Ministero della Salute

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1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO RICERCA FINALIZZATA GRADUATORIA PROGETTI ORDINARI Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of immunosuppression within tumour microenvironment Emilia Romagna Biomedical Immunology Oncology Defective Glucose Metabolism in Polycystic Kidney Disease Defines a Novel Therapeutic Strategy: a Pre Clinical Proof of Concept Study SAN RAFFAELE Milano Biomedical Digestive, Kidney and Urological Systems Gender and geographical specific circulating microrna signatures as biomarkers of atherosclerosis, atherosclerosis progression and vascular events MONZINO Clinical Vascular and Hematology 5, Defining the cis regulatory bases for variability in inflammatory gene expression in humans: a 3 D analysis in the nuclear space I.E.O. Biomedical Genes, Genomes and Genetics 5, To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics 5,5 Pagina 1 di 231

2 "Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease." Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Immune, procoagulant and inflammatory responses in severe sepsis and septic shock MAGGIORE Biomedical Immunology Altered host virus interaction as cause of multiple sclerosis: focus on Epstein Barr virus and antiviral immune response ISS Biomedical Brain Disorders and Clinical Assessment of the macrophage role in the natural history of myeloproliferative neoplasms SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 6, Dynamics and ultrastructure of stress sensing SAN RAFFAELE Milano Biomedical Cell Biology The new biotechnologies 6, New nano systems for targeted delivery of cytokines to tumors SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 6, Role of anoctamin 1 in iodide transport and implications for the efficacy of radioiodinebased cancer therapy. Emilia Romagna Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Oncology 6, Identification of critical p53 co regulators and effectors during tumor suppression I.E.O. Biomedical Genes, Genomes and Genetics Oncology 6,5 Pagina 2 di 231

3 Determinants of Type 1 Diabetes (T1DM) clinical onset and progression in paediatric immigrant population Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive 6, GENome wide association study to Evaluate genetic risk factors for cerebral sinusvenous thrombosis (GENESIS Study) MAGGIORE Biomedical Genes, Genomes and Genetics 6, Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA Biomedical Brain Disorders and Clinical An integrated genomic, transcriptomic and epigenomic approach in multiplex multiple sclerosis families. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology Translational genetics of hereditary spinocerebellar degenerations: highthroughput exome sequencing and model organisms for the identification and characterization of novel disease genes CARLO BESTA Biomedical Genes, Genomes and Genetics Dysregulated RNA metabolism in multiple myeloma SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology N acetylcysteine in the treatment of neuropathic pain NEUROMED Biomedical Brain Disorders and Clinical 7 Pagina 3 di 231

4 Systemic Sclerosis and Chronic Graft versus Host Disease: application of novel predictive assays and generation of transgenic animal models Marche Biomedical Immunology CHANGES IN STRUCTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA Biomedical Integrative, Functional, and Cognitive 7, Generation and functional characterization of artificial lymphoid organs with mutipotent stromal progenitors SAN RAFFAELE Milano Biomedical Biology of Development and Aging Oncology 7, Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis: implications for patient oriented therapy ISS Biomedical Digestive, Kidney and Urological Systems 7, Development of a second generation PCR Based Replicon Typing system to trace and control the antimicrobial resistance spread in Enterobacteriaceae ISS Biomedical Infectious Diseases and Microbiology 7, Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress REGINA ELENA Biomedical Vascular and Hematology 7, Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Biomedical Oncology 1 Basic Translational Oncology 7,5 Pagina 4 di 231

5 Inherited arrhythmias: clinical characterization, genetic geography and experimental studies in the Calabria Region isolate. MAUGERI Biomedical Genes, Genomes and Genetics 7, Regulation of mitotic transitions I.E.O. Biomedical Cell Biology Oncology 7, ADIPOSE DERIVED MESENCHYMAL STEM CELLS AS NEW MINIMALLY INVASIVE REGENERATIVE TREATMENT TO TARGET EARLY OSTEOARTHRITIS: FROM PRE CLINICAL PROCEDURE SELECTION TO CLINICAL APPLICATION IN A RANDOMIZED DOUBLE BLINDED CONTROLLED TRIAL RIZZOLI Clinical Musculoskeletal, Oral and Skin The new biotechnologies 7, Steroid myopathy: pathogenesis and prevention MAUGERI Biomedical Musculoskeletal, Oral and Skin 7, The role of mechanobiology in establishment and progression of intima hyperplasia associated to vein coronary bypass grafts disease MONZINO Biomedical Vascular and Hematology 7, Evaluation of the potential application of bivalve shellfish as bioindicators of pollution for viral pathogens in coastal waters of southern Italy IZS Mezzogiorno Biomedical Veterinary Food safety and animal 7,5 welfare Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Biomedical Brain Disorders and Clinical 7,5 Pagina 5 di 231

6 Stress Activated Protein Kinases MLK3 and p38 as novel therapeutic targets in chemokine driven leukocyte extravasation and non resolving inflammatory processes SAN RAFFAELE Milano Biomedical Immunology 7, ETHYL EICOSAPENTAENOIC ACID ADDED TO INTERFERON ß THERAPY IN RELAPSING REMITTING MULTIPLE SCLEROSIS: A RANDOMIZED PHASE II CLINICAL TRIAL. ISS Biomedical Brain Disorders and Clinical 7, An image analysis platform for automated in situ high content and resolution analysis of tumor heterogeneity: targeting genomic, epigenetic, and functional diversity in tissues by fluorescence microscopy I.E.O. Biomedical Bioengineering and Technologies Oncology 7, Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Biomedical Cardiovascular and Respiratory From Bench to Bedside: an Integrated Approach to RASopathies ISS Biomedical Genes, Genomes and Genetics LEKTI, a multifunctional protein involved in skin desquamation and immunity: towards novel therapeutic approaches for rare and common skin diseases IDI Biomedical Musculoskeletal, Oral and Skin New Molecular Mechanisms of Leukemia Immune Evasion after Allogeneic Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 8 Pagina 6 di 231

7 Cell on chip technology as a novel tool to investigate the crosstalk between cancer and immune cells: role of the transcription factors Interferon Regulatory Factor 1 and 8 (IRF1, IRF8) in melanoma as a model system. ISS Biomedical Oncology 1 Basic Translational The new biotechnologies NEUROSTEROIDS AS DETERMINANTS OF ANTIEPILEPTIC DRUG REFRACTORINESS IN TEMPORAL LOBE EPILEPSY Emilia Romagna Biomedical Brain Disorders and Clinical New self powered devices for cochlear stimulation based on piezoelectric nanomaterials Toscana Biomedical Bioengineering and Technologies The new biotechnologies Dendritic cell based vaccine therapy in indolent non Hodgkin lymphoma patients: a phase I clinical study ISS Biomedical Oncology 2 Translational Clinical Oncology Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Hypoxia, Inflammation and redox status as determinants of malignant progression of cancer stem cells SAN RAFFAELE Pisana Roma Biomedical Oncology 1 Basic Translational Oncology Structure and biology of the Tat/Env complex and role of anti Tat/Env antibodies in HIV infection: implication for HIV/AIDS preventative vaccine development ISS Biomedical AIDS and Related Research 8 Pagina 7 di 231

8 ROLE OF THE NOVEL PRESYNAPTIC PROTEIN PRRT2 IN NEURONAL PHYSIOLOGY AND IN THE PATHOGENESIS OF PAROXYSMAL NEUROLOGICAL DISORDERS SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Vitamin D deficiency and obesity after kidney transplantation: multicenter study on gene environment interactions leading to "complex phenotypes" in a human system associated with cardiovascular events and graft rejection. Piemonte Biomedical Digestive, Kidney and Urological Systems 8, Taking a step forwards the preparedness for preventing crises: Improving the molecular detection of emerging pathogens in food. IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 8,5 welfare Tie2 monocyte mediated delivery of IFNalpha into the liver as a novel treatment for colorectal carcinoma (CRC) liver metastases. SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 8, Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Biomedical Integrative, Functional, and Cognitive 8, Genomic complexity of chronic lymphocytic leukemia (CLL): clinicobiologc implications and pharmacoeconomic evaluation at the beginning of the kinasetargeted treatment era Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology 8, Immunological Mechanisms Involved in The Pathogenesis of Primary Aldosteronism Veneto Clinical Endocrinology, Metabolism, Nutrition and Reproductive 8,5 Pagina 8 di 231

9 WHY ME? PROJECT (WM?P). INVESTIGATING WHITE MATTER CONNECTIVITY IN SCHIZOPHRENIA AT IMAGING, CELLULAR, AND TRANSPOSONE LEVELS IN MONOZYGOTIC DISCORDANT TWINS MEDEA Biomedical Brain Disorders and Clinical 8, Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation ofprevention strategies. ISS Biomedical Veterinary Food safety and animal 8,5 welfare THE ROLE OF THE BRAIN ADIPOCYTE AXIS ACTIVITY IN POTENTIATING ANTIDEPRESSANT EFFICACY ISS Biomedical Biobehavioral and Behavioral Processes 8, Does gut flora influence autoimmune responses in Multiple Sclerosis? The MAIT cell story. SANTA LUCIA Biomedical Immunology 8, CCL2/CCR2 blocking:molecular insights into a potential therapeutic strategy against HIV replication ISS Biomedical AIDS and Related Research 8, Specialized functionally connected membranes as caveolae and exosomes include molecular signature to decode melanoma progression mechanisms exploitable in clinical therapy ISS Biomedical Cell Biology Oncology 8, Electromagnetic guided in situ laser fenestration of endovascular endoprosthesis Toscana Biomedical Surgical, Biomedical Imaging, and Bioengineering 8,5 Pagina 9 di 231

10 From protein protein interaction studies new potential therapeutic targets to treat the MLL related acute lymphoblastic leukemias SDN Biomedical Oncology 1 Basic Translational Oncology 8, CARDIOriGEN MicroRNAs inducing cardiac regeneration From discovery towards clinical application Friuli Venezia Giulia Biomedical Cardiovascular and Respiratory 8, Beta adrenoceptor antagonism and biased agonism in the control of pathological neovascularization ISS Biomedical Biological Chemistry and Macromolecular Biophysics 8, Meeting senior members in the search for new associatesof the exclusive hamartromatous gene club Puglia Biomedical Digestive, Kidney and Urological Systems Oncology 8, A long ncrna point of view to FSHD muscular dystrophy pathophysiology and therapeutics. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics 8, Exploring the role of the prokineticin system in experimental autoimmune encephalomyelitis: a preclinical study towards the definition of possible novel targets of therapy for human multiple sclerosis CARLO BESTA Biomedical Immunology Induced pluripotent stem cells (ipscs) as a tool to develop neuroprotective (autologous) neural stem cell based therapy in multiple sclerosis SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 9 Pagina 10 di 231

11 A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes INFLAMMATORY AND THROMBOCCLUSIVE VASCULOPATHY: THE ROLE OF PROTEINS RELATED TO COMPLEMENT ACTIVATION. C.R.O. AVIANO Biomedical Vascular and Hematology Uncovering the molecular bases of the association of uromodulin common variants with hypertension and chronic kidney disease for the identification of novel therapeutic strategies SAN RAFFAELE Milano Biomedical Digestive, Kidney and Urological Systems Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneuronsdevelopment. SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Clostridium difficile infection in Italy: do we know the true magnitude of the problem? SPALLANZANI Clinical Infectious Diseases and Microbiology MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN ß THALASSEMIC ERYTHROPOIESIS MAGGIORE Biomedical Genes, Genomes and Genetics 9 Pagina 11 di 231

12 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Diseases of environmental 9 origin, with reference also to the workplace Expression and function of P2 receptors in human psoriatic keratinocytes. Study of their role in psoriasis pathogenesis and research of new potential therapeutic targets Emilia Romagna Biomedical Musculoskeletal, Oral and Skin Low cost cardio pulmonary monitoring system for avoidable death prevention in the hospital general ward Piemonte Biomedical Cardiovascular and Respiratory The role of early systematic best palliative care versus on request palliative care consultation during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled, multicenter trial IRST Meldola Clinical Healthcare Delivery and Methodologies Oncology GLP 1 agonists treatment vs endoscopic procedures in obesity and type II diabetes mellitus management: a randomized clinical trial. Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis SAN RAFFAELE Milano Biomedical Musculoskeletal, Oral and Skin 9 Pagina 12 di 231

13 Identification and manipulation of immunosuppressive networks in tumor microenvironment of patients undergoing immunobiological therapies. SAN RAFFAELE Milano Biomedical Immunology Oncology Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Biomedical Oncology 1 Basic Translational Oncology Dominant optic atrophy (DOA) and OPAthies in Italy (ITA DOA): minimal prevalence, genetics and phenotypes, and cell models of disease towards a therapy. Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Eco epidemiology of Mycobacterium bovis infection in Mediterranean area: a multidisciplinary approach. IZS Sicilia Biomedical Veterinary PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS ISS Biomedical Infectious Diseases and Microbiology Caffeine as a potential therapeutic option for Alzheimer's disease ISS Biomedical Brain Disorders and Clinical 9 Pagina 13 di 231

14 Human Ewing Sarcoma Family Tumor (ESFT) Revisited From Cancer Stem Cells (CSCs) to the Epigenetic Regulation: crosstalk between ncrna and DNA methylation Lombardia Biomedical Oncology 1 Basic Translational Oncology Potential role of HDL Cholesterol Efflux Capacity in the evaluation of cardiovascular risk in patients with Familial Hypercholesterolemia (FH) AOU San Martino IST Genova Biomedical Cardiovascular and Respiratory The low density lipoprotein associated protein prenylcysteine lyase: a novel player in atherosclerosis? MONZINO Biomedical Vascular and Hematology Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology Identification and validation of novel stem cell markers for the stratification of breast cancer patients. I.E.O. Biomedical Oncology 2 Translational Clinical Oncology Development of an immunotherapeutic strategy for an effective therapeutic HPV vaccine ISS Biomedical Oncology 2 Translational Clinical Oncology Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology 9 Pagina 14 di 231

15 Dietary advanced glycation end products and cardiovascular risk: animal and human studies ISS Biomedical Cardiovascular and Respiratory 9, CARPEDIEM Comorbidity And Risk Profiles Evaluation in Diabetes and heart Morbidities Toscana Clinical Healthcare Delivery and Methodologies 9, Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta, potential role in early markers development Lombardia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies 9, Analysis of the possible pathogenic roles of the inflammosome and the microbiota in Alzheimer's disease DON GNOCCHI Biomedical Brain Disorders and Clinical 9, Development of in vitro insulin producing biohybrid organ for the cure of type 1 diabetes Umbria Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 9, Involvement of ADAR1 and ADAR2 RNAediting activity on myeloid leukemia and myeloid cell differentiation: novel future therapeutic implications. OSPEDALE BAMBINO GESU' Biomedical Oncology 1 Basic Translational Oncology 9, Dissecting the role played by mechanotransduction on Cardiac Stem Cell and cardiomyocyte dysfunction. Friuli Venezia Giulia Biomedical Cardiovascular and Respiratory 9,5 Pagina 15 di 231

16 Phenotypic, functional and genomic characterization of bone fragility in children and adolescents and their relatives: exploring the susceptibility to fractures in youth for its prevention in adulthood SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics 9, Circulating endothelial progenitor cells as potential predictive and prognostic markers in metastatic colorectal cancer patients Toscana Biomedical Oncology 2 Translational Clinical Oncology 9, Developmental and genetic bases of Opitz G/BBB Syndrome towards better diagnosis and management of syndromic forms of intellectual disability BURLO GAROFALO Clinical Genes, Genomes and Genetics 9, A Nationwide Clinical Study on the Role of Functional HLA DPB1 Matching in Unrelated Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology 9, Immune therapy with T regulatory type 1 (Tr1) cells in patients with type 1 diabetes undergoing islet transplantation SAN RAFFAELE Milano Biomedical Immunology 9, The epigenetic basis of glioblastoma multiforme invasiveness and recurrence I.E.O. Biomedical Oncology 1 Basic Translational Oncology 9, Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies, and to the fibrin(ogen) integrins cell matrix interactions model sy AOU San Martino IST Genova Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 9,5 Pagina 16 di 231

17 Risk assessment of occupational and environmental exposure to benzene and other chemicals at low doses: from molecular mechanisms to biological monitoring Campania Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 9, Ghrelin as a new cardiometabolic risk biomarker: from population studies to tissue and cell biology in skeletal muscle and heart. Friuli Venezia Giulia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 9, Novel multi analyte point of care testing device for rapid diagnosis and management of sepsis and severe infection. Toscana Biomedical Interdisciplinary Molecular and Training 9, MicroRNA Signatures: Novel Biomarkers for early detection of Colorectal Cancer CASA SOLLIEVO SOFFERENZA Biomedical Oncology 2 Translational Clinical Oncology 9, Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Oncology 9, Regulatory mechanisms and therapeutic targeting of melanoma initiating cells Toscana Biomedical Oncology 1 Basic Translational Oncology 9, Phase IV clinical trial of anti viral treatment for Hepatitis C infection in compensated cirrhosis Sicilia Clinical Digestive, Kidney and Urological Systems 9, EXtending Computational Analysis of functional Images to define the total asset of Bone marrow and hematopoietic function in blood disordes (EXCALIBUR) AOU San Martino IST Genova Biomedical Bioengineering and Technologies Oncology 9,5 Pagina 17 di 231

18 Long term mechanisms of diabetes prevention and remission after bariatric surgery: study of glucose metabolism, insulin secretion and cardiovascular risk 7 years after Roux en Y Gastric bypass. Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive 9, Development Of A Novel Adoptive Cell Transfer Approach (ACT) For Cancer Immunotherapy Based On The Use Of Autologous IFN DC For The Induction Of Anti Tumor Response And Implemented By Strategies Aimed At Extending The Replicative Lifespan Of The Anti Tumo ISS Biomedical Oncology 2 Translational Clinical Oncology 9, Search for new genetic biomarkers for early diagnosis and prevention of Familial Thoracic Aortic Aneurysms and Dissections Emilia Romagna Clinical Genes, Genomes and Genetics 9, Exploiting Immunoglobulin Stereotypy as a marker of prognosis and a target for therapy in Chronic Lymphocytic Leukemia SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 9, Molecular portrait of heterogeneous lesions throughout the course of bovine tuberculosis Sardegna Biomedical Infectious Diseases and Microbiology Genomic architecture and clonal evolution of myelodysplastic syndromes and myeloproliferative neoplasms SAN MATTEO Biomedical Oncology 1 Basic Translational Oncology Engineering Commensal Bacteria for the Delivery of Therapeutic Proteins SAN RAFFAELE Milano Biomedical Bioengineering and Technologies 10 Pagina 18 di 231

19 Genetic dissection of cystic fibrosis host susceptibility to Pseudomonas aeruginosa infections using a highly genetically diverse mouse resource population, the Collaborative Cross mice SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Reverse transcriptase inhibitors in an innovative anticancer therapy ISS Biomedical Oncology 1 Basic Translational Oncology Disruption of white matter integrity in bipolar disorder: changes of diffusion tensor imaging measures as markers of the biological underpinnings of the progressive deterioration of cognition and of the cognitive control of emotions. SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Searching for early and predictive markers of individual risk for head and neck cancer Toscana Biomedical Oncology 1 Basic Translational Oncology Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice. FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Improving social dysfunction through oxytocin administration in non human infants exposed to maternal neglect early during postnatal life ISS Biomedical Biobehavioral and Behavioral Processes 10 Pagina 19 di 231

20 IMPACT OF EXPOSURE TO ESTROGEN LIKE ENDOCRINE DISRUPTING CHEMICALS(EEDC) ON PUBERTAL DEVELOPMENT AND ESTABLISHMENT OF REFERENCERANGES FOR EXPOSITION IN CHILDHOOD. OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Genetic factors influencing early plasma ribavirin cut off values in HCV therapy to reduce anemia toxicity and improve outcome. Piemonte Biomedical Infectious Diseases and Microbiology Effect of Ag nanoparticles in controlling Salmonella and Campylobacter in laying hens and clinical and food safety insights IZS Venezie Biomedical Veterinary Food safety and animal 10 welfare From the measure of guidelines adherence in oncology to the assessment of health system performance Lombardia Clinical Healthcare Delivery and Methodologies Oncology Innate immune response as a key factor aimed to optimize HCV patients therapy management SPALLANZANI Biomedical Immunology Tumor Infiltrating Lymphocytes (TIL) and melanoma: prognostic markers and new terapeutic targets IDI Biomedical Oncology 1 Basic Translational Oncology Targeted next generation sequencing as tool for molecular diagnosis of rare anemias Campania Biomedical Genes, Genomes and Genetics The new biotechnologies 10 Pagina 20 di 231

21 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) MONDINO Biomedical Molecular, Cellular, and Developmental Combining Unconventional T cells with Vaccination in Renal Cell Carcinoma Immunotherapy Puglia Biomedical Oncology 2 Translational Clinical Oncology modulation of HCN channels by GPR35 in chronic pain Toscana Biomedical Brain Disorders and Clinical DEVELOPMENT OF NOVEL ANTIBODY ENGINEERED GOLD NANOPARTICLES AS TARGETED DRUG DELIVERY FOR THE TREATMENT OF CHRONIC LUNG ALLOGRAFT DYSFUNCTION Veneto Biomedical Bioengineering and Technologies The new biotechnologies A NEW STRATEGY FOR THE CONTROL OF RHEUMATOID ARTHRITIS: DUAL ROLE OF THE ATYPICAL CHEMOTACTIC RECEPTOR CCRL2 AS A BIOMARKER AND THERAPEUTIC TARGET HUMANITAS Biomedical Immunology From lifestyle to mitochondrial benefits: study on a combined therapeutic approach to Huntington's disease ISS Biomedical Brain Disorders and Clinical New biomarkers for early SIRS/sepsis diagnosis in pediatric and adult patiens. Friuli Venezia Giulia Clinical Infectious Diseases and Microbiology 10 Pagina 21 di 231

22 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Food safety and animal welfare A Twist code of p53 inactivation in sarcomas: clinicopathological and therapeutic implications C.R.O. AVIANO Clinical Oncology 1 Basic Translational Oncology NEW ALLOCATION CRITERIA FOR LIVER TRANSPLANTATION IN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA BASED ON TRANSPLANT BENEFIT PRINCIPLES: A MULTICENTER, PROSPECTIVE STUDY. Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology Innovative diagnostic approach for hereditary cardiomyopathies MULTIMEDICA Clinical Genes, Genomes and Genetics MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII FROM DOMESTIC RUMINANTS AND WILDLIFE SPECIES BY MLVA AND NGS TECHNIQUES IZS Mezzogiorno Biomedical Infectious Diseases and Microbiology The new biotechnologies Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replicationstress response and its potential for early diagnosis and target therapy of cancer ISS Biomedical Oncology 1 Basic Translational Oncology Prospective Characterization of Circulating Tumor Cells in Patients with Hormone Receptor Positive Metastatic Breast Cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology 10 Pagina 22 di 231

23 IDENTIFICATION OF EPILEPTOGENIC NETWORKS IN SURGICAL EPILEPSIES BY A NON INVASIVE MULTIMODAL APPROACH CARLO BESTA Clinical Brain Disorders and Clinical Epithelial ovarian cancer: affecting tumor growth by targeting aberrant metabolism. IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology The extracellular matrix protein EMILIN1 as a novel structural and functional determinant of lymphangiogenesis and lymphedema C.R.O. AVIANO Biomedical Vascular and Hematology Oncology Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in Italy, Piemonte Clinical Healthcare Delivery and Methodologies Effects of Tumor associated Fibroblast and hypoxia on the availability of efficient NK cells within the tumor core: characterization of molecular targets for therapy in melanoma and colon cancer. AOU San Martino IST Genova Biomedical Immunology Oncology In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disruptingchemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Non invasive assessment of liver steatosis and fibrosis in pediatric patients SAN MATTEO Clinical Digestive, Kidney and Urological Systems 10 Pagina 23 di 231

24 MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Biomedical Cardiovascular and Respiratory HPV positive oropharyngeal cancer: characterization of immunological and viral profiles, and their role in the response to treatment SAN MATTEO Clinical Oncology 2 Translational Clinical Oncology Breast cancer with low risk of local recurrence: 3D Conformal Accelerated and Hypofractionated Partial Breast Irradiation vs. standard whole breast radiotherapy after conservative surgery Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology The complement and coagulation systems as therapeutic targets in subarachnoid hemorrhage: studies in patients and in experimental models. MAGGIORE Biomedical Brain Disorders and Clinical RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Comparative analysis of genomic and epigenomic alterations induced by leukemogenic AML1 fusion proteins I.E.O. Biomedical Oncology 1 Basic Translational Oncology Genetic markers in elderly to estimate the risk for vascular diseases by using the peripheral arterial disease model. Sicilia Biomedical Genes, Genomes and Genetics 10,25 Pagina 24 di 231

25 A phase II, randomised, placebo controlled trial of neuroprotection with Raltegravir in Secondary Progressive Multiple Sclerosis ISS Biomedical Brain Disorders and Clinical 10, Implementation of Chronic Care Model, using Tele care and Home care, in patients with multiple comorbidities: evaluation of the cost effectiveness and quality of life Toscana Clinical Healthcare Delivery and Methodologies 10, A multi site international RCT comparing regional and general anesthesia in infants for effects on neurodevelopmental outcome at five year of age: The GAS Trial. GASLINI Clinical Brain Disorders and Clinical 10, Muscle imaging in neuromuscular disorders: conventional, high and ultrahigh field imaging studies for coming into a focus STELLA MARIS Biomedical Bioengineering and Technologies The new biotechnologies 10, The molecular basis of cognitive impairment in Williams Beuren Syndrome: a cell reprogramming based approach CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics 10, Naturally occurring and re programed cancer stem cells in ovarian carcinoma: functional role and clinical implications. I.E.O. Biomedical Oncology 1 Basic Translational Oncology 10, Autonomic cardiovascular evaluation in low respiratory tract infections MAGGIORE Biomedical Cardiovascular and Respiratory 10, Assessing colorectal cancer risk: are DNA viruses and genetic damage in circulating cells valuable biomarkers? Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology 10,5 Pagina 25 di 231

26 Genomic approach for motor neuron diseases SAN RAFFAELE Milano Clinical Brain Disorders and Clinical 10, TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI Biomedical Oncology 2 Translational Clinical Oncology 10, Paratuberculosis in sheep and goats herds in Calabria and human exposure to Mycobacterium avium subspecies paratuberculosis (MAP) trough dairy products IZS Mezzogiorno Biomedical Veterinary Food safety and animal 10,5 welfare Surveillance of the circulation of rotaviruses in the infantile population of Sicily following the introduction of rotavirus vaccination Sicilia Biomedical Infectious Diseases and Microbiology 10, Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterized by selective alteration of serotonergic neuron autoinhibition. Toscana Biomedical Brain Disorders and Clinical 10, Project Title: Endoscopic Screening and oncologic appropriate removal of Early colorectal lesions. ENDOSCREEN Piemonte Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 10, Studying the tumor microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma:the role of Mesenchymal stem cells C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 10,5 Pagina 26 di 231

27 High throughput mutation profiling of Sézary Syndrome: implications for pathogenesis, classification, and potential therapeutic developments. IDI Biomedical Oncology 1 Basic Translational Oncology 10, METABOHEARTFAIL GRAPE mirnas IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN 7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON ISCHEMIC CHRONIC HEART FAILURE Toscana Biomedical Cardiovascular and Respiratory 10, Brain Mechanisms of Chronic Subjective Dizziness SANTA LUCIA Biomedical Integrative, Functional, and Cognitive 10, TRIMming away HIV 1. infection Role of TRIM proteins in establishement and maintenance of HIV 1 latency SAN RAFFAELE Milano Biomedical AIDS and Related Research 10, GISSI Outliers The CAPIRE (Coronary Atherosclerosis in outlier subjects: Protective and Individual Risk factor Evaluation) study The Life Style sub study MAUGERI Biomedical Risk, Prevention and Health Behavior 10, Exploiting neural stem cell targeted mouse models for improving the understanding of the pathogenetic mechanisms underlying Tuberous Sclerosis Complex and developing novel therapeutic approaches. SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 10, Cell senescence and age dependent decrease in heart function: role of HMGB1 protein IDI Biomedical Biology of Development and Aging 10,5 Pagina 27 di 231

28 Understanding Pancreatic Acinar Cell Carcinoma for better understanding Pancreatic Ductal Carcinoma SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 10, Development of a service interface method ( WebService) beetween family care physicians operating in a primary care setting and nephrologists, for the prevention, diagnosis and treatment of kidney damage in patients with type II diabetes mellitus. Toscana Clinical Digestive, Kidney and Urological Systems 10, Containment of a region wide outbreak of Carbapenem resistant Klebsiella pneumoniae in seven lombardian hospital: molecular characterization, epidemiology and outcome. Lombardia Clinical Infectious Diseases and Microbiology 10, Dynamics of epigenetic landscape during phase specific colorectal cancer reprogramming of stem cells and tissues in a murine stress related carcinogenesis model and human tumor biopsies. CASA SOLLIEVO SOFFERENZA Biomedical Oncology 1 Basic Translational Oncology 10, MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology 10, Genetic manipulation of embryonic stem cells and induced pluripotent stem cells (ES and ips) for endorsing cardiac fate toward beating cardiomyocytes: novel strategies for cardiac regeneration in myocardial infarction. NEUROMED Biomedical Cardiovascular and Respiratory 10,5 Pagina 28 di 231

29 Food safety of bivalve molluscs: Development and application of molecular tools for identification, quantification and evaluation of antibiotic resistance and virulence potential of food associated enteric and autochthonous bacterial pathogens IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 10,5 welfare MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes 10, Dissecting the genetic etiology of epileptic encephalopathies by high throughput sequencing GASLINI Biomedical Brain Disorders and Clinical 10, Heterotypic interactions in thromboinflammatory processes associated with the thrombotic vascular occlusion in sepsis:the role of vitamin K dependent protein C SAN RAFFAELE Milano Biomedical Immunology 10, Pre clinical evaluation of safety and efficacy of intra arterial infusion of mesenchymal stems cells in experimental models ofneurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Biomedical Brain Disorders and Clinical 10, One or more beta amyloids? Links between amyloid composition and phenotypic heterogeneity in Alzheimer's disease: implications for diagnosis and therapy CARLO BESTA Biomedical Brain Disorders and Clinical 10,5 Pagina 29 di 231

30 Genetic variability of Mycobacterium tuberculosis and its implications for transmission dynamics, pathogenesis and immune response SPALLANZANI Clinical Infectious Diseases and Microbiology 10, PHARMACOGENOMICS OF HYPERTENSION: A NEW APPROACH FOR A PERSONALIZED MEDICINE SAN RAFFAELE Milano Clinical Digestive, Kidney and Urological Systems 10, Regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 10, From breast to brain: study of the molecular mechanisms mediating the development of brain metastasis I.E.O. Biomedical Oncology 1 Basic Translational Oncology 10, Role of mast cells in the pathogenesis of diabetic heart disease. SAN RAFFAELE Milano Biomedical Cardiovascular and Respiratory 10, Investigation on the role of iron and mitochondria in neurodegenerative disorders through the development of new human neuronal cellular systems CARLO BESTA Biomedical Brain Disorders and Clinical 10, A new predictive assay to assess the efficacy of combinatorial treatments against stem cells enriched cultures from metastatic melanoma patients PASCALE Biomedical Oncology 1 Basic Translational Oncology 10, Rethinking neuroinflammation in sporadic AD: exploring novel pathways to boost endogenous neuroprotective mechanisms ISS Biomedical Brain Disorders and Clinical 10,5 Pagina 30 di 231

31 Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches SAN MATTEO Biomedical Biological Chemistry and Macromolecular Biophysics 10, DEVELOPMENT OF AN EXOSOME BASED IN VIVO TEST TO DETECT PRIONS IN BLOOD IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 10,5 welfare Development of miniaturized assays for the timely diagnosis of rare diseases Piemonte Biomedical Musculoskeletal, Oral and Skin The new biotechnologies 10, Rescue of Transforming Growth Factorbeta 1 signaling as a new strategy for neuroprotection in Alzheimer's disease: role of antidepressant drugs OASI MARIA S.S. Biomedical Brain Disorders and Clinical 10, Unravelling the genetic basis of variable clinical expression in NF1: use of an integrated next generation sequencing platform to identify novel disease causing and modifier genes. CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Oncology 10, MITOCHONDRIA AND AUTOPHAGY IN DEGENERATIVE SYNAPSES SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 10, Evaluation of the efficacy of Rapamycin and a DPP 4 inhibitor (Vildagliptin) in improving beta cell function in type 1 diabetes of long duration, a perspective randomized study SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive 11 Pagina 31 di 231

32 Long term exposure to ambient air pollution and pregnancy outcomes in women of three large Italian longitudinal studies Lazio Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA ISS Biomedical Immunology Senescence Associated micrornas (SAmiRs) in cellular senescence and organismal aging SDN Biomedical Biology of Development and Aging Postural sway and facial mimicry as behavioral markers of covert motor symptoms in Parkinson's disease in a new differential early diagnostic protocol. SANTA LUCIA Biomedical Biobehavioral and Behavioral Processes The use of top soils improvers from municipal wastewater treatment plants, on pasture: risk assessment of the associated microbial and organic chemical contamination on grazing food producing animals, and on food safety and food security (SOIL SAFE) ISS Biomedical Veterinary Food safety and animal 11 welfare Fighting impaired blood flow and supporting skeletal muscle regeneration in diabetes and peripheral artery disease (PAD): an approach based on unacylated ghrelin (UAG) administration Piemonte Biomedical Vascular and Hematology 11 Pagina 32 di 231

