cristina Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS PE A rsarch platform for dvlopmnt of mirna basd thraputic stratgis against multipl myloma Calabria Tasson Pirfrancsco Biomdica Oncology 2 Dvlopmntal Thraputics DT PE ROLE OF ß CATENIN SIGNALING IN PROMOTING MACROPHAGE DRIVEN INFLAMMATION AND FIBROSIS IN FIBROCYSTIN DEFECTIVE LIVER DISEASE Vnto Fabris Luca Biomdica Cll Biology Intrcllular Intractions ICI PE Idntification of disas biomarkrs and innovativ thraputic options for hrditary nuropathis IRCCS AOU San Martino IST (Gnova) Schnon Anglo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Glia CMBG PE Homr mglu5 scaffold as common abnormal mchanism and thraputic targt for Intllctual Disability (ID) and Autism Spctrum Disordrs (ASD) Associazion Oasi Maria SS Catania Maria Vincnza Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Molcular Nuropharmacology and Signaling MNPS PE ANTIBODIES IN SINGLE CHAIN FORMAT AGAINST THE E6 AND E7 ONCOPROTEINS AS A NEW TREATMENT FOR THE HPV ASSOCIATED DISEASES Istituto Suprior di Sanita' Accardi Luisa Biomdica Oncology 2 Dvlopmntal Thraputics DT PE Rol of Ch 1 in multipl myloma cll growth and progrssion REGINA ELENA Fanciulli Maurizio Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 165 di 356

166 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Lukocyt tlomr lngth (LTL), mitochondrial DNA (mtdna) copy numbr and multipl myloma (MM) suscptibility and survival. Toscana Buda Gabril Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC PE Novl pathways in PNS mylination and rmylination SAN RAFFAELE MILANO Tavggia Carla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Glia CMBG PE Molcular dtrminants of muscl pricyts dysfunction in diabts mllitus MULTIMEDICA Spintti Gaia Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB PE Targting oncognic pigntic factors as an innovativ anticancr stratgy in Rhabdomyosarcoma OSPEDALE BAMBINO GESU' Rota Rosslla Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP PE Hmatopoitic stm cll transplantation for malignant forms of Multipl Sclrosis. Toscana riccardo saccardi Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT PE OSTEOCHONDRAL SCAFFOLD FUNCTIONALISATION BY BIOCOMPETENT DENDRONS RIZZOLI Giavarsi Gianluca Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE PE Brain Mchanisms of Chronic Subjctiv Dizzinss SANTA LUCIA Indovina Iol Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Auditory Systm AUD PE Rstoring th ntric nrvous systm: nural prognitors drivd from Amniotic Fluid and Placnta Stm Clls for novl approachs in th tratmnt of Hirschsprung's disas and intstinal dysganglionosis Vnto Giacomllo Luca Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD PE From monognic forms of Crohn s Disas to novl modls for dvloping non immunosupprssiv tratmnts. BURLO GAROFALO BIANCO ANNA MONICA ROSARIA Clinicoassistnzial Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 166 di 356

167 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Impact of carotid ndartrctomy and stnting on hmodynamics, fluid structur intraction, autonomic modulation, and cognitiv brain function. SAN RAFFAELE MILANO Marrocco Trischitta Massimiliano Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS PE Nw molcular biomarkrs and thraputic targts in urologic cancrs Calabria Blfior Antonino Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM2 PE NEW ANTI HCV VACCINES BASED ON ENGINEERED EXOSOMES Istituto Suprior di Sanita' ruggiri anna Biomdica Immunology Vaccins Against Microbial Disass VMD PE Markrs of prdiction of sorafnib snsitivity in primary livr carcinoma HUMANITAS RONCALLI MASSIMO Biomdica Oncology 2 Cancr Biomarkrs PE Human xprimntal modls for prclinical validation of xmstan in th tratmnt of msothlioma and to idntify novl biomarkrs involvd in drug rspons REGINA ELENA Galati Rosslla Biomdica Oncology 2 Cancr Biomarkrs PE Rol of th Association btwn Oxidativ strss, Inflammation and Innat Immun Systm Rspons in th Survival and Function of Pancratic Bta Clls SAN RAFFAELE PISANA DELLA DAVID Biomdica Endocrinology, MORTE Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO PE Evaluation of antitumor activity of claudin3 spcific immunotoxin in th tratmnt of rcurrnt chmothrapy rsistant ovarian and utrin cancrs. Lombardia RAVAGGI ANTONELLA Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII PE Idntification of a prognostic mirna signatur in HG PIN and dvlopmnt of artificial thraputic mirnas to prvnt prostat cancr progrssion. Liguria Campodonico Fabio Biomdica Oncology 2 Cancr Biomarkrs PE Nutrint Strss and Epigntic Control of HIV 1 Gn Exprssion SAN RAFFAELE MILANO Poli Guido Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP PE An INTERvntion programm to incras th QUALity of long trm car facilitis th INTERQUAL projct I.N.R.C.A. Chiatti Carlos Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 167 di 356

168 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Intgration of Transcriptomics and Nxt Gnration Exom Squncing to Idntify Risk Variants in IgA Nphropathy Puglia COX SHARON Biomdica Digstiv, Kidny and NATASHA Urological Systms Cllular and Molcular Biology of th Kidny CMBK PE High nd and Low End Virtual Rality Systms for th Rhabilitation of Friality in th Eldrly AUXOLOGICO Riva Giuspp Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F01 PE Dvlopmnt of a novl immunothraputic approach in typ 1 diabts and autoimmun polyndocrin syndrom typ 3 variant: us of antisns oligonuclotids to PTPN22 gn variant conjugatd to immunoliposoms OSPEDALE BAMBINO GESU' Firabracci Alssandra Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun PE Functional charactrization of non coding rgulatory lmnts controlling SOX factors xprssion in mlanoma patints ARCISPEDALE Sancisi Valntina Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP PE Dravt syndrom: Effct of sizurs on th svrity of pilptic and cognitiv phnotyps in a mous modl CARLO BESTA Scalmani Paolo Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE PE Multidimnsional Approach in Griatric Oncology (MAGO) study: optimising surgical outcoms in frail oldr adults affctd by cancr. Emilia Romagna Ugolini Giampaolo Clinicoassistnzial Oncology 2 Oncology CONC PE Lptin as novl thraputic tool to control Mycobactrium tubrculosis infction via mtabolic manipulation Istituto Suprior di Sanita' Palma Carla Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP PE Prclinical dvlopmnt of a nw fnrtinid formulation with high bioavailability and activity against cancr stm clls Istituto Suprior di Sanita' Pgna Zunr Ann Biomdica Oncology 2 Dvlopmntal Thraputics DT PE Rscuing T cll dysfunction in Chronic Lymphocytic Lukmia by targting th Notch signaling pathway Istituto Suprior di Sanita' Fdl Giorgio Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 168 di 356

169 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE NOVEL TOOLS TO STUDY AND INHIBIT MALARIA PARASITES HOMING TO HUMAN BONE MARROW Istituto Suprior di Sanita' Silvstrini Francsco Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE PE Rol of th atypical chmokin rcptor ACKR2 xprssd by lymphatic vssls in mtastatic colonization HUMANITAS BONECCHI RAFFAELLA Biomdica Immunology Innat Immunity And Inflammation III PE Prospctiv, Randomizd, Multi Cntr Trial of Latral Trndlnburg vrsus Smi Rcumbnt Body Position in Mchanically Vntilatd Patints For Th Prvntion of Vntilator Associatd Pnumonia MAGGIORE Panigada Mauro Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS PE Mchanistic studis on th intrplay btwn short trm starvation and T cll immunothrapy for nuroctodrmal tumors GASLINI Prigion Ignazia Biomdica Oncology 1 Basic Tumor Cll Biology TCB PE Th us of languag in limb apraxia rhabilitation FATEBENEFRATELLI Mannti Rosa Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Idntification of mchanisms undrlying clinical htrognity in Phlan McDrmid syndrom through dtaild gnotyp/phnotyp corrlation, gn xprssion analysis, and systm biology approachs MEDEA Bonaglia Maria Clara Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD PE Lysosomal mdiatd cllular claranc as a nw stratgy for th thrapy of inhritd dmylinating nuropathis SAN RAFFAELE MILANO Bolino Alssandra Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Glia CMBG PE PHARMACOEPIGENETICS IN SKIN WOUND REPAIR: IMPLICATIONS FOR CHRONIC ULCER TREATMENT ISTITUTO DERMOPATICO DELL'IMMACOLATA Napolitano Monica Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR PE Unravling th rol of GLUL in th suscptibility to coronary hart disas spcifically affcting typ 2 diabts CASA SOLLIEVO SOFFERENZA Trischitta Vincnzo Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 169 di 356

170 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Ar micrornas 34 involvd in mood disordrs and in th rspons to pharmacological tratmnts? SANTA LUCIA Vntura Rosslla Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA PE Non coding DNA will fill th gaps in diagnostic and prognostic classifications of human lukmia. Umbria Di Giacomo Danika Biomdica Oncology 1 Basic Cancr Gntics CG PE Evaluation of th diagnostic accuracy of thr mmory tsts for arly Alzhimr's disas Lombardia Clrici Francsca Maria Alssandra Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Microfluidic organotypic modl of monocyt transndothlial migration to th joint for th scrning of promising thraputic stratgis in obs ostoarthritic patints GALEAZZI Lopa Silvia Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS PE Cllular transportrs rol in th pathognsis of chmothrapy inducd priphral nurotoxicity Lombardia Cavaltti Guido Anglo Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT PE Targting prsistnt bacilli to fight tubrculosis Istituto Suprior di Sanita' Giannoni Fdrico Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR PE Rol of nwly disclosd Vd1 T clls xprssing Natural Cytotoxicity Rcptors in th homostasis of gut associatd lymphoid tissu and in th physiopathology of inflammatory bowl disass and colon rctal cancr. HUMANITAS MAVILIO DOMENICO Biomdica Immunology Innat Immunity And Inflammation III PE Clonal analysis of pancratic ductal adnocarcinoma and rlatd mtastatic rgional and at distanc lymph nods as an aid to stratify patints for prsonalizd tratmnt. HUMANITAS zrbi alssandro Biomdica Oncology 1 Basic Cancr Gntics CG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 170 di 356

171 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Implication of vitamin D in gstational hyprtnsion and prclampsia. Sicilia Santoro Domnico Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F06 PE impact of thr dimnsional patint spcific dosimtry with Mont Carlo simulations in Pptid Radionuclid Radiation Thrapy. Basis for clinical protocols stablishd on dosimtric/radiobiological paramtrs. I.E.O. CREMONESI MARTA Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD PE Circulating micrornas as biomarkrs of chmothrapyrlatd cardiotoxicity and myocardial inflammation HUMANITAS CONDORELLI GIANLUIGI Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF PE Idntifying gns rsponsibl for familial diabts of th adulthood by nxt gnration squncing of th whol xom. CASA SOLLIEVO SOFFERENZA Prudnt Sabrina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD PE Gntic and arly nvironmntal dtrminants of mthylation pattrn in immun function gns: th contribution of singlton and twin birth cohorts. Istituto Suprior di Sanita' Stazi Maria Biomdica Gns, Gnoms and Antonitta Gntics Gntics of Halth and Disas GHD PE Early dvlopmnt of locomotion in crbral palsy childrn SANTA LUCIA Ivannko Yury Biomdica Biology of Dvlopmnt and Aging Dvlopmnt 2 DEV2 PE Joint dynamical HRV rsfmri analysis: a nw tool to invstigat cntral corrlats of ANS dysfunction in PD and Parkinsonisms. Toscana Tssa Carlo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Etiology and prvntion of typ 1 diabts Lombardia Antonio Toniolo Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 171 di 356

172 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Matrnal mtabolic conditions in prgnancy and childhood obsity: mchanisms involvd and disas burdn in Italy Pimont mrltti franco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN PE Rol of STAT3 signalling in control of muscl rgnration, growth and autophagy during ag rlatd dgnrativ nuromuscular disass SANTA LUCIA Latlla Lucia Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP PE Functional intractions of HTLV 1 protins controlling oncognic and inflammatory pathways I. O. V. Ciminal Vincnzo Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP PE Evaluation of drug mtabolism and transportrs (DMET) rlatd gntic polymorphisms in Multipl Myloma (MM) patints undrgoing high dos mlphalan thrapy Calabria Tagliafrri Pirosandro Biomdica Oncology 2 Cancr Biomarkrs PE From th stimat of HIV undiagnosd popl to th control of viral load: th implmntation of a ntwork of clinical cntrs to assss th HIV cascad in Italy Istituto Suprior di Sanita' SULIGOI BARBARA Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE PE Harnssing T cll rsponss against lukmia with CD1crstrictd TCRs spcific for slf lipid antigns SAN RAFFAELE MILANO Casorati Giulia Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT PE Human Papilloma Virus (HPV) Exploitation of th SUMO (Small Ubiquitin lik MOdifir) Pathway in HPVinducd cancrs. I.E.O. CHIOCCA SUSANNA Biomdica Oncology 1 Basic Molcular Oncognsis MONC PE Circulating cll drivd microvsicls in coronary artry disas: molcular signatur, functional proprtis, and prdictiv valu in coronary artry bypass graft patncy MONZINO Camra Marina Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS PE Application of Nxt Gnration Squncing (Ion Torrnt) for th molcular charactrization of non autoimmun diabts mllitus sinc nwborn to young adult in patints with uncrtain diagnosis GASLINI d'annunzio Giuspp Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 172 di 356

173 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE POTENTIAL BIOLOGICAL MARKERS AND MOLECULAR PROFILING OF HEPARAN SULFATES IN MO PATIENTS: EVALUATION OF PATHOPHYSIOLOGICAL PATHWAYS TO DEFINE A COMPLETE BIOCHEMICAL PROFILING FOR DIAGNOSIS AND PATIENTS FOLLOW UP RIZZOLI Locatlli Manula Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG PE Undrstanding th rol of msnchymal stromal clldrivd microvsicls in th inflammatory lukmic micronvironmnt OSPEDALE BAMBINO GESU' Brnardo Maria Estr Biomdica Oncology 1 Basic Tumor Micronvironmnt TME PE Tridimnsional biomimtic modls to improv brast cancr in vitro studis: ffct of th micronvironmnt on tumor bhavior, hypoxia rspons and drug rsistanc Istituto Scintifico Romagnolo Ibrahim Toni Biomdica Oncology 1 Basic Tumor Micronvironmnt TME PE Rol of Opisthorchis flinus, an mrging human parasit in Italy, in th dvlopmnt of cholangiocarcinoma in an animal modl of chronic infction. Istituto Suprior di Sanita' Pozio Edoardo Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE PE Epigntic, aging (lukocyt tlomr lngth), inflammatory markrs and gographical, sx rlatd diffrncs in cardiovascular disas (th EPI AGING study). MONZINO Baldassarr Damiano Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS PE Th oncognic potntial of th AID/APOBECs: involvmnt in tissu transformation and oncognsis nw tools to bttr modl cancr Toscana Conticllo Silvstro Biomdica Oncology 1 Basic Cancr Etiology CE PE Implmntation of FOLFIRINOX in th routin managmnt of pancratic cancr patints: clinical impact of dos/schdul modifications and additional supportiv masurs and potntial for pharmacognticsbasd stratgis for tratmnt slction and prson REGINA ELENA Millla Michl Clinicoassistnzial Oncology 2 Oncology CONC PE Th thraputic potntial of proxisom prolifratoractivatd rcptor PPAR gamma and its ligands as nw targts against infction by lntiviruss Istituto Suprior di Sanita' borstti alssandra Biomdica Immunology Immunity and Host Dfns IHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 173 di 356

174 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE BRAIN TUMOR RELATED EPILEPSY: AN UNCONVENTIONAL TREATMENT APPROACH BASED ON NEW KNOWLEDGE OF PATHOGENETIC MECHANISMS REGINA ELENA Maschio Marta Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT PE SYNCHRONIZATION of INHIBITION PRECEDES and PROMOTES EPILEPTIC SEIZURES CARLO BESTA d Curtis Marco Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE PE Multipotnt Amniotic Fluid drivd Stm Clls (AFS) may iinflunc Survival and Diffrntiation of Nuroblastoma Clls : a possibl Nw Thraputic Tool GASLINI Martuccillo Giuspp Biomdica Oncology 1 Basic Tumor Cll Biology TCB PE Coagulation/complmnt activation and crbral hypoprfusion in rlapsing rmitting multipl sclrosis REGINA ELENA Koudriavtsva Tatiana Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Structural protomics and solution charactrization of protins of biomdical/oncological intrst: dvlopmnt of a comprhnsiv facility, application to th fibrin(ogn) intgrins cll matrix intractions modl systm, and to th mchanism of fibrin fo IRCCS AOU San Martino IST (Gnova) Rocco Mattia Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function D MSFD PE Evaluation of immun rconstitution in patints givn TCR alpha bta/b cll dpltd haploidntical stm cll transplantation followd by th addback of donor T clls xprssing an inducibl Caspas9 suicid gn OSPEDALE BAMBINO GESU' pagliara daria Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII PE Adipos tissu prognitors, angiognsis and brast cancr mtastasis initiating clls. Idntification of targts and thraputic intrvntions I.E.O. BERTOLINI FRANCESCO Biomdica Oncology 2 Dvlopmntal Thraputics DT PE Improving standard of car: translating molcular portrait into clinically ffctiv tools to ovrcom ovarian cancr rcurrnc. ISTITUTO TUMORI MILANO Mzzanzanica Dlia Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 174 di 356

175 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Nxt gnration squncing of synchronous and mtachronous hpatic colorctal cancr mtastass to idntify prognostic biomarkrs and thraputic targts Lazio Nigri Giuspp Biomdica Oncology 1 Basic Riccardo Tumor Progrssion and Mtastasis TPM2 PE Chronic Kidny Disas as a Dysmtabolic Dtrminant of Disability among Oldr Popl (CKD 3D) I.N.R.C.A. Corsonllo Andra Clinicoassistnzial Population Scincs and Epidmiology Kidny, Nutrition, Obsity and Diabts KNOD PE REGULATION of IMMUNITY in PATIENTS UNDERGOING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION Emilia Romagna Arpinati Mario Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT PE Systmic safty of antiangiognic thrapy for intravitral us in rtinal vascular disas: systmatic rviw and ntwork mta analysis Toscana Virgili Gianni Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD PE Rol of hypoxia inducd non coding RNAs in priphral ischmia SAN DONATO Martlli Fabio Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB PE A rgistry of svr malaria in rturning travllrs from ndmic countris: clinical outcom and advrs vnts including hamatological and pharmacokintic data. NtwOrk for svr MALaria tratmnt NOMAL study SPALLANZANI Nicastri Emanul Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS PE Virtual and Augmntd Rality Support for Transcathtr Valv Implantation by usingcardiovascular MRI Toscana Positano Vincnzo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT PE Dos intnsiv xrcis induc plasticity rlatd changs in Parkinson's Disas? NEUROLESI Russo Marghrita Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Dvlopmnt of stm cll drivd METABO MIMETIC nanovsicls as nw thraputic approach to inflammation and cancr(metabo MIMETICS) SAN RAFFAELE MILANO Drago Dnis Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 175 di 356

176 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE A computr basd tool for ral tim classification of colorctal lsions dtctd by ndoscopy Sicilia Granata Antonino Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM PE Nuroblastoma prognostic biomarkrs in primary tumors and blood xosoms GASLINI Varsio Luigi Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM2 PE Rduction of brast cancr rcurrnc in womn: lifstyl stratgis and microrna xprssion PASCALE Montlla Maurizio Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP PE Idntification of nw gns involvd in th mylomagnsis and thir validation as nw thraputic targts in multipl myloma Emilia Romagna GIULIANI NICOLA Biomdica Oncology 1 Basic Molcular Oncognsis MONC PE Opioid tolranc in chronic pain patints: undrstanding th molcular mchanism for a nw thraputic approach SAN RAFFAELE PISANA Muscoli Carolina Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Somatosnsory and Chmosnsory Systms SCS PE Gastrointstinal (GI) disordrs associatd to ASDs: invstigating thir clinical charactristics and gnticsuscptibility along th brain gut axis Emilia Romagna Parmggiani Antonia Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD PE Targting th tumor stroma crosstalk to rstrain brast cancr rcurrnc. A translational approach: from bdsid to bnch and back C.R.O. AVIANO Blltti Barbara Biomdica Oncology 1 Basic Tumor Cll Biology TCB PE , structural and functional markrs for rcovry of consciousnss MAUGERI Estrano Anna Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Th E. coli cytotoxic ncrotizing factor 1 as a nw drug for countracting nrgtic dfcts in mitochondrial disordrs: a prclinical study. OSPEDALE BAMBINO GESU' Rizza trsa Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 176 di 356

177 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE ROLE OF ROTAVIRUS INFECTION IN THE PATHOGENESIS OF CELIAC DISEASE Istituto Suprior di Sanita' Silano Marco Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB PE Gntic dtrminants of Troussau Syndrom Lazio Mango Ruggiro Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD PE Bringing xposomics into systms mdicin: Study of th occupational and nvironmntal dtrminants of COPD SAN RAFFAELE PISANA BONASSI STEFANO AURELIO Clinicoassistnzial Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP PE Childhood apraxia of spch: nurobiological and bhavioural markrs and xprinc dpndnt changs of nural connctivity inducd by tratmnt. STELLA MARIS Chilosi Anna Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD PE PREDICTING THE FUTURE HEALTH CARE NEEDS OF CANCER SURVIVORS IN AGEING POPULATIONS (FORECARE) Istituto Suprior di Sanita' D Anglis Robrta Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC PE Small molcul quadruplx targtd drug discovry for a multimodal thrapy against colorctal tumor: Towards candidat slctions REGINA ELENA Biroccio Annamaria Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS PE Disscting th rol of micrornas in th radiation rspons of human prostat cancr ISTITUTO TUMORI MILANO Zaffaroni Nadia Biomdica Oncology 2 Radiation Thraputics and Biology RTB PE Advancd diffusion MRI mthods to improv dtction and charactrization of focal cortical dysplasias in surgically rmdiabl pilptic patints: an in vivo and x vivo study with nuropathological corrlation CARLO BESTA Zucca Ilana Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI PE ADAR2 mdiatd mir diting as a novl thraputic tool for glioblastoma thrapy OSPEDALE BAMBINO GESU' Gallo Angla Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 177 di 356

178 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE IDENTIFICATION OF DIETARY ASSOCIATED BIOMARKERS FOR THE PREVENTION OF CERVICAL CANCER THROUGH INTEGRATIVE AND EPIGENETIC APPROACHES Sicilia Agodi Antonlla Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP PE Host Hpatitis C virus intraction in diffrnt gographic aras: disas progrssion and rsistanc markrs Istituto Suprior di Sanita' ciccozzi massimo Biomdica Immunology Immunity and Host Dfns IHD PE Idntification of rliabl lipid markrs associatd with prostat cancr and valuation of autophagy and Myc modulators as possibl pharmacological tools to affct lipid profiling and prostat cancr phnotyp. PASCALE pucci biagio Biomdica Oncology 1 Basic Tumor Cll Biology TCB PE Nw Insights in th Etiology and Pathophysiology of Early Lif Functional Gastrointstinal Disordrs: rol of Microbiom and Environmntal Factors. Campania Mil Erasmo Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG PE Novl gnomic biomarkrs potntially usful in informing tratmnt dcisions and in prdicting drug toxicity: a rtrospctiv and prospctiv study in Luminal B brast cancr patints REGINA ELENA Cogntti Francsco Clinicoassistnzial Oncology 2 Cancr Biomarkrs PE Analysis of NLRP3 inflammasom as important nw thraputic targt in nurodgnrativ disass SANTA LUCIA Ciaramlla Antonio Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT PE Cllular vctors to maximiz th dlivry of standard chmothraputics to lung cancr SDN Parodi Alssandro Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD PE Influnc of statosis, intracllular lipid accumulation and lipophagy on th fficacy of th HCV NS5B polymras inhibitor SPALLANZANI Montalbano Marzia Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 178 di 356

179 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Intrplay btwn camp and RhoA pathways with filamin A: ffcts on pituitary tumors invasivnss and rspons to drugs MAGGIORE Mantovani Giovanna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE PE EFFECTS OF INFUSIONAL LEVODOPA CARBIDOPA THERAPY ON GAIT, FALLS AND POSTURAL INSTABILITY IN ADVANCED PARKINSON S DISEASE Emilia Romagna snsi mariachiara Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Dvlopmnt of vaccins to control salmonllosis using attnuatd strains with altrd mtaluptak capability IZSLER Alborali Giovanni Loris Biomdica Vtrinary Animal Halth ANHE PE Th function of Group I mtabotropic glutamat rcptor subtyps in absnc pilpsy NEUROMED Ngomba Richard Tk Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE PE Th us of cll migration modulators as a novl approach to nhanc vaccin inducd immunity in immuncompromisd hosts Istituto Suprior di Sanita' Vndtti Silvia Biomdica Immunology Vaccins Against Microbial Disass VMD PE SIGNATURES OF VOLITIONAL INHIBITION IN THE SUBTHALAMIC NUCLEUS: A ROAD FOR OPTIMIZING DEEP BRAIN STIMULATION PLACEMENT NEUROMED Mirablla Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Pancratic ductal adnocarcinoma (PDAC): dvlopmnt of a nw communication platform btwn radiologists, surgons and pathologists basd on virtual and 3D printd rconstructions of th pancras and th tumor mass. SAN MATTEO PIETRABISSA ANDREA Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM PE Prvntion of human advrs halth ffcts of ndocrin activ substancs: valuation of th quality of individual pidmiological studis, and quantitativ assssmnt of th impact basd on th ovrall toxicological and mchanistic data combind with pi Lombardia mortto anglo Biomdica Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD PE Mthods and tools to monitor trnds in HIV pidmic and th impact of prvntiv programs. SPALLANZANI Ippolito Giuspp Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 179 di 356

180 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Th rol of nutrophil xtracllular traps in rhumatoid arthritis: nw pathogntic mchanisms and novl targts for diagnosis and thrapy Toscana migliorini paola Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun PE Gntic dissction and functional charactrization of a nuronal plasma mmbran Ca2+ atpas in th pathognsis of congnital ataxia OSPEDALE BAMBINO GESU' Zanni Ginvra Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD PE Snsory and autonomic markrs in arly diagnosis of parkinsonism. A nw stratgy to prdict clinical volution toward diffrnt nruodgnrativ disordrs. MAUGERI Nolano Maria Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Influnza A Virus Evolution and Adaptation to Host Rstriction Factors SAN RAFFAELE MILANO Vicnzi Elisa Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB PE Vascular Cognitiv Dclin in Atrial Fibrillation: Advancd MRI nuroimaging and in dpth nuropsychological assssmnt of brain damag an dysfunction CARLO BESTA Boffano Carlo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE Undrstanding th rol of intracllular zinc rgulation in ndothlial and cardiac cllular snscnc I.N.R.C.A. Malavolta Marco Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF PE Charactrization of nurovascular coupling and brain functional rspons to hypoglycmia in Typ 1 diabts SANTA LUCIA Giov Fdrico Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD PE Dvlopmnt and pr clinical validation of a softtthrd ndoscopic robot to rplac colonoscopy as a scrning tool for colorctal cancr Pimont AREZZO ALBERTO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 180 di 356

181 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Innovativ humanizd mous modls for fast tracking th clinical translation of CAR T clls SAN RAFFAELE MILANO Bondanza Attilio Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII PE Th Linosa Projct: a whol island study on atypical hmolytic urmic syndrom Lombardia SCOLARI FRANCESCO Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD PE Statistical modl for brast cancr scrning intgrating individual risk factors: a cost ffctivnss analysis. Toscana Vntura Lonardo Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI PE Altrd VAPB dpndnt lipid mtabolism invstigatd in novl cll modls for ALS CARLO BESTA Brnasconi Pia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND PE Structural biomarkrs of awarnss and wakfulnss in disordrs of consciousnss CARLO BESTA Frraro Stfania Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PE An immunognomic Thrapy for Multipl Myloma C.R.O. AVIANO Michili Mariagrazia Biomdica Oncology 2 Dvlopmntal Thraputics DT PE Human intstinal organoids for nw thrapis Campania GRECO LUIGI Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS PE Nw stratgis for diagnosis and rhabilitation of impaird bodily slf rcognition in nurological patints with motor dficit following crbro vascular and dgnrativ disas MAUGERI Frassintti Francsca Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG PE In vivo assssmnt of th rol of Locus Corulus in th dvlopmnt of Alzhimr's Disas and othr typs of Dmntia. Toscana Giorgi Filippo San Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 181 di 356

182 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv. PE Dysrgulation of glycogn synthas kinas 3 signaling in mood disordrs: idntification of nw molcular targts, prognostic and rspons biomarkrs. Lazio JANIRI LUIGI Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA PE Endognous Rvrs Transcriptas as arly diagnostic biomarkr of cancr progrssion and as potntial targt for innovativ diffrntiation cancr tratmnt SAN RAFFAELE PISANA GUADAGNI FIORELLA Biomdica Oncology 2 Cancr Biomarkrs PE Intrabody mdiatd prion ablation as a novl gn basd antibody stratgy against Alzhimr's disas SAN RAFFAELE PISANA CARDINALE ALESSIO Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN PE Intgratd analysis of circulating and intramuscular myognic micro RNA as biomarkr of disas progrssion and rspons to pharmacological tratmnt in Duchnn Muscular Dystrophy patints. SANTA LUCIA Saccon Valntina Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Charactrization of th molcular mchanisms allowing Nuroblastoma clls to supprss immun survillanc and st up of biothraputic approachs capabl to countract thir ffcts. GASLINI Bottino Cristina Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Mtabolic profiling of cancr stm lik clls from glioblastoma patints: 1H NMR spctroscopic fingrprints coupld to biological, radiobiological and clinical data. Istituto Suprior di Sanita' Rosi Antonlla Biomdica Oncology 2 Cancr Biomarkrs Svn Tsla MR imaging as prclinical biomarkr in populations at risk for Parkinson disas Toscana Cosottini Mirco Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Mtabolomic profil of th amniotic fluid collctd during amniocntsis in th scond trimstr of gstation: prdictability for rnal and rspiratory disass in infancy Vnto Zaffanllo Marco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 182 di 356

183 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Targting pigntic rgulation of pro angiognic factors in malignant gliomas Vnto Cabrini Giulio Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Dvlopmnt of innovativ in vitro infction modls, basd on human cll rprogramming and gn diting, to invstigat th biology and pathognsis of nurotropic viruss and to tst nw antiviral molculs. Vnto Barzon Luisa Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB COMPARATIVE EFFICACY OF OMOLOGOUS BLOOD BASED EYEDROPS FROM DIFFERENT SOURCES IN THE TREATMENT OF SEVERE KERATOPATHY A RANDOMIZED CLINICAL TRIAL Emilia Romagna Vlati Claudio Vittorio Clinicoassistnzial Vascular and Hmatology Hmatology Small Businss Activitis SBIR/STTR SBHE Gnom basd dvlopmnt of nw diagnostic, virulnc and pidmiological markrs for nontubrculous mycobactria Emilia Romagna RUMPIANESI FABIO Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Humoral and functional charactrization of xtracllular ncrnas in pathognsis of Myotonic Dystrophy typ 1 SAN DONATO GRECO SIMONA Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Q fvr in Italy: pilot study to invstigat prsnc, diffusion and gntic divrsity of Coxilla burntii IZSAM Garofolo Giuliano Biomdica Gns, Gnoms and Gntics Gntic Variation and Evolution GVE Lycopn, Slnium and Polydoxyribonuclotid: a tripl thraputic approach in conditions of mal infrtility Sicilia Minutoli Lttria Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular, Molcular and Intgrativ Rproduction CMIR Emrging rol of Torqu Tno virus (TTV) in food chain IZSME Viscardi Maurizio Biomdica Vtrinary Food Safty FOSA Rol of glycosylation in Alzhimr's disas MARIO NEGRI Balducci Claudia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 183 di 356

184 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Early dtction and prvntion of subtl cognitiv dclin: nuropsychological and imaging signatur of asymptomatic at risk adults SANTA LUCIA Piras Fdrica Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Fasibility of ntwork among Hospitals to provid a high quality, cost ffctiv frtility prsrvation with ovarian tissu banking to girls and womn undrgoing gonadotoxic tratmnts. IRCCS AOU San Martino IST (Gnova) Ansrini Paola Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Sroprvalnc of Hpatitis E virus infction in Italian blood donors: a survy at national and rgional lvl Istituto Suprior di Sanita' Pisani Giulio Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP R organization of nural circuits bfor mmory loss in mic modls of Alzhimr s disas: xprimntal approach of th cognitiv rsrv concpt and implications for diagnosis and thrapy SANTA LUCIA Ammassari Martin Biomdica Brain Disordrs and Tul Nuroscinc Nuroscinc and Nurodgnration ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS Lombardia Brgni Marco Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII NSD1 PHD fingrs as potntial targts for Acut Myloid Lukmia SAN RAFFAELE MILANO Musco Giovanna Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function C MSFC Alcohol rlatd nurodvlopmntal disordrs: prvntion and arly diagnosis of ftal alcohol spctrum disordrs and ftal alcohol syndrom. Istituto Suprior di Sanita' Pichini Simona Biomdica Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA A molcular orintd approach as a slction tool for multimodal tratmnt of gastric cancr. Multicntr biomarkr validation conductd by th Italian Rsarch Group for Gastric Cancr (GIRCG) ntwork Toscana MARRELLI DANIELE Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 184 di 356

185 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv APRON: Assay for PRiONs. DEVELOPMENT OF AN ASSAY DETECTING PRIONS IN ANIMALS AND HUMANS AFFECTED WITH PRION DISORDERS IN A PRECLINICAL AND CLINICAL STAGE IZSPLV Casalon Cristina Biomdica Vtrinary Animal Halth ANHE Adipos tissu rlatd mchanisms and vascular dysfunction in diffrnt obs phnotyps. Lazio Tsauro Manfrdi Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Innovativ stratgis for ostochondral lsions tratmnt: nw stm cll sourcs and nw biomimtic polymric scaffold RIZZOLI Torriclli Paola Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Pancratic cancr thrapy basd on combination of DNA vaccination and PI3Kgammainhibition Pimont Novlli Francsco Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Functional and molcular charactrization of glutamatdpndnt mchanisms rgulating brain mtabolism in Alzhimr's disas March Amoroso Salvator Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Targtd multipl dy dopd NIR mitting silica nanoparticls as optical imaging probs for cancr diagnostic applications BURLO GAROFALO BIFFI STEFANIA Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Molcular Imaging and Prob Dvlopmnt CMIP Disscting th molcular ntwork of intrlukin 1ß in non alcoholic statohpatitis in ordr to idntify novl potntial thraputic targts OSPEDALE BAMBINO GESU' Alisi Anna Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Analysis of somatic mutations and rlatd altrd pathways for th idntification ofnw biomarkrs and molcular targts in tumors of th lowr fmal gnital tract PASCALE Tornsllo Maria Lina Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 185 di 356

186 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Invstigating th molcular mchanisms lading to gnom instability in tumours: analysis ofrol of th rplication strss rspons and its potntial for arly diagnosis and targt thrapy of cancr Istituto Suprior di Sanita' Pichirri Pitro Biomdica Oncology 1 Basic Cancr Gntics CG Rol of Extra virgin oliv oil in modulating post prandial oxidativ strss in Diabtic patints Lazio Pasqual Pignatlli Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO A MULTICENTRE PHASE II RANDOMIZED STUDY OF FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST AND SECOND LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER 2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. REGINA ELENA Vici Patrizia Clinicoassistnzial Oncology 2 Oncology CONC Signaling ntworks in crbllar nurodgnrativ disordrs and cancr: rol of Ataxia Tlangictasia Mutatd (ATM) kinas SANTA LUCIA Barilà Danila Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Non Alcoholic Fatty Livr Disas (NAFLD), vitamin D and cardiomtabolic risk: a proof of concpt study Lombardia Blli Luca Savrio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO MicroRNAs as a novl diagnostic biomarkrs for Non Alcoholic Fatty Livr Disas (NAFLD) and Non Alcoholic StatoHpatitis (NASH). Sicilia Purrllo Francsco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Mutant p53 controls post transcriptional mdiatd oncosupprssor mirnas maturation in colon cancr. REGINA ELENA gurtnr aymon Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Potntial impact of a traditional Mditrranan Dit on strogn, inflammation and cholstrol homostasis: a Brmuda triangl for CVD risk? Sicilia carruba giuspp Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 186 di 356

187 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th MINA PROJECT. Mirror Nurons In Alcoholics: can Mirror Nuron Systm hlp us toundrstand and trat Alcohol Addiction? Emilia Romagna Di Gnnaro Cristiana Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Abnormal phosphatidylcholin mtabolism as a bas for tailord molcular imaging and for thrapy targting in human tripl ngativ brast cancr Istituto Suprior di Sanita' Iorio Egidio Biomdica Oncology 2 Cancr Biomarkrs Implmntation and improvmnt of a prdicting modl of all caus mortality in patints with typ 2 diabts mllitus living in Apulia, Southrn Italy. CASA SOLLIEVO SOFFERENZA D Cosmo Salvator Clinicoassistnzial Population Scincs and Epidmiology Kidny, Nutrition, Obsity and Diabts KNOD Intgration, Harmonization and Standardization of laboratory tools for disas monitoring and outcom prdiction in non Hodgkin Lymphoma (NHL) in th contxt of th "Fondazion Italiana Linfomi" (FIL) ntwork Pimont Ladtto Marco Clinicoassistnzial Oncology 2 Cancr Biomarkrs MOTOR REHABILITATION IN SPINAL CORD INJURY: ENHANCING RECOVERY THROUGH COGNITION. Lombardia Bottini Gabrilla Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Anti SAP (scrtd aspartyl protinass) antibodis to fight mucosal and systmic candidiasis. Umbria Vcchiarlli Anna Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Dsign of a doubl facd nanostructurd wound drssing with rgnrativ and antimicrobial proprtis Istituto Suprior di Sanita' Baldassarri Lucilla Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO CDKL5 rlatd nurodvlopmntal disass: a multidisciplinary study in a novl mous modl to fostr fficint thraputic approachs SAN RAFFAELE MILANO Landsbrgr Nicoltta Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD STUDIES ON THE POTENTIAL USE OF EXTRACELLULAR VESICLES IN THE THERANOSTICS (THERAPY AND DIAGNOSIS, WHOLE IN ONE) OF CANCER Istituto Suprior di Sanita' Fais Stfano Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 187 di 356

188 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Diagnostic and thraputic dvics mitting lctromagntic filds: ffctivnss and safty for patints and workrs Istituto Suprior di Sanita' Polichtti Alssandro Biomdica Surgical Scincs, Vittorio Biomdical Imaging, and Bionginring Elctromagntic Dvics Spcial Emphasis Panl SEED LIPID NANOCARRIERS FOR PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Istituto Suprior di Sanita' MOLINARI AGNESE Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Modna Familial Cancr Clinic: organizing an halth car srvic dvotd to assss, counsl and manag popl with hrditary cancr syndroms. Emilia Romagna Cortsi Laura Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Thraputic stratgis against Influnza virus infction basd on lactofrrin drivd pptids Istituto Suprior di Sanita' Suprti Fabiana Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR A doubl blind randomizd controlld placbo trial to valuat th fficacy of oral ttrabnazin and trihxyphnidyl in patints with dyskintic crbral palsy STELLA MARIS Battini Robrta Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Effctivnss of rpatd immunizations with DNA plasmids ncoding HER 2/nu in th longtrm prvntion of mammary cancr in HER 2/nu transgnic mic I.N.R.C.A. Provinciali Mauro Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Cogan's Syndrom: application of functional nuroimaging to autoimmun crbral vssls' inflammation Emilia Romagna Mora Paolo Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun Idntification of innovativ thraputic stratgis rgarding mtastatic ovarian cancrs Sicilia Todaro Matild Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Prclinical and phas II clinical study of cisplatin, ctuximab and valproic acid in rcurrnt and/or mtastatic squamous cll carcinoma of th had and nck PASCALE Caponigro Francsco Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 188 di 356

189 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Gntic Assssmnt of Rproductiv Activity in BUffalo and CAttl IZSME CORRADO FEDERICA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Rol of anti pilptic drugs in pilpsy and psychiatric/nurologic comorbidity: a translationalstudy. Calabria D Sarro Giovambattista Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Cyclic joint loading and molcular cartilag homostasis: towards th dsign of rhabilitation programs limiting progrssion of human kn ostoarthritis RIZZOLI Lardini Albrto Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Structur and Rgnration SBSR CCR5 spcific antibody drivd mimtic pptid against HIV transmission SAN RAFFAELE MILANO Lopalco Lucia Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Mnopaus: Impact on cardiovascular Risk AugmntatioN and Outcom worsning (MIRANO) Study Vnto Tikhonoff Valri Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER A DCE MRI quantitativ indx for prdiction and arly assssmnt of rspons to no adjuvant radiochmothrapy in locally advancd rctal cancr (LARC) PASCALE Ptrillo Antonlla Clinicoassistnzial Oncology 2 Oncology CONC Strotactic body radiation thrapy (SBRT) with th Tomothrapy platform in primary and mtastatic lung and livr tumor Sicilia frrra giuspp Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Nw immunological markrs for improving th cur of inborn hamoglobinopathis by hmatopoitic stm cll transplantation Istituto Suprior di Sanita' Sanchz Massimo Biomdica Vascular and Hmatology Hmatopoisis HP TROPHIC ACTIVITY OF SPERMIDINE SUPRAMOLECULAR COMPLEXES IN OSTEOARTHRITIS RIZZOLI Borzi' Rosa Maria Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 189 di 356

