Ministero della Salute

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1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 GIOVANI RICERCATORI e RICERCA FINALIZZATA Tutte le Sezioni RODDI New Robotic Platform for Rehabilitation of Children with Pervasive Developmental Disorders and Cognitive Impairments. Multipotent Stem/Progenitor Cells in Human Extrahepatic Biliary Tree: isolation, culturing, differentiation in vitro and in vivo, identification of intracellular pathways modulating proliferation and differentiation and development of strategies for the t EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread Role of morgana/chp 1 in myeloproliferative disorders mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity CARLO BESTA CLI ORD Biobehavioral and Behavioral Processes Marche ORD Digestive, Kidney 4, and Urological Systems C.R.O. AVIANO ORD Oncology 1 Basic 4, Piemonte ORD Oncology 1 Basic 4, Istituto Superiore di Sanita' ORD Oncology 1 Basic 4, MAUGERI CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 4, Pagina 1 di 332

2 Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 4, Definition of mechanisms controlling processing and secretion of IL 1beta in health and autoinflammatory diseases, search for novel therapeutic strategies IRCCS AOU San Martino IST (Genova) ORD Immunology 4, NEW GENETIC LESIONS CHARACTERIZING HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS Characterization of the histone deacetylase SIRT1 in human Non Hodgkin Lymphomas and lymph nodes. Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia Piemonte EST Oncology 2 4, ARCISPEDALE ORD Oncology 1 Basic SANTA LUCIA ORD Brain Disorders and Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO CLI ORD Oncology High density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo EEG and post surgical outcome evaluation Lombardia CLI EST Brain Disorders and Gene therapy for thalassemia: preclinical studies of efficacy and safety SAN RAFFAELE MONTE TABOR ORD Genes, Genomes and Genetics PROTECTIVE AND DANGEROUS IMMUNE RESPONSES DURING HIV 1 INFECTION OSPEDALE BAMBINO GESU' CLI EST AIDS and Related Research Pagina 2 di 332

3 The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' ORD Oncology 1 Basic Piemonte CLI ORD Oncology Istituto Superiore di Sanita' ORD Immunology Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, and Developmental STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER Impaired Angiogenesis: a Novel Player and Potential Therapeutic Target in Muscular Dystrophy Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive Istituto Superiore di Sanita' ORD Musculoskeletal, Oral and Skin CARLO BESTA CLI ORD Oncology HUMANITAS ORD Oncology 1 Basic FATEBENEFRATELLI ORD Brain Disorders and 5, Pagina 3 di 332

4 Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 5, Role of Nuclear Receptor Coactivator PGC1 beta in the Intestinal Epithelium Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes ONCOLOGICO DI BARI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5, Lazio CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5, Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 5, and Genetics Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia CLI ORD Population 5, and Epidemiology Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche ORD Molecular, Cellular, 5, and Developmental Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA ORD Musculoskeletal, 5, Oral and Skin Thrombolysis in Minor Stroke Emilia Romagna CLI ORD Brain Disorders and 5, Pagina 4 di 332

5 Novel surface and intracellular targets for tailored nanotechnology based drug delivery in colorectal cancer NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES SDN EST Oncology 1 Basic 5, Istituto Superiore di Sanita' ORD Bioengineering 5, and Technologies Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 5, IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V GASLINI ORD Genes, Genomes 5, and Genetics Emilia Romagna CLI ORD Digestive, Kidney 5, and Urological Systems A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney 5, and Urological Systems Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. TRANSLATING MELANOMA EPIGENETICS IN THE CLINICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5, MAUGERI ORD Oncology 1 Basic 5, (2) Toscana ORD Oncology 2 5, Pagina 5 di 332

6 In vivo confocal microscopy of corneal nerves as a novel diagnostic tool in peripheral neuropathies: correlation with skin biopsy, neurophysiology and clinical findings. Standardizing tissue handling in pre analytical procedures: technological, environmentally safe innovation in solid tumour processing. "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. CANDIDATE PREDICTORS OF GLUCOCORTICOID RESPONSE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE Neuroinflammation and synaptic function: an electrophysiological analysis in experimental multiple sclerosis Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? Role of TNF related apoptosis inducing ligand (TRAIL) in diabetes mellitus and metabolic syndrome Lombardia CLI ORD Brain Disorders and Piemonte CLI COF Healthcare Delivery and Methodologies MAGGIORE ORD Digestive, Kidney and Urological Systems BURLO GAROFALO CLI ORD Digestive, Kidney and Urological Systems Umbria ORD Brain Disorders and S.CAMILLO ORD Brain Disorders and BURLO GAROFALO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Nurr1 puts a dampener on inflammation: a link Piemonte ORD Brain Disorders and between Nurr1 deregulation and Multiple Sclerosis RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio ORD Cell Biology Pagina 6 di 332

7 Transcranial direct current stimulation in the treatment of dyslexia: a randomized double blind study OSPEDALE BAMBINO GESU' ORD Brain Disorders and PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO CLI ORD Cardiovascular and Respiratory Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, Oral and Skin Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high throughput innovative approaches. GASLINI EST Digestive, Kidney and Urological Systems Identification and functional validation of microrna biomarkers in lung cancer ISTITUTO TUMORI MILANO EST Oncology Perivascular adipose tissue mirnas: links between insulin resistance in type 2 diabetes and vascular disease ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Endocrinology, Metabolism, Nutrition and Reproductive Insulin resistance and cancer:new strategies of intervention involving the insulin receptor isoform A THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive SAN DONATO CLI ORD Population and Epidemiology Pagina 7 di 332

8 Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer. Improving balance through gravity cues embedded in free falling target Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Autophagy in the immune response against Mycobacterium tuberculosis: identification of novel rapamycin regulated host targets to improve BCG vaccine immunogenicity. Lombardia ORD Brain Disorders and Emilia Romagna ORD Brain Disorders and Toscana CLI EST Oncology SANTA LUCIA ORD Biobehavioral and Behavioral Processes Toscana ORD Immunology Istituto Superiore di Sanita' EST Infectious Diseases and Microbiology Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, Oral and Skin IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO CLI ORD Oncology And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA ORD Biobehavioral and Behavioral Processes Pagina 8 di 332

9 B7.1 on podocytes: a new therapeutic target for diabetic nephropathy SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney and Urological Systems Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man SAN RAFFAELE MONTE TABOR ORD Population and Epidemiology Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA CLI ORD Brain Disorders and THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING CLINICAL DISORDERS SAN RAFFAELE MONTE TABOR ORD Vascular and Hematology FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. SAN RAFFAELE MONTE TABOR ORD Genes, Genomes and Genetics Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. Autosomal Recessive Juvenile Parkinsonism (ARJP) caused by mutation in the PARK2 gene: Identification of the molecular mechanisms by which parkin can modify GluK2 activity and investigation of GluK2 as new target for a neuroprotective therapy Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer PASCALE ORD Oncology 1 Basic AUXOLOGICO ORD Brain Disorders and Calabria ORD Oncology Pagina 9 di 332

10 Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana CLI ORD Cardiovascular and 6, Respiratory MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio CLI ORD Vascular and 6, Hematology The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY MitoCure: developing treatments for mitochondrial diseases Generation and characterization of an anticd56 IL15 immunocytokine for functional reconstitution of NK cells in HIV infection FATEBENEFRATELLI CLI ORD Biobehavioral and 6, Behavioral Processes C.R.O. AVIANO EST Vascular and 6, Hematology CARLO BESTA ORD Genes, Genomes 6, and Genetics Istituto Superiore di Sanita' ORD AIDS and Related 6, Research Amyotrophic lateral sclerosis (ALS) swine models: production and characterization Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Brain Disorders and 6, Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine Mechanisms of diabetes resolution after bariatric surgery: role of the gut SAN MATTEO EST Immunology 6, Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 6, Pagina 10 di 332

11 CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 6, A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. INTEGRATED ''OMIC'' APPROACH TO EXPLORE MOLECULAR PATHOGENESIS AND CLINICAL HETEROGENEITY IN FACIO SCAPULO HUMERAL MUSCULAR DYSTROPHY Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Emilia Romagna CLI ORD Digestive, Kidney 6, and Urological Systems Toscana ORD Molecular, Cellular, 6, and Developmental SAN RAFFAELE PISANA ORD Brain Disorders and 6, STELLA MARIS ORD Musculoskeletal, 6, Oral and Skin Piemonte CLI ORD Brain Disorders and 6, Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 6, (5) Novel markers based on autophagy proteins in Parkinson's disease NEUROMED CLI ORD Brain Disorders and 6, Pagina 11 di 332

12 The ubiquintin editing enzyme A20 (TNFAIP3) as a peacekeeper in inflammation and immunity: a link between TNFAIP3 deregulation and Multiple Sclerosis Spinal Muscular Atrophy with Respiratory Distress (SMARD1): gene therapy as novel therapeutic approach Genetics of Hearing loss: from basic research to clinical applications Piemonte ORD Brain Disorders and 6, MAGGIORE ORD Genes, Genomes 6, and Genetics BURLO GAROFALO CLI ORD Genes, Genomes 6, and Genetics Impact of lincrnas on high serous ovarian cancer C.R.O. AVIANO ORD Oncology 1 Basic 6, The Restless Mind: Default Mode Of Operation Or Risk Factor For Health? Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a Preparatory, response related, outcomeevaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation SANTA LUCIA ORD Biobehavioral and 6, Behavioral Processes GASLINI ORD Genes, Genomes 6, and Genetics SANTA LUCIA CLI EST Biobehavioral and 6, Behavioral Processes Istituto Superiore di Sanita' ORD Brain Disorders and 6, CARLO BESTA ORD Molecular, Cellular, 6, and Developmental DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO ORD Oncology 2 6, Pagina 12 di 332

13 Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia Role of the Wnt/beta catenin pathway in orchestrating epigenetic events in Cancer Stem Cells I.E.O. ORD Oncology 1 Basic 6, Toscana ORD Genes, Genomes 6, and Genetics Regulation of mitotic transitions I.E.O. ORD Cell Biology 6, Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease IRCCS AOU San Martino IST (Genova) EST Molecular, Cellular, 6, and Developmental Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis SAN RAFFAELE MONTE TABOR ORD Musculoskeletal, 6, Oral and Skin Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) ORD Biological Chemistry and Macromolecular Biophysics 6, Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO EST Oncology 2 6, P2X7 receptor/mmp9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression SAN RAFFAELE MONTE TABOR EST Vascular and 6, Hematology Pagina 13 di 332

14 A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. SAN RAFFAELE MONTE TABOR ORD Oncology 2 6, Production and characterization of clinical grade stem cell derived conditioned medium for treatment of ischemic heart disease. SAN MATTEO ORD Cardiovascular and 6, Respiratory Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 6, and Urological Systems The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment BCR ABL specific T cell Infusion for the Treatment of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery Role of HMGB1 redox state in cardiac tissue regeneration and cardiac progenitor cell function SANTA LUCIA ORD Genes, Genomes 6, and Genetics Emilia Romagna CLI ORD Oncology 2 6, MAGGIORE ORD Brain Disorders and 6, MONZINO ORD Cardiovascular and 6, Respiratory Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases SAN RAFFAELE MONTE TABOR ORD Cell Biology 6, ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria ORD Brain Disorders and 6, Pagina 14 di 332

15 Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 6, Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. mtor dependent oscillatory metabolic switch controlling self immune tolerance Development of new IVD CE molecular diagnostic tests for the detection of epigenetic defects involved in human disease Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs. SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive 6, SANTA LUCIA EST Immunology 6, MAGGIORE COF Genes, Genomes (1) and Genetics Emilia Romagna CLI EST Healthcare Delivery and Methodologies Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) ORD Immunology Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic The role of IG20, a novel human gene, and its potential use as therapeutic target in the anaplastic thyroid cancer. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 15 di 332

16 Reorganization of cortical function after surgery for lesional epilepsy in children Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation The effects of diabetic autonomic neuropathy on post ischemic bone marrow mobilization of endothelial progenitor cells. A translational study focusing on the role of Sirtuin 1 Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Adipose Derived Stem Cells (ADSCs) in Suspension: Phenotyping, Differentiation and Engineering for Cranial Vault Reconstruction. Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome Toscana CLI ORD Brain Disorders and Sicilia ORD Infectious Diseases and Microbiology Veneto ORD Vascular and Hematology Lombardia CLI ORD Cardiovascular and Respiratory Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering NEUROMED ORD Cardiovascular and Respiratory Noncoding RNAs and cancer IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES: PREVALENCE ANDVIRO IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE IRCCS AOU San Martino IST (Genova) EST Immunology Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development A translational approach to restrain local recurrence in early breast cancer patients Lombardia ORD Biology of Development and Aging C.R.O. AVIANO ORD Oncology 1 Basic Pagina 16 di 332

17 Role of peripheral Schwann cells and muscle in the regeneration of degenerated nerve terminals at the neuromuscular junction. Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia Veneto ORD Brain Disorders and Veneto ORD Brain Disorders and SAN MATTEO CLI ORD Genes, Genomes and Genetics Dysregulated RNA metabolism in multiple myeloma. SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth. C.R.O. AVIANO EST Oncology 1 Basic New nuclear genes responsible for mitochondrial disorders: identification by high throughput exome sequencing and functional characterization of the corresponding proteins CARLO BESTA ORD Genes, Genomes and Genetics Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications. CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine Abruzzo EST Oncology 1 Basic Istituto Superiore di Sanita' ORD AIDS and Related Research Istituto Superiore di Sanita' EST Musculoskeletal, Oral and Skin Pagina 17 di 332

18 Cytokines as biomarkers of disease and therapeutic targets in laminopathies Role of ATM kinase in ErbB2 signaling: a novel therapeutic target to hit ErbB2 positive breast cancer stem cells? Brain and cognitive dynamics of multiple object processing in normal aging, MCI and Alzheimer disease RIZZOLI ORD Biology of Development and Aging SANTA LUCIA ORD Oncology FATEBENEFRATELLI ORD Biobehavioral and Behavioral Processes Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Idiopathic epilepsy: search for new mutations in HCN ion channels Brain plasticity in Alzheimer Disease and Mild Cognitive Impairment. Functional, structural and neuropsychological effects of a computer based cognitive treatment Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology CARLO BESTA ORD Brain Disorders and SANTA LUCIA CLI ORD Brain Disorders and Role of influenza virus infection in the etiopathogenesis of diabetes Istituto Zooprofilattico Sperimentale delle Venezie EST Infectious Diseases and Microbiology Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1. Toscana EST Molecular, Cellular, and Developmental Pagina 18 di 332

19 Nerve Growth Factor eye drops as a novel treatment for vision loss in patients with Retinitis Pigmentosa: from preclinical to clinical Phase II trial. SAN RAFFAELE MONTE TABOR CLI COF Brain Disorders and TArgeted Multistage vector (MSV) for the DIagnosis and treatment of Solid tumors Veneto EST Bioengineering and Technologies Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' CLI ORD Infectious Diseases and Microbiology Pemphigus vulgaris as a paradigm of autoantibodymediated organ specific autoimmune disorder: DERMOPATICO ISTITUTO pathophysiology and novel tools for diagnosis and DELL'IMMACOLATA therapy EST Musculoskeletal, Oral and Skin Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA ORD Brain Disorders and To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes and Genetics Enhanced cell proliferation for muscle repair and regenerative medicine Interleukin 27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg / mice with human immune system GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinsons Disease SALUTE CKD (SALt lowering by Urine sodium self measurement Trial in Chronic Kidney DiseasE) Istituto Superiore di Sanita' ORD Musculoskeletal, Oral and Skin GASLINI EST Immunology SAN RAFFAELE PISANA CLI ORD Brain Disorders and Calabria CLI ORD Risk, Prevention and Health Behavior Pagina 19 di 332

20 Micro RNAs regulated by the proto oncogene Pbx1 as therapeutic targets to induce differentiation of cancer cells Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach. Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Role of APOBEC1 in the initiation and progression of cancer HUMANITAS ORD Oncology Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology MAGGIORE EST Musculoskeletal, Oral and Skin Lombardia EST Oncology 1 Basic Istituto Superiore di Sanita' ORD Oncology 1 Basic Toscana ORD Oncology 1 Basic Early detection and treatment of recurrent, chemotherapy resistant ovarian cancer stem cells by CPE peptide complexed superparamagnetic iron oxide nanoparticles (CPE SPIONs) ISTITUTO TUMORI MILANO EST Oncology Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA ORD Oncology MULTITHERAPEUTIC APPROACH TO THE SPINAL CORD INJURY BYSMART HYDROGEL DELIVERY A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. MAGGIORE ORD Brain Disorders and PASCALE ORD Oncology Pagina 20 di 332

21 Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA ORD Brain Disorders and FEEDING LOW GRADE INFLAMMATION AND INSULIN RESISTANCE OF THE FOETUS OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI CLI ORD Musculoskeletal, Oral and Skin RIZZOLI CLI ORD Musculoskeletal, Oral and Skin Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multipathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 7, (5) Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE CLI ORD Genes, Genomes 7, and Genetics Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer polypeptide vaccine directed against the thymidylate synthase enzyme. Toscana CLI ORD Oncology 2 7, INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYCLIC DI GMP METABOLISM Lazio ORD Infectious Diseases 7, and Microbiology MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA ORD Oncology 1 Basic 7, Pagina 21 di 332

22 Fall prevention and locomotion recovery in poststroke patients: a multimodal training towards a more autonomous daily life Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Cognitive, physiological and imaging correlates of visual hallucinations in Lewy body dementia: a multimodality functional study The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches MAUGERI CLI ORD Musculoskeletal, 7, Oral and Skin Piemonte CLI ORD Cardiovascular and 7, Respiratory S.CAMILLO CLI EST Brain Disorders and 7, PASCALE ORD Oncology 1 Basic 7, Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 7, (5) Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI ORD Brain Disorders and 7, IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 7, and Developmental Role of the meniscus in OA pathology and symptoms RIZZOLI ORD Musculoskeletal, 7, Oral and Skin Deregulation of molecular cross talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment. CASA SOLLIEVO SOFFERENZA EST Oncology 2 7, (4) Pagina 22 di 332

23 Modulation of FoxO1 antioxidant function to prevent aging related disorders:diabetes and atherosclerosis Abruzzo EST Biology of 7, Development and Aging Involvement of micrornas in triple negative breast cancer: from biology to possible therapeutic applications. ISTITUTO TUMORI MILANO EST Oncology 1 Basic 7, (4) Role of novel modulators of ectopic mineralization during aortic valve disease progression Veneto ORD Vascular and 7, Hematology MacroH2A1 in the pathogenesis of metabolic syndrome associated hepatocellular carcinoma CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 7, (4) Nanotechnology based approach for induction of immune tolerance Lazio EST Bioengineering 7, and Technologies The topological organization of anatomical and functional cortical brain networks in patients with the behavioral variant of frontotemporal dementia and primary progressive aphasia SAN RAFFAELE MONTE TABOR CLI ORD Biobehavioral and 7, Behavioral Processes Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models MEDEA ORD Brain Disorders and 7, White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 7, and Genetics Health literacy and patient empowerment through the development of an e health information system Istituto Superiore di Sanita' CLI ORD Healthcare Delivery 7, and Methodologies Pagina 23 di 332

24 IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED CLINICAL PARAMETERS GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT CLINICAL IMPLICATIONS Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. Role of the immunological impairment in progression of from MGUS to Multiple Myeloma MULTIMEDICA CLI ORD Oncology 2 7, (2) SANTA LUCIA ORD Brain Disorders and 7, SAN RAFFAELE PISANA ORD Brain Disorders and 7, Sicilia EST Oncology 1 Basic 7, Role of Th22 lymphocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Immunology 7, Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia ORD Genes, Genomes 7, and Genetics CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 7, and Genetics Pagina 24 di 332

25 Tailoring the choice of P2Y12 oral receptor blocker by integrating clopidogrel loss of function alleles to phenotype assessment via point of care testing versus standard of care in patients who undergo percutaneous coronary intervention: A randomized mult Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cell based immunotherapy in patients with refractory disease Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. Amniotic Fluid Stem Cells (AFSCs): molecular markers of osteogenic differentiation and preclinical studies of orthopedic and odontoiatric diseases. Molecular mechanisms underlying metabotropic glutamate (mglu) receptor dysfunction in Fragile X syndrome Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy Nanotechnology for the multiplex diagnosis of infectious diseases NOVEL APPROACH FOR BONE REGENERATION AND REPAIR USING SULFUR DONOR BASED THERAPY MAUGERI ORD Cardiovascular and 7, Respiratory SAN MATTEO CLI ORD Oncology 2 7, SAN RAFFAELE PISANA ORD Musculoskeletal, 7, Oral and Skin Abruzzo EST Biology of 7, Development and Aging OASI MARIA S.S. EST Molecular, Cellular, 7, and Developmental SANTA LUCIA ORD Genes, Genomes 7, and Genetics Istituto Superiore di Sanita' EST Infectious Diseases 7, and Microbiology RIZZOLI EST Musculoskeletal, 7, Oral and Skin Pagina 25 di 332

26 Role of micrornas 143 and 145 in cardiovascular physiology and disease: from bench to bedside MULTIMEDICA ORD Vascular and 7, Hematology Development of optical methods for preclinical imaging using radiotracers SAN RAFFAELE MONTE TABOR ORD Bioengineering 7, and Technologies Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' CLI ORD Oncology 1 Basic 7, Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO ORD Oncology 2 7, AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA ORD Musculoskeletal, 7, Oral and Skin From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic 7, Alteration in cortical parvalbuminergic System in murine model of Huntington s Disease: Pharmacological effect of Phosphodiesterase type 4 (PDE4) inhibition. Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure Electronic health databases as a source of reliable information for effective health policy SANTA LUCIA ORD Brain Disorders and 7, AUXOLOGICO CLI ORD Cardiovascular and 7, Respiratory Puglia CLI ORD Healthcare Delivery and Methodologies Pagina 26 di 332

27 Planar haptic device and virtual reality tools for hand and finger rehabilitation Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cellpermeable peptides in preclinical models IMMUNOLOGICAL IMPACT OF SILIBININ TREATMENT FOR HCV RECURRENCE IN STABLE LIVER TRANSPLANTED PATIENTS MSC based therapy for the bone marrow and solid organs transplantations Striatal cholinergic interneurons as a novel target for the treatement of Parkinson's disease S.CAMILLO CLI COF Musculoskeletal, Oral and Skin Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Toscana CLI ORD Brain Disorders and Sicilia CLI ORD Digestive, Kidney and Urological Systems Calabria ORD Brain Disorders and MAUGERI ORD Brain Disorders and Puglia CLI COF Immunology Lombardia CLI ORD Oncology Umbria ORD Brain Disorders and Pagina 27 di 332

28 MiRNAs in Forebrain Neurogenesis SAN RAFFAELE MONTE TABOR ORD Biology of Development and Aging Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) BURLO GAROFALO CLI ORD Vascular and Hematology S.CAMILLO ORD Brain Disorders and Piemonte ORD Digestive, Kidney and Urological Systems REGINA ELENA ORD Oncology 1 Basic Piemonte ORD Oncology 1 Basic Role of relaxin in bone metastasis Veneto EST Oncology 1 Basic Climate, global drivers and immunodeficiency: effects on the leishmaniosis transmission patterns in Central Italy and appropriate diagnostic flow charts Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana ORD Brain Disorders and Pagina 28 di 332

29 Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCVassociated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB ORD Oncology 1 Basic Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and Toward the development of an in vitro test for ALS: large scale validation of PBMC protein biomarkers Unravelling the genetic basis of limb defects through a combined genomic and functional approach Characterization and functions of ROR{gamma}t+ IL22 producing innate lymphoid cells in autoimmune and neoplastic human diseases The endocannabinoid system as a therapeutic target to counteract remote degeneration after spinal cord injury. The role of TRAP1 in the resistance to anti EGFR1 agents in human colorectal carcinoma Search for novel genes involved in heterogeneous Cryopyrin associated periodic syndromes (CAPS) like autoinflammatory disorders Undifferentiated thyroid carcinoma: role of the Twist1 transcription factor Lombardia CLI ORD Brain Disorders and Emilia Romagna ORD Genes, Genomes and Genetics Sicilia EST Immunology SANTA LUCIA CLI ORD Brain Disorders and CROB ORD Oncology GASLINI ORD Genes, Genomes and Genetics SDN ORD Oncology 1 Basic Pagina 29 di 332

30 Identification of therapeutic targets for SAN RAFFAELE MONTE neurological disorders: analysis of the mechanisms TABOR regulating cortical interneurons development. ORD Molecular, Cellular, and Developmental Role of autophagy in growth, progression and vascular mimicry of neuroblastoma Immune gene expression and white matter pathology in first manic patients before and after treatment. A multimodal imaging genetic study GASLINI ORD Oncology 1 Basic Veneto CLI ORD Brain Disorders and Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' ORD Brain Disorders and Attention control in complex environments: mechanisms of spatial orienting in the intact and the damaged human brain NACHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER INVESTIGATION OF THE MOLECULAR BASES OF CARDIOMYOPATHY IN IMMUNOGLOBULIN LIGHT CHAIN (PRIMARY) AMYLOIDOSIS SANTA LUCIA CLI ORD Integrative, Functional, and Cognitive REGINA ELENA ORD Oncology SAN MATTEO ORD Cardiovascular and Respiratory Development of novel DNA based analytical methods for bacteria detection to improve food safety Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary Pagina 30 di 332

31 Targeting CD99 to treat sarcomas RIZZOLI ORD Oncology EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA FATEBENEFRATELLI CLI ORD Healthcare Delivery and Methodologies GALEAZZI ORD Oncology 1 Basic Identification and validation of mirnas as novel biomarkers and therapeutic targets in diffuse malignant peritoneal mesothelioma ISTITUTO TUMORI MILANO EST Oncology Kinetochore spindle binding as a new anticancer drug target. Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody I.E.O. ORD Oncology Istituto Superiore di Sanita' ORD Immunology Deleted in Breast Cancer 1, a new player in the DNA damage response. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia ORD Cardiovascular and Respiratory Development and preclinical assessment of an innovative endovascular device to occlude prosthetic paravalvular leakage Veneto EST Bioengineering (4) and Technologies Pagina 31 di 332

32 Nanostructured Coatings Enhancing Material Performances in Joint Arthroplasty RIZZOLI ORD Bioengineering and Technologies NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Definition of the epigenetic signature in Multiple Myeloma by high resolution DNA methylation profiling and integrated analysis with genomic imbalance, gene and microrna expression. Molecular mechanisms involved in skeletal muscle repair and muscular dystrophy Toscana CLI ORD Cardiovascular and Respiratory CROB ORD Oncology 1 Basic SAN RAFFAELE PISANA ORD Musculoskeletal, Oral and Skin Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary (5) The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role MONZINO ORD Vascular and Hematology Pagina 32 di 332

33 New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. Frontal circuit dysfunction as a marker of dementia in parkinsonism SAN MATTEO CLI EST Surgical, Biomedical Imaging, and Bioengineering (4) Istituto Superiore di Sanita' CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive MAUGERI ORD Cardiovascular and Respiratory NEUROLESI ORD Brain Disorders and IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS SAN RAFFAELE MONTE TABOR ORD Genes, Genomes and Genetics Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' ORD Oncology Optimization of alloreactive natural killer (NK) OSPEDALE BAMBINO cell and invariant NKT (inkt) cell mediated antileukemia effect in children with hematological GESU' malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel CLI ORD Oncology Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' ORD Genes, Genomes and Genetics Pagina 33 di 332

34 A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' CLI ORD Healthcare Delivery and Methodologies Development of novel cell products for their clinical use in cancer immunotherapy High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices Istituto Superiore di Sanita' ORD Oncology Calabria EST Bioengineering (4) and Technologies RELEVANCE OF TMEM16A PROTEIN (ANOCTAMIN 1) IN THE PATHOPHYSIOLOGY OF CYSTIC FIBROSIS AND GASTROINTESTINAL MOTILITY DISORDERS GASLINI EST Cell Biology Prevention and Treatment of Hardware Infection Through Titanium Surface Modifications and Improved Wound Healing Through Nanoparticle Delivery Mechanisms. MAUGERI EST Bioengineering and Technologies Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia CLI ORD Oncology 1 Basic 8, Optoelectronic retinal prosthesis: the astrocyte approach to visual restoration. Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV 1 infection and reactivation from latency Toscana EST Emerging Technologies and Training in s 8, Istituto Superiore di Sanita' EST AIDS and Related 8, Research Pagina 34 di 332

35 Post partum depression:chronobiology, sleeprelated risk factors and light therapy An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study Emilia Romagna CLI EST Risk, Prevention and Health Behavior 8,5 0 ARCISPEDALE CLI ORD Healthcare Delivery 8, and Methodologies Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio CLI ORD Brain Disorders and 8, LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab UNRESECTABLE IN TRANSIT METASTATIC MELANOMA: ELECTROCHEMO THERAPY VERSUS ELECTROIMMUNOTHERAPY. LOCAL AND SYSTEMIC EFFECTS. The contribution of ICT to patient safety in surgical process Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department I. O. V. CLI ORD Oncology 2 8, PASCALE CLI COF Oncology 2 8, Emilia Romagna CLI ORD Healthcare Delivery 8, and Methodologies BURLO GAROFALO CLI ORD Digestive, Kidney 8, and Urological Systems Toscana CLI ORD Healthcare Delivery 8, and Methodologies Identification of mirnas involved in the regulation of ALK expression in neuroblastoma IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic 8, (4) Pagina 35 di 332

36 Modulation of calcium release activated calcium modulator 1 (ORAI 1) and Stromal interaction molecule 1 (STIM1) activity as a new therapeutical strategy in stroke THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA lipidomic investigations in Multiple Sclerosis: research ofmolecular biomarkers ROLE OF REGULATORY T CELLS IN THE PATHOGENESIS AND THERAPY OF PRIMARY MYELOFIBROSIS Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. NUTRIGENOMICS IN PEDIATRIC INFLAMMATORY BOWEL DISEASES: A NEW BASIS FOR SERUM MARKERS DISCOVERY Membrane remodeling and its role in malaria parasite infection and pathogenesis Functional and structural changes induced by repetitive transcranial magnetic stimulation on corticostriatal pathway in models of Parkinson s disease and dyskinesia SAN RAFFAELE PISANA ORD Brain Disorders and 8, Toscana ORD Oncology 2 8, Abruzzo ORD Biological Chemistry and Macromolecular Biophysics 8, SAN MATTEO EST Oncology 2 8, Lombardia ORD Brain Disorders and 8, Veneto ORD Digestive, Kidney 8, and Urological Systems Istituto Superiore di Sanita' EST Infectious Diseases 8, and Microbiology SANTA LUCIA ORD Brain Disorders and 8, Pagina 36 di 332

37 The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 8, Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies Hyperthophic cardiomyopathy: new insights from deep sequencing and psycosocial evaluation. Development of new peptide mimetic compounds and small organic molecules targeting the ErbB3/p85 interaction to improve ErbB2 overexpressing metastatic breast cancers therapy Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome RIZZOLI ORD Cell Biology 8, Lombardia CLI COF Cardiovascular and 8, Respiratory REGINA ELENA EST Oncology 1 Basic 8, GASLINI EST Oncology 1 Basic 8, Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 8, Paraganglioma syndrome associated with succinate dehydrogenase defects: toward the discovery of biomarkers and novel pharmacological therapies MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL I. O. V. ORD Oncology 1 Basic 8, Toscana CLI ORD Infectious Diseases 8, and Microbiology Pagina 37 di 332

38 Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow up ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA Integration of advanced molecular analyses and magnetic resonance imaging for the identification of biomarkers of disease progression in multiple sclerosis. Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis Anosognosia in preclinical and clinical Alzheimer disease as early marker of illness outcome prediction: impact of precocious clinical diagnosis and rehabilitative intervention Disentangling endogenous resident adult cardiac stem cell biology and aging for clinical protocols of myocardial regeneration without cell transplantation REGINA ELENA ORD Oncology 1 Basic 8, Emilia Romagna CLI ORD Brain Disorders and 8, FATEBENEFRATELLI EST Immunology 8, (4) SDN ORD Molecular, Cellular, 8, and Developmental Istituto Superiore di Sanita' ORD Brain Disorders and 8, HUMANITAS ORD Immunology 8, SANTA LUCIA CLI ORD Brain Disorders and 8, Calabria ORD Cardiovascular and 8, Respiratory Pagina 38 di 332

39 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 8, Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS ROLE OF RIBOFLAVIN TRANSPORTERS IN MOTOR NEURON DISEASES: Genetic analysis of the Brown Vialetto Van Laere and Fazio Londe syndromes and development of potential treatment strategies for motor neuron diseases. Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches Piemonte ORD Molecular, Cellular, 8, and Developmental MAGGIORE ORD Molecular, Cellular, 8, and Developmental SAN MATTEO ORD Biological Chemistry and Macromolecular Biophysics 8, Generation of artificial lymphoid organs with mutipotent stromal progenitors derived from induced pluripotent stem cells. SAN RAFFAELE MONTE TABOR ORD Biology of 8, Development and Aging MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS Perinatal life threatening arrhythmias and Sudden Infant death MAGGIORE ORD Genes, Genomes and Genetics 8, SAN MATTEO ORD Genes, Genomes 8, and Genetics Empowering the brain. Induction of Hebbian like plasticity in cortico cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients Lazio EST Brain Disorders and 8, (4) Pagina 39 di 332

40 Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 8, Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 8, Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano CLI ORD Oncology 2 8, Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA CLI ORD Brain Disorders and 8, MEF promotes stemness in the pathogenesis of gliomas FATEBENEFRATELLI ORD Oncology 1 Basic 8, Congenital Myopathies: genetic screening starting from a new diagnostic algorithm OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 8, (4) Oral and Skin Development of beta cell specific aptamers as novel diagnostic and therapeutic tools for diabetes mellitus. SAN RAFFAELE MONTE TABOR ORD Surgical, Biomedical Imaging, and Bioengineering 8, A machine learning approach to pharmacogenomics. Application to therapy of autoimmune diseases, Myastenia Gravis and Multiple Sclerosis. CARLO BESTA CLI ORD Genes, Genomes 8, and Genetics Pagina 40 di 332

41 EVALUATION OF HUMAN ADIPOSE TISSUE DERIVED STROMAL CELLS FOR THE TREATMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS SAN RAFFAELE PISANA EST Endocrinology, Metabolism, Nutrition and Reproductive 8, Targeting strategies in Numb defective cancers I.E.O. ORD Oncology 1 Basic 8, DESIGNING MOLECULAR CHAPERONS FOR PROTEINS: A NEW STRATEGY FOR DRUG DISCOVERY IN NEURODEGENERATIVE DISEASES INNOVATIVE METHOD FOR THE TREATMENT OF TOTAL LIMBAL STEM CELLS DEFICIENCY (LSCD) THROUGH A TISSUE ENGINEERED HEMICORNEA Targeting myeloid cells with novel nanotechnology based platforms to control metastatic disease The use of an innovative microarray platform into the clinical setting DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' ORD Molecular, Cellular, 8, and Developmental Veneto CLI ORD Bioengineering 8, and Technologies Veneto EST Oncology 1 Basic 8, Sicilia ORD Genes, Genomes 8, and Genetics Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 8, Investigating KAP1 mediated epigenetic control of differentiation and function of adaptive immune system SAN RAFFAELE MONTE TABOR ORD Immunology 8, Pagina 41 di 332

42 CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY:A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' ORD Immunology 8, Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy Emilia Romagna ORD Immunology 8, NEUROLESI ORD Brain Disorders and 8, HUMANITAS ORD Oncology 1 Basic 8, Redox dysfunctions in autoinflammatory syndromes. Role in disease course, novel therapeutic approaches IRCCS AOU San Martino IST (Genova) ORD Immunology 8, Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 8, and Genetics SPES Service for detection of Pre psychoses: from gene environment interactions to phenomenology TARTEGED TREATMENT OF HAIRY CELL LEUKEMIA MEDEA ORD Brain Disorders and 8, Umbria CLI ORD Oncology 2 8, Pagina 42 di 332

43 Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Istituto Superiore di Sanita' CLI ORD Infectious Diseases and Microbiology 8, Toscana CLI ORD Cardiovascular and 8, Respiratory Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 8, Hypertension in high school students: Genetic and Environmental Factors Toscana CLI EST Population 8, and Epidemiology Role of Ezh2 in DNA damage response REGINA ELENA EST Oncology 1 Basic 8, Regulation of cancer stem cell symmetric divisions by myc A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. I.E.O. EST Oncology 1 Basic 8, MAGGIORE CLI ORD Brain Disorders and 8, Search for new genes and new therapies for Neonatal Diabetes Mellitus (NDM) and Hyperinsulinism and Hypoglycemia (HH). OSPEDALE BAMBINO GESU' CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 8, Pagina 43 di 332

44 Purinergic modulation of SDF 1/CXCR4 directed endothelial and cardiac progenitors cell functions: theraupetic potential in cardiovascular regeneration. Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms The role of macrophages in Primary Biliary Cirrhosis: novel targets for immune intervention SAN RAFFAELE PISANA ORD Cardiovascular and 8, Respiratory AUXOLOGICO ORD Genes, Genomes 8, and Genetics HUMANITAS EST Immunology 8, Heterotypic interactions in thromboinflammatory processes associated with the TABOR SAN RAFFAELE MONTE thrombotic vascular occlusion in sepsis: the role of vitamin K dependent protein C ORD Vascular and 8, Hematology Supporting an early autism spectrum disorders diagnosis through the support vector machine approach The Lausanne Trilogue Play used as a psychodiagnostic and therapeutic tool in a Neuropsychiatric Unit: an innovative clinical experience working with psychitric children and adolescent The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] STELLA MARIS CLI ORD Brain Disorders and Veneto CLI ORD Risk, Prevention and Health Behavior Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering Lazio CLI ORD Cardiovascular and Respiratory Pagina 44 di 332

45 Porous titanium combined with an osteoinductive hydrogel and cells: an innovative strategy to improve prosthetic implants osteointegration Exercise and inflammation in obesity. Evaluation of relationships and possible interventions. (ObInEx Project) Manufacturing information of orthopedic articular prosthesis. Analysis of specific safety issues for radiotherapy, magnetic resonance, orthopedic surgery and identification of a traceability model. CERVICAL PLETHYSMOGRAPHY: A NEW TOOL FOR NON INVASIVE ASSESSMENT OF CEREBRAL VENOUS RETURN, AND A POSSIBLE SCREENING DEVICE FOR CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY Assessing the effect of an intensive rehabilitation treatment(irt) on neurotrophic factors production in patients with Parkinson s disease Systematic review on the interventions to reduce waiting lists for elective procedures GALEAZZI COF Musculoskeletal, Oral and Skin DON GNOCCHI ORD Endocrinology, Metabolism, Nutrition and Reproductive Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Emilia Romagna CLI COF Vascular and Hematology MAUGERI ORD Brain Disorders and Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto CLI ORD Infectious Diseases and Microbiology Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano CLI ORD Healthcare Delivery and Methodologies Pagina 45 di 332

46 From NAFLD to HCC: mouse model and definition of predisposing and prognostic factors for human liver disease management. Marche ORD Digestive, Kidney and Urological Systems Early Detection in Autism Spectrum Conditions STELLA MARIS CLI ORD Brain Disorders and BORON NEUTRON CAPTURE THERAPY (BNCT) IN CUTANEOUSRECURRENCES OF BREAST CANCER: THE DIAGNOSTIC AND THERAPEUTICUTILITY OF 18F FBPA PET/CT PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Radiolabelled nanoparticles as radiopharmaceuticals for preclinical drug development with molecular imaging in angiogenesis Biochemical markers of brain damage following epileptic seizures in children and correlation with cognitive outcome and quantitative imaging data DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER2+ cancer patients MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR CLINICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME I. O. V. CLI ORD Oncology Lombardia CLI ORD Risk, Prevention and Health Behavior Toscana ORD Bioengineering and Technologies Toscana CLI EST Brain Disorders and Piemonte ORD Oncology HUMANITAS CLI ORD Integrative, Functional, and Cognitive Pagina 46 di 332