33 'Septosomes': System Biology and Pathogenetic Role of Exosomes in Sepsisassociated Immune paralysis and Organ Failures Piemonte Biomedical Immunology Use of Limbal Adult Stem Cells for Osteo and Condrocyte Differentiation and Application in Bone and in Cartilage Regeneration and Tissue Engineering (ABADIR PROJECT) Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies Dissecting the pathogenesis and possible reversibility of cachexia in end stage chronic heart failure Sicilia Biomedical Musculoskeletal, Oral and Skin Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto Biomedical Genes, Genomes and Genetics Fertility preservation in gonadotoxic treatments Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Co transcriptional and post transcriptional regulation of gene expression by EWS and EWS FLI1 in the pathogenesis of Ewing's Sarcoma SANTA LUCIA Biomedical Oncology 1 Basic Translational Oncology Identification of new therapeutical targets of cancer stem cells: study of the mechanistics of mitotic spindle alignment to cortical polarity in mammary stem cell asymmetric divisions I.E.O. Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 11 Pagina 33 di 231

34 Early treatment of exercise induced pulmonary hypertension in systemic sclerosis Toscana Clinical Immunology TRAIL receptor embedding in membrane rafts could predict cancer cell susceptibility to TRAIL based molecularly targeted therapy ISS Clinical Oncology 2 Translational Clinical Oncology A translational approach to hereditary neuropathies AOU San Martino IST Genova Biomedical Molecular, Cellular, and Developmental Cord blood expanded endothelial progenitors in patients with no option critical limb ischemia. Lazio Biomedical Vascular and Hematology Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost benefit analysis. Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive Imaging the fate of stem cells in vivo by near infrared technology: a translational study for longitudinal tracking in a rodent model of Parkinsons disease AUXOLOGICO Biomedical Emerging Technologies and Training in s The new biotechnologies Treatment of therapy refractory cancer in patients affected by Swachman Diamond syndrome or related inherited diseases due to alterations of the ribosomal apparatus. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Oncology 11 Pagina 34 di 231

35 The role of CRPs and SIRTs in modulating cellular stress response after myocardial infarction. SAN RAFFAELE Pisana Roma Biomedical Cardiovascular and Respiratory Early identification of left ventricular dysfunction due to anthracyclines and target therapy: role of novel imaging techniques and microrna. PASCALE Biomedical Cardiovascular and Respiratory Oncology Clinical and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regionalnetwork and use of innovative technological devices Toscana Clinical Healthcare Delivery and Methodologies Follow up study of the relationship between telomere length and the onset of diabetic complications I.N.R.C.A. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive NETWORK DEGENERATION IN MOTOR NEURON DISEASES (MND): A STUDY OF THE STRUCTURAL AND FUNCTIONAL CONNECTOMES IN AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MND SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Investigation of genetic molecular mechanisms underlying the risk of cardiovascular events: role of rs5065 human atrial natriuretic peptide gene variant NEUROMED Biomedical Genes, Genomes and Genetics A new vaccine design to eliminate CCR5 expression and prevent HIV infection SAN RAFFAELE Milano Biomedical AIDS and Related Research 11 Pagina 35 di 231

36 Identification of Determinants of Healthy Aging in Italy (IDAGIT) CARLO BESTA Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Enhancement of NKG2D ligands induced anti tumor response in Hodgkin and non Hodgkin lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin metalloproteinase as possible therapeutic targets. SAN RAFFAELE Milano Biomedical Immunology Oncology Integrated diagnostic evaluation of PET/RM and molecular markers in the diagnosis of bone lesions SDN Clinical Oncology 2 Translational Clinical Oncology Next Generation Sequencing (NGS): from basic research to diagnostic tool for nephrotic syndrome. Puglia Biomedical Genes, Genomes and Genetics The new biotechnologies Characterization of the role of Mycobacterium avium subspecies paratuberculosis (Map) as a trigger in Type 1 Diabetes Sardegna Biomedical Infectious Diseases and Microbiology Development and evaluation of Influenza Virus Polymerase Inhibitors for combination antiviral therapy ISS Biomedical Infectious Diseases and Microbiology MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA GASLINI Biomedical Oncology 1 Basic Translational Oncology 11 Pagina 36 di 231

37 Prospective validation of predictive biomarkers in elderly patients with nonsmall cell lung cancer PASCALE Biomedical Oncology 2 Translational Clinical Oncology A randomized intervention study to assess the effect of the Mediterranean Diet on the plasma fatty acid profile. MONZINO Clinical Cardiovascular and Respiratory Modulation of the metabotropic glutamate receptor 1 as a novel strategy to treat nephrotic syndrome. MAGGIORE Biomedical Digestive, Kidney and Urological Systems Positive selection, expansion and transplantation of regulatory T cells (Tregs) to prevent cellular rejection and to induce tolerance in solid organ transplantation. Emilia Romagna Clinical Immunology The new biotechnologies Molecular pathologies and functional interactions of the CDKL5 and MECP2 genes involved in a large spectrum of neuropsichiatric diseases SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical ROLE OF THE NEUROTROPHIN BDNF AND ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS MONZINO Biomedical Vascular and Hematology Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new andnoninvasive biomarkers in colon and rectal cancer I. O. V. Clinical Oncology 2 Translational Clinical Oncology 11 Pagina 37 di 231

38 PREVENTION OF MOTHER TO CHILD TRANSMISSION OF HIV: SAFETY, EFFICACY AND ACCEPTABILITY OF THE ADMINISTRATION OF TENOFOVIR, LAMIVUDINE AND EFAVIRENZ WITHIN A LIFELONG TREATMENT STRATEGY FOR ALL PREGNANT WOMEN WITH HIV ISS Biomedical AIDS and Related Research 11, The "TRIPL A Study". A TRIal to promote PhysicaL Activity among patients in the young old age affected by Type 2 diabetes I.N.R.C.A. Clinical Risk, Prevention and Health Behavior 11, Impact of deep Transcranic Magnetic Stimulation (TMS) on satiety and weight control SAN DONATO Clinical Endocrinology, Metabolism, Nutrition and Reproductive 11, Molecular and cellular mechanisms of vestibular compensation Piemonte Biomedical Molecular, Cellular, and Developmental 11, PROMOTING MOTOR RE LEARNING IN PATIENTS WITH STROKE BY ENHANCING NON INVASIVELY ASSOCIATED CEREBELLAR CORTICAL PLASTICITY. SANTA LUCIA Clinical Brain Disorders and Clinical 11, Targeting the CCR2 and CCL2 system to modulate macrophage recruitment and polarization in amyotropic lateral sclerosis HUMANITAS Biomedical Immunology 11, Development of a therapeutic approach against HIV/AIDS combining the delivery of single chain Fv antibodies and transcription activator like effector protein. ISS Biomedical AIDS and Related Research The new biotechnologies 11,5 Pagina 38 di 231

39 Hypothyroidism and Endometrial function during Blastocyst Implantation. Lazio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 11, APPLICATIONS OF ULTRASTRUCTURAL CELL ANALYSIS IN THE FIELD OF REPRODUCTIVE TECHNOLOGIES BURLO GAROFALO Clinical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies 11, Development of a biotech system for natural compound production, by plant in vitro tissue culture, for the prevention and treatment of human dismetabolic diseases. ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 11, Sonic hedgehog signaling and cholesterol dishomeostasis at the primary cilium in Niemann Pick C disease: implications for therapy Friuli Venezia Giulia Biomedical Brain Disorders and Clinical 11, Dissecting the interplay between ERK and JNK signalling in the brain. From basic mechanisms to new therapeutic approaches against neurodenegerative disorders. SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental 11, Development of nanostructured biomimetic nerve scaffolds Piemonte Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 11, Novel mechanisms mediated by nicotinic acetylcholine receptors, and interactions with nuclear PPARalpha, in the neuropathogenesis of epilepsy: preclinical and translational studies Sardegna Biomedical Brain Disorders and Clinical 11,5 Pagina 39 di 231

40 Assessing the exposure of children and other vulnerable population groups to priority dietary contaminants ISS Biomedical Veterinary Food safety and animal 11,5 welfare Discovery of Tat mimicking compounds to fight HIV latency ISS Biomedical AIDS and Related Research 11, EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS ISS Biomedical Infectious Diseases and Microbiology 11, Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE Pisana Roma Biomedical Infectious Diseases and Microbiology 11, Characterization and rescue of impaired dopaminergic signaling in primary torsion dystonia SANTA LUCIA Biomedical Brain Disorders and Clinical 11, Tuberculosis in HIV/AIDS patients: genetic diversity and drug resistance of clinical isolates of Mycobacterium tuberculosis Toscana Biomedical AIDS and Related Research 11, Autoreactive T cell expansion under the influence of interleukin 7 in patients with type I diabetes during beta cell replacemement therapy SAN RAFFAELE Milano Biomedical Immunology 11, Role of the mir 132~212 cluster in B cell receptor signaling in chronic lymphocytic leukemia: novel targets with therapeutic potential C.R.O. AVIANO Biomedical Oncology 1 Basic Translational 11,5 Pagina 40 di 231

41 The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Emilia Romagna Biomedical Brain Disorders and Clinical 11, In vivo generation of Tregs with differential homing capabilities for dissociating the antitumor effects of clinical hematopoietic stem cell transplantation from graft versushost disease SAN RAFFAELE Milano Biomedical Immunology Oncology 11, Astrocyte TRK on demyelination SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 11, Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis Emilia Romagna Biomedical Infectious Diseases and Microbiology 11, The availability of "old" and "new" drug eluting stents in routine clinical practice: influence on the treatment choice among medical therapy vs. percutaneous coronary interventions vs. coronary by pass surgery and on 4 year clinical outcome in patients w Veneto Clinical Cardiovascular and Respiratory 11, Intraventricular injection of Peripheral Blood Stem Cells during coronary artery bypass grafting in patients with heart failure induced by previous myocardial infarction. Campania Clinical Cardiovascular and Respiratory 11,5 Pagina 41 di 231

42 SMART FOOD AND LIFESTYLE INTERVENTIONS FOR HEALTHY BRAIN AGING.Developing a comprehensive protocol to assess the preventive effects of lifestyle interventions on food habits, physical and cognitive activity and social and cultural participation on cognit CARLO BESTA Clinical Brain Disorders and Clinical 11, A multicenter prospective study on inflammatory/infectious CNS diseases in different immunological settings: a multidisciplinary approach using an online data base MONDINO Clinical Brain Disorders and Clinical 11, Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A prepreclinicalstudy. ISS Biomedical Oncology 1 Basic Translational Oncology 11, Targeting leukemia cells by CD1c restricted autoreactive T cell response SAN RAFFAELE Milano Biomedical Immunology Oncology 11, The tumor cell spheroid as a key factor in the drug resistance and dissemination of high grade ovarian serous carcinoma (seoc) C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 11, Morphofunctional visual pathways evaluation in multiple sclerosis: possible identification of neurodegenerative biomarkers BIETTI Clinical Integrative, Functional, and Cognitive 11,5 Pagina 42 di 231

43 Inflammatory mechanisms underlying cortico hippocampal hyperexcitability in Alzheimer's disease: from in vitro and in vivo murine models to patient SANTA LUCIA Biomedical Brain Disorders and Clinical 11, CDCP1 as a Therapeutic Target in Triple Negative Breast Cancer IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology 11, Improving Prognostic Accuracy in Severe Traumatic Brain Injury with Diffusion Tensor Imaging MRI Combined with Cerebral Microdialysis Measurements of Axonal Proteins MAGGIORE Biomedical Brain Disorders and Clinical 11, Analysis of the role of different isoforms of thymic stromal lymphopoietin and the microbiota in T cell activation in inflammatory conditions of the gut I.E.O. Clinical Immunology 11, Colonization and infection by extensivelydrug resistant carbapenemase producing Enterobacteriaceae: towards a better understanding of the emergence and dynamics of colonization within the complex ecosystem of the human gut microbiome, of relationships be Toscana Biomedical Infectious Diseases and Microbiology 11, Food nanomaterials exposure assessment ISS Biomedical Veterinary Food safety and animal 11,75 welfare Pagina 43 di 231

44 Identification of Biomarkers for Non Melanoma Skin Cancers in a Multicenter Cohort of Kidney Transplant Recipients: Evaluation of Ethiopatogenetic Role and Clinical Implications. Piemonte Clinical Oncology 2 Translational Clinical Oncology 11, Role of ATM kinase in cerebellum development, homeostasis and function: implications for Ataxia Telangiectasia and other cerebellar disorders SANTA LUCIA Biomedical Molecular, Cellular, and Developmental CIRCULATING CELL FREE BIOMARKERS IN THE DIAGNOSIS AND FOLLOW UP OF DIFFERENTIATED THYROID CANCER Toscana Clinical Oncology 2 Translational Clinical Oncology A multiparametric approach based on clinical, biochemical, genetic and neuroimaging data to predict cognitive impairment in Parkinson's disease CASA SOLLIEVO SOFFERENZA Biomedical Brain Disorders and Clinical Role of Neutrophil activation and NET formation in venous thromboembolic disease Veneto Biomedical Vascular and Hematology Neurophysiological approach to evaluate cerebro cerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA Clinical Brain Disorders and Clinical ANTI HPV CANCER THERAPY BY ENGINEERED EXOSOMES INCORPORATING sirnas AND mirnas ISS Biomedical Bioengineering and Technologies Oncology 12 Pagina 44 di 231

45 Development of high throughput, integrated and cost effective molecular diagnostic tests for the detection of genetic and epigenetic defects involved in human disease MAGGIORE Clinical Genes, Genomes and Genetics The new biotechnologies Discovering metabolomic signatures associated with specific gene mutations in melanoma and their role in tumor radiosensitivity and immunogenicity ISS Biomedical Oncology 1 Basic Translational Oncology Role of chronic inflammation in the pathogenesis of Philadelphia negative myeloproliferative neoplasms (MPNs): an in vitro and in vivo biomolecular and functional analysis of the stem/progenitor and megakaryocytic cell compartments Emilia Romagna Biomedical Cell Biology Oncology Cardiac natriuretic peptides, human adipocytes, hypertension and dysmetabolism: in depth in vitro analysis and clinical study in elderly patients with type 2 diabetes mellitus or chronic heart failure I.N.R.C.A. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Unravelling the interplay between Helicobacter pylori and the host. Biomarkers and diagnostic tools for evaluation of H. pylori infected patients. Toscana Biomedical Infectious Diseases and Microbiology Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis. SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies 12 Pagina 45 di 231

46 CLINICAL AND MOLECULAR STUDIES OF NEXT GENERATION IN HEREDITARY SPASTIC PARAPLEGIAS STELLA MARIS Biomedical Brain Disorders and Clinical Targeting streptococcal infections in the management of patients with psoriasis Toscana Clinical Musculoskeletal, Oral and Skin Transcritpional regulation of skeletal muscle muscle maturation and degeneration: new potential targets for therapies against muscle wasting caused by neurogenic disorders and aging. SANTA LUCIA Biomedical Musculoskeletal, Oral and Skin Targeting late recurrence after adjuvant treatment for early breast cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology White Blood Cells expression profiles as a tool for predicting Metformin Efficacyin Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana Clinical Genes, Genomes and Genetics EFFECTS OF ADALIMUMAB ON PATIENT SERUM CAPACITY TO LOAD AND DISCHARGE MACHROPHAGES WITH CHOLESTEROL Lombardia Biomedical Immunology 12 Pagina 46 di 231

47 ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS Lombardia Biomedical Oncology 2 Translational Clinical Oncology Identifying low value health care interventions for patients with neurodegenerative diseases of the Central Nervous System and Stroke to support disinvestment decisions Emilia Romagna Clinical Healthcare Delivery and Methodologies Study of the mechanisms responsible for the increased cancer risk and reduced tumour sensitivity in obese and diabetic type 2 people: role of the interleukin 6 Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology NSD1 PHD fingers as potential targets for Acute Myeloid Leukemia SAN RAFFAELE Milano Biomedical Biological Chemistry and Macromolecular Biophysics Oncology Role of IP 10 and its truncated form in the pathogenesis of tuberculosis SPALLANZANI Clinical Infectious Diseases and Microbiology Characterization of HIV related mechanisms involved in the development of Burkitt's lymphoma Emilia Romagna Biomedical AIDS and Related Research BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs). IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 12 welfare Pagina 47 di 231

48 Unravelling the genetics of Autosomal Dominant Diabetes Mellitus of the Adulthood CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Can mental training based on motor imagery speed up the rehabilitation of walking? Efficacy of a controlled procedure and neurofunctional bases of recovery in patients with total knee arthroplasty GALEAZZI Clinical Biobehavioral and Behavioral Processes DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER 2+ cancer patients Piemonte Biomedical Oncology 2 Translational Clinical Oncology A FoxO1 metabolomics signature to identify patients at risk for major cardiovascular events: studies in human subjects with diabetes and atherosclerosis Lazio Biomedical Vascular and Hematology Overcoming Anti Angiogenic Therapy Resistance: Investigation of MICAL2 as a Predictive Marker and Molecular Target in Cancer Therapy Toscana Biomedical Oncology 2 Translational Clinical Oncology Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Medication overuse headache as a form of dependence Emilia Romagna Biomedical Brain Disorders and Clinical 12 Pagina 48 di 231

49 A novel in vivo diagnostic test for Creutzfeldt Jakob disease (CJD) patients by nasal brushing ISS Biomedical Brain Disorders and Clinical Role of exosomes in pericardial fluidmediated cardiac regeneration. SAN RAFFAELE Pisana Roma Biomedical Cardiovascular and Respiratory Monitoring disease progression and phenotypic heterogeneity in hereditary ataxias: clinical, cognitive, neuroimaging, and neurophysiological study to identify early markers of cerebellar dysfunction in patients and presymptomatic carriers CARLO BESTA Clinical Brain Disorders and Clinical Role of autophagy impairment in the progression from steatohepatitis to hepatocarcinoma in Hepatitis C patients. SPALLANZANI Biomedical Infectious Diseases and Microbiology Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Clinical Population and Epidemiology Effects of action observation therapy on rehabilitation of motor deficits of the dominant right upper limb in patients with MS: a study with structural and functional MRI. SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Roles of mesopontine subthalamic nucleus projections in the control of basal ganglia functions and in Parkinson disease Lazio Biomedical Brain Disorders and Clinical 12 Pagina 49 di 231

50 Biomechanical Characterization of carotid Plaque by Innovative Ultrasound in Stroke (BioCaPS) Toscana Biomedical Surgical, Biomedical Imaging, and Bioengineering Cardiotrophin 1 as a biomarker of left ventricular dysfunction in Hypertensive Heart Disease AUXOLOGICO Biomedical Cardiovascular and Respiratory Use of RNA aptamers as a novel tool for targeting Tumor Educated Myeloid Cells to control metastatic disease I. O. V. Biomedical Oncology 1 Basic Translational Oncology Identification and validation of novel biomarkers for Multiple Sclerosis and Alzheimer's Disease SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Modeling and taming the genotoxicity of viral vector integration SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics The new biotechnologies Phase 1/2 study of valproic acid and shortcourse radiotherapy plus capecitabine as preoperative treatment in low moderate risk rectal cancer PASCALE Clinical Oncology 2 Translational Clinical Oncology Reperfusion injury after cerebral ischemia: an "in vivo" study using neuro imaging markers Toscana Clinical Brain Disorders and Clinical Toward a mitochondrial imbalance readjustment therapeutic approach to counteract remote degeneration after focal acute brain damage SANTA LUCIA Biomedical Brain Disorders and Clinical 12 Pagina 50 di 231

51 Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana Biomedical Oncology 1 Basic Translational Oncology NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA IDI Biomedical Oncology 1 Basic Translational Oncology ASIC1: a Therapeutic Target for new neuroprotective pharmacological approaches for multiple sclerosis SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Alcohol intake and abuse in workplaces: development of an integrated protocol based on screening questionnaire and new methods for biological sampling and analysis. Application in healthcare workers according to Italian legislation Emilia Romagna Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 12, Development of different technologies and alternative in vivo assays to evaluate the safety of medical devices. IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 12,25 welfare Animal and human monoamine oxidases inhibition as a new strategy against anthracyclines induced mitochondrial cardiotoxicity in cancer therapy I.E.O. Clinical Oncology 2 Translational Clinical Oncology 12, Cardiovascular risk and genetic hypercholesterolemias: improving risk assessment to optimize treatment. Sicilia Biomedical Genes, Genomes and Genetics 12,5 Pagina 51 di 231

52 Genetic and epigenetic biomarkers in myasthenia gravis Toscana Biomedical Genes, Genomes and Genetics 12, Predicting post surgery complications in patients undergoing coronary artery bypass graft or major spine surgery through the assessment of perioperative cardiovascular control indexes GALEAZZI Clinical Surgical, Biomedical Imaging, and Bioengineering 12, Standardization of cord blood CD34+ cell count in a European multicenter trial. Impact on haematopoetic stem cell transplantation for haematological malignancies. Lombardia Biomedical Vascular and Hematology Oncology 12, Epigenetic therapy for the treatment of Parkinson's disease and improvement of exercise based rehabilitation S.CAMILLO Biomedical Brain Disorders and Clinical 12, The use of classical conditioning with a telemedicine approach for anomia rehabilitation in chronic aphasia: a clinical outcome research SANTA LUCIA Clinical Brain Disorders and Clinical 12, Effects of mandibular stretching on arterial blood pressure in normal volunteers and in patients with arterial hypertension: a single blinded randomized study Toscana Clinical Cardiovascular and Respiratory 12,5 Pagina 52 di 231

53 ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology 12, Gut Bacteria (microbiota) in HepAtic EncephaLopathy and Possible Utility of its Modulation (the GOAL study) DE BELLIS Clinical Infectious Diseases and Microbiology 12, Hyperthermic intra peritoneal chemotherapy (HIPEC) in Ovarian cancer recurrence: a Randomized multicentric trial on Survival Evaluation[HORSE trial] Umbria Clinical Oncology 2 Translational Clinical Oncology 12, IDENTIFICATION OF AN AUTOIMMUNE AETIOLOGY, AS DETERMINED BY SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS, IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical 12, INHIBITION OF DRUGGABLE GENE ABERRATIONS IN ER POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology 12,5 Pagina 53 di 231

54 The role of epigenetic in thyroid cancer progression and resistance to radio iodine therapy. Focus on multiple promoter methylation of thyroid specific genes (TSH R, NIS, SLC26A4, SLC5A8), and non thyroid specific BRAF associated genes (TIMP3, DAPK, RAR B REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology 12, Effects pf pre surgical cognitive rehbilitation on memory outcome after temporal lobe epilepsy surgery CARLO BESTA Clinical Brain Disorders and Clinical 12, Novel high troughoutput approaches for minimal residual disease (MRD) detection in mantle cell lymphoma (MCL) Provincia autonoma Bolzano Clinical Oncology 2 Translational Clinical Oncology 12, The role of breath fingerprints in differential diagnosis and treatment response of lower respiratory tract infections of bacterial origin Sicilia Clinical Bioengineering and Technologies The new biotechnologies 12, mirnas in lung tumorigenesis: expression signatures of serum circulating mirnas in lung cancer patients and their functional analysis SDN Biomedical Oncology 2 Translational Clinical Oncology 12, Lung cancer cell cultures from mediastinal node metastasis to develop target therapies. Lazio Clinical Oncology 1 Basic Translational Oncology 12, Molecular mechanisms of cystic fibrosis inflammation: Identification of novel potential biomarkers and therapeutic targets. Abruzzo Biomedical Cardiovascular and Respiratory 12,5 Pagina 54 di 231

55 Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO Biomedical Oncology 2 Translational Clinical Oncology 12, Soluble urokinase plasminogen activator receptor sustains immune activation in HIV+ individuals. SAN RAFFAELE Milano Biomedical AIDS and Related Research 12, Evaluation of the effect of testosterone replacement therapy (TRT) on prostatic gland in hypogonadal patients affected by benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS) Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive 12, NEXT GENERATION SEQUENCING OF GLIOBLASTOMA IMMUNOEDITING AFTER DENDRITIC CELL IMMUNOTHERAPY CARLO BESTA Biomedical Oncology 2 Translational Clinical The new biotechnologies 12, Synthesis and characterization of peptidepeptidomimetics with antagonistic activity against thrombopoietin (TPO) for the treatment of severe sepsis and septic shock: pre clinical studies. Piemonte Biomedical Infectious Diseases and Microbiology The new biotechnologies 12, PINOCCHIO: computer aided Planning and monitoring biological bone reconstructions in CHIldren Oncology. RIZZOLI Biomedical Surgical, Biomedical Imaging, and Bioengineering Oncology 12, Psychological implications in robotic rehabilitation for sub acute stroke patients Veneto Clinical Integrative, Functional, and Cognitive 12, Mechanisms of fluoropyrimidine toxicities in the perspective of personalized medicine. ARCISPEDALE Reggio Emilia Clinical Oncology 2 Translational Clinical Oncology 12,5 Pagina 55 di 231

56 A multidisciplinary approach to Early Onset Dementia ISS Biomedical Brain Disorders and Clinical 12, AVIAN BOTULISM IN LAZIO REGION: DEVELOPMENT OF A FIELD MODEL TO UNDERSTAND THE PATHOGENESIS OF AN EMEGERGING DISEASE IZS Lazio e della Toscana Biomedical Veterinary Food safety and animal 12,5 welfare The Impact of Prenatal Immune Deregulations on Synaptopathies: the case of maternal cytomegalovirus infection. HUMANITAS Biomedical Brain Disorders and Clinical 12, unraveling the pathogenesis of autoinflammatory syndromes: from improved molecular diagnosis to the identification of novel therapeutic targets BURLO GAROFALO Clinical Immunology 12, Endothelial cell alterations in metabolic syndrome, obesity and diabetes: Gender, molecular and cellular mechanisms in prevention of cardiovascular risk. MULTIMEDICA Biomedical Vascular and Hematology 12, The emerging role of micrornas in autism spectrum disorders OASI MARIA S.S. Biomedical Genes, Genomes and Genetics 12, Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severegrampositive infections Toscana Clinical Healthcare Delivery and Methodologies 12,5 Pagina 56 di 231

57 A COMBINATION THERAPY COMPRISING A 'MEGADOSE' OF T CELL DEPLETED HEMATOPOIETIC STEM CELL TRANSPLANT, HIGH DOSE POST TRANSPLANT CYCLOPHOPHAMIDE AND A REDUCED INTENSITY CONDITIONING FOR A STABLE AND LONG TERM ENGRAFTMENT Emilia Romagna Clinical Immunology 12, Framework for Genomic Analysis and Molecular Epidemiology in foodborne bacterial pathogens (acr.: GAME food) IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 12,5 welfare Calcium sensing receptor as a predictive marker in hypertensive patients SAN RAFFAELE Milano Clinical Vascular and Hematology 12, Non coding RNAs as prognostic markers for treatment personalization of cutaneous melanoma Veneto Biomedical Oncology 2 Translational Clinical Oncology 12, OVARIAN CANCER STEM CELLS: PHENOTYPIC, GENOTYPIC AND METABOLIC CHARACTERIZATION OF A SUITABLE TARGET FOR LOCO REGIONAL THERAPIES I. O. V. Biomedical Oncology 1 Basic Translational Oncology 12, Circulating Microvesicles: a Novel Biological Marker in Crohn's Disease Lazio Biomedical Digestive, Kidney and Urological Systems 12, Manipulation of the extra uterine environment through infant massage in preterm infants: effects on brain structure and function (a RCT) STELLA MARIS Clinical Brain Disorders and Clinical 12,5 Pagina 57 di 231

58 Molecular understanding of E3 ligases involved in signaling and cancer I.E.O. Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 12, The use of nanoparticles in food technology: silver nanoparticles behaviour in complex food matrices and antibacterial resistance implications IZS Venezie Biomedical Veterinary Food safety and animal 12,5 welfare ENGINEERED EXOSOMES FOR A NEW GENERATION OF ANTI HCV VACCINES ISS Biomedical Immunology 12, A susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms of P2RX7 gene coding for purinergic P2X7 receptor for extracellular ATP, in a cohort of ALS patients. SANTA LUCIA Biomedical Brain Disorders and Clinical 12, Alloimmunity and infection: insight into pathogen driven alloreactivity to develop preventive strategies for late kidney graft failure GASLINI Clinical Digestive, Kidney and Urological Systems 12, Electro clinical features, brain networks, and gene expression in Ring20 epilepsy syndrome Lombardia Biomedical Brain Disorders and Clinical 12, Identification of inducers of skin wound repair for the treatment of non healing ulcers in diabetic patients IDI Biomedical Cardiovascular and Respiratory 12, Microglia based device as a biosensor for Amyotrophic Lateral Sclerosis pathogenesis SANTA LUCIA Biomedical Brain Disorders and Clinical 12,75 Pagina 58 di 231

59 The purinergic P2X7 receptor on human cardiac fibroblast: a new therapeutic target to control cardiac remodelling in chronic heart failure? Toscana Biomedical Cardiovascular and Respiratory Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA Biomedical Brain Disorders and Clinical Prevention of antibody mediated chronic allograft injury in a prospective longitudinal study in renal transplant patients Veneto Biomedical Immunology The new biotechnologies Pediatric Cardiomyopathy: new genetic diagnostic approach by next generation sequencing (NGS) and its relation to therapeutic efficacy SDN Biomedical Genes, Genomes and Genetics A preclinical translational study for pharmacological inhibition of G protein Receptor Kinase 2 for the treatment of cardiac dysfunction: A metabolic approach. Campania Biomedical Cardiovascular and Respiratory GALACTOSYLATED PRODRUG OF KETOROLAC WITH BETTER PHARMACOKINETIC PROPERTIES AND REDUCED TOXICITY Campania Clinical Interdisciplinary Molecular and Training The new biotechnologies A multidisciplinary investigation for the improvement of aortic endografting: from biomedical engineering concepts to clinical implementation. SAN DONATO Clinical Surgical, Biomedical Imaging, and Bioengineering 13 Pagina 59 di 231

60 The Lectin pathway as a therapeutic target in stroke Lazio Biomedical Brain Disorders and Clinical Viral micrornas: a secret weapon for host gene expression alteration in B cell lymphomas Toscana Biomedical Oncology 1 Basic Translational Oncology Standard Operating Procedures for MRbased Cortical Thickness Estimation FATEBENEFRATELLI Biomedical Brain Disorders and Clinical A genome based and functional approach to improve the diagnosis and define the molecular basis of syndromic and nonsyndromic intellectual disability Piemonte Biomedical Brain Disorders and Clinical Role of intestinal microbiota in the occurrence of systemic septic complications in patients with post traumatic spinal cord and cerebral injury. Emilia Romagna Biomedical Digestive, Kidney and Urological Systems Aphasia. Theory for Therapy. S.CAMILLO Clinical Brain Disorders and Clinical Serum myostatin and type 2 diabetes: correlation with degree of metabolic control SDN Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Advanced and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD) and other related myopathies. NEUROLESI Clinical Musculoskeletal, Oral and Skin 13 Pagina 60 di 231

61 Effectiveness of a Communication Skills Training program for oncology clinicians on patient Health Related Quality of Life: a stepped wedge, cluster randomized controlled trial Lombardia Clinical Risk, Prevention and Health Behavior Oncology A packaging RNA nanotherapeutic approach to arrest nigrostriatal dopaminergic neuronal cell death in experimental Parkinson's disease OASI MARIA S.S. Biomedical Brain Disorders and Clinical Autologous transplantation of SPIO labeled bone marrow stem cells in Critical Limb Ischemia (CLI): a preclinical study. Liguria Biomedical Vascular and Hematology Cotransplantation of pancreatic islets and engineered, third party, human umbilical cord mesenchymal stem cells as a novel approach to improve graft survival and immune tolerance in type 1 diabetes patients Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Peptides from lactoferrin as new therapeutic agents against Influenza virus infection ISS Biomedical Infectious Diseases and Microbiology Telemedicine network for diagnosis and care of congenital heart malformations Toscana Clinical Healthcare Delivery and Methodologies Dipeptidyl peptidase IV inhibitors and the complex P2X7 receptor inflammasome: in vitro and in vivo studies. Toscana Biomedical Risk, Prevention and Health Behavior 13 Pagina 61 di 231

62 Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Biomedical Cardiovascular and Respiratory Analysis of KIR genotype/phenotype and HLA supratype on NK and CD8+ T cell subpopulations in elite controller, long term non progressor and HIV 1 cronically infected subjects GASLINI Biomedical AIDS and Related Research PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER(FASD) Lazio Clinical Brain Disorders and Clinical The new biotechnologies Combinatorial treatments to target cancer stem cells and elicit DNA damage in triple negative breast cancer Toscana Biomedical Oncology 1 Basic Translational Oncology Cortical myoclonus: implementation of innovative quantitative diagnostic tests and a new therapeutic strategy based on repetitive transcranial magnetic stimulation. CARLO BESTA Clinical Brain Disorders and Clinical A biopathological investigation of Nodular Lymphocyte Predominant Hodgkin Lymphoma in pediatric and adolescents patients. C.R.O. AVIANO Biomedical Oncology 2 Translational Clinical Oncology Interferome: renaissance of the innate immune system in understanding dysregulated genes and networks in multiple sclerosis. ISS Biomedical Brain Disorders and Clinical 13 Pagina 62 di 231