190 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A mtabolomics approach to idntify abrrant signaling pathways in patints at risk for major cardiovascular vnts:studis in human subjcts with diabts and athrosclrosis Lazio Fdrici Massimo Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Targting Mycobactrium surfac constitunts as a novl vaccination stratgy against tubrculosis aimd at dvloping nutralizing antibodis. Lazio Dlogu Giovanni Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Slf monitoring tst basd on prfrntial hypracuity primtry vrsus standard clinical monitoring procdurs in dtcting th ncssity of rptition of intravitral tratmnt with anti angiognic drugs for patints affctd by novascular ag rlatd Emilia Romagna PARMEGGIAN I FRANCESCO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Linking purinrgic P2X7 rcptor to inflammation in Multipl Sclrosis: a novl targt for thrapy. SANTA LUCIA Amadio Susanna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Cockayn syndrom: targting mitochondrial dysfunction as a novl thraputic approach to prvnt nurodgnration Istituto Suprior di Sanita' D'Errico Mariarosaria Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND MICRORNA IN PAPILLARY THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Borrllo Maria Grazia Biomdica Oncology 1 Basic Tumor Cll Biology TCB Idntification of novl biomarkrs for th chckpoint inhibitor tratmnt of mlanoma patints I. O. V. Mandruzzato Susanna Clinicoassistnzial Oncology 2 Cancr Biomarkrs Evaluation of biological proprtis and in vivo prsistnc of human mmory lik Natural Killr clls as a tool for a novl approach of antitumor cll thrapy in pdiatric patints with high risk solid tumors givn ithr autologous or allognic hmat SAN MATTEO MACCARIO RITA Clinicoassistnzial Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 190 di 356

191 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exploiting th p53 pathway: Molcular mchanisms of th incrasing risk of brast cancr associatd with aging I.E.O. MIGLIACCIO ENRICA Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Validation of th histon dmthylas LSD1 as a targt in acut myloid lukmia I.E.O. MINUCCI SAVERIO Biomdica Oncology 1 Basic Molcular Oncognsis MONC Hpatitis B Vaccination in HIV Positiv Adults with Isolatd Antibodis to HBV Cor Antign (Anti HBc): Evaluation of Humoral and Cllular Immun Rspons SAN RAFFAELE MILANO Morsica Giulia Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Gn xprssion profils in ovarian cancr. Focus on Sgk1 and rlatd molculs in th dvlopmnt of patint tailord thrapis. Th modulation of Sgk1 kinas activity by Sgk1 intracting pptids and small molculs forinnovativ thraputic approach Calabria Prrotti Nicola Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT A Multidisciplinary Magntic Rsonanc Imaging and Immunohistochmical study of human ftal malformation of cortical dvlopmnt. CARLO BESTA Frassoni Carolina Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Protin and microrna xprssion profils of multipl sclrosis patints in glatiramr actat tratmnt: potntial biomarkrs Puglia D Masi Robrto Biomdica Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT P2RX7, a gn modifir in ALS: gntic and functional analysis of polymorphisms in a cohort of ALS patints. SANTA LUCIA Volonté Cinzia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Innovativ thrapis for th rscu of intllctual disability in Down syndrom, a modl of gntic cognitiv dfct and Alzhimr's lik dmntia Campania Scala Iris Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD p73/hif 1alpha axis in physiological and pathological conditions ISTITUTO DERMOPATICO DELL'IMMACOLATA Mlino Grry Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 191 di 356

192 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv High throughput, population wid, rflx tsting of colorctal cancr: molcular charactrization, idntification of individualizd thrapy targts and prvntion of familial cass IRCCS AOU San Martino IST (Gnova) Mastracci Luca Clinicoassistnzial Oncology 2 Cancr Biomarkrs BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY BACTERIOVORAX SPECIES. IZSUM Ottaviani Donatlla Biomdica Vtrinary Food Safty FOSA Rol of Mditrranan Dit on brast cancr rcurrnc in postmnopausal womn Calabria Montalcini Tiziana Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP A comparativ study of polydoxyribonuclotid (PDRN) with hyprbaric oxygn (HBO) thrapy on th haling of chronic diabtic foot ulcrs. (THE POLYHBODFU study) Sicilia Altavilla Domnica Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Complmntary vaccination with dndritic clls pulsd with autologous tumor lysat in rsctd stag III and IV mlanoma patints: a phas II randomizd trial Istituto Scintifico Romagnolo ridolfi laura Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Prdiction of livr adnoma and carcinoma onst by assssmnt of mirna in th blood GASLINI Eva Alssandra Biomdica Gns, Gnoms and Gntics Gn Thrapy and Inborn Errors GTIE Spcial Emphasis Panl Hmorhological disordrs and diabts mllitus: th Progtto Diabt Calabria Study. Calabria Claudio Carallo Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Combining intgratd oxidativ protomic and mtabolism profils for th idntification of novl pathogntic mchanisms and thrapis against hyprtrophic cardiomiopathy and pigmntary rtinopathy in mitochondrial trifunctional protin dficincy/long ch OSPEDALE BAMBINO GESU' Pastor Anna Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 192 di 356

193 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Enhancd rcovry program in pancratic surgry. An innovativ approach to improv outcom and optimiz rsourcs. Lombardia GIANOTTI LUCA VITTORIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Calcium Calmodulin Kinass mdiatd rgulation of human athrosclrotic plaqus: rol in vascularwall and infiltrating inflammatory clls Campania Illario Maddalna Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR EXPRESSION PROFILING IN HUMAN HORMONE SECRETING NEUROENDOCRINE TUMORS IN ASSOCIATION WITH CLINICAL AND BIOCHEMICAL FEATURES AUXOLOGICO Pcori Giraldi Francsca Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Mtagnomic analysis of infctious agnts involvd in colon polyps and cancr as innovativ prvntion and tratmnt stratgis Istituto Suprior di Sanita' Di Bonito Paola Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Discovring mtabolomic signaturs associatd with spcific gn mutations in mlanoma and thir rol in tumor radiosnsitivity and immunognicity. Istituto Suprior di Sanita' Rainaldi Gabrilla Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Multidrug Rsistanc of th Blood Brain Barrir: clinical implications and pharmacological activity of anticancr agnts Toscana Sardi Iacopo Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Immun rsponss of man and animals to infctious and non infctious strssors: idntification of cross spcis host paramtrs of immunocomptnc IZSLER Amadori Massimo Biomdica Immunology Innat Immunity And Inflammation III Providing indication for novl thraputic stratgis and drugs to improv outcom of rcurrnt ostosarcoma patints RIZZOLI Srra Massimo Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Idntification of nw candidat Brugada Syndrom gns and advancd functional analysis in patint spcific inducd pluripotnt stm cll modls. SAN RAFFAELE MILANO Bndtti Sara Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 193 di 356

194 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt and Evaluation of Influnza Virus Polymras Inhibitors for Combination Antiviral Thrapy Istituto Suprior di Sanita' Puzlli Simona Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR A translational study of dysautonomia and othr nonmotor symptoms in parkinsonism NEUROMED Fornai Francsco Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration MOLECULAR AND IMMUNOLOGICAL PATHWAYS INVOLVED IN ONSET AND MALIGNANCY OF EXPERIMENTAL OSTEOSARCOMA AND HEMANGIOSARCOMA AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI Landuzzi Lorna Biomdica Oncology 1 Basic Tumor Cll Biology TCB Th mrging rol of micrornas in autism spctrum disordrs Associazion Oasi Maria SS Elia Maurizio Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Innovativ mthods for autologous pancratic bta clls and psudo islts production. MULTIMEDICA Biunno Ida Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO DEVELOPMENT OF INSULIN PRODUCING BIOHYBRID ORGAN FOR THE CURE OF TYPE I DIABETES Umbria Calafior Riccardo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Modulation of TIMELESS xprssion by mir 139.5p influncs cancr cll bhavior and incrass chmosnsitivity in colorctal cancr CASA SOLLIEVO SOFFERENZA Mazzoccoli Gianluigi Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Elvatd lvls of HbA1c in subjcts with normal glucos tolranc ar associatd with cardiovascular risk profil: rol of solubl Rcptor for Advancd Glycation Endproducts (srage). Sicilia Piro Salvator Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM1 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 194 di 356

195 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Multi pitop ERBB2 targting with humanizd antibodis REGINA ELENA Giacomini Patrizio Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Strngthning th public halth through th us of bivalv molluscs as indicators of nvironmntal contamination by human activity that affct food safty IZSUM Latini Mario Biomdica Vtrinary Food Safty FOSA NEUROPHYSIOLOGICAL AND OPTOGENETIC ASSESTMENT OF SYNAPTIC PLASTICITY IN DYT11 DYSTONIA SANTA LUCIA Martlla Giusppina Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt Of A Novl Adoptiv Cll Transfr Approach (ACT) For Cancr Immunothrapy Basd On Th Us Of Autologous IFN DC For Th Induction Of Anti Tumor Rspons And Implmntd By Stratgis Aimd At Extnding Th Rplicativ Lifspan Of Th Anti Tumo Istituto Suprior di Sanita' Santini Stfano Maria Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Nxt gnration squncing to uncovr novl markrs and thraputic targts for radioiodin rsistant papillary thyroid carcinoma ISTITUTO TUMORI MILANO Grco Maria Angla Biomdica Oncology 1 Basic Cancr Gntics CG PATHOGENIC CHARACTERIZATION OF AUTOSOMAL RECESSIVE SPASTIC ATAXIA OF CHARLEVOIX SAGUENAY TRHOUGH STUDIES IN VITRO AND IN VIVO STELLA MARIS Tssa Alssandra Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Ethical Counsling Srvic I.E.O. Boniolo Giovanni Clinicoassistnzial Halthcar Dlivry and Mthodologis Rsarch on Ethical Issus in Human Studis REHS Th ffct of physiologically rprsntativ complx contxt on Total Kn Rplacmnt war. Toward th intrprtation and th knowldg of tribological procsss in joint prosthss. RIZZOLI Affatato Maria Uldrico Biomdica Surgical Scincs, Savrio Biomdical Imaging, and Bionginring Small Businss Bionginring, Surgical Scincs, and Tchnology SBTS (SBIR/STTR) Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 195 di 356

196 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exosom mdiatd RNA intrfrnc: a nw thraputic stratgy for HPV inducd cancr Istituto Suprior di Sanita' Chiantor Maria Vincnza Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Gntic and antignic divrsity and pathognicity of viruss associatd with ntritis Emilia Romagna Mdici Maria Cristina Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F D2 rsction and HIPEC (hyprthrmic intrapritonal chmoprfusion) in locally advancd gastric carcinoma: a randomizd and multicntric phas III study. SAN RAFFAELE MILANO Orsnigo Elna Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Novl pathways to chmorsistanc in chronic lymphocytic lukmia: study of Toll lik rcptors signaling molculs. SAN RAFFAELE MILANO Muzio Marta F Biomdica Immunology Innat Immunity And Inflammation III Targting strss rspons pathways in human mlanoma ISTITUTO TUMORI MILANO Anichini Andra Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Rol of HMGB1 in Doxorubicin inducd cardiotoxicity MONZINO Milano Giusppina Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF A NANOMEDICINE APPROACH FOR TRIPLE NEGATIVE BREAST CANCER (TNBC). TARGETING THROUGH INNOVATIVE NANOPARTICLE APTAMER BIOCONJUGATES. Toscana crispino srgio Biomdica Oncology 2 Dvlopmntal Thraputics DT Extracllular vsicls in th crosstalk btwn adipocyts and pancratic bta clls: link with obsity and diabts. Pimont Granata Riccarda Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Molcular, immunological and imaging dtrminants of outcom in sorafnib tratd patints with hpatocllular carcinoma Emilia Romagna Missal Gabril Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 196 di 356

197 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Quality of lif in spinal cord injury: mthods of masurmnts and corrlation with individual paramtrs MAUGERI Fizzotti Gabrilla Clinicoassistnzial Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Th bank vol as a novl animal modl for invstigating th prion lik proprtis of tauopathis. Istituto Suprior di Sanita' Di Bari Michl Anglo Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Gntic dissction of cystic fibrosis host suscptibility to Psudomonas aruginosa infctions using a highly gntically divrs mous rsourc population, th Collaborativ Cross mic SAN RAFFAELE MILANO Bragonzi Alssandra Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Dvlopmnt of nw tchnologis to promot thymic rgnration for th tratmnt of Primary Immunodficincis SAN RAFFAELE MILANO Bosticardo Marita Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Mitochondrial dysfunction and iron (dys) mtabolism in Nurodgnration with Brain Iron Accumulation (NBIA): an intgratd approach basd on human nuronal cllular systms CARLO BESTA Tiranti Valria Sonia Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN A nw potntial thraputic for Rtt Syndrom: a prclinical study Istituto Suprior di Sanita' Fiorntini Carla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Drug Discovry in th Nrvous Systm ZRG1 MNPS Systms data for individual rnal cancr mdicin ISTITUTO TUMORI MILANO Bongarzon Italia Clinicoassistnzial Oncology 2 Cancr Biomarkrs Molcular mchanisms and thraputic implications of alpha 7 nachr anti inflammatory pathways in th prvntion of obsity linkd co morbiditis AUXOLOGICO Cancllo Raffalla Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST Dndritic cll basd vaccin thrapy in msothlioma patints: prclinical and phas I clinical studis Istituto Suprior di Sanita' Proitti Enrico Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 197 di 356

198 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Caffin as a potntial thraputic option for Alzhimr's disas Istituto Suprior di Sanita' Popoli Patrizia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Tumor and immun clls cross talk in ostosarcoma: additional tratmnt opportunitis RIZZOLI Scotlandi Katia Biomdica Oncology 1 Basic Tumor Micronvironmnt TME A natural Aß variant with dominant ngativ ffct on amyloidognsis nginrd to tackl Alzhimr's disas CARLO BESTA Di Fd Giuspp Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt of a biotch systm for natural compound production, by plant in vitro tissucultur, for th prvntion and tratmnt of human dismtabolic disass. Istituto Suprior di Sanita' Loizzo Stfano Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP PARP inhibition as thraputic targt for Huntington's disas SANTA LUCIA Fusco Francsca Biomdica Brain Disordrs and Romana Nuroscinc Nuroscinc and Nurodgnration Nurons drivd from inducd pluripotnt stm clls from multipl sclrosis patints as a tool for studying pathognic disas mchanisms and idntifying novl nuroprotctiv compounds SAN RAFFAELE MILANO Martino Gianvito Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT dl oncolytic virus and innat immun rspons stimulation in Anaplastic Thyroid Carcinoma modls Campania Portlla Giuspp Biomdica Oncology 2 Dvlopmntal Thraputics DT Biological aging and urban pollution Vnto MAESTRELLI PIERO Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Sphingolipid inflammatory mdiators in Alzhimr disas pathognsis and sprad FATEBENEFRATELLI Bnussi Luisa Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 198 di 356

199 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nanoparticl dpndnt dlivry of stroids for th tratmnt of primary biliary cirrhosis to incras thir thraputic indx HUMANITAS INVERNIZZI PIETRO Biomdica Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Nonicotinoids and pyrthroids, an mrging halth issu for bs and humans IZSAM Scortichini Giampiro Biomdica Vtrinary Food Safty FOSA Pain in Parkinson's Disas. A multidisciplinary clinical, nurophysiological and transcranial brain stimulation approach. Vnto TINAZZI MICHELE Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dfining molcular targts that govrn th capacity of platlts to support hpatitis B virus (HBV) associatd livr immunopathology SAN RAFFAELE MILANO Guidotti Luca Biomdica Immunology Immunity and Host Dfns IHD Idiopathic Inflammatory Myopathis: idntification of a diagnostic pigntic biomarkr MYOMIRNA Emilia Romagna Cnacchi Giovanna Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO Cytokins and adipokins in phnotypd COPD as inflammatory biomarkrs in rlation to xtrapulmonary manifstations and dysmtabolism. Toscana Parronchi Paola Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Th P2X7/inflammasom axis: a ky playr in adipos tissu mtabolism in halth and disas. Toscana Solini Anna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD Dciphring TDP 43 proprtis in th Fronto Tmporal Dmntia/Amyotrophic Latral Sclrosis spctrum disordrs. SANTA LUCIA Longon Patrizia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 199 di 356

200 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ROLE OF THE NOVEL PROTEIN DEPDC5 IN NEURONAL PHYSIOLOGY AND PATHOGENESIS OF FAMILIAL FOCAL EPILEPSIES: POTENTIAL THERAPEUTIC IMPLICATIONS. Istituto Scinz Nurologich Bisulli Francsca Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration PINOCCHIO: computd aidd Planning and monitoring biological bon rconstructions in CHIldrn Oncology. RIZZOLI Taddi Fulvia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM MECHANISMS GOVERNING THE PERITONEAL DISSEMINATION AND THE CHEMORESISTANCE OF THE EPITHELIAL OVARIAN CANCER ISTITUTO TUMORI MILANO Tomasstti Antonlla Biomdica Oncology 1 Basic Tumor Cll Biology TCB NEW STRATEGIES FOR MUCOSAL VACCINATION AGAINST HELICOBACTER PYLORI AND CLOSTRIDIUM DIFFICILE INFECTIONS Toscana GHELARDI EMILIA Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F INSIDE: INtgratd in SIlico and in vivo approach to uncovr th hiddn gntic basis of GnRH nuron DEficincy AUXOLOGICO Bonomi Marco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER An intgratd approach to unravl th gntic causs and molcular pathognsis of pilptognic focal cortical dysplasia. Toscana Gurrini Rnzo Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Validation of pharmacogntic nhancmnt of Ras ERK signalling to prvnt nurodgnration and cognitiv dficits in mous modls of Parkinson's Disas. SAN RAFFAELE MILANO Fasano Stfania Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Anti Cholinrgic rcptors antibodis, cardiovascular autonomic profil and dysautonomia symptoms rlationships in Pur Autonomic Failur, Amyotrophic Latral Sclrosis and Postural Orthostatic Tachycardia Syndrom: vidnc for a pathophysiology basd th HUMANITAS Furlan Raffallo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 200 di 356

201 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Can w idntify th structural and gntic traits of bonimpairing dismtabolisms? A pilot study in Ostognsis Imprfcta and Klinfltr Syndrom patints. RIZZOLI Baruffaldi Fabio Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Dvlopmnt and Disas SBDD How to fac th mrgnc of multidrug rsistant carbapnmass producing Klbsilla pnumonia strains causing bactrmia/spticmia. Toscana Luptti Antonlla Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR A nw modl to valuat surgical radmission rats as hospitals' quality of car indicator Sicilia Vital Francsco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Insulin Rsistanc, Inflammation and Cardiovascular Risk: Molcular Bass, Pathophysiological, and Thraputic Implications of th High Mobility Group Protin AT Hook 1 (HMGA1) Calabria BRUNETTI ANTONIO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Cardiac amyloidosis: molcular mchanism and innovativ thrapis for a challnging aging rlatd cardiomyopathy SAN MATTEO MERLINI GIAMPAOLO Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function B MSFB SELECTIVE AXILLARY LYMPH NODE DISSECTION VS COMPLETE AXILLARY DISSECTION: A RANDOMISED CLINICAL TRIAL TO ASSESS THE PREVENTION OF LYMPHEDEMA IN BREAST CANCER TREATMENT ISTITUTO TUMORI MILANO Gnnaro Massimiliano Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Can dit and mtabolic factors affct fficacy and toxicity of chmothrapy in cancr patints? Sicilia Frittitta Lucia Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP Rgulation of SMN2 splicing in cll and mous modls of Spinal Muscular Atrophy SANTA LUCIA Stt Claudio Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 201 di 356

202 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Computr aidd diagnosis of brain amyloidosis in PET imaging. Implmntation of th automatic, SUVRindpndnt scoring systm for EvaLuation of Brain Amyloidosis (ELBA) in two groups of subjcts, having maximum (i.., patints with crtifid Alzhimr's IRCCS AOU San Martino IST (Gnova) Nobili Flavio Mariano Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A multidisciplinary approach to optimiz th clinical managmnt of patints and mak it rady to th nw diagnostic and thraputic opportunitis. Th cas of arrhythmognic inhritd disass. Pimont Giusttto Carla Clinicoassistnzial Cardiovascular and Rspiratory Scincs Elctrical Signaling, Ion Transport, and Arrhythmias ESTA Endocrin valuation in patints with traumatic brain injury. Study corrlation btwn ndocrin paramtrs, body composition, and nurocognitiv, nurobhavioral and quality of lif aspcts SDN Di Somma Carolina Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER Mmbran composition and dynamics in Plasmodiuminfctd rythrocyts: nw approachs for malaria control Istituto Suprior di Sanita' Ponzi Marta Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE An innovativ and affordabl nxt gnration squncingbasd stratgy for th diagnosis of drug rsistant tubrculosis and thrapy follow up. SAN RAFFAELE MILANO Cirillo Danila Maria Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS IMPLEMENTATION OF LIVER CIRRHOSIS DIAGNOSIS AND DEVELOPMENT OF A TELEMEDICINE PROJECT FOR TERRITORIAL MANAGEMENT Vnto Patrizia Pontisso Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG ATP P2X7R immunity promots brakdown of tolranc in typ 1 diabts Lombardia Zuccotti Gian Vincnzo Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Thraputic targts in Chronic Lymphocytic Lukmia (CLL): a study basd on micronvironmnt and lukmic B clls cross talk. IRCCS AOU San Martino IST (Gnova) Cutrona Giovanna Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 202 di 356

203 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Validation of th Long ncrna TRPM2 AS as a Novl Prognostic Markr and Thraputic Targt in Prostat Cancr Patints with Plvic Lymph Nod Invasion SAN RAFFAELE MILANO Lavorgna Giovanni Biomdica Oncology 1 Basic Tumor Cll Biology TCB Nurobiological Mchanisms Undrlying Effctivnss of Cognitiv Bhaviour Tratmnt in childhood and adolscnc Anxity Disordrs MEDEA Nobil Maria Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Circulating microrna signaturs for glioblastoma multiform Vnto Dchcchi Maria Cristina Biomdica Oncology 2 Cancr Biomarkrs Rol of 'non classical' rnin angiotnsin systm in th progrssion of diabtic nphropathy in a rat modl of typ 1 diabts. SAN MATTEO ZONTA SANDRO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Efficacy of Albumin Rplacmnt and Balancd Solution in Patints with Sptic Shock (th ALBIOSS BALANCED trial): a 2 by 2 factorial, invstigator initiatd, opn labl, multicntr, randomizd, controlld trial. MAGGIORE Caironi Pitro Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Diabts Ktoacidosis in childrn and adolscnts: an Italian nationwid study on clinical, social and conomic impact March chrubini valntino Clinicoassistnzial Population Scincs and Epidmiology Kidny, Nutrition, Obsity and Diabts KNOD Brain mitochondrial dysfunction, abnormal thrmodynamics and inflammation in Parkinson's disas: invstigation of thr intrrlatd putativ causs MAGGIORE rango mario Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Analysis of plasma and urinary xtracllular vsicls in kidny transplant rcipints for th dtction and monitoring of immunologic and infctious complications Pimont Biancon Luigi Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Rab39b mous modls: pr clinical studis by using AMPA rcptors as possibl thraputic targts to unravl th rol of RAB39B in Intllctual Disability and Autism Spctrum Disordr SAN RAFFAELE MILANO D'Adamo Patrizia Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 203 di 356

204 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Innovativ stratgis to harnss th immun systm against cancr with bispcific antibodis Lombardia Golay Jos Thrs Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Altration of lipoprotins in HIV infctd patints: implications for cardiovascular disas. SPALLANZANI Alonzi Tonino Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP BRADEION AS A URINARY MARKER OF TRANSITIONAL CELL CANCER OF THE BLADDER: VALIDATION BY RT PCR OF SEPT4 TRANSCRIPTS AND DEVELOPMENT OF A DIAGNOSTIC TEST Sicilia BONGIOVAN LUCA Biomdica Oncology 2 NI Cancr Biomarkrs Innovativ biotchnologis for th assssmnt of Excssiv Physical Activity (EPA), hart rat variability and strss lvls in arly adolscnts with anorxia nrvosa rstrictiv subtyp (ANR) STELLA MARIS Mastro Sandra Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Association btwn intstinal microbiom and cardiornal syndrom in chronic hart failur patints Puglia Iacovillo Massimo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Protin aggrgation and dysrgulation of RNA mtabolism in FET modl of ALS SANTA LUCIA PARONETTO MARIA PAOLA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND RELATIONSHIP BETWEEN OBESITY, DIABETES MELLITUS, DYSLIPIDEMIA AND CARDIOVASCULAR DISEASES Toscana Di Bllo Vitantonio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF P2X ionotropic rcptors as thraputic targts in dystrophin and sarcoglycan dficint muscular dystrophis GASLINI Bruno Claudio Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 204 di 356

205 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dndritic clls basd immun tratmnt in HIV 1 infctd patints from th Intrnational Consortium of DC Vaccin: whol gnom and functional xprssion analyss BURLO GAROFALO CROVELLA SERGIO Biomdica AIDS and Rlatd Rsarch HIV/AIDS Vaccins VACC Changs in post transcriptional gn rgulation in ALSdu to xpansion of th c9orf72 rpats SANTA LUCIA Carrì Maria Trsa Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Th rol of Cardiac Ankyrin Rpat Protin in cardiac inflammatory pathways and rmodling associatd with human dilatd, hyprtrophic, and post inflammatory cardiomyopathy. HUMANITAS Bang Mari Louis Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Gut kidny axis: Rnal ffct of Mditrranan Dit and of Low protin Dit with Ktoacids to rstor th physiological intstinal microbiota in Chronic Kidny Disas (CKD) Campania Di Iorio Biagio Raffal Biomdica Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU mirna basd thraputics to targt protumorignic potntial of stromal fibroblasts in lung cancr ISTITUTO TUMORI MILANO Roz Luca Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Computr Assistd Evaluation of Fractur Risk in Tumor Spin Lsions RIZZOLI Schilo Enrico Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM QUANTIFICATION OF IGF 1 ISOFORMS AND ANALYSIS OF THEIR FUNCTION IN BREAST CANCER ISTITUTO TUMORI MILANO Villarini Anna Biomdica Oncology 2 Cancr Biomarkrs Chronic kindy disas, Artrial Stiffnss and Targt blood prssur (Th CAST Study) MAGGIORE Mazza Robrto Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 205 di 356

206 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Us of Fluorin 18 fluorodoxyglucos (18F FDG) positron mission tomography (PET) scan in guiding tratmnt and dtrmining prognosis in pulmonary sarcoidosis SAN RAFFAELE MILANO Crmona Gorg Ian Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Priphral nrvous systm involvmnt and nuropathic pain in immunoglobulin light chain (AL) amyloidosis: pidmiology and idntification of novl "omic" markrs for diagnosis, outcom prdiction and rspons assssmnt SAN MATTEO Palladini Giovanni Clinicoassistnzial Oncology 2 Cancr Biomarkrs Gntics of tast prcption, lif styl, halth status and colorctal cancr risk. Pimont Polizzi Salvator Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Approach to patints with shock du to systmic capillary lak syndrom (Clarkson Disas) admittd to mrgncy dpartmnts of Rgion Lombardia and idntification of th mchanisms lading to th incras in ndothlial prmability rsponsibl for th Lombardia Cicardi Marco Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Musculoskltal, Oral, and Skin Systms PPMO EVA: Early Vascular Abnormalitis in IUGRPrnatal and postnatal dtction of cardiovascular disordrs in intrautrin growth rstrictd ftuss and nonats: a multicntric clinical and biochmical study Vnto Cosmi Erich Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Diffrntiation and Dvlopmnt CDD Molcular taxonomy of (familial) spinal Sicilia Magro Gatano Biomdica Gns, Gnoms and Giuspp Gntics Gnomics, Computational Biology and Tchnology GCAT Establishing a platform for th translatomic analysis of ALS/FTD pathognsis and disas progrssion in transgnic modls SAN RAFFAELE MILANO Consalz Giangiacomo Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Hart rmodlling and xrcis tolranc in chronic obstructiv pulmonary disas rlatd to diffrnt phnotyps of th disas Emilia Romagna Plà Giovanna Maria Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 206 di 356

207 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Intrplay btwn th dcidual micronvironmnt and HLA G xprssing rgulatory clls in promoting tolranc at th ftal matrnal intrfac. SAN RAFFAELE MILANO Grgori Silvia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Patint Spcific Inducd Pluripotnt Stm Clls for Amyotrophic Latral Sclrosis drug scrning Pimont Mazzini Ltizia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Immunomdiatd mchanisms of disas progrssion in multipl myloma Puglia Ria Robrto Clinicoassistnzial Oncology 1 Basic Tumor Micronvironmnt TME Long trm prognosis and mortality fiftn aftr acut coronary syndrom: th ABC* study on acut coronary syndrom (*ABC is acronym for Adria, Bassano, Congliano, and Padova Hospitals): malignancis, strok, gndr prognostic diffrnc. Vnto brton giuspp Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Molcular bass for prsonalizd mdicin in psoriatic patints: analysis of xprssion and function of th PSORS1 locus gn CCHCR1 ISTITUTO DERMOPATICO DELL'IMMACOLATA Cavani Andra Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Prognostic valu of EndoPrdict (EP) scor in prmnopausal womn with nwly diagnosd ndocrinrsponsiv brast cancrs tratd with hormonal thrapy in th IBCSG (Intrnational Brast Cancr Study Group) SOFT and TEXT trials. I.E.O. Munzon Elisabtta Clinicoassistnzial Oncology 2 Cancr Biomarkrs Addrssing th rol of RPF 1 dvlopmntal factor in th pigntic landscap of Wilms tumor and Nuroblastoma pdiatric cancrs ISTITUTO TUMORI MILANO fiorino antonio Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Th long pntraxin PTX3 in cancr: a novl playr in cancr rlatd inflammation HUMANITAS Garlanda Ccilia Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 207 di 356

208 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th Nural Bass of Impaird Facial Emotion Rcognition in Bordrlin Prsonality Disordr Emilia Romagna D Panfilis Chiara Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Advancd thrapis in Parkinson s disas. and nurophysiological ffcts of continuous duodnal/jjunal lvodopa/carbidopa pump infusion and dp brain stimulation of th subthalamic nuclus (STN) NEUROMED Fabbrini Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Idntificazion di sistmi di rilascio ottimali pr i Nuclic Acid Basd Drugs studio di mccanismi di azion in alcuni modlli di patologi uman infiammatori /Idntification of optimal dlivry systms for th Nuclic Acid Basd Drugs and study of t Campania Piazza Ornlla Clinicoassistnzial Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Nw biomarkrs to prdict prognosis and tailor systmic thrapy in patints with Psudomyxoma Pritoni ISTITUTO TUMORI MILANO Draco Marcllo Clinicoassistnzial Oncology 2 Oncology CONC Dynamic tracing of th impact of nutralising and inhibitory non nutralising antibodis on HIV 1 infction of dndritic clls and macrophags at mucosal sits. SAN RAFFAELE MILANO Scarlatti Gabrilla Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Uncoupling protin 2 and incrasd strok suscptibility in strok pron spontanously hyprtnsiv rat. Rlvanc for th human disas. NEUROMED Rubattu Spranza Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Novl molcular and cllular pathophysiological mchanisms of diabtic vascular disas Abruzzo D Catrina Raffal Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Intstinal microbiom biomarkrs for non cliac glutn snsitivity: nw diagnostic and thraputic targts. Emilia Romagna DE GIORGIO ROBERTO Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 208 di 356

209 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Global Rar Tumor Ntworking and nw staging/prognostic concpts in Thymic Epithlial Tumors and in Non Small Cll Lung Carcinomas mtastatic to th Mdiastinum: an intgratd clinicopathological and molcular study REGINA ELENA Marino Mirlla Clinicoassistnzial Oncology 2 Cancr Biomarkrs Innat immunity in HIV patints who do not rcovr th immun systm aftr succssful antirtroviral thrapy: th rol of th inflammasom. Emilia Romagna Mussini Cristina Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Gastrointstinal Tract Prmability and Inflammation in HIV Infctd patints with mild to modrat Chronic Kidny Disas: a cross ovr, doubl blind, randomizd clinical trial Emilia Romagna Guaraldi Giovanni Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES IN PATIENTS WITH ALCOHOLIC AND DYSMETABOLIC CIRRHOSIS AND ALCOHOL CONSUMPTION Emilia Romagna Brnardi Mauro Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP bdsid to bnch invstigation of th cardiac advrs ffcts of protasom inhibition: obsrvational study in multipl myloma patints, and molcular invstigation in xprimntal modls of protasom failur dpndnt cardiomyopathy. Vnto Piazza Francsco Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Postural sway and facial mimicry as bhavioral markrs of covrt motor symptoms in Parkinson's disas in a nw diffrntial arly diagnostic protocol. SANTA LUCIA Pavon Ena Francsco Biomdica Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Brain Dvlopmnt in Childrn Born Prtrm: an fmri, Psychological and Nurological Follow up at Scholar Ag SAN RAFFAELE MILANO Scifo Paola Vittoria Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Mtal on mtal hip prosthsis: Cobalt inducd nurotoxicity RIZZOLI Toni Aldo Clinicoassistnzial Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 209 di 356

210 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv DC vaccination combind with radiothrapy and/or prmptiv IFN alpha in mlanoma: a phas II clinical study Istituto Scintifico Romagnolo Guidoboni Massimo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII ExoND Cross disas idntification and analysis of xosomal cargo signatur: implication for nuroprotction and thraputics in nurodgnrativ disass. MONDINO Fuzzati Mari Thérs Biomdica Brain Disordrs and Armntro Nuroscinc Cll Dath in Nurodgnration CDIN Cross talk btwn stromal clls, inflammation and ractiv oxygn spcis: Thir impact on cancr cll growth, survival, and cancr drug snsitivity SDN Laukkann Mikko Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Dvlopmnt and tsting of an activ, light wight, warabl lowr limb xosklton for gait assistanc in oldr prsons. DON GNOCCHI Molino Lova Raffal Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Prnylcystin Lyas as a potntial novl playr in athrosclrosis Hxabromocyclodcans (HBCDDs) and Novl Brominatd Flam Rtardants (NBFRs): food lvls, nvironmntal contamination and toxicological ffcts. MONZINO Banfi Cristina Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS IZSUM Pirsanti Arianna Biomdica Vtrinary Food Safty FOSA Improvmnt of gliomas diagnosis and tratmnt: gnomic altration, imaging charactristic and circulating mirna studis REGINA ELENA Vidiri Antonllo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Rol of angiotnsin convrting nzyms inhibitors on cardioprotction against anticancr thrapy inducd cardiotoxicity: in vivo clinical vidncs along with in vitro studis I.E.O. CARDINALE DANIELA MARIA Clinicoassistnzial Oncology 2 Oncology CONC HAART and prgnancy: cllular/tissu impact analysis in prgnant womn and utro xposd nwborn, and idntification of nw strss rlatd biomarkr SPALLANZANI Corazzari Marco Biomdica AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 210 di 356

211 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prsonalizd multidisciplinary thrapy in had and nck cancr basd on clinical and molcular markrs C.R.O. AVIANO Franchin Giovanni Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM MESENCHYMAL STROMAL CELLS BEHAVIOR IN DIFFERENT JOINT ENVIROMENTS TO DEVELOP POTENCY ASSAYS STRATEGIC FOR CLINICAL APPLICATION IN RHEUMATIC DISEASES RIZZOLI Lisignoli Gina Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Structur and Rgnration SBSR Rol of GALNT2 on insulin rsistanc and glucos homostasis CASA SOLLIEVO SOFFERENZA Di Paola Rosa Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Thraputic xploitation of corrlats of mlanoma cll rsistanc to targtd drugs through immunobiologic approachs C.R.O. AVIANO Sigalotti Luca Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT NEW THERAPEUTIC STRATEGIES TO IMPROVE T CELL FUNCTION BY TARGETING CO INHIBITORY RECEPTORS BY SMALL SYNTHETIC BLOCKING COMPOUNDS IN CHRONIC VIRAL INFECTIONS Emilia Romagna PENNA AMALIA Biomdica Immunology Immunity and Host Dfns IHD ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION Emilia Romagna Fabbri Raffalla Clinicoassistnzial Oncology 2 Cancr Biomarkrs Sxual orintation as a social dtrminant of halth: nongntic prdictors, quality of lif, halth status, and burdn of slctd mntal and non mntal halth disordrs among young adults in Friuli Vnzia Giulia. Friuli Vnzia Giulia Valnt Francsca Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Rol of sirtuin 3 and its modulation in diabtic vascular disas: insights from clinical and prclinical approachs Vnto Avogaro Anglo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Analysis of EMT lik bhaviour of hmatopoitic clls xprssing th lukmognic fusion protin AML1/ETO. I.E.O. ALCALAY MYRIAM Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 211 di 356

212 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ROLE OF THE NEUROTROPHIN BDNF AND ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS MONZINO Barbiri Silvia Stlla Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Evnt basd modlling of Alzhimr's disas progrssion to assist clinicians in th arly diagnosis and prognosis on a singl patint scal SANTA LUCIA Giulitti Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Targting Endothlin 1/YAP signaling to circumvnt chmorsistanc in ovarian cancr REGINA ELENA Bagnato Anna Trsa Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT PI3Kgamma at th intrsction btwn hyprtnsion and immun systm. NEUROMED Maffi Anglo Biomdica Vascular and Hmatology Hyprtnsion and Microcirculation HM Toward a prnatal non invasiv diagnosis of Congnital Hart Disass (CHDs): idntification of arly plasmatic markrs (mirnas) Lazio GRAMMATIC PAOLA Biomdica Gns, Gnoms and O Gntics Thraputic Approachs to Gntic Disass TAG Ag rlatd Macular Dgnration: analysis of gn xprssion in th Rtina Pigmnt pithlium Choroid complx from human donors and validation of nwly idntifid gns in disasd patints. Vnto FERRARI STEFANO Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT From migrain to Mdication Ovrus: nvironmntal, clinical and molcular risk stratification for prdicting migrain progrssion and for planning of prvntion stratgis. Istituto Scinz Nurologich Cvoli Sabina Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Pathogntic rol of ndothlial clls in psoriasis: idntification of thraputic targts and prdictiv factors of co morbiditis ISTITUTO DERMOPATICO DELL'IMMACOLATA Failla Cristina Maria Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS A rtrospctiv pidmiological valuation of Multipl Sclrosis in Umbria Umbria Sarchilli Paola Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 212 di 356

213 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Androgn xcss, hormonal rcptors, aromatas and 5alfa rductas activity, in brast cancr growth and prognosis ISTITUTO TUMORI MILANO Vnturlli Elisabtta Biomdica Oncology 2 Cancr Biomarkrs Study of th ffct of intravnous immunoglobulin thrapy on T cll rprtoir in AChR positiv Myasthnia Gravis as a modl for prsonalizd mdicin Lazio Bartoccioni Emanula Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Anthropomtric, mtabolic, inflammatory and cntral hamodynamic paramtrs associatd to nwly diagnosd hyprtnsion, inadquatly controlld blood prssar and vascular aging in a larg sampl of gnral population: thraputic and prognostic implicati Emilia Romagna Borghi Claudio Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Rd orang juic daily consumption and human halth: a pilot study in high cardio mtabolic risk subjcts and Typ 2 Diabtic patints Istituto Suprior di Sanita' MASELLA ROBERTA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Nanoformulatd antirtroviral drug for HIV radication from sanctuary sits Idntification and valuation of non cliac glutn snsitivity by morphologic and functional magntic rsonanc imaging using dynamic contrast nhancd and diffusion wightd imaging mthods in comparison with a basic immunological study Lombardia CORSI FABIO Biomdica AIDS and Rlatd Rsarch AIDS Discovry and RUGGERO Dvlopmnt of Thraputics ADDT Lazio Masslli Gabril Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Idntification of signalling pathway activation profils in colorctal cancr stm clls by mass cytomtry and corrlation with snsitivity to pathway targting drugs. Istituto Suprior di Sanita' Biffoni Mauro Biomdica Oncology 1 Basic Tumor Cll Biology TCB Autoractiv mmory stm T clls gnration and xpansion post islt transplantation SAN RAFFAELE MILANO Monti Paolo Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 213 di 356