47 A randomized controlled trial of diet and physical activity in BRCA mutation carriers ISTITUTO TUMORI MILANO CLI ORD Risk, Prevention and Health Behavior IDENTIFICATION AND VALIDATION OF NEW THERAPEUTIC TARGETS FOR MULTIPLE MYELOMA PATIENTS Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery Emilia Romagna EST Oncology 1 Basic SANTA LUCIA CLI ORD Brain Disorders and IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA CLI ORD Healthcare Delivery and Methodologies Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche CLI ORD Population and Epidemiology MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO ORD Oncology 1 Basic Pharmacological treatments plus mesenchymal stem cell transplantation as novel therapeutic approach in cerebral ischemia Epigenetic remodeling of ncx1 gene by drugs inhibiting histone deacetylases (HDACs) class I: a new strategy to reduce the neuronal damage in brain ischemia Toscana ORD Brain Disorders and SDN ORD Brain Disorders and Pagina 47 di 332

48 Deciphering the genetic complexity of myeloproliferative neoplasms and the molecular pathways involved in disease progression Effect of proteasome and VEGF receptor inhibitors on NKG2D ligand expression on hepatocellular carcinoma cells: implications for immunotherapy of liver cancer. Human Well Being: a Twin Study on the Relation between Optimal Psychological and Biological Functioning SAN MATTEO ORD Vascular and Hematology SAN MATTEO ORD Oncology Istituto Superiore di Sanita' ORD Biobehavioral and Behavioral Processes Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering Dual ErbB 3 and PI3K/AKT pathway inhibition as a novel approach to targeting cancer Abruzzo EST Oncology CHANGES IN STRUTTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS NEURONAL POTASSIUM CHANNEL KV3.4 AS A NON TRADITIONAL MOLECULAR TARGET FOR THE DEVELOPMENT OF DRUGS PREVENTING NEURONAL CELL DEATH IN ALZHEIMER DISEASE SANTA LUCIA ORD Integrative, Functional, and Cognitive SAN RAFFAELE PISANA ORD Molecular, Cellular, and Developmental Muscle fibrosis in DMD: Molecular characterization with a new human in vitro model and therapeutic approach CARLO BESTA ORD Musculoskeletal, Oral and Skin Pagina 48 di 332

49 Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Role of trace element in the pathogenesis of Multiple sclerosis Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells Diagnosis of attention deficit/hyperactivity disorder (ADHD) in adults by quantitative EEG and transcranial magnetic stimulation markers. Polymeric films and magnetic forces for gallbladder retraction during a fully translumenal cholecystectomy Lazio CLI ORD Population and Epidemiology Istituto Superiore di Sanita' ORD Population and Epidemiology MONZINO ORD Cardiovascular and Respiratory OASI MARIA S.S. ORD Biobehavioral and Behavioral Processes Piemonte ORD Surgical, Biomedical Imaging, and Bioengineering Pre clinical assessment of innovative treatments against malignancies based on micrornas ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Oncology Targeting neuroprotective endogenous neural stem cells in stroke A WEB based, paperless and open source implementation of IHE radiological and nuclear medicine workflow SANTA LUCIA CLI EST Brain Disorders and Veneto ORD Healthcare Delivery and Methodologies Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary (5) Pagina 49 di 332

50 Next generation seqencing technologies applied to mantle cell lymphoma: a tool to understand its pathogenesis and to identify novel biomarkers and therapeutic approaches Veneto ORD Oncology 1 Basic Revealing brain mechanisms of Chronic Subjective Dizziness Mitochondrial Carrier Diseases: prevalence, study of pathogenetic mechanisms, and possible therapies A Janus role of autophagy in Cystic Fibrosis: a new therapeutic approach? Obesity associated Flt3 mutations in Acute Promyelocytic Leukemia: investigating a novel paradigm for the cancer promoting effect of obesity IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER MicroRNAs as molecular biomarkers for early detection of sporadic Fronto temporal Dementias Role of IBtk, a B cell signalling regulator, in cancer development. SANTA LUCIA ORD Integrative, Functional, and Cognitive STELLA MARIS ORD Brain Disorders and Istituto Superiore di Sanita' ORD Cardiovascular and Respiratory I.E.O. ORD Oncology 1 Basic Emilia Romagna CLI ORD Digestive, Kidney and Urological Systems SDN CLI ORD Digestive, Kidney and Urological Systems Umbria ORD Brain Disorders and Calabria ORD Cell Biology Pagina 50 di 332

51 GENETIC SUSCEPTIBILITY AND PHARMACOGENETICS OF MULTIPLE MYELOMA AND MGUS Toscana ORD Oncology 1 Basic Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer s Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an in vitro model of anesthetic inducing oligomerization Molecular mechanisms of neutrophil recruitment as novel targets to curb lung damage in cystic fibrosis. Characterization of the genomic architecture of myelodysplastic syndromes and definition of a molecular basis for their classification and prognostication NEUROLESI ORD Brain Disorders and Abruzzo ORD Cardiovascular and Respiratory SAN MATTEO ORD Oncology 1 Basic New tools to identify effective SMA therapeutics: a protein fragment complementation assay coupled to snrnp biogenesis to measure the SMN complex activity in SMA cells SANTA LUCIA ORD Genes, Genomes and Genetics Defining non invasive outcome measures and elucidating the molecular mechanisms underlying muscle degeneration in Facioscapulohumeral muscular dystrophy DON GNOCCHI ORD Musculoskeletal, Oral and Skin DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Pagina 51 di 332

52 Role of mirnas in inflammatory synaptopathy in a mouse model of MS Role of Chromatin Remodeling in Epigenetic Cell Memory SANTA LUCIA ORD Brain Disorders and SANTA LUCIA ORD Genes, Genomes and Genetics Aberrant choline metabolism in ovarian cancer as a source of multilevel data in prognosis and/or therapeutic guidance. ISTITUTO TUMORI MILANO ORD Oncology ADVANCED CLINICAL AND MOLECULAR EFFORTS IN HEREDITARY SPASTIC PARAPLEGIA An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification PKC beta as new target to prevent pharmacologically induced weight gain during antipsychotic treatment. HIGH THROUGHPUT TECHNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC MARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) STELLA MARIS ORD Brain Disorders and MONZINO ORD Brain Disorders and Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive Puglia ORD Digestive, Kidney and Urological Systems RAPAMYCIN PLUS DPPIV INHIBITOR IN IMPROVING BETA CELL FUNCTION IN LONG STANDING TYPE 1 DIABETES: PROSPECTIVE RANDOMIZED TRIAL SAN RAFFAELE MONTE TABOR EST Endocrinology, Metabolism, Nutrition and Reproductive Pagina 52 di 332

53 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice MONDINO ORD Molecular, Cellular, and Developmental MONDINO CLI ORD Healthcare Delivery and Methodologies FATEBENEFRATELLI ORD Brain Disorders and Characterizations of the anti Tat adaptative immune responses in individuals naturally controlling HIV 1 replication SAN RAFFAELE MONTE TABOR ORD AIDS and Related Research Dissecting the CLL lipidome in search for novel SAN RAFFAELE MONTE prognostic markers and targets for tailored therapy TABOR ORD Oncology Normalization of defective calcium handling in cardiac pathologies: innovative strategies and potential therapeutical applications The impact of local sleep on awake human behavior Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non invasive biomarkers in colon and rectal cancer HUMANITAS ORD Cardiovascular and Respiratory Toscana EST Integrative, Functional, and Cognitive I. O. V. ORD Oncology Genetic characterization of supraventricular arrhythmias by whole exome sequencing SAN RAFFAELE MONTE TABOR ORD Cardiovascular and Respiratory Pagina 53 di 332

54 Pathogenesis of congenital human cytomegalovirus infection SAN MATTEO ORD Infectious Diseases and Microbiology THE ROLE OF CALCIUM HOMEOSTASIS IN DEVELOPMENTAL ATAXIAS: genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ ATPase. OSPEDALE BAMBINO GESU' ORD Molecular, Cellular, and Developmental Cdk5 in tumor progression. HUMANITAS ORD Oncology 1 Basic Surviving ER stress: lessons from a CMT1B neuropathy model SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, and Developmental A combination of surveys, spatial analyses and molecular epidemiology to get an insight of preharvest risks from Shiga toxin producing Escherichia coli. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary (5) Role of the microbiota and peripheral biomarkers in weight restoration and weight maintenance in patients with Anorexia Nervosa. FATEBENEFRATELLI ORD Brain Disorders and MODULATING NEUREGULIN 1 SIGNALS TO TREAT HEREDITARY DEMYELINATING NEUROPATHIES SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, and Developmental Investigation of brain functional connectivity by graph based network analysis: application to normal ageing and prodromal Alzheimer s disease. CARLO BESTA ORD Brain Disorders and Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment FATEBENEFRATELLI ORD Biobehavioral and Behavioral Processes Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE PISANA ORD Infectious Diseases and Microbiology Pagina 54 di 332

55 Role of Che 1 in DNA damage response REGINA ELENA ORD Oncology 1 Basic Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders Targeting altered proton dynamics of sarcomas as an effective therapeutic tool Novel multi scale approach to 3d cancer models for the discovery of new therapeutic strategies for bone metastases Nanometer size Gold Clusters Bioconjugates for Efficient Drug Delivery Predictive factors of response to therapies in colorectal and breast cancers. Longitudinal clinical neuropsychological study of subjective memory complaints Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease Innovation, education and treatment of drug abuse with dual diagnosis (INNUENDO) Dissecting host parasite interactions by RNA interference knock down of erythrocyte membrane microdomain proteins SANTA LUCIA ORD Integrative, Functional, and Cognitive RIZZOLI ORD Oncology GALEAZZI EST Oncology 1 Basic C.R.O. AVIANO EST Oncology MAUGERI ORD Oncology 1 Basic 9, Toscana CLI ORD Brain Disorders and 9, MAUGERI CLI ORD Brain Disorders and 9, Abruzzo CLI EST Risk, Prevention 9, and Health Behavior Istituto Superiore di Sanita' ORD Infectious Diseases 9, and Microbiology Pagina 55 di 332

56 Extracellular iron as a key signal in muscle necrosis and regeneration SAN RAFFAELE MONTE TABOR EST Immunology 9, EXACT EXPLORING ACTIONS: A FUNCTIONAL APPROACH TO DECODE REPRESENTATION OF MOTOR ACTS IN THE HUMAN BRAIN Toscana ORD Biobehavioral and 9, Behavioral Processes Gene identification in rare genetic disorders affecting lysosomal degradation pathways in skeletal muscle. Role of HIV 1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies Gene environment interaction in top down regulation of compulsive eating: a translational study of food addiction CARLO BESTA EST Musculoskeletal, 9, Oral and Skin Istituto Superiore di Sanita' EST AIDS and Related 9, Research SANTA LUCIA ORD Brain Disorders and 9, Role of hypoxia induced mir 210 in tissue response to peripheral ischemia ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Vascular and 9, Hematology Role of DNA methylation in diagnosis and prognosis of prostate cancer. Improved pre surgical evaluation of the human epileptogenic zone with a novel intracranial recording/analysis platform Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Piemonte ORD Oncology 1 Basic 9, CARLO BESTA COF Brain Disorders and 9, Emilia Romagna CLI ORD Population 9, and Epidemiology Pagina 56 di 332

57 Effects of testosterone supplementation on erythropoiesis: potential therapeutic implications in the anemia of older patients Emilia Romagna CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 9, Prostacyclin in microsurgical flaps. Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering 9, Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Evaluation of extrapyramidal involvement in amyotrophic lateral sclerosis (ALS): a prospective cohort survey Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Functional significance of manipulating endogenous neurogenesis for nigrostriatal dopaminergic neuroprotection/neurorepair in murine models of Parkinson s disease: focus on neuroinflammation HIV 1 Tat interaction with host microrna regulatory network: implications for immune dysregulation Sorafenib as Adjuvant Treatment in the Prevention Of Recurrence of Hepatocellular Carcinoma Control of telomeric DNA topology in normal and cancer cells Emilia Romagna CLI ORD Oncology 2 9, Piemonte CLI ORD Brain Disorders and 9, Friuli Venezia Giulia CLI ORD Healthcare Delivery 9, and Methodologies OASI MARIA S.S. ORD Brain Disorders and 9, Calabria ORD AIDS and Related 9, Research Emilia Romagna ORD Oncology 2 9, REGINA ELENA ORD Cell Biology 9, Pagina 57 di 332

58 The role of T cells in postmenopausal bone loss: Piemonte EST Immunology 9, focus on autoreactive T cells in peripheral blood of patients affected by severe form of osteoporosis THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia CLI ORD Brain Disorders and 9, Adverse Health Effects of Airborne Particle Pollution: a multidisciplinary study IRCCS AOU San Martino IST (Genova) ORD Population 9, and Epidemiology Smoke and uremic toxins activate the aryl hydrocarbon receptor pathway in monocytes: relevance for the development of abdominal aortic aneurysm. IRCCS AOU San Martino IST (Genova) ORD Vascular and 9, Hematology Application of multilocus sequence typing (MLST) for surveillanceof Candida infections in hospital care units and use of PCR based methodologies to determine the frequency and distribution of emerging new cryptic Candida species. NEUROLESI ORD Infectious Diseases 9, and Microbiology ROLE OF THE DNAM 1/PVR PATHWAY IN THE PATHOGENESIS OF HIV 1 INFECTION OSPEDALE BAMBINO GESU' EST AIDS and Related 9, Research Disease related biomarkers investigation in Multiple sclerosis by analysis of microvesicles isolated by CSF. Reactive oxygen species (ROS) and phosphoinositide 3 kinase (PI3K) signalling in breast cancer Whole genome scanning in AML to develop a better prognostic stratification and personalized risk based therapies Sicilia ORD Molecular, Cellular, 9, and Developmental Abruzzo EST Oncology 1 Basic 9, SAN MATTEO ORD Oncology 2 9, Pagina 58 di 332

59 Role of sphingolipids in white matter dysfunctions in neurodegenerative disorders NEUROMED ORD Brain Disorders and 9, CENTRAL EFFECTS OF BOTULINUM NEUROTOXINS: THERAPEUTIC IMPLICATIONS Toscana ORD Brain Disorders and 9, Necdin role in myogenic stem cells self renewal and maintenance for the repair of the dystrophic muscle SAN RAFFAELE MONTE TABOR ORD Musculoskeletal, 9, Oral and Skin Study of the involvement of the microbiota in intestinal tumorigenesis: emphasis on APC gene regulation. EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: CLINICAL/REHABILITATIVE IMPLICATIONS FOR DISORDERS OF SPATIAL ATTENTION IN STROKE PATIENTS I.E.O. ORD Oncology 1 Basic 9, SANTA LUCIA CLI ORD Brain Disorders and 9, DEFINING INNOVATIVE TREATMENT STRATEGIES FOR OSTEOSARCOMA BASED ON THE INHIBITION OF ABC TRANSPORTERS AND PROTEIN KINASES RIZZOLI ORD Oncology 2 9, Robotic Therapy for balance recovery and evaluation in pediatrics OSPEDALE BAMBINO GESU' EST Integrative, Functional, and Cognitive 9, Individualized treatment of patients with advanced NSCLC: potential application for Circulating Tumor Cells (CTC) molecular and phenotypical profiling I. O. V. CLI ORD Oncology 2 9, Pagina 59 di 332

60 Corrected ipsc as therapeutic source for Spinal Muscular Atrophy Intrauterine growth restriction. and proteo metabolomic investigation. FEASIBILITY AND COST EFFECTIVENESS OF A MULTIDISCIPLINARY HOME TELEHEALTH INTERVENTION PROGRAMME TO REDUCE FALLS AMONG ELDERLY DISCHARGED FROM HOSPITAL: A PILOT RANDOMIZED CONTROLLED TRIAL Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Role of squamous cell differentiation regulators in lung cancer. Molecular understanding of E3 ligases involved in signaling and cancer The neurobiology of social perception deficits in Autism Spectrum Disorders: simulation, integration and connectivity In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies MAGGIORE ORD Molecular, Cellular, 9, and Developmental Veneto ORD Endocrinology, Metabolism, Nutrition and Reproductive 9, MAUGERI CLI ORD Risk, Prevention 9, and Health Behavior Toscana CLI ORD Healthcare Delivery 9, and Methodologies SDN EST Musculoskeletal, 9, Oral and Skin I.E.O. ORD Biological Chemistry and Macromolecular Biophysics 9, Abruzzo ORD Brain Disorders and 9, Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 9, Pagina 60 di 332

61 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 9, BASAL GANGLIA FUNCTIONAL ABNORMALITIES CORRELATING WITH GAIT DISTURBANCES IN PARKINSON S DISEASE. TOWARD NOVEL BRAIN SIGNAL CONTROLLED DEVICES FOR ADAPTIVE DEEP BRAIN STIMULATION Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Strategies To Improve Human Cardiac Stem Cell Regenerative Capacity MAGGIORE ORD Brain Disorders and 9, Toscana ORD Oncology 2 9, Lazio ORD Cardiovascular and 9, Respiratory Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary 9, (5) Role of TIR8, a novel member of IL 1R/TLR family with a negative regulatory activity, in inflammation and cancer. Screening of children at risk for language and communication disorders Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. HUMANITAS ORD Immunology 9, Lazio CLI ORD Biobehavioral and 9, Behavioral Processes OASI MARIA S.S. ORD Interdisciplinary 9, Molecular and Training Pagina 61 di 332

62 Role of the master stroma regulator SPARC in myeloid cancer associated bone marrow failure. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 9, A CORRELATIVE, NEUROIMMUNOVIROLOGICAL AND MRI ANALYSIS OF PROGNOSTIC MARKERS IN ALZHEIMER'S DISEASE DON GNOCCHI ORD Brain Disorders and 9, Dominant optic atrophy (DOA) and OPAopathies in Italy: prevalence, phenotypes, genes and functional studies towards a therapy Istituto Scienze Neurologiche ORD Brain Disorders and 9, Soluble biomarkers predicting coronary bypass graft patency Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. MONZINO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 9, Veneto ORD Genes, Genomes 9, and Genetics Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA ORD Brain Disorders and 9, Circulating tumor cells, with stem like and/or epithelial mesenchymal transition features, detectable in peripheral blood of breast cancer patients: biological and clinical significance ISTITUTO TUMORI MILANO ORD Oncology 2 9, New antimicrobial agents targeting antibiotic resistance mechanisms and novel or underexploited targets Cyclophilin A as a new therapeutic target for limb ischemia Marche ORD Infectious Diseases and Microbiology 9, MONZINO ORD Vascular and 9, Hematology Pagina 62 di 332

63 Quantitative assessment of spasticity: physiopathology and clinical application SANTA LUCIA CLI EST Biobehavioral and 9, Behavioral Processes MOLECULAR TECHNIQUES FOR MONITORING THE RESPONSE TO THERAPY IN TUBERCULOSIS PATIENT SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 9, and Microbiology TISSUE PATCH ENGINEERING OF ADIPOSE DERIVED STEM CELLS FOR MEDICAL DEVICES. From observation to action in dementia prevention to identify prognostic and intervention monitoring tools based on non invasive multimarkers phenotypes MAGGIORE ORD Bioengineering 9, and Technologies Umbria ORD Biobehavioral and 9, Behavioral Processes Sirt1 and Sirt2 as targets for the manipulation of the proliferative processes associated to physiopathologic conditions of the skin ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 9, Oral and Skin IDENTIFICATION OF PHENOTYPE MODULATOR VARIANTS IN LAMIN A/C MUTATION CARRIERS BY EXOME AND GENOME SEQUENCING SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 9, and Genetics Oxidative stress and microrna 125b : from molecular mechanisms to therapeutic implications in Hailey Hailey disease Istituto Superiore di Sanita' ORD Musculoskeletal, 9, Oral and Skin Optimization of the clinical management of endocrine responsive early breast cancer patients IRCCS AOU San Martino IST (Genova) CLI ORD Oncology 2 9, Assessing the immunomodulatory effect of probiotics in the Experimental Model of Myasthenia Gravis CARLO BESTA EST Brain Disorders and 9, Pagina 63 di 332

64 Strategy of immunotherapy with specific T lymphocytes versus B cell acute lymphoblastic leukemia Role of Calcium/Calmodulin dependent Kinase Kinase 2 in metabolic stress and inflammatory response Prognostic utility of biological indicators in human colorectal cancer: the chemokine axis CX3CL1/CX3CR1 Piemonte ORD Oncology 2 9, SAN RAFFAELE PISANA ORD Immunology 9, HUMANITAS ORD Oncology 1 Basic 9, Food irradiation: quality and detection of plant origin food with health benefits Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Veterinary 9, (5) Role of HIV p17 in EBV driven B cell lymphomagenesis C.R.O. AVIANO ORD Oncology 1 Basic 9, Understanding and enhancing the therapeutic effect of FTY720 (Fingolimod) in multiple sclerosis: a structural biology approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 9, MOLECULAR PROFILING OF HEPARAN SULFATES IN M.O. PATIENTS: EVALUATION OF PATHOPHYSIOLOGICAL PATHWAYS TO DEFINE A COMPLETE CHEMICAL PROFILING FOR DIAGNOSIS AND PATIENTS FOLLOW UP. RIZZOLI ORD Biological Chemistry and Macromolecular Biophysics 9, Ageing at work: promoting health and safety of ageing workers according to changes of demography, labour market and social policies. MAGGIORE ORD Risk, Prevention 9, and Health Behavior Neural Stem Cell mediated Therapy of Amyotrophic Lateral Sclerosis CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 9, Pagina 64 di 332

65 mtor substrate and microrna involvement in ALS: potential novel therapeutic perspectives and pathological markers. SANTA LUCIA ORD Brain Disorders and 9, Pathway Dissection In Leukocyte Migration: SAN RAFFAELE MONTE Identification And Validation Of Novel TABOR Therapeutic Targets In Nonresolving Inflammation ORD Immunology 9, Telemedicine Services for UTAP Veneto CLI ORD Healthcare Delivery 9, and Methodologies A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 9, (5) HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets Autoimmunity to PDGF receptor and DNA instability: a novel pathogenic mechanism with implications for new diagnostic and therapeutic tools in fibrotic diseases Epigenetic memory and impairment of human endothelial and mesenchymal progenitor activity by cardiovascular risk factors The role of Ambra1 mediated autophagy in the development and prognosis of gliomas. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 9, PASCALE CLI ORD Oncology 2 9, Marche EST Immunology 9, MONZINO ORD Cardiovascular and 9, Respiratory SANTA LUCIA ORD Oncology 1 Basic 9, Pagina 65 di 332

66 Molecular biomarkers and cellular biosensors of neurodegeneration SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 9, The role of epigenome in lamin disorders: higher order structures in time and space An integrated genomic and immunologic approach to novel strategies of monitoring and therapy for HBV and HCV infections SANTA LUCIA ORD Cell Biology 9, Emilia Romagna ORD Infectious Diseases 9, and Microbiology Identification of prognostic and predictive serum biomarkers for monitoring type 1 diabetes risk and progression in humans Toscana ORD Immunology 9, The key role of serotonin in the pathophysiology of phenylketonuria: from bench to bedside OASI MARIA S.S. ORD Brain Disorders and 9, New molecular pathways involved in coronary and carotid atherosclerosis SAN RAFFAELE MONTE TABOR EST Vascular and 9, Hematology EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF DIFFERENT MEMORY TESTS FOR ALZHEIMER S DISEASE SAN RAFFAELE MONTE TABOR CLI EST Brain Disorders and 9, EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO CLI ORD Healthcare Delivery 9, and Methodologies Prognostic marker of cytomegalovirus infection and transmission in pregnancy. ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna CLI ORD Infectious Diseases 9, and Microbiology Emilia Romagna CLI ORD Brain Disorders and 9, Pagina 66 di 332

67 Vitamin D and Myasthenia Gravis: from the animal model to the human disease CARLO BESTA ORD Brain Disorders and 9, Application of nanomechanical assays to detection of algal toxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 9, CNF1 as a new therapeutic approach for the treatment of astrogliosis and neuroinflammation in Alzheimer's disease SENSITIZING GLIOBLASTOMA CELLS TO CHEMOTHERAPY BY PRO DIFFERENTIATING AGENTS Istituto Superiore di Sanita' ORD Brain Disorders and 9, Veneto ORD Oncology 1 Basic 9, A study on molecular characteristics of the gp120 Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Istituto Superiore di Sanita' ORD AIDS and Related 9, Research An innovative machine perfusion (Bologna machine perfusion) for abdominal organs preservation before transplantation. Optimization of perfusion, temperature and oxygenationrelated variables. An intervention aimed at improving the cognitive, physical, and psychiatric functioning of patients with Mild Cognitive Impairment: A randomized control trial of physical exercise and cognitive stimulation. Developmental Dyslexia Prevention: Magnocellular Dorsal Pathway Deficit Identification by Means of Visual Motion Illusions and Perceptual Learning Training Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 9, Lazio CLI ORD Risk, Prevention 9, and Health Behavior MEDEA CLI ORD Brain Disorders and Pagina 67 di 332

68 HPV INFECTION IN A COHORT OF HIV POSITIVE MEN AND WOMEN: VIRO IMMUNOLOGICAL CORRELATES OF HPV DISEASE PROGRESSION AT GENITAL AND ORAL SITES Non invasive diagnosis on non alcoholic steatohepatitis and of significant/severe fibrosis among patients with non alcoholic fatty liver disease. Short term effects of the implementation of the NIDCAP model for very low birth weight babies Lombardia CLI ORD AIDS and Related Research Sicilia CLI ORD Digestive, Kidney and Urological Systems Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying inherited thombophilias. A family study CASA SOLLIEVO SOFFERENZA ORD Population and Epidemiology EFFECT OF DEACETILASE INHIBITORS ON EPIGENETIC BALANCE OF E CADHERIN: NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Gastro intestinal bacteria, obesity and insulin resistance. Development of brain targeted epigenetic drugs for the treatment of neurodegenerative disorders and brain ischemia Piemonte ORD Oncology 1 Basic Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive S.CAMILLO COF Brain Disorders and Pagina 68 di 332

69 SURVEILLANCE OF MULTI DRUG RESISTANT (MDR) MICRO ORGANISM AND FUNGI COLONIZATION AND INFECTIONS ACQUIRED IN A NOSOCOMIAL SETTING, WITH PARTICULAR REFERENCE TO SURGICAL INFECTIONS IN CANCER PATIENTS AND EMERGENCY SURGERY PATIENTS. Telemedicine in cardiology:training of a virtual team Phenotypes in Dislexia with genetic alteration: sensory and neuronal deficits Development of a specific comorbidity index to improve the management of elderly MDS/AML patients Identification of novel determinants of therapeutic response to targeted therapies and of new druggable driver oncoproteins in patientderived xenografts from primary HER2 positive and triple negative breast cancers. Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia CLI EST Risk, Prevention and Health Behavior SAN RAFFAELE PISANA CLI ORD Healthcare Delivery and Methodologies STELLA MARIS CLI ORD Integrative, Functional, and Cognitive Piemonte CLI ORD Population and Epidemiology Piemonte ORD Oncology Sicilia CLI ORD Brain Disorders and Evaluation of the effect of testosterone replacement therapy (TRT) on prostatic gland in Toscana CLI ORD Endocrinology, Metabolism, hypogonadal patients affected by benign prostatic Nutrition and Reproductive hyperplasia (BPH) and metabolic syndrome (MetS) Biomarkers and prognostic factors in psoriasis and psoriatic arthritis: a prospective cohort study Lombardia CLI ORD Musculoskeletal, Oral and Skin Pagina 69 di 332

70 Impact of diet in shaping gut microbiota revealed by a prospective dietetic study of African children consuming a Western diet Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications DE BELLIS CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Emilia Romagna ORD Cardiovascular and Respiratory Transplantation of Human Amniotic Membrane Derived Mesenchymal Stem Cells (hamscs) for Hepatic Regeneration and Reduction of Fibrosis in Rats with Decompensated Cirrhosis Sicilia ORD Digestive, Kidney and Urological Systems A scoring system to predict the risk of developing post operative atrial fibrillation Heparin derivatives to regulate hepcidin expression and iron homeostasis Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Istituto Superiore di Sanita' ORD Cardiovascular and Respiratory FATEBENEFRATELLI ORD Vascular and Hematology Toscana ORD Infectious Diseases and Microbiology Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment of the neurocognitive and clinical outcomes of premature newborns SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and Amelioration of diagnosis and therapy of steroid resistant nephrotic syndrome: a novel treatment approach by umbilical cord blood mesenchymal stem cells. MAGGIORE CLI ORD Digestive, Kidney and Urological Systems Pagina 70 di 332

71 EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Target definition of tumors in positron emission tomography: development and validation of a software tool to be installed on radiotherapy treatment planning systems Cost Utility of Conventional Hemodialysis (CHD) versus Short Daily Hemodialysis (SDHD) for patients coming from Automated Peritoneal Dialysis (APD): A randomized controlled trial Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology Piemonte ORD Oncology Puglia CLI COF Healthcare Delivery and Methodologies Development and therapeutic potential evaluation of L glutamate and kynurenic acid analogues in an animal model of meningococcal meningitis. SDN ORD Infectious Diseases and Microbiology DOMoRIS Diabetes and Obesity Monitoring and Rehabilitation Integrated System AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Evaluation of oxidative stress and inflammation in blood as possible non invasive markers for progression of alcoholic liver disease. IRCCS AOU San Martino IST (Genova) ORD Digestive, Kidney and Urological Systems MicroRNAs as potential therapeutic strategies to prevent adverse vascular events and increase angiogenesis after limb ischemia. INVESTIGATING THE ROLE OF THE CERULOPLASMIN/TRANSFERRIN SYSTEM IN THE PHYSIOPATHOLOGY OF HEPATIC ENCEPHALOPATHY. Calabria ORD Cardiovascular and Respiratory SAN RAFFAELE PISANA ORD Brain Disorders and Pagina 71 di 332

72 Aphasia. Theory for therapy. Therapy for theory. S.CAMILLO CLI ORD Brain Disorders and Spatiotemporal organization of motoneuronal activity in the spinal cord in children with cerebral palsy SANTA LUCIA ORD Integrative, Functional, and Cognitive Autoimmune encephalopaties: better characterization of the antibody profile MARKERS TRANSLATIONAL PROGRAM IN THE ANTIANGIOGENIC TREATMENT OF COLORECTAL CANCER WITH BEVACIZUMAB Molecular characterization of glioblastoma stem cell contribution to tumor vascularization to design novel therapies for glioblastoma treatment Identification of micrornas as novel therapautic targets and biomarkers for the advancement of anti cancer strategies of human hepatocellular carcinoma Protective role of HspB8 in motor neuron diseases (MNDs) CARLO BESTA CLI ORD Brain Disorders and Toscana ORD Oncology Istituto Superiore di Sanita' ORD Oncology 1 Basic Emilia Romagna ORD Oncology MONDINO ORD Molecular, Cellular, and Developmental Pentraxin 3 as a predictive biomarker of NEUROMED CLI ORD Brain Disorders and hemorrhagic transformation following acute stroke Steroid myopathy: pathogenies and prevention MAUGERI ORD Musculoskeletal, Oral and Skin Pagina 72 di 332

73 Cancer biomarker detection using microstructured/super hydrophobic surfaces and advanced spectroscopy techniques Calabria COF Bioengineering and Technologies Role of SAMITAL in prevention of chemoradiation (CT/RT) induced oral mucositis in cancer patients. A Phase 2 Randomized Controlled trial in adults and a feasibility study in paediatric patients I. O. V. CLI COF Oncology Etiopathogenetic, diagnostic and prognostic role of hypermethylation and downregulation of IRX1 gene inducedby H. pylori infection in patients with gastric cancer. SAN RAFFAELE MONTE TABOR CLI ORD Oncology Innovative procedures for Transcranial Magnetic Stimulation of neuro patients, also in vegetative state NEUROLESI ORD Surgical, Biomedical Imaging, and Bioengineering NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Brain Disorders and The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson s Disease Implementation of a fracture liaison service for the identification, evaluation and management of patients with osteoporotic fractures Cell stress mediators in cancer stroma interaction as targets for drug development CHARACTERIZATION OF NEW MOLECULAR MECHANISMS CONTROLLING INVASIVENESS IN THYROID TUMORS OASI MARIA S.S. ORD Brain Disorders and Toscana CLI ORD Healthcare Delivery and Methodologies SDN ORD Oncology 1 Basic ARCISPEDALE ORD Oncology 1 Basic Pagina 73 di 332

74 GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS.EFFECT OF MUTATIONS OF APOB AND ANGPTL3 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer, cardiovascular diseases and neurodegenerative disorders in healthy subjects. Expression profile and risk haplotypes identification in peripheral blood of stroke patients with carotid atherosclerotic plaques AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR TREATMENT OF CHRONIC END STAGE LIVER DISEASE (ESLD) Exploring the effects of different intensity and frequency of robotic gait training in patients affected by a severe stroke in subacute phase In vivo identification of molecular determinants critical to the metastatic process in melanoma CANNABINOID AND GLUCOCORTICOID INTERACTION: A POSSIBLE BRIDGE OVER TROUBLED DISEASES Amniotic stem cells to improve congenital kidney damage: a fetal lamb model Emilia Romagna ORD Cardiovascular and Respiratory SAN RAFFAELE PISANA ORD Population and Epidemiology Veneto ORD Genes, Genomes and Genetics Emilia Romagna CLI ORD Digestive, Kidney and Urological Systems SANTA LUCIA CLI ORD Brain Disorders and I.E.O. ORD Oncology 1 Basic SANTA LUCIA ORD Brain Disorders and SAN MATTEO ORD Digestive, Kidney and Urological Systems Pagina 74 di 332

75 Susceptibility to heat in cohorts of births, children and elderly: a multi centric study to identify shortterm effects of heat, effect modifiers and to study long term exposure effects over a ten year period Lazio EST Population and Epidemiology Assessment of the diagnostic value of novel salivary and lachrymal biomarkers for the early non invasive diagnosis of primary Sjögren s syndrome The modulation of T helper cell death as therapeutic approach to reduce the pathogenic cells in Multiple Sclerosis (MS). Efficacy of re treatment with anti TNF biologics in patients with psoriasis who have been previously treated with the same biological drug Short and long term effects of ART in restoring intestinal mucosal immunity and reducing systemic immune activation in HIV infected patients. Development of a prognostic tool based on a systems biology approach to identify new predictive markers of the evolution of different diseases TIPS FOR DECOMPENSATED CIRRHOSIS: A RANDOMIZED CLINICAL TRIAL SMALL PEPTIDES AS A NEW STRATEGY FOR THE THERAPY OF CELIAC DISEASE Toscana EST Musculoskeletal, Oral and Skin SANTA LUCIA CLI ORD Brain Disorders and SAN GALLICANO ORD Musculoskeletal, Oral and Skin Istituto Superiore di Sanita' ORD AIDS and Related Research PASCALE ORD Oncology Sicilia CLI ORD Surgical, Biomedical Imaging, and Bioengineering Istituto Superiore di Sanita' ORD Digestive, Kidney and Urological Systems Pagina 75 di 332

76 In vivo analysis of the interactions between exogenouly administred mesenchymal stromal cells and primary acute leukemia cells or leukemia initiating cells growing in NOG mice: implications for selective delivery of anti cancer drugs to leukemic niches The Patatin like phospholipase domaincontaining3 (PNPLA3) I148M polymorphism in the recurrence of chronic hepatitis C after liver transplantation GASLINI ORD Oncology 1 Basic MAGGIORE CLI ORD Digestive, Kidney and Urological Systems Comprehensive analysis for identification of prognostic and predictive epigenetic signature in Renal Cell Carcinoma REGINA ELENA EST Oncology 1 Basic Isolation, characterization and pre clinical evaluation of cell derived microparticles as therapeutic tools in immunological and genetic disorders. OSPEDALE BAMBINO GESU' ORD Cell Biology Hydrogel Mesoangioblast combination therapeutic approach to ameliorate cell therapy effect on muscle dystrophy treatment. Obesity and inflammation: new mechanistic insights from whole exome sequencing and analysis of microrna regulation by polyphenols. SANTA LUCIA ORD Musculoskeletal, Oral and Skin Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive Role of HIF factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti leukemia therapy SAN RAFFAELE MONTE TABOR EST Oncology 1 Basic Comparative effectiveness of AVR and TAVI procedures for severe symptomatic aortic stenosis treatment: results from the real world Istituto Superiore di Sanita' CLI ORD Healthcare Delivery and Methodologies Pagina 76 di 332

77 How innate immunity enhances aggressiveness of colorectal carcinoma in HIV individuals SAN RAFFAELE MONTE TABOR ORD AIDS and Related Research PLERIXAFOR MOBILIZED HEMATOPOIETIC STEM CELLS: AN ALTERNATIVE STEM CELL SOURCE FOR GENE THERAPY OF BETA THALASSEMIA SAN RAFFAELE MONTE TABOR ORD Vascular and Hematology Identification of prognostic markers in advanced ovarian cancer by combining in vivo imaging with clinical and molecular data Lombardia CLI ORD Oncology Preemptive donor lymphocyte infusions guided by real time PCR host donor microchimerism for prevention of leukemia relapse after haploidentical stem cell transplantation SAN RAFFAELE MONTE TABOR CLI ORD Oncology Targeting Histone Acetylation as a Approach to Cancer Therapy Lysophosphatidic acid (LPA) as a lipid modulator of tumor/stroma cross talk during HCC tumor progression Identification of candidate modifier and causal genes for Multiple Osteochondromas by genomewide SNP/CNV genotyping REGINA ELENA EST Oncology ONCOLOGICO DI BARI EST Oncology 1 Basic RIZZOLI ORD Genes, Genomes and Genetics Thematic network on Bovine Diarrhoea Virus (BVDV) to improve tools and strategies for BVDV control in Italy Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary Non invasive stimulation of cerebello thalamocortical circuits in dystonic patients SANTA LUCIA CLI ORD Brain Disorders and Pagina 77 di 332

78 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive Study of pro inflammatory/anti inflammatory balance in Frontotemporal lobar degeneration FATEBENEFRATELLI ORD Brain Disorders and WNT signaling in the pathogenesis and treatment of Bipolar Disorder SAN RAFFAELE MONTE TABOR ORD Brain Disorders and Neurophysiological markers of neuroplasticity in normal and pathological aging FATEBENEFRATELLI ORD Brain Disorders and A new approach to diagnosis in muscular diseases CARLO BESTA EST Genes, Genomes and Genetics Toward a molecular criterium for the diagnosis of multiple Sclerosis.A proteomic and redox proteomic study Imaging and radioimmunotherapy of pancreatic cancer HOME BASED COGNITIVE REHABILITATION AFTER BRAIN DAMAGE THROUGH VIRTUAL REALITY Novel tools for evaluation of Type A aortic dissection: from bedside to bench, and back REGINA ELENA ORD Brain Disorders and I. O. V. ORD Surgical, Biomedical Imaging, and Bioengineering Lombardia CLI ORD Brain Disorders and NEUROMED CLI ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 78 di 332

79 MELANOMA TARGETING MULTIFUNCTIONAL NANOPARTICLES FOR THERAGNOSTIC APPLICATIONS ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Bioengineering and Technologies A new automatic device for personalized clinical monitoring of thrombotic and hemorraghic risk assessment in cancer patients Research Strategies for Treatment of Acute Neurodegenerative Disorders C.R.O. AVIANO COF Oncology CARLO BESTA EST Brain Disorders and A new therapeutic window in neurorehabilitation FATEBENEFRATELLI ORD Biobehavioral and Behavioral Processes Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenic brain malformation CARLO BESTA ORD Brain Disorders and Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary (5) A look into the intricate network of myospryn HUMANITAS ORD Cardiovascular and Respiratory Synapsin phosphorylation by PKA and Erk: role in learning related synaptic plasticity and schizophrenia related dopaminergic dysfunction MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model FATEBENEFRATELLI ORD Molecular, Cellular, and Developmental Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology Pagina 79 di 332