63 Metal on metal hip prosthesis: Cobaltinduced neurotoxicity RIZZOLI Clinical Brain Disorders and Clinical Development and validation of a multiplex real time PCR assay for the identification and discrimination of virulent Listeria monocytogenes strains in food IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 13 welfare Characterization of the interactions occurring inside the EGFR axis macromolecular complexes expressed in pancreatic ductal adenocarcinoma Lazio Clinical Oncology 2 Translational Clinical Oncology Advanced ovarian cancer as an immunologic, endocrine and metabolic disorder. Translational research for the development of a targeted approach of advanced ovarian cancer related symptoms. Sardegna Biomedical Oncology 2 Translational Clinical Oncology Early use of extracorporeal membrane oxygenation in Cardiogenic Shock (ECMICS) Lombardia Clinical Cardiovascular and Respiratory Assessment of transplant benefit of downstaging strategies in patients with hepatocellular carcinoma exceeding Milan Criteria: a randomized study IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology NOVEL TOOLS TO STUDY AND INHIBIT MALARIA GAMETOCYTE SEQUESTRATION IN HUMAN BONE MARROW ISS Biomedical Infectious Diseases and Microbiology 13 Pagina 63 di 231

64 Metastasis at the onset: to inhibit cell cannibalism in order to hinder tumor spreading ISS Biomedical Oncology 1 Basic Translational Oncology Branched peptides as cancer theranostics Toscana Biomedical Oncology 2 Translational Clinical Oncology Modulation of mirna lung cancer risk biomarkers by low dose aspirin in former smokers Liguria Clinical Oncology 2 Translational Clinical Oncology Therapeutic potential and safety assessment of gene corrected Neural Stem/Progenitor Cells (NSPC) derived from patient specific induced Pluripotent Stem Cells (ipsc) in murine models of Lysosomal Storage Diseases (LSD). SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Laparoscopic sleeve gastrectomy versus conventional medical therapy in patients with newly diagnosed type 2 diabetes and Body Mass Index Kg/m2: a randomized clinical trial Umbria Clinical Endocrinology, Metabolism, Nutrition and Reproductive Proof of principle investigation of NAMPT inhibitors in cancer and inflammatory states Piemonte Biomedical Oncology 2 Translational Clinical Oncology Markers of refractoriness in Gilles de la Tourette syndrome: pharmachological therapies and deep brain stimulation. GALEAZZI Biomedical Brain Disorders and Clinical 13 Pagina 64 di 231

65 Non Alcoholic Fatty Liver Disease (NAFLD), vitamin D and cardiometabolic risk: a proof of concept study Lombardia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Pathophysiology of frontal cortical impairments in phenylketonuria: a translational investigation. SANTA LUCIA Biomedical Brain Disorders and Clinical Global Rare Tumor Networking and new staging/prognostic concepts in Thymic Epithelial Tumors and in Non Small Cell Lung Carcinomas metastatic to the Mediastinum: an integrated clinicopathological and molecular study REGINA ELENA Clinical Oncology 2 Translational Clinical Oncology A combined therapeutic approach to Spino Bulbar Muscle Atrophy (SBMA): from cellular models to clinical studies CARLO BESTA Biomedical Brain Disorders and Clinical 13, A needs based approach to forecast future medical specialists' requirement for the Emilia Romagna Regional (ERR) NHS Emilia Romagna Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 13, The possible role of transforming growth factor beta1 and vitamin D in regulating disease activity and brain atrophy in patients with Multiple Sclerosis. SANTA LUCIA Clinical Brain Disorders and Clinical 13, Dendritic cell engineering with IRF 1 and IRF 8 for new immunotherapy interventions ISS Biomedical Oncology 2 Translational Clinical Oncology 13,25 Pagina 65 di 231

66 Occurrence of Ostreopsis genus blooms in Tyrrhenian sea : tools to prevent human intoxication due to palytoxins contaminated seafood. ISS Biomedical Veterinary Food safety and animal 13,25 welfare Discovery of new biomarkers predictive of outcome in comatose patients resuscitated from cardiac arrest AOU San Martino IST Genova Biomedical Brain Disorders and Clinical 13, Human and swine influenza viruses: reassortment and zoonotic risks IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 13,5 welfare Molecular, Pharmacogenomic and Metabolic factors associated with Recurrence in a Randomized Trial of adjuvant therapy with Aromatase Inhibitors PASCALE Biomedical Oncology 2 Translational Clinical Oncology 13, Detection of Oxidative Base Specific Lesions in the Exon 1 of the K RAS and Other Cancer Related Genes of Patients with Newly Diagnosed Colorectal Adenocarcinoma and Colorectal Polyps Toscana Biomedical Population and Epidemiology Oncology 13, Dissection of the effects of mesenchymal stem cells on glial cells involved in neurogenesis AOU San Martino IST Genova Biomedical Brain Disorders and Clinical 13, Novel approaches to understand HIV 1 nucleotide diversity affecting viral evolution, drug resistance development, and related clinical implications SPALLANZANI Biomedical AIDS and Related Research 13,5 Pagina 66 di 231

67 Development of anti PD 1 single chain antibodies with finely balanced affinity for effective immunotherapy against HIV ISS Biomedical AIDS and Related Research 13, Role of basophils derived interleukin 4 in driving thymic stromal lymphopoietin dependent pro tumor Th2 inflammation in pancreatic cancer SAN RAFFAELE Milano Biomedical Immunology Oncology 13, Cellular and molecular mechanisms underlying the dyskinetic effects of L DOPA versus Dopamine D2 D3 agonists SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 13, Novel clinical and pathogenic insight in the interplay between genotype 1 HCV infection and type 2 diabetes. Sicilia Clinical Digestive, Kidney and Urological Systems 13, A pathology for the MET oncogene: 'cancers of unknown primary origin' (CUPs) Piemonte Biomedical Oncology 1 Basic Translational Oncology 13, A long term control of biofilms and Legionella contamination of dental unit waterline to prevent patients and occupational infections using a natural terpinen 4 ol. ISS Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 13, SECURITY STANDARDIZATION AND ADAPTING OF MODERN RADIOTHERAPY THROUGH IN VIVO DOSIMETRY Lazio Clinical Oncology 2 Translational Clinical Oncology 13,5 Pagina 67 di 231

68 Identification of new causative mechanisms underling Brugada Syndrome and advanced functional analysis in patient specific induced pluripotent stem cell models. SAN RAFFAELE Milano Biomedical Cardiovascular and Respiratory 13, Cell on Chip technology as an alternative to mouse model to evaluate allergenic potential of airborne substances and of preparations for allergen specific immunotherapy. ISS Biomedical Immunology 13, Analysis of late radiation damages in terms of neurocognitive outcome after focal radiotherapy for childhood malignant brain tumors by a correlation of absorbed dose levels and magnetic resonance diffusion tensor imaging (DTI) values IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 13, Ostreopsis cf. ovata in Mediterranean fish and shellfish products: new methods for the early identification of algal toxins, mechanism of action and human risk assessment. IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 13,5 welfare Towards an optimization of epigenetic therapy of cancer I.E.O. Biomedical Oncology 1 Basic Translational Oncology 13, Unveiling the role of c MET and ALK gene alterations as druggable targets in pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 13,5 Pagina 68 di 231

69 An integrated genomic and immunomic analysis of colon cancer to identify unique tumor antigens and parameters of underlying immune response related to disease outcome SAN RAFFAELE Milano Biomedical Immunology Oncology 13, Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention in Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia Romagna Biomedical Oncology 2 Translational Clinical Oncology 13, Glioblastoma Cancer Stem Cells: a tool for identification of new diagnostic/prognostic markers and development of innovative therapeutics CASA SOLLIEVO SOFFERENZA Biomedical Oncology 1 Basic Translational Oncology 13, Characterization of cystic fibrosis airway microbiome in patients showing a severe decline in lung function and not responding to antimicrobial therapy: a multicentre study OSPEDALE BAMBINO GESU' Biomedical Infectious Diseases and Microbiology 13, Awareness and competence in mild to moderate Alzheimer's disease patients: clinical and forensic implications. Veneto Clinical Brain Disorders and Clinical 13, Understanding the interaction between inflammatory factors profile in stroke patients to design a tailored therapeutic approach MONDINO Biomedical Brain Disorders and Clinical 13,5 Pagina 69 di 231

70 Analysis of hepatitis C virus heterogeneity in direct acting antivirals (DAAs) targeted region (non structural region 3) during anti HCV treatment: new implications for treatment strategy. SAN RAFFAELE Milano Clinical Infectious Diseases and Microbiology 13, Computer Assisted Evaluation of Fracture Risk in Tumor Spine Lesions RIZZOLI Biomedical Surgical, Biomedical Imaging, and Bioengineering Oncology 13, Role of mir 155 in FLT3 ITD in mutated acute myeloid leukemia: studies of network, signalling and silencing Sicilia Biomedical Oncology 1 Basic Translational Oncology 13, Novel Electrochemical Cancer Diagnostics I.E.O. Biomedical Bioengineering and Technologies Oncology 13, A novel truncated variant of enos as a major risk factor for type 2 diabetes SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 13, Inhibition of endocannabinoidshydrolyzing enzymes as a new therapeutic target for migraine treatment: studies in animal models and preliminary evaluation in humans MONDINO Biomedical Brain Disorders and Clinical 13, Livestock associated methicillin resistant Staphylococcus aureus (LA MRSA) as cause of human infection and colonization in an Italian Region with high density of pig farming ISS Clinical Infectious Diseases and Microbiology 13,5 Pagina 70 di 231

71 Exploiting the p53 p66shc signaling pathway to identify new molecular markers for the prevention of cancerand agerelated diseases I.E.O. Biomedical Biology of Development and Aging Oncology 13, HLA G expression and DC 10 as new risk factors for HHV6 reactivation after allo HSCT. SAN RAFFAELE Milano Biomedical Immunology 13, THE MENTAL HEALTH OF UNIVERSITY STUDENTS: AN ITALIAN WEB BASED SURVEY FATEBENEFRATELLI Clinical Risk, Prevention and Health Behavior 13, Molecular characterization of human atherosclerotic plaques: role of Calcium Calmodulin dependent kinases and of their activating receptors in vascular wall and infiltrating inflammatory cells. Campania Biomedical Cardiovascular and Respiratory 13, In vitro and in vivo testing of novel therapeutic strategies for lysosomal leukodystrophies: aptamer mediated delivery of functional enzymes and gene silencing approaches GASLINI Biomedical Molecular, Cellular, and Developmental 13, Development of a dedicated ICP MS based mir sassay to quantify circulating microrna for the improvement of acute myocardial infarction diagnosis I.N.R.C.A. Biomedical Bioengineering and Technologies 13, Predictive markers of cardiovascular diseases: role of mirnas in endothelial damage. AOU San Martino IST Genova Biomedical Vascular and Hematology 13,5 Pagina 71 di 231

72 Intestinal microbiota and chronic inflammatory disease in children. Toscana Biomedical Infectious Diseases and Microbiology 13, A NOVEL EX VIVO SYSTEM FOR MONITORING THROMBUS FORMATION UNDER FLOW BASED ON ELECTRICAL IMPEDANCE TOMOGRAPHY C.R.O. AVIANO Biomedical Vascular and Hematology The new biotechnologies 13, An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification MONZINO Biomedical Brain Disorders and Clinical 13, New Therapeutic Approaches for Tuberculosis ISS Biomedical Infectious Diseases and Microbiology 13, A randomized intervention trial in breast cancer patients to evaluate a protocol aimed to obtain dietary and physical activity sustainable and permanent modifications in breast cancer patients and its effects on weight and metabolic aspects. Toscana Biomedical Oncology 2 Translational Clinical Oncology 13, IMAGE BASED PREDICTIVE MODELLING OF TUMOUR RESPONSE AND NOMAL TISSUE COMPLICATONS IN THE RADIOTHERAPY OF PELVIC MALIGNACIES I.E.O. Clinical Oncology 2 Translational Clinical Oncology 13, Muscle toxicity of proteasome inhibitor bortezomib Veneto Biomedical Oncology 2 Translational Clinical Oncology 13,5 Pagina 72 di 231

73 Prostaglandin D2 synthase a novel pathway modulating PNS myelination SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental 13, Tailoring engineered micro nanocarriers properties to finely modulate immune responses: the allergy immunotherapy proof of concept ISS Biomedical Immunology 13, DNA damage response and metabolic alterations of obesity ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 13, Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics 13, IMPACT OF VIDEOTHORACOSCOPIC, ROBOTIC AND OPEN LOBECTOMY ON QUALITY OF LIFE AND IMMUNE RESPONSE IN LUNG CANCER PATIENTS I.E.O. Clinical Oncology 2 Translational Clinical Oncology 13, Exploring the functions of the immune system in chronic fatigue syndrome (CFS) by means of silent viral infections and cytokine pathway evaluations and proteomic approach Toscana Clinical Integrative, Functional, and Cognitive 13, Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Biomedical Bioengineering and Technologies 13,75 Pagina 73 di 231

74 Development of immunoassays for the evaluation of human exposure to Aedes mosquitoes: a novel tool for the assessment of efficacy of vector control strategies and estimation of arboviral disease risk. ISS Biomedical Infectious Diseases and Microbiology 13, Slow potentials due to glial dysfunction as biomarkers of the seizure onset zone in surgically remediable focal epilepsies CARLO BESTA Biomedical Brain Disorders and Clinical 13, Tailored screening for colorectal cancer. Modulating screening interventions on individual risk profile Piemonte Clinical Risk, Prevention and Health Behavior Oncology 13, Identification of environmental and genetic risk factors in Autism Spectrum Disorders ISS Biomedical Biobehavioral and Behavioral Processes 13, An effective vaccine to prevent mucosal HIV infection based on an HIV 1 env DNA prime gp140 trimeric protein boost immunization regimen in the presence of CCL28: proof of efficacy in cynomolgous macaques. SAN RAFFAELE Milano Biomedical AIDS and Related Research Therapy de escalation in Inflammatory Bowel Disease Identification of biomarkers to assess prognostic factors in patients with mucosal healing Sicilia Clinical Digestive, Kidney and Urological Systems Governance of diabetes management in non specialistic hospital settings Emilia Romagna Clinical Healthcare Delivery and Methodologies 14 Pagina 74 di 231

75 Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies A National Electronic Library for Oncology (anelo) REGINA ELENA Biomedical Healthcare Delivery and Methodologies Oncology Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Biomedical Infectious Diseases and Microbiology Multifunctional "hybrid" drugs for targeting skeletal metastases RIZZOLI Biomedical Oncology 2 Translational Clinical Oncology IDENTIFICATION OF NOVEL MOLECULAR MECHANISMS IN THE ETHIOPATHOGENESIS OF OVARIAN CANCER Abruzzo Biomedical Oncology 1 Basic Translational Oncology Investigating epigenetic patterns induced by different diets and food for cancer preventive health enhancement I.E.O. Biomedical Genes, Genomes and Genetics Food safety and animal 14 welfare Modulating TACE secretase activity and Neuregulin 1 type III signaling to treat inherited hypermyelinating neuropathies SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Immuno predictors of cardiovascular risk in patients with psoriatic arthritis ARCISPEDALE Reggio Emilia Clinical Immunology 14 Pagina 75 di 231

76 Role of local immune response in the development of ano genital HPV related invasive diseases Lombardia Clinical Immunology Fosl2 as a p53 antagonist in cancer development and progression C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology Circulating nucleic acids in colorectal cancer: new non invasive tools for patient risk assessment and early diagnosis in high risk individuals IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology The Hereditary Diffuse Gastric Cancer syndrome: from susceptibility genes to clinical management I.E.O. Biomedical Genes, Genomes and Genetics Oncology Composition and dynamics of cholesterolrich membrane microdomains in malaria parasite infection identification of potential targets for novel intervention strategies ISS Biomedical Infectious Diseases and Microbiology Conventional multi port laparoscopic colectomy versus single incision colectomy for cancer: comparison of short and longterm results by a randomized study Toscana Clinical Surgical, Biomedical Imaging, and Bioengineering Oncology Dissection of Pertussis Toxin B oligomer (PTB) in adjuvant and anti viral components: human and mouse preclinical platforms to the identification of dimers/monomers/minimal domains to be developed as intracellular pathogen adjuvant and anti viral molecul ISS Biomedical Immunology 14 Pagina 76 di 231

77 Do anti LRP4 antibodies play a pathological significance in amyotrophic lateral sclerosis? CARLO BESTA Biomedical Immunology ULTRAsound in ischemic Stroke (ULTRAS) study AOU San Martino IST Genova Clinical Brain Disorders and Clinical Modulation by IL 1beta of GABAA and Glutamate Receptors function in human and experimental epilepsy: a novel therapeutic approach for intractable epilepsies. SAN RAFFAELE Pisana Roma Biomedical Brain Disorders and Clinical A minimal residual disease driven approach to the patient affected by follicular lymphoma receiving R CHOP Toscana Clinical Oncology 2 Translational Clinical Oncology Neuroactive steroids in Multiple Sclerosis, correlation with immunity and neurodegeneration CARLO BESTA Biomedical Brain Disorders and Clinical Role of the mitogen activated protein kinase ERK5 in the development of hepatocellular carcinoma associated with chronic liver injury Toscana Biomedical Digestive, Kidney and Urological Systems Oncology Clinical validation of an optimized MRI protocol for early diagnosis and monitoring of progressive multifocal leukoencephalopathy SAN RAFFAELE Milano Clinical Infectious Diseases and Microbiology Exploring the mechanisms of the cardiovascular effects of urban air particulate matter in susceptible individuals. Veneto Clinical Cardiovascular and Respiratory Diseases of environmental origin, with reference also to the workplace 14 Pagina 77 di 231

78 NEW HYBRID POLYMERIC SCAFFOLD FOR OSTEOCHONDRAL ENGINEERED TREATMENT RIZZOLI Biomedical Musculoskeletal, Oral and Skin The new biotechnologies Development of cultured red blood cells with rare phenotypes for diagnostic and clinical use ISS Biomedical Vascular and Hematology The new biotechnologies HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 14 welfare Investigations on the genetic predisposition to the copper metabolism dysfunction associated with Alzheimer's disease SAN RAFFAELE Pisana Roma Biomedical Genes, Genomes and Genetics Nef protein of HIV 1 contributes in increasing susceptibility to malaria and opportunistic infections through downregulation of class B scavenger receptor CD36 expression ISS Biomedical AIDS and Related Research Inflammatory environment in patients with peritoneal carcinomatosis from gastrointestinal malignancies undergoing cytoreductive surgery and HIPEC: research of systemic and peritoneal involved factors and development of a murine model SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology Estrogenic endocrine disruptors impact on autoimmunity onset and progression: the paradigm of Systemic Lupus Erythematosus ISS Clinical Immunology 14 Pagina 78 di 231

79 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO Biomedical Molecular, Cellular, and Developmental SOCIAL INTERACTION AND RIGHT BRAIN DAMAGE IN STROKE PATIENTS AUXOLOGICO Clinical Integrative, Functional, and Cognitive Influence of diet on composition of faecal microbiota and metabolites, metabolomics, in two informative cohorts: African children eating a Western diet. Implications on obesity onset and its control (MICROBESITY) DE BELLIS Clinical Endocrinology, Metabolism, Nutrition and Reproductive alpha7 nachr status and response to donepezil in Alzheimer's disease patients SAN RAFFAELE Pisana Roma Clinical Brain Disorders and Clinical Study of the involvement of KDEL receptors in inflammatory bowel disease Abruzzo Biomedical Cell Biology A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology New role of S nitrosoglutathione reductase (GSNOR) in aging and Alzheimer disease: How epigenetics regulates S nitrosylationbased signaling and nitrosative stress. SAN RAFFAELE Pisana Roma Biomedical Biology of Development and Aging GENETICS OF ENDOTHELIAL FUNCTION IN UNDERSTANDING THE PATHOGENESIS OF LACUNAR STROKE AND SMALL VESSEL DISEASE CARLO BESTA Biomedical Brain Disorders and Clinical 14 Pagina 79 di 231

80 Association between long term exposure to air pollution and neurological and metabolic impairment in adults of two large Italian longitudinal studies Piemonte Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Research of new neuroimaging biomarkers to early identify different epilepsy phenotypes in patients with Tuberous Sclerosis Complex (TSC). OSPEDALE BAMBINO GESU' Clinical Brain Disorders and Clinical Role of Periostin in prostate and breast carcinogenesis. Integrated approaches for the identification of novel prognostic and therapeutic targets. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology Otoacoustic emissions as biomarkers of possible synergistic interaction in inducing hearing damage: an experimental study INAIL Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Molecular profiling of laser microdissected prostate tissue from prostate cancer patients and not yet patients Abruzzo Biomedical Oncology 1 Basic Translational Oncology Integrated panel of biomarkers to evaluate seafood exposure to emerging contaminants along the Ligurian coasts and associated human health risks (IBIDEM) IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 14 welfare Tissue proteome and secretome of benign and malignant parathyroid tumors: identification of molecular and biochemical biomarkers for early diagnosis of parathyroid cancer Toscana Biomedical Oncology 2 Translational Clinical Oncology 14 Pagina 80 di 231

81 Epidemiological profiles and cost patterns of cancer patients (EpiCost) ISS Biomedical Healthcare Delivery and Methodologies Oncology Prevention of haemorrhagic events by minimally invasive monitoring of anticoagulant therapy Toscana Biomedical Vascular and Hematology The role of purinome in kidney chronic allograft dysfunction: extracellular ATP as a new possible early marker and trigger of fibrosis Emilia Romagna Clinical Digestive, Kidney and Urological Systems The new biotechnologies Analysis of Arterial Stiffness in women with Systemic Lupus Erythematosus: correlations with epidemiological, clinical and laboratory parameters, with the presence of hypovitaminosis D and evaluation of the effects of Cholecalciferol supplementation. Toscana Clinical Immunology Molecular signature of the progression of hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma: exosome associated micrornas and protein profiling in experimental and clinical settings ISS Clinical Oncology 2 Translational Clinical Genetic disorders of lung vascular development in children:a new, integrated approach for early recognition and molecular diagnosis. OSPEDALE BAMBINO GESU' Biomedical Genes, Genomes and Genetics A biological prospective study in patients with metastatic pancreatic neuroendocrine tumors treated with everolimus I.E.O. Clinical Oncology 2 Translational Clinical Oncology 14 Pagina 81 di 231

82 PRECLINICAL AND CLINICAL PILOT STUDIES TO ACCESS THE SAFETY AND EFFICACY OF THE USE OF HUMAN ADIPOSE TISSUE DERIVED MESENCHYMAL STEM CELLS TO PROMOTE TOLERANCE INDUCTION AND LIVER REGENERATION Sicilia Biomedical Immunology The new biotechnologies Applied Helicobacter pylori immunoproteomic, molecular and 3D structural approaches in gastric diseases to better understand the process of tumorigenesis and diagnostic biomarker discovery in early stage Gastric cancer C.R.O. AVIANO Biomedical Infectious Diseases and Microbiology Prognostic, risk stratification potentiality and cost effectiveness analysis of a multimarker strategy in the management of children with congenital heart disease Toscana Clinical Cardiovascular and Respiratory Alternative splicing of PRK2 in Parkinson's disease Sicilia Biomedical Genes, Genomes and Genetics Testing EunetHTA Core Model for national HTA reporting on relevant techonologies AGENAS Biomedical Healthcare Delivery and Methodologies The new biotechnologies A PHASE II STUDY OF AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE Emilia Romagna Clinical Digestive, Kidney and Urological Systems The new biotechnologies 14 Pagina 82 di 231

83 Study of macro and micro vascular damage in patients chronically exposed to cigarette smoking and of the impact of this assessment on the adherence of smokers to smoking cessation programs Toscana Clinical Risk, Prevention and Health Behavior FROM TISSUES TO SERUM IN CANINE MAMMARY CANCER: AN INTEGRATED CONCEPT OF MALIGNANT TUMOR PROGRESSION IZS Umbria e delle Marche Biomedical Veterinary Oncology Peptidomimetic inhibitors of aspartyi proteinases as novel therapeutics to fight mucosal candidiasis Umbria Biomedical AIDS and Related Research EFFECTS OF NUTRACEUTICAL SPIRULINA ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENTAL DISORDERS AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY ISS Biomedical Molecular, Cellular, and Developmental Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Biomedical Brain Disorders and Clinical Mental and physical health status of workers receiving redundancy payment Piemonte Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Topical propranolol administration to preserve visual function in newborns with retinopathy of prematurity. Toscana Biomedical Cell Biology 14 Pagina 83 di 231

84 New insight in the prevention of knee osteoarthritis progression: correlation between joint biomechanics and molecular cartilage homeostasis RIZZOLI Biomedical Musculoskeletal, Oral and Skin The new biotechnologies Developmental Coordination Disorder in school age children born very preterm: validation of a screening tool and relationship with ante and peri natal events. OSPEDALE BAMBINO GESU' Clinical Biobehavioral and Behavioral Processes Multifactorial study, with metabolomic profiling and circulating tumor cell characterization, of microscopic residual disease and its evolution after surgery for early breast cancer IRST Meldola Biomedical Oncology 2 Translational Clinical Oncology DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO Clinical Emerging Technologies and Training in s 14, Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenicbrain malformation CARLO BESTA Biomedical Brain Disorders and Clinical 14, Longitudinal assessment of chemotherapyinduced impairment of cognitive function and its correlation with structural changes in the cerebral white matter of patients with non small cell lung cancer (NSCLC). AOU San Martino IST Genova Clinical Oncology 2 Translational Clinical Oncology 14,25 Pagina 84 di 231

85 Searching for genetic profiles associated with IgE variability in health care workers and bakers exposed to occupational allergens Veneto Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 14, Preclinical study in mouse models to evaluate the use of the chemokine Cxcl3 in the therapy of medulloblastoma SANTA LUCIA Biomedical Oncology 1 Basic Translational Oncology 14, STUDY ON THE ANTIDEPRESSANT ACTIVITY OF FINGOLIMOD IN EXPERIMENTAL ANIMAL MODELS AND PATIENTS WITH MULTIPLE SCLEROSIS NEUROMED Biomedical Brain Disorders and Clinical 14, Novel molecular and cellular pathophysiological mechanisms of diabetic vascular disease Abruzzo Biomedical Cardiovascular and Respiratory 14, Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications. Emilia Romagna Biomedical Cardiovascular and Respiratory 14, GENETIC PREVENTION OF LYMPHOMA DEVELOPMENT IN p53 KNOCKOUT MICE REVEALS A NOVEL MOUSE MODEL OF OSTEOSARCOMA AND HEMANGIOSARCOMA. EARLY MOLECULAR AND IMMUNOLOGICAL MECHANISMS INVOLVED IN TUMOR ONSET AND MALIGNANCY AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI Biomedical Oncology 1 Basic Translational Oncology 14,5 Pagina 85 di 231

86 Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Sicilia Clinical Infectious Diseases and Microbiology 14, Molecular and Clinical study of next generation in Autism Epilepsy Phenotype: Focus on Astrocyte Neuron interaction. STELLA MARIS Biomedical Brain Disorders and Clinical 14, A novel approach to diagnosis, allocation and treatment of HCC SAN MATTEO Clinical Surgical, Biomedical Imaging, and Bioengineering Oncology 14, Characterization of the mitochondrial oxidative defect in Spinal Muscular Atrophy. Investigation of the molecular pathways leading to mitochondrial dysfunction and their relation to Spinal Muscular Atrophy pathogenesis. MAGGIORE Biomedical Brain Disorders and Clinical 14, Serum mirnas as circulating biomarkers for the early diagnosis of ovarian cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology 14, Investigation of mechanism of tumor development and new systemic drug treatment strategies to tackle the rising burden of hepatocellular carcinoma complicating Non Alcoholic Fatty Liver Disease. Emilia Romagna Biomedical Oncology 2 Translational Clinical Oncology 14, Genotype phenotype correlation in schizophrenia: role of rare variants FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes 14,5 Pagina 86 di 231

87 COronary endothelium and systemic METabolism crosstalk in the progression of cardiac dysfunction. CO MET study Toscana Biomedical Cardiovascular and Respiratory 14, Characterization of colon cancer stem cells for the identification of new prognosticmarkers and/or targets for novel anticancer therapies Basilicata Biomedical Oncology 1 Basic Translational Oncology 14, Involvement of mutant p53 gain of function in tumor microenvironment REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology 14, Role of autophagy and its regulators in melanoma and in the differential therapeutic response to BRAF inhibitors Toscana Biomedical Oncology 1 Basic Translational Oncology 14, Treatment of early osteoarthritis by deathinducible, IL 10 expressing adipose derived stem cells: a novel, safe, anti inflammatory and regenerative approach. GALEAZZI Biomedical Musculoskeletal, Oral and Skin The new biotechnologies 14, PRE TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION SAN MATTEO Biomedical Digestive, Kidney and Urological Systems 14, ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROBIOTICS Lombardia Clinical AIDS and Related Research 14,5 Pagina 87 di 231

88 Innovative diagnostic tools for the control of patulin in the agri food chain ISS Biomedical Veterinary Food safety and animal 14,5 welfare Studies on the molecular characteristics of the Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization ISS Biomedical AIDS and Related Research 14, PTPRG as a new candidate biomarker for Chronic Myeloid Leukemia Sardegna Biomedical Oncology 1 Basic Translational Oncology 14, Cortical TRPV1 in neuroglial network: a new tool for studying neuropathic pain SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 14, High throughput technologies for uncovering new diagnostic biomarkers involved in the accelerated vascular ageing of patients with chronic kidney disease Puglia Biomedical Cardiovascular and Respiratory 14, Biomarkers and Asphyxia Piemonte Biomedical Brain Disorders and Clinical 14, Pathogenesis of hemolytic uremic syndrome associated with Shiga toxinproducingescherichia coli infections: early enrolment of patients with bloody diarrhea, application of over hydration protocols, and study of the kinetic of the toxins in blood ISS Biomedical Infectious Diseases and Microbiology 14,5 Pagina 88 di 231

89 Circulating micrornas associated to cardiac derived microparticles and their role in endothelial dysfunction: agedependence of their expression in stable angina patients and following acute myocardial infarction I.N.R.C.A. Biomedical Cardiovascular and Respiratory 14, Mucosal and Systemic immunological and genetic correlates of HIV resistance in exposed HIV seronegative individuals Lombardia Clinical AIDS and Related Research 14, Type 3 ryanodine receptor in post stroke recovery: genetic, cellular and functional study. CARLO BESTA Biomedical Molecular, Cellular, and Developmental 14, Rehabilitative Homework tool in young adults with Down syndrome to prevent cognitive decline: neuropsychological and clinical study. STELLA MARIS Clinical Brain Disorders and Clinical 14, Educational intervention to reduce sugarsweetened beverages purchase at the supermarket. A community trial. Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive 14, Adolescents and young adults with cancer in Italy (AYACI) IST.TUMORI MILANO Clinical Population and Epidemiology Oncology 14, Improving appropriateness of biopharmaceutical treatments in Multiple Sclerosis: early identification of non responders, dosage and timing redefinition, mechanism of action and neurotoxicity of an "old" and a "new" drugs. Piemonte Biomedical Brain Disorders and Clinical 14,5 Pagina 89 di 231

90 Epigenetic analyses in heart failure Piemonte Biomedical Genes, Genomes and Genetics 14, Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients withmedullary Thyroid Cancer PASCALE Clinical Oncology 2 Translational Clinical Oncology 14, Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer PASCALE Biomedical Oncology 1 Basic Translational Oncology 14, Involvement of p63 in tumor development, invasion and metastasis, and its relationship with the other members of the p53 family IDI Biomedical Cell Biology Oncology 14, Erdheim Chester disease at the crossroad between clonality and inflammation: implications for therapy SAN RAFFAELE Milano Biomedical Immunology 14, Evaluation of the antitumor response of a co treatment with LHRH analogues in women with endometrial cancer at the initial diagnosis Toscana Clinical Oncology 2 Translational Clinical Oncology 14, Role of transmembrane chemokines in neuroprotection following brain ischemia NEUROMED Biomedical Brain Disorders and Clinical 14, Employment of mesenchymal stem cells as vectors for prodrug activating enzymes in prostate cancer therapy SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 14,5 Pagina 90 di 231