214 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv PREDICTIVE GENETIC ALTERATIONS IN OVARIAN CANCER (PREGIO) Emilia Romagna Turchtti Danila Biomdica Oncology 2 Cancr Biomarkrs Calcitonin oligomrs as a modl to study th amyloid nurotoxicity: th focal rol playd by lipid rafts in th prvntion and cur. Istituto Suprior di Sanita' Diociaiuti Marco Biomdica Biological Chmistry and Macromolcular Biophysics Biochmistry and Biophysics of Mmbrans BBM Optimization of cardiac stm cll rplicativ capacity in prclinical and clinical modls of ischmic cardiomyopathy. SAN RAFFAELE PISANA LIMANA FEDERICA Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Innovativ targtd thrapy for th tratmnt of B cll lukmia BURLO GAROFALO Zauli Giorgio Biomdica Oncology 2 Dvlopmntal Thraputics DT BONE, FATTY TISSUE AND CARDIOVASCULAR SYSTEM: STUDY OF INTERACTIONS AMONG THREE SYSTEMS IN OBESE CHILDREN Puglia Fainza Maria Flicia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Complications in spinal surgry ar too high. A prospctiv monitoring to rduc and avoid thm. RIZZOLI Barbanti Brodano Giovanni Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO PREDICTIVE SERUM EPIGENETICS IN HEAD AND NECK CANCER Pimont Mrlano Marco Biomdica Oncology 2 Cancr Biomarkrs Pharmacological targting of brain 5HT7 rcptor to rscu molcular, morphofunctional and bhavioral dficits in prclinical modls of Rtt Syndrom Istituto Suprior di Sanita' Laviola Giovanni Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD IDENTIFICATION OF GENETIC VARIANTS UNDERLYING BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS USING EXOME SEQUENCING AND CORRELATION TO THE CLINICAL PHENOTYPE SAN RAFFAELE MILANO Carrra Paola Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Study th rpurposd drug Auranofin to find nw low cost thraputic stratgy for cancr patints ngativ and positiv for HIV infction C.R.O. AVIANO Aldinucci Donatlla Biomdica Oncology 2 Dvlopmntal Thraputics DT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 214 di 356

215 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Inhibition of ndocannabinoids hydrolyzing nzyms as a nw thraputic targt for migraintratmnt: studis in animal modls and prliminary valuation in humans MONDINO Tassorlli Cristina Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dfining th Combinatorial Supprssion of human Glioblastoma Cancr stm lik clls (hgscs) by th nurognic nich ffctors Ephrins and BMPs. Improving hgscs nrichmnt and sking nw hgsc spcific rgulators and novl thraputic options. CASA SOLLIEVO SOFFERENZA Vscovi Anglo Luigi Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Tratmnt of Subsyndromal Dlirium and Long trm Cognitiv Dysfunction aftr Cardiac surgry. Prdictiv valu of Nurobiochmical Markrs of brain injury and Rsting Stat Functional Connctivity valuation Emilia Romagna vzzani antonlla Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Ghrlin as a nw cardiomtabolic risk biomarkr: from population and patint studis to tissu and cll biology in hart and skltal muscl. Friuli Vnzia Giulia Barazzoni Rocco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Impact of Diabts on th Rgnrativ Potntial of th Human Rnal Glomrulus. SAN RAFFAELE MILANO Zrbini Gianpaolo Clinicoassistnzial Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Pathological biominralization: nw insights in human bioapatit dposits in th calcific aortic valv and aortic wall in th prvntion of arly calcification Vnto Viscardi Francsca Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Innat immun rsponss in Multipl Sclrosis SANTA LUCIA BORSELLINO GIOVANNA Biomdica Immunology Innat Immunity And Inflammation III Non traditional biomarkrs of CKD associatd cardiovascular disas: potntial nw avnus for prvntion and thrapy. Campania Prna Alssandra Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 215 di 356

216 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS). MONDINO Crda Cristina Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND ErbB rcptors and TGF bta crosstalk in H.pylori rlatd in gastric disass: molcular signalling and thraputic opportunitis Abruzzo Innocnti Paolo Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Thraputic targting of cancr stm clls and idntification of biomarkrs prdictiv of drug rspons in lung cancrs Istituto Suprior di Sanita' Eramo Adriana Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT SCREENING FOR OSTEOPOROSIS AND FRACTURE RISK: TARGETING THE LINK BETWEEN CIRCULATING MONOCYTES AND BONE REMODELING RIZZOLI Fini Milna Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal, Oral and Skin Scincs Small Businss SEMO Pathognsis and control of ostomylitis in priprosthtic infctions. Innat immun dfns against biofilm and dsign of anti infctiv biomatrials RIZZOLI Arciola Carla Rnata Biomdica Infctious Disass and Microbiology Bactrial Pathognsis BACP Hydrogn Sulfid rol in th inflammatory rspons in Amyotrophic Latral Sclrosis SANTA LUCIA Spalloni Alida Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Rol of autophagy in growth, progrssion and ndothlial trans diffrntiation of nuroblastoma clls GASLINI Pzzolo Annalisa Biomdica Oncology 1 Basic Tumor Micronvironmnt TME HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? IZSPLV Acutis Pir Luigi Biomdica Vtrinary Animal Halth ANHE Analysis of th clinico pathological and prognostic valu of dfcts in transcriptional rgulation of ovarian cancr Lombardia Bignotti Eliana Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM2 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 216 di 356

217 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv APPLICATIONS OF X RAY FLUORESCENCE BASED TECHNIQUES AND ADVANCED IMAGING METHODS TO UNRAVEL CHANGES IN IRON METABOLISM AND METAL TOXICITY IN CHILDREN BURLO GAROFALO Pascolo Lorlla Biomdica Biological Chmistry and Macromolcular Biophysics Enabling Bioanalytical and Biophysical Tchnologis EBT Assssmnt of th risk for consumrs xposd to industrial, urban and agricultural nvironmntal contaminants driving from th illgal disposal of wasts within th Land of Fir (Campania Rgion) Istituto Suprior di Sanita' Frrara Fulvio Biomdica Vtrinary Food Safty FOSA ALS and FTD: changing paradigms in th gnotypphnotyp corrlation du to C9orf72 and othr gn charactrization AUXOLOGICO Silani Vincnzo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration THE IMPACT OF INTENSIVE TUBERCULOSIS CASE FINDING WITH MOLECULAR TESTS IN HIV INFECTED PATIENTS Istituto Suprior di Sanita' Giuliano Marina Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Protostasis modulation as a novl thraputic stratgy for cystic fibrosis. GASLINI Pdmont Nicoltta Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG A nw stratgy against nurodgnration: pharmacological modulation of th Ca2+ prmability of ionotropic glutamat rcptors NEUROMED Fucil Srgio Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Sodium calcium xchangr (NCX): a nw playr in nuronal dgnration occurring in Parkinson's Disas SDN Sirablla Rossana Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Phas 1 2 study of valproic acid combind with radiothrapy and chmothrapy in locally advancd nonsmall cll lung cancr (V LANCE study) PASCALE Morabito Alssandro Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 217 di 356

218 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv mtor inhibition and cardiovascular aging in chronic kidny disas Puglia Stallon Giovanni Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Pharmacological Targting of th nw GPR17 rcptor to prvnt advrs rmodling and hart failur in th ischmic hart MONZINO Sironi Luigi Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM METABOHEARTFAIL GRAPE mirnas IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN 7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON ISCHEMIC CHRONIC HEART FAILURE Toscana Liontti Vincnzo Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM An intgratd gnomic and protomic approach for cancr scrning and targtd thrapy in arly stag lung adnocarcinoma Abruzzo BUTTITTA FIAMMA Biomdica Oncology 2 Cancr Biomarkrs A markr basd approach to multimodal sophagal cancr tratmnt I. O. V. Scarpa Marco Biomdica Oncology 2 Cancr Biomarkrs Dvlopmnt of anti giardial drugs targting g intractions. Istituto Suprior di Sanita' Lall Marco Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR USING VIRTUAL REALITY AND ROBOTICS REHABILITATION INTERVENTION TO IMPROVE SOCIAL AND COGNITIVE ABILITY IN ADOLESCENTS AND CHILDREN WITH AUTISM Abruzzo Valnti Marco Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Instrumntal Larning of Antrior Insular Cortx Activity with Ral tim fmri in AutismSpctrum Disordrs. S.CAMILLO Caria Andra Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 218 di 356

219 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Validation of Nxt Gnration Squncing (NGS) basd Lysosomal Storag Disas Diagnostic Panls and Charactrisation of Novl Gn Variants by Functional Studis through Transint Gnration of Zbrafish Mutants GASLINI Filocamo Mirlla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD What maks a maltratd child bcom an adult drug abusr: uncovring nuroimaging/blood biomarkrs and dsigning rscu thraputic stratgis in prclinical modls SANTA LUCIA carola valria Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Mutational profil of HCV non structural rgions (NS3, NS5a and NS5b) associatd with dirct acting antivirals rsistanc in HIV/HCV coinfctd individuals naiv or non rspondr to dual (Pg intrfron plus ribavirin, P R) anti HCV tratmnt: possibl i SAN RAFFAELE MILANO Bagaglio Sabrina Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Exploiting Rho GTPas signaling: a novl thraputic avnu in th tratmnt of Fragil X Syndrom Istituto Suprior di Sanita' Diana Giovanni Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Human nural stm/prognitor clls drivd from inducd pluripotnt stm clls (hinscs) as a rnwabl sourc of transplantabl nurons and oligodndrocyts. SAN RAFFAELE MILANO Gritti Angla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurognsis and Cll Fat NCF Crvical cancr scrning in youngr womn. Pimont Ronco Guglilmo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Towards th dfinition of molcular altrations charactristic of indolnt prostat cancr: Implications for improvd slction of activ survillanc patints ISTITUTO TUMORI MILANO Valdagni Riccardo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Evaluation of nw approachs for prvntion and control of Lgionlla and othr watrborn pathogns through th analysis of microbiom of drinking watr systms. Istituto Suprior di Sanita' ricci maria luisa Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F13 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 219 di 356

220 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Chromosom 17 gn amplification hotspots as biomarkrs and thraputic targts for aggrssiv brast cancr. I.E.O. DI FIORE PIER PAOLO Biomdica Oncology 1 Basic Molcular Oncognsis MONC Cll fr DNA mthylatd squncs in coronary artry disas: rol as nw potntial pathophysiologic markrs SAN DONATO Corsi Massimiliano Biomdica Gns, Gnoms and Romanlli Marco Gntics Gntics of Halth and Disas GHD Circulating micrornas as biomarkrs for diagnosis and prognosis of hpatocllular and cholangiocllular carcinomas Emilia Romagna Gramantiri Laura Biomdica Oncology 2 Cancr Biomarkrs MULTICENTRIC RANDOMIZED PHASE II TRIAL OF TRANSORAL ROBOTIC SURGERY (TORS) FOLLOWED BY RISK BASED DEINTENSIFIED RADIOTHERAPY VERSUS DEINTENSIFIED CURATIVE RADIOCHEMOTHERAPY FOR T1 T2 WITH MINIMAL NODAL INVOLVMENT HPV POSITIVE OROPHARYNX CANCER I.E.O. altrio danila Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Otoacoustic missions as biomarkrs of possibl synrgistic intraction in inducing haring damag: an xprimntal study INAIL Sisto Rnata Biomdica Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME Targtd gnom diting in Rcombination activating gn (RAG) 1: prcis corrction of th gntic dfct in human SCID. HUMANITAS Villa Anna Biomdica Immunology Cllular and Molcular Immunology B CMIB Evaluation of changs of fcal microbioma in patints infctd/colonizd with Klbsilla pnumonia carbapnams producrs (KPC Kp) aftr th us of dcontamination protocols SPALLANZANI D'arzzo Silvia Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Pathogntic aspcts of bolavirus infction SPALLANZANI Di Caro Antonino Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 220 di 356

221 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Innovativ HDACi/IFN alpha basd combination thrapy in solid tumors Istituto Suprior di Sanita' Gabril Lucia Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT REGENERATIVE THERAPY OF OSTEOCHONDRAL LESIONS: FACTORS THAT INFLUENCE CELLULAR MEDICINE RIZZOLI Buda Robrto Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI CDKL5 RARE DISEASE: CHARACTERIZATION OF THE DISORDER AND DEVELOPMENT OF THERAPEUTIC STRATEGIES Istituto Scinz Nurologich Gobbi Giuspp Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD QUANTITATIVE MRI OF THE BRAIN AND SPINAL CORD FOR THE EVALUATION OF ADRENOMYELONEUROPATHY SEVERITY AND PROGRESSION SAN RAFFAELE MILANO Politi Lttrio Salvator Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Prvnting mntal rtardation in two intrmdiat mtabolism disass: a prclinical invstigation for nw thrapy SANTA LUCIA Puglisi Allgra Stfano Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Functional dissction of th bon marrow privilgd maturation nich of Plasmodium falciparum transmission stags in a humanizd mous modl Istituto Suprior di Sanita' Alano Pitro Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Establishmnt of an Italian cohort study of psoriasis and psoriatic arthritis basd on rcord linkag of rgional halthcar administrativ databass, and assssmnt of th risk of svr infctions, major cardiovascular vnts, and cancr, in patints tr Lombardia Naldi Luigi Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD Halthy Math S.CAMILLO Smnza Carlo Clinicoassistnzial Biobhavioral and Bhavioral Procsss Cognition and Prcption CP Us of mropnm in critically ill patints with gram ngativ infctions. A multicntr randomizd study. SAN RAFFAELE MILANO Colombo Srgio Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 221 di 356

222 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of th intraction btwn nurotnsin and mtabotropic glutamat rcptors at cllular lvl: possibl involvmnt in th dvlopmnt and xprssion of lvodopa inducd dyskinsia. SANTA LUCIA Guatto Ezia Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Idiopathic Normal Prssur Hydrocphalus (inph), parkinsonism and dmntia: improving th accuracy of diagnosis and th patint car to rvrs th symptomatology Nurodgnration, Phnotyps and Outcom Masurs MONDINO Pacchtti Claudio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Ciliognisis and sonic hdghog signaling in Nimann Pick typ C disas: possibl rol in disas pathognsis. Friuli Vnzia Giulia Dardis Andra Elna Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN PENETRATION OF METAL NANOPARTICLES THROUGH BIOLOGICAL MEMBRANES AND IMMUNOLOGICAL RESPONSE Friuli Vnzia Giulia Bovnzi Massimo Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Rol of mirna/mrna ntwork and msnchymal stromal clls in th pathognsis of th aortopathy associatd with bicuspid and tricuspid aortic valv and as arly biomarkrs Campania Cipollaro Marilna Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Linking mtagnomic and mtabolomics profiling of th human intstinal microbiota to gut immun altrations in autoimmun Typ 1 Diabts SAN RAFFAELE MILANO Falcon Marika Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Nxt gnration squncing in Nural Tub Dfcts: idntification of suscptibility gns in ordr to improv prvntion and gntic counsling GASLINI Capra Valria Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD EVALUATION OF STANDARD VIDEODERMATOSCOPY AND LOW COST VIDEOMICROSCOPES AS NON INVASIVE DIAGNOSTIC TOOLS FOR SCABIES AND OTHER SKIN ECTOPARASITOSES OF THE MIGRANTS: A COST EFFECTIVE ANALYSIS Sicilia Micali Giuspp Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 222 di 356

223 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Epigntic/somatic altrations and intr cllular nuclic acids transfr associatd with an impaird control of ndognous rtrotransposabl lmnts in brast cancr: a study to invstigat pathognic mchanisms, nw prognostic disas markrs and xpri I.N.R.C.A. Cardlli Maurizio Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Nw stratgis for prsonalizd diagnosis and tratmnt of nphrotic syndrom in childrn. Toscana Romagnani Paola Clinicoassistnzial Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Effcts of an ndoscopic tchniqu, th duodnal jjunal bypass linr, on body wight, glyco mtabolic control and som adipocytokins in typ 2 diabtic patints SAN MATTEO Drosa Giuspp Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Multicntr phas II clinical study of adoptiv immunothrapy with alloractiv NK clls as consolidation stratgy for ldrly acut myloid lukmia patints Emilia Romagna Curti Antonio Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII Th morphomtric study of nrv: supr rsolution Mosaicing analysis (PNS MoMa) SAN RAFFAELE MILANO Sanguigno Luigi Biomdica Bionginring Scincs and Tchnologis Biodata Managmnt and Analysis BDMA Modulation of SHP2's allostric rgulation as a novl stratgy to trat hmatologic malignancis and RASopathis Istituto Suprior di Sanita' Martinlli Simon Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Sr/Thr protin phosphatass as potntially druggabl biomarkrs to prdict trastuzumab thraputic rsponsivnss, and countract th dvlopmnt of rsistanc in brast cancr SAN RAFFAELE MILANO TACCHETTI CARLO Biomdica Oncology 1 Basic Tumor Cll Biology TCB Th us of classical conditioning with a tlmdicin approach for anomia rhabilitation in chronic aphasia: a clinical outcom rsarch SANTA LUCIA Carlsimo Giovanni Augusto Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 223 di 356

224 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Pr clinical and clinical (phas I) invstigation on th rol of umbilical cord wall drivd msnchymal stromal clls (UC MSC) to trat svr grad III/IV stroid rsistant acut graft vrsus host disas (GVHD) Lombardia introna martino Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII Glycosaminoglycans as critical playrs in inflammation and tissu damag during chronic lung infction by Psudomonas aruginosa: prognostic and thraputic implications for cystic fibrosis SAN RAFFAELE MILANO Cigana Cristina Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Antnatal human hart dvlopmnt Lombardia cuttin maria srna Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Diffrntiation and Dvlopmnt CDD Dvlopmnt of novl biomarkrs for th arly diagnosis of chronic antibody mdiatd rjction in rnal transplantation Vnto Zaza Gianluigi Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Outcoms and cost of car in diabtic subjcts ovr 70 yars old living in Rgion March (Italy): rsults from a rcord linkag analysis of administrativ and clinical data btwn 2008 and 2012 I.N.R.C.A. Rabini Rosa Anna Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Hippocampal msolimbic ntwork dysfunction: a vicious worsning loop of cognitiv dclin in Alzhimr's disas? A molcular, lctrophysiological and bhavioral invstigation on a murin modl SANTA LUCIA Brrtta Nicola Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T ERK5 and Hdghog pathways as novl targts for mlanoma tratmnt Toscana Stcca Barbara Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Targting of lysophosphatidic acid mdiatd autocrin/paracrin growth signal as novl thraputic approach for livr cancr DE BELLIS Mazzocca Antonio Biomdica Oncology 1 Basic Molcular Oncognsis MONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 224 di 356

225 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv FECAL MICROBIAL TRANSPLANTATION IN HIV INFECTED PATIENTS WITH SUB OPTIMAL IMMUNOLOGICAL RESPONSE UNDER ANTIRETROVIRAL THERAPY Lombardia BANDERA ALESSANDRA Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT CONTROLLED PHYSICAL ACTIVITY, WELLNESS EDUCATION AND ACTIVE AGINGA cohort study on cardiovascular and hmodynamic rsponss to physical activity in th ldrly. Lazio lgramant jacopo maria Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Prostat Cancr Survillanc: a nw stratgy to slct and monitor patints using rpatd PSA tst and Magntic Rsonanc Imaging Istituto Oncologico Candiolo Rgg Danil Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Digging dpr into molcular mchanisms of bcl 2 mdiatd rgulation of diffrnt functions in mlanoma REGINA ELENA Dl Bufalo Donatlla Biomdica Oncology 1 Basic Tumor Cll Biology TCB Insid th mchanism of immun disrgulation du to EBV infction in MS SANTA LUCIA Anglini Danila Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Exploring th molcular mchanisms of glioblastoma stm lik cll survival and diffrntiation to dsign novl thraputic stratgis: micrornas as potntial supportrs to tumor vascularization Istituto Suprior di Sanita' Ricci Vitiani Lucia Biomdica Oncology 1 Basic Tumor Cll Biology TCB Targting HMGB1 with BoxA in inflammation associatd cancr SAN RAFFAELE MILANO Bianchi Marco E. Biomdica Oncology 2 Dvlopmntal Thraputics DT Implmntation and sustainability of a systms mdicin approach in patints affctd by cardiovascular disas and dysmtabolic status. Toscana Gnsini Gian Franco Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 225 di 356

226 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv KILLER IMMUNOGLOBULIN LIKE RECEPTOR AND HUMAN ENDOGENOUS RETROVIRUS K (HERVK) AS TUMOR BIOMARKERS OF ONCOGENESIS AND RESPONSE TO TREATMENT IN ONCO HEMATOLOGY Sardgna LA NASA GIORGIO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Innovativ tsting of bon substitut bioavailability for oral surgry procdur. Istituto Suprior di Sanita' Bdini Rosslla Biomdica Musculoskltal, Oral and Skin Scincs Oral, Dntal and Craniofacial Scincs ODCS Non invasiv brain stimulation in rhabilitation of nurological and cognitiv dfcts in post strok patints. Sicilia firro brigida Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Non coding RNA Signaturs: Novl Biomarkrs for arly dtction of Colorctal Cancr CASA SOLLIEVO SOFFERENZA Pipoli Ada Biomdica Oncology 2 Cancr Biomarkrs EVALUATING AND RANKING PATIENT ORIENTED OUTCOME MEASURES IN BRAIN TUMOR PATIENTS WITH EVIDENCE BASED CRITERIA Vnto Talacchi Andra Clinicoassistnzial Oncology 2 Oncology CONC Dvlopmnt of an immunothraputic stratgy for an ffctiv thraputic HPV vaccin Istituto Suprior di Sanita' NEGRI DONATELLA Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Non mlanoma skin cancrs and inflammation: Rols of NF kb rgulatd Gadd45b gn Abruzzo Fargnoli Maria Conctta Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Attacking amyotrophic latral sclrosis from th priphry: will th immun systm hlp to win th battl? Istituto Suprior di Sanita' Potnza Rosa Luisa Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Prclinical and clinical study on Schizophrnia Bipolar Disordr Spctrum (SZ BPDs) and Frontotmporal Dmntia (FTD) shard gntic and nurobiological profil Vnto Prini Giulia Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 226 di 356

227 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv SEARCHING NEW DIAGNOSTIC/PROGNOSTIC MARKERS OF CANDIDEMIA Istituto Suprior di Sanita' Torosantucci Antonlla Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Th rol of Hdghog pathway in th crbllar functionality and rsilinc SANTA LUCIA Ptrosini Laura Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Rgulation, Larning and Ethology BRLE Gntic markrs in ldrly to stimat th risk for vascular disass by using th priphral artrial disas modl. Sicilia Signorlli Salvator Santo Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD OPA1 rlatd blindnss in Italy: from gnotyp to phnotyp to disas modlling, towards a thrapy Istituto Scinz Nurologich Carlli Valrio Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration GASLINI Haupt Riccardo Childhood Cancr Survivors ntring adulthood: prvalnc of chronic conditions and th Survivorship Passport as a tool for transition to adult car and followup Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Italian Platform on Nurodgnrativ Disordrs of Aging. A Mta Databas of Italian Cohort studis SANTA LUCIA Musicco Massimo Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Nurobiology of Larning and Mmory LAM Srum Cholstrol fflux capacity (CEC) as an indx of plaqu vulnrability in patints with carotid athrosclrosis: corrlation with mbolic potntial valuatd by trans cranial Dopplr (TCD) Emilia Romagna Dnti Licia Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Modulating th dynamic molcular intrplay btwn carnosin lik pptids, mtal ions and abrrant ß amyloid pptids in CNS and in Alzhimr's Disas: intgratd modl approach for countracting nurodgnration SAN RAFFAELE MILANO Barca Amilcar Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 227 di 356

228 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Safty and ffctivnss of a nw xoskltal robotic dvic for hand motor rcovry aftr strok. Toscana Postraro Fdrico Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Protomic analysis of tars of patints with glaucomatous optic nuropathy: pointing towards th dvlopmnt of novl diagnostic, prognostic and thraputic stratgis for glaucoma BIETTI Oddon Francsco Clinicoassistnzial Brain Disordrs and Nuroscinc Antrior Ey Disas AED An addrssd nutrigntic approach to calcium nphrolithiasis SAN RAFFAELE MILANO Vzzoli Giuspp Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Epigntic marks and inflammatory profil of subcutanous adipos tissu in svrly obs subjcts bfor and aftr controlld caloric rstriction and xrcis training intrvntion. MAUGERI Rngo Franco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Dciphring th Systms Proprtis of th Mitochondrial Protom in Nurodgnrativ Disass SANTA LUCIA Urbani Andra Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nural Oxidativ Mtabolism and Dath NOMD Rlasing th immun braks to nhanc th powr of anticancr vaccins for th tratmnt of HER2+ cancr patints" Pimont SATOLLI MARIA Biomdica Oncology 2 ANTONIETTA Cancr Immunopathology and Immunothrapy CII Th functional basis of crbro crbllar connctivity: implications for dysfunction in Alzhimr disass MONDINO D'Anglo Egidio Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Nurobiology of Larning and Mmory LAM "Stand and Walk". Optimizing th mbodimnt and agncy of rlvant robotic walkrs in spinal cord injury patints SANTA LUCIA Pazzaglia Marilla Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 228 di 356

229 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv HIV 1 Env protins variability in variants from diffrnt HIV 1 subtyps and rcombinant forms and its corrlation with disas stag and rsistanc/snsitivity to nutralization. Istituto Suprior di Sanita' Butto Stfano Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP and molcular charactrization of corpus callosal abnormalitis: towards a bttr undrstanding of thir gntic basis. Campania Dl Giudic Ennio Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Adhrnc to Mditrranan Dit and prgnancy outcom: clinical, biochmical and pigntic ffcts. Campania Macchia Paolo Emidio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular, Molcular and Intgrativ Rproduction CMIR Assssing th rlvanc of a targt organ spcific mirna signatur in typ 1 diabts and in othr organ spcific autoimmun disass T cll rspons to anti TNF alpha thraputical agnts in tratd patints to prvnt loss of rspons and advrs drug ractions SAN RAFFAELE MILANO Battaglia Manula Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Toscana Maggi Enrico Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun GENOTYPE CHARACTERIZATION IN LIQUID BIOPSIES FOR THE EARLY IDENTIFICATION OF LETHAL DISEASE IN PROSTATE CANCER PATIENTS WITH PSA PROGRESSION AFTER PRIMARY TREATMENT Lombardia Brruti Alfrdo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Effcts of diffrnt ditary fatty acids on non alcoholic fatty livr disas in patints with typ 2 diabts Campania Riccardi Gabril Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Bioractor basd rcllularization of fixativ fr dcllularizd pricardium with aortic valv drivd intrstitial clls for drivation of living hart valv bioprosthss MONZINO Polvani Gianluca Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 229 di 356

230 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A multidisciplinary and intgratd study of th bhavioral, gntics and nurobiological corrlats of impulsiv and violnt bhavior. Implications for th dvlopmnt of rhabilitation stratgis in convictd offndrs. Toscana Pitrini Pitro Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Rfractory pilpsy or syncop incognito unmaskd by xhaustiv nurophysiologic and lctrocardiographic invstigations: a prospctiv, advancd diagnostic valuation that may allow an arly and altrnativ diagnosis in many patints with drug rsistant Calabria Gambardlla Antonio Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Botanicals usd in products marktd for human and animal halth: phytochmical profils and thir toxicity valuation Istituto Suprior di Sanita' GALLO FRANCESCA Biomdica Risk, Prvntion and ROMANA Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM W Nd TYME: th Italian "hub and spok" ntwork for cntralizd clinical and translational rsarch to nsur multidisciplinary xprtis and to promot drug dvlopmnt and biomarkr discovry for ThYmic MalignanciEs ISTITUTO TUMORI MILANO Garassino Marina Clinicoassistnzial Oncology 2 Oncology CONC DNA global dmthylation and spcific somatic mutation pattrns as potntial biomarkrs of risk for colorctal noplasm. Istituto Oncologico Candiolo Vnsio Tiziana Biomdica Oncology 2 Cancr Biomarkrs Effcts of snsory stimulation on cognitiv prformanc in normal subjcts and in brain injurd patints: an ERP analysis Toscana Carboncini Maria Chiara Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Gnotyp/phnotyp corrlation in rtinitis pigmntosa: us of multipl animal modls of photorcptors dgnration to lucidat molcular mchanisms of disas and rspons to diffrnt thrapis Lazio Falsini Bndtto Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 230 di 356

231 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of nvironmnt gn intraction in tiology and promotion of pituitary tumours. Sicilia Cannavò Salvator Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Cll typ and subunit spcific altrations of NMDA rcptors in striatum at arly stags of Parkinson's disas SANTA LUCIA Calabrsi Paolo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Oluropin aglycon fficacy against Alzhimr's disas: an advancd biological prclinical invstigation and a proof of concpt study in mild Alzhimr's disas patints Toscana SORBI SANDRO Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt of a nanoparticl basd pharmacological approach for amyotrophic latral sclrosis MARIO NEGRI Bigini Paolo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Novl srum biomarkrs of livr disas progrssion in obs patints with livr statosis Sicilia Montalto Giuspp Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD How is it possibl to dfin rhabilitation car appropriatnss? Th impact of an altrnativ valuation systm on th appropriatnss of halth car rsourcs Emilia Romagna Brianti Rodolfo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Exploring th phnotypic htrognity in E200K Crutzfldt Jakob disas by intgratd association studis: a modl for improving th managmnt of nurodgnrativ disass. Istituto Suprior di Sanita' Ladogana Anna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Silk protin platform for fficint mimicking of th bon marrow vascular nich and functional platlt production: a translational rsarch stratgy to undrstand platlt rlatd disass and prdict fficacy for candidat thraputics SAN MATTEO BALDUINI ALESSANDRA Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 231 di 356

232 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv P2X7 and cancr: a doubl dg sword GASLINI Marimpitri Danilo Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Evaluation of th vctor comptnc of mosquito spcis within th Culicina sub family for both circulating and importabl arboviruss, and assssmnt of th potntial xposur of animal and human populations to infctd vctors in North Eastrn Italy. Istituto Suprior di Sanita' Rzza Giovanni Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Rspiratory Syncytial Virus (RSV) infction in infants: th Ectont/IFNs axis as rgulator of inflammatory/adaptiv rsponss and as thraputic targt. Istituto Suprior di Sanita' Ausillo Clara Maria Biomdica Immunology Innat Immunity And Inflammation III Targtd Nxt gnration squncing: implmntation of a novl diagnostic tool in th clinical routin of nwborn scrning Emilia Romagna Simona Frrari Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Potntial rol of HDL Cholstrol Efflux Capacity in th valuation of cardiovascular risk in patints with Familial Hyprcholstrolmia (FH) IRCCS AOU San Martino IST (Gnova) pisciotta livia Biomdica Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS Influnc of mtallostrogns on risk of dvloping diffrnt brast cancr subtyps: an Italian cohort study ISTITUTO TUMORI MILANO Siri Sabina Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Multipl and inducibl gn thrapy for improving priphral nrv rgnration. Pimont Tos Pirluigi Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Padiatric Bipolar Disordr with comorbid Attntion Dficit / Hypractivity: nw priphral putativ biomarkrs and prclinical assssmnt of pharmacothrapy. Istituto Suprior di Sanita' Adriani Waltr Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Occupational skin disass: prvntiv masurs and individual suscptibility Friuli Vnzia Giulia Rui Francsca Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 232 di 356

233 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Killing rplicating and nonrplicating bacilli to fight tubrculosis Istituto Suprior di Sanita' Fattorini Lanfranco Biomdica Infctious Disass and Microbiology Small Businss: Non HIV Anti Infctiv Thraputics SBN Epidmiological mthodology of Salmonlla spp in Puglia isolatd from human and non human sourcs: isolation, idntification, drug rsistanc and clustr analysis. Puglia D Vito Danila Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS A gnom basd and functional approach to improv th diagnosis and dfin th molcular bass of syndromic and non syndromic intllctual disability. Pimont Brusco Alfrdo Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Gntic abnormalitis in C3 glomrulopathis and in immun complx associatd mmbranoprolifrativ glomrulonphritis MARIO NEGRI Noris Marina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Nw stratgis for thraputic and clinical car in human glioblastoma NEUROMED Arclla Antonitta Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Cyclophosphamid as sol graft vs. host disas prophylaxis in allognic hmatopoitic stm cll transplantation from HLA idntical donors: ffcts on transplant rlatd toxicity and graft vs. lukmia tumor/ffct. Pimont BRUNO BENEDETTO Clinicoassistnzial Oncology 2 Oncology CONC Dvlopmnt of diagnostic and prognostic pigntic tools for facioscapulohumral muscular dystrophy (FSHD) NEUROMED Dlla Ragion Floriana Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Effcts of continuous and intrmittnt hypoxia on Oncognsis Puglia lacdonia donato Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training Fllowship: Oncological Scincs F Dynamics of priphral blood molcular signaturs and circulating tumor clls to prdict rcurrnc in high risk tumor rsctd mlanoma patints Istituto Suprior di Sanita' Moschlla Fdrica Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 233 di 356

234 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exposur to chmicals, psticids and substancs of abus in prgnant womn: valuation of DNA damag and oxidativ strss paramtrs in priphral lymphocyts as biomarkrs of rproductiv risk Toscana MASINI EMANUELA Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Impact of prnatal xposur to nw anti HCV agnts on matrnal and nonatal outcoms. Istituto Suprior di Sanita' Floridia Marco Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Food Safty and Endocrin Disruptors: a) lvls of Bisphnols into cannd food and bvrags producd in Italy and b) dirct risk assssmnt for humans IZSME Gallo Pasqual Biomdica Vtrinary Food Safty FOSA Idntification of ncrnas as biomarkrs for arly dtction of aggrssiv prostat cancr in plasma and tissus Pimont zitlla andra Clinicoassistnzial Oncology 2 Cancr Biomarkrs N formyl pptid rcptors (FPRs) xprssion in Systmic Sclrosis substs a markr of fibrosis or vascular dysfunction? Campania d Paulis Amato Biomdica Immunology Innat Immunity And Inflammation III Mtabolic Risk Profiling for Prostat Cancr Managmnt Emilia Romagna Marchsini Giulio Clinicoassistnzial Rggiani Population Scincs and Epidmiology Epidmiology of Cancr EPIC Assssmnt and rmdiation of cognitiv functions and communicativ abilitis in traumatic brain injurd patints. Bhavioral improvmnt and crbral changs in functional brain connctivity. Pimont Carrara Giovanna Clinicoassistnzial Biobhavioral and Bhavioral Procsss Languag and Communication LCOM MRI nurography assssmnt of nrv rgnration du to tratmnt in injury, comprssiv and dgnrativ priphral nuropathis. SANTA LUCIA VADALA' RITA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T A novl TRAIL basd thraputic by Msnchymal clls TARgting PAncratic Cancr (TARPAC) Emilia Romagna Dominici Massimo Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 234 di 356

235 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Assssmnt of horizontal transfr of toxin and antibiotic rsistanc gns btwn pathognic clostridia and probiotic bactria. Istituto Suprior di Sanita' Franciosa Giovanna Biomdica Infctious Disass and Microbiology Topics in Bactrial Pathognsis Spcial Emphasis Panl ZRDM Dciphring th rol of th mtor pathway in th rgulation of ASCL1 inducd invasivnss of glioblastoma cancr stm clls SAN RAFFAELE MILANO Galli Rosslla Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Nxt gnration squncing tchniqus to idntify nw forms of inhritd thrombocytopnias and to chang th diagnostic approach to patints with low platlt count SAN MATTEO NORIS PATRIZIA Clinicoassistnzial Vascular and Hmatology Hmostasis and Thrombosis HT Nw ASIC channl inhibitors for th tratmnt of chronic nuro inflammation SAN RAFFAELE MILANO Muzio Luca Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Idntification of gntic profils associatd with IgE variability in bakrs xposd to occupational allrgns by xom squncing Vnto Oliviri Mario Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP Computr basd rhabilitation of communicativ disordrs in acquird crbral injury MAUGERI pistarini catrina Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Analysis of human pididymis protin 4 in pithlial ovarian cancr: biological rol and prdictiv significanc Lombardia Tognon Grmana Biomdica Oncology 2 Cancr Biomarkrs Invstigating pigntic pattrns inducd by diffrnt dits and food for cancr prvntiv halth nhancmnt I.E.O. LUZI LUCILLA Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Targtd glomrular dlivry of Brain Drivd Nurotrophic Factor (BDNF) to rpair podocyt cytosklton in protinuric disass. MAGGIORE Cllsi Francsco Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 235 di 356

236 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Physiothrapy and Ostoporosis: Idntification of clinical and biological markrs for th optimisation of th individualizd approach to rhabilitation Programs Sicilia Lio Domnico Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Dvlopmnt and Disas SBDD Rol of diaphragmatic ultrasonography in th diagnosis and prognosis in rspiratory valuation in patint with amyotrophic latral sclrosis (Eco.Di.SLA) Emilia Romagna Fantini Riccardo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Typ 4 Phosphodistrass as novl targts to rduc cardiovascular comorbiditis in COPD. Abruzzo Davì Giovanni Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR CYTOKINES, GROWTH FACTORS AND HEART RATE VARIABILY MARKERS OF JOB STRAIN. A PROPOSPECTIVE COLLABORATIVE STUDY. Friuli Vnzia Giulia Lars Filon Francsca Clinicoassistnzial Risk, Prvntion and Halth Bhavior Psychosocial Dvlopmnt, Risk, and Prvntion PDRP Microbiom assssmnt in th myocardial tissu of patints with dilatd cardiomyopathy andmyocarditis ngativ to th known cardiotropic viruss. SPALLANZANI Frustaci Andra Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Evidnc of a thraputic rol of NGF in multipl sclrosis: clinical and xprimntal studis. BIETTI Cntofanti Marco Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT TAVI vrsus Suturlss for th tratmnt of svr aortic stnosis in high risk patints: a multicntr prospctic randomizd study Emilia Romagna Ghrli Tiziano Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Rol of lipid signaling in Alzhimr s disas: idntification and modulation of survival molcular pathways to countract nurodgnration. SAN RAFFAELE PISANA CIRIOLO MARIA ROSA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 236 di 356

237 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Whol xom squncing and inducd Pluripotnt Stm Clls tchnology: nw tools to xplor th gntic causs of intllctual disability CASA SOLLIEVO SOFFERENZA Brnardini Laura Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Explor, Idntify and Validat prdictiv/prognostic biomarkrs for Diabtic Macular Edma: an onsit analysis. BIETTI Micra Alssandra Biomdica Cll Biology Biology and Disass of th Postrior Ey BDPE LONGITUDINAL MRI STUDY IN PRE MCI SUBJECT: IMAGING BIOMARKERS OF EARLY PRODROMAL NEURODEGENERATIVE CHANGES SANTA LUCIA GIUGNI ELISABETTA Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration and gntic charactrization of a rlvant cohort of Myasthnia gravis patints to prdict clinical pathways and dvlopmnt of tlconsultant activitis for rmot monitoring of th patint. Toscana Miglior Lucia Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD AUTOPHAGY IN PLASMA CELL ONTOGENESIS AND MALIGNANCY SAN RAFFAELE MILANO Cnci Simon Biomdica Immunology Cllular and Molcular Immunology B CMIB Nuroplasticity and Alzhimr's disas: intgratd approach to idntify biological and nurophysiological markrs. FATEBENEFRATELLI Miniussi Carlo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Subthalamic nuclus dp brain stimulation in Tourtt syndrom CARLO BESTA Albans Albrto Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration IN VITRO METABOLIC PROFILING OF EPITHELIAL OVARIAN CANCER CELLS AS A MARKER OF RESPONSE TO PLATINUM CHEMOTHERAPY I. O. V. Amadori Albrto Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 237 di 356

238 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A multidisciplinary approach that combins volutionary analysis, protin modlling, clinical and pidmiological gntics to clarify th pathognic mchanisms undrlying viral/bactrial ncphalitis. MEDEA Cagliani Rachl Biomdica Gns, Gnoms and Gntics Gntic Variation and Evolution GVE Ar gntic, inflammatory and mtabolomic markrs of coronary hart disas rlatd to kidny function dclin in patints with typ 2 diabts? CASA SOLLIEVO SOFFERENZA Mnzaghi Claudia Clinicoassistnzial Population Scincs and Epidmiology Kidny, Nutrition, Obsity and Diabts KNOD Impact on clinical car of th rorganization of tst for antiphospholipid antibodis in laboratory analysis. Friuli Vnzia Giulia fabris martina Clinicoassistnzial Vascular and Hmatology Hmostasis and Thrombosis HT Prclinical dvlopmnt of anticoagulant compounds, slctiv inhibitors of thrombin and activatd Factor X, as potntial antitumor stratgis in pancratic cancr Lombardia Falanga Anna Biomdica Oncology 1 Basic Tumor Cll Biology TCB Biological profil of monocyt drivd macrophags and its corrlation with plaqu morphology in ischmic hart disas MONZINO Marnzi Giancarlo Silvio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Cllular and animal modls of Panthothnat Kinas Associatd Nurodgnration (PKAN): from pathognsis to drug scrning. Lombardia FINAZZI DARIO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Rol of CD8+CD57+ T clls in rspons to Epstin Barr Virus and in Multipl Sclrosis SANTA LUCIA Cncioni Maria Trsa Biomdica Immunology Immunity and Host Dfns IHD Th molcular basis of th intrplay btwn lukotrin and purinrgic systms: nw thrapis in vascular inflammation Lombardia Cattano Marco Natal Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR IN VIVO EVALUATION OF THE ROLE OF METFORMIN IN THE TREATMENT OF ENDOMETRIAL CANCER Lazio Angioli Robrto Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 238 di 356