80 Effects of cognitive and aerobic training on cognitive performances and the resting state brain activity in aging individuals Abruzzo EST Biobehavioral and Behavioral Processes Pre clinical evaluation of safety and efficacy of intra arterial infusion of mesenchymal stems cells in experimental models of neurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial Targeting Sarcomas and Their Progenitors by Mesenchymal Stromal/Stem Cells Based Drug Delivery MONDINO ORD Brain Disorders and Emilia Romagna ORD Oncology Adoptive therapy with tolerogenic T regulatory type 1 (Tr1) cells in islet transplanted T1D patients SAN RAFFAELE MONTE TABOR ORD Immunology Targeting Hedgehog and Colony Stimulating Factor 1 pathways in triple negative breast cancers Toscana ORD Oncology Hypothesized points of convergence in the pathogenesis of Alzheimer's disease, frontotemporal lobar dementia, schizophrenia and bipolar disorder with therapeutic implications SAN RAFFAELE MONTE TABOR ORD Brain Disorders and Leptin, metabolic state and natural regulatory T cells: cellular and molecular basis for a novel immune intervention in multiple sclerosis Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. SANTA LUCIA CLI ORD Immunology SAN RAFFAELE PISANA ORD Infectious Diseases and Microbiology Pagina 80 di 332

81 WHOLE EXOME SEQUENCING TO IMPROVE DIAGNOSTIC, PROGNOSTIC AND LOGICAL CHARACTERIZATION OF AML WITH NORMAL KARYOTYPE Umbria ORD Vascular and Hematology Structural and functional large scale brain networks across multiple sclerosis clinical phenotypes: a graph theory approach to identify neuronal system vulnerability as a target of future therapeutic interventions SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and mirna driven conditional attenuation of viral vaccines SAN RAFFAELE MONTE TABOR ORD Infectious Diseases and Microbiology Characterization of post translational modifications of Polycomb Group proteins in differentiation, senescence ad cancer RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. The role of enos in neoplastic progression induced by chronic stress. Development and optimization of a dedicated selfshielded system to perform accelerated partial breast irradiation in prone position after breast conserving surgery. THE GASTRIC SUBMUCOSAL SPACE(GSMS) AS A SITE FOR ISLET ALLOTRANSPLANTATION WITH THE USE OF ALEMTUZUMAB Molecular mechanisms involved in leukocyte recruitment in cerebral vessels and in the pathogenesis of seizures and epilepsy I.E.O. ORD Genes, Genomes and Genetics Emilia Romagna CLI ORD Oncology PASCALE EST Oncology 1 Basic REGINA ELENA CLI COF Oncology Sicilia EST Endocrinology, Metabolism, Nutrition and Reproductive NEUROLESI ORD Brain Disorders and Pagina 81 di 332

82 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Prospective multicenter study on the efficacy of a new, taylored on risk class, antibiotic prophylaxis protocol in preventing neurosurgical Surgical Site Infection (SSIs). Human Cytomegalovirus (HCMV) specific T cell immunity monitoring and inflammatory response analysis in solid organ transplant recipients: from pathogenesis to clinical application Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 10, Lombardia CLI ORD Infectious Diseases 10, and Microbiology Toscana CLI ORD Infectious Diseases 10, and Microbiology SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche ORD Brain Disorders and 10, Studying the tumour microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma: the role of Mesenchymal stem cells Allergy management based on the neonatal risk: a technological pathway. Prevalence of Neonatal Adverse Outcomes and Their Risk Factors and Study on Adverse Medication Effects on the Newborn Health. Neurophysiological and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinson s Disease with Dementia C.R.O. AVIANO ORD Oncology 1 Basic 10, SAN MATTEO ORD Risk, Prevention 10, and Health Behavior Veneto CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 10, NEUROLESI EST Brain Disorders and 10, Pagina 82 di 332

83 Assessing antibiotic resistance in nonpathogenic food related bacteria: the impact on human gut microbiota Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 10, (5) Campylobacter, L. monocytogenes and Verocytotoxin producing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary 10, (5) Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy and give new insight into monogenic type 2 diabetes. OSPEDALE BAMBINO GESU' ORD Digestive, Kidney 10, and Urological Systems The effect of pulmonary rehabilitation on the reduction of acute exacerbations in patients with COPD. The impact of inflammatory phenotype Proposal for a multidisciplinary integrated approach to the health management of myotonic dystrophy type 1 (DM1) New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Docetaxel, Cisplatin and 5 Fluorouracil followed by concomitant Radiotherapy and PF in Locally advanced Head and Neck carcinoma: A phase II study proposal A new approach to study the genetic basis of sporadic non syndromic mental retardation with next generation technologies DON GNOCCHI CLI ORD Cardiovascular and 10, Respiratory SAN RAFFAELE PISANA CLI ORD Healthcare Delivery 10, and Methodologies Puglia ORD Surgical, Biomedical Imaging, and Bioengineering 10, Lombardia CLI COF Oncology 2 10, (1) BURLO GAROFALO ORD Genes, Genomes 10, and Genetics Pagina 83 di 332

84 PRIMARY CILIUM, NPC1 AND PATCHED1 PROTEINS, AND CERAMIDE IN NIEMANN PICK TYPE C DISEASE Toscana ORD Brain Disorders and 10, ECHOCARDIOGRAPHIC EPICARDIAL FAT THICKNESS AS NEW PREDICTIVE MARKER OF CARDIOVASCULAR EVENTS AND CARDIAC REMODELLING Driving Neuronal Recycling in Developmental Dyslexia. Toward a Neuro Psycho Educational approach to differentiate rehabilitation strategies according to different neuro functional profiles of dyslexic children. Whole exome approach to identify the gene responsible for a novel condition associating severe mental retardation with skeletal dysplasia (SEMD Mental Retardation) SAN DONATO CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 10, STELLA MARIS CLI ORD Brain Disorders and 10, ARCISPEDALE EST Genes, Genomes 10, and Genetics IN VITRO GENERATION OF HEMOGENIC ENDOTHELIUM FROM HUMAN CORD BLOOD: A NEW TOOL FOR STUDYING THE DEVELOPMENT OF THE HEMATOPOIETIC SYSTEM AND FOR REGENERATIVE MEDICINE Istituto Superiore di Sanita' ORD Cell Biology 10, Structural analysis of nucleophosmin as a target for acute myeloid leukemia treatment Prognostic role of serum pro PSA, circulating tumor cells and serum testosterone levels in prostate cancer patients with biochemical progression undergoing androgen deprivation therapy Abruzzo ORD Biological Chemistry and Macromolecular Biophysics 10, Piemonte CLI ORD Oncology 2 10, Pagina 84 di 332

85 Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia SAN RAFFAELE MONTE TABOR ORD Immunology 10, Role of the intermediate conductance Caactivated K channels in glioblastoma induced angiogenesis THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS Umbria ORD Oncology 1 Basic 10, MONDINO ORD Molecular, Cellular, 10, and Developmental Validation of a prognostic multigene classifier for larynx carcinoma, application to fine needle biopsies and functional analyses of classifier genes IRCCS AOU San Martino IST (Genova) CLI ORD Oncology 2 10, Real time fmri based motor imagery in chronic post stroke patients: randomized clinical trial of efficacy. Juvenile osteoporosis in patients with autoimmune thyroiditis: an observational study IMPLEMENTATION AND TESTING OF AN E HEALTH BASED SYSTEM FOR EARLY DIAGNOSIS AND INTERVENTION ON SPECIFIC READING DISORDERS STELLA MARIS CLI ORD Emerging Technologies and Training in s 10, Emilia Romagna CLI ORD Musculoskeletal, 10, Oral and Skin MEDEA CLI ORD Healthcare Delivery 10, and Methodologies Telemonitoring in Heart Failure Liguria CLI ORD Bioengineering 10, and Technologies Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedule in patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna CLI ORD Oncology 2 10, Pagina 85 di 332

86 Bilateral sequential lung and pancreas transplantation and combined en bloc liverpancreas transplantation in patients with cystic fibrosis DOSE WARPING METHODS FOR IGRT AND ADAPTIVE RT: DOSE ACCUMULATION BASED ON ORGAN MOTION AND ANATOMICAL VARIATIONS OF THE PATIENTS DURING RADIATION THERAPY TREATMENTS Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10, Emilia Romagna COF Oncology 2 10, Molecular determination of Salmonella serovars by using microsphere based suspension array Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 10, (5) Patient specific Induced Pluripotent Stem Cells (ipscs) to model neurodegeneration and to test gene therapy approaches in Lysosomal Storage Disorders (LSDs). SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 10, and Genetics Observational research: Psychological follow up in living donation process. AN INNERVATED TISSUE ENGINEERING APPROACH TO RECONSTRUCT THE ESOPHAGUS An open source computer package for estimating the burden of cancer disease using a Bayesian back calculation approach. The adenosine receptors: potential targets for diagnosis, prognosis and therapy of cancer A population genetics approach to identify novel susceptibility alleles for chronic inflammatory conditions: application to multiple sclerosis and inflammatory bowel disease Veneto CLI ORD Risk, Prevention 10, and Health Behavior Veneto ORD Surgical, Biomedical Imaging, and Bioengineering 10, Toscana ORD Healthcare Delivery 10, and Methodologies Emilia Romagna ORD Oncology 2 10, MEDEA ORD Genes, Genomes 10, and Genetics Pagina 86 di 332

87 Dermatological complications from metals and metal oxide nanoparticles (MONp) contained in tattoos: a population based study EXOME RESEQUENCING IN UNEXPLAINED RARE BLEEDING DISORDERS Istituto Superiore di Sanita' ORD Healthcare Delivery and Methodologies 10, MAGGIORE ORD Genes, Genomes 10, and Genetics Macrophage polarization and HIV infection. A model of multiple restrictions of the virus life cycle. SAN RAFFAELE MONTE TABOR ORD AIDS and Related 10, Research ß amyloid control of peripheral and neuronal glucose uptake DOPAMINERGIC MODULATION OF TONIC GABAA INHBITION: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS FOR ABSENCE SEIZURES NEUROMED COF Brain Disorders and 10, NEUROMED EST Brain Disorders and 10, "In vivo" characterization of anti podocyte antibodies in auto immune glomerulonephritis. Pathogenetic implication and validation as clinical bio markers GASLINI ORD Digestive, Kidney 10, and Urological Systems A study on the economic and social burden of Parkinson s Disease in Italy and a cost benefit analysis of disease modifying therapies. Italian Network for congenital myasthenic syndromes: from diagnosis to functional in vivo and in vitro studies for clinical applications Simultaneous inhibition of PARP and homologous recombination: a new hypothesis for radiosensitization SAN RAFFAELE PISANA CLI ORD Healthcare Delivery 10, and Methodologies CARLO BESTA ORD Musculoskeletal, 10, Oral and Skin ONCOLOGICO DI BARI ORD Oncology 2 10, Pagina 87 di 332

88 NEW MOLECULES AS DISEASE MODIFYING DRUGS FOR OSTEOARTHRITIS TREATMENT Acid sphingomyelinase in melanoma development and progression Comparative analysis of the leukemia associated fusion proteins TEL/AML1 and AML1/ETO. Istituto Superiore di Sanita' ORD Musculoskeletal, 10, Oral and Skin Lombardia ORD Oncology 1 Basic 10, I.E.O. ORD Vascular and 10, Hematology An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 10, (5) Insight into molecular events involved in the cooperation between bcl 2/bcl xl and hypoxia in the regulation of tumor progression and angiogenesis GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS AS A DRUGGABLE TARGET TO DEVELOP A PHARMACOLOGICAL STRATEGY IN ALEXANDER DISEASE REGINA ELENA ORD Oncology 1 Basic 10, GASLINI ORD Genes, Genomes 10, and Genetics Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 10, and Microbiology Environmental factors and epigenomics in primary biliary cirrhosis HUMANITAS ORD Genes, Genomes 10, and Genetics ADAM17/TIMP3 axis modulates immune cell activation in a model of neurovascular dysfunction SANTA LUCIA ORD Brain Disorders and 10, Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO ORD Oncology 2 10, Pagina 88 di 332

89 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR SENTINELS FOR INFECTIOUS DISEASES? Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 10, Fast tracking of proximal femur fractures: evaluation of the efficacy by means of quantitative neuromotor conditions assessment at mid time follow up. Long term safety and efficacy of thalidomide in IBD. Validation of an event based progression model of Alzheimer disease incorporating quantitative MRI information Combination of carfilzomib and pomalidomide, two last generation proteasome inhibitor and immunomodulating agents, for the treatment of patients with multiple myeloma relapsed after or refractory to lenalidomide: an international (EMNTG) phase I II clin Innovative therapeutic strategies to prevent microvascular injury, multiple organ failure and mortality in sepsis through inactivation of circulating plasma exosomes: the SEPTOSOMES theory ROLE OF RESIDENT ADULT RENAL PROGENITOR/STEM CELLS IN THE REPAIR OF ACUTE KIDNEY INJURY. A HIGH THROUGHPUT APPROACH BY OMICS AND SYSTEMS LOGY RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10, BURLO GAROFALO CLI EST Digestive, Kidney 10, and Urological Systems SANTA LUCIA CLI ORD Brain Disorders and 10, CROB ORD Oncology 2 10, Piemonte ORD Immunology 10, Puglia ORD Digestive, Kidney 10, and Urological Systems Pagina 89 di 332

90 Molecular and metabolic signature of Gleason grading in prostate cancer Study on the Mammalian Target of Rapamycin (mtor) signaling pathway as a potential antiepileptogenic therapy Emilia Romagna EST Oncology 1 Basic 10, Calabria ORD Brain Disorders and 10, Treatment of Neurological Impairment in Lysosomal StorageDiseases by the Use of Neural Stem Cells CASA SOLLIEVO SOFFERENZA ORD Molecular, Cellular, 10, and Developmental Pathogenesis of bone alterations in chronic liver diseases: study and identification of cellular and molecular mechanisms. Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study. AUXOLOGICO ORD Musculoskeletal, 10, Oral and Skin ARCISPEDALE CLI ORD Healthcare Delivery 10, and Methodologies Development of an exosome based in vivo test to detect prions in blood Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Molecular, Cellular, 10, and Developmental Pathogenetic role and potential clinical exploitation of the CCL2/CCR2 axis in the regulation of immune responses in ALS Chromosomal instability (CIN) and evaluation of new biomarkers for early diagnosis of oral squamous cell carcinoma Striatal synaptic plasticity in experimental models of Parkinson's disease with different degrees of dopamine denervation: molecular mechanisms and therapeutics implications HUMANITAS ORD Immunology 10, Piemonte CLI ORD Oncology 2 10, SANTA LUCIA ORD Brain Disorders and 10, Pagina 90 di 332

91 TELE PHYSICO TELEMEDICINE FOR PHYSICAL HEALTH PROMOTION IN TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre randomised controlled trial. FATEBENEFRATELLI CLI ORD Risk, Prevention 10, and Health Behavior Building a Diffusion Tensor Magnetic Resonance Imaging Risk Score to characterize motoneuron disease phenotypes and to discriminate high progressive from low progressive patients with Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Progressiv CASA SOLLIEVO SOFFERENZA ORD Bioengineering 10, and Technologies Expression of estrogen receptors and neuroglobin as a new tool to assess stratification of Parkinson's disease patients Modulation of HIF by new synthetic PHD2 inhibitors for a new and effective treatment of ischemic heart failure Study of the P2RX7 gene coding the purinergic P2X7 receptor for extracellular ATP, as a susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms identified in a cohort of ALS patients. PRE CLINICAL EVALUATIONS OF CELL THERAPY FOR OSTEOARTHRITIS TREATMENT Driver mutations and initiating cells in leukaemia: identification of new druggable targets Piemonte ORD Brain Disorders and 10, SAN DONATO EST Cardiovascular and 10, Respiratory SANTA LUCIA ORD Brain Disorders and 10, RIZZOLI EST Musculoskeletal, 10, Oral and Skin I.E.O. ORD Oncology 1 Basic 10, Pagina 91 di 332

92 Combining exome sequencing and induced pluripotent stem cells for the identification of novel pathogenetic mechanisms and therapies in human cardiomyopaties MULTIMEDICA ORD Cardiovascular and 10, Respiratory IL 21 mediated dysregulation of FoxP3 promotes resistance to tolerance in transplantation SAN RAFFAELE MONTE TABOR ORD Immunology 10, D DIGE based proteomic study for biomarkers discovery in HNPCC patients Localizing the epileptogenic zone in presurgical evaluation of drug resistant focal epilepsies: a complex network based approach A cooperative translational study focused on inflammation and eicosanoids to identify mechanism and predictors of preeclampsia ObeSity And renal Function in pediatric age: an epidemiological study in the CAlabrian region investigating Renal dysfunction in overweight/obese adolescents The SAFEGUARD CKD project. Functionalized polymeric hydrogels and autologous stem cells characterisation as scaffold for tissue regeneration PASCALE ORD Oncology 2 10, CARLO BESTA ORD Surgical, Biomedical Imaging, and Bioengineering 10, Veneto ORD Endocrinology, Metabolism, Nutrition and Reproductive 10, Calabria CLI ORD Population 10, and Epidemiology MULTIMEDICA ORD Bioengineering 10, and Technologies Prof of Concept combination strategy for HIV prevention and control: does microbicide during vaccination impact on B cell immune responses? SAN RAFFAELE MONTE TABOR ORD AIDS and Related 10, Research Governance of diabetes management in nonspecialistic hospital settings. Emilia Romagna CLI ORD Healthcare Delivery 10, and Methodologies Pagina 92 di 332

93 System biology approach to define etiology and pathogenesis of idiopathic non histaminergic angioedema with normal C1 inhibitor Chronic kidney disease and cardiovascular risk in Italy. A population based longitudinal study exploiting the CNESPS ISS biological specimen bank Lombardia ORD Genes, Genomes and Genetics 10, Istituto Superiore di Sanita' ORD Population 10, and Epidemiology Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress OSPEDALE BAMBINO GESU' ORD Vascular and 10, Hematology Study of the role of epigenetics in the regulation of microrna expression in heart failure to identify novel therapeutic targets HUMANITAS EST Cardiovascular and 10, Respiratory ROLE OF TGFbeta AND HER 2 PATHWAYS IN THE DEVELOPMENT OF EMT, ENDOCRINE RESISTANCE AND BREAST CANCER PROGRESSION Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis. Sicilia EST Oncology 2 10, Emilia Romagna ORD Infectious Diseases 10, and Microbiology In vitro and in vivo effects of post transplant cyclophosphamide as novel immunosuppressive regimen for hematopoietic stem cell transplantation from partially HLA matched donors IRCCS AOU San Martino IST (Genova) ORD Immunology 10, Neurobiological, pharmacological and clinical studies on Attention Deficit Hyperactivity Disorder (ADHD): from patients to animal models and back. STELLA MARIS ORD Brain Disorders and 10, Pagina 93 di 332

94 Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections. Istituto Superiore di Sanita' ORD Bioengineering 10, and Technologies Validation in genetic mouse models and in human cells of two gene therapy approaches against striatal degeneration and Huntington's Disease SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 10, PRECLINICAL DEVELOPMENT OF NOVEL SMALL ANDROGEN RECEPTOR MODULATING MOLECULES (SARMS) IN EXPERIMENTAL HUMAN PROSTATE CANCER MODELS Defining and defeating the negative effects of aging and heart failure on stem cell therapeutic potential alpha7 nachr status and response to donepezil in AD patients GENOTYPE AND ENVIRONMENT INFLUENCES ON THE TUMOR PROLIFERATION DYNAMICS INFERRED WITH NEXT GENERATION SEQUENCING Role of Innate Immunity, Inflammasome and RAAS in the progression of type 2 diabetes through the regulation of hepatic, cardiovascular and endothelial function Assessing human minor histocompatibility antigen (mha) and human Cytomegalovirus (CMV) specific T cell responses as prognostic marker for infection and chronic allograft rejection. Emilia Romagna ORD Oncology 2 10, Friuli Venezia Giulia ORD Cardiovascular and 10, Respiratory SAN RAFFAELE PISANA CLI ORD Brain Disorders and 10, I.E.O. ORD Oncology 1 Basic 10, Lazio ORD Endocrinology, Metabolism, Nutrition and Reproductive 10, Veneto CLI ORD Infectious Diseases 10, and Microbiology Pagina 94 di 332

95 FREMS for Acute Inflammatory Bowel Disease: a Phase I/II trial Lazio CLI COF Digestive, Kidney 10, and Urological Systems BRAIN [18F]FDG PET NORMATIVE DATABASE Toscana CLI ORD Brain Disorders and 10, Serine racemase: an emerging therapeutic target for the treatment of schizophrenia and neurodegenerative diseases. EVALUATION OF THE ROLE OF HPV INDUCED IMMUNE RESPONSE IN VACCINE RELATED EFFICACY: COMPARISON BETWEEN BIVALENT AND QUADRIVALENT HPV VACCINES IN FEMALES AND MALES MAUGERI ORD Biological Chemistry and Macromolecular Biophysics 10, MAGGIORE ORD Risk, Prevention 10, and Health Behavior Staphylococcal enterotoxin in traditional raw ewe milk Pecorino cheese: risk assessment and proteomic characterization Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 10, EXPERIMENTAL EVIDENCES ON POSSIBLE TOXIC EFFECTS OF LEVODOPA ON MAMMALIAN SUBSTANTIA NIGRA DOPAMINERGIC NEURONS A toxicological redox assay as a new tool for the discovery of susceptibility biomarkers in Parkinson s disease SANTA LUCIA ORD Brain Disorders and 10, MONDINO EST Brain Disorders and 10, Experimental intra tonsillar prion infection in sheep: a pathogenetic insight into classical and atypical scrapie propagation. Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary Common pathogenic pathways in Motor Neuron Diseases : a study on the relation between SMN and TLS/FUS SANTA LUCIA ORD Molecular, Cellular, and Developmental Pagina 95 di 332

96 Genetic polymorphisms and noninvasive scores for screening patients with progressive nonalcoholic fatty liver disease (NAFLD): an international multicenter collaborative study Early integration of palliative care with standard oncologic care in advanced non small cell lung cancer. A prospective, multi center observational study to evaluate how this approach impact on patient s survival and quality of life with an additional ana HBV related chronic hepatitis: bone metabolism study in naïve patients and in long term therapy with nucleos(t)ide analogue Efficacy of chronomodulated opioid administration in the prevention of breakthrough cancer pain: a phase III randomized multicentre trial Hydrocarbons and kidney damage: potential use of Neutrophil Gelatinase associated Lypocalin and Sister Chromatide Exchange Piemonte ORD Digestive, Kidney and Urological Systems I. O. V. CLI ORD Healthcare Delivery and Methodologies Piemonte CLI ORD Digestive, Kidney and Urological Systems Piemonte CLI ORD Oncology Istituto Superiore di Sanita' CLI ORD Digestive, Kidney and Urological Systems Evaluation of Opisthorchis felineus metacercariae infectivity after fish fillets freezing at different time temperature combinations. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary Biological nurturing and exclusive breastfeeding at 12 weeks: a randomised controlled trial Estimation of cured patients among persons living with neoplasms BURLO GAROFALO CLI ORD Healthcare Delivery and Methodologies C.R.O. AVIANO ORD Population and Epidemiology Pagina 96 di 332

97 IDENTIFYING CORRELATIONS BETWEEN GENOTYPES AND PHENOTYPES OF DENT'S DISEASE. PARTICIPATION TO THE INTERNATIONAL DENT S DISEASE REGISTRY Veneto ORD Digestive, Kidney and Urological Systems Inflammasome deregulation in the macrophage lineage in the pathogenesis of CRMO OSPEDALE BAMBINO GESU' ORD Musculoskeletal, Oral and Skin ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES Dissecting microrna function in mesothelioma development and progression Role of Echocardiogram combined with biomarkers and mirna in early detection of myocardial injury do to anthracyclines and trastuzumab. CROB ORD Vascular and Hematology PASCALE ORD Oncology 1 Basic Emilia Romagna ORD Cardiovascular and Respiratory Correlation between HIV Associated Neurocognitive Disorders (HAND) and HIV and Cytomegalovirus (CMV) specific immune activation and inflammation in peripheral blood and central nervous system (CNS) in HIV infected antiretroviral naive patients Lombardia CLI ORD AIDS and Related Research PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) AMONG ITALIAN REGIONS Lazio CLI ORD Risk, Prevention and Health Behavior Pagina 97 di 332

98 Nanoparticle delivered gene therapy to overcome remyelination failure resulting from blocked mature oligodendrocytes in multiple sclerosis like disease Targeting Th17 in cystic fibrosis as a pharmacological strategy and immunogenetic screening A novel approach for fusion transcript identification and its application to primary malignant bone tumours. Study of basic and clinical aspects of mitotane treatment in patients with adrenocortical carcinoma. CARLO BESTA ORD Brain Disorders and Umbria ORD Infectious Diseases and Microbiology Toscana ORD Genes, Genomes and Genetics Piemonte ORD Oncology LOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary ABCB1/P glycoprotein expression: a biological stratification of the risk in patients with non metastatic osteosarcoma of the extremity. An Italian Sarcoma Group prospective study (ISG/OS 2). Emilia Romagna CLI ORD Oncology Efficacy of a neuromotor and cognitive behavioural training for disability, kinesiophobia and gait disturbances in chronic non specific low back pain An Italian multidisciplinary clinic for Wolfram Syndrome MAUGERI CLI ORD Musculoskeletal, Oral and Skin GASLINI CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 98 di 332

99 gene environment and gene gene association analyses on cognitive phenotypes in Italian nuclear families of dyslexia A novel in vivo diagnostic test for Creutzfeldt Jakob disease (CJD) patients by nasal brushing Modeling Leigh Syndrome with induced pluripotent stem cells: novel tools to investigate energetic neuronal metabolism. The role of the cerebellum in emotion recognition processes: cerebellar TMS as a rehabilitative treatment for schizophrenic patients. Glioblastoma multiforme long survivors: impact of molecular profile on prognosis MEDEA ORD Brain Disorders and Istituto Superiore di Sanita' EST Brain Disorders and MAGGIORE ORD Brain Disorders and SANTA LUCIA CLI ORD Brain Disorders and Toscana ORD Oncology Does timing of VT ablation affect prognosis in patients with an implantable cardioverterdefibrillator? SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and Respiratory Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration : role of genome instability associated with tau mutations Diagnostic impact of circulating mirna and cancer cells in poorly differentiated carcinomas of the lung and breast. CARLO BESTA ORD Brain Disorders and Emilia Romagna ORD Oncology TDP43 translocation in response to synaptic SANTA LUCIA ORD Molecular, Cellular, activation: a study on wild type and mutant forms. and Developmental Pagina 99 di 332

100 Pancreatic non endocrine fraction conversion into insulin producing tissue by acting on TLRs: a potential pathway to improve the transplantable beta cell mass for T1DM therapy SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive Molecular genetic variants and circulating levels of natriuretic peptides: assessment of their predictive role for cardiovascular acute events and cardiovascular diseases in a general Italian population NEUROMED CLI EST Cardiovascular and Respiratory New insigths in the treatment of necrotizing enterocolitis: Modulation of the cholinergic antiinflammatory Sicilia EST Surgical, Biomedical pathway with the use of Imaging, and Bioengineering melanocortins in an experimental neonatal model INVESTIGATING PROGRESSION FROM SAN RAFFAELE MONTE PRENEOPLASTIC TO NEOPLASTIC DISEASE IN TABOR ESOPHAGEAL AND PANCREATIC CANCER BY MEANS OF AN INTEGRATIVE GENOMICS NEXT GENERATION SEQUENCING BASED APPROACH. CLI ORD Digestive, Kidney and Urological Systems Alliance for secondary cardiovascular prevention in the Emilia Romagna region: a randomised clinical trial comparing an intensive, nurse led structured programme with usual care Group I metabotropic glutamate receptors and regulation of synaptic plasticity in a mouse model of Angelman syndrome Emilia Romagna CLI ORD Cardiovascular and Respiratory NEUROMED EST Brain Disorders and Exploiting the p53 p66shc signalling pathway to identify new molecular markers for the prevention of cancer and age related diseases I.E.O. ORD Biology of Development and Aging The role of mirna in MYC regulatory network Toscana ORD Oncology 1 Basic Pagina 100 di 332

101 Interplay between cancer senescent cells and immune system: implications for treatment of breast cancer MAUGERI ORD Oncology 1 Basic Toremifene in desmoid tumors: safety, efficacy and potential therapeutic targets. ISTITUTO TUMORI MILANO CLI ORD Oncology Structure/function relationships of the long pentraxin PTX3 in the light of its protective role in invasive aspergillosis HUMANITAS ORD Immunology Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary Astrocytic impact to corticostriatal synaptic processing in a mouse model of DYT1 Dystonia Role of the ghrelin gene derived peptides and growth hormone releasing hormone (GHRH) on microrna expression and function in the heart ADVANCED THERAPY IN THE TREATMENT OF SKIN LOSS: HUMAN ALLODERMIS WITH PLATELET GEL AND MINIMALLY MANIPULATED MESENCHIMAL STEM CELLS. SANTA LUCIA ORD Molecular, Cellular, and Developmental Piemonte ORD Cardiovascular and Respiratory Toscana CLI EST Surgical, Biomedical Imaging, and Bioengineering Role of IL 4 producing granulocytes in thymic stromal lymphopoietin dependent Th2 type inflammation in pancreatic cancer SAN RAFFAELE MONTE TABOR ORD Immunology The early phases of diabetic retinopathy: possible role of Pigmented Epithelium Derived Factor in contrasting neuroglial dysfunction Istituto Superiore di Sanita' EST Cell Biology Pagina 101 di 332

102 Functional role of macrophage migration inhibitor factor (MIF) and D dopachrome tautomerase (D DT) in thyroid and colorectal cancer ISTITUTO TUMORI MILANO ORD Oncology 1 Basic Genomic and proteomic profiling in Traumatic Brain Injury patients. Drug drug interactions with antidepressants: identification, impact and prevention in clinical practice Correction of Beta Haemoglobinopathies after in situ gene transfer by homologous recombination GENETIC DETERMINANTS OF LEFT VENTRICULAR HYPERTROPHY Disentangling prenatal and postnatal influences on infant bio behavioral development: a prospective study. Effect of lower limb end effector robot assisted therapy with body weight support vs treadmill gait training in Parkinson Patients. Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Sicilia EST Brain Disorders and NEUROLESI CLI ORD Population and Epidemiology Liguria EST Genes, Genomes and Genetics AUXOLOGICO ORD Cardiovascular and Respiratory MEDEA ORD Biobehavioral and Behavioral Processes SAN RAFFAELE PISANA CLI ORD Brain Disorders and Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease. Istituto Scienze Neurologiche ORD Brain Disorders and Pagina 102 di 332

103 DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO CLI ORD Emerging Technologies and Training in s Immunesurveillance of leukemia by CD1 restricted T cells specific for self lipid antigens SAN RAFFAELE MONTE TABOR ORD Immunology FROM SANGER TO NEXT GENERATION SEQUENCING IN MOLECULAR MEDICINE Quantitative evaluation of the function of the elbow operated through inertial devices PET, serum tumour markers and circulating tumour cells in treatment efficacy assessment for patients with advanced non small cell lung cancer (NSCLC) Whole Exome sequencing a novel modality for diagnostics and disease gene discovery in Cardiomyopathies Gold nanoparticles targeting of beta amyloid plaques in the brain of animal models of Alzheimer's disease Enteric glial cells: at the crossroads of obesity, gastrointestinal neurodysfunction and gut bacterial endotoxins Collaboratory and remote mentoring: a strategy to optimize pancreatic islet isolation. SAN MATTEO CLI ORD Genes, Genomes and Genetics RIZZOLI ORD Musculoskeletal, Oral and Skin Emilia Romagna CLI ORD Oncology MULTIMEDICA CLI ORD Genes, Genomes and Genetics Toscana ORD Brain Disorders and MEDEA EST Digestive, Kidney and Urological Systems Sicilia EST Endocrinology, Metabolism, Nutrition and Reproductive Pagina 103 di 332

104 Circulating micrornas as cancer specific biomarkers Green biofactories and biomolecules for the production of safe, low cost and improved anticancer HPV vaccines. Emilia Romagna ORD Oncology REGINA ELENA ORD Oncology Person/Patient and Family centred care PCC & FCCUnderstanding health care experiences and perceptions of parents of hospitalized premature infants, children with a chronic condition and their parents and health professionals in South Tyrol and other reg Provincia autonoma Bolzano CLI ORD Healthcare Delivery and Methodologies REFINING THE CLINICAL HETEROGENEITY OF AUTISM: WHOLE EXOME SEQUENCING OF MACROCEPHALIC AUTISTIC PATIENTS Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening Deep brain stimulation of the reticular nucleus of the thalamus as a therapy for intractable epilepsy: preliminary investigation. New Amyloid beta oligomeric assemblies in Alzheimer derived samples and their subcellular targeting in living human primary fibroblasts MESOANGIOBLASTS FOR THE CELL THERAPY OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING SKELETAL MUSCLE DIFFERENTIATION OF FSHD MESOANGIOBLASTS IN VITRO AND IN VIVO IN SCID MICE AND IN A MOUSE MODEL OF FSHD. SANTA LUCIA ORD Genes, Genomes and Genetics AUXOLOGICO CLI ORD Healthcare Delivery and Methodologies Toscana ORD Brain Disorders and FATEBENEFRATELLI ORD Brain Disorders and DON GNOCCHI ORD Musculoskeletal, Oral and Skin Pagina 104 di 332

105 Treatment optimization of recurrent glioblastoma Emilia Romagna CLI ORD Oncology Fragile X Protein in breast cancer progression CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic DEVELOPMENT OF MICRORNA BASED ASSAYS FOR DIAGNOSTIC AND THERAPEUTIC INTERVENTION IN STROKE Characterization of anal HPV infection and associated lesions in immunocompetent and immunocompromised hosts. RELATIONSHIP BETWEEN SIRTUIN AND UNCOUPLING PROTEIN GENES AND VASCULAR AGING SDN ORD Brain Disorders and SAN GALLICANO ORD Oncology 1 Basic SAN RAFFAELE PISANA ORD Genes, Genomes and Genetics Sp140 PHD finger as a potential target for chronic lymphocytic leukemia: a multidisciplinary approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics Unveiling the microbial signature of Coeliac Disease MicroRNA as predictive biomarkers in Hepatoblastoma pediatric tumour Predictive markers of the response to acetylcholinesterase inhibitors in Alzheimer s disease Perinatal stress in human and non human offspring: a translational approach to study epigenetic impact on depression. SDN EST Infectious Diseases and Microbiology Istituto Superiore di Sanita' EST Oncology 1 Basic Lombardia ORD Brain Disorders and Istituto Superiore di Sanita' ORD Biobehavioral and Behavioral Processes Pagina 105 di 332

106 Standardized Brain Imaging Database for the Evaluation of Memory Disorders and Cognitive Reserve in Mild Cognitive Impairment and Alzheimer's Disease (SBIDMDCR) SAN RAFFAELE MONTE TABOR ORD Brain Disorders and Development of novel drugs targeting protozoan agents of tropical diseases imported in Italy Exploring the role of Epstein Barr virus infection and innate immune signalling pathways in the pathogenesis of myasthenia gravis Allergens, chemical and biological contaminants in nursery and primary schools: a proposal of a multi method approach for the assessment of the main risk pollutants ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCERCHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology CARLO BESTA EST Brain Disorders and Istituto Superiore di Sanita' ORD Risk, Prevention and Health Behavior Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive Safe eradication of chemoresistant myeloid leukemia with CD44v6 redirected T cells coexpressing a suicide gene SAN RAFFAELE MONTE TABOR ORD Oncology Safety and efficacy of infusion of human adiposederived mesenchymal cells in experimental models of whole and partial liver transplantation in large size animals. DISCHARGE FROM FORENSIC MENTAL HOSPITALS, COMMUNITY TENURE, AND RISK OF RECIDIVISM: A PROSPECTIVE FOLLOW UP STUDY Emilia Romagna ORD Digestive, Kidney and Urological Systems Lombardia CLI ORD Healthcare Delivery and Methodologies Pagina 106 di 332

107 Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO CLI ORD Oncology DISCO TRIP: Disrupting mitochondrial complex I to trigger pseudonormoxia: an anticancer strategy. Emilia Romagna ORD Oncology 1 Basic DEVELOPMENT OF A THYROID CANCER DATABASE TO IMPROVE THE QUALITY OF CLINICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Testing in a whole community the effectiveness of an intensive and comprehensive drug abuse preventive program through wastewater analysis, a novel approach for sensitive and real time estimation of drug consumption Lazio CLI ORD Oncology Lombardia CLI ORD Risk, Prevention and Health Behavior CLINICAL AND GENETIC CHARACTERIZATION OF EARLY COMPLICATIONS IN JUVENILE OBESITY OSPEDALE BAMBINO GESU' CLI EST Endocrinology, Metabolism, Nutrition and Reproductive Novel therapeutic approaches to counteract neuronal loss and cognitive decline in an animal model of AD Hexanucleotide repeat expansion in c9orf72 as a bridge between amyotrophic lateral sclerosis and other neurodegenerative diseases. Abruzzo EST Brain Disorders and AUXOLOGICO EST Brain Disorders and Exploiting the therapeutic and prognostic potential of micrornas in melanoma ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology Pagina 107 di 332

108 GENOMIC VARIATION AND PROTEOMIC PROFILE IN NEONATAL BRONCOPULMONARY DYSPLASIA AND RESPIRATORY DISTRESS CLINICAL SPECTRUM SAN RAFFAELE MONTE TABOR ORD Genes, Genomes and Genetics Control of genome organization by regenerationactivated p38alpha signalling in muscle stem cells Multicenter,Italian,randomized,openlabel,parallel group, non inferiority phase III clinical trial comparing cisplatin 5Fluorouracilcetuximab vs. carboplatin paclitaxel cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck New potential targets for reverting diabetic dysfunction in progenitor cells mobilization and homing SANTA LUCIA ORD Biology of Development and Aging Lombardia CLI ORD Oncology MULTIMEDICA ORD Cardiovascular and Respiratory Investigating fetal programming of complex diseases: role of periconceptional and pregnancy nutrient intake on neonate epigenome and health. SAN RAFFAELE MONTE TABOR ORD Genes, Genomes and Genetics VALIDATION OF NANOPARTICLES FOR DRUG DELIVERY IN HEREDITARY NEUROMUSCULAR DISEASES TREATMENTS OSPEDALE BAMBINO GESU' ORD Molecular, Cellular, and Developmental New therapeutic strategies for the control of fungal infections in the elderly Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology Application of molecular techniques to identify zoonosis agents transmitted by arthropods. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary Low dose effects: in vivo models of chemotherapyradiation therapy interactions Emilia Romagna ORD Oncology Pagina 108 di 332

109 TRAIN: Training through Research Application Italian initiative Istituto Superiore di Sanita' ORD Interdisciplinary Molecular and Training Chimeric antigen receptor redirected T cells targeting CD19 for therapy of high risk/relapsed childhood acute lymphoblastic leukemia OSPEDALE BAMBINO GESU' EST Oncology Role of acetylcholinesterase R in the treatment of Myastenia Gravis. SAN RAFFAELE PISANA CLI ORD Oncology Genetics of cardiovascular disease in patients with type 2 diabetes. An integrated approach, including epidemiology, gene expression profiles and cell biology functional studies CASA SOLLIEVO SOFFERENZA EST Genes, Genomes and Genetics Multimodal evaluation of stroke patient's mindbrain state during upper limb robot aided therapy Sebum lipidomics: a new tool to correlate skin and systemic lipid metabolism. Integrated approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and long term auxological, neurodevelopmental and metabolic outcomes SAN RAFFAELE PISANA CLI ORD Emerging Technologies and Training in s SAN GALLICANO COF Musculoskeletal, Oral and Skin Piemonte CLI ORD Risk, Prevention and Health Behavior Amantadine treatment for pathological gambling FATEBENEFRATELLI CLI ORD Brain Disorders and Hypothesis driven gene candidate study of copper involvement in the pathogenesis of Alzheimer s disease: detection of sequence changes, haplotype profile of ATP7B gene and their molecular and functional aspects SAN RAFFAELE PISANA CLI ORD Brain Disorders and Pagina 109 di 332