91 Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 14, Melanocortin 1 receptor as a regulator of proliferation pathways in melanoma SAN GALLICANO Biomedical Oncology 1 Basic Translational Oncology 14, Identification of novel therapeutic targets to halt HCV infection: a proteomic approach. SPALLANZANI Biomedical Infectious Diseases and Microbiology 14, Regulation of kinetochore activity by the conserved cell cycle kinase Rio1 I.E.O. Biomedical Cell Biology Oncology 14, Sentinel animals to monitor asbestos pollution around the former Balangero mine Piemonte Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 14, DEVELOPMENT AND CLINICAL APPLICATION OF A NEW BETA PROBE FOR RADIOGUIDED SURGERY IN MENINGIOMA TUMOR CARLO BESTA Biomedical Surgical, Biomedical Imaging, and Bioengineering 14, Role of metabotropic glutamate receptor in absence epilepsy NEUROMED Biomedical Brain Disorders and Clinical 14, Genetic and immunological factors involved in natural resistance to lentiviral infection ISS Biomedical Immunology 14, DEVELOPMENT OF NEW DIAGNOSTIC TOOLS FOR THE DETECTION OF ONCOGENIC POLYOMAVIRUSES IN HUMAN TUMORS. Emilia Romagna Biomedical Infectious Diseases and Microbiology The new biotechnologies 14,75 Pagina 91 di 231

92 Levosimendan in high risk patients undergoing non cardiac surgery. A randomized study. SAN RAFFAELE Milano Clinical Surgical, Biomedical Imaging, and Bioengineering Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening AUXOLOGICO Clinical Healthcare Delivery and Methodologies Stimulating the left Broca's area to rehabilitate verbal communicative abilities in severe post stroke aphasia SANTA LUCIA Clinical Brain Disorders and Clinical GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS. EFFECT OF MUTATIONS OF APOB AND ANGPTL3/8 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Emilia Romagna Biomedical Cardiovascular and Respiratory Marine omega 3 fatty acids and vitamin D for QTc prolongation in people with psychosis on antipsychotic drugs. SAN MATTEO Clinical Cardiovascular and Respiratory Biomarkers in Glaucoma. BIETTI Biomedical Brain Disorders and Clinical Bisphenol A, obesity and breast cancer: epidemiological, clinical, analytical and biological approach PASCALE Biomedical Oncology 1 Basic Translational Oncology Burden of alcohol related diseases and priorities for health policy control. ISS Biomedical Population and Epidemiology Oncology 15 Pagina 92 di 231

93 Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines. Toscana Biomedical Immunology Biochemical, electrophysiological and genetic determinants of disease progression and survival in Amyotrophic Lateral Sclerosis (ALS) Sicilia Biomedical Brain Disorders and Clinical TARGETING CD99 TO TREAT EWING SARCOMA RIZZOLI Biomedical Oncology 2 Translational Clinical Oncology Acute coronary syndromes in diabetic and non diabetic patients: differences in the inflammatory, immunological, and coagulation events. Campania Biomedical Cardiovascular and Respiratory Genetics of dementia: transcriptional profiles in leukocytes for the identification of biomarkers associated to disease onset, phenotype and progression. FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes Assessment of animal welfare in extensive farms of Mediterranean Area: dairy ewes and buffaloes IZS Sardegna Biomedical Veterinary Food safety and animal 15 welfare In search of new drugs and drug targets for the diagnosis and therapy of Invasive Fungal Infections (IFIs) ISS Biomedical Infectious Diseases and Microbiology 15 Pagina 93 di 231

94 Azacitidine, Depsipeptide and IFN alpha (ADI) combined treatment of colorectal cancer (CRC): depicting the therapeutic cross talk between epigenetic and IFN signatures ISS Biomedical Oncology 2 Translational Clinical Oncology Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Telemonitoring in Pediatric Patients with Heart Failure and VAD ISS Biomedical Bioengineering and Technologies Atherosclerotic effects of chronic low dose radiation exposure assessed with an integrated clinical, cellular and experimental approach: The Interventional Cardiologist Radiation Study Lombardia Biomedical Cardiovascular and Respiratory Diseases of environmental origin, with reference also to the workplace Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO Clinical Oncology 2 Translational Clinical Oncology Meta analytic assessment of mesenchymal stem cell genomic features in soft tissue sarcomas: a link to cancer dormancy and micro metastatic spread for improved prognosis and response to the therapy assessment IST.TUMORI MILANO Biomedical Genes, Genomes and Genetics Oncology 15 Pagina 94 di 231

95 Cellular and Molecular events related to neuroprotection and modulation of endogenous neurogenesis: role of estrogens in an in vivo model of hippocampal neurodegeneration. SAN RAFFAELE Pisana Roma Biomedical Molecular, Cellular, and Developmental A diagnostic and therapeutic consensus approach to multiple sclerosis in the neurological network of Verona province Veneto Clinical Brain Disorders and Clinical Comparison of the long term efficacy of bariatric surgery and new antidiabetic (GLP 1 based) therapy on diabetes remission and cardiovascular risk profile in obese type 2 diabetic patients Campania Clinical Endocrinology, Metabolism, Nutrition and Reproductive ARIEL Air Pollution and Cardiovascular Risk Investigations: the Epigenomic Link MAGGIORE Biomedical Genes, Genomes and Genetics Molecular identification of new poor prognostic subgroups of childhood Acute Lymphoblastic Leukemia as candidate for targeted therapies Lombardia Biomedical Oncology 2 Translational Clinical Oncology The effect of metabolic surgery on the immunometabolome profile in non obese type 2 diabetic patients SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive Targeting inflammasome for seizure prevention CARLO BESTA Biomedical Brain Disorders and Clinical 15 Pagina 95 di 231

96 Cognitive dysfunction after general anesthesia in the elderly: a transient, reversible phenomenon or the harbinger of Alzheimer disease? CARLO BESTA Biomedical Brain Disorders and Clinical F AH PET/CT in the diagnosis and evaluation of tumor angiogenesis in primary brain tumors HUMANITAS Clinical Oncology 2 Translational Clinical Oncology Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections ISS Biomedical Bioengineering and Technologies THE ROLE OF THE GUT MICROBIOTA IN ALZHEIMER'S DISEASE PATHOGENESIS FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Methylene blue in hypotensive vasoplegic patients. A randomized trial. SAN RAFFAELE Milano Clinical Surgical, Biomedical Imaging, and Bioengineering A MULTICENTRE PHASE II RANDOMIZED STUDY OF FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST AND SECOND LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER 2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. REGINA ELENA Clinical Oncology 2 Translational Clinical Oncology The role of Iron in White Matter changes in Neurodegenerative Diseases (Alzheimer, Parkinson and Huntington's Diseases). Does the white matter share with the gray matter the same physiopathology (iron accumulation)? SANTA LUCIA Clinical Brain Disorders and Clinical 15 Pagina 96 di 231

97 DNA replication licensing in Plasmodia: molecular characterisation of a potential new therapeutic target for malaria treatment. ISS Biomedical Infectious Diseases and Microbiology Evaluation of rubella immunity among pregnant women and development and evaluation of a postpartum and postabortion rubella vaccination protocol in a sample of Italian hospitals ISS Biomedical Infectious Diseases and Microbiology New biomarkers to predict prognosis and tailor systemic therapy in patients with Pseudomyxoma Peritonei IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology Combined study of genomic CNVs and immunological profiles in a population of patients with Autistim Spectrum Disorders (ASD) AUXOLOGICO Biomedical Genes, Genomes and Genetics Zinc Finger Protein 423 as a candidate gene for Autism Spectrum Disorder susceptibility a comprehensive analysis in mouse mutants and autistic children. SAN RAFFAELE Milano Biomedical Biobehavioral and Behavioral Processes Upper limb impairment in Charcot Marie Tooth patients: motor strategies, impact on quality of life and cortical functional reorganization DON GNOCCHI Clinical Musculoskeletal, Oral and Skin Charcot Foot: whole genome analysis and inflammatory evaluation for the development of potential treatment strategies I.N.R.C.A. Clinical Endocrinology, Metabolism, Nutrition and Reproductive 15 Pagina 97 di 231

98 Association between environmental exposure to chemical pollutants and the development of neurodegenerative diseases: a clinical epidemiological study combinated with environmental and biomolecular observations in contaminated Terzigno area Campania Biomedical Brain Disorders and Clinical Diseases of environmental origin, with reference also to the workplace Risk of in breast cancer patients: a population based study Toscana Biomedical Population and Epidemiology Oncology Identification of genetic determinants for cetuximab induced immunogenic cell death and response to treatment I.E.O. Clinical Oncology 2 Translational Clinical Oncology INNOVATIVE TREATMENTS FOR OSTEOSARCOMA: VALIDATION OF PROTEIN KINASE INHIBITORS AS TARGETED DRUGS AND ABC TRANSPORTERS INTERACTING AGENTS RIZZOLI Biomedical Oncology 2 Translational Clinical Oncology A registry of intravenous artesunate for severe malaria in returning travelers from endemic countries: pharmacokinetic data, adverse events, and clinical outcome. NetwOrk for severe MALaria treatment NOMAL study SPALLANZANI Clinical Infectious Diseases and Microbiology 15, Behavioral and neurofunctional markers of spatial awareness deficits during multitasking: Implications for diagnosis and rehabilitation of right hemisphere stroke patients S.CAMILLO Clinical Biobehavioral and Behavioral Processes 15,25 Pagina 98 di 231

99 HIV TLR4 interaction as a novel target for intervention strategies against HIV disease ISS Biomedical AIDS and Related Research 15, Mild cognitive impairment and progression to Alzheimer's disease: association with herpes viruses infections. Emilia Romagna Clinical Brain Disorders and Clinical 15, Generation and validation of a new breast cancer prognostic signature by RNAseqbased translatome profiling. Provincia autonoma Trento Biomedical Oncology 1 Basic Translational Oncology 15, BRAIN MACHINE INTERFACE (BMI) IN PARALYSIS S.CAMILLO Clinical Biobehavioral and Behavioral Processes 15, Spinal cord modular organization in recovery and back to work management of ataxic subjects INAIL Biomedical Integrative, Functional, and Cognitive 15, Exome sequencing in Individuals with Developmental Delay/Intellectual Disability of Unknown Etiology CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics The new biotechnologies 15, Project Title: Development of a dedicated evaluation track within the Hospital and a network between the Hospital and family doctors for the identification, evaluation and management of patients with osteoporotic fractures Toscana Clinical Healthcare Delivery and Methodologies 15, Stereotactic body radiotherapy as monotherapy or boost combined with externalbeam radiotherapy for localized prostate cancer IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 15,5 Pagina 99 di 231

100 A Next Generation Sequencing approach to assess blood based transcriptomic biomarkers in Coronary Artery Disease MONZINO Clinical Cardiovascular and Respiratory 15, GENETIC AND NEUROBIOLOGICAL INFLUENCES ON RISK TAKING PROPENSITY ISS Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 15, Multimodal evaluation of stroke patient's mindbrain state during upper limb robotaided therapy SAN RAFFAELE Pisana Roma Clinical Emerging Technologies and Training in s 15, Development of a diagnostic, histopathologic and therapeutic program for the management of gastrointestinal motor disorders in Parkinson disease: proposal of a new translational collaborative approach Toscana Clinical Digestive, Kidney and Urological Systems 15, Development and validation of predictive models of toxicity after radiotherapy for prostate cancer based on large data bases from clinical trials SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 15, EGFR TK inhibitors vs Chemotherapy: Improving Treatment Selection for Non Small Cell Lung Cancer (NSCLC) Patients using VeristratTM Serum Proteomic Profile Classification and Serum Amyloid A SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology 15, Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia Clinical Healthcare Delivery and Methodologies 15,5 Pagina 100 di 231

101 Insights into epigenetic changes in hepatocellular carcinoma and rationales for their therapeutic targeting Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology 15, Innovative strategies for preventing emergence and transmission of multi drug resistantgram negative bacteria in hospitalized newborns, infants, and children OSPEDALE BAMBINO GESU' Clinical Population and Epidemiology 15, BONE AND MUSCLE IN SPINAL MUSCULAR ATROPHY: FROM BENCH TO BEDSIDE. AUXOLOGICO Biomedical Musculoskeletal, Oral and Skin 15, The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE Biomedical Oncology 1 Basic Translational Oncology 15, Structural connectivity in DYT1 and DYT6 dystonia CARLO BESTA Clinical Brain Disorders and Clinical 15, Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell permeable peptides in preclinical models. MAUGERI Biomedical Brain Disorders and Clinical 15, HIV infected pregnant women treated with HAART: registry of pharmacokinetic parameters of new and commonly used antiretrovirals; mitochondrial toxicity and apoptosis in pregnant women and uteroexposed newborn SPALLANZANI Clinical AIDS and Related Research 15,5 Pagina 101 di 231

102 PROGNOSTIC ROLE OF CARDIOPULMONARY EXERCISE STRESS TEST IN MODERATE TO SEVERE AORTIC STENOSIS SAN DONATO Clinical Cardiovascular and Respiratory 15, Increased severity of respiratory viral infections in the elderly: identification of thiols level as biomarker and therapeutic target. SAN RAFFAELE Pisana Roma Biomedical Infectious Diseases and Microbiology 15, Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in gametogenesis, fertility and gonadal carcinogenesis SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies 15, EVALUATION OF THE ACTIVITY OF A NOVEL PARTIAL AGONIST OF A1 ADENOSINERECEPTOR AS POTENTIAL THERAPEUTIC AGENT FOR DIABETES AND OBESITY Abruzzo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 15, Novel biological agents for the treatment of hormone refractory prostate cancer AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Oncology 15, Clinical and neurobiological correlates of repetitive transcranial magnetic stimulation (rtms) in Alzheimer's disease MONDINO Biomedical Brain Disorders and Clinical 15, Pathophysiologic and prognostic role of OXidative stress in acute coronary sindromes: GENder differences [OXYGEN trial] Lazio Clinical Cardiovascular and Respiratory 15,5 Pagina 102 di 231

103 Avian reservoirs as a potential source of human extraintestinal pathogenic Escherichia coli ISS Biomedical Infectious Diseases and Microbiology 15, Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? IZS Venezie Biomedical Veterinary Food safety and animal 15,5 welfare Molecular characterization of the T cell dysfunctions during HIV infection to evaluate immune restoration after HAART and plan new immunotherapeutic strategies Emilia Romagna Biomedical AIDS and Related Research 15, Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia Clinical Brain Disorders and Clinical 15, Postoperative radiotherapy to the chest wall or the breast plus draining nodes in breast cancer patients: dosimetric comparison between 3DCRT, IMRT, helical tomotherapy and TomoDirect tomotherapy. Umbria Clinical Oncology 2 Translational Clinical Oncology 15, Cerebral Amyloid Angiopathy: new markers for early diagnosis and insights in pathogenetic mechanism AUXOLOGICO Clinical Brain Disorders and Clinical 15, Impact of defective DNA repair of oxidative damage on the immune response and relevance for colorectal cancer ISS Biomedical Oncology 1 Basic Translational Oncology 15,5 Pagina 103 di 231

104 Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero"haematopoietic stem cell transplantation in haemoglobinopathies Sicilia Biomedical Vascular and Hematology The new biotechnologies 15, Glioma associated stem cells: an innovative patient based approach for prognostic, predictive and therapeutic purposes. Friuli Venezia Giulia Clinical Brain Disorders and Clinical Oncology 15, Sleep wake cycle and Sundown Syndrome in Alzheimer Disease: role of the orexinergic system and relationships with neurodegeneration biomarkers SANTA LUCIA Biomedical Brain Disorders and Clinical 15, Cross talk between innate and adaptive immunity as a target for therapeutic immune intervention in the early phases of psoriasis pathogenesis ISS Biomedical Immunology 15, Cell Stess Derived Primary Cell Transformation SDN Biomedical Oncology 1 Basic Translational Oncology 15, NEW BIOMARKERS IN WORKERS EXPOSED TO INORGANIC ARSENIC MAUGERI Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 15, Focal Cortical Dysplasia Type I and Type II: Identification of causative genes and elucidation of disease pathomechanisms Toscana Clinical Brain Disorders and Clinical 15,5 Pagina 104 di 231

105 ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCER CHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 15, New frontiers in breast imaging: contrast enhanced digital mammography. Clinical performance of contrast enhanced spectral mammography (CESM SenoBright) in presurgical evaluation of extent of malignancy in a population of women with breast cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology 15, Microglial markers of central sensitization in neuropathic pain. A translational study Veneto Biomedical Brain Disorders and Clinical 15, PAIN ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH NEURODEVELOPMENTAL OUTCOME BURLO GAROFALO Clinical Brain Disorders and Clinical 15, Role of the menstrual cycle and of sexual hormones in HIV 1 infection of human cervico vaginal tissue explants SAN RAFFAELE Milano Biomedical AIDS and Related Research 15, Molecular Biomarkers for Colorectal Liver Metastases Resectability after Chemotherapy with Cetuximab REGINA ELENA Clinical Oncology 2 Translational Clinical Oncology 15, Impact of Carotid Endarterectomy and STenting on RhEological parameters and Autonomic Modulation (ICE STREAM study). SAN RAFFAELE Milano Clinical Surgical, Biomedical Imaging, and Bioengineering 15,5 Pagina 105 di 231

106 HIGH THROUGHPUT TECNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC BIOMARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) Puglia Biomedical Digestive, Kidney and Urological Systems The new biotechnologies 15, Automated Good Manufacturing Production of Adipose derived Mesenchymal Stem Cells for clinical use: validation, characterization and biosafety. RIZZOLI Clinical Bioengineering and Technologies The new biotechnologies 15, Pharmacological resistance in pituitary tumours: insights from the study of Aryl hydrocarbon Receptor Interacting Protein (AIP) as a new mediator of somatostatin analogues Abruzzo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Oncology 15, NEW DIAGNOSTIC METHODS FOR PERSONALIZED MEDICINE: AUTOMATIC GENERATION OF CLINICAL PATHWAY TROUGHT CORRELATION BETWEEN BIOCHEMICAL SCREENING AND STRESS IMAGING Marche Biomedical Cardiovascular and Respiratory 15, Optimization of In vitro and In vivo tissue engineering of functional mammary gland and uterus for prospective translational clinical application in post oncologic reconstructive surgery. Veneto Biomedical Bioengineering and Technologies The new biotechnologies 15,75 Pagina 106 di 231

107 Innovative approaches for the treatment of Pompe disease: identification of potential therapeutic targets in patients with the common splicing mutation c T>G and pharmacological chaperoning of alpha glucosidase. Friuli Venezia Giulia Biomedical Genes, Genomes and Genetics 15, Acoustic Spectroscopy of Lung Toscana Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 15, Retinal vascular imaging and risk of target organ damage among patients with suspected hypertension in primary care Piemonte Clinical Risk, Prevention and Health Behavior 15, INTEGRATION OF GENOMIC MEDICINE: THE USE OF ADPKD AS A MODEL Emilia Romagna Biomedical Genes, Genomes and Genetics The new biotechnologies 15, Genetic polymorphisms and noninvasive scores for screening patients with progressive nonalcoholicfatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Biomedical Digestive, Kidney and Urological Systems 15, Microbiome assessment in the myocardial tissue of patients with dilated cardiomyopathy and myocarditis negative to the known cardiotropic viruses. SPALLANZANI Biomedical Infectious Diseases and Microbiology Using structural and functional MRI to assess the effects of motor rehabilitation on brain plasticity in multiple sclerosis: a double blind, randomized, controlled study DON GNOCCHI Biomedical Brain Disorders and Clinical 16 Pagina 107 di 231

108 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS Lombardia Biomedical Oncology 2 Translational Clinical Oncology Oncolytic Properties of Influenza A Viruses in Human Pancreatic Tumour Cells and Xenograft Models IZS Venezie Biomedical Oncology 2 Translational Clinical Oncology Host genetic factors and response to dendritic cells based immune treatment in HIV 1 infected patients BURLO GAROFALO Clinical AIDS and Related Research Safe production of 99mTc with a biomedical cyclotron Emilia Romagna Biomedical Bioengineering and Technologies The new biotechnologies Study of the molecular mechanisms underlying the susceptibility to neonatal group B streptococcal disease SAN MATTEO Biomedical Immunology Brain proteoglycans as disease prediction genes and therapeutic targets in Multiple Sclerosis. Puglia Biomedical Brain Disorders and Clinical Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. SAN RAFFAELE Pisana Roma Biomedical Veterinary Oncology 16 Pagina 108 di 231

109 UNRAVELING THE PROTEOSTASIS NETWORK TO ADDRESS CONFORMATIONAL DISORDERS GASLINI Biomedical Genes, Genomes and Genetics Identification of new biomarkers of colorectal cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology Can we predict the degradation of cognitive status in hearing loss subjects with mild cognitive impairment based on "fluid", neurophysiological and neuroimaging markers? SAN RAFFAELE Pisana Roma Clinical Brain Disorders and Clinical Preclinical and phase II clinical study of cisplatin, cetuximab and valproic acid in recurrent and/or metastatic squamous cell carcinoma of the head and neck PASCALE Clinical Oncology 2 Translational Clinical Oncology Chemogenomics in drug discovery for regenerative therapies of common and rare myelin diseases ISS Biomedical Brain Disorders and Clinical Pathophysiological mechanisms of fibrosis: molecular characterization in a cell based assay. CARLO BESTA Biomedical Musculoskeletal, Oral and Skin Hepatitis C virus host lipoproteins interplay: development of new antiviral strategies. SPALLANZANI Biomedical Infectious Diseases and Microbiology Characterization of the relationship of microbiota, Vitamin D, and mucins towards new colorectal cancer prevention strategies. I.E.O. Clinical Oncology 2 Translational Clinical Oncology 16 Pagina 109 di 231

110 STUDY OF CONSORTIA OF PROBIOTICS USED TO IMPROVE HUMAN HEALTH ISS Biomedical Infectious Diseases and Microbiology Food safety and animal welfare Definition of a clinical and immunological phenotype of antibody mediated rejection in heart transplant recipients: prognostic and therapeutic implications Emilia Romagna Clinical Immunology DEVELOPMENT OF A NEW NON RECOMBINANT MUCOSAL VACCINE DELIVERY SYSTEM Toscana Biomedical Immunology The new biotechnologies Detection of blood borne EMT cells and risk of metastasis in colorectal cancer patients. HUMANITAS Biomedical Oncology 2 Translational Clinical Oncology Birth outcomes in women with cancer: a population based cohort study IST.TUMORI MILANO Clinical Population and Epidemiology Oncology Phenotypes in Dyslexia with genetic alteration: sensory and neuronal deficits. STELLA MARIS Clinical Integrative, Functional, and Cognitive Macrophage Senescence in Alzheimer Disease: possible link with onset and progression of the disease. I.N.R.C.A. Biomedical Brain Disorders and Clinical Role of nanomultilayers with antiinflammatory and tracking features in human islet transplantation for the treatment of type 1 diabetes Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 16 Pagina 110 di 231

111 Selective targeting of Lyn kinase and potassium channels by nocodazole and psoralen analogs in malignant cells to define innovative strategies for therapy in B cell chronic lymphocytic leukemia Veneto Biomedical Oncology 2 Translational Clinical Oncology HCV Direct Acting Antivirals (DAA) and antiretroviral drugs in pregnant women: a comprehensive surveillance/research program on maternal and neonatal safety, treatment policies, immunovirology and pharmacokinetics. ISS Biomedical Population and Epidemiology New approach for the treatment of B cell disorders via anticd20 nanoparticles Friuli Venezia Giulia Biomedical Oncology 1 Basic Translational Oncology Ebstein virus (EBV) and Human herpesvirus 6 (HHV 6) infection in Multiple Sclerosis: a trigger for autoimmunity SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Development of theranostic agents targeting molecular pathways involved in cell migration and metastases PASCALE Biomedical Oncology 1 Basic Translational Oncology A pharmacological chaperone approach to rescue nucleophosmin mutants in acute myeloid leukemia Abruzzo Biomedical Biological Chemistry and Macromolecular Biophysics Oncology Development and application of a novel Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) functional test in leukocytes Veneto Biomedical Cardiovascular and Respiratory The new biotechnologies 16 Pagina 111 di 231

112 The role of OPG, RANK and RANKL gene SNPs (single nucleotide polymorphisms) in susceptibility to acute myocardial infarction CASA SOLLIEVO SOFFERENZA Clinical Cardiovascular and Respiratory In situ proteomics profiling of membranous glomerulonephritis Lombardia Biomedical Digestive, Kidney and Urological Systems The new biotechnologies Enabling bedside neurophysiological assessment and communication in functional Locked in syndromes after acquired brain injury SANTA LUCIA Clinical Brain Disorders and Clinical Biomechanical Modeling for Customized Surgical Planning in the Cartilage Treatment of the Patello Femoral Joint. RIZZOLI Clinical Musculoskeletal, Oral and Skin The new biotechnologies Overcome resistance of mtor inhibitor in renal clear cell carcinoma targeting autophagy: a preclinical and clinical study. Lazio Biomedical Oncology 2 Translational Clinical Oncology Role of Interleukins and LOX 1 in Niemann Pick Type C Disease Neurodegeneration: possible new therapeutic targets and biomarkers. ISS Biomedical Brain Disorders and Clinical AUDIT clinico e percorsi di miglioramento nelle cure dei pazienti con infezione nelle unità di pneumologia ad alta intensità di cura (UTIR, unità di terapia intensiva respiratoria e UMR, Unità di Monitoraggio Respiratorio) della REGIONE LOMBARDIAClinical Lombardia Clinical Infectious Diseases and Microbiology 16 Pagina 112 di 231

113 NEW STRATEGY FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY OF GLIOBLASTOMA ISS Biomedical Brain Disorders and Clinical Oncology PHOSPHATE HOMEOSTATIS AND PATHOGENESIS OF MINERAL AND CARDIOVASCULAR DISORDERS CASA SOLLIEVO SOFFERENZA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Stereo body radiotherapy: a novel software expert system based on the optimization of treatment schedules IRST Meldola Clinical Oncology 2 Translational Clinical Oncology Novel biocomposite for cranial bone regeneration in pediatric patients Lazio Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies Innovative treatment of Primary Progressive Aphasias (PPA) using transcranial direct current stimulation (tdcs) combined with language training FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Influenza vaccination of the elderly: effectiveness and determinants assessment by systematic literature review and by a historical cohort study based on 13 years of mass campaigns in Lazio and Piemonte regions Lazio Clinical Infectious Diseases and Microbiology Biological bank to identify markers of disease activity related to clinical variables and modifying drugs in multiple sclerosis Emilia Romagna Clinical Immunology 16 Pagina 113 di 231

114 Development of new disease biomarkers by laboratory applications as diagnostic and prognostic tools for Amyotrophic Lateral Sclerosis Toscana Clinical Brain Disorders and Clinical The BRCAness profile: from the molecular basis to the clinical relevance Toscana Biomedical Oncology 1 Basic Translational Oncology Preclinical evaluation of isoform specific PI3K inhibitors' effects in IPF for novel potentialtherapies of malignat mesenchymal tumors Sicilia Biomedical Oncology 2 Translational Clinical Oncology Inflammatory biomarkers in phenotyped COPD: relation to extrapulmonary manifestations and dysmetabolism. Toscana Biomedical Cardiovascular and Respiratory A mirror neurons based stimulation protocol (MNSP) to improve language and behavior in mild to moderate people with Alzheimer Disease DON GNOCCHI Clinical Brain Disorders and Clinical New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies Targeting Tenascin C to inhibit early lymph node colonization by prostate cancer stem/initiating cells and immune evasion SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 16 Pagina 114 di 231

115 Investigation of the association between NF1 gene and NF1 related genes transcriptional profile and high risk of tumor development in patients affected by Neurofibromatosis type 1. Campania Biomedical Oncology 1 Basic Translational Oncology Molecular factors predictive of heart and brain involvement in myotonic dystrophy S.CAMILLO Clinical Musculoskeletal, Oral and Skin 16, The use of biomarkers in the clinical study of multiple exposure to chemicals: new diagnostic strategies to evaluate human health risk. ISS Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 16, Circulating micrornas as biomarkers of cardiovascular inflammatory diseases HUMANITAS Clinical Cardiovascular and Respiratory 16, NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana Clinical Cardiovascular and Respiratory 16, Proof of concept for a new organizational model of care delivery: the Personalized Medicine approach to the treatment of Idiopathic Environmental Intolerance Lazio Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 16, Protocol and tools towards an investigation of low dose effects in advanced radiation therapy modalities. Piemonte Biomedical Healthcare Delivery and Methodologies Oncology 16,5 Pagina 115 di 231

116 GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO Clinical Cardiovascular and Respiratory 16, Evaluation of the prognostic role of phosphatidylinositol 3 kinase pathway mutations through analysis of peripheral blood and circulating tumor cells in metastatic breast cancer patients treated with endocrine therapy Toscana Biomedical Oncology 2 Translational Clinical Oncology 16, Implementing Active Surveillance for low risk prostate cancer patients: a populationbased cohort study in the Oncological Network of Piemonte and Valle d'aosta. The PROstate CanceR Active Surveillance study (PROCRAST). Piemonte Clinical Healthcare Delivery and Methodologies Oncology 16, THE OUTCOME OF DEPRESSION AND TYPE 2 DIABETES MELLITUS WHEN THEY ARE COMORBID: A COMPARISON BETWEEN TELEMEDICINE ASSISTED CARE AND TREATMENT AS USUAL Veneto Clinical Biobehavioral and Behavioral Processes 16, Circulating micrornas as prognostic biomarkers of arterial remodeling/restenosis after percutaneous transluminal intervention in patients with peripheral arterial disease I.N.R.C.A. Biomedical Cardiovascular and Respiratory 16, Serum and tissue mirs as biomarkers for diagnosis and prognosis of B NHL in chronically HBV or HCV infected patients ISS Biomedical Oncology 2 Translational Clinical 16,5 Pagina 116 di 231

117 GENERATION OF RED CELLS WITH RARE OR UNCOMMON BLOOD GROUP PHENOTYPES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS (hipscs) Lazio Biomedical Bioengineering and Technologies The new biotechnologies 16, Puzzle: a multiparametric approach to clinical decision making and monitoring of children admitted to pediatric cardiac intensive care for congenital heart diseases OSPEDALE BAMBINO GESU' Clinical Cardiovascular and Respiratory 16, Role of autophagy core complex in tumor onset and progression SANTA LUCIA Biomedical Cell Biology Oncology 16, Clinical markers of chilhood apraxia of speech and its neurobiological and genetic correlates STELLA MARIS Clinical Brain Disorders and Clinical 16, GENETIC INVOLVEMENT OF DESMOPLAKIN AND OTHER DESMOSOMAL PROTEINS IN DILATED CARDIOMYOPATHY SAN MATTEO Biomedical Cardiovascular and Respiratory 16, Neurorehabilitation of post stroke disorders using integrated behavioral and brain stimulation tools SANTA LUCIA Clinical Brain Disorders and Clinical 16, Dissection of the MYCN/MAX/MAD transcription factor network as a critical step to designnovel therapeutic approaches to treat pediatric neuroblastoma Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology 16, Intranasal delivery of nano modified drugs for the treatment of glioblastoma Toscana Biomedical Oncology 1 Basic Translational Oncology 16,5 Pagina 117 di 231

118 Health impact assessment and health care costs of respiratory tract infections (RTIs) in general population and hospitalized patients Sicilia Biomedical Population and Epidemiology 16, High throughput, population wide, reflex testing of GI cancer: biologic characterization, identification of individualized therapy targets and prevention of familial cases AOU San Martino IST Genova Clinical Oncology 2 Translational Clinical Oncology 16, Role of tumor microenvironment in thyroid carcinogenesis onset and progression: thyroid cells cross talk with macrophages IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology 16, Identification and characterization of genes involved in progenitor cells reprogramming into stem cells and cancer stem cells, as novel cancer therapeutic targets. I.E.O. Biomedical Oncology 1 Basic Translational Oncology 16, Unraveling the role of sodium channels in the susceptibility to neuropathic pain CARLO BESTA Biomedical Genes, Genomes and Genetics 16, A diagnostic innovative software for surgical planning in hip arthroplasty for patients with hip dysplasia to optimize functional recovery. RIZZOLI Clinical Bioengineering and Technologies The new biotechnologies 16, DEVELOPMENT OF A NEW ARTIFICIAL HEART FOR PEDIATRIC PATIENTS WITH OSPEDALE BAMBINO GESU' Clinical Cardiovascular and Respiratory 16,5 END STAGE HEART FAILURE Pagina 118 di 231

119 Ankrd2 as a novel repressor of immune and inflammatory responses through regulation of myokine expression. HUMANITAS Biomedical Musculoskeletal, Oral and Skin 16, Molecular modeling of advanced/metastatic soft tissue sarcomas to develop evidencebased therapeutic targets and circulatory biomarkers RIZZOLI Biomedical Oncology 2 Translational Clinical Oncology 16, The extracellular matrix EMILIN2 as a key molecule regulating colon carcinogenesis and as a potential prognostic marker. C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 16, Integrated analysis of somatic mutations and related altered pathways for the identification of new biomarkers and molecular targets in tumors of the lower female genital tract. PASCALE Clinical Oncology 1 Basic Translational Oncology 16, Early Retinal Neuroprotection as a Novel Tool to Achieve the Primary Prevention of Diabetic Retinopathy SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive 16, Risk of metachronous cancer in genetically predisposed colorectal patients IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 16, Diagnostic, prognostic, and monitoring markers based on muscular, neurophysiological and neuroimaging markers in dystonic patients. A pilot clinical study SDN Clinical Brain Disorders and Clinical 16,5 Pagina 119 di 231