239 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Cord blood xpandd ndothlial prognitors in patints with untratabl critical limb ischmia: manufactur and validation of a dfinit allognic cll thrapy product, safty assssmnt in patints candidat to amputation and study of th immunological Lazio Tofili Luciana Clinicoassistnzial Vascular and Hmatology Vascular Biology Spcial Emphasis Panl SEVB Towards a prsonalizd tratmnt of mtastatic mlanoma: study on intrinsic rsistanc to MAPK inhibitors. I. O. V. Rossi Carlo Riccardo Clinicoassistnzial Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Prdiction of Cardiovascular Risk by Cardiopulmonary Exrcis Tsting: th EURO(pan) EX(rcis) Population Basd Study SAN DONATO guazzi marco Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Continuous car modl for ldrly patints who nd hospital rsourcs in th last yars of thir lif Lombardia scandiani luciana Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Evaluation of th immun rspons against Mycobactrium avium subsp. paratubrculosis (MAP) in humans and animals IZSUM Mazzon Pira Biomdica Immunology Immunity and Host Dfns IHD Mild cognitiv impairmnt and progrssion to Alzhimr's disas: association with hrps viruss infctions. Emilia Romagna Gabrilli Liliana Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration idntification of mutatd shp prion protin rsistnt to convrsion into PrPSc IZSUM Biagtti Massimo Biomdica Vtrinary Animal Halth ANHE Sarching for nw biomarkrs in Autism Spctrum Disordrs (ASDs) by DNA mthylation profil and gn xprssion analysis of ASD discordant sibpairs Vnto Dall Brnardo Biomdica Gns, Gnoms and Brnardina Gntics Gntics of Halth and Disas GHD Halth and halthcar for ldrly immigrants and minoritis in an italian ara with high immigration and aging indx: an intgratd approach basd on cultural comptncy and thnogriatric prsonalizd car Emilia Romagna colantoni alssandra Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 239 di 356

240 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nuron targting of nanoparticl conjugatd sirnas to corrct th mitochondrial phnotyp in nurological disass Campania NITSCH LUCIO Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Epigntic signatur of cardiomyocyts in modulating in th immun rspons of hart failur: a nw thraputic targt HUMANITAS PAPAIT ROBERTO Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Th purinrgic P2X7 rcptor on human cardiac fibroblast: a nw thraputic targt for advrs cardiac rmodlling in chronic hart failur? Toscana Laghi Pasini Franco Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF A randomizd controlld trial of a psychosocial INTERvntion on rlaps prvntion in patints in th first 5 yars from psychosis onst and thir rlativs in th VENEto rgion: fasibility, ffctivnss, prdictors of outcom and impact on Mntal Halt Vnto Ruggri Mirlla Clinicoassistnzial Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Novl multi analyt point of car tsting dvic for rapid diagnosis and managmnt of spsisand svr infction. Toscana Esin Smih Biomdica Intrdisciplinary Molcular Scincs and Training Small Businss: Dvics and Dtction Systms SBDS Modulation of microrna profils in modls of cliac disas by toxic and immunomodulatory gliadin pptids : potntial thraputic implication for cliac disas Istituto Suprior di Sanita' VINCENTINI OLIMPIA Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Rol of altrd prsynaptic protins mdiatd synaptic plasticity in cognitiv dclin in th aging brain I.N.R.C.A. Conti Fiornzo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Synapss, Cytosklton and Trafficking SYN Nw cll and rcptor suspcts in autoimmun typ 1 diabts SAN RAFFAELE MILANO Maugri Norma Biomdica Immunology Innat Immunity And Inflammation III Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 240 di 356

241 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv NON CONVENTIONAL PROGNOSTIC MARKERS AND THERAPEUTICAL TARGETS IN DEVELOPMENT AND PROGRESSION OF BLADDER CANCER SAN RAFFAELE MILANO Alfano Massimo Biomdica Oncology 2 Cancr Biomarkrs Short trm starvation as a stratgy to improv th fficacy of tyrosin kinas inhibitors in cancr GASLINI Raffaghllo Lizzia Biomdica Oncology 1 Basic Tumor Cll Biology TCB Rol of th Plasmodium Subtilisin lik protas Sub1 in gamt grss from th host rythrocyt. Istituto Suprior di Sanita' pac tomasino Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE MITOCHONDRIAL CALCIUM HOMEOSTASIS AND NEURODEGENERATION IN RODENT AND PRIMATE MODELS OF PARKINSON AND HUNGTINGTON DISEASE Vnto d'avlla domnico Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration D.Ha.R.P.: Ditary Habits, Nuclar Rcptors, and Pancratic Cancr Toscana Galli Andra Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Shdding nw light on wll diffrntiatd follicular drivd thyroid carcinoma: microfluidic thyroid on chip dvic as a tool for th idntification of novl diagnostic/prognostic biomarkrs toward a patintspcific tratmnt Lazio CRESCENZI Anna Biomdica Oncology 1 Basic Tumor Cll Biology TCB Novl computr basd motor rhabilitation and brain connctivity in Huntington's Disas SANTA LUCIA Di Paola Marghrita Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Sarch for Markrs of Damag in Hmatopoitic Clls in patints curd aftr childhood cancr GASLINI Frassoni Francsco Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Novl biomarkrs and thraputic targts for th human malignant plural msothlioma. Emilia Romagna Tognon Mauro Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 241 di 356

242 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A Twin Study on th Rlation btwn Psychological and Immunological Functioning Istituto Suprior di Sanita' Fagnani Corrado Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Cross disas Exprssion of Somatoform Phnotyps Epidmiology and Pathophysiology Abruzzo Onofrj Marco Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A multidisciplinary study for th discovry of nw clinical, mtabolomic and protomic markrs for th prdiction and dtction of gstational diabts Vnto Lapolla Annunziata Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Novl nanotchnology basd stratgis for diagnostic, thraputic and and clinical car in lymphoma. Toscana D'Elios Mario Milco Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training Small Businss: Biomatrials, Dlivry Systms, and Nanotchnology SBBD Pyrimthamin drivativs: a nw class of "low cost" antifolat drugs for tratmnt of mtastatic mlanoma. A prclinical study. Istituto Suprior di Sanita' Giammarioli Anna Maria Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Immunoprofiling as prdictiv biomarkr to slct patints candidat to b tratd with agnts modulating immun chck points ISTITUTO TUMORI MILANO DE BRAUD FILIPPO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Can multi paramtric Magntic Rsonanc Imaging (mp MRI) rduc ovrdiagnosis and ovrtratmnt in scrning for Prostat Cancr? An on arm pilot study in th Flornc ara. Toscana Zappa Marco Clinicoassistnzial Oncology 2 Cancr Biomarkrs Mditrranan plants for Human and a Sustainabl Livstock Halth car IZSSI Ral Stfano Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 242 di 356

243 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of priostin in th pathognsis and progrssion of ndomtriosis and ovarian cancr ndomtriosis rlatd. Calabria ZULLO FULVIO Clinicoassistnzial Oncology 1 Basic Molcular Oncognsis MONC Assssing th in vivo fficacy of pptid thraputics towards th progrssion of Amyotrophic Latral Sclrosis MAUGERI Rossi Danila Maria Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Cognitiv impairmnt in Nurodvlopmnt Disordrs and in arly onst Multipl Sclrosis: sarching for distinctiv/common pathognic insights and prdictiv biomarkrs of clinical cours Puglia Margari Lucia Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Inhibition of JNK PSD95 intraction: a novl stratgy to prvnt Alzhimr's disas MARIO NEGRI Borsllo Tiziana Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Nurobiology of Larning and Mmory LAM Epilpsy and suddn dath: Idntification and prvntion of rlativs using gntic diagnosis Lazio Oliva Antonio Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Effct of surgical or consrvativ approach in patints with adrnal incidntalomas on cardiovascular, mtabolic, nuropsychological and bon manifstations: rspctiv rols of cortisol scrtion and glucocorticoid snsitivity. MAGGIORE Chiodini Iacopo Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER Ostopnia and ostoporosis in HIV infctd patints: th rol of th virus and antirtroviral drugs. Emilia Romagna R Maria Carla Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Dtction of DNA mutations in urin of patints with prostat cancr for th idntification of arly prognostic biomarkrs Emilia Romagna Dll' Atti Lucio Biomdica Oncology 1 Basic Molcular Oncognsis MONC Assssmnt of botulinum toxin ffct on skltal muscl CARLO BESTA Zanotti Simona Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 243 di 356

244 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Tratmnt of joint dgnration: a nw stratgy for a nw tiopathology targt. A comparativ study on cll fr scaffold vs bon marrow concntrat for subchondral bon lsions. RIZZOLI Marcacci Maurilio Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Scrning for silnt atrial fibrillation in th ldrly: potntial for strok prvntion Umbria Bcattini Ccilia Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Myloid cll and adipocyt intraction in human bon marrow of frail ldrs: idntification of biomolcular markrs and thraputic targts of immun snscnc Vnto BRONTE VINCENZO Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Duchnn Muscular Dystrophy: a study of th natural history of rspiratory muscls assssd by nw noninvasiv diagnostic tchniqus MEDEA D'Anglo Maria Grazia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Impact of asbstos mdiatd inflammation in msothlioma gnsis and progrssion. Implication for arly diagnosis, prognosis and thrapy HUMANITAS SICA ANTONIO Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Nw Doxorubicin hpatic dlivry stratgy by ultrasound microbubbls and sonoporation, and ffcts of hm oxygnas 1 induction and inhibition, in th tratmnt of hpatocllular carcinoma (HCC) in rats: valuation of antinoplastic ffcts, prvntion o Vnto Sacrdoti David Biomdica Oncology 2 Dvlopmntal Thraputics DT Individual prdiction of urinary toxicity aftr radiothrapy of prostat cancr: incorporating clinical, dosimtric and gnomic/molcular paramtrs into prdictiv modls SAN RAFFAELE MILANO FIORINO CLAUDIO Biomdica Oncology 2 Radiation Thraputics and Biology RTB Effcts of Nuropptid Y on th cntral nrvous systm nurons of rat modls of Alzhimr Disas SANTA LUCIA Anglucci Francsco Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 244 di 356

245 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Impact of gndr and of rproductiv status on livr damag and cardiovascular dysfunction in patints with Nonalcoholic Fatty Livr Disas Pimont Vanni Estr Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP HEALTH OUTCOME AND MOLECULAR BASIS OF PRIMARY HYPOBETALIPOPROTEINEMIAS Emilia Romagna Lonardo Amdo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F Cardiac rmodlling in obs patints aftr diffrnt bariatric procdurs: novl tools in Cardiac Magntic Rsonanc and andslction of a novl clustr of cardiomtabolic biomarkrs. Lazio Carbon Iacopo Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI FIBRIN CLOT PROPERTIES, FIBRINOGEN OXIDATION AND OXIDATIVE STRESS IN ISCHEMIC STROKE: AN `IN VIVO' STUDY IN THE ACUTE PHASE AND AFTER INTRAVENOUS AND INTRA ARTERIAL Toscana Marcucci Rosslla Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Idntification of indpndnt biomarkrs prdicting aortic dissctions in patints with Marfan syndrom. AUXOLOGICO Salvi Paolo Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS DEVELOPMENT, VALIDATION AND CLINICAL APPLICATION OF NEXT GENERATION SEQUENCING MULTIGENIC PIPELINES FOR DETECTION AND DYNAMIC CHARACTERIZATION TOWARD PERSONALIZATION OF CANCER PREVENTION AND TREATMENT. Abruzzo Ricvuto Enrico Biomdica Oncology 2 Cancr Biomarkrs Study of th rol playd by S100B and RAGE in Amyotrophic Latral Sclrosis inducd astrocytosis and motonuron dath Lazio Michtti Fabrizio Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 245 di 356

246 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Combind targting of cancr clls and tumor supporting micronvironmnt by Natural Killr T lymphocyts nginrd with tumor spcific TCRs SAN RAFFAELE MILANO Dllabona Paolo Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Th possibl influnc of fat solubl vitamins on cognition and brain structural intgrity in patints with Scondary Progrssiv Multipl Sclrosis: a longitudinal study. SANTA LUCIA Nocntini Ugo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A RANDOMIZED OPEN LABEL STUDY COMPARING EVEROLIMUS AT DIFFERENT DOSES WITH STANDARD THERAPY IN THE ABILITY TO DELAY THE PROGRESSION OF DIABETIC NEPHROPATHY Puglia DI PAOLO SALVATORE Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Impact of dit and physical activity on quality of lif and outcom of patints opratd for lung cancr I.E.O. Gnagnarlla Patrizia Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC CirculAting VEsicls: Th hiddn sits of nurodgnration (CAVE) FATEBENEFRATELLI Ghidoni Robrta Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rsidual volution of HIV nv V3 squnc in virologically supprssd patints undrgoing Maravirocincluding antirtroviral thrapy. March Bagnarlli Patrizia Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Nw insights in th diagnosis and managmnt of patints with mitochondrial disordrs in th viw a nw thraputic ra: natural history, biomarkrs, outcom masurs and quality of lif Sicilia Musumci Olimpia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Improving aphasia rhabilitation: Nw tools for administring and dircting thrapy SANTA LUCIA Guariglia Ccilia Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 246 di 356

247 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Analysis of th intrplay btwn oxidativ strss and familiarity for atrial fibrillation Lazio violi francsco Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF IMPROVING QUALITY AND CARE OPTIONS FOR THE END OF LIFE IN ADVANCED HEART FAILURE. Toscana EMDIN MICHELE Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Antibodis long trm prsistnc and mmory clls rol aftr diffrnt pnumococcal vaccin stratgis in HIV adults Toscana Montagnani Francsca Clinicoassistnzial Immunology Immunity and Host Dfns IHD Transmmbran Rcptors/Trasforming Growth Factor Bta Rcptors Biasd Crosstalk: A Novl Concpt for Nanothrapy of Cardiac Fibrosis in Hart Failur Campania Esposito Giovanni Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Natural y drops from allognic umbilical cord blood plasma Istituto Suprior di Sanita' Grazzini Giuliano Biomdica Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Antidprssant activity of fingolimod in xprimntal animal modls and patints with multipl sclrosis NEUROMED Bruno Valria Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Embryonal tumors of th brain: analysis of pigntic ntworks NEUROMED Gulino Albrto Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Activ survillanc or radical tratmnt in patints with nwly diagnosd low risk prostat cancr: a populationbasd comparativ ffctivnss study in th Oncological Ntwork of Pidmont and Vall d'aosta Pimont Ciccon Giovannino Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Undrstanding Human Papillomavirus (HPV) Natural Infction in Had and Nck Cancr to Dvlop Nw Prvntiv, Diagnostic, and Tratmnt Stratgis Pimont SUCCO GIOVANNI Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 247 di 356

248 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv EFFECTIVENESS OF 3D ULTRASOUND GUIDED SURGERY IN IMPROVING PATIENTS CLINICAL OUTCOME AND SURVIVAL IN BRAIN TUMOURS SAN RAFFAELE MILANO Mortini Pitro Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Physically drivn nanocarrirs for th controlld dlivry of apomorphin and lvodopa in Parkinson's disas AUXOLOGICO PRIANO LORENZO Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD NOVEL STRATEGIES FOR MOLECULAR DIAGNOSIS AND RISK STRATIFICATION OF PATIENTS WITH CHRONIC HEART FAILURE. Campania Piscion Fdrico Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Counslling and Srvic Dlivry program to incras th adhrnc to Mditrranan Dit and to rduc th risk of cardiovascular disas Emilia Romagna STORCHI MARCO Clinicoassistnzial Risk, Prvntion and Halth Bhavior Psychosocial Risk and Disas Prvntion PRDP Studis on th rol of th nuron astrocyt microglia triad in th pathognsis of crbral ischmia Toscana Pllgrini Domnico Biomdica Brain Disordrs and Giampitro Edoardo Nuroscinc Brain Injury and Nurovascular Pathologis BINP Assssing th Risk of Falls in th Eldrly of Long trm car institutions through Instrumntal Sit to stand tst (ARFELIS) DON GNOCCHI Castiglioni Paolo Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Th gntics of suddn cardiac dath in athlts and implication for risk prvntion Vnto THIENE GAETANO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Dvlopmnt of nw biomarkrs to stratify th PML risk in multipl sclrosis patints during Natalizumab thrapy: study of th potntial corrlation btwn prsnc of human Polyomavirus JC DNA in blood/urin sampls and cytokin chmokin profiling in p Lazio Pitropaolo Valria Antonitta Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 248 di 356

249 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Immun rspons to human cytomgalovirus in th immunocomptnt and th immunocompromisd host: nw approachs and thir clinical impact SAN MATTEO spinillo arsnio Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Influnc of microbioma on biological activity of CXCR4, CCR5 and CCR6 during a mucosal chronic inflammation. SAN RAFFAELE MILANO Pastori Claudia Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun EZH2 pigntic rgulation of th HIPK2/p53/Pin1 circuitry in chmorsistant mlanoma: idntification of molcular switchs as nw thraputic targts ISTITUTO DERMOPATICO DELL'IMMACOLATA ciarapica robrta Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP LEFT VENTRICULAR HYPERTROPHY IN AORTIC VALVE DISEASE AND HYPERTROPHIC CARDIOMYOPATHY: GENETIC BASIS, BIOPHYSICAL CORRELATES AND VIRAL THERAPY MODELS Toscana Olivotto Iacopo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF EXOME SEQUENCING IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) PATIENTS Emilia Romagna VAGLIO AUGUSTO Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Immigrants and sanitation: an accurat diagnosis to assss th sprad of parasitic infctions and th associatd immun modulation Campania Galdiro Massimiliano Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Idntification and validation of gns that control cllular plasticity, as novl cancr thraputic targts. I.E.O. Moroni Mariacristina Biomdica Oncology 1 Basic Molcular Oncognsis MONC ROLE OF TUMOR MICROENVIRONMENT IN IMMUNE MODULATION Toscana Amdi Amdo Biomdica Oncology 1 Basic Tumor Micronvironmnt TME rlvanc of constitutional non truncating mutations in APC gn: an intgratd analysis to dfin th association btwn variants of uncrtain significanc and gntic risk of colo rctal polyposis and cancr C.R.O. AVIANO Vil Alssandra Biomdica Oncology 1 Basic Cancr Gntics CG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 249 di 356

250 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Inhibition of Glycolysis by 2 Doxy D Glucos as a Thraputic Stratgy for Polycystic Kidny Disas SAN RAFFAELE MILANO magistroni riccardo Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Mutatd calrticulin as a novl diagnostic markr and thraputic targt in chronic myloprolifrativ noplasms Toscana Vannucchi Alssandro Biomdica Oncology 2 Maria Cancr Immunopathology and Immunothrapy CII Intrplay btwn autophagy and S nitrosylation: implications in th gnsis, prolifration and rsistanc of glioblastoma stm clls SANTA LUCIA Ccconi Francsco Biomdica Oncology 1 Basic Tumor Cll Biology TCB Improving standards of car in Young Womn with Brast Cancr: a translational approach C.R.O. AVIANO Massarut Samul Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Assssmnt of gastrointstinal comorbiditis in Autism Spctrum Disordrs (ASD) Campania bravaccio carmla Biomdica Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Analysis of th rol of oxystrols/lxrs in tumorignsis SAN RAFFAELE MILANO Russo Vincnzo Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Crbrospinal fluid microparticls as biomarkrs of Primary Progrssiv Multipl Sclrosis: a cas control study Sicilia Salmi Giuspp Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT In vitro and in vivo studis of homocystin inducd nurodgnration and potntial protctiv/rparativ ffcts of nutracutical compounds Sicilia CACCAMO DANIELA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Rol of ApoL1 in th Pathognsis of HIV Associatd Nphropathy HUMANITAS Mikulak Joanna Biomdica AIDS and Rlatd Rsarch NuroAIDS and othr End organ Disass NAED Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 250 di 356

251 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of ovarian cancr micronvironmnt and rlatd inflammatory and mtabolic changs in th pathognsis of patint's symptoms. rsarch for th implmntation of a mchanism basd tratmnt approach. Sardgna Macciò Antonio Biomdica Oncology 2 Oncology CONC Idntification of human gns involvd in th pathognsis of kratoconus Vnto Ponzin Digo Biomdica Brain Disordrs and Nuroscinc Antrior Ey Disas AED Th impact of a modrat CAlori and protin REstriction PROgram (CARE PRO) as an fficint and affordabl thrapy in patints with Barrtt's Esophagus. I. O. V. Raldon Stfano Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM ICAROS Indagin sui Clustr di Aumnto dl Rischio Oncologico in Salnto Puglia PISCITELLI PRISCO Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Validation of th prdictiv rol of LH Rcptor xprssion for ndomtrial cancr patints stratification. Toscana NOCI IVO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Prokinticin 2 in autoimmun dmylinating disas of th cntral nrvous systm: a possibl novl targt for immun intrvntion CARLO BESTA Pdotti Rostta Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Macrophags and th dvlopmnt of fibrosis during nonalcoholic fatty livr disas: rol of intraction btwn iron mtabolism and hypoxia inducibl factor 2alpha Toscana Marra Fabio Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Nw halth car modl for intgratd multidisciplinary managmnt and surgical tratmnt of complx plvic floor dysfunctions: conomic valuation, carflow managmnt and applicability to othr clinical srvics Emilia Romagna Ascanlli Simona Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 251 di 356

252 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Implmntation of adhrnc work up by thraputic drug monitoring (TDM) and intgratd hmodynamic status assssmnt, for th managmnt of rsistant hyprtnsion (RH) Pimont VEGLIO FRANCO Clinicoassistnzial Vascular and Hmatology Hyprtnsion and Microcirculation HM Nw diagnostic and thraputic approachs in oncology basd on th UN1/CD43 tumor antign. Calabria Palmiri Camillo Biomdica Oncology 2 Cancr Biomarkrs Hrditary Spastic Paraplgia: sarch for disas gns by a ntwork basd approach SANTA LUCIA ORLACCHIO ANTONIO Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration IDENTIFICATION OF VASOACTIVE MEDIATORS CORRELATING WITH HEMODYNAMIC ALTERATIONS IN NEUROLOGICAL DISEASES: COMPARISON BETWEEN MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASES Toscana Monti Lucia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nuclotid Excision Rpair and Acclratd Vascular Aging ISTITUTO DERMOPATICO DELL'IMMACOLATA Dllambra Elna Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Analysis of dfcts in th dvlopmnt of intrnurons causd by dysrgulation of Rac signaling rlvant to nuropsychiatric disordrs. SAN RAFFAELE MILANO d Curtis Ivanmatto Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurodiffrntiation, Plasticity, and Rgnration NDPR Prinatal Asphyxia, Nuroprotctiv Stratgis and Brain Biomarkrs Pimont Gazzolo Digo Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Rol of th p21 mdiatd DNA Damag Rspons in th immun survillanc of lukmia stm clls I.E.O. PELICCI PIER GIUSEPPE Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Zoonotic potntial and pathognic rol of th intstinal parasit Dintamoba fragilis in pigs IZSUM Manuali Elisabtta Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 252 di 356

253 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Kynurnin Pathway Mtabolits and Suicid risk; a potntial biomarkr for suicid prvntion Lazio Pompili Maurizio Clinicoassistnzial Risk, Prvntion and Halth Bhavior Psychosocial Dvlopmnt, Risk, and Prvntion PDRP Blood brain barrir prmability in ALS from in vitro to in vivo AUXOLOGICO Bossolasco Patrizia Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Th functional rol of Eukaryotic translation initiation factor 4h in Williams Burn Syndrom: sarching its dirct downstram targts. SAN RAFFAELE MILANO Panns Maria Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Rol of non coding RNAs in ostosarcoma stmnss Toscana Brandi Maria Luisa Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Host rspons to hrps simplx virus 1 (HSV1) rcurrnt infctions and Alzhimr's disas: looking for pathogntic corrlations and thraputic vaccins. SAN RAFFAELE PISANA PALAMARA ANNA TERESA Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB Gnomic and post gnomic analysis of patints with rhumatoid arthritis tratd with biological agnts complicatd by srious infctions Lombardia Riva Agostino Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Analysis of th impact of systmic autoimmun disass on frtility, family planning, and on th family structur of patints. Toscana Mosca Marta Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Immunologic and complmnt activation mchanisms for antibody mdiatd rjction and mixd rjction in hart and kidny transplantation: th rol of molcular biomarkrs for diagnostic, prognostic and thraputic stratgis. Vnto Anglini Annalisa Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS BRAIN NETWORK DEGENERATION ASSESSED USING MULTIMODAL MRI TO EXPLAIN CLINICAL VARIABILITY IN ALZHEIMER'S DISEASE SAN RAFFAELE MILANO Magnani Giuspp Clinicoassistnzial Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 253 di 356

254 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Epidmiology of strok in th L'Aquila district Abruzzo Sacco Simona Clinicoassistnzial Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME Targting attntion biass in dprssion: A longitudinal fmri study SANTA LUCIA Fagioli Sabrina Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Flow dynamic valuation of ndovascular aortic arch rconstruction by cardiovascular MRI with 4D tchnology and computational analysis Vnto Antonllo Michl Clinicoassistnzial Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Advancd in vitro fficacy prdictivo tools for prsonalizd dsign of immun chckpoint blockad immunothrapy Lazio Santini Danil Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Atrial Tissu Charactristics and Mtabolic Dysrgulation in Post Oprativ Atrial Fibrillation. A Substudy of th OPERA Intrnational Trial Emilia Romagna Corradi Domnico Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Fosl2 as a p53 antagonist in cancr dvlopmnt and progrssion C.R.O. AVIANO Piccinin Sara Biomdica Oncology 1 Basic Molcular Oncognsis MONC Disscting host pathogn intrplay: a systms biology approach to discovr Plasmodium falciparum and Anophls gambia intractors Istituto Suprior di Sanita' Pizzi Elisabtta Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Idntification and targting of high risk subgroups in pdiatric acut lymphoblastic lukmia: Ph lik and Down Syndrom ALL Lombardia Biondi Andra Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 254 di 356

255 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Atypical Hmolytic Urmic Syndrom (ahus): Exprimntal protocol of patint monitoring by combind analysis of Eculizumab lvls and its inhibitory ffct and corrlation with clinical paramtrs and C5b 9 dposits on ndothlial clls MARIO NEGRI Brsin Elna Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun From micro GIST to ovrt GIST: dissction of th molcular altrations involvd in GISTmalignant volution C.R.O. AVIANO Gasparotto Danila Biomdica Oncology 2 Cancr Biomarkrs Targting th Calcinurin GSK3 axis in T cll acut lymphoblastic lukmia I. O. V. Piovan Erich Biomdica Oncology 2 Cancr Biomarkrs RANDOMIZED PLACEBO CONTROLLED STUDY OF LOW MOLECULAR WEIGHT HEPARIN (LMWH) FOR THE PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN NEWLY DIAGNOSED NON HODGKIN LYMPHOMA PATIENTS (NHL) Pimont Santi Robrto Mario Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT MOLECULAR DISSECTION OF THE PI3K/AKT PATHWAY IN GLIOBLASTOMA: IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL TARGET THERAPIES BASED ON SMALL MOLECULES. CASA SOLLIEVO SOFFERENZA Parrlla Paola Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Exosoms omics: a vhicl for tumor stroma communication and clinical translation in pancratic cancr Vnto Basso Danila Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Enginrd UC MSCs in multipl myloma tratmnt: a prclinical cytothrapy modl for both killing of tumor clls and haling ostolytic bon lsions. Puglia SILVESTRIS FRANCESCO Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Epigntics in nurodgnrativ dmntias: circulating clls and drivd pluripotnt stm clls (ipscs) from patints to idntify pathognic mchanisms and potntial biomarkrs SANTA LUCIA Fuso Andra Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 255 di 356

256 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of vitamin D and B status on cllular aging and ag rlatd disass Provincia autonoma Bolzano Hrrmann Markus Clinicoassistnzial Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD Nw Biomolcular tools for Murin Typhus Diagnosis Calabria LUCIANI FILIPPO Biomdica Infctious Disass and Microbiology Disscting WT1 mutations in lukmia I. O. V. Tosllo Valria Biomdica Oncology 1 Basic Rsarch and Fild Studis of Infctious Disass CRFS Tumor Cll Biology TCB REWIND Rcovry of Equilibrium during Walking IN patints with strok rlatd Disass SANTA LUCIA Paolucci Stfano Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Calcinurin inhibitors (CNIs) monitoring in priphral blood mononuclar clls (PBMCs) in th clinical car of d novo hart transplantd patints Pimont Rinaldi Mauro Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training Fllowship: Chmical and Bioanalytical Th Impact of Hypoxia and MicroRNA Control on Dystrophin associatd Protin Complx (DPC )protins during Nuronal Diffrntiation: Implications for Cognitiv Dficits in Duchnn Muscular Dystrophy Istituto Suprior di Sanita' Macioc Pompo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurognsis and Cll Fat NCF Rol of migrants in tubrculosis, vctors and vctorborn disas sprad IZSSI Caracappa Santo Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Acquisition, analysis and managmnt of clinical, social and go mdical data aiming at studying and dvloping pidmiological modls of disass with high social and conomic impact in Calabria rgion Calabria Cuda Giovanni Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 256 di 356

257 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of causativ gn(s) for rar ntric nuropathis by nxt gnration squncing and functional studis in zbrafish GASLINI Matra Ivana Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Inactivation of th tumor supprssor IRF 1 by th IkappaB kinas (IKK) psilon in brast cancr: idntification of druggabl targts through protomic analysis Istituto Suprior di Sanita' MARSILI GIULIA Biomdica Oncology 1 Basic Molcular Oncognsis MONC Cardiac and Vascular strss cho during normobaric hypoxia in coronary hart disas patints and halthy subjcts: A nw non invasiv, low cost tst to improv safty of rcrational mountain climbrs and workrs at high altitud. Vall d'aosta GIARDINI GUIDO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS LIVER REGENERATION ENHANCEMENT: PRE CLINICAL AND FIRST IN MAN CLINICAL STUDY TO ASSESS THE SAFETY AND EFFICACY OF HUMAN ADIPOSE DERIVED MESENCHYMAL STEM CELLS. Sicilia Spada Marco Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Nw prspctivs in th prvntion of Diabts dpndnt cognitiv dclin Calabria Arturi Franco Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Diabts, Mtabolism, Nutrition and Obsity Small Businss SEP (EMNR E10 B) Effct of CHRNA7 gnotyps on th cognitiv rspons to actylcholinstras inhibitor (AChEI) tratmnt (Donpzil) at Diffrnt Stags of Alzhimr's Disas SAN RAFFAELE PISANA RUSSO PATRIZIA Clinicoassistnzial Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Epithlial ovarian cancr: affcting tumor growth by targting abrrant mtabolism ISTITUTO TUMORI MILANO Bagnoli Marina Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Th Pharmacomtrics for NuroBlastoma (P4NB) Projct: Intgratd Systms Biology and Quantitativ Analyss to Guid Prsonalizd Tratmnt and Orphan Drug Dvlopmnt in High Risk NB GASLINI garavnta albrto Biomdica Oncology 2 Dvlopmntal Thraputics DT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 257 di 356

258 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Effcts of a wb controlld hom basd xrcis intrvntion in modulating ndothlial dysfunction and rlatd humoral markrs in coronary patints across th spctrum of abnormal glucos mtabolism. DON GNOCCHI Frratini Maurizio Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Th first Moyamoya disas Italian Ntwork: th intgration of clinics with gntic and cllular approachs for undrstanding th pathophysiology of this rar and complx disas CARLO BESTA Brsano Anna Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Effctivnss of a cognitiv bhavioral and lifstyl intrvntion in rducing cardiovascular risk factors and cardiovascular morbidity among patints with svr mntal illnss tratd with antipsychotics Lombardia crvri giancarlo Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Dvlopmnt and charactrization of non invasiv and clinically rlvant mous modls of drug rsistant lukmia: cllular, molcular, and functional studis dirctd to th idntification of thraputic targts for chmothrapy rsistant human lukmia c IZSLER LOMBARDI GUERINO Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Abrrant gns on chromosom 10 opn nw prspctivs into th molcular pathognsis of Cutanous T cll Lymphoma ISTITUTO DERMOPATICO DELL'IMMACOLATA Russo Giandomnico Biomdica Oncology 1 Basic Cancr Gntics CG MOLECULAR ANALYSIS AND HISTOLOGICAL CHARACTERIZATION OF MELANOCYTIC METASTATIC PHENOTYPE ACCORDING TO THE EXPRESSION OF MCAM/MUC18 CELLULAR ADHESION MOLECULE, METALLOPROTEINASES AND ANGIOGENIC FACTORS Lazio Bianchi Luca Clinicoassistnzial Oncology 2 Cancr Biomarkrs Bta actin oxidation: a nw prdictiv biophysicalbiochmical markr for autism Toscana Hayk Joussf Biomdica Biological Chmistry and Macromolcular Biophysics Biochmistry and Biophysics of Mmbrans BBM Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 258 di 356

259 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Strngthning th italian participation to indpndnt, nonprofit randomizd clinical trials in Europ by supporting and implmnting ItaCRIN, th italian hub of ECRIN consortium. Istituto Suprior di Sanita' Palmisano Lucia Clinicoassistnzial Halthcar Dlivry and Mthodologis Biostatistical Mthods and Rsarch Dsign BMRD Familial brast and mlanoma disass: common and diffrnt gntic and pigntic faturs ONCOLOGICO DI BARI Tommasi Stfania Biomdica Oncology 2 Cancr Biomarkrs Dsign, Synthsis and Prclinical valuation of novl pptidomimtic activ against ESKAPE pathogns and agnt of zoonosis Emilia Romagna BARONI MARIA Biomdica Infctious Disass and CRISTINA Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Enabling BCI assistd bdsid dtction of intntion to communicat and communication in functional Lockdin syndroms aftr acquird brain injury SANTA LUCIA Formisano Rita Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Nw tchnolgis in th diagnosis and survillanc of invasiv bactrial infctions in Italy:an ssntial tool in th planning and monitoring of prvntion stratgis Toscana Rsti Massimo Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS IMMUNOLOGICAL MECHANISMS IMPLICATED IN THE DEVELOPMENT OF HYPERTENSION AND MORPHOFUNCTIONAL MICROVASCULAR ALTERATIONS. Lombardia Rizzoni Damiano Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Tailord communication stratgis to improv lifstyl habits in womn at intrmdiat/high risk of dvloping brast cancr: a Randomisd Control Trial in a scrning stting. Pimont Giordano Livia Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Unicllular ukaryots as biomarkrs of intstinal dysbiosis in patints with Irritabl Bowl Syndrom (Diarrhoa prvalnt, IBS D) and Functional Diarrhoa Istituto Suprior di Sanita' Simon Mario Caccio Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F13 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 259 di 356

260 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Targting hmatological malignancis by TCR gn ditd mmory stm T clls SAN RAFFAELE MILANO Bonini Chiara Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII utility of a nxt gnration squncing basd "oncochip" for thraputic dcision in mtastatic brast cancr I.E.O. CURIGLIANO GIUSEPPE Clinicoassistnzial Oncology 2 Oncology CONC Inflammasom and bladdr cancr: impacts on diagnosis and post surgical managmnt Umbria Marini Ettor Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII "Primary car managmnt" to addrss patints with complx halth car nds in an ara basd halth car systm Vnto Toffanin Robrto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Prognostic vidnc in Halth Tchnology Assssmnt Agnzia pr i Srvizi Sanitari Rgionali Jffrson Tom Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Idntification of nw thraputical targts of cancr stm clls: study of th mchanistics of mitotic spindl alignmnt to cortical polarity in mammary stm cll asymmtric divisions I.E.O. MAPELLI MARINA Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function C MSFC A comprhnsiv NGS basd approach for th dfinition of th molcular bass of th hrditary dysmylinating disordrs of th cntral nrvous systm CARLO BESTA Di Blla Danila Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD E cadhrin and signalling pathway componnts for using in clinic as diagnostic and prognosticvalu in gastric carcinoma C.R.O. AVIANO D R Valli Biomdica Oncology 2 Cancr Biomarkrs On Halth approch to valuat Hpatitis E virus infction burdn in humans and swin in March and Lazio rgions, risk factors and pathognic potntial of diffrnt virus strain IZSUM Duranti Anna Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 260 di 356

261 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Unravlling th impact of diffrnt tratmnt stratgis on intra clonal htrognity in Multipl Myloma Emilia Romagna Cavo Michl Biomdica Gns, Gnoms and Gntics Gntic Variation and Evolution GVE PROSTATE CANCER: A STUDY ON THE MOLECULAR MECHANISMS UNDERLYING THE DEVELOPMENT OF CASTRATION RESISTANT PHENOTYPE IRCCS AOU San Martino IST (Gnova) Balbi Ccilia Srnlla Biomdica Oncology 1 Basic Tumor Cll Biology TCB A promising tratmnt option for Bisphosphonat Rlatd Ostoncrosis of th Jaw (BRONJ) basd on ostoblasts/ostoclasts co culturing on multifunctional scaffolds. Abruzzo Adriano Piattlli Biomdica Musculoskltal, Oral and Skin Scincs Oral, Dntal and Craniofacial Scincs ODCS Cllular snscnc biomarkrs in priphral blood mononuclar clls (PBMC) of Alzhimr Disas I.N.R.C.A. Costarlli Laura Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Innovativ anti angiogntic compounds for human disass MULTIMEDICA Noonan Douglas M Biomdica Vascular and Hmatology Vascular Biology Spcial Emphasis Panl SEVB Th Italian National Quitlin and thr Rgional Tlphon Srvics to follow smokrs in thir quit attmpts through tlphon counslling and facilitating contacts with local Tobacco Cssation Srvics Toscana GORINI GIUSEPPE Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA High risk pigntic biomarkrs in th onst of malignant plural msothlioma in asbstos xposd subjcts ONCOLOGICO DI BARI Galtta Domnico Biomdica Oncology 2 Cancr Biomarkrs Comparing ffctivnss and cost ffctivnss of socialcar halth car trajctoris xprincd by frail oldr popl in ral lif Lombardia Annoni Giorgio Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Potntial us of Circulating Mlanoma Clls (CMCs) in dog: a spontanous cancr modl for studying mtastasis IZSVE VASCELLARI MARTA Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 261 di 356

262 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Impact of an Enhancd Rcovry Aftr Surgry (ERAS) program on physical prformanc and muscl strngth in ldrly patints undrgoing lctiv colorctal rsction for cancr Emilia Romagna VOLPATO STEFANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Exprssion and function of P2 rcptors in human psoriatic kratinocyts. Study of thir rol in psoriasis pathognsis and rsarch of nw potntial thraputic targts ISTITUTO DERMOPATICO DELL'IMMACOLATA Albansi Cristina Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Dvlopmnt of aptamrs as novl diagnostic and thraputic tools for Diabts Mllitus HUMANITAS Malosio Maria Luisa Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Molcular Imaging and Prob Dvlopmnt CMIP Effct of strss ( and psychological factors) on immun and ndocrin systms in patints affctd by brast carcinoma and hormon corrlatd tumours. I.N.R.C.A. Vspa Anna Clinicoassistnzial Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Idntification of nw molcular thraputic targts in Mdullary thyroid cancr using nxt gnration squncing basd approachs CASA SOLLIEVO SOFFERENZA Torlontano Massimo Biomdica Oncology 2 Cancr Biomarkrs Pharmacogntic modulation of Ras ERK signalling in mous modls of striatal nurodgnration and cognitiv dclin SAN RAFFAELE MILANO Brambilla Riccardo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND BRIDGING THE TUMOR MACRO AND MICRO ENVIRONMENT: THE ROLE OF METABOLIC AND NEUROENDOCRINE FACTORS IN BREAST CANCER PROGRESSION Istituto Suprior di Sanita' Cirulli Francsca Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH PYB Protct Your Back (Effctivnss of Back Protctor in prvnting spinal cord injuris) Istituto Suprior di Sanita' Giustini Marco Biomdica Risk, Prvntion and Halth Bhavior Psychosocial Dvlopmnt, Risk, and Prvntion PDRP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 262 di 356

263 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Virological and molcular charactristics of Human Papillomavirus (HPV) : a study on prvalnc and prsistnc in oral cavity and ano gnital sits in HIVpositiv patints SPALLANZANI Garbuglia Anna Rosa Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB DEVELOPMENT AND VALIDATION OF A NOVEL LABORATORY IN VITRO ASSAY AIMED AT PREDICTING ALLERGIC OR TOLERANT RESPONSES TO CONTACT ALLERGENS SAN GALLICANO Bordignon Valntina Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun A novl playr in ovarian cancr vasculatur: biological rol and thraputic implications I.E.O. Cavallaro Ugo Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Srum tryptas and chymas: nw biomarkrs in patints with acut coronary syndrom. Lombardia Losappio Laura Michlina Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM CARDIOVASCULAR SCREENING OF LONG TERM CANCER SURVIVORS AFTER CHEST RADIATION THERAPY. C.R.O. AVIANO Lstuzzi Chiara Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Gut Bactria (microbiota) in HpAtic EncphaLopathy and Possibl Utility of its Modulation (th GOAL study) DE BELLIS Landro Gioacchino Clinicoassistnzial Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Srum sialic acid binding immunoglobulin lik lctin 7 (Siglc 7) as a biomarkr of livr inflammation and fibrosis in hpatitis C and othr chronic viral infctions SAN MATTEO MONDELLI MARIO Biomdica Infctious Disass and UMBERTO Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Disscting Kabuki syndrom by cllular modlling and gnom wid analysis CASA SOLLIEVO SOFFERENZA Mrla Giuspp Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 263 di 356