110 New paradigms for Tuberculosis (TB) management using rapid molecular detection of Mycobacterium tuberculosis and Rifampin resistance DO INHIBITORY NETWORKS SUSTAIN SEIZURE GENESIS IN FOCAL EPILEPSY? Emilia Romagna CLI ORD Infectious Diseases and Microbiology CARLO BESTA EST Brain Disorders and 11, Proteomic signatures as biomarkers of breast cancer risk andas predictors of outcome in women with early breast cancer. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 11, SENESCENCE ASSOCIATED micrornas (SAmiRs) IN CELLULAR SENESCENCE AND ORGANISMAL AGING Liposome delivered sirnas inhibition of PTG in Lafora Disease: a model of innovative strategy for treatment of neurometabolic diseases Boosting intratumor tertiary lymphoid structures with IL 7 and LT alpha, to stimulate the immune response against pancreatic cancer. SCREENING OF SOMATIC MUTATIONS IN ADVANCED STAGES LUNG ADENOCARCINOMA THROUGH NEXT GENERATION DNA SEQUENCING Mobile genetic elements: new approaches to molecular epidemiology of antimicrobial resistance genes in Gram negative clinical isolates A Pharmacogenomic Approach to Retinal Neuroprotection in Age Related Macular Degeneration. SDN ORD Biology of 11, Development and Aging GASLINI ORD Genes, Genomes 11, and Genetics HUMANITAS ORD Immunology 11, I.E.O. ORD Oncology 1 Basic 11, Abruzzo ORD Infectious Diseases 11, and Microbiology Lazio CLI ORD Cell Biology 11, Pagina 110 di 332

111 An epigenetic approach to treatment of triple negative breast cancer Identification of chromosomal mosaicisms in amniotic fluid of pregnant women by Pyrosequencing analysis. Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severe Grampositive infections Fertility preservation in women affected by endometriosis through oocyte vitrification Friuli Venezia Giulia ORD Oncology 1 Basic 11, MAGGIORE ORD Genes, Genomes 11, and Genetics Toscana CLI ORD Healthcare Delivery 11, and Methodologies Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, PHASE 2, OPEN LABEL, MULTICENTER, RANDOMIZED STUDY OF PD (ORAL CDK 4/6 INHIBITOR) MONOTHERAPY AND PD IN COMBINATION WITH THE AROMATASE INHIBITOR TO WHICH THE PATIENT HAS PROGRESSED IN THE PREVIOUS LINE FOR ER POSITIVE, HER2 NEGATIVE POST M Toscana CLI ORD Oncology 2 11, PRESERVATION OF THE REPRODUCTIVE FUNCTION IN ONCOLOGICAL CHILDREN AND WOMEN AT RISK OF STERILITY: OVARIAN TISSUE CRYOPRESERVATION IN HYPERBARIC CONDITIONS Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, LOW INVASIVE MARKERS DEVELOPMENT IN COLLAGEN 6 MYOPATHIES AND DUCHENNE MUSCULAR DYSTROPHY FOR DISEASE STAGING AND RESPONSE TO TREATMENT RIZZOLI CLI ORD Musculoskeletal, 11, Oral and Skin Pagina 111 di 332

112 Citicoline treatment for traumatic brain injury NEUROLESI CLI ORD Brain Disorders and 11, Development of a health surveillance system to monitor the impact of rheumatoid arthritis, the quality of care and long term consequences of the disease at the population level Health and equity effects of natural policy experiments in the fields of structural policies and health care organization Acid Retinoic Producing Dendritic Cells as New Therapy for Type 1 Diabetes SAN MATTEO CLI ORD Population 11, and Epidemiology Piemonte CLI ORD Healthcare Delivery 11, and Methodologies Sicilia EST Immunology 11, Targeting patients with recurrent depression and traumas: Comparison of the efficacy of EMDR and of CBT versus standard clinical management, their neurobiological correlates, and the associated health sanitary costs. Piemonte CLI ORD Biobehavioral and 11, Behavioral Processes Perception deficits and visual agnosia in very low birth weight (VLBW) children EFFECTS OF NUTRACEUTICAL SPIRULINA AND DOCOSAHEXAENOIC ACID ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENT AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY STELLA MARIS CLI ORD Brain Disorders and 11, Istituto Superiore di Sanita' ORD Molecular, Cellular, 11, and Developmental In vivo manipulation of gamma delta T cells with zoledronate and low dose IL 2 for immunotherapy of malignant melanoma Sicilia CLI ORD Oncology 2 11, INHIBITION OF GLYCOGEN SYNTHASE KINASE 3 TO IMPROVE THE INTEGRATION OF ENDOSSEOUS IMPLANTS Emilia Romagna ORD Musculoskeletal, 11, Oral and Skin Pagina 112 di 332

113 Individual Susceptibility to Plaque Induced Periodontal Inflammation: Evaluation of Genetic,, Immunological and Microbiological Markers. Management of couples with asymptomatic urogenital infections and ART failure Emilia Romagna ORD Musculoskeletal, 11, Oral and Skin Toscana CLI ORD Infectious Diseases 11, and Microbiology Posttraumatic stress disorder in parents of children with surgically correctable anomalies requiring surgery at birth OSPEDALE BAMBINO GESU' CLI ORD Biobehavioral and 11, Behavioral Processes A new system for integrating monitoring of cardiovascular and neuromuscular activity during free living: set up and clinical validation in patients affected by cardiac arrhythmias and neurological disorders Toscana ORD Cardiovascular and 11, Respiratory value of decompressive craniectomy associated to haematoma evacuation in the first 72 hours after traumatic events: a multicenter randomized controlled trial Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering 11, Caveolin 1, PTRF expression and function in Non Small Cell Lung Cancer. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 11, Diagnosis of estrogen receptor positive breast cancers: innovative markers of risk categories DNA REPAIR SYSTEM AND CISPLATIN RESISTANCE IN OSTEOGENIC BONE TUMOURS: VALIDATION OF MOLECULAR TARGETS AND CLINICAL APPLICATIONS and Molecular aspects of Sunitinib related hyperlipidemia. Piemonte CLI ORD Oncology 1 Basic 11, RIZZOLI ORD Oncology 2 11, Toscana ORD Oncology 2 11, Pagina 113 di 332

114 Proteomics and metabonomics strategies to characterize functional biomarkers of Polycyclic aromatic hydrocarbons contamination on dairy products Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines Development and characterization of a motoneuronal in vitro model of spinal muscular atrophy: a novel platform for the evaluation of candidate compounds to the treatment of the condition Electronic Medical Record for PDD: A powerful tool for health care, clinical governance and epidemiological studies Epigenetic therapy of leukemic stem cells in acute myeloid leukemias. and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Viral respiratory infections in intensive care patients. Role of CREB protein family members in human lymphoid malignancies Nutlin 3 as innovative diagnostic and therapeutic tool for B chronic lymphocytic leukemia Abruzzo ORD Veterinary 11, Toscana ORD Immunology 11, Lazio ORD Molecular, Cellular, 11, and Developmental Istituto Superiore di Sanita' ORD Healthcare Delivery 11, and Methodologies I.E.O. ORD Oncology 1 Basic 11, Toscana CLI ORD Musculoskeletal, 11, Oral and Skin Toscana ORD Infectious Diseases 11, and Microbiology Abruzzo ORD Cell Biology 11, BURLO GAROFALO CLI ORD Oncology 2 11, Pagina 114 di 332

115 BPIFB4 longevity associated variants: evaluation by in vitro and in vivo studies for their potential modulation of diseases of aging Set up and clinical validation of an immunometric assay for the quantification of big gammaglutamyltransferase (b GGT), an emerging biomarker of cardiovascular risk. MITO 7 A Multicenter phase 3 Randomized Study with weekly paclitaxel in patients with Ovarian Cancer treated with first line chemotherapy GENE EXPRESSION PROFILING IN HUMAN ACTH SECRETING PITUITARY TUMORS IN ASSOCIATION WITH CLINICAL AND CHEMICAL FEATURES. Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cells and gamma/delta T lymphocytes and regulation of their cross talk. Novel predictive biomarkers for bevacizumab in colorectal cancer Neurophysiological approach to evaluate cerebrocerebellar interactions. Characterization of a cerebellar connectivity EEG index. Disability related chronic conditions in older adults: an innovative approach to estimate the disease burden and the adherence to evidencebased pharmacological treatments using linked clinical and administrative data. MULTIMEDICA ORD Biology of 11, Development and Aging Toscana ORD Cardiovascular and 11, Respiratory PASCALE CLI ORD Oncology 2 11, AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, Istituto Superiore di Sanita' ORD Immunology 11, I. O. V. ORD Oncology 2 11, SANTA LUCIA CLI ORD Brain Disorders and 11, Lazio CLI EST Healthcare Delivery 11, and Methodologies Pagina 115 di 332

116 Cutaneous sensory and autonomic innervation in early parkinsonism. A new tool to predict clinical evolution toward PD, MSA and PSP. Identification of humoral and cellular biomarkers for cerebro and coronary acute vascular events MAUGERI CLI ORD Brain Disorders and 11, NEUROMED CLI EST Vascular and 11, Hematology Evaluation of the role of Copy Number Variations in the pathogenesis of inherited neurological and neuromuscular disorders through the development and validation of a rapid and efficient laboratory assay IRCCS AOU San Martino IST (Genova) ORD Genes, Genomes 11, and Genetics Autoimmunity in Diabetes: a Holistic Hypothesis of the Diabetes Syndrome Targeting epithelial to mesenchymal transition and chemoresistance mediated by endothelin 1 signaling in epithelial ovarian cancer Reproductive toxicity of Engineered Nanomaterials: mechanisms, effects, biomonitoring and tools for prevention Thyroid hormones, brain tumours and macrophages Early markers of ultrafiltration failure in peritoneal dialysis: a proteomic approach Rehabilitation of somatic deficits after stroke through training and non invasive brain stimulation Genetic basis of steroid resistant nephrotic syndrome and implications for therapy SAN DONATO EST Immunology 11, REGINA ELENA ORD Oncology 1 Basic 11, Lazio ORD Bioengineering 11, and Technologies Lombardia ORD Oncology 1 Basic 11, Puglia ORD Digestive, Kidney 11, and Urological Systems AUXOLOGICO CLI ORD Integrative, Functional, and Cognitive 11, Lombardia ORD Genes, Genomes 11, and Genetics Pagina 116 di 332

117 IDENTIFICATION OF GENES REGULATING SKIN FIBROSIS IN SCLERODERMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 11, Oral and Skin A novel in vivo system for functional reconstitution of bone and a functional bone marrow microenvironment/hematopoietic stem cell niche: a lead into scaffold free, cell only bone regeneration strategies, and into direct modeling of leukemic and cancer st The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? ZnO nanoparticles as selective killers of liver metastasis derived from colon cancer Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies A randomized multi center study for the evaluation of efficacy and safety of two different daily doses of low molecular weight heparin (LMWH) in subjects with cancer and incidentally detected non symptomatic pulmonary embolism Toxins produced by intestinal bacteria and predisposing genetic variations: a dangerous link for colorectal cancer development? Role of Dbl in epithelial cell transformation: identification of new therapeutic targets for carcinomas Lazio ORD Vascular and 11, Hematology Emilia Romagna ORD Brain Disorders and 11, SAN MATTEO ORD Bioengineering 11, and Technologies Sicilia ORD Vascular and 11, Hematology SAN MATTEO CLI ORD Cardiovascular and 11, Respiratory Istituto Superiore di Sanita' EST Oncology 1 Basic 11, Liguria ORD Oncology 1 Basic 11, Pagina 117 di 332

118 Identification of signaling pathway activation profiles in cancer stem cells by mass cytometry, comparison with the reverse phase protein array approach and correlation with sensitivity to pathway targeting drugs. ANALYSIS OF PHERIPHERAL BLOOD DENDRITIC CELLS IN ALZHEIMER S DISEASE Beta adrenergic receptor blockade as a new, effective and safe therapy in the treatment of retinopathy of prematurity Cellular and molecular determinants of mitral valve prolapse Mitochondria involvement in synaptic dysfunction during early stage of Alzheimer's disease Protective role of high density of tumor associated macrophages in stage III colorectal cancer Identification of EphA3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutic approach with a specific monoclonal antibody Does a robot assisted rehabilitation improve brain rhythms and balance in stroke and Parkinson patients? Functional topography of the spinal motor output after spinal cord injury Istituto Superiore di Sanita' ORD Oncology 1 Basic 11, SANTA LUCIA EST Brain Disorders and 11, Toscana ORD Cell Biology 11, MONZINO EST Cardiovascular and 11, Respiratory SANTA LUCIA CLI EST Brain Disorders and 11, HUMANITAS ORD Oncology 2 11, CROB ORD Oncology 1 Basic 11, SAN RAFFAELE PISANA CLI ORD Brain Disorders and 11, SANTA LUCIA ORD Integrative, Functional, and Cognitive 11, Pagina 118 di 332

119 Cotransplantation of pancreatic islets and engineered third party human umbilical cord mesenchymal stem cells. A novel approach to increase graft survival and immune tolerance in type 1 diabetes patients GABAA receptor and chloride transporter physiopathological role in ALS Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, SANTA LUCIA ORD Molecular, Cellular, 11, and Developmental Corticostriatal alterations in dopamine graft transplanted parkinsonian rats: implications for L DOPA therapy SANTA LUCIA EST Brain Disorders and 11, Relevant effect size of GSM electromagnetic fields (EMFs) exposure on neurophysiological and behavioural measures in subjects with mild cognitive Impairment and Alzheimer disease: a qeeg study OASI MARIA S.S. ORD Brain Disorders and 11, High throughput monitoring of pathogen specific cellular immunity as guidance for treatment of opportunistic infections in immunocompromised children. OSPEDALE BAMBINO GESU' CLI ORD Immunology 11, The dietary and genetic protection to coronary artery disease Calabria ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, Development of innovative rapid screening methods of corticosteroids agents in cattle as growth promoters using MEA and an enhanced histopathological approach Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 11, Pagina 119 di 332

120 The treatment adherence in children and adolescents with Spina Bifida and neurogenic bladder: relations with demographic, medical, occupational, cognitive and psycho social variables. Lombardia CLI ORD Healthcare Delivery 11, and Methodologies Disruption of circadian clock and tumorigenesis SANTA LUCIA ORD Genes, Genomes and Genetics 11, Role of PI3K beta in cardiac remodeling and failure Piemonte ORD Cardiovascular and 11, Respiratory Role of adenosine A2A receptors in the pathogenesis of Niemann Pick type C disease: a possible therapeutic target Role of TIR8 in modulating ischemia/reperfusion injury in kidney transplantation Predictive biomarkers of dementia: a longitudinal evaluation of Mild Cognitive Impairment IDENTIFICATION OF MOLECULAR MECHANISMS INVOLVED IN SYNOVIAL OSTEOCHONDROMATOSIS PATHOGENESIS Production and optimization of cartilage and bone spherules for repairing large bone losses and osteoarthritis. Brain Tumor Banking: a tool for research, diagnosis and therapy Early detection of schizophrenia related symptoms in children with 22q11.2 deletion syndrome Istituto Superiore di Sanita' ORD Molecular, Cellular, 11, and Developmental Lombardia ORD Immunology 11, FATEBENEFRATELLI ORD Brain Disorders and 11, Toscana ORD Musculoskeletal, 11, Oral and Skin Istituto Superiore di Sanita' EST Musculoskeletal, 11, Oral and Skin MONDINO ORD Oncology 1 Basic 11, Istituto Superiore di Sanita' ORD Biobehavioral and 11, Behavioral Processes Pagina 120 di 332

121 Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 11, Analysis of development and persistence of protective immunity after new and routine vaccinations in primary and secondary immunodeficiencies OSPEDALE BAMBINO GESU' ORD Immunology 11, Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A preclinical study. Prediction of targeted therapies for hepatocellular carcinoma through molecular profiling of tumorous and cirrhotic tissue DELIVERY OF THERAPEUTICAL AGENTS INTO MELANOMA BY TGF β SWITCH DEPENDENT HOMING OF MESENCHYMAL STEM CELLS (MSC), ENDOTHELIAL PROGENITOR CELLS (EPC) AND ANTIGEN PRESENTING CELLS (APC) Istituto Superiore di Sanita' ORD Oncology 2 11, Emilia Romagna EST Oncology 2 11, Toscana ORD Oncology 1 Basic 11, EVALUATION OF CLINICAL AND EPIDEMIOLOGICAL SIGNIFICANCE OF MYCOBACTERIUM BOVIS AND MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS CELL WALL DEFICIENT FORMS IN ANIMALS, HUMANS AND FOOD SOURCES. Istituto Zooprofilattico Sperimentale della Sardegna ORD Infectious Diseases 11, and Microbiology Reducing the need for intensive care unit in hospitalized patients with early respiratory failure using the non invasive ventilation technique. A multicentre randomized study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 11, Pagina 121 di 332

122 Involvement of Ago1 in neuronal cell fate determination and oncogenesis The added value of amyloid PET with a fluorinated radiotracer in the diagnosis of mild cognitive impairment due to Alzheimer s disease Culture and characterisation of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency Rethinking neuroinflammation in sporadic AD: exploring novel therapeutic and prognostic tools Circuitry rearrangement and clinical outcome of high technological platform based restorative therapy in an ovine model of stroke: definition of microenvironment interactions and epigenetic modification contribution SANTA LUCIA ORD Molecular, Cellular, 11, and Developmental FATEBENEFRATELLI ORD Brain Disorders and 11, Veneto ORD Cell Biology 11, Istituto Superiore di Sanita' ORD Brain Disorders and 11, CARLO BESTA EST Brain Disorders and 11, The use of cell free fetal nucleic acids in maternal plasma for noninvasive prenatal diagnosis of monogenic diseases and screening of fetal aneuploidy SAN RAFFAELE MONTE TABOR CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, Genotoxicity, biochemical and tissutal responses in aquatic organisms exposed to chlorpyrifos and deltamethrin, assessing their risk for animal and human health Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 11, The role of mineralocorticoid receptor (MR) overactivation in obesity:effects of MR blockade in human and animal models of overfeeding. SAN RAFFAELE PISANA EST Endocrinology, Metabolism, Nutrition and Reproductive 11, Pagina 122 di 332

123 Virus associated tumors: identification of novel diagnostic, prognostic and treatment strategies SAN MATTEO CLI ORD Oncology 2 11, Molecular determinants of immune evasion in childhood acute leukemia. OSPEDALE BAMBINO GESU' ORD Immunology 11, PPARgamma receptors as a treatment target for opiate addiction. Combined therapeutic cancer vaccine strategy for HCV related HCC FATEBENEFRATELLI ORD Brain Disorders and 11, PASCALE ORD Oncology 2 11, Telemedicine for monitoring of asthmatic patients Evaluation of the outcome of treatment accordin to the style of life. OSPEDALE BAMBINO GESU' CLI ORD Risk, Prevention 11, and Health Behavior TAT AND ENV BIND TO FORM A NOVEL HIV ENTRY COMPLEX THAT TARGETS CELLS AT THE PORTAL OF ENTRY AND HIV RESERVOIRS: IMPLICATIONS FOR THE DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC INTERVENTIONS AGAINST HIV/AIDS Istituto Superiore di Sanita' ORD AIDS and Related 11, Research Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 11, Mucus Layer Component (Muc2) Contribute to Shape the Intestinal Immune Response Quantitative Advanced Imaging (PET/MRI) in the Surgery and Radiotherapy of High Grade Brain Tumours DE BELLIS ORD Immunology 11, ARCISPEDALE ORD Oncology 2 11, Pagina 123 di 332

124 Genetic and neural mechanism of Major Psychoses: the role of dopaminergic system FATEBENEFRATELLI ORD Brain Disorders and 11, Effect of exposure to environmental and food contaminants, on bone and liver diseases. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 11, TARGETING TRIM32 AS A THERAPEUTIC APPROACH IN NEUROMUSCULAR DISEASES SANTA LUCIA ORD Cell Biology 11, Sharing of medical resources for the diagnosis and treatment of status epilepticus by a computer assisted telemedicine system SAN RAFFAELE MONTE TABOR CLI ORD Emerging Technologies and Training in s 11, Prospective Study on infectious complications in patients receiving biological drugs, either monoclonal antibodies or TNF alpha antagonists. Emilia Romagna CLI ORD Infectious Diseases 11, and Microbiology Mechanism of hypertrophy in genetically determined Hypertrophic Cardiomyopathy (HCM) Lombardia EST Cardiovascular and 11, Respiratory Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 11, Effects of Testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on pump CABG Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11, The role of B cells in Graft versus Host Disease after allogeneic hemopoietic cell transplantation Provincia autonoma Bolzano EST Immunology 11, Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA ORD Biobehavioral and 11, Behavioral Processes Pagina 124 di 332

125 DEVELOPMENT OF A NETWORK BASED MODEL FOR A COMPREHENSIVE CLINICAL DIAGNOSTIC MANAGEMENT OF HEREDITARY CANCER PATIENTS AND THEIR FAMILY MEMBERS Analysis of RNA processing defects in amyotrophic lateral sclerosis Tailoring micro nanocarriers structural and surface properties to finely modulate the activation or regulation of immune responses: the allergy immunotherapy proof of concept Caffeine as a potential therapeutic option for Alzheimer's disease. WHOLE EXOME SEQUENCING OF ADENOMATOUS POLYPOSIS PATIENTS FOR A GENETIC DIAGNOSIS AND CLINICAL APPLICATIONS Porcine St Valerién like caliciviruses: epidemiology, molecular characterization and zoonotic impact I. O. V. CLI ORD Healthcare Delivery 11, and Methodologies SANTA LUCIA ORD Genes, Genomes 11, and Genetics Istituto Superiore di Sanita' ORD Immunology 11, Istituto Superiore di Sanita' ORD Brain Disorders and 11, C.R.O. AVIANO ORD Oncology 1 Basic 11, Abruzzo CLI ORD Veterinary SAFE FISH: safety and nutritional value assessment of Italian marine farmed fish Istituto Zooprofilattico Sperimentale della Sicilia ORD Healthcare Delivery and Methodologies Bacterial adhesion on orthopaedic prosthetic polyethylenes with different chemical and physical properties Piemonte ORD Infectious Diseases and Microbiology Cancer stem cell based markers of disease course and treatment resistance in stage II colon cancer patients Toscana ORD Oncology Pagina 125 di 332

126 Treatment improving of Pompe disease (glycogenosis type II): new insights into chaperone and splicing correcting compounds Toscana CLI ORD Genes, Genomes and Genetics Nutritional factors in Rett syndrome and autism spectrum disorders: preclinical evaluation of dietary choline during early developmental phases Istituto Superiore di Sanita' ORD Brain Disorders and EAAT2 glutamate transporter and oxidative stress studies in amyotrophic lateral sclerosis Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Implementation of cell treatments for untractable immune disorders. Correlation of immunomodulatory potency of BM MSC to the patient's immune activation and development of custom licensing strategies. Sodium channel Nav1.1: the most relevant epilepsy gene. Pathomechanisms and development of novel therapeutic strategies. Global proteomic profiling of mood disorders: search for molecular fingerprints to improve diagnosis, prognosis and guide treatment strategies. Toscana ORD Genes, Genomes and Genetics Emilia Romagna ORD Immunology Toscana CLI ORD Genes, Genomes and Genetics BURLO GAROFALO CLI ORD Immunology Lombardia EST Molecular, Cellular, and Developmental Toscana CLI ORD Brain Disorders and Pagina 126 di 332

127 Telecare and Home Care: assessing costeffectiveness of a new approach to increase safety in home care avoiding the need to hospitalize for elderly, polypathologic, chronically ill, unstable subjects with movement handicaps The reactivity to 35% CO2 challenge as predictor of pharmacological treatment outcome and relapse in Panic Disorder. Development of an in vitro assay for the diagnosis of latent tuberculosis infection (LTBI) based on a novel human immunodominant T cell epitope of the antigen PPE44 of Mycobacterium tuberculosis Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana CLI ORD Healthcare Delivery and Methodologies Lombardia CLI ORD Biobehavioral and Behavioral Processes Toscana ORD Infectious Diseases and Microbiology Toscana ORD Oncology 1 Basic INCIDENCE OF SUBSEQUENT SQUAMOUS CELL CARCINOMA IN NON MELANOMA SKIN CANCER ACCORDING TO SEROPOSITIVITY FOR, AND DNA PRESENCE OF, HPV. ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Oncology 1 Basic Isolation and characterization of interferongamma producing myeloid cells from the bone marrow of Severe Aplastic Anemia patients (SAA) GASLINI ORD Vascular and Hematology Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood Abruzzo ORD Genes, Genomes and Genetics Impact of genetic scores derived from genomewide association studies (GWAS) on the reclassification of cardiovascular risk in the settings of primary and secondary prevention. Veneto ORD Genes, Genomes and Genetics Pagina 127 di 332

128 Validation of a health technology for calculating fractionated doses for pediatric drugs MMP 13: a new therapeutic target in breast cancer bone metastasis Piemonte CLI EST Healthcare Delivery and Methodologies C.R.O. AVIANO ORD Oncology 1 Basic IR A as a new player of sarcoma malignancy RIZZOLI ORD Oncology 1 Basic Flexible endoscope used in laparoscopic surgery: analysis of possible applications A Phase II Randomized Multicentre Study of SystemicChemotherapy versus Systemic Chemotherapy plus SIR Spheres as SecondLine in KRAS Mutant Unresectable Colorectal Liver Metastases (SITILO 2) mir34a: clarifying its value in prognosis and therapy of Ewing s sarcoma. Motor underpinnings to screen autism (MUSA). Prospective study on movement perception and performance in younger siblings of children with Autism Spectrum Disorders. Searching for clinical predictors and neural correlates of early autism. Veneto ORD Surgical, Biomedical Imaging, and Bioengineering Lazio CLI COF Oncology RIZZOLI ORD Oncology 1 Basic STELLA MARIS CLI ORD Brain Disorders and Tissue penetrating peptides coated nanoparticles as a personalized strategy for the targeted delivery of anticancer agents to solid tumors Liguria ORD Oncology NF kb signaling pathway,innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI ORD Brain Disorders and Pagina 128 di 332

129 Pathogenetic role of B cell activating factor and novel markers of lymphoma onset in Sjögren's syndrome HUMANITAS ORD Immunology Microbiological hazards in ready to eat fruit commodities Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary Use of a new material (polipropilene biofilm) with coated nanoparticles for the release of antibacterial drugs instead of surgical mesh for the reconstructive surgery of pelvic floor. Sentinel animals to monitor pollution around the former Balangero asbestos mine Lazio COF Digestive, Kidney and Urological Systems Piemonte ORD Population and Epidemiology Gene expression profile at the onset of severe cardiac failure:identification and validation of new biomarkers Liguria ORD Cardiovascular and Respiratory ENHANCING ISLET TRANSPLANT SUCCESFULL BY DE NOVO TISSUE EXPRESSION OF TRUNCATED ERYTHROPOIETIN RECEPTOR. SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive NEW DRUGS FOR BONE MASS RECOVER IN OSTEOPOROTIC PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS (RA): CLINICAL/MEDICAL STUDY. Emilia Romagna ORD Musculoskeletal, Oral and Skin High Obesity risk in Children and Adults with Narcolepsy Cataplexy Istituto Scienze Neurologiche ORD Risk, Prevention and Health Behavior Characterization of the role of HIV1 Tat in establishment and maintenance of viral reservoirs: implications for new strategies toward HIV eradication Emilia Romagna ORD AIDS and Related Research Pagina 129 di 332

130 Study of the molecular profile of circulating tumor cells for outcome prediction to docetaxel in metastatic castration resistant prostate cancer patients A phase III study (IRMA3): breast cancer at low risk of local recurrence: irradiation and accelerated partial three dimensional conformal radiotherapy (3D CRT) versus standard radiotherapy and intraoperative radiotherapy(iort) versus standard radiotherapy A comprehensive immunological strategy for the prevention of relapse in elderly patients with acute myeloid leukemia according to genotype: adoptive immunotherapy with NK cells and anti WT1 vaccination Studies on the functional role and regulation of a restricted signature of micrornas in acute myeloid leukemia Myocardial regeneration and functional recovery of the infarcted heart:role of pericardial fluids IDENTIFICATION OF MARKERS AND DEVELOPMENT OF SENSORS FOR EARLY PANCREATIC CANCER DIAGNOSIS Biological characterization of onset in Bipolar Disorder: a fmri study with BDNF polymorphisms and methylation patterns analysis in patients before and after first pharmacological treatment Diagnosis and pathogenesis of Opisthorchis felineus, an emerging foodborne parasite in Italy Emilia Romagna ORD Oncology Emilia Romagna CLI ORD Oncology Emilia Romagna CLI ORD Oncology REGINA ELENA EST Oncology 1 Basic SAN RAFFAELE PISANA EST Cardiovascular and Respiratory Piemonte ORD Bioengineering and Technologies MAGGIORE ORD Biobehavioral and Behavioral Processes Istituto Superiore di Sanita' ORD Infectious Diseases and Microbiology Pagina 130 di 332

131 THE ROLE OF MELANOPSIN RETINAL GANGLION CELLS IN PHOTOENTRAINMENT OF CIRCADIAN RHYTHMS IN NEURODEGENERATION AND AGING Istituto Scienze Neurologiche ORD Brain Disorders and A prospective study on Oxaliplatin neurotoxicity: from basic science to rehabilitation looking for early preclinical signs of neuropathy. Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Dissecting the molecular regulatory networks in human myeloid derived suppressor cells. PanCareSurFupPanCare Childhood and Adolescent Cancer Survivor Care and Follow up Studies, Italian branch Controlled Ex Vivo Expansion of Human Mesenchymal Stem Cells Methodologies: A First Step Toward ly Relevant Bone Regeneration S.CAMILLO CLI ORD Oncology Toscana ORD Brain Disorders and I. O. V. ORD Immunology Piemonte ORD Oncology RIZZOLI EST Cell Biology A new approach to cancer early diagnosis based on the identification of breast cancer related metabolites in human breath ISTITUTO TUMORI MILANO ORD Oncology Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI ORD Bioengineering and Technologies Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia CLI ORD Infectious Diseases and Microbiology Pagina 131 di 332

132 Tackling the immune system to drive muscle neoangiogenesis and regeneration: a possible tool to limit age related muscle wasting SAN RAFFAELE MONTE TABOR ORD Biology of Development and Aging Development of a novel test for detection of Bacillus anthracis DNA in urine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Infectious Diseases and Microbiology Anti thrombogenic and antimicrobial intravascular catheters for patients hospitalized in clinical settings for neuromotor rehabilitation and long term care SANTA LUCIA CLI ORD Infectious Diseases and Microbiology Fluidodynamics of Fontan operation: A data base aiming at improvement of surgical outcome of the univentricular heart OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and Respiratory Development of novel gene therapy approaches to cure the primary ciliary dyskinesia Identification of common pathways that drive the metastatic disease through mirna profiling of transgenic mouse models and human cancers CHARGE SYNDROME: UNRAVELLING THE MOLECULAR BASES WITH TRADITIONAL AND INNOVATIVE APPROACHES G15 expression in pancreatic cancer:its prognostic and diagnostic value as a clinical/molecular marker and as a pharmacological target Potential role of TRPM8/TRPV2 channels in breast and prostate cancers: expression, biophysics and pharmacology Toscana ORD Cardiovascular and Respiratory MAGGIORE ORD Oncology 1 Basic Emilia Romagna ORD Genes, Genomes and Genetics Veneto ORD Oncology 1 Basic ONCOLOGICO DI BARI ORD Oncology 1 Basic Pagina 132 di 332

133 HIV drug resistance in resource limited settings : an assessment in naïve pregnant women in Malawi and the evaluation of the impact of a triple antiretroviral combination strategy for PMTCT Istituto Superiore di Sanita' ORD AIDS and Related Research Identification of immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease Evaluation of new glucocorticoids and innovative combination therapy in the management of spinal cord injury Associations between ambulatory blood pressure monitoring profiles, cognitive decline, and diastolic dysfunction in the very elderly population: a multicentre study to identify novel, population specific, management algorithms. Telomere Length, Risk of Ischemic Stroke and Prediction of Poststroke Recurrent Events Hypoxia, inflammation and stem cells in cancer progression Identification of downstream targets of BAG3/BRAF mediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma Istituto Superiore di Sanita' ORD Immunology NEUROLESI ORD Molecular, Cellular, and Developmental AUXOLOGICO CLI EST Cardiovascular and Respiratory NEUROLESI CLI ORD Brain Disorders and SAN RAFFAELE PISANA ORD Oncology 1 Basic PASCALE ORD Oncology Role of mir in the cytokine mediated regulation of gene expression in neoplastic B cells IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic EPIGENETIC DETERMINANTS OF DRUG SENSITIVITY AND CLINICAL OUTCOME IN OVARIAN CANCER HUMANITAS ORD Oncology Pagina 133 di 332

134 Functional ability and health related behavior among the elderly: an interactive web based surveillance system RIZZOLI CLI ORD Risk, Prevention and Health Behavior Mechanisms of interplay between Mycobacterium avium subspecies paratuberculosis and intestinal cells in Crohn s disease Istituto Zooprofilattico Sperimentale delle Venezie ORD Digestive, Kidney and Urological Systems Italian study on gene environment interactions in lymphoma aetiology: translational aspects New specific calcium inhibitor BZ194 as potential modulator of Myasthenia Gravis Next generation sequencing to speed up molecular diagnosis and to identify novel causes of hemolytic uremic syndrome Prostate cancer and visceral obesity: an epidemiological, hormonal, metabolic and molecular study Exploring the interactome of the high risk Human Papillomavirus oncoproteins to understand and dismantle its oncogenic power IDENTFICATION OF MOLECULAR MARKERS FOR EARLY DIAGNOSIS AND SCREENING OF CHRONIC ALLOGRAFT DYSFUNCTION AND IMMUNE MONITORING IN RENAL TRANSPLANT RECIPIENTS Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity Toscana ORD Oncology 1 Basic CARLO BESTA EST Brain Disorders and Lombardia ORD Genes, Genomes and Genetics Veneto CLI ORD Digestive, Kidney and Urological Systems REGINA ELENA ORD Oncology 1 Basic Veneto ORD Genes, Genomes and Genetics SAN RAFFAELE PISANA ORD Musculoskeletal, Oral and Skin Pagina 134 di 332

135 Functional validation of candidate oncogenes in pancreatic cancer SAN RAFFAELE MONTE TABOR EST Oncology Health (cancer and atherosclerotic) risks from radiological medical imaging in grown up congenital heart disease patients Prospective study in premanifest Huntington disease mutation carriers: new clinical and neuroradiological assessment tools for long term follow up and early signs evaluation REGENERATION OF SCAPHOID BONE DEFICIENCY BY USING AUTOLOGOUS EX VIVO EXPANDED, GMP GRADE, BONE MARROW MESENCHYMAL STEM CELLS Toscana CLI ORD Cardiovascular and Respiratory CARLO BESTA CLI ORD Brain Disorders and Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering Autoreactive T cell expansion profiles and mechanisms in patients with type I diabetes during beta cell replacement therapy SAN RAFFAELE MONTE TABOR ORD Immunology Development of vaccines to control salmonellosis using attenuated strains with altered metal uptake capability Istituto Superiore di Sanita' EST Veterinary Exploiting endoplasmic reticulum aminopeptidases modulation for innovative strategies of anticancer immunotherapy OSPEDALE BAMBINO GESU' EST Immunology Large Scale Maladaptive Neuroplasticity in Chronic Migraine: Implications for Novel Neurophysiological Treatments Normal and pathological development of locomotion in the first year of life SANTA LUCIA CLI ORD Brain Disorders and SANTA LUCIA ORD Brain Disorders and Pagina 135 di 332

136 IN PURSUIT OF NOVEL THERAPEUTIC STRATEGIES FOR NON ALCOHOLIC FATTY LIVER DISEASE: UNDERSTANDING THE ROLE OF LITAF PROTEIN. OSPEDALE BAMBINO GESU' EST Digestive, Kidney and Urological Systems Collaborative model for the psychosocial care of the adult cancer patients and their caregivers: cluster, randomized trial to test a new way of care coordination. (HuCare 2: Humanization of cancer care, project 2) Lombardia CLI ORD Healthcare Delivery and Methodologies EFFECTS OF NUTRITION ON LIPID SIGNALLING IN ALZHEIMER DISEASE Differentiated cardiomyocytes as a source of induced pluripotent stem cells FATEBENEFRATELLI ORD Brain Disorders and MULTIMEDICA ORD Cardiovascular and Respiratory A marker of homeostatic failure locates seizureonset CARLO BESTA ORD Brain Disorders and zone in surgically remediable focal epilepsies Endothelial Dysfunction and Insulin Resistance: an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signaling and cardiovascular damage Identification of gender related differences in oxidative stress biomarkers associated with atherosclerotic disease progression Toscana ORD Cardiovascular and Respiratory Istituto Superiore di Sanita' ORD Cardiovascular and Respiratory Early diagnosis in medicine by SERS nano devices Calabria ORD Bioengineering and Technologies Smart biomimetic constructs with internal SAN DONATO ORD Bioengineering microvasculature for stem cell based cardiac and tissue engineering: a clinical translatable approach. Technologies Pagina 136 di 332

137 CLINICAL AND NEUROLOGICAL MARKERS OF CHANGES IN BORDERLINE PERSONALITY DISORDER FOLLOWING A METACOGNITIVE INTERPERSONAL THERAPY FATEBENEFRATELLI ORD Brain Disorders and Characterization of interactions among tumor, stromal and immune cells for the identification of potential targets in melanoma therapy. IRCCS AOU San Martino IST (Genova) ORD Immunology Interactions of replicating or dormant Mycobacterium tuberculosis with human cells as a preclinical model to disclose new targets of immunointervention against tuberculosis Istituto Superiore di Sanita' ORD Immunology The role of oxidative damage to DNA and its repair in human gastrointestinal cancer Istituto Superiore di Sanita' ORD Oncology 1 Basic Novel immunotherapeutic strategies for the cure of human prostate cancer SAN RAFFAELE MONTE TABOR ORD Immunology Priming Metabolism and Quality Control Pathways to Modulate the Cell Biology of Glioblastoma: Functional Role of the Mitochondrial Translocator Protein (TSPO) Protein profile of red blood cell and exosomes signature for early diagnosis of ovarian cancer Turning expression into advantage: a new tool for regulatory T cell therapy Sacral neuromodulation as treatment of urge incontinence in frail elderly female patients: a study of feasibility, safety and cost effectiveness analysis. REGINA ELENA ORD Cell Biology Veneto ORD Oncology BURLO GAROFALO EST Immunology Lazio CLI ORD Digestive, Kidney and Urological Systems Pagina 137 di 332

138 Extreme Obesity and Sleep Apnoea Syndrome: Redox Balance, Inflammation and Vitamin Profile. Effect of metabolic rehabilitation and non invasive mechanical ventilation. AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive IDENTIFICATION OF NEW DISEASE GENES IN MITOCHONDRIAL COMPLEX I DEFICIENCY OSPEDALE BAMBINO GESU' EST Brain Disorders and Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma and in liver regeneration: mirnome and proteome analysis in experimental and clinical settings Serotonin 7 receptors: prognostic markers and new therapeutic targets for neuro developmental symptoms involving cognition, sleep and mood. Discovery of small molecules capable of eliminating the HIV T cellular reservoir Identification of new genetic variations involved in Bipolar I disorder via all exome sequencing of families with high genetic vulnerability from a founder Sardinian population Istituto Superiore di Sanita' ORD Oncology Istituto Superiore di Sanita' ORD Biobehavioral and Behavioral Processes Istituto Superiore di Sanita' ORD AIDS and Related Research FATEBENEFRATELLI EST Genes, Genomes and Genetics Novel ph sensitive surfactant nanocarriers for tumor targeted drug delivery and cellular imaging as potential therapeutic and diagnostic tools for rare pediatric tumors OSPEDALE BAMBINO GESU' ORD Bioengineering and Technologies COPD global proteomics: a systems biology approach. SAN RAFFAELE PISANA ORD Cardiovascular and Respiratory Pagina 138 di 332