120 A network of external quality controls for the molecular diagnosis of sporadic and hereditary cancers Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology 16, TrkAIII expression in Glioblastoma: Significance in prognosis, relationship to therapeutic response and role in pathogenesis and progression. Abruzzo Biomedical Oncology 2 Translational Clinical Oncology 16, New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI Clinical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 16, Spatially variant prescription of dose radiation from hypoxic tumor distribution assessed by VEGF expression and biological imaging: a phases I II study in non small cell lung cancer CROB Biomedical Oncology 2 Translational Clinical Oncology 16, Heart liver axis in metabolic syndrome: common damage mechanisms as an input for patient management OSPEDALE BAMBINO GESU' Biomedical Cardiovascular and Respiratory 16, Evaluation of patient preferences around the different cancer services dimensions: new evidences for improving service organisation. Piemonte Clinical Healthcare Delivery and Methodologies Oncology 16, Modulating the inflammation of cerebral death to improve the survival of graft Campania Biomedical Surgical, Biomedical Imaging, and Bioengineering 16,5 Pagina 120 di 231

121 SILK BASED BASEMENT MEMBRANE MODEL: A NEW TOOL FOR THE STUDY OF PLATELET PRODUCTION, FUNCTIONALITY AND THERAPEUTIC APPROACHES SAN MATTEO Biomedical Bioengineering and Technologies The new biotechnologies 16, Natural history of Myotonic Dystrophy type 1. Epidemiology in the Lazio region, clinical protocol standardization, and assessment of clinical and molecular endpoints in a longitudinal cohort study. SANTA LUCIA Clinical Population and Epidemiology 16, Prospective multicenter study on antibiotic prophylaxis protocol (ABP) for the prevention of Neurosurgical Surgical Site Infection (N SSIs), with taylored strategies for High Risk (HR) classes CARLO BESTA Clinical Infectious Diseases and Microbiology 16, AFTEREIGHT study: anticipated boost with intraoperative electrons (IORT) followed by short course hypofractionated whole breast radiotherapy in early breast cancer patients. I.E.O. Clinical Healthcare Delivery and Methodologies Oncology 16, THE ROLE OF CALCIUM HOMEOSTASIS IN CONGENITAL CEREBELLAR ATAXIAS : genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ATPase OSPEDALE BAMBINO GESU' Biomedical Molecular, Cellular, and Developmental 16, HIV INFECTION AND ANTIRETROVIRAL TREATMENT: EFFECTS ON BONE MARROW HEMATOPOIETIC STEM CELLS SPALLANZANI Biomedical AIDS and Related Research 16,5 Pagina 121 di 231

122 Translational approach to the cardiovascular effects of antipsychotics Piemonte Biomedical Emerging Technologies and Training in s 16, Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack IZS Mezzogiorno Biomedical Veterinary Food safety and animal 16,5 welfare Vagal nerve stimulation as a novel strategy to limit post ischemic injury and possibly to prevent the development of ischemic cardiomyopathy AUXOLOGICO Biomedical Cardiovascular and Respiratory 16, Mother to infant transmission of infectious diseases: development of clinical pathways for an appropriate/comprehensive care of pregnant women with infections and their infants. OSPEDALE BAMBINO GESU' Clinical Infectious Diseases and Microbiology 16, Innovative biological markers in type 1 diabetes SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 16, WNV endemization in Italy: implications for the national transplant program SPALLANZANI Biomedical Infectious Diseases and Microbiology 16, Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in Italian NHS. AGENAS Clinical Healthcare Delivery and Methodologies 16, Aging related platelet transcriptome variations in atherothrombosis Umbria Biomedical Biology of Development and Aging 16,5 Pagina 122 di 231

123 Effects of a controlled exercise intervention in modulating endothelial dysfunction and related humoral markers in coronary patients with type 2 diabetes DON GNOCCHI Biomedical Cardiovascular and Respiratory 16, Imaging predictors of outcome after Surgical myocardial revascularization [RESOLUTION trial] Lazio Clinical Cardiovascular and Respiratory 16, New molecular markers of pathogenetic and translational significance in tumoral and peritumoral tissue of primary liver cancer HUMANITAS Biomedical Oncology 1 Basic Translational Oncology 16, OVERWEIGHT/OBESITY/SEVERE OBESITY: TIME TRENDS AND LONGTERM BENEFITS OF WEIGHT REDUCTION ISS Biomedical Risk, Prevention and Health Behavior 16, A tool to diagnose the impairment of aphasic patients and direct rehabilitation by analysing speech errors SANTA LUCIA Clinical Integrative, Functional, and Cognitive 16, Integrated approach to investigate the effect of environmental pollution on reproductive outcomes Emilia Romagna Biomedical Genes, Genomes and Genetics Diseases of environmental 16,75 origin, with reference also to the workplace In vivo model for tissue engineering of urethral reconstruction on bio absorbable scaffold or recellularized matrixes Sicilia Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 16,75 Pagina 123 di 231

124 Early integration of palliative care with standard oncologic care in advanced nonsmall cell lung cancer. A prospective,multicenter observational study to evaluate how this approach impact on patients survival and quality of life with an additional anal Veneto Clinical Healthcare Delivery and Methodologies Oncology 16, Fostering donation: from bench to culture MAGGIORE Clinical Healthcare Delivery and Methodologies 16, HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 16, Innovative aspects in the study of acute hepatitis C, in the laboratory diagnosis and study of clinica, genetic, virological and biomolecular prognostic markers and in the optimization of therapeutic protocols Campania Biomedical Infectious Diseases and Microbiology MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology A CLINICAL AND MORPHOLOGICAL INVESTIGATION OF BOTULINUM TOXIN A TREATMENT FOR NEUROGENIC DETRUSOR OVERACTIVITY: OUTCOMES, CORRELATION BETWEEN URODYNAMIC PATTERN AND EXPRESSION OF UROTHELIUM AND SUBUROTHELIUM ION CHANNELS AND NEUROKININ RECEPTORS IN SPINA Toscana Biomedical Digestive, Kidney and Urological Systems 17 Pagina 124 di 231

125 Standardization of a SNP typing protocol for epidemiology of Listeria monocytogenes and study of the molecular evolution of an emerging Epidemic Clone. IZS Puglia e della Basilicata Biomedical Infectious Diseases and Microbiology Food safety and animal welfare Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with Difficult Diagnosis in the Italian population, with special focus on the sick worker. Implications for Disease Definition, Diagnosis and Treatment, and Workplace S IDI Biomedical Immunology Diseases of environmental 17 origin, with reference also to the workplace PERFUSION COMPUTED TOMOGRAPHY (PCT) AND VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF A) SERUM AND LIQUOR LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS NEUROMED Clinical Emerging Technologies and Training in s Oncology Instrumental and clinical validation of a new diagnostic therapeutic approach to the dysfunction of movement for rehabilitation in non specific low back pain Emilia Romagna Clinical Bioengineering and Technologies Diseases of environmental origin, with reference also to the workplace Development and validation of software tools to use radiation dose data extracted from digital medical images for radiation protection purposes I. O. V. Clinical Surgical, Biomedical Imaging, and Bioengineering Oncology Sleep disorders in neuromuscular diseases: a comprehensive clinical and polisomnographyc study regarding myotonic dystrophies type 1 and type 2 and spinal bulbar muscular atrophy (SBMA). Lazio Biomedical Brain Disorders and Clinical 17 Pagina 125 di 231

126 Clinical Impact of Image guided hypofractionated intensity modulated radiotherapy in the treatment of prostate, lung and head and neck cancers Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Definition of a "Myeloma Panel" to analyze the role played by clonal evolution in the resistance to therapy Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology A translational integrated study on prostate diseases and environmental risk factors in Sicily for primary and secondary prevention (acronym: PROSTENV) ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Risk assessment of developing atypical Hemolitic Uremic Syndrome by genetic and epigenetic investigations MAGGIORE Biomedical Genes, Genomes and Genetics IDENTIFICATION OF NEW DRUGGABLE PATHWAYS FOR PERSONALIZED TREATMENTS IN INTRAHEPATIC CHOLANGIOCARCINOMA Piemonte Biomedical Oncology 2 Translational Clinical Oncology Preclinical Development of Novel Small Androgen Receptor Modulating Molecules (SARMs) in Experimental Human Prostate Cancer Model. IRST Meldola Biomedical Oncology 2 Translational Clinical Oncology Role of Vitamin D receptor in angiogenic and DNA damage repair pathways with respect to BRCA1 status ONCOLOGICO DI BARI Biomedical Oncology 2 Translational Clinical Oncology 17 Pagina 126 di 231

127 Internet Addiction in adolescents: identification of possible neurobiological and personality markers. Toscana Biomedical Brain Disorders and Clinical Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Biomedical Brain Disorders and Clinical Assessment of Predictive Biomarkers of Outcome and Treatment Response in Primary Tumor and in Circulating Tumor Cells of Non Small Cell Lung Cancer Patients by Organization of a Clinical and Molecular Network in Sicily Sicilia Clinical Oncology 2 Translational Clinical Oncology The molecular basis of the interplay between leukotriene and purinergic systems: new therapies in vascular inflammation Lombardia Biomedical Cardiovascular and Respiratory Causes, diagnosis and treatment of unexplained neurobehavioral disorders: role of thyroid hormone cell membrane transporters and environmental contaminants. Toscana Biomedical Integrative, Functional, and Cognitive Innovative preclinical platforms for the personalized treatment in ovarian cancer Piemonte Biomedical Oncology 2 Translational Clinical Oncology 17 Pagina 127 di 231

128 Multi Step versus Single Step strategy of Transjugular Intrahepatic Portosystemic Shunt (TIPS) Endoprosthesis Placement for Prevention of Post TIPS Hepatic Encephalopathy in Cirrhotic Patients with Refractory Ascites. Emilia Romagna Clinical Digestive, Kidney and Urological Systems Traditional and innovative monitoring of dioxins and dioxin like compounds in exposed sheep: chemical and biomolecular approaches in a sentinel species. IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 17 welfare DEVELOPMENT OF 3D IN VITRO TUMOUR/MSC COCULTURE MODEL AND IN VIVO IMAGING LUMINESCENT PROTOCOL TO REFINE AND REDUCE THE USE OF ANIMAL IN ONCOLOGICAL STUDIES. (DIANA) IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 17 welfare Facioscapulohumeral muscular dystrophy: to define non invasive outcome measures and elucidate molecular mechanisms underlying muscle degeneration by means of longitudinal muscle MRI studies, immunological assessment and biomolecular characterization of a MONDINO Biomedical Musculoskeletal, Oral and Skin LAV BPIFB4 isoform, a new target to fight endothelial dysfunction MULTIMEDICA Biomedical Cardiovascular and Respiratory Early Neurorehabilitation in Neurosubintensive Care Unit Lombardia Clinical Brain Disorders and Clinical 17 Pagina 128 di 231

129 Development of novel chemoimmunotherapy strategy for hepatocellular carcinoma PASCALE Biomedical Oncology 2 Translational Clinical Oncology Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in breast cancer cells for metastatic tumor detection Lombardia Biomedical Surgical, Biomedical Imaging, and Bioengineering Oncology Impact of intensive follow up on diagnostic anticipation in high risk stage I III breast cancer patients. A phase II, multicenter randomized study. AOU San Martino IST Genova Clinical Oncology 2 Translational Clinical Oncology From bench to bedside in deciphering the modulatory mechanisms of the molecular damage in hereditary spastic paraplegias MEDEA Biomedical Brain Disorders and Clinical Developing an event based computational model of Alzheimer's disease progression incorporating quantitative MRI and TMS information to assist clinicians in the early diagnosis, correct prognosis, and treatment monitoring. SANTA LUCIA Clinical Brain Disorders and Clinical Compound Seropositivity of neutralizing antibodies against Adipogenic Adenoviruses (ADV36+ and ADV 37+): effect of nutritional intervention on overweightobesity, Non Alcoholic Fatty Liver Disease (NAFLD) and on Insulin Resistance. Sicilia Biomedical Digestive, Kidney and Urological Systems 17 Pagina 129 di 231

130 Estimate of Late diagnosis and Late presentation of HCV infection in high risk and hard to reach population. SPALLANZANI Clinical Infectious Diseases and Microbiology The Rac1 activator CNF1 as a therapeutic approach for amyotrophic lateral sclerosis ISS Biomedical Molecular, Cellular, and Developmental Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms AUXOLOGICO Biomedical Genes, Genomes and Genetics The new biotechnologies Apoptotic and DNA damage/repair mechanisms induced by anti neoplastic agents in mammalian oocytes of the ovarian reserve and strategies for fertility preservation in female patients. Lazio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Oncology Monitoring infection in complex wounds in pediatric patients OSPEDALE BAMBINO GESU' Clinical Healthcare Delivery and Methodologies EXOSOME MEDIATED CONTROL OF HEMATO ENDOTHELIAL CELL DIFFERENTIATION ISS Biomedical Cell Biology Oncology ROLE OF DORSOLATERAL PREFRONTAL CORTEX IN LONG TERM RECOGNITION MEMORY: TRANSCRANIAL MAGNETIC STIMULATION APPROACHES FOR TREATMENT OF LONG TERM MEMORY DEFICITS IN AMNESIC PATIENTS SANTA LUCIA Clinical Brain Disorders and Clinical Identifcation of the genetic landscape of T cell lymphoblastic lymphoma of childhood Veneto Biomedical Oncology 1 Basic Translational Oncology 17 Pagina 130 di 231

131 STRUCTURED PATHOLOGICAL REPORT IN ONCOLOGY.A DIGITAL NETWORK AMONG PATHOLOGY UNITS, TUMOR REGISTRIES AND REGIONAL HEALTH CARE SYSTEM. Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology CDKL5 DISORDER: identification of the molecular mechanisms underlying the neurological phenotype Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical New molecular predictive markers in Colorectal Cancer (CRC) Sicilia Biomedical Genes, Genomes and Genetics Oncology Exploiting the diagnostic, prognostic and therapeutic potential of micrornas in melanoma IDI Biomedical Oncology 2 Translational Clinical Oncology BIOSAFETY OF HUMAN MESENCHYMAL STEM CELLS: GENOMIC AND MEMBRANE STABILITY FOR A BETTER CLINICAL APPROACH Piemonte Biomedical Genes, Genomes and Genetics The new biotechnologies Development of guidelines for the management of cluster of cancer and other diseases in areas with environmental criticalities and translation for public health decision makers. Toscana Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Artificial Neural Network in development of Innovative Diagnostic systems for Atherosclerotic disease (The ANN IDA project) MONZINO Biomedical Surgical, Biomedical Imaging, and Bioengineering 17 Pagina 131 di 231

132 Atherogen Genetic Dyslipidemias (AGD): are they missed diseases?estimate of frequency of AGD diagnoses in the Tuscany hospitals and strategy design to identify probands with AGD and trigger early diagnosis in family members Toscana Clinical Healthcare Delivery and Methodologies Genetic and pharmacological inhibitors of the Epithelial Mesenchymal Transition REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology Role of adipose derived stem cells in chondrocyte functional impairment in metabolic osteoarthritis RIZZOLI Biomedical Musculoskeletal, Oral and Skin A new therapeutic approach against HPV cancer based on anti E6 and E7 scfv antibodies: validation in preclinical models and studies on the molecular mechanisms ISS Biomedical Oncology 2 Translational Clinical The new biotechnologies Metabolic tumour volume as assessed by 18F FDG PET/CT for tailoring therapy in patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiation. Liguria Clinical Oncology 2 Translational Clinical Oncology Chemotherapies of stem cells based solid vascularized tumors: from the bench to the bedside passing through equations I.E.O. Biomedical Bioengineering and Technologies Oncology 17, Effect of lower limb end effector robotassisted therapy with Virtual Realty on gait training in Parkinson Patients. SAN RAFFAELE Pisana Roma Clinical Biobehavioral and Behavioral Processes 17,25 Pagina 132 di 231

133 Forced Robotic Exercise Training effects on motor and cognitive functions of Parkinson's Disease patients Toscana Biomedical Emerging Technologies and Training in s 17, Neurocognitive deficits related to cardiosurgery intervention with extracorporeal circulation. Correlations between neuropsychological performances and functional MRI techniques (Spectroscopy, Diffusion and Morphometry) Toscana Clinical Brain Disorders and Clinical 17, Postactivation depression in hemiplegic stroke survivors: implications for assessment and treatment of spasticity AOU San Martino IST Genova Clinical Brain Disorders and Clinical 17, Culture and characterization of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency Veneto Biomedical Brain Disorders and Clinical The new biotechnologies 17, RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY MAUGERI Biomedical Cardiovascular and Respiratory 17, Evaluation of in vitro drug sensitivity and phosphoproteomic expression profiles in patients diagnosed with renal carcinoma REGINA ELENA Clinical Digestive, Kidney and Urological Systems Oncology 17, Nanomaterials and Health: a multilevel approach to study the effects of nanomaterials at workplaces INAIL Biomedical Bioengineering and Technologies Diseases of environmental origin, with reference also to the workplace 17,5 Pagina 133 di 231

134 Identification of biological and immune correlates of therapeutic responses for HPVpositive epithelial cancers: an ex vivo organotypic multi cellular model for patient tailored therapies. PASCALE Biomedical Oncology 1 Basic Translational Oncology 17, Signals from deregulated skin metabolism control generalized metabolic syndrome in psoriasis IDI Biomedical Musculoskeletal, Oral and Skin 17, In vitro assessment of lactic acid bacteria for suitability as probiotics in calves to improve health in newborns and to contrast neonatal mortality ISS Biomedical Veterinary Food safety and animal 17,5 welfare Role of DNA PK in neurodegeneration and aging: enhancement of DNA repair as novel therapeutic approach ISS Biomedical Brain Disorders and Clinical 17, Genomics of treatment response in acute myeloid leukemia I.E.O. Biomedical Oncology 2 Translational Clinical Oncology 17, IS IT TIME TO SELECT PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA (MPM) WHO MIGHT BENEFIT FROM AGGRESSIVE TREATMENT AND PROSPECTIVELY ANALYZE ONCOLOGIC AND FUNCTIONAL RESULTS? AOU San Martino IST Genova Clinical Oncology 2 Translational Clinical Oncology 17, SEPSIS TEAM: A MODEL OF INNOVATIVE MANAGEMENT OF THE PATIENT REFERRED TO EMERGENCY DEPARTMENT WITH A CONDITION OF SEVERE SEPSIS/SEPTIC SHOCK Emilia Romagna Clinical Infectious Diseases and Microbiology 17,5 Pagina 134 di 231

135 Endogenous obesogens accumulation and adipose tissue dysfunction: identification of toxogenomic, metabolomic and epigenetic signatures in adipocytes as a tool to understand environmental causes of human obesity AUXOLOGICO Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 17, Radiation exposure optimization by wireless technology for professionals involved in the management and care of patients undergoing therapy with radionuclides. Implementation of environmental monitoring. CROB Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 17, Molecular basis of Treatment Resistant Depression FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes 17, Molecular events underlying the metastatic potential of cancer stem cells Sicilia Biomedical Oncology 2 Translational Clinical Oncology 17, IDENTIFICATION OF NEW STRATEGIES TO IMPROVE THE OUTCOME OF TRAUMATIC BRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEW TARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Sicilia Biomedical Brain Disorders and Clinical 17, Evaluation of the olfactory function in the endoscopic trans nasal neurosurgical cancer patients: advanced medical technology and methodology Ist.Sci. Neurologiche Bologna Clinical Brain Disorders and Clinical 17,5 Pagina 135 di 231

136 Morphological and molecular phenotype of lung cancer in chronic obstructive pulmonary disease Veneto Biomedical Oncology 2 Translational Clinical Oncology 17, Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Biomedical Brain Disorders and Clinical 17, Identification of genetic variants associated with appropriate ICD therapy Provincia autonoma Bolzano Biomedical Cardiovascular and Respiratory 17, Novel PHOX2B defects and additional genes involved in the onset of Respiratory and Autonomic Disorders in Infancy, Childhood and Adulthood (RADICA): definition of pathogenic mechanisms and search for ameliorative drugs GASLINI Biomedical Genes, Genomes and Genetics 17, Determination of the dose distribution in patients treated with high energy photon beams using transmitted dose planar distributions measured with a new gas detector technology (Gas Electron Multipliers) and a dedicated backprojection algorithm. REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology 17, Neonatal development, neuro endocrine programming and mother child exposure to pesticides: a translational prevention study (NATAL) ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace 17,5 Pagina 136 di 231

137 Role of micrornas in esophageal carcinogenesis and the possible correlation between microrna serum levels and different stages of esophageal disease Sicilia Biomedical Oncology 1 Basic Translational Oncology 17, Active music therapy approach in the rehabilitation of stroke: a randomized controlled trial. MAUGERI Clinical Healthcare Delivery and Methodologies 17, Study and modelling of early alterations of microcirculation insepsis aimed at personalized treatment and identification of the outcome. Toscana Clinical Infectious Diseases and Microbiology 17, Characterization of specific factors that prevent HIV 1 induced cell death in Long Term Non Progressors and Elite Controllers. From pathogenesis to new treatments. SPALLANZANI Biomedical AIDS and Related Research 17, Immunologic, autonomic and metabolic components of exercise medicine in cancer survivors HUMANITAS Clinical Risk, Prevention and Health Behavior Oncology 17, Respiratory Syncytial Virus (RSV) infection in infants: the IFNs/ Ectonet axis as possible therapeutic target. ISS Biomedical Immunology 17, Melanoma: from next generation sequencing to personalized targeted therapy SAN GALLICANO Clinical Healthcare Delivery and Methodologies Oncology 17,5 Pagina 137 di 231

138 Age related evaluation of the usefulness of implantable cardiac defibrillator with or without cardiac resynchronization therapy: a real world analysis in patients with severe chronic heart failure Toscana Clinical Cardiovascular and Respiratory 17, Pathophysiology of obesity related vascular dysfunction: comparison between "metabolically healthy obesity" and the metabolic syndrome Lazio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 17, Circulating biomarkers as predictive and prognostic factors in patients with stage III melanoma: analysis of circulating melanoma cells (CMCs), circulating free DNA (cfdna) and molecular characterization of BRAF and NRAS mutational status in primary tumor Lombardia Biomedical Oncology 2 Translational Clinical Oncology 17, Single dose intravenous iron in patients with functional iron deficiency after acute myocardial infarction: impact on hospitalacquired anemia, cardiovascular and functional status AUXOLOGICO Clinical Cardiovascular and Respiratory 17, A wait and see approach to identify predictors of aggressiveness in sporadic desmoid tumor IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 17, Origin and significance of residual viremia in virologically suppressed HIV infected patients. SPALLANZANI Biomedical AIDS and Related Research 17,5 Pagina 138 di 231

139 Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration: role of genome instability associated with tau mutations CARLO BESTA Biomedical Brain Disorders and Clinical 17, PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATIONFOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Biomedical Infectious Diseases and Microbiology 17, Evaluation of the pathogenetic role of Parvovirus B19V in systemic sclerosis and autoimmune thyroiditis. Toscana Clinical Immunology 17, Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours ISS Biomedical Oncology 2 Translational Clinical Oncology 17, Investigating the relationship between animal farming and antibiotic resistances in natural or environmental prokaryotic communities IZS Venezie Biomedical Veterinary Food safety and animal 17,5 welfare CDKs blockade for molecular targeting in human cancer. C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 17, ANALYSIS OF THE GENETIC AND EPIGENETIC BASIS OF HCV RELATED LYMPHOPROLIFERATIVE DISORDERS Toscana Biomedical Infectious Diseases and Microbiology Oncology 17,5 Pagina 139 di 231

140 Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study ARCISPEDALE Reggio Emilia Clinical Musculoskeletal, Oral and Skin 17, MicroRNA: new markers for the diagnosis of occult hepatitis B ISS Biomedical Infectious Diseases and Microbiology The new biotechnologies 17, NAFLD (Non Alcoholic Fatty Liver Disease) : which relationship of liver steatosis and concurrent fibrosis with heart function. Sicilia Clinical Digestive, Kidney and Urological Systems 17, Ageing at work: promoting health and safety of ageing workers according to changes of demography, labourmarket and social policies. MAGGIORE Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 17, In vivo identification of molecular determinants critical to the metastatic process in melanoma. I.E.O. Biomedical Oncology 1 Basic Translational Oncology 17, Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cell and gamma/delta T lymphocytes and regulation of their cross talk ISS Biomedical Immunology 17, The potential of the SRCIN1/p140Cap gene as prognostic risk factor and tumor suppressor in neuroblastoma GASLINI Biomedical Oncology 1 Basic Translational Oncology 17,5 Pagina 140 di 231

141 Oxidative stress in animal cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumors IZS Piemonte, Liguria e Valle d'aosta Biomedical Oncology 1 Basic Translational Oncology 17, HIV eradication: pharmacological modulation of HIV latent reservoir by targeting of sirtuin family of de acetylating enzymes Sicilia Biomedical AIDS and Related Research 17, Targeting endothelin 1/ß arrestin signaling to circumvent chemoresistance in epithelial ovarian cancer REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology 17, Behavioural and neurophysiological aspects of communicative pragmatic abilities in healthy individuals and pathological conditions: assessment and rehabilitation MEDEA Biomedical Brain Disorders and Clinical 17, Treatment of advanced or recurrent endometrial cancer: identification of molecular predictors of response in a randomized phase II study with Bevacizumab in combination to Carboplatin Paclitaxel IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 17, Multimodal nanotechnological approach against hepatocellular carcinoma: Sorafenib loaded magnetic nanoparticles for targeted chemotherapy and localized hyperthermia. Toscana Biomedical Oncology 2 Translational Clinical Oncology 17,75 Pagina 141 di 231

142 Identification and biomolecular characterization of circulating tumor cells from patients with ovarian epithelial cancer using tumor specific fluorescent ligands: A new in vivo non invasive method. I.E.O. Clinical Oncology 2 Translational Clinical Oncology Pathophysiological approach to the interventional therapy of limb atherosclerotic disease A biomedical, mechanistic study Emilia Romagna Biomedical Vascular and Hematology DEVELOPMENT OF ADVANCED NANOTECHNOLOGIES FOR EARLY ALZHEIMER DIAGNOSIS: FROM THE SYNTHESIS TO THE CLINICAL VALIDATION Puglia Biomedical Bioengineering and Technologies The activation of vestibular system as a possible tool for inducing analgesia, speeding up recovery from stroke and facilitating recovery from vegetative and minimal conscious state Toscana Biomedical Brain Disorders and Clinical Development of innovative compounds for the treatment of renal cell carcinoma Abruzzo Biomedical Oncology 2 Translational Clinical Oncology Safety of workers with implanted medical devices in MRI environment: criteriafor occupational risk evaluation ISS Biomedical Surgical, Biomedical Imaging, and Bioengineering Diseases of environmental origin, with reference also to the workplace DENOSUMAB FOR THE TREATMENT OF SYSTEMIC SCLEROSIS RELATED OSTEOPOROSIS: AN OPEN LABEL PILOT SAFETY STUDY. Basilicata Clinical Musculoskeletal, Oral and Skin The new biotechnologies 18 Pagina 142 di 231

143 Epigenetic change in DNA structure may serve as marker for neurological disease Marche Biomedical Brain Disorders and Clinical Therapeutic strategies in refractory chronic daily headache: A multicenter, randomized, controlled trial. Ist.Sci. Neurologiche Bologna Clinical Emerging Technologies and Training in s Occupational and non occupational risk factors for retinal detachment: a multicentre population based case control study Emilia Romagna Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Memory training with transcranial direct current stimulation (tdcs) and cognitive reserve in Multiple Sclerosis and Alzheimer disease. A longitudinal clinical and MRI study Lombardia Clinical Brain Disorders and Clinical Pre eclampsia: the role of genetics in understanding the etiopathogenesis and evaluation of early predictive biomarkers SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies Development of functionalized magnetic nanoparticles (VIVIT MNP) for IBD treatment: possible involvement of NFAT transcription factor Lombardia Biomedical Bioengineering and Technologies The new biotechnologies Impact of JC and BK polyomaviruses infection on human infertility and recurrent pregnancy loss Emilia Romagna Biomedical Infectious Diseases and Microbiology 18 Pagina 143 di 231

144 Role of GALNT2 on glucose homeostasis. A multidisciplinary approach including cell biology, animal and human studies. CASA SOLLIEVO SOFFERENZA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive A genomic and proteomic approach to explore phenotype variability in Gerstmann Sträussler Scheinker syndrome (GSS) linked to P102L mutation in the PRNP gene ISS Biomedical Brain Disorders and Clinical Oleuropein aglycone can be effective against AD in humans. A clinical trial Toscana Biomedical Brain Disorders and Clinical Non Invasive Monitoring of Circadian Rhythm Disorders In Shift workers I.N.R.C.A. Clinical Biobehavioral and Behavioral Processes Diseases of environmental origin, with reference also to the workplace Identification and protein profiling of extracellular vesicles in the cerebrospinal fluid of patients with Mild Cognitive Impairment and Alzheimer s disease: a new potential diagnostic tool Piemonte Biomedical Brain Disorders and Clinical The role coagulation/complement upregulation and neurotropic viral activation play in Multiple Sclerosis REGINA ELENA Clinical Brain Disorders and Clinical Telomere targeting agents: Towards clinical candidates selections REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology Study of molecular based approach for the epidemiological characterization of strains of Listeria monocytogenes isolated in food and human cases in Italy IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 18 welfare Pagina 144 di 231

145 High resolution molecular cytogenetics in colorectal cancer and oral premalignant lesions. Sicilia Biomedical Oncology 1 Basic Translational Oncology Chemoprevention of radiation damages induced by radiodiagnostic procedures REGINA ELENA Clinical Surgical, Biomedical Imaging, and Bioengineering Oncology Organic pollutant and plastic associated chemical effects on s: a sex gender issue Toscana Clinical Cardiovascular and Respiratory Diseases of environmental origin, with reference also to the workplace Cockayne syndrome: the role of bioenergetics dysfunction in neurodegeneration and design of new therapeutic approaches ISS Biomedical Molecular, Cellular, and Developmental Cancer and adolescence: what clinical and sociological approach? A preliminary project in Italy C.R.O. AVIANO Clinical Healthcare Delivery and Methodologies Oncology New targets for therapy in breast cancer: dietary induced inhibition of mammalian target of rapamycin (mtor) SDN Biomedical Oncology 2 Translational Clinical Oncology Inhibition of the Hedgehog Signaling Pathway for the Treatment of Patients with Osteosarcoma Toscana Biomedical Oncology 2 Translational Clinical Oncology 18 Pagina 145 di 231

146 OBESITY AND DIABETES/HYPERTENSION RISK IN CHILDREN: PREVENTION AND TREATMENT THROUGH MONITORED PHYSICAL ACTIVITY and NUTRITION PROGRAMS SAN RAFFAELE Pisana Roma Clinical Endocrinology, Metabolism, Nutrition and Reproductive Lipoprotein(a) and soluble lectin like oxidized LDL receptor 1 (slox 1) as a potential causal genetic risk factor for atherosclerosis in a prospective populationbased study (PLIC study) Lazio Biomedical Vascular and Hematology Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a GASLINI Biomedical Genes, Genomes and Genetics Food Safety: protection of the public health through the determination of some endocrine disruptors in water and foods of large consumption IZS Mezzogiorno Biomedical Veterinary Food safety and animal 18 welfare IS THERE A "SMELLING SIDE" IN THE HUMAN MOTOR SYSTEM? Towards a clinical relevance of olfacto motor crossmodal intercations Toscana Clinical Brain Disorders and Clinical Counteracting oxidative stress in Rett syndrome ISS Biomedical Brain Disorders and Clinical Mechanism of action and in vivo efficacy of anti inflammatory treatments in Treg induction, regulation of neuroinflammation and arrest of dementia progression. NEUROLESI Biomedical Brain Disorders and Clinical 18 Pagina 146 di 231

147 Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, CostEffective Algorithm Sicilia Clinical Digestive, Kidney and Urological Systems Oncology PYB Protect Your Back (Effectiveness of Back Protector in preventing spinal cord injuries) ISS Biomedical Risk, Prevention and Health Behavior Early discharge from the emergency department of nursing home dwelling older patients with community acquired pneumonia in comparison to normal hospitalization: a randomized clinical trial Toscana Clinical Healthcare Delivery and Methodologies A novel TRAIL based therapeutic by mesenchymal cells TARgeting PAncreatic Cancer (TARPAC) Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology Nuclear Signaling Mediated by the Innate Immune/Inflammtory Kinase PKR as a Therapeutic Target and Prognostic Indicator of Disease Progression and Therapeutic Response in Myelodysplastic Syndromes and Acute Leukemia RIZZOLI Biomedical Vascular and Hematology Oncology EXOME SEQUENCING BASED DETECTION OF VARIANTS RELEVANT TO THE CLINICAL SPECTRUM OF NEONATAL BRONCHO PULMONARY DYSPLASIA AND RESPIRATORY DISTRESS SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics The new biotechnologies 18 Pagina 147 di 231