264 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F FDG PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT Sicilia scollo paolo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Application of a standardizd ERAS (Enhancd Rcovry Aftr Surgry) prioprativ pathway in rsctiv sophagal surgry: ffcts on morbility, mortality, lnght of hospital stay, costs, and quality of lif SAN RAFFAELE MILANO Rosati Riccardo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Rol of srotonin in modulating L DOPA inducd dyskinsia SANTA LUCIA Picconi Barbara Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Dvlopmnt of human Msnchymal Stm Cll drivn bon marrow micronvironmnts/nichs supporting hmopoisis and controlling hmatopoitic and nonhmatopoitic tumor growth in vivo IRCCS AOU San Martino IST (Gnova) Cancdda Raniri Biomdica Cll Biology Intrcllular Intractions ICI Th PRECISE (PRocdural failure aftr CardIovascular Surgry in th Eldrly) projct SAN DONATO Ranucci Marco Maria Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Th alpha Mlanocyt Stimulating Hormon/ Proxisom Prolifrator Activatd Rcptor gamma connction: nw insights on mlanoma risk assssmnt SAN GALLICANO Marsca Vittoria Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS A multidisciplinary invstigation for th improvmnt of aortic ndografting: from biomdical nginring concpts to clinical implmntation SAN DONATO Trimarchi Santi Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 264 di 356

265 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Emrging halth&food safty/scurity risks from combind organic chmical, pharmacutical, and microbial hazards from civil wastwatr tratmnt plants sludgs rcycld as top soil improvrs in agricultur: "SAFE SOIL". Istituto Suprior di Sanita' Brambilla Gianfranco Biomdica Vtrinary Food Safty FOSA Rol of gn mthylation in th risk of ischmic strok NEUROMED Iacovillo Licia Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Microglia/macrophags as cllular targt of novl CXCR4 antagonist and radiothrapy combind tratmnt in glioma modls Istituto Suprior di Sanita' Ajmon Cat Maria Biomdica Brain Disordrs and Antonitta Nuroscinc Nuroimmunology and Brain Tumors CNBT Vascular complications in patints with chronic myloid lukmia: valuation of possibl advrs ffcts of nilotinib on ndothlial function. IRCCS AOU San Martino IST (Gnova) Palombo Domnico Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT T10 cllular immunothrapy in kidny transplantation to induc donor spcific tolranc SAN RAFFAELE MILANO Caldara Rossana Clinicoassistnzial Immunology Transplantation, Tolranc and Tumor Immunology TTT Advancd MRS, ASL prfusion and structural MRI in pdiatric migrain: a longitudinal study and corrlations with clinical and nurophysiological findings. OSPEDALE BAMBINO GESU' Valriani Massimiliano Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Targtd xom squncing to idntify novl putativ gntic variants associatd with Gstational Diabts Mllitus Calabria Androzzi Francsco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO From lifstyl to mitochondrial bnfits: study on a combind thraputic approach tohuntington's disas Istituto Suprior di Sanita' Visntin Srgio Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Diffrntial Rols of Lft & Right Antrior/Polar Prfrontal Cortx (BA 10/11) in Ral World Problm Solving S.CAMILLO Gol Vinod Biomdica Biobhavioral and Bhavioral Procsss Cognition and Prcption CP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 265 di 356

266 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Optimizing managmnt of svr infctions du to drug rsistant gram ngativ bactria in hospitalisd patints Campania Durant Mangoni Emanul Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Extnsiv gntics and functional nuroimaging in ALS: rvaling mchanisms of disas progrssion (GNuPro ALS). IRCCS AOU San Martino IST (Gnova) Mandich Paola Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD A randomizd controlld clinical trial to assss th rol of msalazin as a modulator of gut microbial translocation and systmic immun activation in chronically infctd, ART tratd HIV subjcts Istituto Suprior di Sanita' Baronclli Silvia Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Prognostic valu of lung ultrasound in patints admittd for congstiv hart failur: a prospctiv obsrvational study Lombardia Montano Nicola Biomdica Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS Dvlopmnt and production of a novl dcllularizd drmal matrix for rconstructiv surgry procdurs. Pimont Castagnoli Carlotta Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI A bnch to bdsid approach to th rational us of targtd thrapis in ultra rar ntitis: th cas of xtraskltal myxoid chondrosarcoma and antiangiognics ISTITUTO TUMORI MILANO Stacchiotti Silvia Clinicoassistnzial Oncology 2 Oncology CONC An intgratd ntwork of cntrs of xcllnc to prform a sris of clinical studis to assss fficacy, fficincy, safty, and appropriat clinical indications of xtracorporal mmbran oxygnation (ECMO) in patints with svr pulmonary failur Pimont Fanlli Vito Clinicoassistnzial Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Improving thraputic appropriatnss of Multipl Sclrosis tratmnts using biological approachs to prsonaliz thrapy and sav pharmacutical spnding Pimont Brtolotto Antonio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 266 di 356

267 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of a biological ntwork as potntial usful tool for monitoring, prvnting and dvloping prsonalisd tratmnts for sporadic thoracic aortic anurysm Sicilia Ruvolo Giovanni Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Autologous Adipos Tissu Drivd Msnchymal Stm Clls Enrichmnt and Isolation for th Tratmnt of Patints with Dgnrativ Hip Ostoarthritis Pimont Frracini Riccardo Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Skltal Biology Structur and Rgnration SBSR Unravling th molcular mchanisms that undrli brain mtastasis formation from brast cancr. I.E.O. PELICCI GIULIANA Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Novl thraputic stratgis for Frontotmporal Lobar Dgnration by targting progranulin rlatd inflammatory pathways MARIO NEGRI ALBANI DIEGO Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Fasibility of LINAC basd StroBody Radiothrapy (SBRT) in 3 fractions for low to intrmdiat/low risk prostat cancr REGINA ELENA Sanguinti Giuspp Clinicoassistnzial Oncology 2 Oncology CONC Italian study on gn nvironmnt intractions in lymphoma atiology: translational aspcts Toscana Miligi Lucia Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC Dysrgulatd JAK function in acut lymphoblastic lukmia Istituto Suprior di Sanita' Flx Elisabtta Biomdica Oncology 1 Basic Molcular Oncognsis MONC Nar road xposur and halth ffcts of Ultrafin Particls INAIL gariazzo claudio Biomdica Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Ontology and radmission: rol of halth communications tchnologis in frail patints dischargd from intrnal mdicin dpartmnt Emilia Romagna FABBIAN FABIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Community Lvl Halth Promotion CLHP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 267 di 356

268 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Occurrnc of Ostropsis gnus blooms in Tyrrhnian sa: tools to prvnt human intoxication du to palytoxins contaminatd safood. Immuno modulatory mchanisms may b rlvant in shaping th bon marrow micronvironmnt in patints with primary mylofibrosis: valuation of th possibl rol of msnchymal stromal clls. Istituto Suprior di Sanita' Cozzi Lordana Biomdica Vtrinary Food Safty FOSA SAN MATTEO Massa Marghrita Biomdica Immunology Cllular and Molcular Immunology B CMIB Ultra high fild (UHF) sodium (23Na) MRI imaging as noninvasiv biomarkr for masuring structural changs and assssing prognosis of pathology in pdiatric brain tumors STELLA MARIS Tostti Michla Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI UNDERSTANDING SPACE AND ACTION PERCEPTION IN SPINAL CORD INJURED PEOPLE: NEUROSCIENTIFIC AND TRANSLATIONAL IMPLICATIONS Vnto moro valntina Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG MUTATIONAL ANALYSIS, NEOANGIOGENESIS, AND CELL LINEAGE TRACING AS NEW COMPLEMENTARY APPROACHES TO DISCRIMINATE THE RISK OF MALIGNANT TRANSFORMATION IN ADENOMATOUS LIVER LESIONS. Emilia Romagna D'rrico Antonitta Clinicoassistnzial Oncology 2 Cancr Biomarkrs Priphral blood total nuclatd clls for th tratmnt of critical limb ischmia ISTITUTO DERMOPATICO DELL'IMMACOLATA Grmani Antonia Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Burdn of Cancr in thr Italian population basd cancr rgistris and attributabl fraction to main risk factors Istituto Scintifico Romagnolo falcini fabio Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Computrizd Intrconnctd Infusion Safty Systms (CIISSs) for prvnting administration rrors Istituto Scintifico Romagnolo Znli Anita Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 268 di 356

269 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Toll Lik rcptors (TLRs) a nw biomarkr for undrstanding oral and oro pharyngal carcinognsis and tumor progrssion rlatd to Human Papillomavirus (HPV) infction?a multicntr study on low/high grad pithlial dysplasia and cancr HPV+v vrsu Sicilia campisi giusppina Biomdica Oncology 2 Cancr Biomarkrs Ditary advancd glycation nd products and cardiovascular risk: animal and human studis Istituto Suprior di Sanita' Riganò Rachl Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Undrstanding th molcular bass of intllctual disability and autism spctrum disordrs associatd with macrocrania/macrosomia (IAMM). Istituto Suprior di Sanita' cordddu viviana Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Rol of xtracllular vsicls in bon tumour pathognsis: implications for thrapy OSPEDALE BAMBINO GESU' Muraca Maurizio Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Dvlopmnt and Disas SBDD "Charactrization of mylopoisis disordrs: unrvaling th rol of GATA2 and rlatd factors in prdicting patints' clinical outcom and stablishing a timly tratmnt" Toscana Gambinri Elonora Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Novl thraputic approachs to slow muscular dystrophy progrssion: idntification ofpotntial targts through molcular dissction of th altrations in mitochondrial biognsisand in its pigntic control Lombardia Clmnti Emilio Biomdica Musculoskltal, Oral and Giuspp Skin Scincs Ignazio Skltal Muscl Biology and Exrcis Physiology SMEP Impact and ffctivnss of clinical pharmacyst's intrvntions in th multidisciplinary car of HIV infctd patints with comorbiditis including cancr, tratd with polypharmacy. A randomizd controlld clinical trial to assss halth outcoms by adop C.R.O. AVIANO Baldo Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD ASSESSMENT OF DIFFERENT WHEAT CULTIVAR EFFECTS IN A MOUSE MODEL OF ENTEROPATHY Campania RIEGLER GABRIELE Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 269 di 356

270 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv ASSESSMENT OF THE PATHOBIOLOGICAL ROLE, DIAGNOSTIC AND PREDICTIVE VALUE OF THE NOVEL CYTOKINE IL 30 IN PROSTATE CANCER Abruzzo Di Carlo Emma Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Alloimmunity and infction: insight into pathogn drivn alloractivity to dvlop prvntiv stratgis for lat kidny graft failur SAN MATTEO COMOLI PATRIZIA Clinicoassistnzial Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Intimat Partnr Violnc and Woman's Mntal, Social and Physical Wll bing: analysis of risk factors and th bio bank for pigntic studis Liguria PIERLUIGI DANIELA Clinicoassistnzial Population Scincs and Epidmiology Bhavioral Gntics and Epidmiology BGES Idntification of nuclar micrornas affcting hmatopoitic and nuronal cll diffrntiation and tumorignsis Istituto Suprior di Sanita' Plosi Elvira Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Study of molcular mchanisms undrlying Altrnating Hmiplgia of childhood by a novl in vitro modl of human nuronal clls xprssing ATP1A3 gn mutations Lazio Gurriri Fiorlla Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurotransportrs, Rcptors, Channls and Calcium Signaling NTRC Artificial nural ntworks and risk stratification tools for syncop in th mrgncy dpartmnt Liguria Brignol Michl Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Scincs Small Businss SECS Circulating ndothlial prognitor clls as potntial prdictiv and prognostic markrs inmtastatic colorctal cancr patints Toscana CAPORALE ROBERTO Biomdica Oncology 2 Cancr Biomarkrs High dfinition Vido Thrmography (VTG): a nw mthod of imaging in paraclinical diagnosis of Non Mlanoma Skin Cancrs and in th "Skin Cancrization Fild" SAN GALLICANO LAINO LUIGI Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] INSECTS FOR FEED: EXPOSURE ASSESSMENT FROM FEED TO FOOD IZSPLV Marchis Danila Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 270 di 356

271 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Facilitating strok rcovry through hom basd rhabilitation training SANTA LUCIA Marangolo Paola Biomdica Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD In sarch of nw drugs and drug targts for th diagnosis and thrapy of Invasiv Fungal Infctions (IFIs) Istituto Suprior di Sanita' Sandini Silvia Biomdica Infctious Disass and Microbiology Pathognic Eukaryots PTHE Estimation of human halth risk to mthyl mrcury: hair and nail as noninvasiv bio indicators. IZSPLV Squadron Stfania Biomdica Vtrinary Food Safty FOSA Enginrd nanoparticls: potntial rol in inducing bronchial hyprrsponsivnss in xposd workrs. SAN RAFFAELE PISANA CALZETTA LUIGINO Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Molcular bass for th idntification of novl clinical approachs in patints with HPV inducd cancr REGINA ELENA Mariani Luciano Clinicoassistnzial Oncology 2 Cancr Biomarkrs Dvlopmnt of nw biguanids to targt cancr mtabolism IRCCS AOU San Martino IST (Gnova) Sambucti Gianmario Biomdica Oncology 1 Basic Tumor Cll Biology TCB Oropharyngal dysphagia in Myotonic Distrophis: diagnosis, managmnt and implications for clinical practic and rsarch CARLO BESTA Morandi Lucia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Prdicting chmothrapy toxicity in th ldrly: a prformanc assssmnt of xisting tools vs. aging biomarkrs in th Ligurian population Liguria Rptto Lazzaro Biomdica Oncology 2 Oncology CONC Prvnting mrgnc and transmission of multirsistant bactria in hospitalizd childrn: multi stratgy study of risk factors and ffctivnss of a tailord intrvntion OSPEDALE BAMBINO GESU' Ciofi dgli Atti Marta Luisa Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS ROLE OF THE IL 31/IL 31R AXIS IN B CELL MALIGNANCIES GASLINI Corcion Anna Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 271 di 356

272 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of th stromal drivd factor 1 (SDF 1)/CXCR7 crosstalk btwn human hpatic stllat clls (hhsc) and cholangiocarcinoma (CCA) clls: a nw targt for CCA thrapy? Toscana Gntilini Alssandra Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST Byond th clinical vidnc: a longitudinal study on th ffct of physical rhabilitation in th muscl synrgis and in functional brain activity in arly Parkinson Disas patints Toscana Luctti Claudio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Study of th HIV 1 cllular rsrvoir: impact of antirtroviral thrapy on HIV 1 DNA forms and idntification of archivd dfctiv viral variants. SAN MATTEO Paolucci Stfania Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Molcular and Cllular Biology AMCB NEUROPATHIC PAIN IN GAUCHER DISEASE TYPE 1: CLINICAL AND MOLECULAR ASPECTS Friuli Vnzia Giulia BEMBI BRUNO Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Survillanc of Multidrug Rsistant Organisms (MDROs) by a ntwork basd stratgy: tracking molcular pidmiology and outcoms through th Nonatal Intnsiv Car Units Sicilia Mammina Catrina Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Pr tratmnt Immun Activation/Exhaustion as a Factor Affcting Post cart Immun Rconstitution Lvl and Function in Naiv HIV infctd Prsons Undrgoing Tratmnt SPALLANZANI Martini Fdrico Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Patint drivd xnografts to xplor th usfulnss of prclinical modls on prsonalizd mdicin Emilia Romagna PANSINI Giancarlo Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Molcular scrning for a prsonalizd tratmnt approach in hpatocllular carcinoma. Campania Morisco Filomna Biomdica Oncology 1 Basic Molcular Oncognsis MONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 272 di 356

273 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th rol of multiparamtric Magntic Rsonanc Imaging in th slction of patints with nwly diagnosd prostat cancr at vry low risk suitabl for activ survillanc: a prospctiv multi institutional study Emilia Romagna Schiavina Riccardo Clinicoassistnzial Digstiv, Kidny and Urological Systms Urologic and Kidny Dvlopmnt and Gnitourinary Disass UKGD Towards saf, ffctiv and fasibl adoptiv T cll thrapy of solid tumors SAN RAFFAELE MILANO Mondino Anna Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Molcular profiling of EGFR mutant lung carcinoma through analysis of liquid biopsis PASCALE Normanno Nicola Clinicoassistnzial Oncology 2 Cancr Biomarkrs COmparativ Rsarch of Diffrnt Antithrombotic Stratgis in patints with acut coronary syndrom without prsistnt ST lvation, undrgoing coronary rvascularization (CORDAS Projct): outcoms rsarch and fficacy safty data. Emilia Romagna Cattabiani Maria Albrta Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Assssmnt of th rol of gns associatd with brast cancr prdisposition in th dvlopmnt of pdiatric cancrs ISTITUTO TUMORI MILANO Radic Paolo Biomdica Oncology 1 Basic Cancr Gntics CG Dp squncing and functional analysis of th mirnom in brast cancr progrssion: particular focus on xosoms, hypoxia and mir 328 Calabria Iuliano Rodolfo Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Prvntion of post hospital syndrom in ldrly through nutritional support Calabria Pujia Arturo Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Proprativ computr assistd planning and intraoprativ navigation in complx surgry of musculoskltal tumors RIZZOLI Ruggiri Pitro Clinicoassistnzial Oncology 2 Oncology CONC Dcoding th transcriptom of circulating msnchymal stm clls in patints with skltal disass and obsity. Vnto DALLE LUCA Biomdica Gns, Gnoms and CARBONARE GIUSEPPE Gntics Molcular Gntics MGA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 273 di 356

274 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Extracllular microrna in bronchoalvolar lavag for arly dtction of lung cancr IRCCS AOU San Martino IST (Gnova) Izzotti Albrto Biomdica Oncology 2 Cancr Biomarkrs Coming full circl on prnatal non invasiv gntic tsts: from halth tchnology assssmnt, through rcommndations for clinical practic/rsarch, to support for dcisions on covrag Emilia Romagna Ballini Luciana Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Crop biofortification with iodin: a nw tool to fight iodin dficincy disordrs. Toscana Tonacchra Massimo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F In vivo guidd rgnration of small diamtr artris (2 5 mm) using biodgradabl tubular scaffolds: rol of ndothlial prognitor clls in vasculognsis. Vnto Vindigni Vincnzo Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI PROJECT RANDOM: AXILLARY DISSECTION OR NOT IN SENTINEL NODE MACROMETASTASIS OF BREAST CANCER HUMANITAS tintrri corrado Clinicoassistnzial Oncology 2 Oncology CONC Manipulat cytokins to shift th chronic inflammatory ton inducd by prion disas as a rout to clinical thrapis HUMANITAS MATTEOLI MICHELA Biomdica Immunology Innat Immunity And Inflammation III Th inflammasom inducr IFI16, an alarmin that initiats and propagats inflammation in Inflammatory Bowl Disas and its rol as biomarkr of disas phnotyp htrognity and rspons to thrapy. SAN DONATO VECCHI MAURIZIO Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Saf Nanotchnology: Assssing Nanoparticl Toxicity of Environmntal Intrst by an Intgratd In Vitro Cll Basd Tst Stratgy. MAUGERI Coccini Trsa Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 274 di 356

275 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Epidmiology of Tinnitus in Italy using a Comprhnsiv Approach (ETICA) MARIO NEGRI Gallus Silvano Clinicoassistnzial Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME Prclinical valuation of Janus facd liposoms for th prvntion of infctious complications during immunomodulatory thrapy in autoimmun disass. Lazio Ria Francsco Biomdica Immunology Innat Immunity And Inflammation III Diffrnt NHERF1 subcllular localizations in brast cancr: could gntic and posttranslational altrations shd light on its us in clinical practic? ONCOLOGICO DI BARI Mangia Annita Biomdica Oncology 1 Basic Cancr Gntics CG camp PCT CGRP axis as a potntial molcular targt in th diagnosis and tratmnt of pr clampsia BURLO GAROFALO Radillo Oriano Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F Halth Tchnology Assssmnt and Comparativ Effctivnss Rsarch to apprais th ral world valu of an improvd pharmacognomics assay and of a mtabolic assay for prdiction of individual rspons to th anticancr agnt 5 Fluorouracil. Lazio SIMMACO MAURIZIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Gastric cancr in th ag of prcision mdicin: Linking gnomic altrations to targtd drug rspons to validat novl thraputic stratgis Istituto Oncologico Candiolo Comoglio Paolo Maria Biomdica Oncology 2 Cancr Biomarkrs TWIN ANALYSIS OF FINE NEEDLE ASPIRATION AND CIRCULATING TUMOR CELLS FOR GENOTYPE AND PHENOTYPE CHARACTERIZATION OF ADVANCED LUNG CANCER Toscana Mascalchi Mario Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 275 di 356

276 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Diagnostic validation of circulating micrornas as novl NSTEMI biomarkrs in old and vry old patints. I.N.R.C.A. Procopio Antonio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Changs in functional topography of th motor output aftr spinal cord injury SANTA LUCIA Cappllini Grmana Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Snsorimotor Intgration SMI A nw organizational modl for th managmnt of th diabtic foot ulcrs Sicilia Aliquo' Maria stlla Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Fatty Livr Scrning: Assssing th bst ffctiv scrning program for Non Alcoholic Fatty Livr Disas (NAFLD) Sicilia Camma Calogro Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Corrlation btwn gnotypic linags and pidmiological and clinical faturs of Mycobactrium tubrculosis infctions occurring in immigrant and authochtonous population living in th urban ara of Milan, Italy. Lombardia Franztti Fabio Clinicoassistnzial Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Dvlopmnt, tsting and dissmination of Communication stratgis and tools for vidnc basd Informd Dcision making in Italy (DCID.It) Lazio Parmlli Elna Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Hrpsvirus DNA in lowr rspiratory tract of intnsiv car unit patints: significanc and implications. Toscana Pris Adriano Biomdica Infctious Disass and Microbiology Virology A and B Study Sctions VIRA and VIRB An Animal Bhavior Analysis Systm xploiting th passiv RFID Tchnology in UHF band Istituto Suprior di Sanita' Di Giannuario Amalia Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral and Bhavioral Procsss Small Businss Activitis SBBB Gnomic analysis of human mdulloblastomas and prclinical gn thrapy study to targt th rgulation of crbllar prcursor migration Lazio Massimi Luca Biomdica Oncology 1 Basic Cancr Gntics CG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 276 di 356

277 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Improving chronic pain tratmnt using nw formulatd topical nanomdicins. Istituto Suprior di Sanita' Pirtti Stfano Biomdica Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Conncting DNA rpair and mtabolic altrations of obsity in a sarch for prdictiv biomarkrs Istituto Suprior di Sanita' Dogliotti Eugnia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO TP53 Polymorphisms in glioblastoma and Had & Nck cancrs: th clinical impact of corrlation btwn gnomic information and radio chmiothrapy tratmnt. Lombardia Buglion di Michla Biomdica Oncology 2 Monal Bastia Radiation Thraputics and Biology RTB Idntification of nw mtabolic thraputic targts of clar cll Rnal Cll Carcinoma cancr stm clls through th study of lipid and glucos mtabolism Lombardia Bovo Giorgio Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP charactrization and analytical confirmation of acut intoxications rlatd to nw psychoactiv substancs (NPS) of abus idntifid through th spcialist activity of a Poison Control Cntr: dfining a nw mrging public halth issu. MAUGERI Locatlli Carlo Alssandro Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Nw biomarkr for thrombotic strok in young patints: diagnostic and pathognic rol of anti phopsholipid antibodis (apl) spcific for bta2 glycoprotin I (B2GPI) Domain I AUXOLOGICO Mroni Pir Luigi Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun A pharmacogntic approach to sophagal cancr: constitutiv and somatic gntic variants as prdictiv, prognostic or disas risk markrs I. O. V. Saggioro Danila Clinicoassistnzial Oncology 2 Cancr Biomarkrs Exploring th suscptibility to fracturs in youth for its prvntion in adulthood: a phnotypic, functional and gnomic charactrization of bon fragility in childrn and adolscnts and thir familis. SAN RAFFAELE MILANO Mora Stfano Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 277 di 356

278 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dndritic clls nginrd with th transcription factors IRF1 and IRF8 as an innovativ tool for novl immunothrapy stratgis. Istituto Suprior di Sanita' Fragal Alssandra Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Early idntification of lft vntricular dysfunction du to anthracyclins and novl HER 2 targtd thrapis in adjuvant tratmnt of brast cancr: rol of nw imaging tchniqus and biomarkrs PASCALE Maura Nicola Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Intstinal microbiom in Parkinson's disas: idntification of disas biomarkrs along th gut brainaxis Provincia autonoma Trnto Malaguti Maria Chiara Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Dtcting "brain at risk" for Vascular Dmntia: th rol of potntial prclinical markrs from Transcranial Magntic Stimulation Sicilia Pnnisi Giovanni Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Capacitiv Coupling Elctric Filds (CCEF) in th Tratmnt of Vrtbral Comprssion Fracturs (VCFs) Puglia piazzolla andra Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Nuromlanin and iron dynamics in Parkinson s disas and othr synuclinopathis: invstigation of potntial nuroimaging markrs of nurodgnration and disas progrssion MONDINO Blandini Fabio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Prdicting th individual's potntial for functional rcovry in Multipl Sclrosis using a combind nuroimaging and clinical approach SANTA LUCIA Tomassini Valntina Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration HIGH RESOLUTION GENOMIC ANALYSIS AND BIOMARKER PROFILING OF AMYOTROPHIC LATERAL SCLEROSIS Sicilia La Blla Vincnzo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 278 di 356

279 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Bridging th gap btwn molcular mchanism and clinical trial, a promising approach to spinocrbllar ataxias sharing Purkinj nurons dark dgnration SAN RAFFAELE MILANO Casari Giorgio Nvio Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Rlationship btwn cognitiv function, typ 1 and typ 2 diabts Friuli Vnzia Giulia Candido Riccardo Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Rduction/limination of xposur to ionizing radiation in intrvntional lctrophysiologyprocdurs in childrn using tchnology basd on 3D mapping systms OSPEDALE BAMBINO GESU' Drago Fabrizio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Elctrical Signaling, Ion Transport, and Arrhythmias ESTA IMPROVEMENT OF PET 2 PROGNOSTIC IMPACT FOR A TAILORED THERAPY FOR HODGKIN LYMPHOMA Sicilia CONSOLI UGO Biomdica Oncology 2 Cancr Biomarkrs Utility of liquid biopsy in th managmnt of arly stag and advancd colorctal cancr (CRC) patints Sicilia BAZAN VIVIANA Biomdica Oncology 2 Cancr Biomarkrs PAIN ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH SUCCESSIVE NEURODEVELOPMENTAL INJURIES BURLO GAROFALO Bmbich Stfano Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Lvls of mirna from srum xosoms as potntial prdictiv biomarkrs of clinical outcom in pancratic ductal carcinoma patints ONCOLOGICO DI BARI Silvstris Nicola Biomdica Oncology 2 Cancr Biomarkrs Risk assssmnt for and stratgis to rduc prioprativ complications and organ damag for patints undrgoing cardiac surgry Friuli Vnzia Giulia Zcchin Massimo Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Mutations of cytochrom c associat with rspiration dfcts and pculiar altrations of apoptotic pathways: pathogntic implications in Thrombocytopnia 4 and Mylodysplastic Syndroms. SAN MATTEO PECCI ALESSANDRO Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 279 di 356

280 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nxt Gnration squncing in Midlin Dfcts associatd with hypopituitarism GASLINI Maghni Mohamad Clinicoassistnzial Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Tranxamic acid for hypracut primary IntraCrbral Hmorrhag Italy (TICH 2 Italy) Lombardia Ciccon Alfonso Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Rol of th Transglutaminas typ 2 (TG2) in th pathognsis of M. tubrculosis SPALLANZANI Piacntini Mauro Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Augmntation of nrv rgnration by iron oxid nanoparticls and lctromagntic fild: a study in rat mdian nrv lsion Toscana Rossi Bruno Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Dpicting common molcular mchanisms of livr and hart damag in ordr to improv diagnostic and thraputic managmnt of hpato cardio mtabolic syndrom in childrn OSPEDALE BAMBINO GESU' Nobili Valrio Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Association btwn svr psoriasis and subclinical athrosclrotic vascular damag ISTITUTO DERMOPATICO DELL'IMMACOLATA Mlillo Guido Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS PREDICTING FALLS AT HOME USING AN INTEGRATED ECG EMG EEG PAIN SENSORS (EEEPs) DETECTION SYSTEM NOT FALL Puglia DE MARINA Biomdica Emrging Tchnologis and TOMMASO Training in Nuroscincs Nurotchnology NT Un innovativ way to improv cancr patint outcoms. Th ffctivnss of a nurs ld tlphon follow up aftr thraputic cancr tratmnt. A randomizd controlld trial. Pimont Frigrio Simona Clinicoassistnzial Halthcar Dlivry and Mthodologis Nursing Scinc: Adults and Oldr Adults NSAA Prvntion of colorctal cancr with low dos aspirin and mtformin in high risk subjcts. Liguria D Cnsi Andra Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 280 di 356

281 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Impact of short trm fasting cycls on th fficacy of chmothrapy to trat pancratic cancr CASA SOLLIEVO SOFFERENZA Andriulli Anglo Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Nw thrapis for glioblastoma IRCCS AOU San Martino IST (Gnova) Frosina Guido Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Modulation of glycosphingolipid mtabolism for nhancing cll rsistanc to hypoxic strss: a nw possibl thraputic approach for ischmic cardiovascular disass SAN DONATO Mnicanti Lornzo Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Nw radiolabld thranostic agnts targting molcular pathways rsponsibl for mtastatic sprad PASCALE Aloj Luigi Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Early Onlin Rhabilitation of Dvlopmntal Dyslxia: a randomizd clinical study BURLO GAROFALO Lonciari Isablla Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Rmot controlld monitoring and clinical clustring of gait and postur disordrs in Parkinson Disas: an ovrlapping modl inst btwn individual falls rmitting and social rlapsing. Lazio Pirantozzi Mariangla Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Antimicrobial stwardship and dvlopmnt of nw laboratory procdurs to assss biofilm production and drug rsistanc for nosocomial survillanc and prvntion of halthcar associatd infctions SAN GALLICANO PRIGNANO GRAZIA Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Inducd Pluripotnt Stm Clls from schizophrnic patints as platforms for disas modling and for undrstanding th molcular and cllular basis of rfractorinss to clozapin tratmnts. Lombardia Scaron Silvio Biomdica Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS A prospctiv randomizd phas II III study of continuous vrsus intrmittnt Dabrafnib and Tramtinib thrapy in BRAFV600 mutatd mtastatic mlanoma patints: clinical fficacy and translational rlvanc Lombardia Mandala Mario Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 281 di 356

282 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Tailord chmothrapy basd on biomarkrs xprssion in malignant plural msothlioma IRCCS AOU San Martino IST (Gnova) Grossi Francsco Clinicoassistnzial Oncology 2 Oncology CONC Small Intstinal Bactrial Ovrgrowth (SIBO) syndrom in Multipl Sclrosis (MS) patints and strok survivors. Umbria COREA FRANCESCO Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Cancr Rhabiltation: dfinition of a multidimnsional and multidisciplinary approach. Patint mpowrmnt and Cost analysis. REGINA ELENA Pac Andra Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Molcular charactrization of lobular carcinoma of th brast and its variants. Emilia Romagna FOSCHINI MARIA PIA Clinicoassistnzial Oncology 1 Basic Cancr Molcular Pathobiology CAMP A study of th molcular and cllular mchanisms inducd by macronvironmnt (nrichd nvironmnt) on tumor micronvironmnt of xprimntal mous glioma NEUROMED Limatola Cristina Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Combining immunomodulatory drugs with standard chmothrapy to rvrt tumor promoting Th2 inflammation in pancratic cancr SAN RAFFAELE MILANO Protti Maria Pia Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Prvalnc of infctions in prgnancy among immigrant compard to rsidnt mothrs: ffct of th inappropriatnss of prnatal car on th incidnc, svrity and long trm outcoms of congnital infctions in ach group's babis. OSPEDALE BAMBINO GESU' Auriti Cinzia Clinicoassistnzial Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Unravling th molcular basis of icosapntanoic acid (EPA) ffcts on nural dvlopmnt and nurodgnration Istituto Suprior di Sanita' VITELLI LUIGI Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 282 di 356

283 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idiopathic Parkinson Disas diagnosis and pathognsis: th sarch for rliabl biomarkrs Istituto Scinz Nurologich Donadio Vincnzo Anglo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration INHIBITION OF DRUGGABLE GENE ABERRATIONS IN ER POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Emilia Romagna Frassoldati Antonio Clinicoassistnzial Oncology 2 Oncology CONC Inhibition of dyskrin as a nw approach to targt ribosom biognsis and cancr cll growth Emilia Romagna Montanaro Lornzo Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP PHARMACOLOGICAL ACTIVATORS OF TMEM16A AND SLC26A9 CHLORIDE CHANNELS TO POTENTIATE MUCOCILIARY CLEARANCE AND INNATE DEFENSE MECHANISMS IN HUMAN AIRWAY DISEASES GASLINI Galitta Luis Juan V Biomdica Cll Biology Mmbran Biology and Protin Procssing MBPP Molcular charactrization of pulmonary sarcomatoid carcinoma, a dadly subtyp of lung cancr, for patint managmnt ISTITUTO TUMORI MILANO Plosi Giuspp Clinicoassistnzial Gns, Gnoms and Gntics Molcular Gntics MGA Cost analysis of managmnt of ldrly sub acut strok patints in Italy; halthcar costs rduction and quality lif bnfits on strok patints using a ICT program of th trtiary prvntion of cognitiv dclin and motor function through cognitiv fun SAN RAFFAELE PISANA DEL PERCIO CLAUDIO Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurophysiology, Dvics, Auditory Dvics and Nuroprosthsis Small Businss SBNE Cancr survivorship: xtnsion of th italian mdicalpsychosocial paradigm to prsons with activ disas undr thraputical control. C.R.O. AVIANO Tirlli Umbrto Clinicoassistnzial Oncology 2 Oncology CONC Validation of novl assays to dtrmin HIV nutralization and to masur th virus rsrvoir, ky biomarkrs of thraputic fficacy and clinical outcom, for us in th clinical practic SAN GALLICANO Ensoli Fabrizio Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 283 di 356

284 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nuropptid Y as rgulator of macrophag phnotyp and functions: a nuroimmun cu in athrosclrosis rgrssion? Istituto Suprior di Sanita' Buttari Brigitta Biomdica Immunology Innat Immunity And Inflammation III Biomarkrs of rspons to tratmnt in myasthnia gravis CARLO BESTA Antozzi Carlo Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun Tissu protomics and SILAC basd quantitativ protomic analysis of scrtom of bnign and malignant parathyroid tumors: idntification of molcular and biochmical biomarkrs for arly diagnosis of parathyroid cancr. Toscana Ctani Filomna Biomdica Oncology 2 Cancr Biomarkrs MicroRNAs in xhald brath condnsat and plasma: novl non invasiv biomarkrs for nonsmall cll lung cancr diagnosis. MAGGIORE Psatori Angla Ccilia Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP NETosis in athrothrombotic disordrs Vnto Paultto Paolo Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Dvlopmnt of diagnostic tools for foodborn viruss dtction in outbrak sttings: rapid scrning mthods and high throughput squncing for a comprhnsiv rspons IZSLER Losio Marina Nadia Biomdica Vtrinary Food Safty FOSA Epigntics Mts Mtabolomics: A Novl Diagnostic and Thraputic Approach in Hart Failur Campania Prrino Cinzia Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Validation of a novl non invasiv tchniqu basd on ral tim ultrasound B mod to assss th jugular vnous puls Emilia Romagna Zamboni Paolo Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 284 di 356

285 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv COULD AN HOME BASED LONG TERM TELEMEDICINE PROGRAMME BE FEASIBLE AND REDUCE CARDIOVASCULAR RISK IN PATIENTS WITH METABOLIC SYNDROME? MAUGERI Scalvini Simontta Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Functional intrplay btwn mtabotropic glutamat and nicotinic rcptors in th modulation of plastic changs of striatal dopamin rlas: implications for Parkinson's Disas. SANTA LUCIA Mrcuri Nicola Biagio Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T HIV 1 rgulatory protin Nf can contribut to incrasing suscptibility to malaria and opportunistic infctions in primary human macrophag through modulation of class B scavngr rcptor CD36 xprssion. Istituto Suprior di Sanita' Elonora Olivtta Biomdica AIDS and Rlatd Rsarch AIDS Associatd Opportunistic Infctions and Cancr AOIC Ergot alkaloids in crals: occurrnc, ffct of procssing and xposur assssmnt of th Italian consumr Istituto Suprior di Sanita' D Santis Barbara Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Angiognsis impairmnt in diabts: rol of Nuclophosmin HMGB1 intraction ISTITUTO DERMOPATICO DELL'IMMACOLATA Di Carlo Anna Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Nitrosation of pharmacuticals of clinical us in humans: mchanism of transformation in human saliva at th acidic ph of th stomach, and valuation of th associatd potntial gnotoxic and carcinognic risk. Istituto Suprior di Sanita' Pitrafort Donatlla Biomdica Oncology 1 Basic Cancr Etiology CE Dvlompmnt of an innovativ 3D dynamic cultur modl in Bioractor to b usd as a surrogat Multipl Myloma micronvironmnt for th invstigation of tumor biology and th assssmnt of patint spcific rspons to drugs SAN RAFFAELE MILANO Frrro Elisabtta Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Assssmnt of th diagnostic valu of novl protomic biomarkrs within salivary microvscicls for th arly non invasiv diagnosis of primary Sjögrn s syndrom Toscana Baldini Chiara Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 285 di 356

286 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Prvalnc and burdn of chronic hpatitis C virus infction in Italy: a rprsntativ nationwidstudy in th gnral population. Istituto Suprior di Sanita' Spada Ena Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS A longitudinal study on muscl synrgis during walking in sub acut strok prsons: rol of rcovry and rhabilitation DON GNOCCHI Frrarin Maurizio Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Ostopontin and ICOS/B7h signaling pathways as possibl targts for novl thraputic stratgis in psoriasis GALEAZZI Altomar Gianfranco Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Primat to human cross spcis transmission of simian Typ D rtrovirus (SRV): sroprvalnc study in Italian cohorts. Istituto Suprior di Sanita' Maggiorlla Maria Trsa Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS An approach basd on AZP531, th unacylatd ghrlin (UnAG) analogu, to improv blood flow and support skltal muscl rgnration in diabts and priphral artry disas (PAD). Pimont Dntlli Patrizia Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Idntification of biological faturs accounting for priphral T cll lymphomas pathognsis and rfractorinss to Romidpsin in association with anthracyclin basd combination chmothrapy ISTITUTO TUMORI MILANO Corradini Paolo Clinicoassistnzial Oncology 2 Oncology CONC Noadjuvant pptid rcptor radionuclid thrapy (PRRT) with 90Y DOTATOC in pancratic nurondocrin tumors. I.E.O. Bodi Lisa Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Infantil mitochondrial lukoncphalopathis: charactrization of nw phnotyps and idntification of novl disas gns CARLO BESTA Moroni Isablla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD MicroRNA rgulation in th pathognsis of MD and in th mchanism of action ofantidprssant drugs FATEBENEFRATELLI Bocchio Luislla Biomdica Gns, Gnoms and Chiavtto Gntics Molcular Gntics MGA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 286 di 356

287 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nw Halthcar Nano/Micromatrials for Paint and Floors Coatings Istituto Suprior di Sanita' Stringaro Annarita Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Study of nw biomarkrs for diagnoss of disordrs of bil acid synthsis by mass spctromtry and mtabolomics approach. Vnto GIORDANO GIUSEPPE Biomdica Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP A nw insight into th rol of aging in smoking rlatd disass: a study of cll snscnc and inflammation in Chronic Obstructiv Pulmonary Disas (COPD) and Idiopathic Pulmonary Fibrosis (IPF) Vnto Satta Marina Biomdica Cardiovascular and Rspiratory Scincs Lung Cllular, Molcular, And Immunobiology LCMI Effcts of Tumor associatd Fibroblasts and tumor clls on th availability of fficint NK clls within th tumor cor: charactrization of molcular targts for thrapy in mlanoma and colon cancr IRCCS AOU San Martino IST (Gnova) Vital Massimo Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Idntification of novl biomarkrs prdictiv of rspons to mitotan in patints with adrnocortical carcinoma to implmnt a prsonalizd adjuvant tratmnt. Pimont Trzolo Massimo Biomdica Oncology 2 Cancr Biomarkrs Mlanoma progrssion: idntification of nw pigntic, druggabl candidats of tumor growth in vivo. I.E.O. LANFRANCO LUISA MARIA Biomdica Oncology 1 Basic NE Molcular Oncognsis MONC CarToy: a smart Systm for arly hom basd intrvntion in infants at high risk for Crbral Palsy STELLA MARIS Cioni Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Nurogn origin of hyprtnsion in hmodialytic patint: morphomtric study of rnal sympathtic innrvation, its pathogntic rol and fficacy of rnal bilatral dnrvation. Lazio MAURIELLO ALESSANDRO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Evaluation of bis maltolats, a novl class of maltoldrivd compounds, as novl thraputic tool for th tratmnt of high risk mylodysplastic syndrom (MDS) as singl agnts or in combination with DNA dmthylating drugs. March Loni Pitro Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 287 di 356