139 Juvenile ALS and motor neuron degeneration: a comprehensive approach to improve diagnosis and to understand disease pathogenesis through the use of cellular and animal models Next Generation Targeted resequencing Panels as a tool for multi gene testing in the diagnosis of Parkinson Disorder MEDEA ORD Brain Disorders and SAN RAFFAELE PISANA ORD Genes, Genomes and Genetics Roles of ADP ribosylation in the regulation of the actin cytoskeleton and intracellular Ca2+ signaling Abruzzo ORD Cell Biology Bisphosphonates as novel adjuvants to enhance adaptive immune responses SAN RAFFAELE MONTE TABOR ORD Immunology Effective functional measurements in musculoskeletal rehabilitation: guidelines, methodologies and tools for accreditation, assessment and appropriate performance of Movement Analysis Laboratories Istituto Superiore di Sanita' ORD Musculoskeletal, Oral and Skin Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary Scaffold assisted mesenchymal stem cells therapy for cartilage tissue engineering Investigating Huntington disease stage related biomarkers in the nervous and cardiovascular systems Individual risk for lung cancer and low dose CT Scan screening for occupationally ex exposed to asbestos. GALEAZZI EST Musculoskeletal, Oral and Skin NEUROMED CLI ORD Brain Disorders and Toscana CLI ORD Oncology Pagina 139 di 332

140 Role of purinergic receptor P2X7R in ischemic tissue damage and collateral vessels development Prospective, Randomized, Multi Center Trial of Lateral Trendelenburg versus Semi Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator Associated Pneumonia UNRAVELING MECHANISMS UNDERLYING THE RECOVERY OF WALKING ABILITY IN STROKE SURVIVORS Hereditary spastic paraplegia: generation of cellular and animal models to dissect the complex interplay of the pathways involved combined with novel tools for disease diagnosis Adipocyte derived leptin as a new tool to manipulate immune response in Tuberculosis Health impact assessment and health care costs of respiratory tract infections (RTI) in general population and hospitalized patients in Palermo (Western Sicily). Cerebellar transcranial magnetic stimulation as a treatment option for levodopa induced dyskinesias and tremor A defect in TLR7 gene expression impaires innate and adaptive immunity in Multiple Sclerosis patients: intracellular mechanisms as therapeutic targets ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROTICS SAN RAFFAELE PISANA EST Cardiovascular and Respiratory MAGGIORE CLI EST Infectious Diseases and Microbiology Emilia Romagna CLI EST Brain Disorders and MEDEA EST Brain Disorders and Istituto Superiore di Sanita' EST Infectious Diseases and Microbiology Sicilia CLI ORD Infectious Diseases 12, and Microbiology NEUROMED CLI ORD Brain Disorders and 12, Istituto Superiore di Sanita' EST Immunology 12, Lombardia CLI ORD AIDS and Related 12, Research Pagina 140 di 332

141 Readthrough of Premature Termination Codons to treat Kabuki syndrome CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 12, and Genetics Exploring Ng MIP Neisseria gonorrhoeae Macrophage Infectivity Potentiator) and Ng OMPA (Neisseria gonorrhoeae Outer Membrane Protein A) as novel candidates to fight gonococcal infection due to resistant or multi drug resistant gonococci Malignancy and invasiveness molecular determinants in oro pharyngeal squamous cell carcinomas. INTERMED Self Assessment Study (IMSAS) Selfassessed clinical evaluation of bio psycho social complexity Physiological effects of extracellular guanosine triphosphate (GTP) on renal cells and water transport CLINICAL IMPACT OF TISSUE AND CIRCULATING MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF THYROID CANCER ROLE OF PERFUSION COMPUTED TOMOGRAPHY(PCT)AND VASCULAR ENDOTHELIAL GROWTH FACTOR A(VEGF A)SERUM LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS(HGG):NEW METHODS OF MONITORING TREATMENT? Exposure to occupational carcinogens and pathogenetic mechanisms in sinonasal adenocarcinomas Istituto Superiore di Sanita' ORD Infectious Diseases 12, and Microbiology REGINA ELENA ORD Oncology 1 Basic 12, Emilia Romagna CLI EST Healthcare Delivery 12, and Methodologies Abruzzo ORD Cell Biology 12, Toscana CLI ORD Oncology 2 12, NEUROMED CLI ORD Oncology 1 Basic 12, Piemonte CLI ORD Oncology 1 Basic 12, Pagina 141 di 332

142 Advanced diagnostics and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD). Role of multiple HPV infections in the development of cervical diseases. RELATIOSHIPS BETWEEN VASOACTIVE MEDIATORS AND HEMODYNAMIC ALTERATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS. ULTRA HIGH FIELD(7T)MAGNETIC RESONANCE SYSTEM: NEUROMUSCOLAR APPLICATIONS Identification of biomarkers able to predict malignant transformation of dysplastic nodules in the cirrhotic liver. Nanotecnology based drug delivery : new generation nanovector for drug delivery in human bone diseases. NEUROLESI CLI ORD Musculoskeletal, 12, Oral and Skin BURLO GAROFALO CLI EST Infectious Diseases 12, and Microbiology Toscana CLI ORD Brain Disorders and 12, STELLA MARIS CLI EST Brain Disorders and 12, HUMANITAS ORD Oncology 2 12, GALEAZZI ORD Musculoskeletal, 12, Oral and Skin Efficacy of nicotine dependence pharmacotherapy based on individual pharmacokinetic profile and identification of pharmacogenetic determinants of drug response Toscana CLI ORD Brain Disorders and 12, TOOLS FOR THE IMPROVEMENT OF ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES: AN INTERVENTION STUDY DON GNOCCHI CLI ORD Risk, Prevention 12, and Health Behavior Pagina 142 di 332

143 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS The therapeutic potential of natural and synthetic agonists of PPAR gamma as adjuvant and dietary supplementations in the cure of demyelinating diseases Experimental studies and preclinical applications of Endothelial Differentiation of Amniotic Fluid Derived Stem Cells : a promising new therapeutic strategy for stroke MOLECULAR EVENTS IN MELANOMA PROGRESSION: REGULATION OF AP 2 TARGET GENES AND INVOLVEMENT IN TUMOR GROWTH AND METASTASIS. Humanization of Emergency Departments in Local Healthcare Authority TO3 Piedmont Region: new features and patient satisfaction Effect of matrix metalloproteinases on the integrity and functions of anti tumor necrosis factor (TNF) alpha agents: possible correlation with response to anti TNF alpha treatment in inflammatory bowel disease patients ANALYSIS OF PROGNOSTIC AND PREDICTIVE FACTORS AND DEVELOPMENT OF AN ONCOMETABOLITE AS MARKER IN PATIENTS WITH MALIGNANT GLIOMAS Lombardia ORD Interdisciplinary 12, Molecular and Training Istituto Superiore di Sanita' ORD Molecular, Cellular, 12, and Developmental Abruzzo ORD Emerging Technologies and Training in s 12, Piemonte ORD Oncology 2 12, Piemonte CLI ORD Healthcare Delivery 12, and Methodologies SAN MATTEO ORD Digestive, Kidney 12, and Urological Systems I. O. V. ORD Brain Disorders and 12, Unravelling the susceptibility to develop rotator cuff tears and its role onto surgical outcome OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 12, Oral and Skin Pagina 143 di 332

144 The ADP receptor P2Y13 in the regulation of megakaryocytes development in myeloproliferative neoplasms Pharmacological approaches to improve the thymic defect and prevent autoimmunity in a murine model of Omenn syndrome: therapeutic implications. Modularity for sensory motor control: implications of muscles synergies in motor recovery after stroke. Effects of high intensity robot assisted training in hand function recovery and ADL independence after stroke: a multicentre randomized controlled single blind trial FK 506 Pharmacogenetics/Pharmacogenomics and new approaches in FK 506 therapeutic drug monitoring in pediatric and adult liver transplantation Lombardia CLI ORD Vascular and 12, Hematology HUMANITAS ORD Immunology 12, S.CAMILLO CLI EST Biobehavioral and 12, Behavioral Processes SAN RAFFAELE PISANA CLI ORD Brain Disorders and 12, Piemonte EST Immunology 12, Identification and evaluation of markers of malignancy in thyroid nodules with undetermined cytology BURLO GAROFALO CLI ORD Oncology 1 Basic 12, Transcranial magnetic stimulation over parietal cortex to restore altered somatosensory processing in patients with dystonia. NEUROMED CLI ORD Brain Disorders and 12, Validation of a new algorithm for HPV status assessment in head and neck carcinoma ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12, Functional studies of deregulated micrornas in Sezary Syndrome ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic 12, Pagina 144 di 332

145 Biological aging in dilated cardiomyopathy and chronic obstructive pulmonary disease Strategies to improve functional recovery in presence of cerebellar pathology Relevance of host factors in the pathogenesis of HCV related lymphoproliferative disorders Veneto ORD Cardiovascular and 12, Respiratory SANTA LUCIA ORD Biobehavioral and 12, Behavioral Processes Toscana ORD Oncology 1 Basic 12, Effects of Neuropeptide Y on the central nervous SANTA LUCIA ORD Brain Disorders and 12, system neurons of rat models of Alzheimer Disease ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES SDN CLI ORD Genes, Genomes 12, and Genetics CLINICAL AND PHARMACOLOGICAL EVALUATION OF TRABECTEDIN (T) IN BRCA MUTATION CARRIER AND BRCANESS PHENOTYPE OVARIAN CANCER PATIENTS ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12, Development of a novel lubricating gel containing antimicrobial loaded nanoparticles to prevent urinary catheter associated infections particularly in patients with neurogenic bladder requiring long term catheterization. WAC Project (Web Based Asthma Control) evaluation of the utility of a web based electronic health diary to improve control of moderatesevere asthma SANTA LUCIA CLI ORD Infectious Diseases and Microbiology 12, Toscana CLI ORD Cardiovascular and 12, Respiratory A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATIONS IN ATM, OCT and MATE GENES IN THE GLYCAEMIC RESPONSE TO METFORMIN IN DRUG NAÏVE TYPE 2 DIABETIC PATIENTS AUXOLOGICO ORD Genes, Genomes 12, and Genetics Pagina 145 di 332

146 Role of Human Papilloma Virus in Head and Neck Cancer. A model for benchmarking cancer care management among different organizational settings in view of harmonization mirnas controlling telomere function in cancer "telo mirnas" MicroRNA replacement therapy for the treatment of Neuroblastoma Seven In Absentia Homologue (SIAH) Interaction with Na+/Ca2+ Exchanger and A Kinase Anchoring Protein (AKAP) to Identify new Druggable Targets for the Treatment of Cerebral Ischemia The endocannabinoid system as target in colon cancer and associated cachexia MEDITERRANEAN DIET, PHYTO ESTROGENS AND RECURRENCE OF COLORECTAL ADENOMAS. A MULTICENTER RANDOMIZED CONTROLLED TRIAL. PLASMA EXOSOMES IN THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES: MiRNA SEQUENCING AND PROTEOMICS I.E.O. EST Infectious Diseases 12, and Microbiology Piemonte CLI ORD Healthcare Delivery 12, and Methodologies Lazio ORD Oncology 1 Basic 12, Liguria ORD Oncology 2 12, SDN ORD Molecular, Cellular, 12, and Developmental NEUROLESI ORD Digestive, Kidney 12, and Urological Systems DE BELLIS EST Oncology 2 12, Istituto Superiore di Sanita' ORD Brain Disorders and 12, Definition of the prognostic and biological roles of tissue associated and soluble biomarkers in epithelial ovary cancer exploiting well characterized retrospective and prospective clinical series of samples ISTITUTO TUMORI MILANO ORD Oncology 2 12, Pagina 146 di 332

147 BOOSTING COGNITIVE FUNCTIONS IN ADHD PATIENTS USING NON INVASIVE ELECTRICAL STIMULATION OSPEDALE BAMBINO GESU' ORD Integrative, Functional, and Cognitive 12, Nociceptin/Orphanin FQ as a biomarker for Parkinson s disease Friuli Venezia Giulia CLI ORD Brain Disorders and 12, Whole genome study of gastrointestinal stromal tumors (GISTs), abdominal soft tissue sarcoma and rare tumors using next generation DNA sequencing approach for optimizing the diagnosis, prognosis, classification and treatment Emilia Romagna ORD Oncology 1 Basic 12, The role of microbial agents in prostate cancer pathogenesis Dissecting the molecular bases and clinical variability of familial Alzheimer's disease Arbovirus infections in humans and vectors: potential for local outbreaks in Northern Italy EBV reactivation and CD8+ T cell responses in Multiple Sclerosis Sensory plasticity of the adult human brain and recovery after stroke: behavioural and neurophysiological markers C.R.O. AVIANO EST Oncology 2 12, Istituto Superiore di Sanita' ORD Brain Disorders and 12, SAN MATTEO ORD Infectious Diseases 12, and Microbiology SANTA LUCIA CLI ORD Immunology 12, FATEBENEFRATELLI ORD Brain Disorders and 12, Microbiota induced MAIT cells and Autoimmunity SANTA LUCIA ORD Immunology 12, Pagina 147 di 332

148 The mutant p53/id4 axis controls the cross talk between breast cancer cells and tumor associated macrophages: study of its involvement in the control of tumor neoangiogenesis and invasiveness. Home based palliative care for people with severe multiple sclerosis: Developmental and pilot phases of the Palliative Network for Severely Affected Adults with MS in Italy (PeNSAMI) study Role of dual purinergic/cysteinyl leukotrienes receptor GPR17 in inflammatory conversion of cardiac resident progenitors following myocardial ischemia REGINA ELENA ORD Oncology 1 Basic 12, CARLO BESTA CLI ORD Brain Disorders and 12, MONZINO ORD Cardiovascular and 12, Respiratory Harnessing Innate Immunity Against Influenza A: Investigation of Tripartite Motif 22 Mediated Inhibition of Viral Replication SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 12, and Microbiology Role of alternative polyadenylation in cancer SANTA LUCIA ORD Genes, Genomes 12, and Genetics GADD45beta cell permeable inhibitor peptide against cerebral ischemia Molecular characterization of the epithelialmesenchimal transition process underlying idiopathic pulmonary fibrosis and lung cancer. Mechanisms of mood control by inflammatory cytokines in Multiple Sclerosis. micrornas as early biomarkers of anthracyclines induced cardiotoxicity Lombardia ORD Brain Disorders and 12, SAN MATTEO EST Cardiovascular and 12, Respiratory SANTA LUCIA CLI ORD Brain Disorders and 12, MONZINO ORD Cardiovascular and 12, Respiratory Pagina 148 di 332

149 Whole transcriptome changes induced by vaccineelicited immune responses in melanoma patients: providing the rationale for the development of dynamic antigen updating of dendritic cell vaccines Emilia Romagna ORD Immunology 12, Mast cells translate external challenges into immune regulation affecting colitis and colorectal cancer. ISTITUTO TUMORI MILANO ORD Immunology 12, Pathogenesis of West Nile virus infection: a balance between virulence, innate immunity and viral evasion Characterization of new molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian cancers Inflammation and cancer: relevance of chemokines in myeloid cells recruitment, activation and cross talk with NK cells in tumor biology Understanding the adaptive immune response defects of WHIM syndrome patients Emilia Romagna ORD Infectious Diseases 12, and Microbiology CROB ORD Oncology 2 12, HUMANITAS ORD Immunology 12, HUMANITAS ORD Immunology 12, Multiple gene analysis in bronchoscopic specimens from patients with advanced non small cell lung cancer I.E.O. CLI ORD Oncology 2 12, Isolation and characterization of ependymalderived stem/progenitor cells (epspcs): a new in vitro model to address pathogenesis and treatment of motor neuron diseases. CARLO BESTA ORD Brain Disorders and 12, Pagina 149 di 332

150 Immunogenic cell death as predictive and realtime marker of response to EGFR targeted therapy in CRC patients Exploring the role of drusen in the retinas as possible markers for the Alzheimer s disease pathology: a multidisciplinary approach. Pathway association and genetic interaction analysis for genome wide association study of cerebrovascular ischemic diseases in the Italian population I.E.O. ORD Oncology 2 12, Istituto Superiore di Sanita' ORD Brain Disorders and 12, CARLO BESTA CLI EST Genes, Genomes 12, and Genetics ENDOGENOUS OUABAIN IS IMPLICATED IN ACUTE KIDNEY INJURY IN CARDIAC SURGERY AND CRITICALLY ILL PATIENTS: A METABOLOMIC STUDY SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 12, and Urological Systems IDENTIFICATION OF NEW DISEASE GENES ASSOCIATED WITH BRUGADA SYNDROME BY WHOLE EXOME SEQUENCING SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 12, Respiratory Identification of clinical and genetic factors for personalized opioid therapy of cancer pain ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12, Phenotypic characterization and genomic sequencing in schizophrenia Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus SAN RAFFAELE PISANA EST Genes, Genomes 12, and Genetics Istituto Superiore di Sanita' ORD Immunology 12, Molecular and Functional Characterization of a Polycystin/Nephrocystin Complex SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney 12, and Urological Systems A proteomic and lipidomic approach to discover diagnostic and predictive markers of lung cancer. Emilia Romagna ORD Oncology 2 12, Pagina 150 di 332

151 Predictive biomarkers of melanoma progression and clinical response to chemoimmunotherapeutic therapies using new medical imaging approaches SAN GALLICANO ORD Oncology 2 12, CREATION OF A NATIONAL NETWORK FOR Emilia Romagna CLI ORD Oncology 2 12, THE DIAGNOSIS OF MALIGNANT LYMPHOMAS Predictive value of FDG PET/CT Metabolic Tumour Volume in patients treated with neoadjuvant chemoradiation therapy for locally advanced rectal cancer Co Amplification of the ERBB2 and RARA genes in breast cancer: a potential target for retinoidbased therapy Liguria CLI ORD Oncology 2 12, MAUGERI CLI ORD Oncology 2 12, Evaluation of the effectiveness of ADL based exercises Vs point to point reaching tasks in robot mediated therapy of the upper limb for subacute stroke patients SAN RAFFAELE PISANA CLI ORD Emerging Technologies and Training in s 12, FRACTURE UNIT MULTIREGIONAL EXPERIMENTATION PROJECT (FRAME Project) ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES: A MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS Toscana CLI ORD Healthcare Delivery 12, and Methodologies MONDINO CLI ORD Brain Disorders and 12, Development and assesment of a regional palliative care network. The Ligurian Palliative Care Demonstration Project. IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery 12, and Methodologies Pagina 151 di 332

152 Role of stromal cells in lymphoma mediated immunosuppression: a novel target for the treatment. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 12, Parkinson's Disease: a new approach to motor and cognitive neurorehabilitation FATEBENEFRATELLI ORD Brain Disorders and 12, Integrated risk assessment for food safety emerging risks in sustainable farming systems (IRASF) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 12, Investigation of B cell function and diversity in patients with SCID X1 following HSCT or gene therapy Toscana EST Immunology 12, Characterization of behavioral and neuronal SANTA LUCIA ORD Brain Disorders and 12, alterations in the prodromal phase of Parkinson's disease to prevent dopamine neurons degeneration NON INVASIVE BRAIN STIMULATION AS ADJUVANT THERAPY FOR ALZHEIMER DISEASE Adipose tissue remodelling from white to brown phenotype as preventive treatment for type 2 diabetes and as potential tool to protect against metabolic diseases of aging. MAGGIORE CLI ORD Brain Disorders and 12, SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive 12, Contribution of fibroblast derived micrornas to prostate and lung cancer aggressiveness ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 12, The role of PlGF/VEGFR1 pathway in the regulation of inflammatory response and vascular rarefaction in hypertension. NEUROMED ORD Vascular and 12, Hematology Pagina 152 di 332

153 STem cells Mobilization in Acute Myocardial Infarction Outcome Trial (STEM AMI OUTCOME Trial): efficacy and functional substudies Lombardia CLI ORD Cardiovascular and 12, Respiratory Evaluation of a multi marker strategy in the clinical management of children with congenital heart disease undergoing cardiac surgery. Integrated lipidomic profiling in diabetes, cardiovascular disease and cancer in a cohort of subjects in a mediterranean area of southern Italy: a nested case control study. BDNF polymorphism, calprotectin and clinical phenotype in Rett syndrome Identification of novel causative genes for developmental brain disorders mapping in the 6q27 chromosomal region. Modeling Alzheimer s disease through ips technology A randomized intervention study to assess the effect of the Mediterranean Diet on plasma fatty acid profile. Role of mir 155 in FLT3 ITD mutated acute myeloid leukemia: studies of network, signalling and silencing. GOAL DIRECTED PERFUSION AND ACUTE KIDNEY INJURY IN CARDIAC SURGERY A RANDOMIZED, CONTROLLED TRIAL Toscana ORD Cardiovascular and Respiratory DE BELLIS COF Population and Epidemiology Toscana CLI ORD Brain Disorders and Toscana CLI ORD Brain Disorders and FATEBENEFRATELLI ORD Brain Disorders and MONZINO CLI ORD Cardiovascular and Respiratory Sicilia ORD Oncology 1 Basic SAN DONATO CLI COF Surgical, Biomedical Imaging, and Bioengineering Pagina 153 di 332

154 Internet addiction disorder in adolescents: identification of possible biological and personality markers Sgk1: a novel regulator of genomic stability in human cancer Toscana ORD Brain Disorders and Calabria ORD Oncology 1 Basic Bone structure in blood malignancies IRCCS AOU San Martino IST (Genova) ORD Bioengineering and Technologies Molecular markers and pathogenic mechanisms of the emerging Beijing genotype of Mycobacterium tuberculosis Novel therapeutic perspectives for angioedema associated with C1 inhibitor deficiency or angiotensin converting enzyme inhibitor treatment Characterization and validation of new prognostic markers in high grade ovarian cancer. Modulation of pharmacogenomic and pharmacodynamic biomarkers of glucose metabolism by metronomic chemotherapy in cancer and endothelial cells Modulation of immune (T cell) response to islet autoantigens by human mesenchymal stem cellderived microvesicles Prediction of reading acquisition disorders using behavioral and neurobiological markers Toscana ORD Infectious Diseases and Microbiology BURLO GAROFALO CLI ORD Vascular and Hematology C.R.O. AVIANO ORD Oncology 1 Basic Toscana EST Oncology Piemonte ORD Immunology MEDEA CLI ORD Risk, Prevention and Health Behavior Haemophilia arthropathy (HA) and Ultrasound (US): development and first validation steps of the simplified HEAD US score Liguria CLI COF Musculoskeletal, Oral and Skin Pagina 154 di 332

155 Towards communication in vegetative and minimally conscious state patients. Semantic classical conditioning and brain computer interface control CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF EPITHELIAL SKIN CANCERS Effects of conventional rehabilitation terapy and combined restorative interventions in patients with post stroke deficits of the upper limb ROLE OF HOST AND VIRAL FACTORS ON THE EXPERIMENTAL INFECTIONS OF CYNOMOLGUS MACAQUES WITH SIMIAN OR SIMIAN HUMAN IMMUNODEFICIENCY VIRUS. Evaluation of chemotherapy induced cardiotoxicity utilizing cardiac byomarkers doppler echocardiography and Magnetic Resonance Imaging Indoleamine 2,3 Dioxygenase and Peripheral Tolerance to Exogenous Factor VIII:A Multi Centre Study Multiplex Ligation Probe Amplification (MLPA) analysis, 5p 13.2 Loss Of Heterozygosity (LOH),CA SSR1 EGFR microsatellite analysis and NIPBL Illumina Solexa sequencing in Thymic Epithelial Tumors and Squamous Cell Lung Carcinomas metastatic to the medias S.CAMILLO CLI ORD Biobehavioral and Behavioral Processes MAUGERI CLI ORD Surgical, Biomedical Imaging, and Bioengineering S.CAMILLO CLI ORD Brain Disorders and Istituto Superiore di Sanita' ORD AIDS and Related Research Lazio ORD Brain Disorders and Umbria EST Vascular and Hematology REGINA ELENA ORD Oncology 1 Basic Pagina 155 di 332

156 FROM HUMAN TO CANINE. SERUM TUMOUR MARKERS EXPRESSION IN MAMMARY CANCER: NEW PERSPECTIVE IN VETERINARY ONCOLOGY? Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary ROLE OF NEUROPILIN 1 IN THE PROGNOSIS AND THERAPEUTICS OF HUMAN MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic Continuity of mental disorders from childhood to early adulthood in Emilia Romagna and Piemonte: comparison with the Danish population Longitudinal advanced EEG evaluation and noninvasive neuromodulation in patients in vegetative state Emilia Romagna CLI ORD Risk, Prevention and Health Behavior Sicilia CLI ORD Brain Disorders and Therapeutic potential of High Density Lipoprotein (HDL) associated lysosphingolipids in arteriosclerosis Biological and biomechanical experimentation using a new vetro ceramic scaffold for bone regeneration in order to evaluate surgical and pharmacological treatments before testing on the patient. Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of associated carcinogenic risk New candidate gene for hemiplegic migraine and episodic ataxia Autophagy: a pro apoptotic or pro survival pathway in Amyotrophic Lateral Sclerosis (ALS)? Emilia Romagna ORD Vascular and Hematology Piemonte ORD Bioengineering and Technologies Istituto Superiore di Sanita' ORD Oncology 1 Basic Lazio ORD Genes, Genomes and Genetics SANTA LUCIA ORD Molecular, Cellular, and Developmental Pagina 156 di 332

157 FORCING THE BLOOD BRAIN BARRIER FOR CANCER CHEMOTHERAPY Neurophysiologic, genetic and neuroimaging features of Gilles de la Tourette Syndrome and Obsessive Compulsive Disorder Metabotropic glutamate receptors as a target for the treatment of Amyotrophic Lateral Sclerosis Type 3 metabotropic glutamate receptors expressed by cancer stem cells as drug targets in the experimental treatment of malignant gliomas The response to intestinal microbiota in peripheral blood and gut mucosa from patients with Crohn's Disease: from the definition of immune profiles to the development of induced pluripotent stem cells for pharmacologic studies. Toscana ORD Oncology NEUROMED CLI ORD Brain Disorders and NEUROMED COF Brain Disorders and NEUROMED COF Brain Disorders and BURLO GAROFALO CLI ORD Digestive, Kidney and Urological Systems Phase II trial of fulvestrant and gefitinib combination in patients with EGFR mutations who failed a first line with EGFR Tyrosine Kinase Inhibitors (TKIs) ISTITUTO TUMORI MILANO CLI COF Oncology Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications A randomized multicenter study to compare the efficacy of additional tumor debulking surgery versus chemotherapy (CT) alone for recurrent platinum(p) sensitive ovarian cancer (OC) STELLA MARIS ORD Surgical, Biomedical Imaging, and Bioengineering PASCALE CLI ORD Oncology Pagina 157 di 332

158 Investigation of the expression and functional role of caveolin 1 and Polymerase I and Transcript Release Factor (PTRF)/cavin 1 in rhabdomyosarcomas. "Distribution of allelic polymorphism (TAAA)n in the Sex Hormone Binding Globulin (SHBG) gene in breast cancer patients with or without hormone therapy:relations with SHBG plasma levels and nutrictional factors". Functional and effective connectivity evaluation in drug resistant epileptic patients candidates to surgery.a new tool for identification of the seizure onset zone and prediction of memory and cognitive outcome. DEVELOPMENT IN ACUTE MYELOID LEUKEMIA PATIENTS OF A GENOMIC TEST BASED ON PROFILING OF APOPTOTIC MACHINERY AND OF mi RNA FOR REFINEMENT OF PROGNOSTIC RISK CLASSIFICATION AND TO GUIDE POST REMISSIONAL THERAPEUTIC STRATEGY Ex vivo studies on hyperhomocysteinemiainduced epigenetic modifications as potential biomarkers for early diagnosis of Alzheimer s disease and other dementia related disorders Fatigue relief in Multiple Sclerosis by transcranial Direct Current neurostimulation (tdcs). [FaMuSne] Mechanisms and actions of Regorafenib, a new hepatoma (HCC) therapy Lombardia ORD Oncology 1 Basic ONCOLOGICO DI BARI CLI ORD Genes, Genomes and Genetics Toscana CLI ORD Brain Disorders and Sicilia ORD Oncology Sicilia ORD Molecular, Cellular, and Developmental SAN RAFFAELE PISANA ORD Brain Disorders and DE BELLIS ORD Oncology Pagina 158 di 332

159 The development and progression of Mild Cognitive Impairment in Parkinson s disease: a multimodal neuroimaging study to detect markers able to predict the conversion to dementia. SAN RAFFAELE MONTE TABOR CLI ORD Biobehavioral and Behavioral Processes Analysis of pattern recognition receptor activation in cognitively impaired subjects ELUCIDATION OF IN VIVO CORRECTION TO WILDTYPE MECHANISM OF HERITABLE MUTATIONS IN HUNTER DISEASE Identification and pathways to care of children with complex or chronic health conditions and special health care needs Whole exome resequencing in familial Neural Tube Defects SANTA LUCIA EST Brain Disorders and GASLINI ORD Genes, Genomes and Genetics Emilia Romagna CLI ORD Healthcare Delivery and Methodologies GASLINI ORD Genes, Genomes and Genetics Therapeutic strategies in refractory chronic daily headache: A multicenter, open, randomized, controlled trial. Istituto Scienze Neurologiche CLI ORD Emerging Technologies and Training in s Gender related differences in fibromyalgia: role of oxytocin mediated neurotransmission Colorectal cancer: Vitamin D, VDR and beta Catenin expression study: from biological pathways to clinical prevention. Proteomics of benign and malignant parathyroid tumors: identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer FATEBENEFRATELLI ORD Molecular, Cellular, and Developmental I.E.O. CLI ORD Oncology Toscana ORD Oncology 1 Basic Pagina 159 di 332

160 The PDE5 cgmp PKG system in adipose tissue: a potential novel target for therapies aimed to fight obesity and metabolic syndrome SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive Genomic approach to understand hereditary angioedema as a periodic disease triggered by stress. Investigation on the molecular correlates of autonomic nervous system stimulation Potential relevance of HLA G, gelatinases and herpes viruses as markers of tumor invasion and progression and their association with CT and MRI perfusion findings in patients with high grade glioma Hydrogen sulphide (H2S) as a novel player in endothelial dysfunction associated to hypertension Lombardia ORD Genes, Genomes and Genetics Emilia Romagna ORD Brain Disorders and SAN RAFFAELE PISANA ORD Cardiovascular and Respiratory TLR2 at the crossroads between infections and Multiple Sclerosis in human and experimental pathology Effect of dopamine treatment on neurocognitive functioning in Parkinson s disease: a fmri study Effects of pharmacological/non pharmacological interventions on collateral flow in acute ischemic stroke Lazio EST Immunology SANTA LUCIA EST Brain Disorders and Lazio CLI ORD Brain Disorders and Virus evolution and virus host interaction in the pathogenesis of severe influenza virus A infections SAN MATTEO ORD Infectious Diseases and Microbiology From personality to molecular mechanisms through neurocognitive phenotypes: a translational study of liability to compulsive drugseeking SANTA LUCIA EST Brain Disorders and Pagina 160 di 332

161 Novel combinatorial therapeutic approach targeting cancer associated fibroblasts derived GDF15 protein in prostate cancer models Combined use of transcranial direct current stimulation and speech therapy to treat patients with aphasic stroke: short and long term effects on anomia Prediction of cerebral outcome after extracorporeal circulation: a combined EEG TMS study Involvement of dysregulated OPG/RANK/RANKL axis in atherogenesis and acute coronary syndromes PASCALE ORD Oncology 1 Basic MAUGERI CLI ORD Emerging Technologies and Training in s SAN RAFFAELE PISANA CLI ORD Brain Disorders and Veneto ORD Vascular and Hematology Development and evaluation of a reverse transcriptase Real Time PCR assay for the study of the presence of viable Toxoplasma gondii in vegetable and meat Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary Understanding the function of WRNIP1 in the maintenance of common fragile site stability and in lung cancer development Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) Identification of measurable biomarkers of vascular ageing: a System Biology Approch Istituto Superiore di Sanita' ORD Oncology 1 Basic Veneto ORD Vascular and Hematology Puglia ORD Vascular and Hematology User participation in payment of health treatments(co payement) Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery and Methodologies Pagina 161 di 332

162 Cytoreduction and Hipec in the treatment of OvaRIaN cancer CHORINE StudyStage IIIC unresectable epithelial ovarian/tubal cancer with partial or complete response after 1st line neoadjuvant chemotherapy (3 cycles CBDCA+Paclitaxel): a phase 3 pros CHRONIC KIDNEY DISEASE (CKD) AND CARDIOVASCULAR RISK. MOLECULAR MECHANISMS, CLINICAL IMPLICATIONS AND NEW PREVENTIVE STRATEGIES Splicing variants of L1CAM in human cancer cells: functional relevance in modulating NK cellmediated anti tumor activity. Pulmonary Valve Implantation using Selfexpanding Tissue Valve without Cardiopulmonary Bypass: a Controlled Randomised Trial Intracellular mechanisms of resistance to somatostatin and dopamine receptor agonists in neuroendocrine tumors Hybrid revascularisation by combined CABG and PCI in multivessel coronary disease: clinical outcomes and optimal management. An observational study. Lombardia CLI ORD Oncology Lombardia CLI ORD Digestive, Kidney and Urological Systems HUMANITAS ORD Immunology MAGGIORE CLI EST Surgical, Biomedical Imaging, and Bioengineering MAGGIORE CLI ORD Oncology SAN RAFFAELE PISANA CLI ORD Cardiovascular and Respiratory In vivo modeling glioblastoma to identify new therapeutic targets and assay a novel oncolytic therapy IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic NMR spectroscopy for metabolism based classification of glioblastoma derived stem cells Istituto Superiore di Sanita' ORD Oncology Pagina 162 di 332

163 Repeated influenza A infections as a risk factor for the development of Parkinson s disease during aging SAN RAFFAELE PISANA ORD Infectious Diseases and Microbiology Semicarbazide sensitive amine oxidases (SSAOs) and matrix degrading metalloproteases (MMPs): a multidisciplinary study of their possible contribution to cerebral amyloid angiopathy (CAA) in Alzheimer's disease. SAN RAFFAELE PISANA CLI ORD Brain Disorders and LOGICAL BANK TO IDENTIFY MARKERS OF DISEASE ACTIVITY RELATED TO CLINICAL VARIABLES AND MODIFYING DRUGS IN MULTIPLE SCLEROSIS CLINICAL IMPACT OF CIRCULATING TUMOR CELLS AND MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF SOLID TUMORS The link between inflammation, synaptic alterations and neurodegeneration in experimental and human multiple sclerosis Emilia Romagna CLI ORD Brain Disorders and Toscana CLI ORD Oncology SANTA LUCIA CLI ORD Brain Disorders and Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in the Italian NHS Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery and Methodologies Biomaterial functionalization to improve biofunctionality and osteointegration of medical devices for healthy and osteopenic bone. Analysis of macrophage and neutrophil subpopulations in the vascular remodelling occurring in HCC genesis and progression. Implications for early diagnosis, prognosis and therapy. RIZZOLI ORD Musculoskeletal, Oral and Skin HUMANITAS ORD Oncology Pagina 163 di 332

164 Experimental models for investigation of interrelationship between CSCs/TICs and metastasis A New Nonsurgical Treatment for Type 2 Diabetes in Obese Patients: Endobarrier versus Intragastric Balloon. A Prospective Randomized Trial and biological studies on the increased thyroid cancer incidence in the volcanic area of Sicily. Role of host pathogen interplay in genital cancer pathogenesis: gene mutations and nucleotide polymorphisms as determinants of cancer susceptibility and response to therapy A novel in vivo model to study molecular determinants in lymphopoietic disorders Molecular bases of phenotypic heterogeneity of Alzheimer's disease: diagnostic and therapeutic implications Explaining coronary heart disease mortality trend in Italy between 2000 and 2010 and forecasting health and economic scenarios for prevention strategies Emilia Romagna ORD Oncology 1 Basic Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Sicilia CLI ORD Oncology PASCALE ORD Oncology 1 Basic C.R.O. AVIANO EST Oncology 1 Basic CARLO BESTA EST Brain Disorders and Istituto Superiore di Sanita' ORD Population and Epidemiology The use of Nanoparticles in food technology: release assessment and development of analytical methods through selected case studies Istituto Zooprofilattico Sperimentale delle Venezie ORD Bioengineering and Technologies COMBINATORIAL IMMUNOLOGICAL AND NANOPARTICLE MEDIATED TARGETING OF THE EARLY STEPS OF THE METASTATIC DISEASE C.R.O. AVIANO ORD Oncology 1 Basic Pagina 164 di 332

165 MOLECULAR AND FUNCTIONAL PROFILES OF NON SELF SUFFICIENCY ELDERLY:FROM DIAGNOSIS TO CARE MODELS Predictive value of heart rate viariability in fetuses of high risk pregnancies. Development of a new method for accurate and rapid signal detection and analysis. Calabria CLI ORD Healthcare Delivery and Methodologies Friuli Venezia Giulia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive NAD dependent signaling as a target in cerebrovascular disease: a preclinical assessment in mouse disease models IRCCS AOU San Martino IST (Genova) EST Brain Disorders and IMmunity, Inflammation and Carotid ATherosclerosis: the IMICAT study NANOSTRUCTURED SCAFFOLD TO ENHANCE NERVE REGENERATION Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology Multi Structured Data Analysis for Patient Specific Human Ligaments Modelling MONZINO ORD Vascular and Hematology Toscana ORD Bioengineering and Technologies SAN RAFFAELE PISANA ORD Brain Disorders and RIZZOLI ORD Surgical, Biomedical Imaging, and Bioengineering Whole ovary or isolated oocyte controlled exposure to environmental contaminants and radiation sources in farm animals Impact on animal production and translational research for human reproductive medicine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 165 di 332

166 MODULATION OF POST TRANSLATIONAL MODIFICATIONS AND QUALITY CONTROL SYSTEMS AS A NOVEL THERAPEUTIC STRATEGY FOR PROTEIN MISFOLDING DISEASES Non cancer (atherosclerotic, neurocognitive, reproductive) health effects of chronic low dose radiation exposure in cardiac catheterization lab workers (the Healthy Cath Lab Study) Chemical protection against ionizing radiation in subjects undergoing radiodiagnostic procedures: analysis of the role of natural compounds in a translational research plan CIRCULATING ANTI TRANSGLUTAMINASE ANTIBODIES: A NOVEL MARKER OF RECURRENT ABORTION AND A KEY INFLUENCER OF NEO ANGIOGENESIS Circulating Tumour Cells (CTC) and Cancer Stem Cells from human prostate: new device and tools for markers detection,cell isolation and their ex vivo expansion as three dimensional structures GASLINI ORD Genes, Genomes and Genetics Sicilia CLI ORD Cardiovascular and Respiratory Istituto Superiore di Sanita' ORD Risk, Prevention and Health Behavior Molise ORD Cell Biology Lazio ORD Digestive, Kidney and Urological Systems CLINICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT RIZZOLI ORD Musculoskeletal, Oral and Skin Emerging contaminants in the feed food chain: integrated models to support risk analysis Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary Pagina 166 di 332

167 Custom made devices for bone regenerative medicine. RIZZOLI ORD Musculoskeletal, Oral and Skin Exploring hierarchical immunogenicity of mismatched HLA haplotypes for the design of innovative functional matching algorithms in allogeneic transplantation SAN RAFFAELE MONTE TABOR ORD Immunology A perspective study in HIV infected individuals to determine the impact of HAART and the role of specific antiviral immune responses on the establishment and maintenance of virus reservoirs, which are key for chronic virus persistence and disease progress Daily at home follow up of Parkinson s Disease patients motor performance through robotic and portable devices TENDINOPATHY FROM PATHOPHYSIOLOGY TO TREATMENT: HOW TO TARGET REGENERATIVE MEDICINE. SAN GALLICANO ORD AIDS and Related Research SAN RAFFAELE PISANA EST Brain Disorders and RIZZOLI CLI ORD Musculoskeletal, Oral and Skin Papillomavirus (HPV) genital infection in men: genotypes prevalence, presence of viral transcripts and association with genital clinical signs and sperm function Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 13, Study of new factors associated with pathogenicity in V. parahaemolyticus and nono1 nono139 V. cholerae and multilocus sequence typing approach for epidemiological surveillance Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 13, The KidsInPlaces Initiative: an international partnership for the study of societal resilience and early child development Emilia Romagna CLI EST Population 13, and Epidemiology Pagina 167 di 332