148 Biological endophenotypes associated to the electroconvulsive therapy in treatment resistant depression. Provincia autonoma Bolzano Biomedical Biobehavioral and Behavioral Processes Correlation between estrogen depletion and Alzheimer s disease: analysis of gene expression and brain functions in humans and animal models OASI MARIA S.S. Biomedical Integrative, Functional, and Cognitive Reduction of atrial fibrillation and stroke in systemic arterial hypertension: a randomized control trial comparing routine SAN DONATO Clinical Cardiovascular and Respiratory 18 medical treatment versus primary care physicians guided drug regiment delivery through intensive blood pressure monitoring Development of a multi stage vaccine against tuberculosis Veneto Biomedical Immunology Improving radiotherapy of high grade gliomas by Ataxia Telangiectasia Mutated protein inhibition AOU San Martino IST Genova Biomedical Brain Disorders and Clinical Oncology Implementation of the Montreal Cognitive Assessment as a standard neuropsychological screening tool in Italian stroke units Toscana Clinical Brain Disorders and Clinical 18 Pagina 148 di 231

149 Occupational Mycobacterium tuberculosis infection among healthcare workers: assessing the burden and developing modern strategies for risk assessment and health surveillance SPALLANZANI Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Study of new biomarkers for diagnoses of disorders of bile acid synthesis by mass spectrometry and metabolomics approach Veneto Biomedical Digestive, Kidney and Urological Systems CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY: A NATIONAL IMMUNOMONITORING NETWORK ISS Biomedical Immunology Study on the use of vodcast in the treatment of Anorexia Nervosa Veneto Clinical Biobehavioral and Behavioral Processes Genetic polymorphisms in genes of drugrelated and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma I. O. V. Biomedical Oncology 2 Translational Clinical Oncology The early identification of newborns at high risk of brain injury: the role of oxidative stress. Toscana Clinical Brain Disorders and Clinical Translational value of pathophysiological pathways and therapeutic agents on lipid dysmetabolism in the hepatobiliary and cardiovascular system: a bench to bedside project. Puglia Biomedical Healthcare Delivery and Methodologies 18 Pagina 149 di 231

150 Two innovative rapid screening methods of corticosteroids as growth promoters in cattles using MEAs and an enhanced histopathological approach IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 18 welfare Mechanisms of extracranial organ damage after acute brain injury: role of protective mechanical ventilation in reducing incidence of acute respiratory distress syndrome and attenuating systemic inflammation in acute neurologically ill patients Piemonte Biomedical Cardiovascular and Respiratory Treatment of Subsyndromal Delirum (SSD) and long term Cognitive Dysfunction after Cardiac Surgery. Evaluation of possible neural mechanism underlyning Delirium Emilia Romagna Clinical Integrative, Functional, and Cognitive Impact of HIV on the pathogenesis of Mycobacterium tuberculosis: autophagy involvement and new pharmacological target SPALLANZANI Biomedical Infectious Diseases and Microbiology 18, Phase I/II clinical trial of dendritic cell therapy for the treatment of metastatic melanoma based on an innovative way to generate a whole repertoire of tumor peptides via gap junction pores I.E.O. Clinical Oncology 2 Translational Clinical Oncology 18, THROMBOTIC MARKERS AS INNOVATIVE TOOLS FOR CANCER PROGNOSIS IN ONCOLOGICAL PATIENTS UNDERGOING HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY Lombardia Biomedical Oncology 2 Translational Clinical Oncology 18,25 Pagina 150 di 231

151 EFFECTS OF BLUNTING DAILY GLUCOSE FLUCTUATIONS ON COGNITIVE PERFORMANCE IN AGED TYPE 2 DIABETIC PATIENTS I.N.R.C.A. Clinical Endocrinology, Metabolism, Nutrition and Reproductive 18, FUNCTIONAL PROFILING OF MONOCYTE/MACROPHAGE POPULATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA: INVOLVEMENT IN CLINICAL OUTCOME Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology 18, Daily monitoring of pediatric asthmatic outpatients: environment and health relationship. OSPEDALE BAMBINO GESU' Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 18, Cellular autoimmunity and causative autoantigens in acquired thrombotic thrombocytopenic purpura (TTP) MAGGIORE Biomedical Immunology 18, Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV 1 infection and reactivation from latency ISS Biomedical AIDS and Related Research 18, Systemic and local characterization of clinical remission in rheumatoid arthritis patients treated with biologic agents: predictors, dynamics and pathologic stability. SAN MATTEO Biomedical Musculoskeletal, Oral and Skin 18, Human Cardiac Stem Cell Regenerative Capacity in Paediatric Heart Failure Lazio Biomedical Cardiovascular and Respiratory 18,5 Pagina 151 di 231

152 Genetic and Antigenic Evolution of West Nile virus Isolated in Italy and Characterization of Viral Host Mechanisms Regulating Infection and Pathogenesis IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 18,5 welfare RISK OF INFECTION IN RHEUMATOID ARTHRITIS (RA): INVOLVEMENT OF INNATE IMMUNITY AND BIOLOGIC THERAPIES. Campania Biomedical Immunology 18, Superpolyps: superantigen induced T and B cell accumulation in nasal polyps Lombardia Clinical Infectious Diseases and Microbiology 18, Biomolecular serological and epidemiological investigations on Encefalomyocarditis virus and his zoonotic roles in Italy. IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 18,5 welfare Development and implementation of a protocol for communication of genetic information and multidisciplinary genetic counseling in ALS, in parallel with identification of early alterations in presymptomatic ALS. Piemonte Clinical Brain Disorders and Clinical 18, PREDICTION OF AWAKENING FROM ACUTE COMA, USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS. Veneto Clinical Brain Disorders and Clinical 18,5 Pagina 152 di 231

153 micrornas and Single Nucleotide Polymorphisms as potential screening biomarkers for early detection of colorectal cancer. Toscana Biomedical Oncology 1 Basic Translational Oncology 18, Appropriateness of systemic anticancer therapy in advanced cancer patients: the use of AIFA monitored antineoplastic drugs in the end of life in Regione Emilia Romagna Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology 18, A Web Intelligence approach to the patient empowerment: exploring knowledge on internet conversations C.R.O. AVIANO Clinical Healthcare Delivery and Methodologies Oncology 18, New insights for Attention Deficit and Hyperactivity Disorder (ADHD): novel serotonin 7 receptor agonist drugs for putative therapy, and clinical validation of the circulating auto Antibodies against DAT as a bio marker for diagnosis. ISS Biomedical Biobehavioral and Behavioral Processes 18, mirna in the blood as biomarkers and therapeutic indicators of progressive tissue degeneration in Glycogen Storage Disease type 1a patients GASLINI Biomedical Genes, Genomes and Genetics 18, Expression of indoleamine 2,3 dioxygenase 1 (IDO1) in childhood acute leukemia: mechanisms of induction/regulation and clinical implications for leukemia control and patient survival. OSPEDALE BAMBINO GESU' Biomedical Immunology Oncology 18,5 Pagina 153 di 231

154 Novel Plasmodium falciparum cell based assays for new antimalarial drugs ISS Biomedical Infectious Diseases and Microbiology 18, MITOCHONDRIAL CI and CIV DEFICIENCIES: DIFFERENT CLINICAL AND BIOCHEMICAL RENSPONSE TO EPI 743. AN INTEGRATED APPROACH TO IMPROVE BOTH THE CLINICAL MANAGEMENT AND THE UNDERSTANDING OF THE PATHOGENESIS OF THIS DISORDER OSPEDALE BAMBINO GESU' Biomedical Brain Disorders and Clinical 18, Measuring outcomes to estimate the value of health interventions in breast cancer care C.R.O. AVIANO Clinical Healthcare Delivery and Methodologies Oncology 18, How is it possible to define rehabilitation care appropriateness? The impact of an alternative evaluation system on the inappropriateness of health care resources Emilia Romagna Clinical Healthcare Delivery and Methodologies 18, Pulmonary Rehabilitation in Lung Cancer surgical patients. SAN RAFFAELE Pisana Roma Clinical Cardiovascular and Respiratory Oncology 18, MULTIMODAL APPROACH TO PERSONALIZED THERAPY IN ANAL CANCER: CREATION OF A BIOMARKER PREDICTIVE PROFILE ADDRESSING TOWARDS NEW THERAPUTIC STRATEGIES Piemonte Clinical Oncology 2 Translational Clinical Oncology 18, Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 18,5 Pagina 154 di 231

155 Comparative study on the clinical efficacy and manegement of different feeding strategies in elderly patients with advanced dementia. Veneto Clinical Endocrinology, Metabolism, Nutrition and Reproductive 18, Mechanism(s) underlying differential protection of trastuzumab containing therapy depending on site of relapse. IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology 18, Smoking reduction in a population at high risk of cardiovascular mortality. Randomized control trial of intervention to implement and improve tobacco control strategies in psychiatric settings versus combined pharmacological and psychological intervention Provincia autonoma Trento Clinical Risk, Prevention and Health Behavior 18, Fighting drug resistance in non small cell lung cancer (NSCLC): a combinatorial approach based on anti Kit ligand vaccination Piemonte Biomedical Oncology 2 Translational Clinical Oncology 18, Risk of human and animal exposure to cyanotoxins through fresh and brackishwater reared organisms in connected ponds systems IZS Sardegna Biomedical Veterinary Food safety and animal 18,5 welfare In vivo manipulation of gamma delta Tcell with zoledronate and low dose IL2: improving the efficacy of BRAF inhibitors through a combined targeted/immunotherapy in metastatic melanoma. Sicilia Clinical Oncology 2 Translational Clinical Oncology 18,5 Pagina 155 di 231

156 HOMEOSTASIS OF ph AND BICARBONATE CONCENTRATION IN THE AIRWAY SURFACE FLUID AS A TARGET FOR THE TREATMENT OF RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS AND OTHER CHRONIC LUNG DISEASES GASLINI Biomedical Cell Biology 18, A novel approach for detecting vectorborne viruses in Sardinia and evaluation of Bluetongue virus evolution. IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 18,5 welfare Evaluation of clinical feasibility and effectiveness of a robotic device for early stage rehabilitation of stroke patients Provincia autonoma Bolzano Biomedical Emerging Technologies and Training in s 18, Congenital cytomegalovirus infection: prognostic factors of virus transmission to the fetus and congenital disease SAN MATTEO Biomedical Infectious Diseases and Microbiology 18, NEW ANTIBACTERIAL COATINGS FOR TITANIUM PROSTHESIS TO REDUCE PERIMPLANT INFECTIVE RISK AND IMPROVE OSSEOINTEGRATION RIZZOLI Biomedical Musculoskeletal, Oral and Skin The new biotechnologies 18, Generation of human artificial striated muscle MULTIMEDICA Biomedical Bioengineering and Technologies The new biotechnologies 18, Implementation of a pathology network to improve identification and clinical management of patients with familial hypercholesterolemia MULTIMEDICA Clinical Healthcare Delivery and Methodologies 18,5 Pagina 156 di 231

157 The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson's Disease OASI MARIA S.S. Biomedical Brain Disorders and Clinical 18, BIOLOGICAL AGING AND URBAN POLLUTION Veneto Biomedical Cardiovascular and Respiratory Diseases of environmental origin, with reference also to the workplace 18, Alteration of steroid hormone pathways and vitamin D in testicular germ cell tumors PASCALE Biomedical Oncology 2 Translational Clinical Oncology 18, MEDITERRANEAN DIET AND RECURRENCE OF COLORECTAL ADENOMA AND CANCER : A RANDOMIZED CONTROLLED TRIAL DE BELLIS Biomedical Risk, Prevention and Health Behavior Oncology Impact of the association between elastography and fine needle aspirate mutational testing in the prediction of malignancy of thyroid nodules with indeterminate cytology: a prospective analysis. Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Role of Type I Interferon in the Cross talk between Neutrophils and Dendritic Cells in the induction of adaptive immunity during Mycobacterium tuberculosis and BCG infections. ISS Biomedical Immunology Development of an artificial larynx for clinical applications Toscana Biomedical Biobehavioral and Behavioral Processes The new biotechnologies 19 Pagina 157 di 231

158 Developmemt of a novel intra operative spectroscopic diagnostic technology for diagnosis and better delineation of human brain tumours. Toscana Biomedical Oncology 2 Translational Clinical Integration of Diagnostic tools for fibromyalgia: can tailored therapies be more effective and less expensive? Piemonte Biomedical Integrative, Functional, and Cognitive Predictive value of invasive measurement of left ventricular function during cardiac resynchronization therapy (CRT). Sicilia Clinical Cardiovascular and Respiratory Multifunctional Targeted Nanoparticles for minimally Invasive Diagnosis and Therapy of Inflammatory Bowels Diseases and their displasic lesions. I. O. V. Biomedical Digestive, Kidney and Urological Systems The new biotechnologies Bowel microbiota and chronic inflammatory bowel diseases: a metabolomic approach Sardegna Biomedical Infectious Diseases and Microbiology Cognitive rehabilitation after stroke: a randomized controlled trial to compare the effectiveness of different protocols. Sicilia Clinical Brain Disorders and Clinical The early diagnosis of Alzheimer disease: new tools for the olfactory dysfunction evaluation. Toscana Clinical Brain Disorders and Clinical Molecular techniques as epidemiological tools to answer some of the queries about Q fever IZS Venezie Biomedical Veterinary Food safety and animal 19 welfare Pagina 158 di 231

159 Development of a novel immunotherapeutic approach to contrast prion mediated Abeta oligomer neurotoxicity by intracellular antibody technology SAN RAFFAELE Pisana Roma Biomedical Brain Disorders and Clinical MIND THE GAP: END OF LIFE IN ADVANCED HEART FAILURE. IMPROVING QUALITY AND CARE OPTIONS. Toscana Clinical Healthcare Delivery and Methodologies Finding of common potential new biomarkers for development of diagnostic tools in different neurodegenerative diseases and discovery of new therapeutic agents IZS Sicilia Biomedical Cell Biology Identification of novel molecular mechanisms promoting oncogenic RAS signaling ISS Biomedical Oncology 1 Basic Translational Oncology EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND INFLAMMATION AND ON OXIDATIVE STRESS INDUCED UNFOLDED PROTEIN RESPONSE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: RELATION WITH ARTERIAL STIFFNESS AND LUNG FUNCTION DECLINE Veneto Clinical Cardiovascular and Respiratory Lentiviral mediated telomere stabilization in hematopoietic stem cell transplantation for graft improvement and GVHD reduction in thalassemia patients Sardegna Clinical Vascular and Hematology The new biotechnologies 19 Pagina 159 di 231

160 Report AGE Project: clinical and molecular predictors of frailty in aged hospitalized populations with s I.N.R.C.A. Clinical Biology of Development and Aging Ultrasound on bioeffects and safety: an integrated approach in evaluating ultrasound mediated cell alterations at both cell membrane and genetic level INAIL Biomedical Cell Biology Diseases of environmental 19 origin, with reference also to the workplace Fractal Lacunarity of Trabecular Bone in Magnetic Resonance Images of Lumbar Vertebras: Clinical Validation of a New Diagnostic Tool for Osteoporosis and Fracture Risk I.N.R.C.A. Clinical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies Cellular biomarkers of diabetic pathophysiology and complications Veneto Biomedical Cardiovascular and Respiratory Developement and characterization of a new single step treatment for multiple orthopaedic diseases affecting bone or cartilage with the use of bone marrow derived cells and collagenic scaffold RIZZOLI Biomedical Bioengineering and Technologies The new biotechnologies (SIMBA) Simulation Interface for Miniaturized preterm BAby respiratory system model Toscana Clinical Bioengineering and Technologies The new biotechnologies Metabolomics of Multiple Myeloma SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 19 Pagina 160 di 231

161 Optimization, on the basis of Monte Carlo dosimetry, of the therapeutical effectiveness and toxicity of Peptide Receptor Radionuclide Therapy in patients with neuroendocrine tumors Sicilia Clinical Oncology 2 Translational Clinical Oncology Nanoparticle Enhanced Surface Plasmon Resonance Imaging (NE SPRI): PCR free ultrasensitive cancer prognosis and therapy prediction REGINA ELENA Clinical Oncology 2 Translational Clinical The new biotechnologies Using available stimulation techniques to delay the onset of dementia S.CAMILLO Clinical Brain Disorders and Clinical Identification of molecular targets and markers to manage hormone resistant obesity associated breast cancer: from in vitro and in vivo models to human tumors Piemonte Biomedical Oncology 2 Translational Clinical Oncology Project title: CEACAM1 is a priviliged cell surface target antigen to design human mabs in scfv format for multimodal immunotherapeutic intervention of melanoma and lung carcinoma. ISS Biomedical Bioengineering and Technologies The new biotechnologies Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Biomedical Brain Disorders and Clinical Antibiotic strategy and response to microbiologic tests: a study of appropriateness and promptness in case of sepsis. Piemonte Clinical Infectious Diseases and Microbiology 19 Pagina 161 di 231

162 Property of donkey's milk : application in human nutrition and its potential usein the preventions and therapy of metabolic infiammatory and s associated with obesity. IZS Mezzogiorno Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Early detection of cardiotoxicity in cancer patients ONCOLOGICO DI BARI Clinical Cardiovascular and Respiratory Oncology ENDOCRINE AND INTRACRINE METABOLISM OF SEX STEROIDS PROSTATE HEALTH AND CANCER OUTCOMES FROM A 20 YEAR POPULATION BASED STUDY SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology 19, Fertility preservation in young Oncological female patients REGINA ELENA Clinical Endocrinology, Metabolism, Nutrition and Reproductive Oncology 19, Proximal versus Distal approach in the upper limb rehabilitation in stroke patients using robotic platforms: effects on the motor performance and functional recovery. SAN RAFFAELE Pisana Roma Clinical Biobehavioral and Behavioral Processes 19, Alternative strategies for cognitive rehabilitation after stroke: which role for not invasive brain stimulation? Effects of transcranial magnetic stimulation in recovery of hemispatial attention and language in subacute and chronic patients. Sicilia Clinical Brain Disorders and Clinical 19,5 Pagina 162 di 231

163 NEUROPSYCHOLOGICAL AND fmri STUDIES TO EVALUATE THE EFFECTS OF COGNITIVE REHABILITATION IN PARKINSON S DISEASE Provincia autonoma Trento Clinical Integrative, Functional, and Cognitive 19, Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy andgive new insight into monogenic type 2 diabetes OSPEDALE BAMBINO GESU' Biomedical Digestive, Kidney and Urological Systems 19, Immunological and virological predictors of clinical outcome in chronic HBV patients discontinuing anti viral treatment SPALLANZANI Biomedical Immunology 19, Role of plasma dysregulated micrornas in the diagnosis and screening of Human Malignant Pleural Mesothelioma (MPM) Emilia Romagna Biomedical Oncology 2 Translational Clinical Diseases of environmental 19,5 origin, with reference also to the workplace Effects of a late add on therapy of pegylated interferon (peg IFN ) to ongoing nucleos(t)ide analogs (NUCs) in patients with chronic hepatitis B (CHB): dissecting systemic and hepatic immune restoration Lombardia Clinical Infectious Diseases and Microbiology 19, zec zero Errors in Chemotherapy: process modelling for more effective ICT solutions in antiblastic treatment management I.E.O. Clinical Healthcare Delivery and Methodologies Oncology 19, The impact of HBV and HCV expression and replication on cellular differentiation, metabolism and oncogenesis in extra or intra hepatic stem cells induced to differentiate along the hepatocytic lineage SPALLANZANI Biomedical Infectious Diseases and Microbiology 19,5 Pagina 163 di 231

164 Rapid eye movement sleep behavior disorder (RBD): Prevalence study in Italian general population aged > 50 years SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 19, Development and monitoring of a Parkinson's disease network in Tuscany Toscana Clinical Brain Disorders and Clinical 19, Discovery and translational research of aggressive B cell lymphomas of still unknown pathobiology Toscana Biomedical Oncology 1 Basic Translational Oncology 19, Predictive and prognostic value of molecular markers for glioma in clinical decision making CARLO BESTA Clinical Oncology 2 Translational Clinical Oncology 19, Identification of biomarkers associated with clinical response and/or toxicity to treatment with the JAK2 inhibitor ruxolitinib in patients with myelofibrosis Toscana Biomedical Oncology 2 Translational Clinical Oncology 19, High coverage next generation sequencing to detect the presence and intra tumor frequency of mutations in the EGFR pathway activating genes: predictive value on the response to anti EGFR therapy in metastatic colorectal cancer. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology 19, SISTEMATIC APPLICATION OF A STANDARDIZED COMPREHENSIVE GERIATRIC ASSESSMENT TO PREDICT OUTCOME AND POSSIBILITY OF TREATMENT ON ELDERLY CANCER PATIENTS Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology 19,5 Pagina 164 di 231

165 Exposure and health effects of Ultrafine Particles at urban hotspots INAIL Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 19, Application of novel biotechnologies for assessment of the vector competence of wild populations of Culicoides obsoletus for the Bluetongue virus IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 19,5 welfare A Prospective Cohort Study to Evaluate the Prognostic Value of Mobile Genetic Element Insertions in Non Small Cell Lung Cancer (NSCLC). I.N.R.C.A. Clinical Oncology 2 Translational Clinical Oncology 19, Characterization of molecular markers that are associated with DNA damage repair pathways to identify rectal cancer patients who are responsive to chemioradiotherapy Piemonte Biomedical Oncology 2 Translational Clinical Oncology 19, Definition of a new predictive model to assess the complexity of patients hospitalized in Internal Medicine, with particular reference to cardiovascular outcomes Lombardia Clinical Healthcare Delivery and Methodologies 19, Validation of a Prognostic Gene Signature in Urine Samples from Prostate Cancer Patients SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 19, New molecurar markers to characterize benign and malignant thyroid cells. Toscana Biomedical Oncology 2 Translational Clinical Oncology 19,5 Pagina 165 di 231

166 Post transplant hematopoiesis: a model to understand self renewal mechanisms of hematopoietic stem cells GASLINI Biomedical Vascular and Hematology Oncology 19, The gc1q domain of EMILIN1 as an ideal backbone to develop a versatile drug carrier C.R.O. AVIANO Biomedical Oncology 2 Translational Clinical Oncology 19, Genetic basis of taste perception, life style, health status and colorectal cancer risk. Piemonte Biomedical Genes, Genomes and Genetics Oncology 19, Personalized multidisciplinary therapy in head and neck cancer based on clinical and molecular markers C.R.O. AVIANO Clinical Oncology 2 Translational Clinical Oncology 19, Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. OASI MARIA S.S. Biomedical Genes, Genomes and Genetics 19, The effects of intensive arm training on upper extremity motor recovery in chronic stroke survivors. Identification of biomarkers related to clinical outcome. Emilia Romagna Clinical Brain Disorders and Clinical 19, Evaluation of denosumab effects on RANKL/RANK signalling in human osteosarcoma cells. Abruzzo Biomedical Oncology 1 Basic Translational Oncology 19, Oxidative stress and vitamin D as potential contributors for cardiometabolic complications in subclinical and overt hypothyroidism. Toscana Clinical Cardiovascular and Respiratory 19,5 Pagina 166 di 231

167 Phase contrast mammography with synchrotron radiation in the follow up of patients treated with conservative surgery for breast carcinoma Friuli Venezia Giulia Biomedical Surgical, Biomedical Imaging, and Bioengineering Oncology 19, Genetic risk prediction of atrial fibrillation recurrences: new insight from next generation sequencing Emilia Romagna Clinical Genes, Genomes and Genetics 19, Antenatal human heart development Lombardia Clinical Cardiovascular and Respiratory 19, Host pathogen interactions: Chlamydiae cronic infections; a primary role in human diseases. Biomarkers and diagnostic tools for clinical evaluation. Toscana Biomedical Infectious Diseases and Microbiology 19, Longitudinal comparative study to assess progression and predictive factors of ognitive decline in patients with advanced Parkinson's disease treated with deep brain stimulation of the subthalamic nucleus stimulation and pharmacological therapy S.CAMILLO Clinical Brain Disorders and Clinical 19, INNOVATIVE TRANSLATIONAL APPROACHES TO IDENTIFY IMMUNE CORRELATES OF PROTECTION IN AIDS VACCINE TRIALS ISS Biomedical AIDS and Related Research Decision making and learning impairments associated with focal cerebral lesions Lazio Clinical Integrative, Functional, and Cognitive 20 Pagina 167 di 231

168 Understanding high risk HPV induced derangements in cervical cancer to address patients' prognosis and therapy and to defeat the viral oncogenic machinery REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology Investigations of the molecular mechanisms linking poly(adp ribosyl)ation to relapses and progression of multiple sclerosis Toscana Biomedical Brain Disorders and Clinical In vitro and in vivo effects of posttransplant cyclophosphamide (PT CY) in patients receiving hematopoietic stem cell transplantation from HLA haploidentical family donors. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology Familial Hyperaldosteronism: Studies in Humans and in Animal Models Piemonte Biomedical Genes, Genomes and Genetics GENE ENVIRONMENT INTERACTIONS, VITAMIN D STATUS AND SUSCEPTIBILITY: IMMUNE RESPONSE AND PULMONARY TUBERCULOSIS RISK IN SICILY Sicilia Biomedical Population and Epidemiology ROLE OF GROUP I METABOTROPIC GLUTAMATE RECEPTORS IN THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS AND IN ITS PHARMACOLOGICAL CONTROL I.N.R.C.A. Biomedical Brain Disorders and Clinical Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health ISS Biomedical Oncology 2 Translational Clinical Oncology 20 Pagina 168 di 231

169 ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia Romagna Biomedical Immunology Orthopoxvirus infection in Italy: diffusion and evaluation of innovative vaccine candidates SPALLANZANI Biomedical Infectious Diseases and Microbiology An integrated genomic and immunological approach to novel monitoring and therapeutic strategies for HBV and HCV infections Emilia Romagna Biomedical Infectious Diseases and Microbiology Achieving mucosal and systemic immunity by exploiting vitamin A metabolites as coadjuvants in Tuberculosis vaccination ISS Biomedical Immunology Role of micrornas in successful aging Abruzzo Biomedical Biology of Development and Aging Use of phages as decontamination agents in the production of traditional Italian food: evaluation of effectiveness and possible risk for the consumer IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 20 welfare Guidelines for Health Impact Assessment Emilia Romagna Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Biomedical Cell Biology The new biotechnologies 20 Pagina 169 di 231

170 Gastrointestinal Tract Permeability and Inflammation in HIV Infected patients with mild to moderate Chronic Kidney Disease: a cross over, double blind, randomized clinical trial Emilia Romagna Biomedical AIDS and Related Research Improvement of diagnosis and immunotherapy appropriateness in mould allergic patients by characterization and standardization of mould allergenic extract. ISS Biomedical Immunology Diseases of environmental 20 origin, with reference also to the workplace Mechanism of inhibition and reversion of omega 3 Polyunsaturated Fatty Acids on the growth of intestinal polyps in APC Min/+ mice DE BELLIS Biomedical Oncology 1 Basic Translational Oncology IMMUNOCARRIER DEVELOPMENT AND VALIDATION STUDY FOR TARGETED IMAGING/DRUGDELIVERY IN CANCER THERAPY SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology Abnormalities in T lymphocyte subsets and phagocytes in Cutaneous T cell Lymphomas (CTCL): potential mechanisms driving immunodeficiency and increased susceptibility to infections. Piemonte Biomedical Immunology Improving clinical pathways of patients candidated to cardiac surgery by process modeling MONZINO Clinical Healthcare Delivery and Methodologies 20 Pagina 170 di 231

171 Identification of novel markers of disease through the analysis of the role and impact of mesenchymal stem cells and of mirna/mrna network on the progression of bicuspid aortic valve related aortopathy Campania Biomedical Cardiovascular and Respiratory Changing professional behaviors and measuring the quality of acute stroke care CASA SOLLIEVO SOFFERENZA Biomedical Healthcare Delivery and Methodologies Papillary Thyroid Cancer gender disparity: is the estrogen cancerogenesis related to stemness factors? Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Oncology Clinical relevance of biomarkers involved in EGFR signalling pathway in the outcome of KRAS wild type colorectal cancer patients treated with cetuximab based therapy Campania Clinical Oncology 2 Translational Clinical Oncology SARCOGLYCANS: SIGNALLING FUNCTION IN DIFFERENT CELLULAR COMPARTMENTS AND POSSIBLE ROLE INGENETIC THERAPIES. NEUROLESI Biomedical Genes, Genomes and Genetics The new biotechnologies The role of the airways microbiome in the development of chronic lung infections in CF patients and implications for personalized antibiotic interventions Provincia autonoma Trento Biomedical Infectious Diseases and Microbiology Producing ips cells: a biobank service for translational genetic research Liguria Biomedical Genes, Genomes and Genetics The new biotechnologies 20 Pagina 171 di 231

172 Gender and age related differences in motility and permeability responses in human colon: role of muscarinic receptors DE BELLIS Biomedical Digestive, Kidney and Urological Systems ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES Campania Clinical Genes, Genomes and Genetics Oncology Impact of early extracorporeal photopheresis (ECP) on the management of acute Graft versus host disease (agvhd): clinical, biological and economical implications Friuli Venezia Giulia Clinical Immunology The new biotechnologies Molecular diagnosis of thyroid nodules: evaluation of candidate microrna in fineneedle aspiration biopsy samples and use of circulating microrna as potential biomarkers to differentiate malignant from benign undetermined nodules. Toscana Biomedical Oncology 2 Translational Clinical Oncology Safety and nutritional adequacy of donkey's milk in treating cow's milk allergic children Piemonte Clinical Immunology Food safety and animal 20 welfare Potential health and environmental risks associated to air pollutants in the petrochemical site of Basilicata Basilicata Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Novel molecular mechanisms in pathogenesis of Male Breast Cancer (MBC) Sicilia Biomedical Genes, Genomes and Genetics Oncology 20 Pagina 172 di 231

173 Detection of thyroid cancer biomarkers by SEREX: development of a new diagnostic assay and identification of targets for immunotherapy. Campania Biomedical Oncology 2 Translational Clinical Oncology Assessment of cancer risk behaviours of immigrant population in Italy and the impact in the socio sanitary context. Strategies for a conscious prevention. PASCALE Clinical Risk, Prevention and Health Behavior Oncology Endocrine metabolic pattern and Mediterranean Diet biomarkers in the occurrence of breast cancer relapses IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology In vitro and in vivo antimicrobial activities of innovative and unconventional drug combinations to treat infections caused by multi drug resistant (MDR), extensivelydrug resistant (XDR) or pandrug resistant (PDR) Acinetobacter baumannii and Pseudomonas Campania Biomedical Infectious Diseases and Microbiology From microgist to overt GIST: dissection of the molecular alterations underlying GIST malignant evolution C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 20, Role of HIV 1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies ISS Biomedical AIDS and Related Research Oncology 20,25 Pagina 173 di 231

174 Effect of cognitive stimulation with computerized training (Rehacom) on cerebral metabolism evaluated by 18F FDG PET in patients with mild cognitive impairment (MCI) Liguria Clinical Integrative, Functional, and Cognitive 20, A a case control record linkage study on occupational aspects of neurological diseases ISS Biomedical Brain Disorders and Clinical 20, Estrogen, inflammation and cholesterol homeostasis: a "Bermuda Triangle" for CVD risk? Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 20, Discovery and validation of clinical biomarkers for lung neuroendocrine neoplasms from formalin fixed paraffinembedded tissues Sardegna Biomedical Oncology 2 Translational Clinical Oncology 20, Mediterranean diet and gut microbiota: an operational agorithm to unveil food effects on healthy growth and disease control OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Food safety and animal welfare 20, Ranking patient oriented outcome measures with evidence based criteria in brain tumor patients Veneto Clinical Oncology 2 Translational Clinical Oncology 20, Arterial and Venous thrombotic risk in women approaching ART procedures: evaluation of thrombophilia screening. A prospective cohort study. CASA SOLLIEVO SOFFERENZA Biomedical Healthcare Delivery and Methodologies 20,5 Pagina 174 di 231

175 Treatment of extremely high lipoprotein(a) levels with LDL apheresis in young patients with documented : a proof of concept trial Toscana Clinical Cardiovascular and Respiratory 20, Occupational health risk in dynamic olfactometry. Risk assessment for workers in the olfactometric laboratory and establishment of safety procedures for the implementation of the European Standard method for determination of odour concentration. MAUGERI Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 20, MicroRNA detections in Exhaled Breath Condensate and blood of Malignant Mesothelioma Patients and Healthy Subjects exposed to Asbestos. MAGGIORE Biomedical Oncology 1 Basic Translational Diseases of environmental 20,5 origin, with reference also to the workplace Role of angiotensin converting enzyme inhibitors on cardioprotection against anticancer therapy induced cardiotoxicity: in vivo clinical evidences along with in vitro studies. I.E.O. Clinical Oncology 2 Translational Clinical Oncology 20, Cost effectiveness of Transcatheter Aortic Vale Implantation in high risk patients with severe aortic valve stenosis: a real world study in the Italian public health care system Piemonte Clinical Healthcare Delivery and Methodologies 20, Growth factors and lipid mediators signalling: shared intracellular pathways regulating the complex and dynamic process of wound healing SAN GALLICANO Biomedical Cell Biology 20,5 Pagina 175 di 231