288 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nw mthodologis for oncologic diagnostic in thyroid cancr Toscana Vitti Paolo Biomdica Oncology 2 Cancr Biomarkrs USE OF LABELED MESENCHYMAL STEM CELLS AS DELIVERY VECTORS OF ANTI CANCER DRUGS Istituto Suprior di Sanita' Hassan Hamisa Jan Biomdica Oncology 2 Dvlopmntal Thraputics DT Cardiovascular risk and gntic hyprcholstrolmias: improving risk assssmnt to optimiz tratmnt Sicilia Avrna Maurizio Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD For patints' sak: how rsarch translats into practic. A study on th impact of publicly fundd halth rsarch Emilia Romagna Addis Antonio Clinicoassistnzial Halthcar Dlivry and Mthodologis Rsarch on Ethical Issus in Human Studis REHS FOLLOW UP OF NEOPLASTIC CASES IN SENTINEL ANIMALS LIVING IN THE TERRITORY SO CALLED TERRA DEI FUOCHI IN CAMPANIA REGION IZSME dgli Ubrti Barbara Biomdica Oncology 1 Basic Cancr Etiology CE Rhabilitation for bdriddn patints: incrasing prformanc and appropriatnss by mans of cognitiv and autonomic data analysis Istituto Suprior di Sanita' D'Avnio Giuspp Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Snsorimotor Intgration SMI Pr clinical dvlopmnt of radiolablld nanoparticls for molcular imaging of angiognsis Toscana Pupi Albrto Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Molcular Imaging and Prob Dvlopmnt CMIP Targting protin actylation for non small cll lung cancr thrapy: opportunitis to ovrcom drug rsistanc REGINA ELENA Trisciuoglio Danila Biomdica Oncology 2 Drug Discovry and Molcular Pharmacology DMP A packaging sirna nanothraputic approach addrssing a causal dfct of dopaminrgic nurons to arrst nigrostriatal dgnration in xprimntal Parkinson's disas Associazion Oasi Maria SS Marchtti Bianca Maria Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration An intgratd modl of multidisciplinary tools to targt th practic of prsonalizd mdicin in rhumatoid arthritis Emilia Romagna Salvarani Carlo Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 288 di 356

289 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Modulating sizur xprssion and brain damag with convntional and innovativ thraputic stratgis in a rat modl of human cortical dysplasia CARLO BESTA Colciaghi Francsca Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Rgulation and rol of CCAR2 in DNA damag rspons and brast cancr progrssion ISTITUTO TUMORI MILANO Dlia Domnico Biomdica Oncology 1 Basic Tumor Cll Biology TCB Dcrasing nuronal cll loss in Parkinsonisms by idntifying stm cll mdiatd rparativ mchanisms: a pilot study in Progrssiv Supranuclar Palsy. MAGGIORE Giordano Rosaria Biomdica Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Cardio rspiratory ffcts in rlation to cigartt us: building a clinical and pidmiological nation wid knowldg bas Sicilia Polosa Riccardo Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Olic acid countracts cathpsin B rlatd aggrssivnss of mtastatic mlanoma Istituto Suprior di Sanita' Mattia Gianfranco Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM Long trm vs short trm survivors patints with Malignant Plural Msothlioma: molcular markrs, scrtom and xom analysis Toscana CRISTAUDO ALFONSO Biomdica Oncology 2 Cancr Biomarkrs IODINE NUTRITIONAL STATUS IN NEWBORNS AND CHILDREN 1 5 YEARS OLD: A STRATEGY TO REDUCE IODINE DEFICIENCY IN HIGH RISK CATEGORIES OF THE POPULATION GASLINI GASTALDI ROBERTO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Cration and implmntation of an intgratd ntwork for th managmnt of diabtic foot Sicilia TRAPANI VINCENZO PIO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Immunologic biomarkrs for clinical and thraputic managmnt of Autoimmun disass SAN GALLICANO TRENTO ELISABETTA Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 289 di 356

290 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Cholin mtabolism assssd by Fluorocholin Positron Emission Tomography for monitoring th rspons to trastuzumab in advancd brast cancr I. O. V. Crvino Anna Rita Clinicoassistnzial Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Axillary Rvrs Mapping (ARM).Try to idntify and spar lymphatic pathways in brast cancr surgry to prvnt brast cancr rlatd lymphdma (BCRL) Emilia Romagna CARCOFORO PAOLO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT How a multi organ (Hart, Thyroid, Kidnys) multimarkr stratgy may improv risk prdiction in childrn undrgoing cardiac surgry: a modl to prov that biomarkrs in pdiatric cardiac surgry ar not mystrious but usful tools. Toscana Simona Storti Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Enriching young popl with Intllctual Disability Disordr: prsonalizd tlrhabilitation programs vrsus ordinary car. STELLA MARIS bargagna stfania Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Intrfron rgulatory factor 4 (IRF4) in chronic lymphocytic lukmia: functional, prognostic and thraputic implications Emilia Romagna MARASCA ROBERTO Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP DEVELOPMENT AND IMPLEMENTATION OF NEW TOOLS FOR THE VERIFICATION AND CONTROL OF THE EFFECTIVENESS OF INTERVENTIONS IN PERSON WITH SPINAL CORD INJURY SANTA LUCIA Scivoltto Giorgio Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Study of th intractions btwn lntiviruss and transposabl lmnts Istituto Suprior di Sanita' Ridolfi Barbara Biomdica AIDS and Rlatd Rsarch AIDS Molcular and Cllular Biology AMCB ROLE OF THE ACVR1 GENE AND THE BMP PATHWAY IN PEDIATRIC ASTROCYTIC TUMORS GASLINI Ravazzolo Robrto Biomdica Oncology 1 Basic Cancr Gntics CG , diagnostic, pharmacological and pharmacogntic managmnt of Gambling disordr in Calabria, Italy. A prospctiv study. Calabria galllli luca Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 290 di 356

291 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv IS THERE A SYNERGYSM BETWEEN HEAD PAIN AND PELVIC PAIN IN WOMEN? THE CASE OF MIGRAINE AND ENDOMETRIOSIS A CLINICAL, NEUROPHYSIOLOGIC AND PHARMACOGENOMIC STUDY. SAN MATTEO Nappi Rosslla Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Pathognsis of Shiga toxin producing Eschrichia coli infctions: study of th kintics of Shiga toxins in th blood of infctd patints with bloody diarrha (hmorrhagic colitis) and/or hmolytic urmic syndrom, aimd at bttr undrstanding th mod Istituto Suprior di Sanita' scavia gaia sofia Biomdica Infctious Disass and giusppina Microbiology maria Host Intractions with Bactrial Pathogns HIBP Lipidomics and protomics of th skin prmability barrir vrsus blood lipidom/sphingolipidom towards th idntification of novl candidats involvd in th barrir disruption and th dsign of innovativ diagnostic tools and tratmnts in atopic drma SAN GALLICANO CAMERA EMANUELA Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Th implmntation of a nw stratgy to tailor mammography scrning population to diffrnt pattrns of brast cancr risk. Lombardia Frammartino Brunlla Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Fighting drug rsistanc in tripl ngativ brast cancr (TNBC): a combinatorial approach basd on anti Kit ligand vaccination Pimont Brizzi Maria Flic Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Epigntic and molcular mchanisms involvd in th onst/progrssion of vulvar lichn sclrosus and vulvar squamous cll carcinoma. Emilia Romagna Martini Frnanda Biomdica Oncology 1 Basic Molcular Oncognsis MONC SYSTEMIC AND MUCOSAL CORRELATES OF PROTECTION IN HIV EXPOSED SERONEGATIVE INDIVIDUALS (HESN) Lombardia Gori Andra Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Idntification of novl molcular mchanisms and implmntation of nw diagnostic tools for growth disordrs, invstigatd by using high throughput gnom approachs AUXOLOGICO Finlli Palma Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 291 di 356

292 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Ultrasound on bioffcts and safty: an intgratd approach in valuating ultrasound mdiatdcll altrations at both cll mmbran and gntic lvl Chss producd from raw milk: ffct of hat tratd milk on safty, charactristic organolptic and nutritional proprtis Gnom wid Association study to valuat gntic risk factors for SPlanchnic vnousthrombosis (GASP Study) INAIL Bdini Anglico Biomdica Cll Biology Mmbran Biology and Protin Procssing MBPP IZSLER Daminlli Paolo Biomdica Vtrinary Food Safty FOSA MAGGIORE Bucciarlli Paolo Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Ingstibl capsul for photodynamic tratmnt of Hlicobactr pylori infction Toscana Orsini Barbara Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Complianc to clinical guidlins for pithlial ovarian cancr in rlation to patint outcom. A populationbasd clinical audit in th Pidmont Rgional Cancr Ntwork Pimont Zola Paolo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD SAFETY AND EFFICACY OF PHYTOSOMIAL CURCUMIN IN NON ALCOHOLIC FATTY LIVER DISEASE: A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL. Pimont GAMBINO Robrto Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Gn ntworks controlling motor nuron dgnration in spinal muscular atrophy for th dvlopmnt of nw thraputic stratgis: a comparativ transcriptomic approach basd on inducd pluripotnt stm clls and mous modls MARIO NEGRI GARATTINI ENRICO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Rol of havy mtals in th onst and progrssion of human gastrointstinal inflammation Campania Cuomo Rosario Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 292 di 356

293 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Immunological radication of minimal rsidual disas in multipl myloma by chckpoint blockad and unlashing anti tumor immun rsponss Pimont Massaia Massimo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII EMERGING ONCOGENIC PAPILLOMAVIRUS AND POLYOMAVIRUS IN WATER ENVIRONMENTS: A COMPREHENSIVE APPROACH TO ASSESS THE POTENTIAL FOR WATERBORNE TRANSMISSION Istituto Suprior di Sanita' La Rosa Giusppina Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Radiation Inducd abscopal/bystandr Effcts (RIBEs) upon Strotactic Body RadioThrapy (SBRT) in oligomtastatic patints: idntification of th molcular/cllular playrs involvd REGINA ELENA Bossi Gianluca Clinicoassistnzial Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Klbsilla pnumonia carbapnmass (KPCs) positiv strains in hospitalizd patints non rspondrs to antibiotic thrapy and without any othr thraputic option: valuation of a rscu thrapy basd on facalmicrobiota transplantation (FMT). SAN MATTEO BRUNO RAFFAELE Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Phas II trial of carfilzomib and lnalidomid basd tratmnt for transplant ligibl and non ligibl nwly diagnosd patints with primary plasma cll lukmia: a total thrapy modl with focus on prognostic rol of gnomic signatur. CROB Musto Pllgrino Biomdica Oncology 2 Oncology CONC OLEUROPEIN FOR TREATMENT OF ULCERATIVE COLITIS: FROM BENCH SIDE TO CLINICS. Calabria Luzza Francsco Biomdica Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG MicroRNAs as plasma biomarkrs of carotid plaqu instability Vnto Scuro Albrto Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 293 di 356

294 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Gn xprssion profil of priphral nrvs in patints with Amyotrophic Latral Sclrosis. SAN RAFFAELE MILANO Quattrini Anglo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Human adipos msnchymal stm clls trasplantation in dgnrativ disc disas: in vitro and invivo study of th molcular mchanism involvd in immunomodulation and cll rcovry. CARLO BESTA Frri Anna Lucia Biomdica Bionginring Scincs Maria and Tchnologis Gn and Drug Dlivry Systms GDD Psudoviral Immunity and Podocyt strss protins in Lupus Erithmatosus. From 'in vivo' rsarch on autoantibodis to mchanisms GASLINI Bruschi Maurizio Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Molcular targting of Notch signaling as a novl thraputic stratgy for multipl myloma tratmnt MAGGIORE Nri Antonino Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Dvlopmnt of a modl for quantitativ risk assssmnt of tick born disass in Italian city parks Istituto Suprior di Sanita' Vscio Maria Fnicia Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP Mtabolomic profil of abdominal adipos tissu as a tool to idntify th ffct of ndocrin disruptors in human obsity: a potntial clu for diagnostic and thraputic approach. AUXOLOGICO Marzullo Paolo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Myo inositol in th prvntion of gstational diabts in womn at high risk. A multicntric, randomizd, doublblind, placbo controlld study. Sicilia D'Anna Rosario Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN GERIATRIC ASSESSMENT IN THE ONCOLOGY SETTING: VALIDATION OF A MULTIDIMENSIONAL PROGNOSTIC INDEX Emilia Romagna INDELLI MONICA Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 294 di 356

295 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Safty, immunognicity and fficacy of vaccinations against Influnza, Pnumococcus, Hpatitis B, Papillomavirus and Hrps Zostr in patints with autoimmun disass undr immunosupprssiv tratmnt Lazio D'Amlio Raffal Clinicoassistnzial Immunology Vaccins Against Microbial Disass VMD Radiation xposur optimization by wirlss tchnology for profssionals involvd in th managmnt and car of patints undrgoing thrapy with radionuclids. Implmntation of nvironmntal monitoring. CROB Storto Giovanni Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Dvlopmnt and implant of th photovoltaic artificial rtina in th pig with photorcptor dgnration: towards th human Phas 1 xprimntation Vnto Prtil Grazia Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI RESPIRATORY GATED DEEP INSPIRATION BREATH HOLD AND SURFACE IMAGING FOR RADIOTHERAPY OF LEFT SIDED BREAST CANCER Pimont Krngli Marco Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Enhancmnt of mir 34a mdiatd nurognsis as novl thraputic approach for aging and nurodgnration Istituto Suprior di Sanita' MERLO DANIELA Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Prospctiv Appraisal of Th Prvalnc of Primary Aldostronism in HYprtnsiv Patints Prsnting with Lon Atrial Fibrillation (PAPPHY Study): Undrstanding Th Mchanisms To Optimiz Th Diagnosis. Vnto Rossi Gian Paolo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Th tumorignic potntial of cancr stm clls and th influnc of inflammasom activation in th pathophysiology of cholangiocarcinoma. March Bndtti Antonio Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Pulmonary infctions by Psudomonas aruginosa in a third lvl padiatric univrsity hospital: study of mchanisms involvd in adaptation, virulnc, transmission, dvlopmnt of antibiotic rsistanc Toscana CAMPANA SILVIA Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 295 di 356

296 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Angiognic and anti angiognic factors in childrn with Infantil Hamangioma: how thy chang undr tratmnt with oral propranolol. Nw thraputic options for nwborns with rtinopathy of prmaturity Toscana d Martino Maurizio Biomdica Vascular and Hmatology Vascular Cll and Molcular Biology VCMB Toscana Filippi Luca Biomdica Cll Biology Biology and Disass of th Postrior Ey BDPE Transcranial dirct currnt stimulation (tdcs) and spch thrapy in Primary Progrssiv Aphasias (PPA) FATEBENEFRATELLI Cotlli Maria Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Tlstrok plus hom tlmonitoring projct. Fasibility, rliability, impact on quality of car and halth costs of a nodal tlmdicin ntwork for a non stop monitoring of strok patints from th acut to th chronic phas of th disas. MONDINO Cavallini Anna Maria Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Th paradox of prsistnt 5 alpha rductas inhibition by finastrid: a modl of nuropathy and a pharmacogntic approach Emilia Romagna Simoni Manula Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE EARLY START EXERCISE TRAINING AFTER ACUTE HEMODYNAMIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE. A RANDOMIZED, CONTROLLED TRIAL ON FEASIBILITY AND SHORT AND MEDIUM TERM IMPACT ON FUNCTIONAL CAPACITY, SYMPTOMS AND REHOSPITALIZATIONS. MAUGERI Mzzani Alssandro Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Food safty of bivalv molluscs: Dvlopmnt and application of molcular tools for idntification, quantification and valuation of antibiotic rsistanc and virulnc potntial of food associatd ntric and autochthonous bactrial pathogns IZSUM Loni Francsca Biomdica Vtrinary Food Safty FOSA Mutational analysis of Hdghog signaling pathway gns in basal cll carcinomas from tacrolimus/cyclosporintratd rnal transplant rcipints Pimont Boldorini Rnzo Luciano Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 296 di 356

297 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv MOLECULAR AND SEROLOGICAL SURVEY FOR EMERGING ENTERIC VIRUSES WITH ZOONOTIC POTENTIAL IN WILD ANIMALS IN ITALY IZSPLV ORUSA RICCARDO Biomdica Vtrinary Animal Halth ANHE DIAMOND (DIt, Activity and MONitoring): a prsonalizd lifstyl intrvntion trial for brast cancr patints. I.E.O. Titta Lucilla Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP Xnotransplantation of primary cancr sampls in zbrafish mbryos: towards prsonalisd mdicin Toscana Morlli Luca Clinicoassistnzial Oncology 2 Oncology CONC Mtallothionins as prdictiv biomarkrs for cardiovascular vnts in patints with svr carotid or priphral athrosclrosis I.N.R.C.A. Giacconi Robrta Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Nw tchnologis for a prdictiv, prsonalizd, prvntiv and participatory (4P) mdicin in atrial fibrillation Istituto Suprior di Sanita' Giovanni Calcagnini Biomdica Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Dvlopmnt of an in vitro modl systm basd on clonal amniotic fluid stm clls for disscting th pigntic mchanisms undrlying pathognsis of Kabuki syndrom MAGGIORE Lazzari Lornza Biomdica Biology of Dvlopmnt and Aging Cllular Mchanisms in Aging and Dvlopmnt CMAD THE MEVALONATE PATHWAY AND CXCR4 SIGNALING CROSS TALK IN CHRONIC LYMPHOCYTIC LEUKEMIA: A TARGET TO OVERCOME FLUDARABINE RESISTANCE? Pimont coscia marta Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Early and lat graft failur in livr transplantation: impact of pr formd and d novo spcific antibodis, dfinition of histological damag and antibodis mdiatd failur and nw immunosupprssion stratgy to prvnt antibodis graft failur Emilia Romagna BONTADINI ANDREA Clinicoassistnzial Immunology Transplantation, Tolranc and Tumor Immunology TTT Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 297 di 356

298 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of Mycobactrium avium subspcis paratubrculosis (Map) as a triggr in Typ 1 Diabts, Hashimoto Thyroiditis and Multipl Sclrosis Sardgna Schi Lonardo Biomdica Infctious Disass and Antonio Microbiology Host Intractions with Bactrial Pathogns HIBP CARDIOGEN DECODER: Intrprtation of clinical, pathologic, imaging and gntic big data in a larg population of gnotypd hritabl cardiomyopathis. SAN MATTEO ARBUSTINI ELOISA Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Prsonalizd molcular mdicin in patints with dfind and undiffrntiatd autoinflammatory disass: a rational approach. GASLINI Gattorno Marco Clinicoassistnzial Immunology Innat Immunity And Inflammation III Charactrisation of basal and post absorptiv Glucagon Lik Pptids scrtory profil in patints with Mtabolic Syndrom and Inflammatory Bowl Disas SAN MATTEO Lucotti Pitro Carlo Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Extracllular matrix (ECM): nw stratgis for diagnostic, thraputic and clinical car in Oncology Vnto Agostini Marco Biomdica Oncology 2 Cancr Biomarkrs Novl 2D and 3D human modls of cardiornal pathophysiology and drug discovry Vnto GEROSA GINO Biomdica Bionginring Scincs and Tchnologis Modling and Analysis of Biological Systms MABS DEVELOPMENT AND CLINICAL APPLICATION OF A NOVEL RADIOGUIDED SURGERY TECHNIQUE IN BRAIN TUMORS CARLO BESTA Frroli Paolo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Small Businss Bionginring, Surgical Scincs, and Tchnology SBTS (SBIR/STTR) Dtction of vctor born viruss in Sardinia by mtagnomics and valuation of Blutongu virus volution Endocannabinoids and growth factors cross talk in th procss of wound haling IZSAM Savini Giovanni Biomdica Vtrinary Animal Halth ANHE SAN GALLICANO Cardinali Giorgia Biomdica Cll Biology Molcular and Intgrativ Signal Transduction MIST Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 298 di 356

299 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Gntic and pigntic mchanisms in Clustr Hadach: gnomic and plasma xosom mirna studis Emilia Romagna Pini Luigi Albrto Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration TOWARDS A PRECISION MEDICINE APPROACH TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE SAN MATTEO Luistti Maurizio Biomdica Cardiovascular and Rspiratory Scincs Rspiratory Intgrativ Biology and Rsarch RIBT EPIDEMIOLOGICAL, CLINICAL AND MOLECULAR CHARACTERIZATION OF POST TRANSPLANT MALIGNANCIES: IMPLICATIONS FOR CANCER PREVENTION AND PROGNOSIS IN RECIPIENTS OF KIDNEY AND LIVER TRANSPLANTS C.R.O. AVIANO Srraino Digo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Xno fr nural crst drivd human stm clls from oral tissu as a nw tool for th modling and tratmnt of Multipl Sclrosis: towards prsonalizd mdicin in nuroinflammatory/nurodgnrativ disordrs. Abruzzo Lugarsi Alssandra Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Nurodiffrntiation, Plasticity, and Rgnration NDPR Myofibr micronvironmnt intraction as a triggr and a thraputic targt for muscl wasting in cancr cachxia. Lazio MUSCARITOL MAURIZIO Biomdica Musculoskltal, Oral and I Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Immun chckpoints blockad and pigntic immunomodulation: a novl thraputic approach in malignant msothlioma Toscana Calabro' Luana Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII A novl structural and functional MRI drivd indx of axonal mylination: application to MS and corrlation with nurophysiology SANTA LUCIA Crcignani Mara Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Improving Diagnostic and Thraputic Pathway in Ovarian Cancr: taking advantag of a spcializd rfrral cntr. C.R.O. AVIANO SORIO ROBERTO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 299 di 356

300 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exom squncing to idntify nw disas gns for Essntial Trmor Sicilia Aridon Paolo Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Markrs and Biofilm Rlatd Infction DiaGnostic Evolution [M BRIDGE]: dvlopmnt of a nw platform for prosthtic and joint infctions GALEAZZI Drago Lornzo Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Prsonnl and workrs with pacmakr or implantabl dfibrillator in th MRI nvironmnt: mthods and xprimntal data collction for th risk assssmnt Istituto Suprior di Sanita' Trivnti Michl Biomdica Halthcar Dlivry and Mthodologis Community Lvl Halth Promotion CLHP Multilinag diffrntiation of limbal stm clls for rgnrativ mdicin. Sicilia GIORDANO CARLA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Capturing human amniotic msnchymal stromal cll (hamsc) drivd ky ffctors that induc protction aftr traumatic brain injury MARIO NEGRI Roncati Zanir Elisa Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Disscting th rol of th B cll rcptor rgulatd mir 132/212 clustr in mdiating anrgy and apoptosis in normal and malignant B clls C.R.O. AVIANO Gatti Valtr Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Molcular profiling of myloid noplasms for dvloping innovativ prcision mdicin stratgis SAN MATTEO CAZZOLA MARIO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Spatially variant prscription of dos radiation according to hypoxic tumor distribution assssd by hypoxia markrs and biological imaging: a phass I II study in non small cll lung cancr. CROB Nappi Antonio Biomdica Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Molcular undrstanding of E3 ligass involvd in signaling and cancr I.E.O. Pasqualato Sbastiano Biomdica Biological Chmistry and Macromolcular Biophysics Macromolcular Structur and Function C MSFC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 300 di 356

301 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rol of xosoms on immun rspons inflammatory/rgulatory balanc during chronic HCV and HBV infctions SPALLANZANI Agrati Chiara Biomdica Immunology Immunity and Host Dfns IHD Altrations of gut barrir and lipid mtabolism in subjcts with livr statosis: novl insights into molcular targts and intrvntions using prbiotics DE BELLIS Notarnicola Maria Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Intstinal microbiota and chronic inflammatory disas in childrn Toscana Liontti Paolo Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Assssmnt of th thraputic valu of targting cancr stm clls in Numb dficint brast cancr. I.E.O. Tosoni Danila Biomdica Oncology 1 Basic Tumor Cll Biology TCB Evaluation of human xposur to Ads mosquitos: intgration of molcular and immunological approachs for th dvlopmnt of novl tools to assss vctor control stratgis and stimat arboviral disas risk. Istituto Suprior di Sanita' DI LUCA MARCO Biomdica Infctious Disass and Microbiology Vctor Biology VB Variclla zostr infctions in patints on immunosupprssant thrapy: prognostic rol and valu of vaccin prvntion Puglia Grminario Cinzia Annata Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Th "Eldrly Projct" aimd at th prospctiv multidimnsional assssmnt of ldrly patints with Diffus Larg B Cll Lymphoma ARCISPEDALE MERLI FRANCESCO Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Thyroid dysfunction and chmical compound xposur in th tiology of Attntion Dficit/Hypractivity Disordr (ADHD) Istituto Suprior di Sanita' Pani Pitro Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD A NUTRITIONAL APPROACH TO CANCER: A PILOT STUDY IN TWO AREAS OF CAMPANIA CHARACTERIZED BY DIFFERENT ENVIRONMENTAL RISK Istituto Suprior di Sanita' Strafac Elisabtta Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 301 di 356

302 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Vitamin D and Microbiota in colorctal cancr I.E.O. Gandini Sara Clinicoassistnzial Oncology 2 Chmo/Ditary Prvntion CDP A modl to assss th ffct of tissu ozonisation as a nw stratgy to trat ndomtriosis Friuli Vnzia Giulia Mariuzzi Laura Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER Pathophysiology of fatigu in Parkinson's disas and ffct of arobic rhabilitation SAN RAFFAELE PISANA STOCCHI FABRIZIO Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Failur of traditional risk factors in prdicting subclinical athrosclrosis. Sarch for novl imaging basd, biochmical and molcular markrs in a clinically halthy population. SAN MATTEO DE SERVI STEFANO Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Study on micrornas as arly prdictors of contrastinducd nphropathy in patints with acut myocardial infarction tratd with prcutanous coronary intrvntion. Emilia Romagna Ansani Lucia Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Anglman Syndrom: a clinical nurophysiological, functional imaging and biochmical invstigation to uncovr nw thraputic stratgis MEDEA Bonanni Paolo Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD IS CHOLESTERYL ESTER STORAGE DISEASE AN UNDER RECOGNIZED CAUSE OF ATHEROSCLEROSIS AND LIVER DYSFUNCTION? Pimont Guardamagna Ornlla Biomdica Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Msnchimal stromal clls for congnital and acquird skin lsions. rsarch in pdiatric surgry SAN MATTEO Plizzo Gloria Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 302 di 356

303 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv RAVER2 mdiatd RNA procssing disrgulation in Autosomal Dominant Lukodystrophy Istituto Scinz Nurologich Capllari Sabina Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Circulating ndothlial clls (CEC) and microrna as novl biomarkrs prdicting th rspons to antiangiogntic thrapy in pithlial ovarian cancr C.R.O. AVIANO ROSSI FRANCESCA Biomdica Oncology 2 MARIA Cancr Biomarkrs Targt idntification and rlvanc assssmnt of rgistrd drugs with mylin rpair potntial Istituto Suprior di Sanita' Agrsti Cristina Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Dsign of rational and innovativ immunogns basd on HIV 1 clad C Env protins spcifically mutatd in slctd consrvd glycans for broadly ffctiv vaccin purpos Istituto Suprior di Sanita' Cnci Alssandra Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP ROLE OF THE DNAM 1/PVR PATHWAY IN THE PATHOGENESIS OF HIV 1 INFECTION OSPEDALE BAMBINO GESU' Doria Marghrita Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP A novl intgratd approach to th diagnosis and prognosis of Disordrs of Consciousnss Emilia Romagna PIPERNO ROBERTO Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Prsistnt toxic pollutants (PTS) in Mditrranan safood: Analysis of tim trnds and ditary xposur risk assssmnt [MdFoodRisk] Istituto Suprior di Sanita' Miniro Robrto Biomdica Vtrinary Food Safty FOSA Mtastatic potntial of CD44v6 + circulating tumor clls in gastrointstinal malignancis CROB Aita Michl Clinicoassistnzial Oncology 2 Cancr Biomarkrs A ddicatd informatics tool to assist both mdical dcision making and costs burdn valuation in surgry intrvntion for thyroid patints REGINA ELENA APPETECCHI A MARIALUISA Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 303 di 356

304 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Early athrosclrosis in patints with statosis and with chronic hpatitis C: rol of viscral adiposity, procoagulant imbalanc and ndothlial dysfunction in vascular damag MAGGIORE Fracanzani Anna Ludovica Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Ex vivo stratification of sarcoma patints who could bnfit of targtd adjuvant thrapy PASCALE Fazioli Flavio Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM Mitochondrial functional Indx through approach focusd on Oxidativ mtabolism SAN GALLICANO Dll'Anna Maria Lucia Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Daily monitoring of pdiatric asthmatic outpatints: pollution and halth rlationship. Studis of th adoption and dissmination of halth risk bhavior prvntiv intrvntions and srvics or adhrnc to tratmnt and/or complmntary tratmnts OSPEDALE BAMBINO GESU' Cutrra Rnato Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM stm clls on structural fat grafting Emilia Romagna GALIE' MANLIO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Prdictiv biomarkrs of rspons to PARP 1 inhibition as thraputic stratgy to improv DNA damaging agnts fficacy in bon and soft tissu sarcomas Istituto Oncologico Candiolo Grignani Giovanni Biomdica Oncology 2 Cancr Biomarkrs EVALUATION OF THE THERAPEUTIC ACTIVITY OF UNIVERSAL, ANTI BETA GLUCAN ANTIBODIESAGAINST MAJOR HUMAN FUNGAL PATHOGENS Istituto Suprior di Sanita' chiani paola Biomdica Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F13 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 304 di 356

305 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv From gns to connctom: intractions btwn gntic, nvironmntal, cognitiv and brain factors in patints with prclinical and clinical Alzhimr s Disas. SANTA LUCIA Srra Laura Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration BRAIN CONNECTIVITY IN EARLY POST SURGICAL PRIMARY BRAIN TUMOR PATIENTS: RELEVANCE FOR PREDICTING INTENSIVE EARLY POST SURGICAL REHABILITATION OUTCOME MAUGERI BASSO Gianpaolo Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration MiRNA xprssion profil in Amyotrophic Latral Sclrosis and intraction with biomarkrs of clinical faturs Puglia Simon Isablla Laura Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration A systmatic us of computr support finalizd to prvnt th rnal toxicity of drugs intraction and dosag. Emilia Romagna Bianchi Stfano Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Blood Managmnt Program in cancr surgry ARCISPEDALE Bonini Alssandro Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Idntifying if rcommndd glucos targts ar associatd with an incrasd risk on ngativ outcoms in ldrly frail patints with Typ 2 Diabts I.N.R.C.A. Abbatcola Angla Mari Clinicoassistnzial Population Scincs and Epidmiology Kidny, Nutrition, Obsity and Diabts KNOD mirna signatur of arly nuroglial involvmnt in th rtina of diabtic patints. BIETTI Varano Monica Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Th Hrditary Diffus Gastric Cancr syndrom: from suscptibility gns to clinical managmnt I.E.O. BONANNI BERNARDO Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Th contribution of gntic and mtabolic factors to drug rsistanc in pdiatric nphrotic syndrom. MAGGIORE Turolo Stfano Clinicoassistnzial Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 305 di 356

306 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv MICROTISSUE PRODUCTION FROM HUMAN GLIOBLASTOMA STEM CELLS: A NEW PRECLINICAL MODEL TO INVESTIGATE NOVEL TARGETS FOR PRECISION TREATMENTS Istituto Scintifico Romagnolo Tsi Anna Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Idntification of imaging biomarkrs for th biological charactrisation of high grad crbral tumours. HUMANITAS CHITI ARTURO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI AN INTEGRATED WORKFLOW TO DISCOVER COMPOUNDS ABLE TO MODULATE THE BONE MORPHOGENETIC PROTEIN SIGNALING GASLINI Bocciardi Rnata Biomdica Cll Biology Cllular Signaling and Rgulatory Systms CSRS Inducd pluripotnt stm clls (ips) as a nw modl for cardiac and skltal muscl pathognsis in myotonic dystrophy typ 1 (DM1). DON GNOCCHI Santoro Massimo Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Comparison among diffrnt chronic disas modls in Lombardia Rgion and analysis and dsign of innovativ stratgis to improv quality of car and optimis rsourcs' utilisation. Intgration of th diffrnt modls, with halth and tlmdicin su Lombardia VAGHI ADRIANO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD NK, hrpsvirus infction and HLA G molculs as prognostic markrs for primary unxplaind infrtility. Emilia Romagna Marci Robrto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular, Molcular and Intgrativ Rproduction CMIR Us of agricultural by products as fd supplmnt for prvntion of Campylobactriosis IZSME Garofalo Francsca Biomdica Vtrinary Food Safty FOSA ASSESSING A NOVEL RNA BASED THERAPEUTIC APPROACH FOR DOMINANT NEGATIVE MUTATIONS IN COLLAGEN TYPE VI RELATED MUSCULAR DYSTROPHIES: TARGETING SINGLE NUCLEOTIDE POLYMORPHISMS TO PROMOTE OUT OF FRAME EXON SKIPPING AND ALLELE SPECIFIC GENE SILENCING. Emilia Romagna Gualandi Francsca Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 306 di 356

307 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Omga 3 basd nutracuticals as modulators of ndocannabinoid signaling: a potntial stratgy for mchanistic undrstanding and managmnt of Alzhimr's disas SANTA LUCIA Maccarron Mauro Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration RECONSTRUCTION OF HUMAN URETHRA WITH A REGENERATIVE MEDICINE PROCOL IN URETHRAL STRICTURE REPAIR Umbria Costantini Elisabtta Biomdica Digstiv, Kidny and Urological Systms Rnal and Urological Scincs Small Businss Activitis SERU REDOX REGULATION OF MUTYH DNA GLYCOSYLASE ACTIVITY VIA ITS IRON SULFUR CLUSTER AND ROLE IN INFLAMMATION Istituto Suprior di Sanita' MAZZEI FILOMENA Biomdica Oncology 1 Basic Cancr Etiology CE Mothr child immunogntic intractions in prgnancy and risk of Autism Spctrum Disordrs DON GNOCCHI Gurini Franca Rosa Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Paratubrculosis in shp and goats in southrn Italy, and risk rlatd to th consumption of dairy products contaminatd by Mycobactrium avium subsp. paratubrculosis Scurity in animal nutrition: Th us of formaldhyd and zinc as additivs for animal fd production IZSLER Arrigoni Norma Biomdica Vtrinary Food Safty FOSA IZSSI MACALUSO ANDREA Biomdica Vtrinary Food Safty FOSA Campania Rgistry study on Acut dcompnsatd Hart Failur (CRAHF): significanc, implmntation and rduction of clinical outcoms Campania BONADUCE DOMENICO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Right Intrnal Thoracic Artry as Blood Supply for Saphnous Vin Bypass Graft Friuli Vnzia Giulia Bnussi Brnardo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS EMrging MEditrranan BIOtoxins in fish and shllfish products: mthods for th idntification of algal toxins and study on th mchanism of action, trophic transfr and potntial risk for th human halth (EMMEBIO) IZSUM Orltti Robrta Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 307 di 356

308 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Patho molcular mchanisms' dissction of bicuspid aortic valv: clinical and thraputic implications. Toscana Pp Guglilmina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Intrplay btwn Myloid Drivd Supprssor Clls and Hmatopoitic Prognitor Clls: rol in th rgulation of immun rspons and immun rconstitution procss during HIV infction. SPALLANZANI Sacchi Alssandra Biomdica AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Anti inflammatory ffcts of vagal activation in patints with ST lvation myocardial infarction tratd with primary prcutanus coronary intrvntion SAN MATTEO DE FERRARI GAETANO Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Rol of anti LRP4 antibodis in motor nuron and nuromuscular junction altration in ALS CARLO BESTA Mantgazza Rnato Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Chronothrapy in Hart Failur:Convntional vrsus Tmporizd thrapy in Hart Failur (CONVERT HF) Emilia Romagna MANFREDINI ROBERTO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Establishmnt of a clinical and biological (biobank) rgistry for chronic migrain: from knowldg of th phnomnon to implications for public halth Emilia Romagna Manzoni Gian Camillo Clinicoassistnzial Population Scincs and Epidmiology Bhavioral Gntics and Epidmiology BGES Sarch for pathognic mchanisms of haploinsufficincy of LETM1 and WHSC1 in Wolf Hirschhorn syndrom and thraputic trial with Vitamin C. Lazio Zollino Marclla Biomdica Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD Idntification and validation of a Panl of suitabl biomarkrs usful for radiation Risk Assssmnt associatd with low and protractd DOSs ncountrd in nuclar mdicin (PARADOS) Istituto Suprior di Sanita' Tabocchini Maria Antonlla Biomdica Oncology 2 Radiation Thraputics and Biology RTB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 308 di 356

309 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Assssing Amyloid PET Pattrns in MCI patints for an improvd prdiction of Convrsion to AD Liguria ciarmillo andra Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Toward idntification of biomarkrs in patints with irritabl bowl syndrom (IBS) Emilia Romagna Barbara Giovanni Clinicoassistnzial Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB An pigntic stratgy to incras chmosnsitivity in cancr: Malignant Msothlioma as a modl SAN RAFFAELE MILANO Agrsti Alssandra Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Charactrization of ipsc drivd nurons from individuals with Autism Spctrum Disordrs: an in vitro modl for prclinical drug scrning Toscana Canitano Robrto Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD ROLE OF ADIPOSE TISSUE IN THE PANCREATIC CANCER MICROENVIRONMENT Vnto ZAMBONI MAURO Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Early diffrntiation of rspondrs from non rspondrs in patints with Crohn's disas through th quantitativ analysis of tim intnsity curvs obtaind aftr microbubbl contrast agnt injction Friuli Vnzia Giulia Emilio Quaia Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Authnticity of oliv oil: Paramtrs and innovativ mthods to prsrv th originality of Italian products IZSSI frrantlli vincnzo Biomdica Vtrinary Food Safty FOSA Sustainability and quality of car: th rol of ffctiv multi dimnsional and multi lvl PRfOrmanc managmnt systm (PMS) in halthcare organizations (PROCARE) Emilia Romagna Nicoli Maria Augusta Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Th dvlopmnt of a nw systm to optimiz th tratmnt of Cystic Fibrosis in adults: intllignt polymric nanovctors and microcapsuls to ovrcom mucus barrir. A translational rsarch to satisfy a still unmt mdical nd. Pimont Albra Carlo Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 309 di 356

310 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th transcription factor Prp1 as a novl molcular link for typ 2 diabts and adipocyt rlatd pathologis. Campania Orint Francsco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Cllular Aspcts of Diabts and Obsity CADO Thr dimnsional musculoskltal ultrasound in juvnil idiopathic arthritis (JIA): dvlopmnt of a nw, fasibl tool for th assssmnt of disas activity and to support clinical dcisions and thraputic stratgy OSPEDALE BAMBINO GESU' Magni Manzoni Silvia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Inappropriat mdical prscriptions: a ntwork for patints' safty. From pidmiology to mdical lgal aspcts: valuation of an ducativ/informativ stratgy for prvntion. Molis Campobasso Carlo Pitro Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD AGEING RELATED HEART AND BONE FUNCTIONAL IMPAIRMENTS: A CLINICAL AND EXPERIMENTAL STUDY ON POTENTIALLY SHARED PATHOGENETIC PATTERNS SAN RAFFAELE MILANO fragasso gabril Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Intgratd multidisciplinary approach and not convntional ndoscopic/surgical basd stratgis in padiatric morbid obsity: clinical trials and idntification of novl potntial non invasiv biomarkrs for pr and post oprativ monitoring OSPEDALE BAMBINO GESU' DE PEPPO FRANCESCO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Th prognostic valu of collatral flow in acut ischmic strok scondary to occlusion of intracranial artris tratd by ndovascular thrapy. SANTA LUCIA Stanzion Paolo Clinicoassistnzial Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Tlhalth srvics for hom basd managmnt of patints with cardiovascular disas: multidimnsional assssmnt of Rmot Monitoring in Disas Managmnt Programs. Emilia Romagna D Palma Rossana Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Biological scaffold and clls for soft tissu rgnration aftr dbulking surgry in oncologic fmal patints Emilia Romagna D Iaco Pirandra Biomdica Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 310 di 356

311 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Thory of mind aftr tmporal lob pilpsy surgry: A prospctiv study CARLO BESTA Giovagnoli Anna Rita Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Exploiting a cancr volatil signatur from xhald brath for brast cancr arly diagnosis ISTITUTO TUMORI MILANO Orlandi Rosaria Clinicoassistnzial Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Dvlopmnt of a nw diagnostic tool, in th fild of in vivo clinical imaging, basd on a hybrid tchnology consisting of a combination btwn optical contrast (lasr) and ultrasound imaging. Campania Gatta Gianluca Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT EARLY STUDY. MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEENEARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. Pimont Ccchi Enrico Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Novl pharmacological stratgis for Wilson's disas cur: corrction of mutant ATP7B protins through supprssion of intracllular dgradation procsss. From thrapy to pathognsis of damag inducd by coppr accumulation. Campania IORIO RAFFAELE Biomdica Cll Biology Mmbran Biology and Protin Procssing MBPP Intnsity modulatd clinical stting Hospitals: impact on Halth Population Outcoms Agnzia pr i Srvizi Sanitari Rgionali Davoli Marina Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Idntification of biological and imaging vnts that prdict th progrssion of Takayasu artritis vascular lsions SAN RAFFAELE MILANO Sabbadini Maria Grazia Clinicoassistnzial Immunology Hyprsnsitivity, Autoimmun, and Immun Mtagnomics and mdicin: analysis and modling of gut and gastric microbiota in Barrtt's sophagus and sophagitis. Toscana Bchi Paolo Clinicoassistnzial Oncology 2 Cancr Biomarkrs Colon Cancr: idntification of high risk individuals through gntic scrning SAN MATTEO Dionigi Paolo Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 311 di 356