168 EARLY EVENTS IN THE INDIRECT PATHWAY IN ANIMAL MODELS OF PARKINSON S DISEASE. Characterization of melanoma cells from primary and metastatic human melanoma in culture: prognostic and therapeutic implications Role of calcineurin/nuclear Factor Activated in T cells (NFAT) activation in leukemogenesis NEUROMED EST Brain Disorders and 13, Emilia Romagna ORD Oncology 1 Basic 13, I. O. V. ORD Oncology 1 Basic 13, Investigating the role of heterochromatin destabilization and Rif1 in the Italian breast cancer population REGINA ELENA ORD Oncology 1 Basic 13, In vivo imaging of microglia signature: from mouse models to brain injured patients MAGGIORE EST Molecular, Cellular, 13, and Developmental Innovative tools to predict the response to chemotherapy in cancer patients SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 13, PLERIXAFOR ADMINISTRATION AND MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS TO PROMOTE NEO VASCULARIZATION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 13, Respiratory Endostatin in chronic urticaria: a mediator involved in the pathogenesis, a tool for the diagnosis and follow up and a potential target for therapy Immunotherapy with CIK Cells for the treatment of mesenchymal tumors: preclinical activity and synergism with targeted therapies Toscana ORD Immunology 13, Piemonte ORD Oncology 2 13, Pagina 168 di 332

169 Assessment and longitudinal monitoring of thymic output and immune status in the 22q11.2 deletion syndrome Biological markers in bone metastases from prostate cancer: evaluation of live and apoptotic Circulating (CTC) and Disseminated tumor cells (DTC) in patients undergoing chemotherapy and correlation with tumor response and bone turnover rate. Patient participation in Change of Shift Procedures. The Implementation of the Bedside handover for the improvement of nursing quality Impact of screening on survival in breast cancer patients: the role of tumor biology Toscana ORD Immunology 13, I. O. V. CLI ORD Oncology 2 13, ARCISPEDALE CLI ORD Healthcare Delivery 13, and Methodologies Toscana ORD Population 13, and Epidemiology Optic nerve and retinal ischemia: the long pentraxin PTX3 as a marker to discriminate vasculitic and non vasculitic causes of sudden blindness SAN RAFFAELE MONTE TABOR CLI ORD Musculoskeletal, 13, Oral and Skin NEW MARKERS FOR THE EVALUATION OF SPERM DNA STATUS IN ONCOLOGICAL PATIENTS. RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY Piemonte ORD Endocrinology, Metabolism, Nutrition and Reproductive 13, MAUGERI ORD Cardiovascular and 13, Respiratory DEVELOPMENT OF AN INTEGRATED STATISTICS AND INFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW MARKER TECHNOLOGIES ISTITUTO TUMORI MILANO EST Oncology 2 13, Pagina 169 di 332

170 ROLE OF MATERNAL INTRAPARTUM ANTITIC PROPHYLAXIS ON NEONATAL GUT MICROTA FLORA AND ONSET OF LATER ALLERGY RELATED DISEASES. Proteomic salivary analysis and a mathematical model for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis. Metabolomic analysis of primary immunodeficiency and its application to a lowcost neonatal screening program. Lombardia CLI ORD Infectious Diseases 13, and Microbiology Toscana ORD Musculoskeletal, 13, Oral and Skin Toscana ORD Immunology 13, Endocannabinoid receptors as potential target for novel therapeutic approaches in the treatment of bladder cancer SAN RAFFAELE MONTE TABOR ORD Oncology 2 13, Glucocorticoid receptor polymorphisms and Corticosteroid Binding Globulin polymorphisms may modulate the clinical effects of immunosuppressive therapy with corticosteroids in determining the risk of developing diabetes after kidney transplantation. Marche CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 13, Evaluation of chemotherapy induced liver damage in patients with colorectal liver metastasis using of non invasive tools REGINA ELENA CLI EST Digestive, Kidney 13, and Urological Systems Optimization, on the basis of Monte Carlo dosimetry, of the therapeutical effectiveness and toxicity of Peptide Radio Receptor Therapies in patients with neuroendocrine tumours THE ROLE OF ALCOHOL USE IN PATIENTS WITH A FIRST EPILEPTIC SEIZURE IN DIFFERENT POPULATIONS. Sicilia CLI ORD Oncology 2 13, Piemonte CLI ORD Population 13, and Epidemiology Pagina 170 di 332

171 MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA Long term effects of chronic metal ion exposure in patients with orthopaedic implants: biochemical and molecular investigation PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) Restoring synaptic degeneration and memory through manipulations of caspase 3/calcineurin activity in mice modelling Alzheimer Disease. SURVIVE: ChemokineS as new therapeutic drugs for cell Viability and functional recovery in brain ischemia. Antiplatelet aspirin therapy and megakaryocytic gene expression: molecular and cellular mechanisms underlying "drug resistance" in preventing cardiovascular events. Unlocking tumor immune recognition through self HLA E molecules Metal ions levels in symptomatic and asymptomatic patients with metal on metal replacement Improvement of ALS patients communication by means of a Brain Computer Interface system based on ERP single trial detection Liguria ORD Oncology 1 Basic 13, RIZZOLI ORD Risk, Prevention 13, and Health Behavior Istituto Superiore di Sanita' CLI ORD Biobehavioral and 13, Behavioral Processes SANTA LUCIA ORD Molecular, Cellular, 13, and Developmental SAN RAFFAELE PISANA ORD Molecular, Cellular, 13, and Developmental Istituto Superiore di Sanita' ORD Vascular and 13, Hematology REGINA ELENA EST Immunology 13, Lombardia CLI ORD Risk, Prevention 13, and Health Behavior S.CAMILLO CLI ORD Emerging Technologies and Training in s 13, Pagina 171 di 332

172 EVALUATION OF EFFICACY AND SAFETY OF FLAVOCOXID, A CATECHIN AND BAICALIN FLAVONOIDS ASSOCIATION, IN THE MANAGEMENT OF METABOLIC SYNDROME: A PRECLINICAL AND CLINICAL STUDY DEFINING THE PATHOLOGICAL IMPLICATIONS OF IGF I AND/OR DHT ABUSE IN HEALTHY SUBJECTS Integration of high throughput and analytical data to discover biomarkers of cell products quality and therapy efficacy in dendritic cells based cancer immunotherapy studies Priority setting in healthcare: the case of home care program in Tuscany Region for heart failure patients Targeting protein to develop novel antiparasitic drugs: the Giardia model Vg9Vd2 T cells in combination with zoledronate as novel immunotherapeutic approach for human neuroblastoma Comparative efficiency and risk assessment of grafting human gabaergic neural precursors from different sources in experimental models of Huntington disease. Adult Niemann Pick type C disease as a model of tauopathy. Implications for the pathogenesis of Alzheimer disease. GENETIC AND NEUROLOGICAL INFLUENCES ON RISK TAKING PROPENSITY Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 13, SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive 13, Istituto Superiore di Sanita' EST Oncology 2 13, Toscana CLI ORD Healthcare Delivery 13, and Methodologies Istituto Superiore di Sanita' ORD Infectious Diseases 13, and Microbiology GASLINI ORD Oncology 2 13, SAN MATTEO ORD Brain Disorders and 13, CARLO BESTA ORD Brain Disorders and 13, Istituto Superiore di Sanita' ORD Population 13, and Epidemiology Pagina 172 di 332

173 Role of the mitogen activated protein kinase ERK5 in chronic liver injury and hepatocellular carcinoma Toscana ORD Digestive, Kidney 13, and Urological Systems Prediction of cognitive impairment in Parkinson s disease: genetic, biochemical and functional neuroimaging study CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 13, Physiological and Pathological contribute of L cysteine/hydrogen sulphide pathway in controlling the function of rat and human bladder Exposure assessment and early effect evaluation in subjects exposed to incidental nanoparticles during working activities in the mechanical engineering factory The UbcH10 therapeutic selection value in the tyrosine kinase inhibitor therapy for the NSCLC THE EFFECTIVENESS OF STRUCTURED PSYCHOEDUCATION FOR RELAPSE PREVENTION IN BIPOLAR DISORDERS A translational study to identify and validate predictive molecular and cytogenetic biomarkers of durable complete response to trastuzumabcontaining chemotherapy for HER2 positive metastatic or locally advanced breast cancer Pathogenesis of idiopathic thromboembolism: role of anti endothelial auto antibodies and endothelial cell dysfunctions. The role of Integrin alpha5/beta1 as a potential therapeutic target in bone metastasis: a translational study NEUROLESI ORD Digestive, Kidney 13, and Urological Systems Lazio ORD Bioengineering 13, and Technologies CROB ORD Oncology 2 13, FATEBENEFRATELLI CLI ORD Biobehavioral and 13, Behavioral Processes HUMANITAS ORD Oncology 2 13, HUMANITAS ORD Immunology 13, I. O. V. ORD Oncology 2 13, Pagina 173 di 332

174 ANTIOXIDANT TREATMENT TO PREVENT MEDICAL HAZARDS OF CYCLIC VARIATIONS OF SOLAR ACTIVITY Integration of expression profiles and genetic mapping data to identify risk variants in IgA nephropathy Multidisciplinary study of the motor function in obese subjects with Prader Willi syndrome: from molecular control to muscular performance. SAN DONATO COF Endocrinology, Metabolism, Nutrition and Reproductive 13, Puglia EST Digestive, Kidney 13, and Urological Systems AUXOLOGICO CLI ORD Musculoskeletal, 13, Oral and Skin Health Technology assessment on mesenchymal stem cells and growth factors in orthopedics and traumatology Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 13, and Methodologies The Pathogenic Role of Trem 2 in Inflammatory Bowel Disease: Implication for Novel Therapeutic Analysis of the clinical heterogeneity on a wide cohort of Rett patient through a biochemical and molecular approach HUMANITAS ORD Digestive, Kidney 13, and Urological Systems AUXOLOGICO ORD Genes, Genomes 13, and Genetics Exploiting the crosstalk between epithelial cells and dendritic cells as a cause of the HIV 1 induced immune dysregulation in the gut. SAN RAFFAELE MONTE TABOR ORD AIDS and Related 13, Research Alteration of B cell compartment in acute and chronic HIV 1 infected individuals: implication for vaccinations Salivary lipidomic and oxidative profile in response to dietary intervention for the oral cancer risk reduction. Lombardia ORD AIDS and Related 13, Research Marche ORD Oncology 2 13, Pagina 174 di 332

175 Human bone cage for lumbar spine interbody fusion: biomechanical evaluation. Functional, ultrastructural and molecular changes in skeletal muscle in chronic heart failure: new insights for a therapy against cardiac cachexia Metabolic syndrome and liver cancer: surveillance program on large population in Veneto Study of a method of calculation of the optimum radionuclide activity in radioimmunotherapy of tumors based on the reduction of the target mass Diurnal and Inter visit IOP fluctuations: a risk factor for conversion from ocular hypertension to primary open angle glaucoma? GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) Plasmonic nanostructures and microfluidic devices: light concentration and manipulation towards quantitative biosensing Pharmacoepidemiology, pharmacosurveillance and identification of predictive factors of oxaliplatin neurotoxicity in colorectal cancer: development and validation of a prognostic score Emilia Romagna ORD Bioengineering 13, and Technologies SAN RAFFAELE PISANA ORD Musculoskeletal, 13, Oral and Skin Veneto CLI ORD Risk, Prevention 13, and Health Behavior Veneto ORD Oncology 2 13, FATEBENEFRATELLI CLI ORD Risk, Prevention 13, and Health Behavior SAN MATTEO CLI ORD Genes, Genomes 13, and Genetics Calabria ORD Bioengineering 13, and Technologies Toscana ORD Oncology 2 13, Spinal Cord Modular Organization in Recovery and Back to Work Management of Neurological Patients. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Integrative, Functional, and Cognitive 13, Inhibition of cathepsin B as a potential therapeutic strategy for human melanoma: in vitro and in vivo investigations Istituto Superiore di Sanita' ORD Oncology 1 Basic 13, Pagina 175 di 332

176 Analysis of immune reconstitution following a new protocol of haploidentical bone marrow transplantation with low incidence of infections Identification and validation of co morbidity scores and analysis of their impact on the fitness for treatment in patients with solid and haematological tumours HUMANITAS ORD Immunology 13, HUMANITAS CLI ORD Healthcare Delivery 13, and Methodologies Animal breeding and functional food to improve human health. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 13, Study of the implication of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC 1a) and adipose triglygeride lipase (ATGL) in Parkinson s disease PTPRJ and EGFR as targets for innovative molecular therapies of lung cancer SAN RAFFAELE PISANA ORD Molecular, Cellular, 13, and Developmental Calabria ORD Oncology 2 13, Pathogenic mechanisms and animal models of hereditary neurodegenerative cerebellar diseases due to mitochondrial defects. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Genes, Genomes 13, and Genetics The genetic basis of mental retardation: modeling Williams Beuren syndrome through somatic cell reprogramming Predictive value of early PET/CT with 18FDG PET on standard dimensional tumor assessment in patients with advanced/metastatic cancer receiving treatment with target based agents. I.E.O. ORD Brain Disorders and 13, PASCALE CLI ORD Oncology 2 13, Pagina 176 di 332

177 impact of accurate patient specific threedimensional treatment planning in molecular radiotherapy Identification and characterization of new SHOXrelated and SHOX unrelated mutations by Next Generation Sequencing analysis and pharmacogenomics evaluation of rhgh treatment Fertility preservation in young Oncological female patients Early risk indicators and prevention of dementia following stroke. Dietary patterns in midlife and occurrence of Alzheimer disease in old ages A novel approach to hand motor, language and interaction rehabilitation in autism spectrum disorders. Evaluation of Neuroprotection with NGF Mimetic Compounds Using Molecular Microimaging of Apoptotic Post ischemic Neuronal Death Long term Legionella control in hospital hotwater distribution systems by water treatment with natural terpenoid based products: assessment of their antimicrobial and toxicological activities in batch, pilot plant and real scale conditions. ARCISPEDALE EST Oncology 2 13, Emilia Romagna CLI ORD Genes, Genomes 13, and Genetics REGINA ELENA CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 13, S.CAMILLO CLI EST Brain Disorders and 13, Lombardia CLI ORD Population 13, and Epidemiology MEDEA CLI ORD Biobehavioral and 13, Behavioral Processes Toscana ORD Brain Disorders and 13, Istituto Superiore di Sanita' CLI ORD Infectious Diseases 13, and Microbiology Pagina 177 di 332

178 The neurobiology of social behaviour: physiological and pathological processes in mice and humans Istituto Superiore di Sanita' EST Biobehavioral and 13, Behavioral Processes Mitochondrial dysfunction in ALS : a study of novel molecular partners as targets for therapeutic interventions Emilia Romagna ORD Molecular, Cellular, 13, and Developmental Policystic ovary syndrome and nitric oxide. Effects of the treatment with N acetylcysteine Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Understanding and treating impairment in automatic movements execution in Parkinson's disease IRCCS AOU San Martino IST (Genova) CLI EST Integrative, Functional, and Cognitive High detection of chronic kidney disease (CKD) in general population by combination of estimated glomerular filtration rate (GFR) and microalbuminuria Puglia CLI ORD Digestive, Kidney and Urological Systems Advance care planning for continuous sedation Toscana CLI ORD Oncology until death in the Hospice setting. What is its role? Sensitizing cancer stem cells driven glioma to radiotherapy via pharmacological inhibition of Ataxia Telangiectasia Mutated protein IRCCS AOU San Martino IST (Genova) ORD Oncology Non invasive cerebral PET data quantification with aortic image derived input function governance and occupational well being: a new organizational approach to healthcare performance Toscana CLI ORD Healthcare Delivery and Methodologies Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Pagina 178 di 332

179 HIV patient s adherence: a study of predictive factors VENOUS THROMBOEMBOLISM IN FAMILIES WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE CLINICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY INVESTIGATION OF INDIVIDUALS WITH INHERITED THROM Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and costbenefit analysis. soluble EGFR in the biotherapeutical approach of colorectal cancer Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats NIR Laser Therapy in pediatric hematooncological patients with oral mucositis induced by chemotherapy: evaluation of clinical efficacy and correlation with modifications of oral microbiota and immunogenic properties of pathogenic microrganisms. Lombardia CLI ORD AIDS and Related Research Lazio CLI ORD Population and Epidemiology Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive ARCISPEDALE ORD Oncology STELLA MARIS CLI ORD Brain Disorders and Toscana CLI ORD Infectious Diseases and Microbiology BiS trial: randomized controlled trial on biologic vs synthetic mesh for the treatment of large defect congenital diaphragmatic hernia. OSPEDALE BAMBINO GESU' CLI ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 179 di 332

180 The molecular interaction between dystroglycan and glycosyltransferases and how it is related to the clinical severity of primary and secondary dystroglycanopathies OSPEDALE BAMBINO GESU' ORD Musculoskeletal, Oral and Skin CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG FIVE IMPORTANT ACUTE HOSPITALS CHARACTERIZATION OF NEW MOLECULAR MARKERS OF NEUROINFLAMMATION ASSOCIATED WITH ALZHEIMER'S DISEASE Stem and progenitor cell therapy for the treatment and prevention of bronchopulmonary dysplasia in preterm infants: pre clinical in vitro studies Studies on the cardiovascular effects of mandibular stretching and on their potential application in the treatment of arterial hypertension RELEASE OF MICRO VESICLES DURING MYOGENIC DIFFERENTIATION PROCESS Identification of new genes responsible for Albinism phenotype Ovarian serous carcinoma:identification of prognostic and predictive markers and risk assessment. Toscana CLI ORD Risk, Prevention and Health Behavior Sicilia ORD Molecular, Cellular, and Developmental SAN MATTEO ORD Cardiovascular and Respiratory Toscana CLI ORD Cardiovascular and Respiratory S.CAMILLO ORD Cell Biology Lombardia EST Genes, Genomes and Genetics Calabria ORD Oncology 1 Basic Pagina 180 di 332

181 Whole exome sequencing of schizophrenia patients with large Copy Number Variations or Run of Homozigosity and functional study of CSMD3, a gene found deleted in a schizophrenia patient. Whole exome sequencing to identify causative genes in Caudal Regression Syndrome Phenotype characterisation of Arrhythmogenic Right Ventricular Cardiomyopathies (ARVC) caused by mutations of desmosome and nondesmosome genes Effectiveness of multidisciplinary clinical approach and psychological treatment on enhanced recovery after surgery in patients with Inflammatory Bowel Diseases (IBD) Quality assurance and improvement of MRI and PET analysis on imaging biomarkers processed in grid environments through automated machine learning approaches. Identification of specific metabolic pathways and protein networks involved in myocardial and cerebral dysfunction and preservation following resuscitation from cardiac arrest and discovery of new biomarkers predictive of functional outcome. Angiogenesis and cell nutrition in lumbar degenerative disc disease: a numerical and experimental investigation Transciptome of B lymphocytes in Multiple Sclerosis. FATEBENEFRATELLI ORD Genes, Genomes and Genetics GASLINI CLI ORD Genes, Genomes and Genetics SAN MATTEO CLI ORD Cardiovascular and Respiratory Toscana CLI ORD Risk, Prevention and Health Behavior FATEBENEFRATELLI ORD Healthcare Delivery and Methodologies SAN DONATO ORD Cardiovascular and Respiratory GALEAZZI ORD Bioengineering and Technologies SANTA LUCIA ORD Brain Disorders and Pagina 181 di 332

182 Improving quality of research: a complex intervention trial "Web based national registry of pediatric collections of specimens and health, environmental, lifestyle data intended to research purposes" Isoform selective histone deacetylase inhibitors in experimental models of ALS: molecular and therapeutic effects The effectiveness of music therapy on depression and on Quality of Life in patients with Amyotrophic Lateral Sclerosis and in post Stroke condition. Emilia Romagna CLI ORD Healthcare Delivery and Methodologies MEDEA ORD Genes, Genomes and Genetics Toscana ORD Brain Disorders and MAUGERI CLI ORD Healthcare Delivery and Methodologies Identification of novel targets in thyroid carcinogenesis by sirna based loss of function screening ISTITUTO TUMORI MILANO ORD Oncology 1 Basic Long term efficacy of non pharmacological computer assisted treatment in Alzheimer s Disease and MCI (Mild Cognitive Impairment) patient Randomized Trial Of Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy In Peritoneal Carcinomatosis Arising From Colorectal Cancer A therapeutic approach to Fragile X syndrome based on the pharmacology of Rho GTPases IDENTIFICATION OF NEW GENETIC, PROTEIC AND METABOLIC MARKERS TO DISTINGUISH BENIGN FROM MALIGNANT THYROID CELLS. Lombardia CLI ORD Brain Disorders and ARCISPEDALE CLI ORD Oncology Istituto Superiore di Sanita' ORD Brain Disorders and Toscana ORD Genes, Genomes and Genetics Pagina 182 di 332

183 Investigation of biochemical and molecular mechanisms underlying photoaging process by a lipidomic approach Identification of new genetic determinants of inhibitor development in patients with hemophilia A by exome sequencing SAN GALLICANO ORD Musculoskeletal, Oral and Skin MAGGIORE ORD Genes, Genomes and Genetics Multicenter Randomized Phase III Study Comparing the combination of 5 Fluorouracil plus Folinic Acid, Irinotecan and Oxaliplatin (FOLFIRINOX) versus Gemcitabine as Adjuvant Treatment for Resected Pancreatic Cancer Toscana CLI ORD Oncology Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with difficult diagnosis: Implications for Disease Definition, Diagnosis, and Treatment. ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Population and Epidemiology Integrated management of continuity of care for amyotrophic lateral sclerosis: proposal for a model Lombardia CLI ORD Healthcare Delivery and Methodologies PREGNANCIES IN WOMEN WITH PREVIOUS ADVERSE OBSTETRIC EVENTS AND PREGNANCY RELATED VENOUS THROMBOEMBOLISM : NEW DIAGNOSTIC TOOLS AND IMPROVEMENT OF THERAPEUTHIC STRATEGIES CASA SOLLIEVO SOFFERENZA EST Endocrinology, Metabolism, Nutrition and Reproductive Anaplastic lymphoma kinase (ALK) gene status assessment to improve treatment of pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO CLI ORD Oncology Pagina 183 di 332

184 IDENTIFICATION OF EARLY NEUROCOGNITIVE MARKERS OF DEVELOPMENTAL DYSLEXIA: THE ROLE OF RAPID AUDITORY PROCESSING AND ITS RELATIONSHIP WITH FOLLOWING PHONOLOGICAL DEFICITS Combined molecular and functional studies to identify novel targets for neuroprotection against brain and spinal cord damage: from bench to bedside. PET imaging of TSPO in neurodegenerative diseases and tumors. MicroRNA Signature of Vascular Complications in Type 1 Diabetes Innate immune signaling networks in intestinal epithelial cells and their role in shaping T cell responses in inflammatory bowel diseases Circulating microrna as potential biomarkers of prediabetic and diabetic complications LCAT MODULATION TO TREAT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE Tuberculosis control among immigrants in Italy: a cost effectiveness assessment. Synaptic alteration of mglur signaling underlying SHANK3 mutations in intellectual disability and their rescue by pharmacological therapies MEDEA ORD Brain Disorders and Toscana ORD Brain Disorders and ONCOLOGICO DI BARI CLI ORD Surgical, Biomedical Imaging, and Bioengineering Piemonte ORD Cardiovascular and Respiratory Istituto Superiore di Sanita' ORD Immunology Veneto ORD Cardiovascular and Respiratory Lombardia EST Vascular and Hematology Piemonte CLI EST Infectious Diseases and Microbiology CARLO BESTA EST Molecular, Cellular, and Developmental Pagina 184 di 332

185 Development of cytochrome c assay marker of ischemia/reperfusion damage to the heart PREDICTION OF AWAKENING FROM ACUTE COMA USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS AND PAIN RELATED FUNCTIONAL BRAIN MAGNETIC RESONANCE. CLINICAL AND MOLECULAR ANALYSIS OF IPEX LIKE SYNDROMES: FOXP3 gene INDEPENDENT DEFECTS OF PERIPHERAL TOLERANCE. Transposon based Forward Genetic Screen for the Identification of non coding RNAs involved in Colorectal Cancer Metastasis I.E.O. ORD Cardiovascular and Respiratory Veneto CLI ORD Brain Disorders and Toscana ORD Immunology C.R.O. AVIANO ORD Oncology 1 Basic CDKL5 variant of Rett s syndrome: clinical phenotype and effects of mutations on the development of the central nervous system in view of future therapeutic approaches Istituto Scienze Neurologiche ORD Brain Disorders and Enhancing Transparency of Reporting of Systematic Reviews to Improve Health Care Integrating chromatin structure, transcriptional regulation and gene expression as a novel approach to define the role of iron regulatory proteins and to study the effect of immunomodulatory and hypomethylating agents on iron genes in experimental models USE OF NEXT GENERATION SEQUENCING IN CLINICS: EVALUATION OF MODELS OF EARLY OR COMPREHENSIVE DIAGNOSIS IN A REGIONAL ASSET Emilia Romagna ORD Healthcare Delivery and Methodologies Piemonte ORD Oncology 1 Basic Liguria CLI ORD Genes, Genomes and Genetics Pagina 185 di 332

186 Molecular modeling and functional analyses of EGFR for the selection of lung cancer patients eligible for targeted therapy with receptor kinase inhibitors ISTITUTO TUMORI MILANO ORD Oncology Modulation of mir 221 and mir 222 in skeletal muscle cells: impact on muscle physiology and pathology Istituto Superiore di Sanita' ORD Musculoskeletal, Oral and Skin Studies of the pathogenic mechanisms and zoonotic role of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary Homing and fate of adipose derived stem cells in two animal models of stroke Development and progression of breast cancer: when EMT meets stemness AUXOLOGICO ORD Biology of Development and Aging C.R.O. AVIANO ORD Oncology 1 Basic Analysis of the effect of chemotherapeutic treatment on trastuzumab cytotoxic activity ISTITUTO TUMORI MILANO ORD Oncology New biomolecular markers (HJURP, HIF 1 alpha, TG2), to predict response to radiotherapy in patients with carcinoma in situ of the breast. Trans abdominal RObots for Minimally Invasive Surgery (TROMIS) Gender and age related differences in motility and permeability responses in human colon: role of estrogens. Emilia Romagna ORD Oncology Lombardia ORD Surgical, Biomedical Imaging, and Bioengineering DE BELLIS ORD Digestive, Kidney and Urological Systems Pagina 186 di 332

187 Multisensory modulation of body representations as a proxy to reduce phantom limb pain in amputees: behavioural, cognitive and neurophysiological studies. Investigations on the pathophysiological role of pendrin, an ion exchanger expressed in thyroid, innear ear and kidney: novel perspectives for the diagnosis and treatment of patients with pendrinrelated disorders. Molecular determinants of tumour resistance to radio/chemotherapies Monitoring allogeneic Hematopoietic stem cells transplant patients for viral load and CMV drug resistance genotypes The mevalonate (Mev) pathway as a common metabolic target to modulate the susceptibility of Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) tumor cells to chemotherapy, environmental prosurvival signals, and immune recognition by Vgamma9Vde Aberrant expression and/or function of the Calcium Sensing Receptor (CaSR) as mechanisms underlying ovarian cancer SANTA LUCIA ORD Integrative, Functional, and Cognitive AUXOLOGICO ORD Genes, Genomes and Genetics Veneto EST Oncology GASLINI ORD Infectious Diseases and Microbiology Piemonte ORD Oncology ONCOLOGICO DI BARI ORD Oncology 1 Basic Post Transplant Hematopoiesis: a model to understand the mechanisms of hematopoietic stem cells (HSC) aging and the interactions between HSC and micro environment. IRCCS AOU San Martino IST (Genova) ORD Vascular and Hematology Promoting neuroplasticity for the symptomatic treatment of patients with Multiple Sclerosis SANTA LUCIA ORD Brain Disorders and Pagina 187 di 332

188 How to improve and rationalize targeted head and neck squamous cell carcinoma treatments ISTITUTO TUMORI MILANO ORD Oncology Personalising curative treatment decision for locally advanced head and neck cancer through identification of biological markers ISTITUTO TUMORI MILANO ORD Oncology Integrated approach to investigate the effect of environmental pollution on reproductive outcomes AN ALTERNATIVE APPROACH TO CLINICAL MANAGEMENT OF GESTATIONAL DIABETES Evaluation of AIFA monitored antineoplastic drugs in advanced cancer patients in the last months of life in Regione Emilia Romagna Brain complexity and complexity matching for enhancing the positive effects of environmental enrichment on psychopathology Emilia Romagna ORD Genes, Genomes and Genetics Lombardia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Istituto Superiore di Sanita' CLI ORD Integrative, Functional, and Cognitive Glia immune crosstalk in multiple sclerosis SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, and Developmental Analysis of immunological reconstitution after intrabone cord blood transplantation for hematological malignancies OSPEDALE BAMBINO GESU' ORD Immunology Autism Epilepsy: endophenotypic characterization and correlation with astrocyteneuron interaction defects. STELLA MARIS ORD Biobehavioral and Behavioral Processes Pagina 188 di 332

189 Opportunistic virus infections in transplant recipients and patients with chronic inflammatory diseases treated with biological immunosuppressive drugs SAN MATTEO ORD Immunology Identification of slow proliferating cancer cells with stem like features Genetic and epigenetic mechanisms in addiction: An opportunity for development of new pharmacotherapeutic strategies for alcoholism. Early detection of brain metastases: in vivo advanced MRI markers in breast and lung cancer patients. New treatments for alleviation of neuropathy and regenerative impairment in diabetes. Istituto Superiore di Sanita' EST Oncology 1 Basic FATEBENEFRATELLI ORD Brain Disorders and SAN RAFFAELE PISANA CLI ORD Brain Disorders and MULTIMEDICA ORD Cardiovascular and Respiratory Vaccine platform for oncogenic viruses. PASCALE EST Immunology Development of bispecific antibodies for therapeutic approaches against HIV infection. Hormonal implications in the mesothelioma pathogenesis. Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health Antiprotons vs photons: a new hypothesis for radiotherapy Istituto Superiore di Sanita' ORD AIDS and Related Research REGINA ELENA EST Oncology 1 Basic Istituto Superiore di Sanita' ORD Oncology ONCOLOGICO DI BARI ORD Oncology Pagina 189 di 332

190 STUDIES OF NEOPLASTIC PREVALENCE IN SINATHROPUS ANIMALS LIVING ON NATIONAL INTEREST SITES(SIN)IN CAMPANIA REGION AND EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENTAL ONCOLOGICAL RISKS Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary Genetic analysis of TPH2 in patients with Major Depression as a predictor of SSRI responsiveness. Role of glucocorticoid induced leucine zipper (GILZ) in autoimmunity NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA. Dissection of the interplay between Ku70/86 and APAF1 as a novel regulatory mechanism in brain tumours The interplay between glutamatergic intracellular pathways and dopamine neurotransmission: relevance for novel antipsychotic strategies and in antipsychotic refractory conditions. FATEBENEFRATELLI ORD Brain Disorders and Istituto Superiore di Sanita' ORD Immunology NEUROLESI ORD Molecular, Cellular, and Developmental SANTA LUCIA ORD Cell Biology PASCALE ORD Emerging Technologies and Training in s Role of endocannabinoids in multiple sclerosis SANTA LUCIA ORD Brain Disorders and Mechanisms of altered DNA methylation in sporadic and hereditary colorectal cancer REGINA ELENA EST Genes, Genomes and Genetics Innovative therapeutic approaches against CD49ddriven microenvironmental interactions in chronic lymphocytic leukemia C.R.O. AVIANO EST Oncology 1 Basic Pagina 190 di 332

191 New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis THERapeutically relevant STEM cells for THALassemia (THERSTEMTHAL) Using hyperbaric hyperoxigenated transportable machine to preserve liver to be transplanted.a new preservation method evaluated throught an animal model transplantation study. Long term cancer survivors: a comparison between treatments and disease free persons and persons with active disease under therapeutic control. Response Evaluation Criteria in Solid Tumors: a comparative study between Imaging and Biomolecular indices Fighting Alzheimer: new prospectives and therapeutical strategies Epigenetic profiles of prognostic markers and therapeutic targets in non small cell lung cancer Complex Interventions at Work: comparative analysis of case studies on implementation of process oriented organization of hospital care in community and teaching hospitals Enpowering neuromodulation by individually tuned brain behavior frequency RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering Emilia Romagna EST Genes, Genomes and Genetics Emilia Romagna EST Surgical, Biomedical Imaging, and Bioengineering C.R.O. AVIANO CLI ORD Oncology Sicilia CLI ORD Oncology SANTA LUCIA EST Brain Disorders and Emilia Romagna ORD Oncology 1 Basic 14, Emilia Romagna CLI ORD Healthcare Delivery 14, and Methodologies Istituto Superiore di Sanita' EST Emerging Technologies and Training in s 14, Pagina 191 di 332

192 Gio why not? A perspective observational study to improve early diagnosis of andrologic pathologies in young people. SAN RAFFAELE MONTE TABOR CLI ORD Risk, Prevention 14, and Health Behavior Characterization of bone marrow endothelial cells in patients with chronic myeloproliferative diseases: towards anti angiogenic therapy CROB ORD Oncology 1 Basic 14, Molecular characterization of the Apical Membrane Antigen 1 from Italian strains of Babesia bigemina and study of its role in the protective host immune response. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 14, HYPOPLASTIC LEFT HEART SYNDROME (HLHS): FROM DISCOVERY OF GENETIC BASIS TO MOLECULAR CLASSIFICATION FOR THERAPEUTIC STRATEGIES Pancreatic Islet Cell Transplantation for Treatment of Type 1 Diabetes Electroclinical and genetic characterization of Epilepsy in a population of patients with ring 20 chromosome syndrome. EEG fmri study and comparison with a group of patients with frontal lobe epilepsies (genetic and structural etiologies) Improving surgical treatment of traumatic nerve injuries by artificial nerve guides: a benefit for the patient and the community HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy. Lombardia ORD Genes, Genomes 14, and Genetics ONCOLOGICO DI BARI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14, Lombardia CLI ORD Brain Disorders and 14, Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14, Lombardia CLI ORD AIDS and Related 14, Research Pagina 192 di 332

193 Identification of new molecular targets in preclinical models of cholangiocarcinoma and in tumor derived xenopatients What is better for the therapy of chronic inflammatory demyelinating polyneuropathy? Intravenous Immunoglobulins versus steroids and intravenous immunoglobulins versus sub cutaneous immunoglobulins: a nationwide costutility study. Effect of telemedicine on Haemophilia Management, Treatment Effectiveness and Patient's Quality of Life Individual and social effects of a sensitisation campaign on headache Piemonte ORD Oncology 2 14, Piemonte CLI ORD Brain Disorders and 14, Abruzzo CLI COF Healthcare Delivery 14, and Methodologies Lazio CLI ORD Healthcare Delivery 14, and Methodologies UNMET NEEDS, QUALITY OF LIFE AND FAMILY BURDEN AMONG ICHTHYOSIS PATIENTS ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Healthcare Delivery 14, and Methodologies Developing new sensitive and objective outcome measures in muscle disorders: the promising role of muscle fat fraction and mapping. Involvement of mutant p53 gain of function in tumor microenvironment NEUROLESI CLI ORD Musculoskeletal, 14, Oral and Skin REGINA ELENA ORD Oncology 1 Basic 14, Identification of predictive markers of response to Therapeutic Plasma Exchange in Multiple Sclerosis Lazio ORD Vascular and 14, Hematology Influence of metabolic factors on inflammation of colorectal mucosa in colorectal cancer risk assessment Emilia Romagna ORD Oncology 2 14, Pagina 193 di 332

194 Role of home pulse oxymetry in management of patients with idiopathic pulmonary fibrosis: a prospective, multicenter study Emilia Romagna CLI ORD Cardiovascular and 14, Respiratory Heart failure specialist nurse services (HFSN) Marche CLI ORD Healthcare Delivery 14, and Methodologies THERAPEUTIC DEVICE OF AREA FOR ADOLESCENCE WITH SEVERE PSYCHIATRIC DISORDERS. PROSPECTIVE STUDY ON EFFICACY. Aortic dimensions and properties in normal population and hypertensive patients: focus on thoracic aortic dilatation The anatomical substrate of unilateral neglect subtypes A NEW STRATEGY FOR A HIGH PREVALENCE CONDITION: ORTHOSTATIC HYPOTENSION. WHAT S UP IN REHABILITATION SETTING? Neurobiological bases of the Impulse Control Disorders: the role of the cerebellum. Lombardia CLI ORD Risk, Prevention 14, and Health Behavior Piemonte CLI ORD Cardiovascular and 14, Respiratory S.CAMILLO ORD Brain Disorders and 14, MAUGERI CLI ORD Risk, Prevention 14, and Health Behavior SANTA LUCIA CLI EST Brain Disorders and 14, Molecular screening and identification of the causative role of Protocadherin 19 (PCDH19) gene (Xq22) gene in a spectrum of epilepsy phenotypes and genotype phenotype correlation. OSPEDALE BAMBINO GESU' ORD Genes, Genomes 14, and Genetics Peri operative stress in cardiac surgery: psychosocial aspects, genetic predisposition and biohumoral characterization Toscana CLI ORD Cardiovascular and 14, Respiratory Pagina 194 di 332

195 Development of optical diagnostic tools for inflammatory bowel diseases based on Raman light scattering. BURLO GAROFALO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14, DEVELOPMENT OF A METHOD FOR NON INVASIVE ROUTINE PRENATAL DIAGNOSIS OF MONOGENIC DISORDERS USING CELL FREE DNA IN MATERNAL PLASMA Veneto ORD Genes, Genomes 14, and Genetics Ring annuloplasty versus Suture repair for the treatment of Not Severe Tricuspid Regurgitation in patients undergoing surgery for Mitral Valve disease: a Prospective, Randomized Study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14, Multi(bio)marker characterization of COPD in the elderly: diagnostic, clinical and prognostic implications Physical exercise and cognitive stimulation: an innovative strategy to contrasting dementia. Epidemiology of primary biliary cirrhosis in Lombardia: a validation and geographical clustering study PREDICTIVE FACTORS IN NSCLC TREATMENT WITH GEFITINIB: ROLE OF TUMOR MICROENVIRONMENT Sensorimotor Integration. Physiology and Pathophysiology SANTA LUCIA ORD Cardiovascular and 14, Respiratory Piemonte CLI ORD Risk, Prevention 14, and Health Behavior HUMANITAS CLI ORD Population 14, and Epidemiology ONCOLOGICO DI BARI ORD Oncology 2 14, MAUGERI ORD Integrative, Functional, and Cognitive 14, Pagina 195 di 332

196 NEW THERAPEUTIC MODALITIES FOR GRAVES ORBITOPATHY WITH THE ANTI CD20 MONOCOLONAL ANTIBODY RITUXIMAB Lombardia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14, GENETIC MODULATION OF COELIAC DISEASE CASA SOLLIEVO SOFFERENZA ORD Digestive, Kidney 14, and Urological Systems The role of anti C terminal ADAMTS13 antibodies in acquired thrombotic thrombocytopenic purpura MAGGIORE ORD Vascular and 14, Hematology Sleepiness related accident risk in sleep disorders with excessive daytime sleepiness: from driving simulator performance to real road accident risk. Istituto Scienze Neurologiche ORD Emerging Technologies and Training in s 14, Novel assays for the diagnosis of scleroderma Marche ORD Immunology 14, Characterization of HIV related mechanisms involved in the development of Burkitt s lymphoma Studying Down Syndrome allows to early diagnose Alzheimer s disease Emilia Romagna ORD AIDS and Related 14, Research SANTA LUCIA CLI ORD Brain Disorders and 14, The effect of moderate aerobic activity (fitwalking) on the metabolic and cardiovascular complications induced by antiretroviral therapy in patients with HIV infection SAN RAFFAELE MONTE TABOR CLI ORD AIDS and Related 14, Research Evaluation of neuroendocrine derangements after severe acquired brain injuries: influence on clinical progression and functional recovery during rehabilitation Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14, Pagina 196 di 332