176 Prediction of childhood visceral adiposity and hypertension by body composition measurement in early life in premature and small for gestational age infants. BURLO GAROFALO Clinical Endocrinology, Metabolism, Nutrition and Reproductive 20, STRATEGIES FOR THE CONTROL OF SKIN INFECTIONS BY DRUG RESISTANT BACTERIA WITH NATURAL PRODUCTS. ISS Biomedical Infectious Diseases and Microbiology 20, Human oncogenic risk from consumption of beef red meat CROB Biomedical Oncology 1 Basic Translational Food safety and animal 20,5 welfare Mechanisms underlying cognitive dysfunction and decline in Parkinson's disease and related disorders: brain damage, functional reorganization, and effects of BDNF polymorphisms. DON GNOCCHI Biomedical Brain Disorders and Clinical 20, STRATEGIES TO DECREASE THE INCIDENCE OF INFECTIONS/COLONIZATIONS BY GRAM NEGATIVE MULTIDRUG RESISTANT BACTERIA IN INTENSIVE CARE UNITS. A PROSPECTIVE, MULTICENTER TRANDOMIZED STUDY. Emilia Romagna Clinical Infectious Diseases and Microbiology 20, Role of Prostanoid Metabolism in Aortic Valve Calcification Veneto Biomedical Vascular and Hematology 20, Phenotyping Cheyne Stokes respiration in heart failure patients: a first step towards effective individualized treatment MAUGERI Biomedical Cardiovascular and Respiratory 20,5 Pagina 176 di 231

177 Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of the associated carcinogenic risk. ISS Biomedical Oncology 1 Basic Translational Oncology 20, Antibody deficiency disorders as risk factors for gastric cancer Emilia Romagna Clinical Immunology Oncology 20, Development and validation of a predictive model of mortality and hospitalization in patients with diabetes using administrative databases. Puglia Clinical Endocrinology, Metabolism, Nutrition and Reproductive 20, Influence of adipose derived mesenchymal stem cells and adipocytes on residual cancer cells growth in tumor bed. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology 20, Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 20, Dissecting SOX2 role in breast cancer progression: from the epithelial tomesenchymal transition to metastasis onset PASCALE Biomedical Oncology 1 Basic Translational Oncology 20, Proposal of a methodological procedure for animal biomonitoring in contaminated areas IZS Lazio e della Toscana Biomedical Veterinary Food safety and animal 20,5 welfare Pagina 177 di 231

178 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility n Italian and Sudanese populations. MEDEA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 20, Relationship between 3D BCR structure, microenvironment and response to BCR inhibitors/4hpr, to design novel Chronic Lymphocytic Leukemia combination therapies. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology 20, Human Cardiac Stem Cell Therapy in Patients with Severe Heart Failure Undergoing LVAD Implantation. Lazio Biomedical Cardiovascular and Respiratory mirnas role in Longevity and their relation to cancer survival Sardegna Biomedical Biology of Development and Aging Oncology AN EXTENSIVE STUDY ON EVOLUTION AND PROGNOSIS IN MONOCLONAL GAMMOPATHIES: THE ROLE OF IMMUNOPHENOTYPE, CYTOGENETICS AND HLC RATIO IN PC AND Pre PC SUBCLONAL COMPARTMENTS Piemonte Biomedical Oncology 2 Translational Clinical Oncology GENOMIC AND PROTEOMIC STUDIES ON EARLY STAGE PULMONARY ADENOCARCINOMA: identification of pathogenesis markers relevant for cancer screening and personalized therapy. Abruzzo Biomedical Healthcare Delivery and Methodologies Oncology 21 Pagina 178 di 231

179 Human infection from exposure to norovirus (NoV): improving and harmonization of diagnostic techniques, correlation between clinical cases and contaminated food and assessment of doseresponse IZS Venezie Biomedical Infectious Diseases and Microbiology Food safety and animal welfare Neuroendocrine storm and postoperative depression in cardiac surgery Toscana Clinical Cardiovascular and Respiratory A new scenario for ALS/FTD: genetic contribution in outlier phenotypes AOU San Martino IST Genova Biomedical Genes, Genomes and Genetics Project Title: Respiratory viral infections: evaluation of the clinical value of virological diagnosis and study of the role of innate immune response in determining increased severity SPALLANZANI Biomedical Infectious Diseases and Microbiology New strategies for the eradication of HIV reservoirs Emilia Romagna Biomedical AIDS and Related Research Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Clinical Brain Disorders and Clinical Implementation of a next generation multigene test for prognostic stratification and tailored therapy in glioblastoma patients Emilia Romagna Biomedical Oncology 2 Translational Clinical Oncology 21 Pagina 179 di 231

180 MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Biomedical Oncology 1 Basic Translational Oncology Identification and validation of new molecular targets in the treatment of EGFRresistant NSCLC Campania Biomedical Oncology 2 Translational Clinical Oncology New pathobiologic prognostic factors in colorectal cancers: the role of circulating tumor cells, mismatch repair system's competence, and tumor deposits in non metastatic rectal cancer. IST.TUMORI MILANO Clinical Digestive, Kidney and Urological Systems Oncology CHEMOPREVENTIVE EFFICACY OF GREEN TEA EXTRACTS IN PROSTATE CANCER PROGRESSION. CLINICAL AND MOLECULAR STUDY ON MECHANISM OF ACTION SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology Study of motor cortex electrical activity and neuroinflammatory hypothesis in ALS. SANTA LUCIA Biomedical Brain Disorders and Clinical Omic and biosensor new approaches to detect hormonal growth promoters in foodproducing animals IZS Mezzogiorno Biomedical Genes, Genomes and Genetics Food safety and animal 21 welfare The role of Integrin alpha5/beta1 as a potential therapeutic target in breast cancer bone metastasis Lazio Biomedical Oncology 2 Translational Clinical Oncology 21 Pagina 180 di 231

181 INTERACTION OF ACUTE MYELOID LEUKEMIA CELLS WITH NATURAL KILLER CELLS: BIOLOGICAL ASPECTS AND CLINICAL IMPLICATIONS Emilia Romagna Biomedical Oncology 2 Translational Clinical Oncology Study of genetic variability of HCV genotype 4 strains circulating in Lazio and analysis of their resistance pattern correlated to new DDA drug SPALLANZANI Biomedical Infectious Diseases and Microbiology Development of novel 'tailored' therapy in acute myeloid leukemia (AML) with NPM1 gene mutations Umbria Biomedical Oncology 2 Translational Clinical Oncology Discovery and validation of circulating biomarkers for the early diagnosis, assessment of prognosis and response to treatments in primary liver tumors on cirrhosis Emilia Romagna Biomedical Oncology 2 Translational Clinical Oncology Focus on incidence and diversity of intestinal methanogens and host gut microbiota metabolic interactions in healthy and diseased human groups. Piemonte Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Surveillance on the use of oral anticoagulant drugs in patients with atrial fibrillation MAGGIORE Clinical Vascular and Hematology 21 Pagina 181 di 231

182 Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedulein patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Transcranial Direct Current Stimulation combined with Speech Therapy in Acute and Chronic Post stroke Aphasic Patients: a double blind, sham controlled, randomized study Emilia Romagna Clinical Brain Disorders and Clinical Potential relevance of non classical human leukocyte antigens (HLA) G and E and gelatinases as markers of tumor invasion and progression and their association with Computed Tomography and Magnetic Resonance Imaging perfusion findings in patients with hig Emilia Romagna Clinical Brain Disorders and Clinical GENOMIC CHARACTERISTICS OF REGULATORY T CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA: RELATIONSHIP TO CLINICAL OUTCOME AND POTENTIAL IMPLICATION FOR TREATMENT CROB Clinical Oncology 2 Translational Clinical Oncology A role for the modulation of Rho GTPase signalling in the therapy of Fragile X syndrome ISS Biomedical Brain Disorders and Clinical Striatal cholinergic transmission as a target for therapeutic intervention in Tourette Syndrome SANTA LUCIA Biomedical Brain Disorders and Clinical 21 Pagina 182 di 231

183 Inflammatory and oxidative stress biomarkers associated with carotid atherosclerotic disease progression: a multimarker strategy to identify patients at risk of clinical events ISS Biomedical Vascular and Hematology Decisions of health care management and cost accounting in and Severe Acquired Brain Damage (SABD) NEUROLESI Clinical Healthcare Delivery and Methodologies Genome wide association study and heritability of recently proposed cardiovascular risk factors such as arterial stiffness, endothelial dysfunction, blood pressure variability and pulse pressure amplification in an isolated population living in Ogliastra AUXOLOGICO Biomedical Cardiovascular and Respiratory Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Emilia Romagna Biomedical Immunology Dysglicemia in hypertensive and normotensive adult and old subjects: role of glucocorticoids and Metallothioneins. From pathophysiology to cardiovascular risk prevention. Acronym: DYGAM AGE I.N.R.C.A. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Analytical and clinical validation of assays for PARP1/PAR related biomarkers. ONCOLOGICO DI BARI Biomedical Oncology 2 Translational Clinical Oncology Continuity of care and health expenditure for children with complex needs or chronic health conditions Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology 21 Pagina 183 di 231

184 Proposal of an animal platform for assessing the tumoral cell response to anti angiogenic or cytotoxix antineoplastic agents based on multimodality molecular imaging: multiparametric assessment by optical imaging, micromagnetic Resonance Imaging, and micr Friuli Venezia Giulia Biomedical Oncology 2 Translational Clinical Oncology Keratoconus and autoimmune thyroid disorders HUMANITAS Clinical Brain Disorders and Clinical 21, Identification and comparison of stool and plasma microrna signatures as colorectal cancer markers Piemonte Biomedical Oncology 1 Basic Translational Oncology 21, Modulation of treatment of elderly patients with Diffuse Large B cell Lymphoma guided by Comprehensive Geriatric Assessment combined with metabolomic investigations to identify specific patients frailty profiles predictive of treatment toxicity C.R.O. AVIANO Clinical Oncology 2 Translational Clinical Oncology 21, Development and standardization of biosensor based assays for the fast and sensitive detection of food borne bacteria in food IZS Mezzogiorno Biomedical Bioengineering and Technologies Food safety and animal welfare 21, Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study ISS Clinical Musculoskeletal, Oral and Skin 21,5 Pagina 184 di 231

185 Effectiveness and costs effectiveness analysis of a caring model for hospitalized cancer patients with severe acute clinical problems Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology 21, Non invasive treatment of facet joint osteoarthritis low back pain by Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS): techniques and protocols optimization, clinical study and immune response assessment Sicilia Clinical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 21, ICT for Quality Assurance and Advanced Information Management in Immunology and Oncology Biobanking: a Bridge Between Care and Research HUMANITAS Clinical Healthcare Delivery and Methodologies 21, Activation Induced Cytidine Deaminase as Oncogenic Mutator in HCV related B cell Non Hodgkin s Lymphoma and Hepatocellular Carcinoma: A Single Celllevel Study. Puglia Biomedical Oncology 1 Basic Translational Oncology 21, Study on the interaction of polyomavirus JC (JCPyV) with stem cells derived lineages Toscana Biomedical Infectious Diseases and Microbiology 21, Functional Immune Reconstitution Evaluation of Immune Senescence Process in HIV Mono infected and Co infected Patients Undergoing cart (FIRE Study) SPALLANZANI Biomedical AIDS and Related Research 21, Coronary Arteriogenesis with combined Heparin and EXercise therapy in Chronic refractory Angina (CARHEXA study) Toscana Clinical Cardiovascular and Respiratory 21,5 Pagina 185 di 231

186 IMPACT OF COMPUTERIZED PRESCRIPTION ON COMPLIANCE WITH GUIDELINES RECOMMENDED PROCESS IN PNEUMONIA. A STUDY TO ANALYZE A BETTER CONTROL OF ANTIBIOTIC THERAPY. Emilia Romagna Clinical Healthcare Delivery and Methodologies 21, Study of the role played by the Na+ Ca2+ exchanger 1 (NCX1) for the development of the cardiac damage to bacterial infections causing hypertrophic heart response Marche Biomedical Cardiovascular and Respiratory 21, Validation of Reticulocalbin 1 (RCN 1) as a new marker for renal cell carcinoma (RCC) in a large retrospective study by IHC and regulation analysis of protein expression. Piemonte Clinical Oncology 2 Translational Clinical Oncology 21, Multiplatform approach to dissect Wilms tumor heterogeneity IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology 21, CANCER IN IMMUNOCOMPROMISED POPULATIONS, HIV INFECTED (HIV) PATIENTS, ORGAN TRASPLANT RECIPIENTS (OTRs) and HIV OTRs: NEW PREVENTIVE and TREATMENT STRATEGIES FOR SOLID TUMOURS C.R.O. AVIANO Clinical Oncology 2 Translational Clinical Oncology 21, Role of hypothermia in organ dysfunction after cardiac arrest Sicilia Biomedical Cardiovascular and Respiratory 21, Risk assessment of patients and medical operators in diagnostic and therapeutic cancer procedures: clinical, chemical, physical and humanization aspects Sicilia Clinical Healthcare Delivery and Methodologies Oncology 21,5 Pagina 186 di 231

187 Use of amiodarone and derivatives for treatment/prophylaxis of viral hemorragic fevers. Veneto Biomedical Infectious Diseases and Microbiology 21, Analysis of cardiomyopathies and arrhythmogenic syndromes associated with high risk of sudden death: an integrated approach of functional genomics and clinical instrumental parameters. Puglia Biomedical Cardiovascular and Respiratory The new biotechnologies 21, Prognostic and predictive potential of mirna signatures linking cancer to inflammatory and fibrotic diseases SAN MATTEO Biomedical Oncology 1 Basic Translational Oncology 21, Early detection of neurodegenerative diseases. The case of Alzheimer's disease Liguria Biomedical Brain Disorders and Clinical 21, Development of innovative methods for radiobiological optimization of molecular radiotherapy treatments I.E.O. Clinical Bioengineering and Technologies The new biotechnologies 21, INNOVATIVE THERAPY FOR OSTEOARTHRITIS: FROM CLASSICAL VISCOINDUCTION TO INTRA ARTICULAR INFILTRATION OF MULTILAYERED HYALURONIC ACID AND CHITOSAN MICROCAPSULES FOR PRECISE POINT OF CARE DELIVERY AND CONTROLLED RELEASE PROFILE Lazio Clinical Bioengineering and Technologies The new biotechnologies 21, Comprehensive evaluation of the potential of engineered nanoparticles to induce bronchial hyperreactivity in exposed workers. Lazio Biomedical Bioengineering and Technologies Diseases of environmental origin, with reference also to the workplace 21,5 Pagina 187 di 231

188 MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEEN EARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. THE EARLY STUDY. Piemonte Clinical Cardiovascular and Respiratory 21, Enabling assessment of attention and motivation during post stroke robotassisted rehabilitation to improve patient adherence to treatment and outcome. MAUGERI Clinical Musculoskeletal, Oral and Skin 21, Development of a cheap point of care assay for molecular diagnosis of legionellosis ISS Biomedical Infectious Diseases and Microbiology 21, Nanotechnology for the delivery of Zoledronic Acid: a new opportunity against cancer REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology 21, Safety of general anaesthesia (GA) in neonatal and pediatric age: neurotoxicity of drugs as revealed by neuropsychological indexes and biomarkers Emilia Romagna Clinical Brain Disorders and Clinical 21, QOLIBRI Quality of Life after Brain Injury: the new challenge for tomorrow SANTA LUCIA Biomedical Risk, Prevention and Health Behavior 21, Role of bilateral STN DBS on impulse control disorders and related behaviors in Parkinson's disease: a quasi experimental clinical trial CARLO BESTA Clinical Brain Disorders and Clinical 21,75 Pagina 188 di 231

189 Antibiotic resistant bacteria and ready to eat salads: are they really ready to be consumed? IZS Mezzogiorno Biomedical Veterinary Food safety and animal 21,75 welfare Measured physiological and psycological outcomes with hypnotic behavioral adjuncts as an experimental tool in laboratories of interventional cardiac procedures Piemonte Clinical Biobehavioral and Behavioral Processes 21, biomarkers characterization in the glatiramer acetate therapy of relapsing multiple sclerosis Puglia Biomedical Emerging Technologies and Training in s 21, Cyclodextrin cross linking nanosponges (CD NS) for melanoma targeted drug delivery Piemonte Biomedical Bioengineering and Technologies The new biotechnologies Antimicrobial peptide based nanotherapeutics to prevent biofilm formation or to eradicate pre formed biofilms associated with catheter related, antibiotic resistant nosocomial infections Toscana Biomedical Bioengineering and Technologies Genetic, molecular and bioinformatics approaches for early detection of HIVassociated neurocognitive disorders (BioHAND Study) Puglia Biomedical Brain Disorders and Clinical The subcutaneous immunoglobulins as firstline therapy of chronic inflammatory neuropathies. A pilot study. Piemonte Clinical Brain Disorders and Clinical 22 Pagina 189 di 231

190 Innovative Nanomedicines for the Efficacious Treatment of Dogs affected by Leishmaniasis IZS Sicilia Biomedical Veterinary Food safety and animal 22 welfare CANCER RISK EVALUATION IN A COHORT OF FARMERS EXPOSED TO ZOONOTIC AGENTS IZS Sicilia Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Clinical and Economical Impact of a Multiplex PCR Based Assay for a rapid Detection of Pathogens Causing Sepsis in non hospitalized onco hematological Patients with neutropenic fever SAN RAFFAELE Milano Clinical Infectious Diseases and Microbiology Point of care lung ultrasonography in the bedside evaluation of patients in the critical care and emergency settings Piemonte Clinical Cardiovascular and Respiratory The new biotechnologies Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at deliveryto identify gene or protein alterations predisposing the newborn to obesity. SDN Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Strategies To Improve Human Cardiac Stem Cell Regenerative Capacity In Patients With Post Ischemic Left Ventricular Remodelling Lazio Biomedical Cardiovascular and Respiratory Genetic, immunologic and viral determinants of HIV 1 disease progression Lombardia Biomedical AIDS and Related Research 22 Pagina 190 di 231

191 Nanomaterials based diagnostic devices for melanoma I.E.O. Clinical Bioengineering and Technologies Oncology Cerebral blood flow velocity in children with sickle cell disease before and after adenotonsillectomy Emilia Romagna Clinical Cardiovascular and Respiratory CHILDHOOD HISTIOCYTOSES: FROM PATHOGENESIS TO TARGET THERAPY "HISTIOCARE" Toscana Biomedical Immunology Inflammatory bowel diseases and environmental stressors: a system biology approach Campania Biomedical Digestive, Kidney and Urological Systems Diseases of environmental origin, with reference also to the workplace EFFECTS OF PERIPHERALLY ADMINISTERED BDNF IN THE R6/2 MOUSE MODEL OF HUNTINGTON S DISEASE SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Humanization of Emergency Departments in Hospitals: new features and patient satisfaction for chronic metabolic and s Piemonte Clinical Healthcare Delivery and Methodologies Role of deubiquitinases in resistance to treatment of ovarian carcinoma IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology Search for cancer specific proteomic biomarkers in exosomes and red blood cells to rule out lung cancer risk in suspicious incidental nodules detected by imaging techniques Veneto Biomedical Oncology 2 Translational Clinical Oncology 22 Pagina 191 di 231

192 IDENTIFICATION OF NEW STRAINS OF POTENTIALLY PROBIOTIC BACTERIA FROM HUMAN FECES AND FOODS: SUBSEQUENT INVESTIGATION OF THEIR ACTIVITY ON THE BROKERS OF THE SYSTEMIC AND INNATE IMMUNE SYSTEM. POSSIBLE USE OF THE ISOLATE STRAINS ALSO AS DELIVERY SYSTEM FOR Emilia Romagna Biomedical Immunology Realization of a database of clinical data for improving the outcome of the univentricular heart patient ISS Biomedical Cardiovascular and Respiratory Prematurity and low weight at birth as new conditions predisposing to an increased cardiovascular risk. A human study by means of metabolomics, instrumental cardiology, endothelial progenitor cells evaluation, paralleled by an animal experimental model. Sardegna Clinical Cardiovascular and Respiratory Role of CREB protein family members in human lymphoid malignancies Abruzzo Biomedical Cell Biology Oncology Maternal exposure to ENMs: a comprehensive study of feto placental effects as a function of developmental stage. Lazio Biomedical Bioengineering and Technologies Diseases of environmental origin, with reference also to the workplace 22, Molecular determinants of malignancy, invasiveness and response to therapy of Oro pharyngeal squamous cell carcinomas. A molecular and Redox proteomics compaative analysis of HPV positive and HPV negative invasive tumours. REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology 22,25 Pagina 192 di 231

193 Restoring innate immunity by in vivo gene editing: Development of novel approaches to correct abnormal cilia motility in the respiratory airways and cure the primary ciliary dyskinesia in pediatric patients Toscana Biomedical Genes, Genomes and Genetics 22, SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) BASED DIAGNOSTIC KIT DEVELOPMENT FOR LEUKEMIA BIOMARKER DETECTION SAN RAFFAELE Milano Biomedical Bioengineering and Technologies The new biotechnologies 22, A MULTIMODALITY APPROACH TO PREVENT POSTOPERATIVE NEUROLOGICAL DYSFUNCTION IN PATIENTS UNDERGOING CARDIAC SURGERY Veneto Clinical Brain Disorders and Clinical 22, Identification of molecular signature in thyroid carcinoma to improve Fine Needle Aspiration Biopsy Accuracy Sicilia Biomedical Oncology 2 Translational Clinical Oncology 22, Influence of Zinc transporters on glycemic control and cardiovascular risk prevention I.N.R.C.A. Clinical Endocrinology, Metabolism, Nutrition and Reproductive 22, Creation and Preclinical validation of stem cell functionalized bio substitutes for oral bone defects treatment Piemonte Biomedical Bioengineering and Technologies The new biotechnologies 22, Renal stress Echo: a new non invasive non ionizing imaging tool to assess renal sympathetic activity in arterial hypertension and cardiometabolic disease Toscana Clinical Cardiovascular and Respiratory 22,5 Pagina 193 di 231

194 Role of maternal intrapartum antibiotic prophylaxis on neonatal gut microbiota flora and onset of later allergy related diseases Lombardia Biomedical Immunology 22, Process modelling as a tool to support integrated care pathway implementation in lung cancerpatients. Friuli Venezia Giulia Clinical Healthcare Delivery and Methodologies Oncology 22, Cardiopulmonary risk and Transplantation Campania Clinical Cardiovascular and Respiratory 22, Study of orphan muscle diseases with an inflammatory component and identification of novel therapeutic molecules. SAN RAFFAELE Milano Biomedical Musculoskeletal, Oral and Skin 22, Regulatory and effector T cell populations count during chronic graft versus host disease and extracorporeal photopheresis (ECP): flow cytometric cgvhd activity monitoring. Lazio Clinical Immunology Oncology 22, A mathematical experimental model of beta amyloid diffusion in Alzheimer disease and its application to early diagnosis ARCISPEDALE Reggio Emilia Clinical Brain Disorders and Clinical 22, Identification of biological markers as predictors of brain plasticity and indicators of the efficacy of rehabilitation in poststroke patients AUXOLOGICO Biomedical Brain Disorders and Clinical 22,5 Pagina 194 di 231

195 Epithelial ovarian cancer: management of advanced stage disease recurrence by an (epi)genomic driven approach IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology 22, Characterization of the microbiome of natural and invasive vector mosquito populations through next generation sequencing IZS Venezie Biomedical Infectious Diseases and Microbiology The new biotechnologies 22, SEEKING MOLECULAR BIOMARKERS OF CERVICAL INTRAEPITHELIAL NEOPLASIA PROGRESSION BY MICROARRAY ANALYSIS OF CLONAL CIN3 KERATINOCYTES. Emilia Romagna Biomedical Oncology 2 Translational Clinical The new biotechnologies 22, Health Care Professionals as Second Victims After Adverse Events Marche Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 22, NEW ANTIFUNGAL THERAPEUTIC STRATEGIES IN NANOMEDICINE ISS Biomedical Infectious Diseases and Microbiology 22, INNOVATIVE EPINEPHRINE (ADRENALINE) FORMULATIONS WITH IMPROVED STABILITY FOR USE IN EMERGENCY SITUATIONS SAN MATTEO Biomedical Cardiovascular and Respiratory 22, MicroRNA profile in plasma and sputum in the low dose CT lung cancer screening trial Italung Toscana Biomedical Oncology 2 Translational Clinical Oncology 22, Health and Economic Impact of Tobacco Control Policies in Italy Toscana Biomedical Risk, Prevention and Health Behavior Oncology 22,5 Pagina 195 di 231

196 Evaluation of potential presence of heavy metals and nanoparticles in fishes and baby foods IZS Sicilia Biomedical Risk, Prevention and Health Behavior Food safety and animal welfare 22, Development of a Regional network for the improvement of the operators compliance to the management of the Italian Register of Oncologic Drugs (RFOM) of Italian Medicines Agency (AIFA) Toscana Clinical Healthcare Delivery and Methodologies Oncology 22, Evaluation of the molecular mechanisms and therapeutic efficacy of a new NGF mimetic compound with anti apoptotic activity in cardiac and cerebral ischemia/reperfusion (I/R) Toscana Biomedical Brain Disorders and Clinical 22, ACG4GEO: Integration between "Adjusted Clinical Group" system and Geomedicine for a new vision about the environment health and personal health Veneto Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 22, Clinical and genetic study of the predisposition to Renal Cancer in women affected by uterine fibroids and families with Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome Lazio Clinical Oncology 2 Translational Clinical Oncology 22, Age immunological profile of stable kidney allograft patients as a key to modulate the immunosuppressive therapy Piemonte Clinical Immunology 22,5 Pagina 196 di 231

197 Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolylhydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy MAUGERI Biomedical Digestive, Kidney and Urological Systems The new biotechnologies 22, Attention to memory: mechanisms of competition during memory retrieval in mild cognitive impairment SANTA LUCIA Clinical Integrative, Functional, and Cognitive 22, IDENTIFICATION OF THE GENETIC BACKGROUND ASSOCIATED TO THE IMPAIRMENT OF RENAL TUBULAR INTRACELLULAR MACHINERY FOR ENDOCYTOSED PROTEINS. SELECTION OF NOVEL BIOMARKERS PREDICTING ONSET OR PRGRESSION OF CHRONIC RENAL FAILURE. Veneto Biomedical Genes, Genomes and Genetics The new biotechnologies 22, Economic Impact of Target Agents and their Side Effects Piemonte Biomedical Oncology 2 Translational Clinical Oncology 22, Physical Activity prevents the Cognitive Impairment in the Metabolic Syndrome (PACIMeS) SANTA LUCIA Biomedical Risk, Prevention and Health Behavior Multidisciplinary Intervention Protocol in metabolic emergencies in Anorexia Nervosa Emilia Romagna Clinical Healthcare Delivery and Methodologies Prospective study of molecular prognostic and predictive factors and pharmacokinetic analysis in patients with Gastrointestinal Stromal Tumor treated with targhet therapy Toscana Clinical Oncology 2 Translational Clinical Oncology 23 Pagina 197 di 231

198 Molecular profiling of adult Acute Lymphoblastic Leukemia for risk stratification and treatment definition Lombardia Clinical Oncology 2 Translational Clinical Oncology Ectopic calcifications: from molecular mechanisms towards therapeutic perspectives Emilia Romagna Biomedical Vascular and Hematology Impact of early high dose atorvastatin versus rosuvastatin on Contrast Induced Acute Kidney Injury in unselected patients with non ST elevation acute coronary syndromes scheduled for early invasive strategy Toscana Clinical Cardiovascular and Respiratory The impact of the Directive 2010/63/EU on Italian research activities and welfare of animals ISS Biomedical Veterinary Food safety and animal 23 welfare Gender effect on the pleiotropic actions of statins on lipoproteins and platelets from elderly women affected by Type 2 diabetes mellitus I.N.R.C.A. Biomedical Vascular and Hematology Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment ofthe neurocognitive and clinical outcomes of premature newborns SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Disability diseases related: (Di.di.re) ICF as tools to weight disability in rehabilitation SAN RAFFAELE Pisana Roma Clinical Healthcare Delivery and Methodologies 23 Pagina 198 di 231

199 Empower through Communication: a Generative Model for Health Care Organizations NEUROLESI Clinical Healthcare Delivery and Methodologies Biological and therapeutical significance of androgen receptor expression in salivary gland cancers (SGCs): a translation research in a randomized, international, phase II study to evaluate the efficacy of chemotherapy versus androgen deprivation therapy IST.TUMORI MILANO Clinical Oncology 2 Translational Clinical Oncology Improving reading and behavioural control in dyslexia and ADHD with training on executive functions OSPEDALE BAMBINO GESU' Clinical Biobehavioral and Behavioral Processes Optimal duration of treatment and optimal management of thromboembolic events in cancer patients (Morgagni Cancer Study) ARCISPEDALE Reggio Emilia Clinical Vascular and Hematology Oncology Sexual function in epileptic male patients NEUROLESI Clinical Brain Disorders and Clinical Novel Clinical and Molecular Determinants of Glucocorticoid Response in Obesityrelated Asthma Campania Biomedical Cardiovascular and Respiratory Development of a model for quantitative risk assessment of tick borne diseases in Italian urban parks ISS Biomedical Infectious Diseases and Microbiology Ethics in Cancer Care: a new service I.E.O. Clinical Healthcare Delivery and Methodologies Oncology 23 Pagina 199 di 231

200 Pregnancy complication in transplanted women: anti phospholipids antibodies as sensitive biomarkers of prognostic value and pathogenetic determinants. ISS Clinical Endocrinology, Metabolism, Nutrition and Reproductive Hypoxia and MicroRNAs in the Regulation of the Dystrophin associated Protein Complex: Implications for Cognitive Deficits in Duchenne Muscular Dystrophy ISS Biomedical Molecular, Cellular, and Developmental 23, Update, integration and implementation of the Italian Respiratory Risk Charts Toscana Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 23, Clinical and genetic new tools for Autosomal Dominant Polycystic Kidney Disease diagnosis Emilia Romagna Clinical Digestive, Kidney and Urological Systems The new biotechnologies 23, Identification and validation of biomarkers in saliva and scraping of buccal cells for the early detection of oral lesions at risk of developing cancer Veneto Biomedical Oncology 2 Translational Clinical Oncology 23, Identification of immune correlates of clinical activity and/or disease outcome in melanoma and mesothelioma patients undergoing immunotherapy or targeted therapy Toscana Clinical Oncology 2 Translational Clinical Oncology 23, STUDY ON THE POTENTIAL USE OF COMBRETUM MICRANTHUM AS AN ANTITUMOR AND CHEMOPREVENTIVE AGENT. AOU San Martino IST Genova Biomedical Oncology 2 Translational Clinical Oncology 23,5 Pagina 200 di 231

201 Understanding sirtuin specificity and identification of selective therapeutics using a trans kingdom approach IDI Biomedical Genes, Genomes and Genetics 23, Integrated lipidomic profiling in diabetes and in a cohort of subjects in a mediterranean area of southern Italy: a nested case control study DE BELLIS Biomedical Biological Chemistry and Macromolecular Biophysics 23, Development and validation of a personal dosimeter for the exposure to electromagnetic fields of Magnetic Resonance healthcare personnel Toscana Biomedical Bioengineering and Technologies The new biotechnologies 23, Innovative analytical methods for determination of veterinary drug residues in foodstuffs IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 23,5 welfare The Mitochondrial culprit in Amyotrophic Lateral Sclerosis: unravelling a novel molecular pathway to regulate VDAC1 in the disease's etiology SANTA LUCIA Biomedical Brain Disorders and Clinical 23, Improving the prognosis of melanoma patients through the use of new metastatic markers associated to the Notch pathway. Lombardia Biomedical Oncology 1 Basic Translational Oncology 23,5 Pagina 201 di 231

202 Implementation of a network on the use of Human Biomonitoring Data in Environmental Epidemiology (HumanBioEnvEpi: HBEE ITA)Realizzazione di una rete sull uso nell epidemiologia ambientale dei dati del biomonitoraggio umano (HumanBioEnvEpi: HBEE ITA) Piemonte Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace 23, Occupational and environmental exposure to dangerous chemicals and reproductive pathologies Campania Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace 23, Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia Clinical Brain Disorders and Clinical Diseases of environmental origin, with reference also to the workplace 23, The Development and progression of breast cancer: when micrornas fail to inhibit EMT and stemness. C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 23, Work oriented upper extremity functional evaluation: development of an integrated measurement platform for identification of return to work strategies Toscana Clinical Surgical, Biomedical Imaging, and Bioengineering Diseases of environmental origin, with reference also to the workplace 23, Telemonitoring in long term ventilatordependent patients: a multicenter randomized controlled study Toscana Clinical Cardiovascular and Respiratory 23, Extracorporeal Shock Waves (ESW) as a tool in stem cell based procedures for cartilage and tendon regeneration Piemonte Biomedical Bioengineering and Technologies The new biotechnologies 23,5 Pagina 202 di 231