312 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Idntification of novl gns involvd in inhritd nphropathis causing nd stag rnal disas at a young ag through whol xom squncing and copy numbr analysis. Pimont Quaglia Marco Clinicoassistnzial Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Scond Primary Malignancis in Thyroid Cancr Survivors: Epidmiological Impact, Pathogntic Factors and Implications ARCISPEDALE frasoldati andra Biomdica Population Scincs and Epidmiology Epidmiology of Cancr EPIC AN INTEGRATIVE APPROACH TO EPISODIC VERTIGO SAN RAFFAELE MILANO Tggi Robrto Clinicoassistnzial Molcular, Cllular, and Dvlopmntal Nuroscinc Nurotransportrs, Rcptors, Channls and Calcium Signaling NTRC Ochratoxin A in gratd chs: occurrnc, study of surfac migration, risk managmnt and rgulatory activity proposal IZSLER BIANCARDI ALBERTO Biomdica Vtrinary Food Safty FOSA Optimization of adoptiv immunothrapy protocols for EBV drivn tumors xprssing a rstrictd pattrn of subdominant viral antigns C.R.O. AVIANO Dolctti Riccardo Biomdica Oncology 2 Cancr Immunopathology and Immunothrapy CII Rsarch, dsign, analysis, dvlopmnt, tst and tuning of a wb basd informatic systm vn usd on Tablt Android to support and coordinat all activitis of inspction, monitoring and sampling aimd at improvmnt of data xchang with Local Halth A Emilia Romagna ALDROVANDI AURELIO Biomdica Vtrinary Animal Halth ANHE ObSity And rnal Function in pediatric ag: an pidmiological study in th CAlabrian rgion invstigating Rnal dysfunction in ovrwight/obs adolscnts. Th SAFEGUARDCKD projct. Calabria Postorino Maurizio Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD Markrs of disas progrssion in mtabolic and cardiovascular disass causd bymutations in lamins. RIZZOLI Lattanzi Giovanna Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 312 di 356

313 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Diagnostic and thraputic cours of oncologic patints with focus on biological drugs Sardgna Minrba Luigi Clinicoassistnzial Oncology 2 Oncology CONC Vitamin D Supplmntation on Assistd Rproduction Tchnology (ART) outcoms: a randomizd clinical controlld trial and an invstigation of th involvd biological mchanisms MAGGIORE Somigliana Edgardo Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ and Endocrinology and Rproduction ICER MECHANISMS CONTROLLING COGNITIVE IMPAIRMENT IN MORBIDLY OBESE PATIENTS Lazio Raffalli Marco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Intractions btwn Epstin Barr virus and human cytomgalovirus infctions and systmic lupus rythmatosus: an intgratd virological, immunological and clinical analysis SAN MATTEO CAVAGNA LORENZO Biomdica Immunology Immunity and Host Dfns IHD Robot assistd rhabilitation of th uppr limb: a nw prspctiv for snsory and motor training MAUGERI Colombo Robrto Biomdica Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Novl approachs for scrning of humoral primary immunodficincis in adult patints Toscana Matucci Andra Clinicoassistnzial Immunology Immunity and Host Dfns IHD Th prognostic valu of noangiognsis in Colo Rctal Cancr (CRC): a combination of stablishd and innovativ prob basd Confocal Lasr Endomicroscopy (pcle) approachs C.R.O. AVIANO Cannizzaro Rnato Clinicoassistnzial Oncology 2 Cancr Biomarkrs Amniotic stm clls to improv congnital kidny damag: a ftal lamb modl SAN MATTEO Avolio Luigi Biomdica Digstiv, Kidny and Urological Systms Urologic and Kidny Dvlopmnt and Gnitourinary Disass UKGD Th Activity Basd Managmnt applid to a comprhnsiv cancr cntr. IRCCS AOU San Martino IST (Gnova) COPELLO FRANCESCO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 313 di 356

314 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Butyrat as innovativ thraputic stratgy against pdiatric obsity complications Campania Franzs Adriana Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Diabts, Mtabolism, Nutrition and Obsity Small Businss SEP (EMNR E10 B) Effcts of multimodal training on cognition, biomarkrs, rs FMRI and brain structural intgrity in MCI patints Abruzzo Snsi Stfano Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Study of th molcular mchanisms undrlying oncogndpndnt DNA rplication strss I.E.O. Dllino Gatano Ivan Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Thrapis for inborn rrors of mtabolism Campania Bruntti Pirri Nicola Biomdica Gns, Gnoms and Gntics Gn Thrapy and Inborn Errors GTIE Spcial Emphasis Panl Olfaction as an indx of convrsion from MCI to AD: a longitudinal functional connctivity study Emilia Romagna Nichlli Paolo Frigio Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Somatosnsory and Chmosnsory Systms SCS Validation of a nw Low Cost Point of Car systm for bilirubin dtrmination in nwborns Impact on hyprbilirubinmia prvntion and cost rduction for th National Halth Systm (SSN) BURLO GAROFALO Travan Laura Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Idntification of small molculs activ against HIV 1 mmory T cll rsrvoirs through th inhibition of thir homostatic prolifration Istituto Suprior di Sanita' Battistini Angla Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Association btwn long trm xposur to air pollution and nurological and mtabolic impairmnt in adults of two larg Italian longitudinal studis Pimont Galassi Claudia Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Intrautrin prvntion of prinatal and arly infancy obsity Emilia Romagna facchintti fabio Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 314 di 356

315 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dsign of innovativ composit biomatrials using transglutaminas mdiatd cross links for bon tissu rgnration and possibl applications for thrapy. Sicilia Intil Riccardo Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI GUT MICROBIOTA AND INFLAMMASOME IN THE PATHOGENESIS OF ALZHEIMER S DISEASE DON GNOCCHI Clrici Mario Salvator Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Isolation, immunophnotypic molcular biological charactrization and banking of human msnchymal stm clls; idntification of novl, sustainabl mthods for x vivo xpansion and uni linag diffrntiation for clinical applications Calabria Gasparini Giorgio Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE Prclinical assssmnt of th radiosnsitizing activity of NEDD8 pathway inhibition in rctal cancr Istituto Oncologico Candiolo Gabril Pitro Biomdica Oncology 2 Radiation Thraputics and Biology RTB Idntification of nuronal substrats of Phlan McDrmid syndrom to idntify thrapis in prclinical modls: corrlation btwn clinical outcom and molcular phnotyps of human nurons drivd from patint s hips clls CARLO BESTA D'Arrigo Stfano Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Standardization of innovativ mthods of molcular diagnostics for th dvlopmnt of a prognostic and thraputic prsonalizd approach to patints affctd with colo rctal cancr Lazio Ruggri Enzo Maria Clinicoassistnzial Oncology 2 Cancr Biomarkrs Immun and DNA rpair rlatd gn signaturs for th prdiction of risk of tumour rcurrncs and brain mtastasis in HER2 positiv brast cancr patints HUMANITAS Santarpia Libro Biomdica Oncology 2 Cancr Biomarkrs Alzhimr's disas as a systmic disordr: molcular targts and clinical corrlats Sicilia BERNARDINI RENATO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 315 di 356

316 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Influnc of phosphat mtabolism in th clinical phnotyp and pathognsis of bon, minral and cardiomtabolic disordrs CASA SOLLIEVO SOFFERENZA Battista Claudia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Novl biomarkrs and thrapy targts for Anaplastic Thyroid Carcinoma thrapy: th BAG3 BRAF pathway PASCALE Chiapptta Gnnaro Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Th apicoplast translational apparatus as a targt for th dvlopmnt and charactrization of nw antimalarial agnts. Istituto Suprior di Sanita' Mngon Michla Biomdica Infctious Disass and Microbiology Drug Discovry and Mchanisms of Antimicrobial Rsistanc DDR Mdium and long trm comparativ ffctivnss and costs analysis of TAVI vs AVR in patints with svr symptomatic aortic stnosis at mdium low risk Sicilia Tamburino Corrado Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Comparison of prsonality and priphral biological markrs in young Italians with and without intrnt addiction Toscana Dll'Osso Liliana Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Rport AGE Projct: clinical and biological prdictors of physical function dclin in oldr patints with chronic cardiovascular disass I.N.R.C.A. Bustacchini Silvia Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Bactricidal/prmability incrasing fold containingfamily B mmbr 4 as a nw thraputic targt to fight cardiovascular disass NEUROMED Vcchion Carmin Biomdica Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Rducd aspirin action in diabtic patints at high risk of cardiovascular vnts: cllular and molcular studis on mgakaryocyt prognitor clls and platlts. Istituto Suprior di Sanita' Gurriro Raffalla Biomdica Vascular and Hmatology Hmostasis and Thrombosis HT Bta cll gns and diabts: from MODY to atypical typ 1 or typ 2 diabts Emilia Romagna Mantovani Vilma Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 316 di 356

317 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Unmasking organ confind prostat tumors with highlyinvasiv profil SAN RAFFAELE MILANO Cavarrtta Ilaria Biomdica Oncology 2 Cancr Biomarkrs DISSECTION OF FATTY ACID SYNTHASE ROLE AS A DETERMINANT OF DRUG RESPONSE AND RESISTANCE IN DIFFUSE MALIGNANT PERITONEAL MESOTHELIOMA THROUGH THE INTEGRATION OF GENE AND microrna PROFILES ISTITUTO TUMORI MILANO Prgo Paola Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT DIMCAT: Don Gnocchi ICF Info Multicntr Application Trial DON GNOCCHI Ngrini Stfano Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Intgration of information sourcs (administrativ and txtual databass plus clinical rgistris) into modls for quality valuation, outcom analysis, tchnology and conomic assssmnt, and support for clinical dcision and halthcar planning focus Lombardia Maria Frigrio Clinicoassistnzial Risk, Prvntion and Halth Bhavior Bhavioral Mdicin: Intrvntions and Outcoms BMIO FTD gnotyp phnotyp corrlation in two population clustrs with common gntic background living in diffrnt continnts. Calabria Colao Rosanna Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Discovry of distinct plasma micro RNA xprssion pattrn in ndomtriosis and ndomtriosis associatd ovarian cancr Sicilia Corsllo Salvator Biomdica Oncology 2 Cancr Biomarkrs Common pathognic stps in nuromuscular disass: disscting th rol of mir 21 and mir 206 in SMA and ALS mic and human patints. CARLO BESTA Locatlli Dnis Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Cllular and Molcular Biology of Nurodgnration CMND Comparativ ffctivnss of a hom car tlmdicin intrvntion to monitor th rspiratory prformanc of patints with ALS. Friuli Vnzia Giulia Pisa Fdrica Edith Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 317 di 356

318 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv GENE ENVIRONMENT INTERACTIONS IN SARCOIDOSIS. ROLE OF ENVIRONMENTAL INFLUENCES ON SARCOIDOSIS SUSCEPTIBILITY GENES Emilia Romagna Brtorlli Giusppina Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR Lipid biomarkrs of nuroaxonal damag for disability progrssion prdiction in Multipl Sclrosis Istituto Suprior di Sanita' Minghtti Luisa Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Rduction into practic of a clinical grad stm cll markr basd signatur for th prognostic prdiction of brast cancr. I.E.O. Pc Salvator Biomdica Oncology 2 Cancr Biomarkrs Comparing attndanc rat and advancd noplasia yild of colonoscopy and yarly FIT for post polypctomy survillanc of patints with intrmdiat and high risk adnomas Pimont Snor Carlo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Flavors and mtabolic altrations rlatd to impropr fding bhavior in mammals Istituto Suprior di Sanita' Guidotti Marco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F Rol of FDG positron mission tomography (PET) and immunological markrs in prdicting outcom in largvssl vasculitids (giant cll artritis and Takayasu artritis) ARCISPEDALE Pipiton Nicolò Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS Cll thrapy clinical trial with Msnchymal Stm Clls (MSCs) as vhicl to dlivr paclitaxl for th tratmnt of lung mtastatic tumours in dogs IZSSI Gurcio Annalisa Biomdica Oncology 2 Dvlopmntal Thraputics DT Exploring th rol of gntics in juvnil strok: an xom pilot study. Toscana Nncini Patrizia Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 318 di 356

319 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Thr Month Wkly Rifapntin/Isoniazid Vrsus 6 Month Slf administrd Daily Isoniazid with or without SMS Rmindrs for th Tratmnt of Latnt Tubrculosis Infction among Immigrants in Italy: a Randomizd Trial Lombardia Mattlli Albrto Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Nxt gnration squncing and nw disas modls to idntify th molcular mchanisms and thraputic targts of astrocyt dysfunction in autism pilpsy phnotyp Istituto Suprior di Sanita' Ambrosini Elna Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Targtting th intrlukin 6 rcptor as a novl thraputic approach in Duchnn muscular dystrophy to modulat muscl inflammation and rgnration OSPEDALE BAMBINO GESU' d bndtti fabrizio Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Fluorscnc guidd surgical rsction of high grad gliomas with sodium fluorscin: a phas III clinical trial CARLO BESTA Broggi Morgan Aldo Clinicoassistnzial Oncology 2 Oncology CONC Epidmiology and cost valuation of strok in Italy Toscana Lamassa Maria Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD GENDER RELATED INSIGHT INTO CARDIOVASCULAR RISK: A SYSTEM MEDICINE APPROACH Toscana Abbat Rosanna Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Rigorous maintnanc of normoxia vrsus hyproxia in critically ill patints admittd in intnsiv car unit. A randomizd multicntr study. Emilia Romagna Rinaldi Laura Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Add on short trm thrapy with pgylatd intrfron alfa in patints with HBAb positiv chronic hpatitis B who ar long trm rspondrs to nuclos(t)id tratmnt: dos it allow complt withdrawal of antiviral thrapy and dos it rduc th risk of liv Lazio Anglico Mario Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 319 di 356

320 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv DATA MINING IN CLINICAL TRIALS: INVESTIGATING SYMPTOM NETWORKS TO IMPROVE THERAPEUTIC STRATEGIES FOR MAJOR DEPRESSION Istituto Suprior di Sanita' Giuliani Alssandro Biomdica Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA Viral prsistnc, chronic immun activation, and drug pntration in th Cntral Nrvous Systm of HIVinfctd subjcts: prdictors of viral compartmntalization in crbrospinal fluid and clinical outcoms (CENES Study). SPALLANZANI Prno Carlo Fdrico Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Immunology and Pathognsis AIP Rnal Dnrvation in Patints with Advancd ChronicHart Failur (NYHA f. C. III), Nding High Loop Diurtic Dos. MULTIMEDICA Gronda Edoardo Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Distinct dvlopmntal programs of cord blood and bon marrow hamatopoitic stm clls rconstitut diffrnt B cll compartmnts in transplantd patints lading to transplant spcific immun impairmnt. Cllular and molcular charactrization of transi OSPEDALE BAMBINO GESU' Carstti Rita Biomdica Immunology Immunity and Host Dfns IHD Dvlopmnt of innovativ compoundsfor th tratmnt of rnal cll carcinoma and Von Hippl Lindau Syndrom Abruzzo Tinari Nicola Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT NEURO SCD: Suddn Cardiac Dath (SCD) and Nuropsychiatric drugs consumption. Lazio Pascali Vincnzo Lornzo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Elctrical Signaling, Ion Transport, and Arrhythmias ESTA Comparisons of Hpatic Transint Elastography and Acoustic Radiation Forc Impuls Masurmnts of Livr and Spln, Prformd Bfor Livr Biopsy. Sicilia Catalano Danila Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Organic vs convntional: sprading assssmnt of crtain dairy hrds disass IZSSA Orrù Andra Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 320 di 356

321 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Validation of PTEN as diagnostic, prognostic and thraputic prdictiv bio markr in colorctal cancr and idntification of nw thraputic targts. Campania D Rosa Marina Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Epigntics in dystrophic pidrmolysis bullosa: towards novl thrapis to countract drmal fibrosis and carcinoma dvlopmnt ISTITUTO DERMOPATICO DELL'IMMACOLATA Castiglia Danil Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Rol of th motor cortx in th pathognsis of th Amyotrophic Latral Sclrosis disas SANTA LUCIA Zona Cristina Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN Idntification of halth intrvntions to b offrd to populations living in aras affctd by nvironmntal pollution: dvlopmnt and pilot application of an vidnc basd approach. Pimont Miglior Enrica Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Impact of intrmittnt and continuous hypoxia on factors dtrmining th dvlopmnt of athrosclrosis and cardiovascular risk in hyprtnsiv subjcts with obsity and mtabolic disordrs. AUXOLOGICO Bilo Grzgorz Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Functional link btwn myloid supprssor clls and inhibition of protctiv T cll rsponss in mlanoma patints. GALEAZZI Rali Eva Biomdica Immunology Transplantation, Tolranc and Tumor Immunology TTT Acoustic Spctroscopy of Lung Toscana Dmi Marcllo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT Strngth and rsistanc Exrcis Thrapy (ET) to control Aromatas Inhibitors (AIs) muscloskltal advrs ffcts and improv Quality of Lif (QoL) in ldrly brast cancr survival womn PASCALE Pinto Monica Clinicoassistnzial Oncology 2 Oncology CONC FOODBORNE BOTULISM IN ITALY: IMPROVEMENT OF MEASURES FOR DIAGNOSIS, PREVENTION AND CONTROL OF THE DISEASE Istituto Suprior di Sanita' D Mdici Dario Biomdica Vtrinary Food Safty FOSA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 321 di 356

322 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Invstigating hparanas in synovial sarcoma as a targt of innovativ thrapis ISTITUTO TUMORI MILANO Lanzi Cinzia Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT A thr yar rsarch projct conductd in a pdiatric hospital cardiology unit dsignd to invstigat whthr activly liciting prfrncs and wishs in young patints with hart failur and thir parnts in vidnc basd diagnostic and thraputic o OSPEDALE BAMBINO GESU' Rosati Paola Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD No mor mrgncis in DNA spcis idntification: dvlopmnt and harmonization of molcular and nxt gnration mthods to dtrmin and quantify origin spcis in food and to discriminat frauds from unintntional contamination. IZSPLV Pltto Simon Biomdica Vtrinary Food Safty FOSA Oxidativ strss and arly prgnancy complications Lazio Piccion Emilio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN EFFECTS ON THE INHALATION OF MOUNT ETNA'S VOLCANIC ASHES AND HEALTH RISK: STUDY IN VITRO OF THE POTENTIAL ALTERATIONS IN THE INNATE IMMUNOLOGIC RESPONSE AND IN THE ALVEOLAR ENVIRONMENT Sicilia CRIMI NUNZIO Biomdica Cardiovascular and Rspiratory Scincs Lung Cllular, Molcular, And Immunobiology LCMI Effcts of continuous and intrmittnt long trm ltrozol administration on cognitiv function in postmnopausal brast cancr patints I.E.O. Pravttoni Gabrilla Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Box of rain for Critical limb ischmia: a phas II singl arm trial. SAN MATTEO Argntri Anglo Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiovascular Diffrntiation and Dvlopmnt CDD GAIT ROBOTIC REHABILITATION IN CHILDREN WITH CONGENITAL OR ACQUIRED BRAIN INJURIES OSPEDALE BAMBINO GESU' Castlli Enrico Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F01 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 322 di 356

323 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv LIPID METABOLISM AND VASCULAR HEALTH IN MORBID OBESITY: IMPACT OF BARIATRIC SURGERY Umbria LUPATTELLI GRAZIANA Clinicoassistnzial Vascular and Hmatology Athrosclrosis and Inflammation of th Cardiovascular Systm AICS CoNan Cobalt Nanoparticls for Multimodal Molcular Imaging Emilia Romagna Marngo Mario Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT Molcular dissction of th cross talk btwn cll plasticity and autophagy in brast cancr C.R.O. AVIANO Santarosa Manula Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Impact of Digital Information and Libraris on Lvls of car, Intrvntions, and Outcoms: IDILLIO Study. Lazio Vcchi Simona Clinicoassistnzial Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Intgratd approach to optimiz th tratmnt with S(+) scitalopram in MDD patints. Provincia autonoma Bolzano Andras Conca Clinicoassistnzial Biobhavioral and Bhavioral Procsss Adult Psychopathology and Disordrs of Aging APDA A PHASE II STUDY OF AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE. Emilia Romagna Andron Pitro Clinicoassistnzial Digstiv, Kidny and Urological Systms Hpatobiliary Pathophysiology HBPP Functional and molcular charactrization of th pigntic ntwork that controls gn xprssion during nurognic muscl atrophy: nw potntial targts for thrapis against muscl wasting causd by nurognic disordrs and aging. SANTA LUCIA BERGHELLA LIBERA Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Muscular vibration asociatd with transcranial magntic stimulation may rliv spasticity in patints with multipl sclrosis NEUROLESI MILARDI DEMETRIO Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 323 di 356

324 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dit, PCDD/F, PCB, OCP, BPA, OP and NP xposur, intrautrin and arly postnatal growth, DNA mthylation and childhood obsity risk Vnto MAFFEIS CLAUDIO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD Non invasiv prnatal tsting: ftal anuploidis risk dtrmination, mutation analysis in prgnancis at risk for monognic disordrs and circulating cll fr DNA dosag as a markr of prgnancy outcom. Toscana Torriclli Francsca Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Us of nxt gnration squncing basd mtagnomic approach to improv th tiologic diagnosis of acut non bactrial mningoncfalitis SPALLANZANI Capobianchi Maria Rosaria Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Biomchanical charactrization of Carotid Plaqu by innovativ ultrasound in strok(biocap): Validation Against Magntic Rsonanc Imaging and Immunoistochmistry of Radiofrquncy Basd Mthods Intgrating 3D Imaging and Flow Vlocity Distribution, and Toscana Palombo Carlo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Targting mitochondrial calcium handling in cor myopathis: an intgrativ approach towards novl thraputic stratgis Vnto Pgoraro Elna Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Risk Communication for food born disas prvntion IZSME Baldi Lordana Biomdica Vtrinary Food Safty FOSA Panallrgns in Pdiatrics: volution of th molcular allrgnic profil in childrn with pollinosis Emilia Romagna Ricci Giampaolo Biomdica Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP Idntifying prclinical phnotypic and biological markrs of Alzhimr's Disas in halthy ldrly at risk subjcts SANTA LUCIA Caltagiron Carlo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 324 di 356

325 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A prospctiv randomizd study for outpatint managmnt of chronic hart failur: Lung Ultrasound and Noninvasiv Cntral Vnous Prssur Masurmnt as additional diagnostic tools to standard physical xamination SAN RAFFAELE MILANO Agricola Eustachio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Idntification of arly and prdictiv markrs of individual risk for had and nck cancr Toscana GALLO ORESTE Biomdica Oncology 1 Basic Cancr Etiology CE ROLE OF HLA AND NATURAL KILLER CELL RECEPTORS IN THE OUTCOME OF CYTOMEGALOVIRUS (CMV) INFECTION: GENETIC AND FUNCTIONAL ANALYSIS OF KILLER IMMUNOGLOBULIN LIKE RECEPTORS (KIR), HLA AND NKG2 RECEPTORS VARIANTS IN THE CONTROL OF CMV INFECTION Sicilia DI BONA DANILO Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Undrstanding th intraction btwn inflammatory factors profil in strok patints to dsign a tailord thraputic approach MONDINO Candloro Elisa Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Govrnanc for th smart managmnt of popl with cognitiv disordrs and dmntia Calabria Garri Pitro Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rol of th Transcriptional Rprssor REST/NRSF in Nuroinflammation HUMANITAS Pozzi David Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Molcular Nuropharmacology and Signaling MNPS Implmntation of innovativ procdurs for th tratmnt of cortical myoclonus, using non invasiv rptitiv Transcranial Magntic Stimulation: assssmnt of clinical fficacy with standardizd scals and monitoring of th changs on cortical xcitabili CARLO BESTA Canafoglia Laura Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroplasticity and Nurotransmittrs T Dual targting of histon lysin dmthylas 1 (KDM1a) and histon dactylass (HDACs) or rtinoids with bifunctional inhibitors as novl anticancr agnts I.E.O. Varasi Mario Biomdica Oncology 1 Basic Tumor Cll Biology TCB Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 325 di 356

326 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Tumor charactristics and snsitivity to diffrnt tratmnts in human pancratic adnocarcinoma : towards an individualizd thrapy of cancr Lombardia Moroni Mauro Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Futur scnario in HCV infction thrapis: idntification of viral dtrminants of tratmnt outcom succss Lombardia Michli Valria Clinicoassistnzial Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Comprhnsiv gntic analysis in Parkinson Disas. Campania Criscuolo Chiara Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD Frquncy, impact on th prgnancy, and long trm clinical outcoms on th mothr and th ftus of prgnancy associatd cancrs: a rcord linkag study. MARIO NEGRI Tavani Alssandra Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC SELF REACTIVE T CELLS IN SEVERE OSTEOPOROSIS Pimont D'AMELIO PATRIZIA Biomdica Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Nw onst diabts aftr transplantation (NODAT) and glucocorticoids thrapy: looking for clinical, biochmical and gntics dtrminants March ARNALDI GIORGIO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE A SYSTEMYC APPROACH TO ENSURE THE SAFETY OF SICILIAN FOOD PRODUCTS IZSSI MARINO ANNA MARIA Biomdica Vtrinary Food Safty FOSA FAUSTA EVALUATING THE COST EFFECTIVENESS OF AN ORGANIZATIONAL MODEL OF RISK ANALYSIS AND PROBLEM SOLVING FOR HEALTHCARE ASSOCIATED INFECTIONS Sicilia DELIA Santi Antonino Clinicoassistnzial Infctious Disass and Microbiology Infctious Disass and Microbiology Fllowship F Influnc of diabts mllitus on tubrculosis: is autophagy dysfunction th missing link? SPALLANZANI Fimia Gian Maria Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP CANCER IN IMMUNOCOMPROMIzED POPULATIONS: NEW SURVEILLANCE STRATEGIES FOR SOLID TUMOURS C.R.O. AVIANO Vacchr Emanula Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 326 di 356

327 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Hospital hom clinical pathways in nurorhabilitation: cost ffctiv valuation of advancd tchnologis supporting cas managmnt and rhabilitation car NEUROMED Bartolo Michlanglo Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Prsonalizd tratmnt of arly/locally advancd and mtastatic brast cancr patints by gnomic analysis Abruzzo Ficorlla Corrado Biomdica Oncology 2 Cancr Biomarkrs , gntics and pidmiological assssmnt of familial and sporadic frontotmporal dmntias in a population basd study with th validation of a clinicalbasd cohort. CASA SOLLIEVO SOFFERENZA Sripa David Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Outcom and socio conomic impact of th dfinitiv tratmnt for th cardiac dvic rlatd infctions Sicilia Calvagna Giuspp Mario Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Dlivring cognitiv stimulation through tlcommunication tchnology to prvnt dmntia S.CAMILLO Cagnin Annachiara Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Brain Disordrs and Rlatd Nuroscincs Fllowship F Action obsrvation tratmnt to improv cortical plasticity and uppr limb functions in chronic strok patints: a RCT study from basic nuroscinc to traditional and hom basd clinical rhabilitation. SAN RAFFAELE PISANA FRANCESCHI NI MARCO Clinicoassistnzial Biobhavioral and Bhavioral Procsss Motor Function, Spch and Rhabilitation MFSR Cutanous and utrin lyomyomatosis occurrnc and fumarat hydratas gn xprssion: a potntial nw diagnostic algorithm for th scrning of th risk of cavrnomas and crbrovascular accidnts Lazio Orlandi Augusto Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM A multidisciplinary invstigation on th arly stags of dmntia aimd to idntify oldr popl with cognitiv frailty Vnto GALLUCCI MAURIZIO Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 327 di 356

328 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Evaluation of Biomarkrs of Rsistanc/Snsitivity to diffrnt Adjuvant Endocrin Tratmnts in a Randomizd Trial to Optimiz Tratmnt Dcision Making and to Idntify Novl Pharmacological Targts in Estrogn Rcptor (ER) Positiv Brast Canc PASCALE D Laurntiis Michlino Biomdica Oncology 2 Cancr Biomarkrs Singl chain antibodis and transcription activator lik ffctor protin: a combind biotchnologis for advancd thraputic approach against HIV/AIDS Istituto Suprior di Sanita' Titti Fausto Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Us of lctrical stimulation in th rhabilitation of dysphagia aftr strok: randomizd controlld trial to tst th ffctivnss of tratmnt on outcom Emilia Romagna Antnucci Robrto Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Rgnrativ Ntworks: Influnc of adipos drivd stromal fraction on skin rpair SAN GALLICANO Blli Barbara Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS A POPULATION BASED STUDY ON THE RELATIONSHIP BETWEEN EXPOSURE TO OUTDOOR AIR POLLUTION AND CIRCULATING BIOMARKERS. MAGGIORE MANNUCCI PIER MANNUCCIO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR Phosphotargting of NG2/CSPG4 in Chordoma ISTITUTO TUMORI MILANO Tamborini Elna Clinicoassistnzial Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Slf Expandabl Mtal Stnts As Bridg To Surgry Tratmnt For Acut Malignant Colonic Obstruction Sicilia Di Mitri Robrto Clinicoassistnzial Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Dvlopmnt of synthsis tools for orthopadic surgry using biomatrials basd on custom mad 3D printing tchnology Toscana Calvosa Giuspp Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 328 di 356

329 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv PROJECT TITLE: ArmòniaRsarch action of work rlatd strss and psychosocial risk assssmnt in a Halthcar Enstablismnt Sicilia CREMA MARCO Clinicoassistnzial Risk, Prvntion and Halth Bhavior Social Psychology, Prsonality and Intrprsonal Procsss SPIP Discovry of Tat mimicking compounds to fight HIV latncy Istituto Suprior di Sanita' Sgarbanti Marco Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT TISSUE ENGINEERING IN ORGAN TRASPLANTATION: THE USE OF POLYMERIC SCAFFOLDS IN HEPATIC VASCULAR AND BILIARY RECOSTRUCTION Sicilia Ricotta Calogro Biomdica Surgical Scincs, Antonio Biomdical Imaging, and Carmlo Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Vitamin D to improv cllular killing of HIV 1. SPALLANZANI Nardacci Robrta Biomdica AIDS and Rlatd Rsarch AIDS Discovry and Dvlopmnt of Thraputics ADDT Th impact of th Intrnal Body Prcption and imag in Aging: dvlopmnt of an innovativ tool SANTA LUCIA Lucci Giuliana Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Fractal Lacunarity of Trabcular Bon in Magntic Rsonanc Imags of Lumbar Vrtbras: Validation of a Nw Diagnostic Tool for Ostoporosis and Fractur Risk I.N.R.C.A. Zaia Annamaria Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM Off labl us of sildnafil in nwborn and infants with pulmonary hyprtnsion: pharmacogntic/ pharmacokintic analysis and possibl influnc on cognitiv functions OSPEDALE BAMBINO GESU' tsta giusppina Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Rprogramming and stmnss in ovarian cancr: function, signaturs and clinical rlvanc I.E.O. TESTA GIUSEPPE Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Molcular bass of host pathogn intraction in brucllosis: comparativ study in dairy larg ruminants. IZSME Martuccillo Alssandra Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 329 di 356

330 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Pliotropic ffcts of proprotin convrtas subtilisin kxin typ 9 (PCSK9) targting: focus on xtra hpatic tissus. MULTIMEDICA CATAPANO ALBERICO Biomdica Cardiovascular and LUIGI Rspiratory Scincs Physiology and Pathobiology of Cardiovascular and Rspiratory Systms PPCR A long trm valuation of th impact of a complx intrvntion to support Alzhimr's Disas patints and thir cargivrs. Th "Up Tch 2" projct I.N.R.C.A. Rimland Josph Morton Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Cancr and adolscnc: improv undrstanding of clinical and traslational rsarch C.R.O. AVIANO Mascarin Maurizio Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Analytical dtrmination and xposur assssmnt of nanomatrials in food Istituto Suprior di Sanita' Cubadda Francsco Biomdica Vtrinary Food Safty FOSA Intgratd us of multipl tchniqus for th undrstanding and tratmnt of spatial awarnss and motor disordrs following strok Pimont D Matti Marco Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP A halth Application for th managmnt of Alcohol Us Disordrs: A Randomizd Trial Lazio Addolorato Giovanni Clinicoassistnzial Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA Dvlopmnt of radiolabld amyloid sking agnts basd on protin and pptid scaffolds for PET imaging SAN MATTEO Lodola Lornzo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Mdical Imaging MEDI A nw immunothrapy option for oral mlanoma and othr canin malignant tumors using a DNA vaccin coding for human chondroitin sulphat protoglycan 4 (CSPG4), intgratd with th validation of candidat gn usful for thraputic opportunitis and prog IZSPLV Frrari Anglo Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 330 di 356

331 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Usfulnss of non invasiv tst Gastropanl in ordr to improv th Protonic Pomp Inhibitors (PPIs) administration appropriatnss in ldrly population in Parma ara. Emilia Romagna DI MARIO FRANCESCO Clinicoassistnzial Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB ß D GLUCAN DRIVEN EARLY DE ESCALATION OF ANTIFUNGAL THERAPY IN CRITICALLY ILL PATIENTS: AN INNOVATIVE ANTIFUNGAL STEWARDSHIP PROGRAM Emilia Romagna VIALE PIERLUIGI Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Idntification of novl diagnostic and thraputical targts in th managmnt of patints with polyps and colorctal carcinoma SAN RAFFAELE MILANO Tstoni Pir Albrto Biomdica Oncology 1 Basic Tumor Micronvironmnt TME An intgrativ approach to th dsign of rational targtd thraputics in cholangiocarcinoma REGINA ELENA Grazi Gian Luca Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Nw analytical stratgis to improv food safty: dvlopmnt of fast and high snsitiv mthods, basd on powrful and innovativ matrials, to dtct pathognic bactria and thir toxins IZSME capuano fdrico Biomdica Vtrinary Food Safty FOSA Disscting RBL2/p130 rol in apoptosis, and its intrplay with th AKT pathway, to fully xploit its tumor supprssor potntial thraputically PASCALE Pntimalli Francsca Biomdica Oncology 1 Basic Cancr Molcular Pathobiology CAMP Rol of gut microbioma and circulatingrna in cliac patints Lombardia Lanzini Albrto Biomdica Digstiv, Kidny and Urological Systms, Intgrativ and Molcular Gastrontrology CIMG Patints and citizns involvmnt in Halth Tchnology Assssmnt Agnzia pr i Srvizi Sanitari Rgionali Lo Scalzo Alssandra Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Biotchnological ragnts combind with plasmonic and nanomchanical snsors for improvd foodborn viruss dtction IZSLER PAVONI ENRICO Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 331 di 356

332 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A study dsignd to rplicat th whol xom squncing mdiatd idntification of novl variants involvd in inhibitor dvlopmnt in svr Italian Hmophilia A patints MAGGIORE Pyvandi Flora Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD CDCP1 as a thraputic targt in mtastass of triplngativ brast cancr ISTITUTO TUMORI MILANO Tagliabu Elda Biomdica Oncology 1 Basic Tumor Progrssion and Mtastasis TPM and gntic prdisposition to gliomas and spinal tumors in nurofibromatosis typ 1. CARLO BESTA oli marica Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT OstoCHONdral tissu REGENration by a novl anti INflammatory bi phasic scaffold (CHONREGENIN) GALEAZZI Prtti Giuspp Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE No adjuvant systmic chmothrapy plus intra artrial chmothrapy plus xtrnal capacitiv hyprthrmia followd by prcutanous irrvrsibl lctroporation and than by adjuvant thrapy in locally advancd pancratic cancr: a phas 1 2 clinical trial ONCOLOGICO DI BARI Gadalta Cosmo Damiano Clinicoassistnzial Oncology 2 Oncology CONC Adjunctiv corticostroid tratmnt in critically ill patints with sptic shock. A multicntr randomisd blindd placbo controlld trial of hydrocortison in critically ill patints with sptic shock SAN RAFFAELE MILANO BOVE TIZIANA Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Innovativ thrapy for prcancrous skin lsions : improving fficacy and incrasing patint complianc, whil rducing sid ffcts Emilia Romagna fliciani claudio Biomdica Oncology 2 Dvlopmntal Thraputics DT Dvlopmnt of nw laboratory approachs to idntify immunological markrs in th ovin uddr and milk during infction and vaccination against contagious agalactia. IZSSI Loria Guido Ruggro Biomdica Vtrinary Animal Halth ANHE Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 332 di 356

333 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Comparativ approachs to th molcular immunopathognsis of Paratubrcolosis IZSLER Ricchi Matto Biomdica Vtrinary Animal Halth ANHE Systms Mdicin & Chronic Rhinosinusitis with Nasal Polyps: Host Gnom and its Intractions with Microbiom and Environmnt SAN RAFFAELE MILANO Trimarchi matto Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Prvntion of obsity through prbiotic ffct of plant drivd insulin mimtic substancs SAN RAFFAELE MILANO Trruzzi Ilana Marina Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and Intgrativ Diabts and Obsity CIDO Nurobhavioral problms in autistic spctrum disordr patints undrgoing pdiatric dntistry car: an obsrvational and xprimntal study aimd at an innovativ, tailord approach in spcial nds patints Istituto Suprior di Sanita' Allva Enrico Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Evaluation of patint prfrncs around th diffrnt cancr srvics dimnsions: nwvidncs for improving srvic organisation. Pimont CIUFFREDA LIBERO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD A randomizd clinical trial to valuat th fficacy of Horticultural Thrapy Protocol (HTP) on bhavioral disordrs in popl with mild to modrat Alzhimr s disas. Istituto Suprior di Sanita' Rosmini Francsco Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Environmntal and allrgic factors affcting th prvalnc and th diagnostic thraputic approachs of asthma in childrn MARIO NEGRI Clavnna Antonio Clinicoassistnzial Population Scincs and Epidmiology Infctious Disass, Rproductiv Halth, Asthma and Pulmonary Conditions IRAP : RELATIONSHIP OF GLUCAGON LIKE PEPTIDE 1 WITH DEPRESSION AND COGNITIVE DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES. Toscana Mannucci Edoardo Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Physiology of Obsity and Diabts IPOD Risks of Occupational xposur to Nanomatrials: an intgratd approach to valuat xposur and halth ffcts at workplac INAIL Cavallo Dlia Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 333 di 356

334 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Nw Diagnostic and Thraputic Approachs To Prclampsia: Matrnal Circulating Biomarkrs for Early Diagnosis, Micronutrints Supplmntation and placntal drivd molcular tools Against Placntal Hypoxia, Oxidativ Strss and Endothlial Damag. Pimont TODROS TULLIA Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Sdation Practics in Intnsiv Car Evaluation: Early Goal Dirctd Sdation Compard with Standard Car in Mchanically Vntilatd Patints in Intnsiv Car SAN RAFFAELE MILANO Cabrini Luca Biomdica Cardiovascular and Rspiratory Scincs Lung Injury, Rpair, and Rmodling LIRR IMPACT OF A RESCUE COURSE OF ANTENATAL CORTICOSTEROIDS ON DEVELOPING BRAIN: A RANDOMISED CONTROLLED TRIAL ON SHORT TERM AND LONG TERM OUTCOMES Emilia Romagna RIZZO NICOLA Biomdica Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Dtrminants of halthy aging in th EPIC Italy cohort ISTITUTO TUMORI MILANO Pala Maria Valria Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Modulation of visuospatial awarnss during multitasking in right hmisphr strok patints: towards novl bhavioral and nurofunctional prdictors of impairmnt and rcovry of th attntional ntworks S.CAMILLO Zorzi Marco Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Implmntation and valuation of th Mting Cntrs Support Programm for popl with dmntia and thir carrs (MCSP): cost ffctivnss in Italy DON GNOCCHI Farina Elisabtta Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Novl diagnostic/prognostic prspctivs of 18KDa Translocator Protin (TSPO) masurmnt in an Alzhimr Disas (AD) mous modl: a micropet study. Toscana D'Agata Albrino Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration THE EFFECT OF PRE TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION SAN MATTEO DAL CANTON ANTONIO Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 334 di 356