197 An integrated pharmacogenetic approach to the optimization of adjuvant hormonal treatment of estrogen receptor positive breast cancer Application of new PET tracers for early imaging of radiation induced lung fibrosis in a mouse model Toscana ORD Oncology 2 14, Toscana ORD Oncology 2 14, Identification and functional characterization of genes associated with metastatic risk in uveal melanomas with monosomy of chromosome 3 using integrated genomics IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 14, MZN, a new natural herbal compound to combat HIV infection SAN RAFFAELE MONTE TABOR ORD AIDS and Related 14, Research Evaluation and modulation of behavioral and neurophysiological markers of alcohol misuse S.CAMILLO ORD Brain Disorders and 14, Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular indicators for clinical/disease staging and vaccine efficacy Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 14, Metabolic syndrome in the etiology and prognosis of hepatocellular carcinoma: a multicentre study. THE DOMOTIC GERIATRICS UNIT (DOMO_GER): AN INTELLIGENT SENSOR NETWORK FOR THE PREVENTION OF NEGATIVE OUTCOMES (DELIRIUM, FALLS, SUDDEN DEATH) IN HOSPITALIZED OLDER PATIENTS. EARLY ENVIRONMENTAL RISK FACTORS AND THE RISK OF DEVELOPING ANOREXIA NERVOSA PASCALE CLI ORD Oncology 2 14, Veneto ORD Bioengineering 14, and Technologies FATEBENEFRATELLI CLI EST Brain Disorders and 14, Pagina 197 di 332

198 New radiotherapic technologies(t): role of hypofractionated(h) Intensity Modulated Image Guided Radiotherapy in Locally Advanced Non Small Cell Lung cancer (Stage IIIA IIIB) Myocardial Toll like receptors in human myocarditis. DEVELOPMENT OF A MULTIFUNCTION PLATFORM FOR TELEREHABILITATION Titanium based third generation biomimetic scaffolds for bone tissue regeneration Effect of chemotherapy on ovarian reserve oocytes and role of p63 Emilia Romagna CLI ORD Oncology 2 14, SAN RAFFAELE PISANA CLI EST Cardiovascular and 14, Respiratory S.CAMILLO CLI ORD Healthcare Delivery 14, and Methodologies SAN MATTEO ORD Musculoskeletal, 14, Oral and Skin Lazio ORD Endocrinology, Metabolism, Nutrition and Reproductive 14, Effect of Human C Peptide on the Prevention of Diabetic Retinopathy and Nephropathy in a Rat Model of Type 2 Diabetes SAN RAFFAELE MONTE TABOR EST Endocrinology, Metabolism, Nutrition and Reproductive 14, Role of Notch in regulation of mesenchymal cells from adipose tissue of heart failure patients: consequences for cell therapy Possibility to calculate the 131I activity based on the desired thyroid mass reduction in the radionuclide therapy of Graves' disease MAUGERI EST Cardiovascular and 14, Respiratory Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14, Pagina 198 di 332

199 Risk benefit assessment of cardiovascular drug use in elderly and very old patients affected by cardiovascular disease: a multicentre pharmacoepidemiological study Tailoring electrical parameters of subthalamic nucleus stimulation to treat behavioural symptoms in Parkinson s disease Biomolecular Markers Involved in the Development of Hepatitis Virus Infections Associated Lymphomas: A Multicentric Case Control Study Proximal vs distal approach in the upper limb rehabilitation in sub acute patients using robotic platforms: effects on the motor performance and functional recovery. ROLE OF INFLAMMATION/IMMUNITY IN ATHEROSCLEROSIS: ANALYSIS OF POTENTIAL NOVEL MORPHOLOGIC AND/OR CHEMICAL MARKERS OF PLAQUE PROGRESSION/STABILIZATION Multidisciplinary identification of prognostic markers and therapeutic intervention in patients with epilepsy and psychiatric disorders comorbidity. A translational study. Genome Remodeling in Luminal B and Ductal Triple Negative Breast Cancer Metastasis and Xenograft: Exome sequencing analysis for identification of driver pathways to overcome resistance Lazio CLI ORD Healthcare Delivery 14, and Methodologies MAGGIORE CLI EST Brain Disorders and 14, C.R.O. AVIANO ORD Oncology 2 14, SAN RAFFAELE PISANA CLI ORD Brain Disorders and 14, SAN RAFFAELE PISANA ORD Vascular and 14, Hematology OASI MARIA S.S. ORD Brain Disorders and 14, I.E.O. ORD Oncology 2 14, Pagina 199 di 332

200 Interactive mapping of pathways and targets in renal cancers ISTITUTO TUMORI MILANO CLI ORD Oncology 2 14, The redox basis of opioid tolerance: from molecular mechanism to innovative therapeutic approach for chronic pain management SAN RAFFAELE PISANA ORD Integrative, Functional, and Cognitive 14, µ BiG: Micro Bioreactor platform for the generation and dynamic control of concentration Gradients SAN RAFFAELE MONTE TABOR ORD Bioengineering 14, and Technologies POTENTIAL ROLE OF INFLAMMASOME AS INTRACELLULAR MEDIATOR OF INFLAMMATORY MANIFESTATIONS IN GAUCHER DISEASE (GD) Integrating ehealth technologies for Patient and General Practitioner Empowerment The role of CLIC1 (Chloride channel 1) in the tumorigenicity of glioblastoma cancer stem cells Advanced personal and environmental teledosimetry system PROGNOSTIC, PREDICTIVE AND THERAPEUTIC IMPLICATIONS OF THE DNA "METHYLOME" IN HUMAN CUTANEOUS MELANOMA GASLINI ORD Immunology 14, Lazio CLI ORD Healthcare Delivery 14, and Methodologies I.E.O. ORD Oncology 1 Basic 14, Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 14, C.R.O. AVIANO CLI ORD Oncology 2 14, Breast Cancer targeting through innovative drug delivery systems. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 14, Pagina 200 di 332

201 Building an implantable engineered trachea using amniotic stem cells GASLINI ORD Surgical, Biomedical Imaging, and Bioengineering 14, Genotype Phenotype correlation in familial melanoma patients and multiple primary melanoma patients: Analysis of clinical, histologic, dermoscopic and reflectance confocal microscopy features of melanomas and melanocytic nevi associated with MC1R variants SAN GALLICANO ORD Oncology 2 14, ADIPOSE DERIVED STEM CELLS FOR TENDON REPAIR: THE INFLUENCE OF HYPOXIA ON CELL CULTURES Wilson disease: methionine metabolism and epigenetic regulation of gene expression Preclinical studies on TM9SF4, a novel potential biomarker associated with malignancy in patients with skin cancers Comparative analysis of molecular alterations in circulating tumor cells, primary tumors and metastatic lesions in NSCLC: predictivity of response to targeted therapy A multidisciplinary approach to study Frontotemporal lobar degeneration Wnt/b catenin signaling in melanoma: in vitro and in vivo investigations RIZZOLI ORD Musculoskeletal, 14, Oral and Skin Veneto EST Genes, Genomes 14, and Genetics Istituto Superiore di Sanita' EST Oncology 1 Basic 14, Emilia Romagna ORD Oncology 2 14, FATEBENEFRATELLI ORD Genes, Genomes 14, and Genetics SAN GALLICANO EST Oncology 1 Basic 14, Branched peptides as novel tumor targeting agents Toscana ORD Oncology 2 14, Pagina 201 di 332

202 Autoantibodies specific to ATP synthase in the pathogenesis of Alzheimer disease Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention of Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Nd:YAG laser ablation for mininvasive endoscopic treatment of pancreatic neoplastic lesions: from animal model to human application SAN RAFFAELE PISANA EST Brain Disorders and 14, Emilia Romagna ORD Oncology 2 14, Lazio ORD Surgical, Biomedical Imaging, and Bioengineering 14, Growth and oncolytic properties of Influenza A viruses in human pancreatic tumour cells and animal models Istituto Zooprofilattico Sperimentale delle Venezie ORD Infectious Diseases 14, and Microbiology Oncolytic HSV vector strategy for the study of TRIM8 role in the pathogenesis of glioblastoma and therapy. CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 14, From sarcoma genetics and genomics to novel diagnostic and therapeutic strategies: a deep sequencing approach Brain Computer Interface for rehabilitation in stroke and partial spinal cord injury Functional BRAIN CHIP INTEGRATOR (fbci): A pilot study to implement novel rehabilitation strategies through neurochips technology in patients with disorders of consciousness. Innovative Therapies for memory impairment in Alzheimer's Disease C.R.O. AVIANO ORD Oncology 1 Basic 14, FATEBENEFRATELLI ORD Emerging Technologies and Training in s 14, CARLO BESTA CLI ORD Brain Disorders and 14, FATEBENEFRATELLI ORD Brain Disorders and 14, Pagina 202 di 332

203 Exploring the role of the HIV integrase inhibitor Raltegravir as a treatment of Secondary Progressive Multiple Sclerosis. Istituto Superiore di Sanita' ORD Brain Disorders and 14, Immunological biomarkers predictive of successful direct acting antiviral (DAA) therapy in chronic hepatitis C virus (HCV) infection SAN MATTEO ORD Infectious Diseases 14, and Microbiology Identification of novel biomarkers for Renal Cell Carcinoma early diagnosis by peptidome and exosome analysis Fast tuning of the immune response across the blood brain barrier by drug repurposing in a preclinical setting for translation into stroke therapy Neuropsychological, neuropshysiological and neuroimaging markers of progression in prodromal Alzheimer disease (AD): an interdisciplinary approach to the early detection of AD patients Puglia ORD Oncology 2 14, SANTA LUCIA CLI ORD Brain Disorders and 14, SAN RAFFAELE PISANA CLI ORD Biology of 14, Development and Aging Nerve Growth Factor as a topical treatment for chronic Graft versus Host Disease with ocular involvement: preclinical and randomized, double masked, controlled Phase II study SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 14, Effects of Antidepressant Drugs on Autophagy pathway in neurons Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus MONDINO EST Brain Disorders and 14, Veneto CLI ORD Population 14, and Epidemiology Host biomarkers in exhalate breath condensate and other accessible body fluids for clinical and incipient tuberculosis detection SAN RAFFAELE MONTE TABOR EST Infectious Diseases 14, and Microbiology Pagina 203 di 332

204 Use of antisense oligonucleotides to PTPN22 gene variant conjugated to immuno liposomes as a novel therapeutic approach in type 1 diabetes and autoimmune polyendocrine syndrome type 3 variant OSPEDALE BAMBINO GESU' CLI EST Immunology 14, Mother delivered infant massage in preterm infants to promote neurodevelopment and bonding: effects on infant sleep and brain maturation Molecular epidemiology, Immunoproteomic and host parasite interaction of Echinococcus granulosus complex DEVELOPMENT OF VALIDATED INSTRUMENTS TO ASSESS SPINAL CORD INJURY (SCI) SUBJECTS. Mathematical modelling of mosquito borne diseases in Italy Surveillance of the circulation of rotaviruses in the infantile population of Sicily in view of the introduction of rotavirus vaccination. Mechanisms and treatment of Alzheimer disease: what can we learn from epilepsy? POST TRANSCRIPTIONAL REGULATION AND MITOCHONDRIAL LOCALIZATION OF BRCA1 IN HUMAN BREAST CANCER NEUROREHABILITATIVE PROGRAM FOR LIMB APRAXIA BY NEUROMODULATION OF LINGUISTIC VICARIOUS SKILLS STELLA MARIS CLI EST Brain Disorders and 14, Istituto Superiore di Sanita' ORD Infectious Diseases 14, and Microbiology SANTA LUCIA CLI EST Brain Disorders and 14, Istituto Superiore di Sanita' ORD Population 14, and Epidemiology Sicilia ORD Infectious Diseases 14, and Microbiology SAN RAFFAELE PISANA ORD Brain Disorders and 14, ONCOLOGICO DI BARI ORD Oncology 1 Basic 14, FATEBENEFRATELLI EST Integrative, Functional, and Cognitive 14, Pagina 204 di 332

205 Study of the interactions between noise and vibration exposure in view of the assessment of synergistic effect on the cochlea Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro EST Risk, Prevention 14, and Health Behavior CT scan evaluation of vertebral body derotation in adolescent idiopathic scoliosis surgery Nerve ultrasound examination. The definition of the anatomical damage in nerve diseases: over a functional evaluation to design a diagnostictherapeutic flow chart for patients with neurotraumatic lesions. Randomized Controlled Trial of Ultrasound enhanced thrombolysis in acute anterior circulation stroke RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering Lazio CLI ORD Brain Disorders and ARCISPEDALE CLI ORD Brain Disorders and IPER EXPRESSION OF INSULIN RECEPTOR IN BREAST CANCER: ROLE OF THE TRANSCRIPTION FACTORS AP 2α AND p53 Calabria ORD Oncology 1 Basic Early detection of anthracycline induced cardiotoxicity (ACT) with Tissue Doppler Imaging Echocardiography in pediatric patients carrying SNPs predictive of ACT Sarcopenic obesity in hospitalized older persons: prevalence, associations with the geriatric syndrome of frailty, and effect on clinically relevant adverse health outcomes Use of Tranexamic acid in elective orthopaedic prosthetic surgery for preventing blood loss. Emilia Romagna ORD Oncology Emilia Romagna CLI ORD Biology of Development and Aging Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 205 di 332

206 Incidence of Human Papillomavirus Infection in a North East Italian Population of Patients with Oropharyngeal Squamous Cell Cancer Treated with Intensity Modulated Radiation Therapy and Correlation with Treatment Outcome and Survival Veneto CLI ORD Oncology The challenge of risk stratification in cardiac surgery: the ACEF PLUS to catch extreme conditions SAN DONATO CLI ORD Risk, Prevention and Health Behavior Comparison between patient centered versus standard psoriasis outpatients facilities for management of mild psoriasis patients ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Healthcare Delivery and Methodologies COMPLEMENTARY AND ALTERNATIVE MEDICINE FOR THE TREATMENT OF CHRONIC PAIN: A PILOT STUDY Prevalence of risk factors for cardiovascular and non viral hepatic diseases: an epidemiological study in two Italian populations Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. ROLE OF COLECALCIPHEROL IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT. Immunohistochemical and mirna analysis of tumoral neoangiogenesis in small liver lesions: diagnostic and prognostic value of old and new markers. NEUROLESI CLI ORD Biobehavioral and Behavioral Processes Istituto Superiore di Sanita' ORD Population and Epidemiology Sicilia ORD Risk, Prevention and Health Behavior Piemonte CLI ORD Brain Disorders and Emilia Romagna CLI ORD Oncology Pagina 206 di 332

207 Personalized and optimized Road Map of effective integration between intensive medical treatment and secondary liver surgery in liver limited metastatic colorectal cancer (MCRC) through biomolecular characterization. THYMIDYLATE SYNTHASE AND MAMMALIAN TARGET OF RAPAMYCIN PATHWAYS IN MALIGNANT PLEURAL MESOTHELIOMA: FROM MOLECULAR PREDICTORS OF RESPONSE TO CHEMOTHERAPY TO NOVEL MULTIMODAL THERAPEUTIC STRATEGY. Abruzzo ORD Oncology Piemonte CLI ORD Oncology Effects of metformin on glucose consumption in normal and in cancer cells in vitro and in vivo Potential interference with 18 fluoro deoxyglucose uptake in positron emission tomograpghy IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic Plasma factors, integrins and modulators of podocyte shape. A new window on focal segmental glomerulosclerosis and its treatment Telemonitoring in long term ventilator dependent patients: a multicenter randomized controlled study PROJECT BRIDGE: integrated plan for hospitals and local areas of long term case management for patients with acute cerebrovascular event, stratifed according to their frailty risk. GASLINI EST Digestive, Kidney and Urological Systems Toscana CLI ORD Cardiovascular and Respiratory Emilia Romagna CLI ORD Healthcare Delivery and Methodologies The welfare of the heavy pigs: critical points and practical solutions Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary STUDY OF MDR1 REGULATION MECHANISMS TO REVERSE DRUG RESISTANCE IN OSTEOGENIC SARCOMA RIZZOLI ORD Oncology 1 Basic Pagina 207 di 332

208 SELECTION OF CARDIAC RESYNCHRONIZATION THERAPY CANDIDATES ACCORDING TO SIMULTANEOUS DETERMINATION OF MECHANICAL DYSSYNCHRONY, SITE OF LATEST ACTIVATION AND MYOCARDIAL SCAR Emilia Romagna ORD Cardiovascular and Respiratory Controlled yeast for delivery of therapeutic agents to the human gut. implementation of Adaptive Radiotherapy (ART) head and neck cancer. Evaluation of ART IMRT potential in reducing xerostomia and dysphagia. NEUROLESI ORD Digestive, Kidney and Urological Systems I. O. V. CLI ORD Oncology The use of a numerical model of the cardiovascular system to personalize and optimize cardiac resynchronization therapy (CRT) Lazio ORD Cardiovascular and Respiratory EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF ERYTHRODERMIC CUTANEOUS T CELL LYMPHOMA: CLINICAL ACTIVITY, TOXICITIES, QUALITY OF LIFE IMPROVEMENT AND RESPONSE ASSOCIATED LOGICAL MARKERS Early onset anorexia nervosa: the role of hyperactivity as predictor of outcome Relationship between biomarkers, diastolic left ventricular recoil reserve measurement and ventricular arterial coupling to improve diagnosis and risk stratification in diastolic heart failure. Bio Molecular markers in the secondary prevention, diagnosis, prognosis and personalized therapy of hepatocellular carcinoma. Piemonte CLI ORD Oncology STELLA MARIS CLI ORD Risk, Prevention and Health Behavior Umbria CLI ORD Cardiovascular and Respiratory Veneto ORD Oncology Pagina 208 di 332

209 Long term immune monitoring of patients with psoriasis or psoriatic arthritis treated with drugs targeting key mediators of the immune response to identify key parameters of therapeutic efficacy and/or disease progression Role profiles and clinical competencies: a new approach for healthcare workforce Gaining new insights into the molecular mechanisms underlying the cholangiocarcinoma How to evaluate Efficacy In the framework of costeffectiveness analysis for Growth Hormone (rhgh) Therapy in paediatric patients with Growth Hormone deficiency Identification of biomarkers for an early diagnosis of periprosthetic osteolysis Evaluation of the role of CD 133+/CD44+ colorectal TICs in patterns of metastatization and possible subsequent their clinical investigation Calcium handling proteins common gene variants for the prediction of life threatening arrhythmias in ICD recipients with heart failure SAN GALLICANO ORD Immunology Emilia Romagna CLI ORD Healthcare Delivery and Methodologies REGINA ELENA EST Genes, Genomes and Genetics Piemonte CLI ORD Healthcare Delivery and Methodologies Piemonte ORD Musculoskeletal, Oral and Skin ONCOLOGICO DI BARI ORD Oncology NEUROMED COF Cardiovascular and Respiratory Impaired VitaminD metabolism in Rheumatoid Arthritis. Implication for disease pathogenesis and treatment. Piemonte CLI EST Musculoskeletal, Oral and Skin Diffusion Weighted Imaging (DWI) for the detection and monitoring of pulmonary inflammation: preliminary assessment and validation with molecular imaging. Veneto EST Surgical, Biomedical Imaging, and Bioengineering Pagina 209 di 332

210 C Choline PET/CT as Image Guide for radiotherapic treatment of prostate cancer recurrent lymphnodes SAN RAFFAELE MONTE TABOR CLI ORD Oncology DIALECTICAL BEHAVIOR THERAPY (DBT) VS. HIGH QUALITY OUTPATIENT CARE FOR BORDERLINE PERSONALITY DISORDER. A PRAGMATIC RANDOMIZED TRIAL. Dissecting molecular bases of methylmalonic acidemia by proteomic analysis Emilia Romagna CLI EST Biobehavioral and Behavioral Processes SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive Novel approaches to Chronic Lymphocytic Leukaemia treatment by targeting stromasupported malignant B cell survival, leukaemiaassociated angiogenesis and redox state IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic Transcranial Direct Current Stimulation as treatment in depressive illness: mechanism of action and efficacy Horizontal Epidemiology for Neurological Disorders Evaluation of heart toxicity induced by radiotherapy and chemotherapy for breast cancer Isolation and characterization of mesenchymal stem cells: therapeutic implications for cardiac disease MAGGIORE CLI EST Brain Disorders and CARLO BESTA CLI ORD Population and Epidemiology Toscana CLI ORD Oncology Emilia Romagna ORD Cardiovascular and Respiratory Pagina 210 di 332

211 Abscisic acid, a new endogenous modulator of insulin release and glucose uptake: pre clinical studies of its use to improve the clinical assessment and design novel therapies for diabetes mellitus. IRCCS AOU San Martino IST (Genova) ORD Endocrinology, Metabolism, Nutrition and Reproductive Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in tumor cells: breast cancer targeting and biodistribution Identification of novel genes involved in hereditary colorectal polyposis Neuropsychological, immunogenetic and functional profiles in neurodevelopmental disorders The role of internal models in locomotor schemas and neurorehabilitation of children with cerebral palsy Lombardia ORD Bioengineering and Technologies Emilia Romagna ORD Digestive, Kidney and Urological Systems DON GNOCCHI ORD Integrative, Functional, and Cognitive SANTA LUCIA EST Brain Disorders and Role of FOXP3 in breast cancer metastatic process and possible therapeutic targeting ISTITUTO TUMORI MILANO EST Oncology 1 Basic The role of the immunoregulatory enzymes IDO1 and IDO2 in leukemia development from myelodysplasia: a target for leukemia specific therapy. Emilia Romagna ORD Immunology Role of Calpains in Melanoma Cell Biology Toscana ORD Oncology 1 Basic Sagittal balance in degenerative pathologies: analysis of the radiological, biomechanical and biological aspects involved in the standing position of the spine, pelvis and limbs. HUMANITAS ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 211 di 332

212 Cerebrospinal fluid and serum biomarkers of brain damage in epilepsy Longitudinal, comprehensive, integrated study of outcome in patients with prolonged disorders of consciousness (DOC) NEUROLESI CLI EST Brain Disorders and MAUGERI CLI ORD Brain Disorders and p63 dependent RNA regulatory network in human p63 associated syndromes and cancer IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic Ensuring the safety of human stem cells: evaluation of genomic stability and metrological assessment of regenerative medicine products Study of the interaction between polyomavirus JC (JCV) and stem cells Piemonte ORD Genes, Genomes and Genetics Toscana ORD Infectious Diseases and Microbiology Role of oncogene induced senescence in thyroid carcinogenesis ISTITUTO TUMORI MILANO ORD Oncology 1 Basic Risk assessment and safety procedures for MRI examination on patients with deep brain stimulators The VERY SHINING (Vessels, Endothelium and Risk in the next Years. Sodium Handling and INtake: INteractions with Genes) Study. Identification of predictive biomarkers of pegifnalpha induced depression and comprehension of the underlying mechanisms Istituto Superiore di Sanita' EST Surgical, Biomedical Imaging, and Bioengineering Veneto CLI EST Cardiovascular and Respiratory FATEBENEFRATELLI EST Brain Disorders and Establishing the early profile of chronic renal allograft dysfunction with functional magnetic resonance and contrast enhanced ultrasound SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 212 di 332

213 Improving visual abilities in low vision patients with noninvasive brain stimulation. LONGITUDINAL CHANGES IN MICROARCHITECTURE AND NEURONAL METABOLISM ASSOCIATED WITH PROPRIOCEPTIVE TRAINING TO AMELIORATE BALANCE IN MULTIPLE SCLEROSIS Ingestible device for the intragastric treatment of Helicobacter pylori infection The impact of the insulin/igf I pathway in bladder cancer invasion and metastasis FATEBENEFRATELLI ORD Emerging Technologies and Training in s REGINA ELENA CLI EST Emerging Technologies and Training in s Toscana ORD Infectious Diseases and Microbiology Calabria EST Oncology 1 Basic Development of new strategies to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, genetic and epigenetic analysis Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise EST Molecular, Cellular, and Developmental A translational approach to hypertrophic cardiomyopathy: new therapeutic targets for a personalized drug therapy Targeted resequencing of genomic regions by next generation sequencing technologies Study of the modifications of hematopoietic stem cells methylation profile after transplantation and their role in influencing transplant biology Toscana ORD Cardiovascular and Respiratory GASLINI ORD Genes, Genomes and Genetics CROB ORD Vascular and Hematology Unraveling the fingerprint of a new subset of human tolerogenic dendritic cells SAN RAFFAELE MONTE TABOR ORD Immunology New perspectives in colorectal cancer for early diagnosis and therapy ONCOLOGICO DI BARI ORD Oncology 1 Basic Pagina 213 di 332

214 Multiple Chronic Conditions Prevalence, Care Management, Implications for Quality, and Health Costs Novel strategies for tackling obesity epidemics by targeting the resting energy expenditure (EE) Creation of a Network for a high level care of patients surviving cardiac arrest in Milan.Implementation of tissue donation after death and development of a non heart beating donation program. Lombardia CLI ORD Healthcare Delivery and Methodologies AUXOLOGICO CLI EST Endocrinology, Metabolism, Nutrition and Reproductive Lombardia CLI ORD Healthcare Delivery and Methodologies Monitoring insect vectors of Leishmania in Sicily based on climatic/environmental observations, and definition of mathematical forecast models that can predict the presence of insect vectors depending on environmental conditions. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary Producing ips cells: a biobank service for translational genetic research Research of biomarkers in peripheral blood and tissue specimens for early diagnosis and prediction of therapy response in patients with colorectal cancer. Liguria ORD Genes, Genomes and Genetics Emilia Romagna ORD Oncology Title: Developing and Evaluation of innovative methods for detecting and trace infective pathogens in foods: molecular correlation with human cases Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary TRANSMISSION OF SPORADIC CREUTZFELDT JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES Istituto Superiore di Sanita' ORD Population and Epidemiology Pagina 214 di 332

215 COMBINED APPROACHES FOR DRUG DISCOVERY IN CONGENITAL CENTRAL HYPOVENTILATION SYNDROME Electro chemotherapy: improvement of local activitythrough new molecule association and tailored voltage delivery Association between Chronic Obstructive Pulmonary Disease and lung cancer: mechanisms of immune regulation GASLINI ORD Molecular, Cellular, and Developmental I. O. V. ORD Oncology Veneto ORD Cardiovascular and Respiratory Shaping the autoimmune response in the gut: the role of intestinal microbiota in immune regulation of Type 1 Diabetes SAN RAFFAELE MONTE TABOR EST Immunology Molecular and genetic investigations of the role of BMP15 oocyte derived growth factor in female fertility AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Development and exploitation of a platform able to produce antibody based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology ISTITUTO TUMORI MILANO ORD Oncology Role of Copy Number Variations in determining the individual susceptibility to essential hypertension NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) AUXOLOGICO ORD Cardiovascular and Respiratory Toscana CLI ORD Cardiovascular and Respiratory Pagina 215 di 332

216 Multimodal optical imaging platform for videorate intraoperative near infrared fluorescence cardiac imaging. Provincia autonoma Trento EST Surgical, Biomedical Imaging, and Bioengineering Identification of mirna based Therapeutical Targets in Gliomas by Integrated Genomic Analyses. CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic Identification of Molecular and Genetic Fingerprints Characterizing T cell Non Hodgkin lymphoma Next generation approaches to identify novel pathophysiological mechanisms of coronary intrastent thrombosis and intra stent restenosis Exploitation of immunogenic tumor cell death for improved dendritic cell based cancer vaccines mirnas as New Potential Diagnostic and Predictive Biomarkers for Venous Thromboembolism in Cancer Patients: a Study MAGGIORE ORD Oncology 1 Basic Toscana ORD Cardiovascular and Respiratory C.R.O. AVIANO EST Oncology Emilia Romagna ORD Vascular and Hematology Development, implementation and evaluation of a population based informational and educational package to improve knowledge on palliative care. A quasi experimental study in the Liguria Region. IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery and Methodologies Molecular mechanisms involved in HIV related atherosclerosis: role of pathogen associated molecular patterns, type I interferons, and HIV replication. Viral respiratory tract infections in infants and young children: the IFNs/CD38/Ectonet axis as possible therapeutic target. MONZINO ORD Vascular and Hematology Istituto Superiore di Sanita' ORD Immunology Pagina 216 di 332

217 ADJUSTING THE ENVIRONMENTAL CONTEXT TO IMPROVE SEROTONINERGIC ANTIDEPRESSANT EFFICACY Identification of a panel of enteric hepatic biomarkers in children with an elevated risk of cardiovascular disease and type 2 diabetes A clinical strategy for cartilage repair and osteoarthritis treatment combining mesenchymal stem cell (MSC) based therapy with intrarticular hyaluronic acid infiltration ARTEMIS (Augmented Realism in Teleconsulting and Education in MinimallyInvasive Surgery) GENERATION OF PRION PROTEIN BASED COMPOUNDS AS NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE strategy for developing rationale combinations of molecularly targeted agents in patients with non Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) Development of a carbon nanotube DNA biosensor for rapid detection of subgingival microbiota involved in periodontal diseases. Danger associated molecular patterns: revealing the molecular signals dictating the communication between dying cells with the immune system Istituto Superiore di Sanita' ORD Biobehavioral and Behavioral Processes Toscana CLI EST Cardiovascular and Respiratory Lazio CLI ORD Biology of Development and Aging Toscana ORD Surgical, Biomedical Imaging, and Bioengineering Lombardia EST Brain Disorders and HUMANITAS ORD Oncology Abruzzo ORD Infectious Diseases and Microbiology Istituto Superiore di Sanita' ORD Oncology Pagina 217 di 332

218 Metabolomics of Multiple Myeloma SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics Exposure to low arsenic concentrations via drinking water and health effects in 91 municipalities of the Lazio region, Italy Lazio ORD Population and Epidemiology Innovative analytical procedures and rapid Istituto Zooprofilattico diagnostic methods for the assessment of hygienicsanitary status of the fishery and mariculture Mezzogiorno Sperimentale del production chains for the presence of emerging organic and inorganic micro pollutants and emerging zoonotic pathoge ORD Veterinary Mechanisms of the antitumor activity of HIV protease inhibitors treatment in HIV negative patients affected by classical Kaposi s sarcoma or cervical intraepithelial neoplasia Istituto Superiore di Sanita' ORD Oncology Pediatric brain tumors: evaluation of microrna signatures in cancer stem cells as disease markers in diagnosis, follow up and targeted therapy monitoring OSPEDALE BAMBINO GESU' ORD Oncology SAFETY AND TOLERABILITY OF SECOND GENERATION ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROACTIVE/PROSPECTIVE PHARMACHOVIGILANCE STUDY Induced pluripotent stem cell (ipsc) technology in the study of human genetic diseases of the hematologic system: modelling and correcting the cellular and genetic defect MEDEA CLI ORD Biobehavioral and Behavioral Processes HUMANITAS EST Immunology Pagina 218 di 332

219 RANDOMIZED CONTROLLED TRIAL OF MULTIDIMENSIONAL STIMULATION THERAPY IN PRODROMAL TO MODERATE STAGES OF ALZHEIMER'S DISEASE: CLINICAL, FUNCTIONAL MRI ASSESSMENT AND COST EFFECTIVENESS ANALYSIS. DON GNOCCHI CLI ORD Brain Disorders and Early detection of lung cancer in asymptomatic high risk population by low dose CT scan and molecular markers. I.E.O. CLI ORD Oncology Identification of new biomarkers in rhabdomyosarcoma: potential targets of novel therapeutic strategies. OSPEDALE BAMBINO GESU' EST Oncology 1 Basic OVERCOMING TARGETED TREATMENT RESISTANCE IN HUMAN CANCER: NOVEL STRATEGIES TO INHIBIT SURVIVAL AND ESCAPE SIGNALS AND TARGETED DELIVERY OF ANTI CANCER NANOPARTICLES Gender specific oncology: psychoncology s contribution to global care and rehabilitation of young adult male and female patients Early signs and early treatment in Rett syndrome: a functional, imaging and molecular study in young patients and in MeCP2 null Mice. REGINA ELENA EST Oncology C.R.O. AVIANO CLI ORD Oncology STELLA MARIS ORD Brain Disorders and 15, Genome wide association study (GWAS) to identify new disease causing genes and new susceptibility loci for focal segmental glomerulosclerosis (FSGS) in European population. Puglia ORD Genes, Genomes 15, and Genetics Pagina 219 di 332

220 Biomolecular profiling of cutaneous squamous cell carcinoma and precursor lesions: HPV infection, immune system genes expression and polymorphism, mirna analysis and novel biomarkers investigation SAN GALLICANO ORD Oncology 1 Basic 15, Improving the diagnostic homogeneity in schizophrenia using cognitive endophenotypes: an integrated genetic, neuroimaging and neurocognitive approach SANTA LUCIA CLI EST Brain Disorders and 15, Functional and viability impairment of cardiomyocytes in familial amyloid polyneuropathy Toscana ORD Cardiovascular and 15, Respiratory Genome wide SNP identification for high resolution molecular genotyping of Listeria monocytogenes Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Infectious Diseases 15, and Microbiology PROMOZIONE DELLA SALUTE ORALE NELLE REALTA SCOLASTICHE DELLA ASL MILANO Calcium sensitizer agents for improving organs protection in transplants. Immune mechanisms of Food Protein Induced Enterocolitis Syndrome (FPIES) Pain management in patients with renal failure: conventional and unconventional pain therapy. A long term analysis of efficacy and tolerability of opioids analgesics and acupuncture in ESRD. HIV STDs coinfection in treated MSM patients: measurement of plasmatic and seminal HIV Viral Load Lombardia CLI ORD Healthcare Delivery 15, and Methodologies Piemonte CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15, Toscana ORD Cell Biology 15, Liguria CLI ORD Digestive, Kidney 15, and Urological Systems Lombardia CLI ORD Infectious Diseases 15, and Microbiology Pagina 220 di 332

221 Hormonal changes and impaired spermatogenesis in young males with different levels of spinal cord injury: A longitudinal study Homocysteine serum levels in patients with cutaneous lupus erythematosus: pathogenetic and therapeutic implications. Prevention of recurrence of idiopathic calcium stones and risk of developing associated diseases: a study of salt sensitivity genetics, urinary phenotype risk and body composition. MAUGERI CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 15, Toscana CLI ORD Musculoskeletal, 15, Oral and Skin Emilia Romagna CLI ORD Digestive, Kidney 15, and Urological Systems Interim FDG PET/CT in the assessment of early response to concurrent chemo radiotherapy in patients with non small cell lung cancer stage IIIA IIIB ARCISPEDALE CLI ORD Oncology 2 15, Hepatitis E: break the chain between animals and human Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia CLI ORD Veterinary 15, IL 21 based immunotherapy for disseminated neuroblastoma: a preclinical study IRCCS AOU San Martino IST (Genova) ORD Oncology 2 15, Urinary FDG loss and measurement of standardized uptake value "SUV" IRCCS AOU San Martino IST (Genova) ORD Surgical, Biomedical Imaging, and Bioengineering 15, A rehabilitation tool for motor impairement: action observation S.CAMILLO CLI ORD Biobehavioral and 15, Behavioral Processes Resistin as a biomarker of coronary artery disease, major cardiovascular events and all cause mortality in patients with type 2 diabetes. CASA SOLLIEVO SOFFERENZA ORD Vascular and 15, Hematology Pagina 221 di 332

222 Neuropsychological and imaging characterization of cognitive decline in Parkinson s disease Molecular tools for the diagnosis and treatment of early placentation defects and related pregnancy pathologies Experience dependent molecular and cellular mechanisms of vestibular compensation S.CAMILLO CLI ORD Brain Disorders and 15, BURLO GAROFALO EST Endocrinology, Metabolism, Nutrition and Reproductive 15, Piemonte ORD Molecular, Cellular, 15, and Developmental Genetic polymorphisms in genes of drug related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma. I. O. V. CLI ORD Oncology 2 15, D.A.I.P.P. Assessment of influencing factors in diabetes incidence and progression in paediatric immigrant population Muscle Catabolism Fuels Anabolic Tumor Growth: and Therapeutic Implications Piemonte CLI ORD Healthcare Delivery and Methodologies 15, GASLINI EST Oncology 1 Basic 15, ROLE OF HUMAN PAPILLOMAVIRUS IN THE DEVELOPMENT OF PENILE CANCER IN PATIENTS WITH LICHEN SCLEROSUS: CLINICAL, VIDEODERMATOSCOPIC, HISTOPATHOLOGIC AND MOLECULAR STUDY Sicilia CLI ORD Oncology 1 Basic 15, The pathophysiology of alpha synuclein toxicity and infectivity in Parkinson s disease: molecular mechanisms and therapeutic implications FATEBENEFRATELLI ORD Brain Disorders and 15, Pagina 222 di 332

223 The burden of arterial and venous thromboembolism in the Italian active population: a twenty years long prospective VITA (VIcenza Thrombophilia and Atherosclerosis) COhort STudy (VITA COST) Veneto CLI ORD Vascular and 15, Hematology Novel approaches to the functional characterization of unclassified variants in BRCA genes. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 15, Unravelling new cellular and molecular mechanisms of Myotonic Dystrophy (DM) phenotype through the use of DM derived Induced Pluripotent Stem Cells (ipscs) Role of local synthesis and of systemic administration of Brain Derived Neurotrophic Factor (BDNF) in the striatum of the murine model of Huntington s disease. Carcinogenic potential of Lipofilling (LF) and Adipose Derived Stem Cells (ADSCs) in breast cancer SANTA LUCIA ORD Genes, Genomes 15, and Genetics SANTA LUCIA ORD Brain Disorders and 15, Sicilia ORD Oncology 1 Basic 15, Analysis of myocardial function after aortic valve replacement with a novel sutureless valve: coupling mathematical models to clinical research. Sicilia CLI ORD Cardiovascular and 15, Respiratory Neurological and visual impairment in Cobalamin C defect: a novel therapeutical approach based on antioxidant therapy OSPEDALE BAMBINO GESU' CLI ORD Brain Disorders and 15, Cancer and Heart study: Cancer from Radiological medical imaging in cardiovascular patients Toscana CLI EST Cardiovascular and 15, Respiratory Pagina 223 di 332

224 Cross Sectional study to evaluate the interactions between gut microflora and immune system at the cross road of the pathogenesis of Inflammatory Bowel Diseases and Irritable Bowel Sydrome Istituto Superiore di Sanita' ORD Infectious Diseases 15, and Microbiology Role of extracellular Tat in HIV infection Istituto Superiore di Sanita' ORD AIDS and Related 15, Research Assessment of the role of image guided radiotherapy (IGRT) in the treatment of head and neck cancers. A randomized phase III study of chemo radiation for stage III IVa oropharynx cancers: IGRT Intensity Modulated Radiotherapy (IMRT) with dose fraction esc ErbB2 blockade induces myocardial dysfunction, countered by PDE5 inhibition, and by enhancement of myocytes Ca2+ cycling and myofilaments Ca2+ sensitivity, and by melusin cardiac overexpression Allergic contact dermatitis to nickel and related alloys Detailed virological characterisation of patients with virological failure receiving integrase inhibitors and/or CCR5 inhibitors: RNA and DNA resistance profile, plasma and cell viral load, V3 loop characterisation and pharmacokinetic profile Targeting mitochondria associated Heat Shock Proteins, autophagy and bioenergetics in human solid tumors Neural response to behavioral treatments in Focal Hand Dystonia ARCISPEDALE CLI ORD Oncology 2 15, PASCALE ORD Cardiovascular and 15, Respiratory SAN GALLICANO ORD Cardiovascular and 15, Respiratory Istituto Superiore di Sanita' ORD AIDS and Related 15, Research MAGGIORE EST Oncology 2 15, Veneto CLI EST Brain Disorders and 15, Pagina 224 di 332