203 Identification and use of markers of exposure and effect on decision making in patients with metal on metal joint implants RIZZOLI Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 23, Ex vivo studies on hyperhomocysteinemiainduced epigenetic modifications as potential biomarkers for early diagnosis of cerebrovascular disorders. Sardegna Biomedical Molecular, Cellular, and Developmental 23, Biomolecular networks contributing to cancer risk in dysmetabolic disorders: implications for type 2 diabetes and obesity SAN RAFFAELE Pisana Roma Biomedical Oncology 2 Translational Clinical 23, Effective and genetically driven bio clinical road map defining tailored, multidisciplinary, treatment strategies of metastatic colorectal cancer (MCRC) patients. Abruzzo Biomedical Oncology 2 Translational Clinical Oncology 23, CHARACTERIZATION OF BIOMARKERS FOR CARDIOVASCULAR DISEASES AT EARLY PRESENTATION Veneto Biomedical Biological Chemistry and Macromolecular Biophysics 23, Identification of novel biomarkers of recurrence in locally advanced cervical cancer REGINA ELENA Clinical Oncology 2 Translational Clinical Oncology Genetic and environmental factors underlying metabolic inflexibility and their impact for the prevention and treatment of obesity: basic and clinical studies ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 24 Pagina 203 di 231

204 GENE EXPRESSION PROFILE AT THE ONSET OF SEVERE CARDIAC FAILURE: IDENTIFICATION AND VALIDATION OF NEW BIOMARKERS GASLINI Biomedical Cardiovascular and Respiratory Angiogenic pattern as early marker of colon cancer progression. A morphological and immunohistochemical study on colorectal adenomas according to modality of detection. Toscana Biomedical Oncology 1 Basic Translational Oncology THE USE OF SENTINEL ANIMALS TO EVALUATE THE ROLE OF ENVIRONMENTAL CHEMICAL POLLUTION IN YOUNG WOMEN WITH BREAST CANCER LIVING IN SINs (NATIONAL interest SITES) IZS Mezzogiorno Biomedical Veterinary Food safety and animal 24 welfare Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese IZS Mezzogiorno Biomedical Veterinary Food safety and animal 24 welfare Viral infections and related neurological and intestinal damages as possible factors triggering autism spectrum disorders Campania Clinical Brain Disorders and Clinical Neuronal lifespan in longer living brains SAN MATTEO Biomedical Biology of Development and Aging 24 Pagina 204 di 231

205 CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG THREE IMPORTANT ACUTE ITALIAN HOSPITALS Toscana Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace Epigenetic modulation by asbestos exposure in asbestos related cancers:identification of epigenetic biomarkers to predict asbestos related malignancies. Marche Biomedical Oncology 2 Translational Clinical Oncology STRATEGIES TO PROMOTE THE CONTINUOUS IMPROVEMENT OF PATIENT SAFETY AND QUALITY IN HEALTH CARE Campania Clinical Healthcare Delivery and Methodologies Ultimate and stable healing of chronic ulcers of the lower limbs with long lasting patient recovery: a great achievement of dramatic social impact with minimal financial commitment. AOU San Martino IST Genova Clinical Musculoskeletal, Oral and Skin HELP (Hepatitis and HIV Emergencies, Life & protection Program for drug addicts and immigrants wide range information) Campania Clinical Infectious Diseases and Microbiology HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy Lombardia Biomedical AIDS and Related Research 24 Pagina 205 di 231

206 Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Toscana Biomedical Oncology 2 Translational Clinical Oncology Novel tools for immune monitoring and immune reconstitution in children with severely compromised T lymphocyte responses associated with hematooncological diseases. OSPEDALE BAMBINO GESU' Clinical Immunology Potential Role of blood mirna as non invasive biomarkers for early detection of stroke and hemorrhagic transformation Sicilia Clinical Brain Disorders and Clinical DEVELOPMENT AND VALIDATION OF A COMORBIDITY INDEX SPECIFIC FOR STROKE PATIENTS Emilia Romagna Clinical Brain Disorders and Clinical ASSESSMENT OF PSYCHO PHYSICAL RESPONSE TO STRESSORS IN WORK ENVIRONMENT. RESEARCH OF CHANGES IN HEALTH PROFESSIONALS AS A RESULT OF PARTICIPATION IN A GROUP EXPERIENCE ON STRESS MANAGEMENT AND INTERPERSONAL COMMUNICATION. I.N.R.C.A. Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace Prescription of Physical Activity to prevent the onset of type 2 diabetes Veneto Clinical Risk, Prevention and Health Behavior 24 Pagina 206 di 231

207 Effectiveness of repeated immunizations with DNA plasmids encoding HER 2/neu in the long term prevention of mammary cancer in HER 2/neu transgenic mice I.N.R.C.A. Biomedical Biology of Development and Aging Oncology A simple set of tools for large scale multiparametric screening of sensory motor functions of the cervico cranial area. A combined longitudinal and cross sectional study in 4 14 years old children Piemonte Biomedical Integrative, Functional, and Cognitive Reduced aspirin action in preventing cardiovascular events in diabetic patients: molecular and cellular studies on megakaryocyte progenitor cells and platelets. ISS Biomedical Vascular and Hematology Risk stratification of hospital acquired infection, an Artificial Neural Network approach Piemonte Clinical Risk, Prevention and Health Behavior Can we predict the cognitive status in mild cognitive impairment (MCI) subjects who had a traumatic brain injury (TBI) basing on neurophysiological and biological markers? SAN RAFFAELE Pisana Roma Clinical Brain Disorders and Clinical 24, Identification of immunologic and vascular biomarkers of disease progression or remission in autoimmune disorders for the clinical management and therapeutic monitoring SAN GALLICANO Clinical Immunology 24,25 Pagina 207 di 231

208 Comprehensive diagnostic and rehabilitation tools in the assessment and treatment of Neglect dyslexia SANTA LUCIA Clinical Brain Disorders and Clinical 24, Biomarkers of effect as novel tools for the identification of PCB contamination in mussels and their impact on human health. IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 24,5 welfare In vivo safety and tolerability of sorghum based gluten free products in coeliac patients Campania Clinical Endocrinology, Metabolism, Nutrition and Reproductive Food safety and animal welfare 24, Early genomic and cellular markers in sporadic colorectal cancer: an integrative methodological approach combining the response of biomarkers in organ biopsies and in a healthy cell system like peripheral mononuclear cells. Toscana Biomedical Genes, Genomes and Genetics Oncology 24, NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F FDG PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT Sicilia Clinical Oncology 2 Translational Clinical Oncology 24, A Randomized Clinical Double Blind Placebo Controlled Study of Human Fecal Microbioma in Irritable Bowel Syndrome Treated with Probiotic and a Boswellia Serrata Gum Extract Tritated in Boswellic Acids Toscana Clinical Digestive, Kidney and Urological Systems 24,5 Pagina 208 di 231

209 Rational and innovative design of immunogens based on HIV 1 clade C Env proteins specifically mutated in glycan moieties for broadly effective vaccine purpose ISS Biomedical AIDS and Related Research 24, Observational population based study on ovarian cancer management within the Piedmont Region Cancer Network Piemonte Clinical Healthcare Delivery and Methodologies Oncology 24, Directing the axonal outgrowth via magnetic nanoparticles and magnetic fields for nerve regeneration: a pre clinical study Toscana Biomedical Molecular, Cellular, and Developmental Lung water assessment by quantitative chest ultrasonography in cardiac surgery patients Emilia Romagna Clinical Cardiovascular and Respiratory Role of mir 494 and other micrornas in Src kinase inhibition of colorectal cancer stem cells Umbria Biomedical Oncology 1 Basic Translational Oncology Role of HDL and endothelial dysfunctions in modulating the impact of risk factors on sub clinical atherosclerosis in diabetes Toscana Clinical Vascular and Hematology Early detection of chronic obstructive pulmonary disease induced by industrial pollutants by analysis of volatile organic compounds from exhaled breath. Puglia Clinical Cardiovascular and Respiratory Diseases of environmental origin, with reference also to the workplace 25 Pagina 209 di 231

210 New ultrasonic methods for OSTEOporosis diagnosis at the proximal FEMur (OSTEOFEM) Puglia Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies Identification of host prion proteins resistant to template conversion into PrPSc IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 25 welfare Immunological and virological monitoring of opportunistic virus infections in systemic lupus erythematosus patients SAN MATTEO Biomedical Immunology Attenuation of the Hippo pathway by praja2 reduce glioblastoma growth NEUROMED Biomedical Oncology 1 Basic Translational Oncology Klebsiella Pneumoniae carbapenemases (KPCs) positive strains in hospitalized decompensated cirrhotic patients: a nationwide epidemiologic survey and the evaluation of a new eradication treatment based on faecal microbiota transplantation Emilia Romagna Clinical Infectious Diseases and Microbiology Genetic and functional analysis for identification of driver pathways of resistance in breast cancer metastases and xenograft obtained from patients with triple negative, HER2 positive and Luminal B subtypes I.E.O. Clinical Oncology 2 Translational Clinical Oncology Efficacy of Etanercept vs Adalimumab in retreating psoriatic patients who previously failed treatment with the same molecule SAN GALLICANO Clinical Musculoskeletal, Oral and Skin 25 Pagina 210 di 231

211 Oxidative stress and microrna 125b: from molecular mechanisms to therapeutic implications in Hailey Haileydisease ISS Biomedical Musculoskeletal, Oral and Skin ECG IN UN CLIK Lazio Clinical Cardiovascular and Respiratory Exploitation of genetically engineered oral carcinoma relapse models for development and pre clinical assessment of targeted combinatorial therapeutic strategies Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology A novel anti CXCR4 drug RFF 1: a Phase I/II Clinical Trial PASCALE Biomedical Oncology 2 Translational Clinical Oncology Combined intravenous and intra arterial thrombolysis for ischemic stroke due to large vessel occlusion: feasibility, safety and effectiveness. AOU San Martino IST Genova Clinical Brain Disorders and Clinical Protein based carriers for targeted photodynamic therapy Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology Identification of mycobacterial cell surface molecules as molecular markers of disease Campania Biomedical Infectious Diseases and Microbiology Prostate cancer: a study on the mechanisms underlying the development of androgenindependence to identify early biomarkers and new therapeutic targets AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Oncology 25 Pagina 211 di 231

212 Cardiovascular disease in intrauterine growth restriction (IUGR). A clinical and proteo metabolomic investigation. Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies Sustainable innovation of husbandry practices to improve animal health and welfare and to reduce the use of antimicrobials in broiler chickens IZS Venezie Biomedical Veterinary Food safety and animal 25 welfare THERAPEUTIC DEVICE OF FOR ADOLESCENTS WITH SEVERE PSYCHIATRIC DISORDERS. INTENSIVE SPECIFIC OUT PATIENT SERVICE Lombardia Clinical Risk, Prevention and Health Behavior 25, Inflammatory links between obesity, asthma and adaptive immunity in childhood ISS Biomedical Immunology 25, Contribution of the different risk factors to the prevalence of gestational diabetes mellitus. A cohort study. Emilia Romagna Clinical Endocrinology, Metabolism, Nutrition and Reproductive 25, Toxic and infective agents as potential cause of congenital malformations of domestic ruminant calves in southern Italy. IZS Mezzogiorno Biomedical Veterinary Diseases of environmental 25,5 origin, with reference also to the workplace Effectiveness of oncology drugs of AIFA Oncology Register AOU San Martino IST Genova Clinical Oncology 2 Translational Clinical Oncology 25,5 Pagina 212 di 231

213 An economic, randomized, prospective phase III trial comparing the combination of anthracycline taxane vs bevacizumabpaclitaxel as first line treatment in women with HER 2 negative metastatic breast cancer REGINA ELENA Clinical Oncology 2 Translational Clinical Oncology 25, Study of the selectivity of botulinum toxins (BoNT A and BoNT C) for muscle fiber type units and their kinetics diffusion by exoendocytosis: electro and impedence myography evaluation, biochemical pathway analysis and possible clinical implication in Sp Toscana Biomedical Molecular, Cellular, and Developmental 25, Genetic Polymorphisms and pain sensitivity in a Sicilian population of oncological patients Sicilia Biomedical Oncology 2 Translational Clinical Oncology 25, Ecological and biomolecular studies on Culicoides for an innovative approach to the control of Culicoides transmitted diseases IZS Sicilia Biomedical Infectious Diseases and Microbiology Diseases of environmental origin, with reference also to the workplace 25, FISH FARMING AND WELFARE: ASSESSMENT OF ACOUSTIC, THERMAL AND CHEMICAL STRESS FOR A MORE AQUACULTURE SUSTAINABLE IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 25,75 welfare Novel clinical applications of autologous adipose derived stem cells. Emilia Romagna Clinical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 26 Pagina 213 di 231

214 Influence of cell cell adhesion molecules expression on the metastatic growth of colon cancer stem cells in liver. ONCOLOGICO DI BARI Biomedical Oncology 1 Basic Translational Oncology ASSISTENTIAL AFTERMATH OF DISTRESS IN MATERNIY WARD PROFESSIONALS FACING MISCARRIAGE, STILLBIRTH AND PERINATAL GRIEF Piemonte Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace ANALYSIS OF ADIPONECTIN SYSTEM AS NEW TARGET FOR DIAGNOSIS AND THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY PATIENTS WITH COEXISTENT CARDIOVASCULAR DISEASE SDN Biomedical Cardiovascular and Respiratory Nanoparticles as drug delivery system for the therapy of Mesothelioma and Pancreatic Cancer. PASCALE Biomedical Oncology 2 Translational Clinical Oncology COCAINE AND CHEST PAIN Emilia Romagna Clinical Risk, Prevention and Health Behavior The anatomical substrate of unilateral neglect subtypes: behavioral and neuroimaging investigation S.CAMILLO Biomedical Brain Disorders and Clinical SURVEILLANCE OF THE PREVALENCE OF PERIODONTITIS AND CHARACTERIZATION OF MICROBIOLOGICAL PROFILE IN A REPRESENTATIVE ADULT ITALIAN POPULATION. SPALLANZANI Biomedical Infectious Diseases and Microbiology 26 Pagina 214 di 231

215 BLeeding Events and Maintenance DoSe of PraSugrel. Toscana Clinical Cardiovascular and Respiratory Functional Imaging and Transcriptomics for Prediction of Ovarian cancer response to Trabectedin ISS Biomedical Oncology 2 Translational Clinical Oncology A GENETIC, CLINICAL AND SOCIAL INVESTIGATION OF DEMENTIA IN NORTH EASTERN ITALY Veneto Biomedical Brain Disorders and Clinical Innovative biomarkers for oxidative stress in diabetic retinopathy: evaluation of curcumin inhibition. BIETTI Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Natural history of circulating Endothelial Progenitor Cells in aging of healthy subjects and during vascular injury progression in patients with type 1 diabetes. Validation of the role of circulating Endothelial Progenitor Cells as a novel paradigm of Ca Toscana Clinical Vascular and Hematology Omics study of competitive action of starter add on fresh meat production (italian salami) to improve safety Abruzzo Biomedical Infectious Diseases and Microbiology Food safety and animal welfare Impact of Atorvastatin Use on Death or clinical Events Occurrence among HIV 1 infected patients without hyperlipidemia. AUDEO Study SAN RAFFAELE Milano Clinical AIDS and Related Research 26 Pagina 215 di 231

216 IDENTIFICATION AND ANALYSIS OF MOLECULAR ALTERATIONS IN ENDOTHELIAL CELLS DERIVED FROM CEREBRAL CAVERNOUS MALFORMATIONS NEUROLESI Biomedical Brain Disorders and Clinical Chest pain in the Emergency Department : the role of diabetes, dyslipidemia and obesity in the incidence of ACS in population with/without a history of CAD. Mortality, reinfarction and survival related factors AOU San Martino IST Genova Clinical Population and Epidemiology Infective exacerbations of COPD, comorbidity and gender differences Puglia Clinical Cardiovascular and Respiratory Burden of disease of work related asthma Toscana Biomedical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Effects of peripheral sensory pressure stimulation on the cardiovascular autonomic profile, inflammatory state and movement disorders in patients with Parkinson's disease: evaluation of the time course and underlying neurophysiological mechanisms. A new c HUMANITAS Clinical Brain Disorders and Clinical 26, Role of autophagy and cell oxidation in Hungtinton Disease (HD) Piemonte Biomedical Brain Disorders and Clinical 26, Developing a Nutritional genomics approach for the prevention of Colon cancer Sicilia Biomedical Oncology 2 Translational Clinical Oncology 26,5 Pagina 216 di 231

217 DEACETILASE INHIBITORS AS NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Piemonte Biomedical Oncology 1 Basic Translational Oncology 26, Primary cancer cells as models to test new drugs and to personalize the therapy Campania Biomedical Oncology 2 Translational Clinical Oncology 26, Analysis of myocardial function after aortic valve replacement with a novel sutureless valve: coupling mathematical modelsto clinical research. Sicilia Clinical Surgical, Biomedical Imaging, and Bioengineering 26, DEVELOPMENT OF LABORATORY PROCEDURES TO ASSESS BIOFILM PRODUCTION AND DRUG RESISTANCE OF BIOFILM FORMING BACTERIA FOR NOSOCOMIAL SURVEILLANCE AND THERAPEUTIC MANAGEMENT SAN GALLICANO Clinical Infectious Diseases and Microbiology 26, Prevention of nosocomial Legionnaires' disease: use of spoligotyping in evaluating L. pneumophila susceptibility to chlorine and monochloramine. Sicilia Biomedical Infectious Diseases and Microbiology 26, Prevention of restenosis after percutaneous transluminal angioplasty (PTA) MULTIMEDICA Clinical Surgical, Biomedical Imaging, and Bioengineering 26, Intensive vs non intensive rehabilitation program in Parkinson's disease (PD) patients. Study for evaluating a non invasive approch to increase neurotrophic factors in the brain of PD patients. SANTA LUCIA Clinical Brain Disorders and Clinical 26,5 Pagina 217 di 231

218 Mens sana in corpore sano? The impact of multi year exercise on physical and mental health at different ages. Toscana Biomedical Risk, Prevention and Health Behavior 26, The oral modifications in very early and established Systemic Sclerosis Toscana Clinical Musculoskeletal, Oral and Skin 26, Pathophysiology of central fatigue in patients with multiple sclerosis: an integrated neurophysiologic and neuroimaging approach. NEUROLESI Clinical Brain Disorders and Clinical 26, Efficacy of Magnetic Fields stimulation for the treatment of human gastric cancer associated, or not, to pathogen Helicobacter pylori infection. Piemonte Biomedical Oncology 2 Translational Clinical Oncology 26, Multi disciplinary approach to predict adverse ventricular remodeling in post MI patients: combined evaluation of cardiac dysfunction and immune related biomarkers after revascularization procedure Lombardia Biomedical Cardiovascular and Respiratory 26, Application of optical nanoplasmonic biosensors as a complementary tool for the early detection of Legionella spp in water systems. (NANOBIOLEG) Puglia Biomedical Bioengineering and Technologies Diseases of environmental origin, with reference also to the workplace Hospital Procedures for acute heart failure and integrated country/hospital healthcare Sicilia Clinical Cardiovascular and Respiratory 27 Pagina 218 di 231

219 MELATONIN LOADED NANOPARTICLES FOR POSTNATAL TREATMENT OF CEREBRAL PALSY IN A RAT MODEL Toscana Biomedical Brain Disorders and Clinical The new biotechnologies Randomised Controlled Trial on lifestyle impact on health outcomes in the general population invited to mammography and colorectal cancer screening programmes. Piemonte Biomedical Risk, Prevention and Health Behavior Oncology Incidence and outcome of ocular infections caused by multi drug resistant microorganisms in intensive care unit patients: clinical, epidemiological and therapeutic management. Sicilia Clinical Infectious Diseases and Microbiology Human defensins: a new weapon or an old enemy? Campania Biomedical Immunology Primary Central Nervous System Vasculitis in the Young. A diagnostic and follow up study using 7 Tesla MRA. Toscana Clinical Brain Disorders and Clinical Effect of stress ( and psychological factors) on immune and endocrine systems in patients affected by breast carcinoma and hormone correlated tumours. I.N.R.C.A. Clinical Biobehavioral and Behavioral Processes Oncology Genetic characterization of Non Small Cell Lung Cancer (NSCLC) to evaluate intratumor heterogeneity and modification after Tyrosine Kinase Inhibitors' (TKI) failure C.R.O. AVIANO Clinical Oncology 1 Basic Translational Oncology 27 Pagina 219 di 231

220 Role of growth hormone releasing hormone (GHRH) in cardiac hypertrophy Piemonte Biomedical Cardiovascular and Respiratory Palitoxins: toxicity studies and development of new rapid methods of detection IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 27 welfare Eating disorders and risk factors for metabolic and s. A follow up study after ten years from the initial diagnosis Emilia Romagna Clinical Biobehavioral and Behavioral Processes Lab on chip technology and new clinical application Lazio Biomedical Bioengineering and Technologies The new biotechnologies Molecular pathogenetic mechanisms and prognosis of sinonasal adenocarcinomas in relation to occupational exposure Piemonte Clinical Oncology 2 Translational Clinical Oncology Chemical, biological, and clinical characterization of silver delivery systems for burns treatment Veneto Biomedical Bioengineering and Technologies The new biotechnologies 27, Randomized Controlled Trial on the efficacy of LLLT (Low Level Laser Therapy) in combination with standard treatment, in preventing and treating chemo/radiotherapy induced oral mucositis in head and neck cancer patients and in hematologic neoplasms patien ARCISPEDALE Reggio Emilia Clinical Healthcare Delivery and Methodologies Oncology 27, Molecular and cellular correlates of vitamin D dependent antimicrobial activity in an ovine model of local immunefunctions IZS Sardegna Biomedical Veterinary 27,5 Pagina 220 di 231

221 Titanium based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO Biomedical Bioengineering and Technologies The new biotechnologies 27, Copayment and compliance to the diagnostic therapeutic pathways AGENAS Clinical Healthcare Delivery and Methodologies 27, Endothelial progenitor cells, cardiovascular health and longevity.a prospective study in centenarians and their offspring from Marche. I.N.R.C.A. Biomedical Biology of Development and Aging 27, Gold compounds, potential anticancer agents with an innovative mode of action: mechanistic studies and in vivo evaluation Toscana Biomedical Oncology 2 Translational Clinical Oncology 27, Pulmonary Embolism: diagnosis, treatment, management and outcomes in a general hospital with a fully computerized information system. Lombardia Clinical Cardiovascular and Respiratory 27, Incidence, persistence and clearance of anal Human Papillomavirus infection in a cohort of immunocompetent and immunocompromised males: a longitudinal study. SAN GALLICANO Biomedical Infectious Diseases and Microbiology 27, Endocannabinoid system and Human Ovarian Tumors Campania Biomedical Oncology 2 Translational Clinical Oncology 28 Pagina 221 di 231

222 Early detection of the onset of potential risk in order to counteract and to prevent their spread. An introduction of an advanced computer system that, with a right level of automation, collect information available on the internet to monitor their conten IZS Lazio e della Toscana Biomedical Veterinary Food safety and animal 28 welfare Comparative Effectiveness of dual antiplatelet therapy after acute coronary syndromes Emilia Romagna Clinical Cardiovascular and Respiratory Myocardial Infarction in Low Risk Patients: Integrating Risk Assessment with Tissue Biomarkers and Metabolomics Toscana Clinical Cardiovascular and Respiratory Randomized controlled study for the implementation of a new interprofessional model for the management of palliative care in oncological patients Toscana Clinical Healthcare Delivery and Methodologies Oncology Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresitance Veneto Biomedical Oncology 2 Translational Clinical Oncology IMPROVING THERAPEUTIC RESPONSES IN MELANOMA THROUGH THE COMBINATION OF TARGET AND IMMUNOLOGIC THERAPIES: AN IN VITRO AND IN VIVO STUDY Lombardia Biomedical Oncology 2 Translational Clinical Oncology Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 28,25 welfare Pagina 222 di 231

223 Hemoglobin A1c (HbA1c) levels and early markers of : Sicilia Clinical Cardiovascular and Respiratory 28,25 identification of cardiometabolic risk in prediabetic subjects IMPLEMENTATION AND ASSESMENTOF AN ORGANIZATIONAL SIMULTANEOUS CARE MODEL Lazio Clinical Oncology 2 Translational Clinical Oncology 28, Implementation of reading/writing learning method called "Globalismo Affettivo" in children with Neuropsychiatric Disorders Puglia Clinical Brain Disorders and Clinical 28, Effects of Mirror Visual Feedback Therapy (MVFT) in neuropathic pain syndromes. Possible role played by sensory motor cortical reorganization evaluated by 3TfMRI. MAUGERI Clinical Integrative, Functional, and Cognitive 28, A new kinkless polyurethane silicone vascular graft implanted as femoropopliteal bypass for ischemic limb salvage: a pilot clinical study. Emilia Romagna Biomedical Surgical, Biomedical Imaging, and Bioengineering 28, Design and implementation of a national network for remote identification of parasite arthropodes. IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal 28,5 welfare Healthcare Associated Infections and Automated Area Decontamination: a challenge for the intended application, the evidence base for effectiveness, affordability of implementation and cost constraints Sicilia Clinical Infectious Diseases and Microbiology 28,5 Pagina 223 di 231

224 Detection and molecular characterization of Cryptosporidium, Giardia and Toxoplasma oocysts/cysts in bivalve mollusks destined for human consumption. IZS Sardegna Biomedical Veterinary Food safety and animal 29 welfare Improving therapeutical potential of histone deacetylases inhibitors in non small cell lung cancer REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology Transcranial Magnetic Stimulation in alcohol dependence Lazio Biomedical Brain Disorders and Clinical Building of MM associated vascular niche to dissect MM endothelial cells dialogue SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology Complementary and Alternative Medicine for the treatment of chronic pain: a pilot study NEUROLESI Clinical Biobehavioral and Behavioral Processes CHLORPYRIFOS, DELTAMETRIN AND DIAZINON, A REAL RISK FOR ANIMAL AND HUMAN HEALTH. EVALUATION OF GENOTOXICITY, OXIDATIVE STRESS, HORMONAL AND TISSUTAL RESPONSES IN FISH EXPERIMENTALLY EXPOSED TO PESTICIDES IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 29 welfare Enhancing and monitoring indoor and outdoor physical activity and its intracellular and quality of life effects in type 2 diabetic patients Lombardia Clinical Endocrinology, Metabolism, Nutrition and Reproductive 29 Pagina 224 di 231

225 Interactions between Circulating Tumor Cells (CTCs) and the hepatic microenvironment in human metastatic colorectal cancer: The ADAM 9 protein as a target for tumor/stromal therapy. DE BELLIS Biomedical Oncology 1 Basic Translational Oncology 29, Melanoma and non melanoma skin cancer: anatomic site, sun exposure, predictive and prognostic biomarkers SAN GALLICANO Clinical Oncology 1 Basic Translational Diseases of environmental 29,5 origin, with reference also to the workplace Hypermethylation and downregulation of IRX1 gene induced by Helicobacter pylori infection: etiopathogenetic role in gastric cancer development, prognostic impact after surgical resection and diagnostic employment as screening test SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology 29, Proteomic profiling of hematological malignancies by Reverse Phase Protein Array: an innovative traslational approach to identify biomarkers for prognosis and molecular therapy. Lazio Biomedical Oncology 2 Translational Clinical Oncology 29, FROM REMOTE MONITORING TO REMOTE CARE: IMPACT ON CLINICAL AND MANAGEMENT ISSUES OF AN INTEGRATED APPROACH TO FOLLOW HEART FAILURE PATIENTS WITH IMPLANTABLE CARDIAC DEVICES. Emilia Romagna Clinical Cardiovascular and Respiratory 29,75 Pagina 225 di 231

226 Zoonotic risks assessment of the handling and consumption of meat from main wild ungulates (wild boar/sus scrofa, roe deer/capreolus capreolus) hunted in Nord Italy (Aosta Valley Region) and South Italy (Calabria Region) IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 30 welfare From psycho social stress to immunomediated dermatoses (vitiligo and psoriasis): a molecular approach. Toscana Biomedical Immunology Definition of an Integrated Risk Assessment of Health Care Worker Biomechanical Musculoskeletal Overload Sicilia Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by the Program of Molecular & Clincical Endocrinology and Women's Endocrine Health. Sicilia Clinical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Clinical implications of gene polymorphism (TAAA)n of sex hormone binding globulin in breast cancer patients with or without hormone therapy. ONCOLOGICO DI BARI Biomedical Genes, Genomes and Genetics Oncology MICROENVIRONMENT INFLUENCE ON CANCER STEM CELL DEVELOPMENT Veneto Biomedical Oncology 1 Basic Translational Oncology 30 Pagina 226 di 231

227 Role of LXR alpha and related target genes in the pathogenesis of atherosclerosis. Evaluations in patients with different stages of atherosclerotic disease. Lombardia Biomedical Cardiovascular and Respiratory MECHANOTRANSDUCTION FOR THE TREATMENT OF OSTEOPOROSIS: MECHANISM OF ACTION, PRECLINICAL AND CLINICAL EFFICACY OF EXTRACORPOREAL SHOCK WAVES (ESW) FOR THE PREVENTION OF PATHOLOGICAL FEMORAL NECK FRACTURES RIZZOLI Biomedical Musculoskeletal, Oral and Skin The new biotechnologies A translational medicine research collaboration to fight preeclampsia: from molecular pathogenesis to biomarkers of the disease and novel treatments Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 30, Validation of Augmented Reality Navigation for HIFU Treatments Toscana Clinical Surgical, Biomedical Imaging, and Bioengineering Oncology Production of honey based materials from Italian honey and their application in medicine and surgery Piemonte Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies Short term cultures of surgical tissue slices to evaluate the sensitivity of breast cancer subtypes to the anti tumor effects of alltrans retinoic acid and derived retinoids: identification of the cellular and molecular determinants ARCISPEDALE Reggio Emilia Biomedical Oncology 2 Translational Clinical Oncology 31 Pagina 227 di 231

228 Realization of a protocol for the rapid identification of etiological agent/s responsible for sepsis directly from peripheral blood of septic subjects, by integration of molecular biology, massspectrometry and classical methods. Toscana Biomedical Infectious Diseases and Microbiology The new biotechnologies Outcome of Rehabilitation in an experimental Hospital garden: a prospective, quasi experimental study on a sample of subacute stroke patients. Emilia Romagna Clinical Brain Disorders and Clinical Study of bio molecular and immunological mechanisms of response and resistance to targeted therapy (antibraf, antimek, or both) in patients with metastatic melanoma ONCOLOGICO DI BARI Biomedical Oncology 2 Translational Clinical Oncology SOW Project: safety on work. An intervention to increase attention of workers, making them aware of risky behavior in psychoactive substances consumption. Campania Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 31, Colorectal cancer stem cells, microenvironment and improved diagnosis for potential therapy Toscana Biomedical Oncology 1 Basic Translational Oncology 31, Risk maps of MAP (Mycobacterium avium subsp. paratuberculosis) using advances technologies IZS Lazio e della Toscana Biomedical Veterinary 31,5 Pagina 228 di 231

229 Colorectal carcinogenesis: Study, in vivo and in vitro, of the molecular mechanisms of cell differentiation of the human colon cancer cells DE BELLIS Biomedical Oncology 1 Basic Translational Oncology 31, Aerobiological monitoring and allergy management in Abruzzo Abruzzo Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 31, Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Biomedical Digestive, Kidney and Urological Systems The new biotechnologies 31, Development and performance evaluation of different assays for the study of the presence of viable Toxoplasma gondii in vegetable and meat IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 32 welfare Dissecting the role of chronic stress and its consequences on tumor growth and metastasis in animal models PASCALE Biomedical Oncology 1 Basic Translational Oncology Population based active surveillance of acute HIV infection. SAN MATTEO Clinical AIDS and Related Research 32, Link between clinical features of haematological patients, molecular and cytofluorimetric data: WT1 and relationship with other markers. Basilicata Clinical Oncology 2 Translational Clinical Oncology 32, Mechanisms and actions of Regorafenib (Stirvaga), a new hepatocarcinoma (HCC) therapy DE BELLIS Biomedical Oncology 1 Basic Translational Oncology 32,5 Pagina 229 di 231

230 Estimate of breast cancer risk in relation to mammographic density by using a software for automatic evaluation of the density. Toscana Biomedical Population and Epidemiology Oncology Evaluation of the immune response against Mycobacterium avium subsp. paratuberculosis in humans and animals IZS Umbria e delle Marche Biomedical Veterinary 33, Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. Toscana Biomedical Oncology 1 Basic Translational Oncology 33, Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Toscana Biomedical Brain Disorders and Clinical AN ITALIAN REGISTER OF NEONATAL EPILEPTIC ENCEPHALOPATHY Emilia Romagna Clinical Brain Disorders and Clinical 34, Application of nanomechanical assays to detection of algal toxins IZS Lombardia e dell'emilia Biomedical Veterinary Food safety and animal 34,5 welfare The integrated and multi disciplinary management of patients with peripheral arterial disease and lower limbs trophic lesions: improving adherence and quality of life Sicilia Clinical Risk, Prevention and Health Behavior Sexual dysfunction after Traumatic Brain Injury and consequences on couple relationship: assessment and treatment. SANTA LUCIA Biomedical Brain Disorders and Clinical 35,5 Pagina 230 di 231

231 Direct management of litigation: a real chance to improve the Italian National Health System Toscana Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 39 Pagina 231 di 231