335 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Dvlopmnt and validation of a production procss for homologous srum y drops and fibrin platlt gl prparation from umbilical cord blood. Vnto D Angli Srgio Biomdica Vascular and Hmatology Erythrocyt and Lukocyt Biology ELB Idntification of nw prognostic/diagnostic markrs of Nuroblastoma: ips clls basd study of Lamin A dysrgulation MULTIMEDICA Rizzi Robrto Biomdica Gns, Gnoms and Gntics Molcular Gntics MGA Protocol for th tratmnt of Critical Limb Ischmia no option thrapy with bon marrow stm cll concntrat harvstd with a point of car dvic Emilia Romagna Stlla Andra Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS PROTECTING THE HEALTH AND DEVELOPMENT OF INFANTS SINCE THE EARLY DAYS : HUMAN VERSUS COWS MILK Campania Raimondi Francsco Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN A nw approach for prvntion of nosocomial infctions: dvlopmnt of advancd protocols and guidlins for intgratd survillanc procdurs basd on molcular monitoring of ndoscops and rusabl dvics. Campania SMERAGLIA RICCARDO Biomdica Infctious Disass and Microbiology Small Businss: Non HIV Infctious Agnt Dtction/Diagnostic s, Food Safty, Strilization/Disinfc tion and Biormdiation SBID Pharmacogntic study on Busulfan and hpatic vnoocclusiv disas in padiatric patints undrgoing hmatopoitic stm cll transplantation BURLO GAROFALO Rabusin Marco Clinicoassistnzial Oncology 2 Cancr Biomarkrs A multicntr study on th diagnosis, immun pathognsis and thrapy of chronic inflammatory dmylinating polyrardiculonuropathy (CIDP) and of its variants HUMANITAS Nobil Orazio Eduardo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT A randomizd approach to dfin th bst tratmnt stratgy for prostat cancr patints with lymphnodal rcurrnc: prsonalizd thrapis or androgn dprivation thrapy? SAN RAFFAELE MILANO Picchio Maria Clinicoassistnzial Oncology 2 Oncology CONC Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 335 di 356

336 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Th xposom of soccr playrs: valuation of potntial halth risks associatd with xposur to Substancs of Vry High Concrn (SVHC) idntifid in th framwork of th REACH Rgulation and to othr chmicals of concrn. Istituto Suprior di Sanita' draisci rosa Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM A NOVEL INTEGRATED GENOMIC AND IMMUNOLOGICAL STRATEGY FOR THE THERAPY OF CHRONIC HEPATITIS B Emilia Romagna Frrari Carlo Biomdica Immunology Immunity and Host Dfns IHD Evaluation of th anti tumor ffcts and mchanisms of antirtroviral drugs in crvical cancr: prclinical and human studis Istituto Suprior di Sanita' Sgadari Ccilia Biomdica Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Circulating Endothlial Prognitor Clls and Aquaporins as prdictiv biomarkrs of onst and growth of hmangioblastomas and cysts in von Hippl Lindau disas. Emilia Romagna Pavsi Giacomo Biomdica Oncology 2 Cancr Biomarkrs Assssmnt of th risk for consumrs xposd to palytoxins contaminatd safood in th prsnc of Ostropsis cf. ovata bloom along th Italian coasts Istituto Suprior di Sanita' Tstai Emanula Biomdica Vtrinary Food Safty FOSA Cll intrinsic and xtrinsic mchanisms sustaining chmorfractorinss in Diffus Larg B Cll Lymphoma (DLBCL) and classical Hodgkin Lymphoma (chl): implications for diagnosis and thraputic targting HUMANITAS LOCATI MASSIMO Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Th rol of 3TMRI HIFU in th priostal nurolysis of th productiv lytic bon mtastats CROB CAMMAROTA ALDO Clinicoassistnzial Oncology 2 Radiation Thraputics and Biology RTB Innovativ approach to HIFU tratmnts for halth car costs rduction and patint complianc improvmnt. Sicilia Bartolotta Tommaso Biomdica Surgical Scincs, Vincnzo Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 336 di 356

337 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rsarch, dsign, analysis, dvlopmnt, tst and tuning of a wb basd informatic systm to b usd vn on Tablt Android to support and coordinat all activitis of inspction, monitoring and sampling In th fild of occupational safty, building sits Lazio FIRICANO IRENE Biomdica Halthcar Dlivry and Mthodologis Halth and Halth Rlatd Bhavior of Individuals and Populations Fllowship F Mapping th multisnsory natur of th primary visual and auditory cortics with intracranial EEG and fmri CARLO BESTA bruzzon maria grazia Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Cognitiv Nuroscinc COG Evaluation of two diffrnt postpartum and post abortion rublla vaccination protocols in a sampl of Italian hospitals. Istituto Suprior di Sanita' Rota Maria Cristina Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS GENOTYPING OF POLYMORPHISM OF RS NOS C IN A COHORT OF MEN AFFECTED BY ERECTILE DYSFUNCTION AND ANALYSIS OF ITS IMPACT ON THE RESPONSE TO THERAPY WITH PDE5 I SAN RAFFAELE MILANO Salonia Andra Clinicoassistnzial Digstiv, Kidny and Urological Systms Urologic and Kidny Dvlopmnt and Gnitourinary Disass UKGD Evaluating Atrial Fibrillation and Rlatd Outcoms Using a Validatd Halthcar Databas. Effctivnss of Nw vs Old Anticoagulants and Physicians' Prscription Bhavior. Umbria Abraha Iosif Clinicoassistnzial Population Scincs and Epidmiology Cardiovascular and Slp Epidmiology CASE Adaptiv radiothrapy concomitant with chmothrapy in proprativ tratmnt of rctal adnocarcinoma. Dos finding and clinical fficacy of adaptiv radiothrapy; assssmnt of radiologic, functional, and gntic paramtrs prdicting pathologic complt SAN RAFFAELE MILANO Passoni Paolo Clinicoassistnzial Oncology 2 Oncology CONC METABOLOMIC ANALYSIS IN HUMAN URINE TO IDENTIFY PROGNOSTIC BIOMARKERS OF PRETERM LABOR AND PRETERM PRELABOUR RUPTURE OF MEMBRANES. Sardgna MELONI ALESSANDRA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Prgnancy and Nonatology PN Charactrization of multidrug rsistant (MDR) Klbsilla pnumonia strains in Sicilian animals compard with clinical isolats IZSSI Costa Antonlla Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 337 di 356

338 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Effct of adaptd physical activity (APA) training programs on xrcis tolranc, cardio pulmonary functionality, muscl strngth, symptoms, inflammatory cytokins rspons, quality of lif in subjcts affctd by multipl sclrosis (MS). SANTA LUCIA Dlussu Anna Sofia Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Early discharg and rmot managmnt of hart failur patint at "Policlinico Casilino" Lazio D'ESTE GIORGIO Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Addrssing th pancratic bta clls for th prvntion and tratmnt of typ 2 diabts Toscana Marchtti Piro Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Molcular and Cllular Endocrinology MCE Brain mapping in aslp conditions in th tratmnt of high grad gliomas in th languag aras CARLO BESTA Lgnani Fdrico Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT MicroRNA: nw markrs for th diagnosis of occult hpatitis B Istituto Suprior di Sanita' Marcantonio Cinzia Biomdica Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Abruzzo Porzio Giampiro Mobil halth car systm for symptoms monitoring in patints with mtastatic brast cancr rcving targtdtrapy Clinicoassistnzial Oncology 2 Oncology CONC Intgratd/tird approach as a tool for valuating potntial toxicity of nanomatrials of concrn for human halth. Idntification of rlvant biomarkrs for immun, rproductiv, ndocrin and gno toxicity Istituto Suprior di Sanita' Maranghi Francsca Biomdica Bionginring Scincs and Tchnologis Nanotchnology NANO Anti biopharmacutical immunization: valuation of immunognicity of biological agnts in immunomdiatd disass through th dtction of anti drug antibodis, analysis of its clinical rlvanc and risk factors Toscana vultaggio alssandra Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 338 di 356

339 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Intnsification with dolutgravir in patints who hav a stably supprssd HIV 1 virmia during boostd ritonavir protas inhibitor monothrapy (Dolutgravir Protas Inhibitor Monothrapy Intnsification DOLPHIN Study) SPALLANZANI Antinori Andra Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE A multiparamtric and risk basd monitoring approach to support clinical dcision in pdiatric cardiac intnsiv car OSPEDALE BAMBINO GESU' Cogo Paola Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS THE TASTE OF BACTERIA : Idntifying th TAS2R38 gnotypic risk of rcurrnc of uppr rspiratory infctions. Campania Lon Carlo Antonio Biomdica Infctious Disass and Microbiology Host Intractions with Bactrial Pathogns HIBP Ktognic dit in th tratmnt of child drug rsistant pilpsis: a longitudinal multicntr study on mtabolic factors and pigntic prdictors of fficacy and tolrability MONDINO Vggiotti Piranglo Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Eracl: daring with motions. Psychological support in th srvics of cancr patints and thir familis Sicilia DI PASQUALE ANGELA Clinicoassistnzial Oncology 2 Oncology CONC Undrstanding th molcular bass of congnital hart dfcts: from gn discovry to molcular diagnosis OSPEDALE BAMBINO GESU' Digilio Maria Cristina Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD IDENTIFICATION OF GENETIC ALTERATIONS ASSOCIATED WITH SECOND MALIGNANT NEOPLASMS HUMANITAS SANTORO ARMANDO Biomdica Oncology 1 Basic Cancr Gntics CG Intgrating srum mtabolomic, circulating micrornas profiling and adrnomdullin lvls in arly scrning of pancratic carcinoma in nw onst diabts patints Lazio D'Anglo Francsco Biomdica Oncology 2 Antonio Cancr Biomarkrs Dvlopmnt of pr oprativ invstigation tools and surgical procdurs for th tratmnt of movmnt disordrs in childhood OSPEDALE BAMBINO GESU' Marras Carlo Efisio Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmntal Brain Disordrs DBD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 339 di 356

340 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv THE IMPACT OF SONICATION ON INFECTION DIAGNOSIS AND TREATMENT. SAN MATTEO BENAZZO FRANCESCO Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Cardiac dysfunction inducd by tyrosin kinas inhibitors: from arly diagnosis to thrapy Sicilia siragusa srgio Clinicoassistnzial Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Lung transthoracic US lastography imaging and contrast imaging US: a comparisonaddrssd to US guidd biopsis of subplural cancr Sicilia Trovato Guglilmo Clinicoassistnzial Oncology 2 Oncology CONC Gndr rlatd comparisons of lif habits, frtil lif charactristics and advancd MRI paramtrs in multipl sclrosis Sicilia Ragons Paolo Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT Involvmnt of cytosklton protins in mdiating pulmonary nurondocrin tumors clinical prsntation and progrssion HUMANITAS Lania Andra Grardo Biomdica Oncology 1 Basic Antonio Tumor Progrssion and Mtastasis TPM Randomizd controlld study on th valuation of rhabilitation tratmnts for mild cognitiv impairmnt in patints with rlapsing rmitting and scondary progrssiv multipl sclrosis Istituto Scinz Nurologich maffi monica Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration semg dscriptors of fatigu as outcom masurs in facioscapulohumral dystrophy: analysis of th ffcts of branchd chain amino acid supplmntation MAGGIORE Moggio Maurizio Gualtiro Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Musculoskltal Rhabilitation Scincs MRS Biological faturs,rol of biomarkrs and xtnt of surgical rsction in Right Colon Cancr: idntification of a scor of probability of local and mtastatic sprad for prsonalizd surgry Emilia Romagna Anania Gabril Biomdica Oncology 2 Cancr Biomarkrs Transmissibility and clinical significanc of Mycobactrium abscssus in patints with cystic fibrosis MAGGIORE Cariani Lisa Biomdica Infctious Disass and Microbiology Bactrial Pathognsis BACP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 340 di 356

341 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Evaluation of monoamin oxidas A (MAO) as a targt for tratmnt of Prostat Cancr. I.E.O. NOLE' FRANCO Clinicoassistnzial Oncology 2 Oncology CONC Effcts of matrnal nutrition during prgnancy on ftal pigntic profil: st up of a rsarch infrastructur. MAGGIORE Bosari Silvano Biomdica Halthcar Dlivry and Mthodologis Halth and Halth Rlatd Bhavior of Individuals and Populations Fllowship F Nw molcular dp squncing approach for minimal rsidual disas dtction in adult Acut Lymphoblastic Lukmia patints for risk stratification and tratmnt dfinition. Lombardia Rambaldi Alssandro Clinicoassistnzial Oncology 2 Cancr Biomarkrs Auditory survillanc: dsigning tools and protocols for an ffctiv follow up aftr nwborn haring scrning BURLO GAROFALO Orzan Eva Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Auditory Systm AUD AN INNOVATIVE TECHNOLOGICAL MODEL FOR REHABILITATION OF CHILDREN WITH CEREBRAL PALSY: VIRTUAL REALITY (VR), VIDEO GAMES AND ON LINE TUTORING FOR COORDINATIVE TRAINING AND HOME CARE ASSISTANCE. EFFICACY AND COST AFFORDANCE MEDEA TURCONI ANNA CARLA Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Nurotchnology NT A mdical dvics submission tmplat for th Italian contxt (TmplaIT) Agnzia pr i Srvizi Sanitari Rgionali Crbo Marina Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD A molcularly basd diagnostic and pharmacological approach to IgA nphropathy Lazio Gambaro Giovanni Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Pntraxin 3: a novl biomarkr for diagnosing prostat cancr. A validation study. Puglia Raniri Elna Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 341 di 356

342 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Slctiv uprgulation of KIR rcptors by hrpsvirus infction: a novl pathogntic mchanism in multipl Sclrosis SAN RAFFAELE MILANO Malnati Mauro Biomdica Brain Disordrs and Nuroscinc Nuroimmunology and Brain Tumors CNBT PROSPECTIVE MULTICENTER STUDY ON RESEARCH AND VALIDATION OF PREDICTIVE BIOMARKERS OF RESPONSE TO AZACITIDINE IN PATIENTS WITH HIGH RISK MYELODYSPLASTIC SYNDROMES. Emilia Romagna Finlli Carlo Biomdica Oncology 2 Cancr Biomarkrs Idntification of arly markrs of Panic Disordr: a gnby nviromnt invstigation in a dvlopmntal framwork. SAN RAFFAELE MILANO Bllodi Laura Biomdica Brain Disordrs and Nuroscinc Pathophysiological Basis of Mntal Disordrs and Addictions PMDA ROLE OF NGF IN CHRONIC ALLOGRAFT NEPHROPATY Calabria Bonofiglio Rnzo Biomdica Digstiv, Kidny and Urological Systms Pathobiology of Kidny Disas PBKD Ischmic Prconditioning and th vascular rspons to ischmia in chronic kidny disas (CKD) patints (PROTECT CKD) Calabria Panuccio Vincnzo Antonio Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Nw stratgis for diagnostic, thraputic and clinical car in Infctious and immunological disass OSPEDALE BAMBINO GESU' Fiocchi Alssandro Biomdica Immunology Hyprsnsitivity, Autoimmun, and Immun Influnza pathways: rlas and xposur assssmnt to idntify th virus maintnanc stratgis IZSPLV MAURELLA CRISTIANA Biomdica Vtrinary Animal Halth ANHE Improvmnt of diagnostic accuracy of FNA and brushing citology by FISH tchniqu and K ras mutation analysis in patints with suspctd pancrato biliary malignancis Friuli Vnzia Giulia Bulajic Milutin Clinicoassistnzial Oncology 2 Cancr Biomarkrs Rol of GluD1 in Rtt syndrom: studis in a murin modl and human ips clls MARIO NEGRI Invrnizzi Robrto William Biomdica Gns, Gnoms and Gntics Thraputic Approachs to Gntic Disass TAG Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 342 di 356

343 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A Knowldg Translation Platform for masuring rhabilitation outcoms and cost for patints in car pathways Friuli Vnzia Giulia Saccavini Marsilio Clinicoassistnzial Biobhavioral and Bhavioral Procsss Motor Function, Spch and Rhabilitation MFSR A rsarch to improv th prdictability in th mammography scrning protocol Sicilia BENNICI ELIO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Computational modling and scincs for biomdical and clinical applications ZRCM GENOTYPE PHENOTYPE CORRELATION FOR MAGNETIC RESONANCE IMAGING FEATURES OF MOWAT WILSON SYNDROME WITH ZEB2 MUTATION/DELETION; A NEW INTERNATIONAL DATABASE AND FUTURE DISCOVERIES OF THE ROLE OF THE GENE ZEB2 IN THE DEVELOPMENT OF THE HUMAN BRAIN ARCISPEDALE garavlli livia Clinicoassistnzial Biobhavioral and Bhavioral Procsss Child Psychopathology and Dvlopmntal Disabilitis CPDD RISK FACTORS FOR INVASIVE CANDIDIASIS IN INTERNAL MEDICINE AND GERIATRIC UNITS Puglia Srviddio Gatano Clinicoassistnzial Infctious Disass and Microbiology Rsarch and Fild Studis of Infctious Disass CRFS Is rmot mmory impairmnt in amnstic Mild Cognitiv Impairmnt a prdictor of convrsion to Alzhimr's dmntia? CARLO BESTA Tiraboschi Pitro Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Evaluation of nonatal fding on gut microbiota shaping: th nutritional valu of milks addd by bioactiv molculs OSPEDALE BAMBINO GESU' Putignani Lornza Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Lifstyls, risk factors, and mrging biomarkrs for th prdiction of chronic non communicabl disass in th gnral adult population Istituto Suprior di Sanita' Palmiri Luigi Clinicoassistnzial Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM1 Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 343 di 356

344 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Slp in Subjctiv Mmory Impairmnt (SMI) as a prclinical stag of Alzhimr Disas: a nuroimaging study NEUROMED Grammaldo Liliana gracila Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Cardiovascular disass and impact of comorbid rspiratory disass (CADICORD) Umbria Rboldi Gianpaolo Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Gnom wid association study on Follicular lymphoma ONCOLOGICO DI BARI Guarini Attilio Biomdica Oncology 2 Cancr Biomarkrs Effcts of diffrnt nutritional supports on muscular and mtabolic outcoms in sarcopnic and pr sarcopnic patints with typ 2 diabts mllitus as add on to nuromuscular training pr Total Joint Rplacmnt Pimont Broglio Fabio Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intgrativ Nutrition and Mtabolic Procsss INMP Dvlopmnt of a modl of cardiac survillanc for cancr patints candidats to molcular targtd agnts thrapis. Campania Pp Stfano Clinicoassistnzial Oncology 2 Oncology CONC GENtic suscptibility, Thrombin gnration and whol blood viscolasticity assays: a nw intgrativ thranostic approach for hamostasis managmnt of PEdiatric patints with congnital disas (GENoTYPE) Toscana Botto Nicoltta Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Food safty in childrn nutrition. Exposur of young childrn to chmicals migratd from tablwar into foods: xtnsiv study on migration, risk charactrization and risk assssmnt. Istituto Suprior di Sanita' milana maria rosaria Biomdica Risk, Prvntion and Halth Bhavior SBIR/STTR: Risk Prvntion and Halth Bhavior across th Lifspan TPM Monitoring infction in complx wounds in pdiatric patints. Nw stratgis and modl for diagnostic, thraputic and clinical car for prvntion of infction OSPEDALE BAMBINO GESU' blla srgio Clinicoassistnzial Halthcar Dlivry and Mthodologis Nursing Scinc: Childrn and Familis NSCF Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 344 di 356

345 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Falls Prvntion in hospitals and long trm car through intllignt vido survillanc and monitoring of fallrlatd bhavioral pattrns. Liguria Cardinal Francsco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Evaluation of cognitiv impairmnt in patints with svr stnosis of th xtracranial carotid artris: bnficial ffcts of carotid artry stnting (CAS) Campania Rubino Paolo Biomdica Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS Th fficacy of tratmnts of pri implant disass on oral halth SAN RAFFAELE MILANO Ghrlon Enrico Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT IDENTIFICATION OF NEW STRATEGIES TO IMPROVE THE OUTCOME OF TRAUMATICBRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEWTARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Sicilia Cuzzocra Salvator Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Estrogn dpndnt M1/M2 macrophag balanc as a novl cardiovascular risk biomarkr in rlation to hormonal status and pathological amnorrha in frtil womn Vnto Scaroni Carla Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F PREVENTION OF REPEATED FIRST TRIMESTER VOLUNTARY ABORTION AMONG WOMEN WITH LOW CONTRACEPTIVE COMPLIANCE IMPROVES REPRODUCTIVE HEALTH AND REDUCES SOCIAL AND HOSPITAL COSTS Sicilia GIAMBANCO LAURA Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Virtual surgry to optimiz th oprativ procdur and improv th outcom in hart failur patints undrgoing surgical rshaping of th lft vntricl. SAN DONATO Castlvcchio Srnlla Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 345 di 356

346 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Transcriptional rgulatory ntworks in multipl sclrosis SAN RAFFAELE MILANO Farina Cinthia Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Cognition and movmnt: bhavioural and brain rsponss to a mixd cognitiv and motor training in individuals with Parkinson's disas SANTA LUCIA Costa Albrto Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Epignomics of padiatric multipl sclrosis Sicilia Grimaldi Luigi Biomdica Gns, Gnoms and Gntics Gnomics, Computational Biology and Tchnology GCAT Improving clinical car, optimizing th rsarch ntwork for nurological patints: a Novl ORganizational MAtrix (NORMA). CARLO BESTA Cornlio Frdinando Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Th complmnt and coagulation systms: contribution to ischmia and microthrombosis in subarachnoid hmorrhag MAGGIORE Stocchtti Nino Biomdica Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Vitamin E, mirna and inflammation: a tunabl ntwork in Alzhimr's disas. Umbria Mcocci Patrizia Biomdica Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Rsarch projct for idntification and valuation of a nw tchnical and organizational modl abl to nsur complianc with suspnsion tim aftr slaughtr in livstock in trms of Pharmacosurvillanc, using a systm dvlopd in wb tchnology and hig Lazio sciscion umbrto Biomdica Vtrinary Food Safty FOSA Studio multicntrico ossrvazional sull'pidmiologia l'outcom dll'arrsto cardiaco in Italia. Efftti dll'implmntazion di una rilvazion sistmatica sull'sito. Emilia Romagna Crchiari Erga Laura Biomdica Halthcar Dlivry and Errica Mthodologis Halth Srvics Organization and Dlivry HSOD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 346 di 356

347 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Monitoring and biofdback for postur analysis on th workplac Istituto Suprior di Sanita' Morlli Sandra Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Comparison btwn hospital admission and arly discharg from th mrgncy dpartmnt of nursinghom dwlling oldr popl diagnosd with pnumonia: a randomizd clinical trial Toscana Monzani Fabio Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Population basd pidmiology of arly acquird disabilitis: to qualify and quantify th unmt car nds of disabld individuals, to xplor th implmntation of targtd and innovativ intrvntion. Abruzzo ZULLI FILIPPO Clinicoassistnzial Population Scincs and Epidmiology Social Scincs and Population Studis SSPS Hony bs as a sntinl spcis for PAHs nvironmntal contamination IZSVE Mutinlli Franco Biomdica Vtrinary Food Safty FOSA Evaluation of diagnostic accuracy in intrprtation of scrning mammograms: dvlopmnt of advancd ddicatd softwar ISTITUTO TUMORI MILANO PANIZZA PIETRO Clinicoassistnzial Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Rducing ovrwight and obsity in patints as a stratgy to improv disas activity and svrity and to rduc th nd for biological drugs in chronic inflammatory rhumatic disass. Lazio Grms Elisa Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Nonatal cardioplgia projct (NECAP): invstigations on protction of ischmic immatur harts. Emilia Romagna Angli Emanula Biomdica Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM and Exprimntal Pathway to Vitiligo Managmnt SAN GALLICANO LEONE GIOVANNI Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Risk assssmnt from tattoos and lasr tattoo rmoval: valuation of drmal toxicity, cll toxicity and gn toxicity of nano and micro substancs SAN GALLICANO Cristaudo Antonio Biomdica Risk, Prvntion and Halth Bhavior Risk, Prvntion and Intrvntion for Addictions RPIA Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 347 di 356

348 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Study on th crbllar rol in Pathological Gambling: an insight into th nurobiological bass of th Impuls Control Disordrs. SANTA LUCIA Lggio Maria Clinicoassistnzial Brain Disordrs and Nuroscinc Nural Basis of Psychopathology, Addictions and Slp Disordrs NPAS Exploring th link btwn antnatal matrnal dprssion and infants bio bhavioral rgulation MEDEA Frigrio Alssandra Biomdica Biobhavioral and Bhavioral Procsss Biobhavioral Mchanisms of Emotion, Strss and Halth MESH Liquid biopsis to dtct microscopic rsidual disas and monitor its volution aftr surgry for arly brast cancr Istituto Scintifico Romagnolo ROCCA ANDREA Biomdica Oncology 2 Cancr Biomarkrs Dvlopmnt of a dos rport softwar and its application in ach radiology dpartmnt of Sicilian Public Hospitals Sicilia Brancatlli Giuspp Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Biomdical Imaging Tchnology BMIT Dtction of prdictiv markrs for thraputic stratification of salivary glands tumors PASCALE LONGO FRANCESCO Clinicoassistnzial Oncology 2 Cancr Biomarkrs Gn xprssion profiling and protomic analysis on tndons and singl muscl fibrs from childrn with Crbral Palsy HUMANITAS portinaro nicola Biomdica Musculoskltal, Oral and Skin Scincs Skltal Biology Structur and Rgnration SBSR Association btwn childhood xposur to phthalats and bisphnol A, subclinical hypothyroidism and cardiomtabolic risk OSPEDALE BAMBINO GESU' Cianfarani Stfano Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs (EMNR) Intgratd Rviw Group Fllowship Panl F corrlats of crbral amyloid burdn in subjcts with nurodgnrativ cognitiv dclin SANTA LUCIA Cravllo Luca Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 348 di 356

349 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv NOVEL AND SELECTIVE ANTITUMOR STRATEGIES FOR THE TREATMENT OF MALIGNANT MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Lacal Pdro Migul Biomdica Oncology 2 Dvlopmntal Thraputics DT EPINEPHRINE (ADRENALINE) REFORMULATION IN IMPROVED STABILITY DRUG DELIVERY SYSTEMS, FOR INNOVATIVE USE IN EMERGENCY SITUATIONS SAN MATTEO Imbrti Robrto Biomdica Bionginring Scincs and Tchnologis Biomatrials and Biointrfacs BMBI Mtabolic rprogramming as thraputic stratgy to amliorat skltal muscl tissu nginring procdurs. SAN RAFFAELE PISANA Gargioli Csar Biomdica Musculoskltal, Oral and Skin Scincs Musculoskltal Tissu Enginring MTE High dnsity of tumor associatd macrophags (TAM) prdicts th rsponsivnss of stag III colorctal cancr (CRC) to adjuvant chmothrapy. HUMANITAS LAGHI LUIGI ANDREA GIUSEPPE Clinicoassistnzial Oncology 2 Oncology CONC A pilot study of prthraputic sorafnib valuation in primary clls, and in tumor xnografts, in papillary aggrssiv thyroid cancr. Toscana Miccoli Paolo Biomdica Oncology 2 Oncology CONC Quality of lif in prsons with svr traumatic brain injury and thir cargivrs SANTA LUCIA Bivona Umbrto Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Nw Computational Tools for Patint Safty in IntraOprativ Elctron Radiation Thrapy Umbria Maranzano Ernsto Biomdica Oncology 2 Oncology 2 Small Businss [SBIR/STTR] Radiation Thrapy and Biology SETA] Strngth arobic training to trat priphral artrial disas: a nw approach to contrast athrosclrosis and disability. Vnto D Marchi Srgio Clinicoassistnzial Cardiovascular and Rspiratory Scincs and Intgrativ Cardiovascular Scincs CICS PREDICTION OF HIGH GRADE GLIOMAS GENOMIC SUBTYPES BY MEANS OF ADVANCED MAGNETIC RESONANCE IMAGING BIOMARKERS CASA SOLLIEVO SOFFERENZA Popolizio Trsa Biomdica Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 349 di 356

350 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Exploitation of ctdna (liquid biopsy) for thraputic dcision in mcrc Istituto Oncologico Candiolo Lon Francsco Biomdica Oncology 2 Cancr Biomarkrs A nw diagnostic tool basd on Raman spctroscopy for fast, asy and chap dtrmination of plasmatic concntrations of antipilptic drugs CARLO BESTA Ciusani Emilio Clinicoassistnzial Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Rmot ischmic prconditiong in patints undrgoing non cardiac surgry. A multicntr randomizd trial. SAN RAFFAELE MILANO Landoni Giovanni Clinicoassistnzial Cardiovascular and Rspiratory Scincs Myocardial Ischmia and Mtabolism MIM Towards prcision mdicin for patints with biliary tract cancrs: tailord tratmnts basd on th mutational profil dtctd on tumor lsions and monitord in liquid biopsis (circulating tumor clls, CTC, and circulating tumor DNA, ctdna) ISTITUTO TUMORI MILANO Daidon Maria Grazia Clinicoassistnzial Oncology 2 Cancr Biomarkrs Fatty acids in brast milk and prinatal xposurs to mtals and organic compounds may prdict child nuropsychological scors at 18 months in a mothr child cohort of 900 Friuli Vnzia Giulia BARBONE FABIO Clinicoassistnzial Population Scincs and Epidmiology Nurological, Aging and Musculoskltal Epidmiology NAME From nocicption to pain in disordrs of consciousnss (DoC) following svr acquird brain injury (ABI) SANTA LUCIA Buzzi Maria Gabrilla Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Building a putativ univrsal modl for immun modulation of virus rlatd tumors: th rol of cll thrapy in had and nck cancr SAN MATTEO Basso Sabrina Clinicoassistnzial Oncology 2 Cancr Immunopathology and Immunothrapy CII Gntic and nvironmntal dtrminants of lft vntricular mass and artrial function: a twin study Umbria Pucci Giacomo Biomdica Cardiovascular and Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Elucidating molcular and functional intractions btwn stroids and histon dactylas inhibitors in th tratmnt of nuromuscular disordrs SANTA LUCIA Puri Pir Lornzo Biomdica Musculoskltal, Oral and Skin Scincs Skltal Muscl Biology and Exrcis Physiology SMEP Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 350 di 356

351 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Mchanical vntilation guidd by osophagal prssur in svr burn patints. Pimont Brardino Maurizio Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Improving Prognostic Accuracy in Svr Traumatic Brain Injury using advancd nuroimaging mthods and multivariat prognostic modling MAGGIORE Magnoni Sandra Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Volatil Organic Compounds analysis for arly stag lung cancr diagnosis. ARCISPEDALE Lococo Filippo Biomdica Oncology 2 Cancr Biomarkrs Early vrticalization using ERIGO may improv functional and cognitiv outcom following Svr Acquird Brain Injury NEUROLESI Bramanti Placido Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Pdiatric pilpsy: clinical and gnomic diagnosis. Application of ILAE 2013 tratmnt guidlins and validation of th rsults in pdiatric pilptic patints. Sicilia Pavon Piro Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Multicntr, opn, randomizd, prospctiv study for th valuation of safty and fficacy of normothrmic machin prfusion for organ prsrvation (Mtra ) in livr transplantation Toscana D Simon Paolo Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Surgry, Ansthsiology, and Trauma SAT Effcts on brain xcitability of antibodis drivd from pilptognic autoimmun ncphalitis CARLO BESTA Librizzi Laura Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Msnchimal stm cll drivd xtracllular vsicls as pharmacutical tool for th tratmnt and prvntion of pilpsy du to brain inflammation. OSPEDALE BAMBINO GESU' Vigvano Fdrico Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE IDENTIFICATION OF A CIRCULATING micrornas SIGNATURE ABLE TO PREDICT RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN ADVANCED OVARIAN CANCER Umbria Fagotti Anna Clinicoassistnzial Oncology 2 Cancr Biomarkrs Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 351 di 356

352 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv A study to improv rmovabl dntur adhsion with oral mucosa: from th molcular basis to translational applications Pimont CERUTI PAOLA Biomdica Musculoskltal, Oral and Skin Scincs Oral, Dntal and Craniofacial Scincs ODCS Giv scrning a chanc SAN MATTEO Bruntti Enrico Clinicoassistnzial AIDS and Rlatd Rsarch AIDS Studis and Epidmiology ACE Epilptic sizurs prdiction through nonlinar dynamic analysis of EEG signals Sardgna Tamburini Giorgio Biomdica Brain Disordrs and Nuroscinc Acut Nural Injury and Epilpsy ANIE Brain and Hart (BraH): vidncs and biomarkrs that corrlat with cardiac and brain intgrity or with disas. A population basd study in th Cntnarians in Trist to prdict succssful aging. Friuli Vnzia Giulia Di Lnarda Andra Clinicoassistnzial Biology of Dvlopmnt and Aging Aging Systms and Griatrics ASG Th nw implmntation of EUntHTA Cor Modl by intgrating th Analytic Hirarchy Procss: a validation of this mthodology usd in halth tchnology assssmnt for supporting halth car dcision making and its application for driving th procss of ad OSPEDALE BAMBINO GESU' Drrico Pitro Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Human Ewing Sarcoma Family Tumor (ESFT) Rvisitd From Cancr Stm Clls (CSCs) toth Epigntic Rgulation: cross talk btwn ncrna and DNA mthylation Lombardia Parafioriti Antonina Biomdica Oncology 1 Basic Tumor Cll Biology TCB Dvlopmnt of miniaturizd assays for th timly diagnosis of rar disass Pimont ROCCATELLO DARIO Biomdica Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Rcognition of a spcific mtabolic fingrprint of diabtic cardiomyopathy, in ordr to clarify its pathophysiology, dlay clinical manifstations of disas and improv th tratmnt Sardgna Cadddu Christian Biomdica Cardiovascular and Dssalvi Rspiratory Scincs Cardiac Contractility, Hyprtrophy, and Failur CCHF Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 352 di 356

353 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Rsarch projct on Colony Collaps Disordr on apiaris basd on th storag into a singl rgional databas of all rsults of sampling and information rgistris, halth car and go rfrncd positions, using wb tchnologis and accssd vn by tabl Lazio CIPOLLONE BRUNO Biomdica Vtrinary Animal Halth ANHE Ticagrlor vs. aspirin for prvntion of cardiovascular vnts in aspirin tratd patints with strok or TIA. Umbria Paciaroni Maurizio Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Molcular mchanisms mdiating mtastasis in rnal angiomyolipoma and lymphangioliomyomatosis formation: possibl clus for idntification of nw pharmacological tratmnts Pimont Porpiglia Francsco Biomdica Digstiv, Kidny and Urological Systms Cllular and Molcular Biology of th Kidny CMBK Study of gn xprssion of th major allrgns producd by Anisakis snsu lato for risk assssmnt in fishry products of gratst commrcial intrst along Tyrrhnian coast Evaluation of th rol of pathogns and nvironmntal factors in dtrmining Unusual Mortality Evnts (UMEs) of ctacans in th Mditrranan, and dvlopmnt of a UMEs prdictiv modl IZSLT Fichi Gianluca Biomdica Vtrinary Food Safty FOSA IZSPLV Mignon Waltr Biomdica Vtrinary Animal Halth ANHE Impact of Tlmdicin in th managmnt of vry ldrly patints affctd by svr chronic hart failur: clinical outcoms, conomic and quality of lif analysis I.N.R.C.A. Antoniclli Robrto Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD This study aims to invstigat th bioavailability, fficacy and safty of pdiatric frindly formulation not commrcially availabl, cntrally prpard by th Hospital Pharmacy OSPEDALE BAMBINO GESU' Corstti Tiziana Clinicoassistnzial Bionginring Scincs and Tchnologis Gn and Drug Dlivry Systms GDD Virtual Rality Simulator and Computr Guiding Systm for ndoscopic and robotic platforms Lombardia Forgion Antonllo Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 353 di 356

354 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv INCIDENCE OF OSTEONECROSIS OF THE JAW IN PATIENTS IN THERAPY WITH DENOSUMAB AND ANTIANGIOGENIC DRUGS: AN OBSERVATIONAL STUDY SAN MATTEO forni franco Clinicoassistnzial Oncology 2 Basic Mchanisms of Cancr Thraputics BMCT Novl biomarkrs of rcurrnc and druggabl pathways to prvnt tumor rlaps inarly stag non small cll lung cancr (NSCLC) patints Umbria Crinò Lucio Clinicoassistnzial Oncology 1 Basic Tumor Micronvironmnt TME Prformanc of univrsal Lynch Syndrom scrning using Mismatch Rpair (MMR) Immunohistochmical tst ISTITUTO TUMORI MILANO Sala Paola Clinicoassistnzial Oncology 2 Cancr Biomarkrs Effctivnss and cost/ffctiv solutions for non slfsufficint popl SANTA LUCIA salvia antonino Clinicoassistnzial Brain Disordrs and Nuroscinc Brain Injury and Nurovascular Pathologis BINP Targting macrophag polarization to ovrcom trabctdin rsistanc in myxoid liposarcoma. Lazio Vincnzi Bruno Biomdica Oncology 1 Basic Tumor Micronvironmnt TME Halth Tchnology Assssmnt of advrs drug ractions: clinical, conomical and organizational impact in a rgional halth systm Lazio Marchtti Marco Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Looking for spontanous prion disass in wild typ bank vols: a nw animal modl for sporadic, ag rlatd, nurodgnrativ disordrs Istituto Suprior di Sanita' Nonno Romolo Biomdica Brain Disordrs and Nuroscinc Cll Dath in Nurodgnration CDIN On Halth Approach for Listriosis: intgration of th xisting laboratory survillanc and control activitis in th mdical and food/vtrinary sctors Istituto Suprior di Sanita' Gianfrancschi Monica Virginia Biomdica Vtrinary Food Safty FOSA Dvlopmnt and institution of a rar cancrs ntwork in th "Rgion Abruzzo" Abruzzo Natoli Clara Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC MULTI MODAL CHARACTERISATION OF CORTICO SPINAL TRACT LESIONS DON GNOCCHI Rabufftti Marco Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Snsorimotor Intgration SMI Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 354 di 356

355 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Biosafty in shllfish farming: study of mrging zoonoss and application of an intgratd modl for biological risk managmnt in livstock production, food scurity and nvironmntal assssmnt in supply chains IZSSA Virgilio Sbastiano Biomdica Vtrinary Food Safty FOSA Tissu nginrd gut as a novl modl to study th mchanisms of Crohn s disas intstinal fibrosis SAN MATTEO Di Sabatino Antonio Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Cration of a nw nxt gnration panl for th diagnosis of Mitochondrial disordrs with nuromuscular phnotyp Associazion Oasi Maria SS Scudri Carmla Biomdica Gns, Gnoms and Gntics Gntics of Halth and Disas GHD UltraSound, Contrast Enhancd UltraSound (CEUS) and 5 aminolvulinic acid (5 ALA) in tumour dtction at th bordr of high grad gliomas: A prospctiv study basd on a histopathological assssmnt. CARLO BESTA DiMco Francsco Clinicoassistnzial Oncology 2 Oncology CONC BIOENGINEERING OF A NOVEL CORNEAL DEVICE COLONIZED BY AUTOLOGOUS CELLS FOR TREATMENT OF DEEP CORNEAL PATHOLOGIES SAN RAFFAELE MILANO Paganoni Giorgio Biomdica Surgical Scincs, Alssandro Biomdical Imaging, and Bionginring Bionginring, Tchnology, and Surgical Scincs BTSS Halth rlatd quality of lif in childrn with Nurofibromatosis 1: a nation wid survy projct on dtrmining factors CARLO BESTA Saltti Vronica Clinicoassistnzial Halthcar Dlivry and Mthodologis Halth Srvics Organization and Dlivry HSOD Efficacy and safty of an innovativ hrbal tratmnt on an ancint disas: th coxarthrosis Toscana FIRENZUOLI FABIO Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Arthritis, Connctiv Tissu and Skin ACTS Constitution of an infrastructur for advancd srvics in Public Halth Istituto Suprior di Sanita' CACCIA BARBARA Biomdica Halthcar Dlivry and Mthodologis Biomdical Computing and Halth Informatics BCHI In vivo molcular and imaging prdictors of dmntia in parkinsonism Toscana Voltrrani Duccio Clinicoassistnzial Brain Disordrs and Nuroscinc Nuroscinc and Nurodgnration Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 355 di 356

356 BANDO 2013 RICERCA FINALIZZATA Elnco Progtti Prsntati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazion 1 Liv. Classificazion 2 liv Involvmnt of gut ndothlial barrir modifications in cliac disas associatd hyprtransaminasmia: a modl to invstigat th gut livr axis SAN MATTEO Corazza Gino Robrto Biomdica Digstiv, Kidny and Urological Systms Gastrointstinal Mucosal Pathobiology GMPB Dvlopmnt of an intgratd risk communication wbbasd modl associatd with th consumption of food additivs IZSVE ravarotto licia Biomdica Halthcar Dlivry and Mthodologis Community Lvl Halth Promotion CLHP Projct Titl: Birth outcoms in womn with cancr: a population basd cohort study ISTITUTO TUMORI MILANO Tagliabu Giovanna Clinicoassistnzial Population Scincs and Epidmiology Epidmiology of Cancr EPIC Study of an innovativ PET with nlargd fild of viw (FOV) providd with vry high snsitivity and fficincy. Essntial for th vry arly diagnosis of cancr, INFLAMMATORY as wll as dgnrativ disass and thir mor consrvativ tratmnt. Const SAN MATTEO CORBELLA FRANCO Biomdica Bionginring Scincs and Tchnologis Instrumntation and Systms Dvlopmnt ISD Szion Bando: CO= Progtti Cofinanziati con Industria PE= Progtti Ricractor Italiano all'estro GR =Giovani Ricrcatori RF= Szion Ordinaria NET= Programmi di Rt Pagina 356 di 356