225 Brain heart axis impairment in stroke patients: integration of neuroimaging data with cardiovascular variability signals. Molecular characterization of IFI16 protein: development of new diagnostic and therapeutic tools for autoimmunity Istituto Superiore di Sanita' EST Brain Disorders and 15, Piemonte ORD Immunology 15, Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation of prevention strategies. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 15, EVALUATION OF HUMORAL AND CELLULAR REACTIVITY IN KIDNEY ALLOGRAFT PATIENTS: NEW TOOL TO TRIM THE IMMUNOSUPPRESIVE THERAPY IN ACCORDING TO THE AGE High resolution array CGH study in patients with infancy epileptic encephalopathies of unknown etiology. Neural correlates of apathy and Executive Dysfunction in Parkinson s disease. Piemonte CLI ORD Immunology 15, OASI MARIA S.S. ORD Brain Disorders and 15, NEUROLESI EST Brain Disorders and 15, Persistence and adaptation mechanisms of clinical methicillin resistant Staphylococcus aureus clones SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 15, and Microbiology Role of polymorphisms of genes involved in alloreactive response in kidney transplantation: implications for personalized post transplant therapies Alzheimer's disease and insulin resistance: new biomarkers for early detection Abruzzo ORD Immunology 15, Piemonte CLI ORD Biology of 15, Development and Aging Pagina 225 di 332

226 Rising up brain activity by non invasive brain stimulation to improve cognitive and behavioural abilities in patients with Alzheimer s disease Novel strategies in the pathogenesis, epidemiology and prognostic factors of papillary thyroid cancer FATEBENEFRATELLI ORD Biobehavioral and 15, Behavioral Processes Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 15, Relationship between iron metabolism and proteasome functionality suggests novel therapeutic strategies for Multiple Myeloma SAN RAFFAELE MONTE TABOR ORD Oncology 2 15, UPPER LIMB IMPAIRMENT IN CHARCOT MARIE TOOTH PATIENTS: MOTOR STRATEGIES, IMPACT ON QUALITY OF LIFE AND CORTICAL FUNCTIONAL REORGANIZATION Molecular subtype based follow up program in patients treated for early breast cancer Non invasive assessment of liver steatosis and fibrosis, and lymph nodes diseases in pediatric patients. Development of Training Optimization Techniques for Robot assisted Neurorehabilitation. Effects of an educational intervention for reducing inappropriate prescribing in elderly exposed to polypharmacy in general practice DON GNOCCHI CLI ORD Musculoskeletal, 15, Oral and Skin Emilia Romagna CLI ORD Oncology 2 15, SAN MATTEO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15, MAUGERI EST Brain Disorders and 15, Lombardia CLI ORD Healthcare Delivery 15, and Methodologies Pagina 226 di 332

227 MicroRNAs as potential diagnostic and therapeutic tools for Multiple Osteochondromas disease RIZZOLI EST Musculoskeletal, 15, Oral and Skin POSSIBLE ROLE OF 18F FDG PET/CT IN DEFINING THE APPROPRIATE USE OF PRRT IN PATIENTS WITH METASTATIC GEP NETs WITH EVIDENCE OF TUMOUR PROGRESSION FOLLOWING TREATMENT WITH SOMATOSTATIN ANALOGUES. ISTITUTO TUMORI MILANO CLI ORD Oncology 2 15, Liver Factory SAN MATTEO ORD Surgical, Biomedical Imaging, and Bioengineering 15, ANORECTAL MALFORMATIONS (ARM): A MULTIDISCIPLINARY RESEARCH TO IDENTIFY PREDISPOSING FACTORS AND NEW THERAPEUTICAL APPROACHES Genetic predisposition to severe and recurrent infections: unravelling the pathogenic mechanisms of susceptibility Neurophysiological indices of functional network integration in vegetative and minimally conscious patients and their relation to awareness and prognosis p38 MAP kinase signalling pathway in T cell commitment and senescence in Autoimmunity Food pyramids and nutritional prevention campaigns Veneto ORD Genes, Genomes 15, and Genetics SAN MATTEO CLI ORD Immunology 15, SANTA LUCIA CLI EST Brain Disorders and 15, SANTA LUCIA ORD Immunology 15, CROB ORD Healthcare Delivery 15, and Methodologies Pagina 227 di 332

228 Cognitive and physical trainings to improve the clinical outcome in Alzheimer s disease by modulation of brain plasticity: a clinical and MRI investigation Innovative biomarkers for prevention, diagnosis and prognosis of colorectal cancer Identification of novel genetic alterations and key cellular pathways to be targeted in acute myeloid leukemia. PATOPHISIOLOGY EVALUATION OF THE LUNG WITH MECHANICAL ASSESTMENT PRE AND POST ENDOSCOPIC VOLUMETRIC REDUCTION IN THE TREATMENT OF PATIENTS WITH SEVERE ENFISEMA SANTA LUCIA CLI ORD Brain Disorders and 15, ARCISPEDALE ORD Oncology 2 15, Veneto ORD Oncology 1 Basic 15, Emilia Romagna CLI ORD Cardiovascular and 15, Respiratory High throughput sequencing to reveal the undesired microbiota in raw cheeses Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 15, Imaging and molecular analysis of brain inflammation in depression: a translational approach SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 15, Development and preclinical testing of novel adenosine 2A receptor antagonists for the treatment of Parkinson s disease and clinical implementation of potential adenosine receptorrelated biomarkers Air pollution, Epigenomic Arterial Signatures, and Post Heart Surgery Risk of Cardiovascular Events MONDINO ORD Brain Disorders and 15, MAGGIORE EST Genes, Genomes 15, and Genetics Pagina 228 di 332

229 Na+ Ca2+ exchanger 1 (NCX1) as new potential therapeutic target in the management of bacteriainduced heart hypertrophy and related complications A multidisciplinary approach to personalized medicine in CRC The Salivary Proteomics biomarkers for Alzheimer's disease study (SaP AD study) Marche ORD Cardiovascular and 15, Respiratory Sicilia CLI ORD Oncology 2 15, Sicilia ORD Brain Disorders and 15, Calcific arteriopathy in chronic kidney disease: genetic determinants, molecular biology and clinical markers SAN RAFFAELE MONTE TABOR ORD Biology of 15, Development and Aging Development of an easily available Monte Carlo based tool to improve dose delivery accuracy in helical tomotherapy DESIGN AND TEST OF A SPECIFIC CUSTOM ARRAY CGH FOR GENOME WIDE COPY NUMBER VARIATIONS (CNVs) AND NEXT GENERATION SEQUENCING OF CANDIDATE GENES IN HYPERTROPHIC CARDIOMYOPATHY Development of tailored treatments targeting biologic hallmarks in chronic lymphocytic leukemia (CLL) Global and gene specific DNA methylation in maternal infant pairs, environmental exposures, and subsequent respiratory and neurobehavioral phenotypes in childhood Istituto Superiore di Sanita' ORD Oncology 2 15, Liguria ORD Genes, Genomes 15, and Genetics Piemonte ORD Oncology 1 Basic 15, Lazio EST Genes, Genomes 15, and Genetics Pagina 229 di 332

230 FACES IV: A DIAGNOSTIC INSTRUMENT TO EVALUATE FAMILY FUNCTIONING IN A SAMPLE OF PATIENTS IN THE PEDIATRIC AGE OSPEDALE BAMBINO GESU' CLI ORD Biobehavioral and 15, Behavioral Processes ELBA.PSDEcological Language Behaviour Assessment For Post Stroke Dementia Mice models of osteosarcoma and hemangiosarcoma development. Early molecular and immunological mechanisms involved in tumor onset and malignancy as targets of innovative therapies. Molecular profiling of malignant tumors of the nose and paranasal sinuses: evaluation of diagnostic, prognostic and therapeutic implications Early non invasive molecular diagnosis of prostate cancer:role of cell free DNA in blood and urine S.CAMILLO CLI EST Biobehavioral and 15, Behavioral Processes RIZZOLI ORD Oncology 1 Basic 15, Toscana ORD Oncology 1 Basic 15, Emilia Romagna ORD Oncology 1 Basic 15, Regulation of mtor functions by Che 1 REGINA ELENA ORD Oncology 1 Basic 15, Oxidative stress induced DNA damage response and autophagy in skeletal muscle cells: mechanisms and implication for muscle dystrophy SANTA LUCIA EST Biology of 15, Development and Aging Lower limb robotic exoskeleton for children with motor impairment OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 15, Oral and Skin PROBING THE ROLE OF ION CHANNELS IN NEUROPATHIC PAIN CARLO BESTA ORD Molecular, Cellular, 15, and Developmental Pagina 230 di 332

231 INNOVATIVE TREATMENTS FOR NEUROGENETIC DISEASES AND THEIR COMPLICATIONS: ATAXIA TELANGIECTASIA Ventricular tachyarrhythmias associated with cardiac hypertrophy and myocardial infarction: implications for early recognition of micrornas levels and treatment Biomolecular characterization of new histone deacetylase inhibitors in uveal melanomas Extraneuronal airway cholinergic system and ß2ARs function in stable COPD and control subjects Analysis of causative genes in patients with Frontotemporal Lobar Degeneration and study of genotype phenotype correlations. Lazio CLI ORD Genes, Genomes 15, and Genetics Calabria ORD Cardiovascular and Respiratory Sicilia ORD Oncology Emilia Romagna ORD Cardiovascular and Respiratory Toscana ORD Genes, Genomes and Genetics Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients with Medullary Thyroid Cancer PASCALE CLI ORD Oncology Translation of in vitro and in vivo ascorbate research into a new loco regional treatment option for colo rectal cancer liver metastases not eligible for surgical resection: Phase I/II Trial Sicilia CLI ORD Oncology Development of pre operative investigation tools and surgical procedures for the treatment of movement disorders in childhood OSPEDALE BAMBINO GESU' COF Brain Disorders and management of viral infections in pediatric hematopoietic stem cell transplant recipients. Piemonte CLI ORD Infectious Diseases and Microbiology Pagina 231 di 332

232 A randomized controlled, double blind study on the effect of chronic thyroid hormones administration on left ventricular remodellingin patients with heart failure and low T3 syndrome. Stratification of patients with chronic hepatitis C according to IL28B polymorphism and IFNstimulated genes (ISGs) expression: prediction of response to antiviral treatment and selection for individualized therapy schedules. Sicilia CLI ORD Cardiovascular and Respiratory Piemonte CLI ORD Digestive, Kidney and Urological Systems Major Congenital Malformation: Long term Health Related Quality of Life of Patients and their Families OSPEDALE BAMBINO GESU' CLI ORD Healthcare Delivery and Methodologies KNEE rehabilitation after Anterior Cruciate Ligament reconstruction: design, development and METROlogical characterization of computational methods and digital (wireless) data communication protocols for improving therapy effectiveness and medical operat Umbria ORD Surgical, Biomedical Imaging, and Bioengineering Safety profile and prescribing pattern of psychotropic medications in childhood. Fighting intestinal schistosomiasis: novel targets for drugs and diagnostics Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area Sicilia CLI ORD Brain Disorders and Lazio ORD Infectious Diseases and Microbiology DE BELLIS ORD Population and Epidemiology Evaluation of long term health issues of adult women with a Disorder of Sex Development (DSD) attending the first Italian Adult DSD Clinic. Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 232 di 332

233 G protein coupled receptor 35 as a new target in the treatment of neuropathic pain Maternal metabolic hormones impact on human breast during pregnancy. A MULTIDISCIPLINARY EMERGENCY APPROACH TO IMPROVE QUALITY OF CARE AND REDUCE POST TRAUMATIC STRESS DISORDER IN CHILDREN EVALUATION OF PLATELET ACTIVATION BY CYTOFLUORIMETRIC ANALYSIS OF PAC 1 EXPRESSION IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS Molecular profiling of salivary gland cancer: evaluation of diagnostic, prognostic and therapeutic implications The hmena alternative splicing program and host immune response in EMT and breast tumor progression Inflammatory pathways, oxidative stress and ischemia/reperfusion injury in human donor hearts: a comparative analysis between accepted and refused grafts for transplantation ROLE OF ESTROGENS IN HUMAN HEPATOCELLULAR CARCINOMA: POTENTIAL IMPLICATIONS FOR PREVENTION AND TREATMENT Toscana ORD Molecular, Cellular, and Developmental Abruzzo CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Emilia Romagna ORD Vascular and Hematology Toscana ORD Oncology REGINA ELENA EST Oncology 1 Basic Lombardia CLI ORD Cardiovascular and Respiratory Sicilia ORD Oncology 1 Basic Pagina 233 di 332

234 Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development Epidemiology, Biomolecular Characterization, Phylogenetic Analysis, and Evaluation of Urine Testing Strategy for Diagnosis of Chlamydia and HPV Infections in Migrant Women with Limited Access to Health Care Istituto Superiore di Sanita' CLI ORD Population and Epidemiology Lombardia CLI ORD Infectious Diseases and Microbiology Aggressive angiomyxoma: pattern of presentation and molecular expression in a multicenter series ISTITUTO TUMORI MILANO CLI ORD Oncology Cardiac output regulation in artificial hearts MONZINO CLI ORD Cardiovascular and Respiratory Study of SP A polymorphisms as a predictor of over all lung transplant outcome. Rehabilitation in Chronic Disability: Connecting Care 2.0 Harnessing reactive oxygen species to target cancer cells Safety and efficacy of the Drug Eluting Balloon (DEB) vs plain balloon angioplasty for the treatment of the Superficial Femoral Artery (SFA) ischemic vascular disease in symptomatic patients presenting with long lesions: a randomised study. and molecular genetic spectrum of Coenzyme Q10 deficiencies: identifications of new phenotypes and genetic variants. Implications for the pathogenesis and therapeutic approach. SAN MATTEO EST Cardiovascular and Respiratory Lombardia CLI ORD Healthcare Delivery and Methodologies I. O. V. ORD Oncology 1 Basic SAN RAFFAELE PISANA CLI ORD Cardiovascular and Respiratory NEUROLESI CLI EST Genes, Genomes and Genetics Pagina 234 di 332

235 Statistical methods for the detectection of Genomic Copy Number Variants from High Throughput Sequencing data Protein synthesis and atrophy regulation by metabolic modulators. Potential role in the treatment of muscle wasting disorders. Three key drugs in newborns: a novel approach for micro dosingby mean of advanced mass spectrometry techniques "Leading nanomedicine into the therapy for Leukodystrophies: nanoparticles overcoming the blood brain barrier to treat the mouse model of Krabbe Disease" Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. Preventing onset of psychosis in high risk youths: identification and treatment MicroRNA regulation of cellular signalling pathways: Identification of prognostic and therapeutic biomarkers in high risk soft tissue sarcoma patients Bone Morphogenetic Protein pathway induces Cancer Stem Cells differentiation enhancing the chemosensitivity of breast and colorectal cancers to conventional chemotherapy Quitline for smoking cessation in women adhering cervical cancer screening Toscana ORD Genes, Genomes and Genetics SAN RAFFAELE PISANA ORD Biology of Development and Aging Toscana CLI ORD Cardiovascular and Respiratory BURLO GAROFALO ORD Molecular, Cellular, and Developmental MAGGIORE CLI ORD Cardiovascular and Respiratory MONDINO CLI EST Brain Disorders and RIZZOLI ORD Oncology 1 Basic Sicilia ORD Oncology Piemonte CLI ORD Risk, Prevention and Health Behavior Pagina 235 di 332

236 INTERMEDIATE INTENSIVE CARE UNIT (IICU CRITICAL AREA ) In vitro and in vivo models for the functional study of a complicated form of hereditary spastic paraplegia (SPG9). Impact of influenza vaccination in HIV 1 multitreated elderly patients Evaluation of CARDIac function in patients with chronic LIVER disease (CARDIO LIVER) Postmenopausal Women s Bone Health: A Novel Approach to Prevent fragility fracture Prevalence and clinical impact of Chronic Obstructive Pulmonary Disease (COPD) in patients with cardiovascular disease and predictive power of cardiovascular risk factors in patients with COPD Indolent non follicular lymphomas prognostic project (NF2010 study) on behalf of the Italian Lymphoma Foundation (FIL) Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Emilia Romagna ORD Genes, Genomes and Genetics Istituto Superiore di Sanita' EST AIDS and Related Research Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering Calabria CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive SAN RAFFAELE PISANA CLI ORD Cardiovascular and Respiratory SAN MATTEO CLI ORD Oncology New strategies for craniofacial tissue engineering MAUGERI ORD Bioengineering and Technologies Biocompetent dendrons (BD) vs platelet rich plasma (PRP) finalized to induce angiogenesis and bone regeneration in osteonecrosis. Marche EST Musculoskeletal, Oral and Skin Pagina 236 di 332

237 Gene identification in muscle disorders disrupting cell extracellular matrix interactions A health technology life cycle model from emerging to obsolete technologies CARLO BESTA EST Musculoskeletal, Oral and Skin Veneto CLI ORD Healthcare Delivery and Methodologies Ultraviolet solar radiation and aromatic hydrocarbons as carcinogenic factors in outdoor workplaces: exposure quantification and biomarkers identification aimed at the identification of principal effects and possible synergistic effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Population and Epidemiology TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. Cardiotoxicity of anticancer treatments. Biomarkers and diagnostic tools for evaluation of cardiological risk of oncological patients Effect of eyes covering on variations of melatonin secretion, electroencephalographic pattern and outcome in patients with severe neurological damage. Evaluation of the pharmaco/toxicological profile of new smart drugs of abuse and optimization of targeted analytical procedures for their detection in biological samples ONCOLOGICO DI BARI ORD Oncology MULTIMEDICA CLI ORD Cardiovascular and Respiratory Emilia Romagna ORD Brain Disorders and Toscana ORD Risk, Prevention and Health Behavior Modulation of integrin binding selectivity: a computational approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics Pagina 237 di 332

238 Osteosarcoma and vanilloid/cannabinoid system: new disease markers and new therapeutic targets OSPEDALE BAMBINO GESU' ORD Musculoskeletal, Oral and Skin Identification of organs that are reservoir of immunosoppressive cells during tumor development and progression SAN RAFFAELE MONTE TABOR ORD Immunology Neurological and clinical study of Prevalence and Incidence of Dementia in Posttraumatic Stress Disorder patients Insights into oxidative stress induced modification of creatine kinase in human heart failure: epiphenomenon or mechanicistic marker? NEUROLESI ORD Brain Disorders and MONZINO ORD Cardiovascular and Respiratory Pharmacological enhancement of tumor cell death ISTITUTO TUMORI by soluble or membrane bound TRAIL and SMACmimetics MILANO ORD Oncology 1 Basic Large scale exome sequencing in familial and sporadic amyotrophic lateral sclerosis. Innovative combinatorial therapeutic strategies to revert resistance to target therapy in NSCLC Epigenetic determinants of psoriasis and psoriatic arthritis: diagnostic and prognostic values of DNA methylation patterns Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs AUXOLOGICO ORD Brain Disorders and PASCALE EST Oncology Emilia Romagna ORD Musculoskeletal, Oral and Skin Istituto Superiore di Sanita' ORD Digestive, Kidney and Urological Systems FATEBENEFRATELLI ORD Biobehavioral and Behavioral Processes Pagina 238 di 332

239 NeuronHeart Cytoskeletal proteins of neurons confer cardioprotection against myocardial infarction Toscana ORD Cardiovascular and Respiratory Russell Bodies: biophysics and biology of proteostasis in an ER storage disorder. SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics Nanomedicine applied to cerebral ischemia NEUROLESI ORD Brain Disorders and Inhibiting p38alpha in colorectal cancer: moving beyond the Warburg effect Role of nicotinic receptor subtypes in alcoholtobacco dependence DE BELLIS ORD Oncology Emilia Romagna ORD Genes, Genomes and Genetics Human infection from exposure to norovirus: improving diagnostic techniques and correlation analysis between clinical cases and infected food. Developing a network among hospital units and IIZZSS in some Italian regions Istituto Zooprofilattico Sperimentale delle Venezie ORD Infectious Diseases and Microbiology One year follow up of infected fetuses.1) Implementation of clinical pathways for an appropriate/comprehensive care of women infected during pregnancy and of infants with congenital infection.2) Role of innate immunity in the susceptibility to infect OSPEDALE BAMBINO GESU' CLI ORD Infectious Diseases and Microbiology Autoimmunome driven immunotherapy of Alzheimer's Disease Non invasive brain stimulations: EEG reactivity in vegetative and minimal conscious state patients Piemonte EST Brain Disorders and 16, S.CAMILLO CLI ORD Brain Disorders and 16, Pagina 239 di 332

240 and molecular mechanisms of accelerated aging in dialysis patients. Therapeutic heart rate lowering in coronary artery disease patients and endothelial shear stress: the likely beneficial link Familial hyperlipidemias: new diagnostic approaches A new treatment of depression in the elderly: positive memory neurostimulation as an alternative to antidepressants? Prognosis and therapeutic biomarkers of prostate cancer Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (NGS PTL) Abruzzo ORD Biology of 16, Development and Aging MAUGERI ORD Cardiovascular and 16, Respiratory SDN ORD Genes, Genomes 16, and Genetics NEUROLESI CLI ORD Biobehavioral and 16, Behavioral Processes Puglia ORD Oncology 2 16, Emilia Romagna ORD Oncology 2 16, HER2 status and outcome in refractory advanced colorectal cancer (CRC) patients (pts) treated with cetuximab based chemotherapy Emilia Romagna ORD Oncology 2 16, Comparison of next generation sequencing based identification of translocations with copy number alteration based identification of deletions for the development of patient/tumor specific real time PCR assays for detection of minimal residual disease usin IRCCS AOU San Martino IST (Genova) CLI COF Oncology 2 16, Intensive nutritional counseling and quality of life in patients affected by non small cells lung cancer: a randomized controlled trial Lombardia CLI ORD Oncology 2 16, Pagina 240 di 332

241 IDENTIFICATION OF NOVEL LOGICAL AGENTS FOR THE SYSTEMIC TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA: TRAIL MEDIATED APOPTOSIS SENSITIZATION THROUGH REACTIVE OXYGEN SPECIES (ROS) INDUCTION AND INHIBITORS OF APOPTOSIS PROTEIN (IAP) SILENCING. Search for new mutations and polymorphisms of FSHR and LHR genes in hypergonadotropic hypogonadic patients without obvious testicular pathogenic noxa. Evaluation of predictors of nimesulide induced liver injury by analysis of individual genetic susceptibility Detection and management of Thyroid nodules: assessment of a screening program carried out by General Practitioners I. O. V. ORD Oncology 2 16, Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, Sicilia ORD Digestive, Kidney 16, and Urological Systems ARCISPEDALE CLI ORD Healthcare Delivery 16, and Methodologies Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating Patients Satisfaction and Multidisciplinary Team Working ISTITUTO TUMORI MILANO CLI ORD Healthcare Delivery 16, and Methodologies Salivary gland tumours: molecular and molecularcytogenetic studies to identify diagnostic/prognostic markers and risk factors THOROUGH DEFINITION OF HER2 AND CHROMOSOME 17 STATUS IN BREAST AND GASTRIC CANCER: A CRUCIAL STEP TO DELIVER THE RIGHT THERAPY TO THE RIGHT PATIENT Istituto Superiore di Sanita' ORD Genes, Genomes and Genetics 16, Piemonte CLI ORD Genes, Genomes 16, and Genetics Pagina 241 di 332

242 SiPIMIS (Single Portal with Intraperitoneal Magnetic Instruments Surgery): a brand new no scar surgical approach for major abdominal intervention. Incidence of Oropharyngeal/oral cancer and Human Papillomavirus (HPV) in Italy and Prevalence of High Risk HPV in oral exfoliated cells in the general population A molecular approach to identify carotid plaque vulnerability for stroke prevention Lombardia EST Surgical, Biomedical Imaging, and Bioengineering 16, Toscana ORD Population 16, and Epidemiology Emilia Romagna ORD Vascular and 16, Hematology PAIN AND ANALGESIA IN THE PRETERM NEWBORN: A LONGITUDINAL STUDY ON NON PHARMACOLOGIC METHODS EFFICACY AND THEIR INFLUENCE ON PAIN PROCESSING CORTICAL MATURATION BURLO GAROFALO CLI ORD Brain Disorders and 16, Role of mutant p53/polo like kinase 2 axis in tumor progression and in the maintenance of genomic instability in cancer cells REGINA ELENA ORD Cell Biology 16, The role of diet in psoriasis ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Risk, Prevention 16, and Health Behavior EasyHIFU: simplified lesion localization for HIFU treatment Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 16, Interaction between environmental, noninfectious stressors and the type I Interferon system: a pig model of response to mycotoxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Immunology 16, Pagina 242 di 332

243 The proteomic profile of breast cancer: an innovative approach using bottom/up mass spectrometry and MALDI imaging IRCCS AOU San Martino IST (Genova) ORD Oncology 2 16, Correlation between clinical pathological features and gene expression profile in pediatric tumors of glial origin. Development of non invasive multimodal techniques for the diagnosis and characterization of epilepsy Immunopathogenetic mechanisms of idiopathic retroperitoneal fibrosis Liguria ORD Oncology 1 Basic 16, Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 16, Emilia Romagna ORD Immunology 16, High throughput parallel sequencing of Mycobacterium avium subsp. paratuberculosis in sheep, of affected/non affected sheep transcriptome and of environmental samples. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 16, Therapeutic targeting of HSP105 in human non Hodgkin lymphomas ISTITUTO TUMORI MILANO ORD Oncology 2 16, ROLE OF FIBROBLASTS IN THE PATHOGENESIS OF DERMATITIS HERPETIFORMIS AND CELIAC DISEASE MAGGIORE ORD Immunology 16, New predictive markers of response to chemoradiotherapy in rectal cancer: microrna and methylation profile Emilia Romagna ORD Oncology 1 Basic 16, Study of the combined effects of Low Level Laser Therapy (LLLT) and bioactive coating on bone deposition and resorption. MAUGERI ORD Bioengineering 16, and Technologies Pagina 243 di 332

244 MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII ISOLATES BY RAPD AND MLVA ANALYSES Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 16, Validation of MRI and PET markers for cellular and molecular features of human brain tumors: definition of their prognostic and therapeutic value. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 16, Role of Mcl 1 protein in tumor angiogenesis and progression ROLE OF OXIDATIVE AND NITROSATIVE STRESS IN OBESE PREGNANT WOMEN PHARMACOGENETICS OF PEMETREXED AND CARBOPLATIN IN MALIGNANT PLEURAL MESOTHELIOMA (MPM) PATIENTS. Signaling pathways of healthy and unhealthy aging: a life long perspective Study of cerebral glucose metabolism by means of positron emission tomography (PET) in psoriatic patients with and without depression major before and after effective anti psoriatic therapies The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiency on alterations of bone mineral metabolism in young women with chronic bowel diseases: a pilot study. REGINA ELENA EST Oncology 1 Basic 16, Marche ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, HUMANITAS ORD Oncology 2 16, Istituto Superiore di Sanita' ORD Biology of 16, Development and Aging SAN GALLICANO ORD Musculoskeletal, 16, Oral and Skin AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, Pagina 244 di 332

245 Therapeutical approaches for diabetes due to the proteotoxic effect of misfolded insulin and betacellular ER stress OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, A Multi center 3T MR Assessment of T2 Perfusion and T1 Permeability in brain Gliomas: the MAPPING study SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 16, Structure, Function and New Insight Strategies for Prevention of Left Atrium Remodeling In Mouse Heart Failure PGD in genetic alteration and repeated failures in IVF patients Functional, structural and genetic correlates of cognitive and emotional impairments in Mood Disorders. PROTIC TREATMENT TO PREVENT ALLERGEN SENSITIZATION: A PRECLINICAL STUDY IN PREGNANT AND NEWBORN MICE Post translational modification of beta 2 glycoprotein I as candidate to modulate immune and endothelial cells homeostasis: implication in women with preeclampsia Multimodality MR imaging (DTI, fmri and quantitative relaxometry) for the evaluation of cerebral modifications induced by different rehabilitation protocols in children with cerebral palsy and traumatic brain injury. MONZINO EST Cardiovascular and 16, Respiratory Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, FATEBENEFRATELLI ORD Brain Disorders and 16, Istituto Superiore di Sanita' ORD Immunology 16, Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 16, MEDEA CLI EST Brain Disorders and 16, Pagina 245 di 332

246 and experimental investigations of novel disease mechanisms in pain processing and Parkinson Disease CCRL2 as a new therapeutic target in rheumatoid arthritis TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES AND CLINICAL APPROACHES IN GASTRIC CARCINOMA THAT PROVIDE INFORMATIVE CLUES FOR EARLY DIAGNOSIS AND TREATMENT OF GASTRIC CANCER Development of innovative methods for radiobiological optimization of radio nuclide therapy treatments MONDINO ORD Brain Disorders and 16, HUMANITAS ORD Immunology 16, C.R.O. AVIANO ORD Oncology 2 16, REGINA ELENA ORD Oncology 2 16, Development and validation of a set of indicators based on administrative data to monitor longterm care for disabled elderly Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 16, and Methodologies NMDA based pharmacotherapy associated to cue exposure therapy: a potential treatment for nicotine relapse FATEBENEFRATELLI ORD Brain Disorders and 16, Development of an innovative strategy based on the use of lytic bacteriophages for an effective and safe treatment of irrigation and washing waters of crops Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 16, PHENOTYPE VARIABILITY IN PRNP E200K MUTATION CARRIERS: A CLINICAL, GENETIC AND PROTEOMIC STUDY Istituto Superiore di Sanita' EST Genes, Genomes 16, and Genetics Pagina 246 di 332

247 Reshaping attention with rewards cracking the code of attentional biases in addiction Near infrared technology for trafficking the fate of stem cells in vivo: a translational study for longitudinal tracking in a rodent model of Parkinson s disease A Steam Cell based translational approach for early diagnosis and effective treatment of Hepatocellular Carcinoma. FATEBENEFRATELLI CLI ORD Integrative, Functional, and Cognitive 16, AUXOLOGICO ORD Emerging Technologies and Training in s 16, Friuli Venezia Giulia ORD Oncology 2 16, NEW MOLECULAR APPROACHES FOR THE DETECTION OF DIOXINS AND DIOXIN LIKE COMPOUNDS IN EXPOSED SHEEP Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 16, Detection of Mycobaceterium avium subsp. paratuberculosis in human Crohn s disease and in ruminants and possible role of contaminated food Istituto Zooprofilattico Sperimentale del Mezzogiorno CLI ORD Infectious Diseases 16, and Microbiology Drug Compliance in Allogeneic Stem Cell Transplantation (DAST) SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 16, and Methodologies A pharmacogenomic approach for Interferons treatment in multiple sclerosis SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 16, Prognostic role of arterial stiffness and vascular calcifications on peripheral arterial occlusive disease in chronic kidney disease. A multi center, observational, prospective, non invasive study. Assessment and management of risk factors for sleep disordered breathing and sleep bruxism in pediatric populations. The role of Orthodontics. AUXOLOGICO CLI ORD Vascular and 16, Hematology Emilia Romagna CLI EST Integrative, Functional, and Cognitive 16, Pagina 247 di 332

248 Performance of serum SMRP as screening tool (the cancer predictive values of SMRP ) surveilling a cohort of asbestos exposed individuals Liguria CLI ORD Oncology 2 16, Physiopathological mechanisms of freezing of gait in Parkinson disease and development of rehabilitative therapeutic strategies Predictive role of von Willebrand Factor changes in bleeding complication during continuous flow left ventricular assist device support The SHARP Study: Simultaneous Hybrid Revascularization by Carotid Stenting and Coronary Artery Bypass Grafting S.CAMILLO CLI ORD Brain Disorders and 16, Lombardia CLI ORD Vascular and 16, Hematology Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering Biotherapy of Colorectal Carcinoma by enhancing Lazio EST Oncology HLA class II expression and cooperation with CD16+ myeloid cells in the CRC microenvironment FUNCTIONAL EVALUATION OF HIP KNEE AND ANKLE ARTHROPLASTY FOR OSTEOARTHRITIS IN ELDERLY A NEW CARE MODEL TO MAINTAIN FUNCTION IN STROKE PATIENTS:EARLY THERAPEUTIC PATIENT EDUCATION AND LONG TERM GROUP PHYSICAL ACTIVITY(e TEAM2011 : early Therapeutic Education Associated with Movement) DO COC'S HAVE AN EFFECT ON PERITONEAL FLUID CYTOKINES?? RIZZOLI ORD Musculoskeletal, Oral and Skin ARCISPEDALE CLI ORD Risk, Prevention and Health Behavior Emilia Romagna CLI ORD Risk, Prevention and Health Behavior Pagina 248 di 332

249 Gadoxetic acid (Gd EOB DTPA) enhanced magnetic resonance in the diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in cirrhotic patients: identification of diagnostic patterns and correlation with molecular transporters and histopat Protective ventilatory strategy in severe brain injured patients: a randomized control trial Assessment of Olfactory Function in Vegetative and Minimally Conscious State A Mathematical Model to optimize allocation of regional health care resource Frameless localisation technique for brain stereotactic radiotherapy MicroRNA expression profiling as biomarker for cutaneous melanomas Novel targets of cocaine and amphetamine influencing intercellular communication mechanisms Emilia Romagna CLI ORD Oncology Piemonte CLI ORD Cardiovascular and Respiratory NEUROLESI CLI ORD Brain Disorders and NEUROLESI ORD Healthcare Delivery and Methodologies Toscana CLI ORD Oncology Sicilia ORD Oncology 1 Basic S.CAMILLO ORD Brain Disorders and Evaluation of Diagnostic Accuracy of DW and DCE Magnetic Resonance Imaging in the Mesorectal Nodes staging of Rectal Carcinoma ISTITUTO TUMORI MILANO ORD Surgical, Biomedical Imaging, and Bioengineering Linguistic competence screening for dementia in patients with ischemic stroke. S.CAMILLO CLI EST Biobehavioral and Behavioral Processes Pagina 249 di 332

250 Biomarkers of adverse neuropsychological outcomes in pre term newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) and genetics Expression of markers associated with the main degradative pathways in fibroblasts derived from patients with sporadic or genetic Parkinson's disease: a study of susceptibility. Long term impact of an Atrial Fibrillation Unit on the management and on the outcome of patients with atrial fibrillation Development and validation of a simple and wearable new system for monitoring sleep and respiratory variables Abruzzo CLI EST Brain Disorders and MONDINO ORD Molecular, Cellular, and Developmental Liguria CLI ORD Cardiovascular and Respiratory Toscana CLI ORD Bioengineering and Technologies Biochemical effects in ALS rehabilitation patients. S.CAMILLO CLI ORD Musculoskeletal, Oral and Skin Development of novel bisphosphonate entrapping liposomes to target macrophages: application in cancer prevention and therapy Hepatitis C virus (HCV) infection beyond the liver: bone and cardiovascular manifestations. Development of pharmacological strategies for the personalization of anti leukemic therapy for pediatric acute lymphoblastic leukemia Plasticity of facial emotional recognition and behavior in patients with Mobius Syndrome before and after surgical facial reanimation. GASLINI ORD Immunology Sicilia CLI ORD Musculoskeletal, Oral and Skin BURLO GAROFALO CLI ORD Oncology Emilia Romagna ORD Integrative, Functional, and Cognitive Pagina 250 di 332

251 First line chemotherapy with capecitabine vs regime xeloxiri (capecitabine, oxaliplatin and irinotecan) in elderly patients with locally advanced or metastatic cancer of the stomach or gastro esophageal junction: a phase II multicenter, randomized, open New recreational drugs of abuse intoxication: prevalence estimation in the Emergency Departments referring to the Pavia Poison Centre The impact of depressive disorders on endothelial progenitor cells in patients with ischemic heart disease The BRCAness profile: from the molecular basis to the clinical relevance Genetics and molecular biomarkers of Food Allergy Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, Cost Effective Algorithm Guided bone regeneration with innovative degradable scaffolds MAUGERI CLI ORD Risk, Prevention and Health Behavior Toscana ORD Cardiovascular and Respiratory Toscana ORD Oncology 1 Basic Toscana EST Genes, Genomes and Genetics Lombardia CLI ORD Oncology Sicilia CLI ORD Oncology RIZZOLI ORD Musculoskeletal, Oral and Skin Hypertension in the pathogenesis of Leukoaraiosis: the role of Obstructive Sleep Apnea NEUROLESI CLI ORD Brain Disorders and Cancer predictivity of biomarkers of exposure: an occupational based approach HIV 1 Nef protein affects opportunistic infections in human macrophages MAUGERI ORD Oncology 1 Basic Istituto Superiore di Sanita' ORD AIDS and Related Research Pagina 251 di 332

252 Impact Of Different Kras Mutations On Tumour Progression And Drug Sensitivity In Non Small Cell Lung Cancer Development of a miniaturized, automated assay for the diagnosis of rare diseases Biological foundations of self control and potential diagnostic implications Mechanisms of beneficial effects of physical exercise on healthy aging and neurological agerelated diseases Lombardia ORD Oncology Piemonte COF Bioengineering and Technologies Istituto Superiore di Sanita' ORD Biobehavioral and Behavioral Processes MAUGERI ORD Biology of Development and Aging Bioengineering of TAVI Istituto Superiore di Sanita' EST Cardiovascular and Respiratory Oxidative stress in animals cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumours Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary significance and biomolecular characterization of VUS BRCA and analysis of phenotypic characteristics associated to BRCA1 5083del19 and 4843delC BRCA1 founder mutations in Sicilian patients with hereditary breast and ovarian cancer. Sicilia ORD Oncology Engineering the microenvironment of implantable matrices to enhance the host response to tissue damages: a new regenerative medicine approach for wound healing IRCCS AOU San Martino IST (Genova) EST Cell Biology Nutrient Signaling Pathways and Immune Response in the Sensitization of Neuroblastoma and Breast Cancer to Chemotherapy GASLINI EST Oncology Pagina 252 di 332

253 Use and integration of clinical and administrative databanks to evaluate the quality and continuity of care processes for epidemiological study and for health planning for patients affected by heartbrain vascular diseases. Lombardia CLI ORD Healthcare Delivery and Methodologies Effectiveness of cognitive remediation in schizophrenia: a prospective, multicenter study in the "real world" setting of Italian psychiatric services Cancer stem cells as a model of carcinogenesis for head and neck squamous cell carcinoma: new technologies with potential to translate from the laboratory into the clinic. Health information systems to control for confounding in comparative outcome evaluation. Population study of disability health and ageing in Lombardia (DISHAL) The pathophysiological substrates of myoclonic syndromes: implementation of innovative multimodal functional approach and treatments From diet to cancer: an integrated approach to study the complex path from visceral fatassociated inflammation to colon cancer GENERATION OF HUMAN MONOCLONAL ANTIBODIES INTERFERING WITH HIV TRANSCYTOSIS FOR THE PREVENTION OF MUCOSAL INFECTION The Italian National Program on Surveillance of Antiretroviral Treatment in Pregnancy Lombardia CLI ORD Brain Disorders and CROB EST Oncology Lazio CLI ORD Healthcare Delivery and Methodologies CARLO BESTA CLI ORD Population and Epidemiology CARLO BESTA ORD Brain Disorders and Istituto Superiore di Sanita' ORD Immunology Istituto Superiore di Sanita' ORD AIDS and Related Research Istituto Superiore di Sanita' ORD AIDS and Related Research Pagina 253 di 332

254 New prognostic markers and therapies for Merkel cell carcinoma Platelet activation in type 2 diabetic patients with stable Coronary Artery Disease: insights into their thrombotic propensity using a Genome Wide approach. Post genomic approach to heart failure in diabetic patients Glycation/glycoxidation products in the pathogenesis of cardiovascular diseases: a search for new biomarkers of cardiovascular risk Genomic and Proteomic Biomarkers in Patients with Subarachnoid Hemorrhage SAN GALLICANO ORD Oncology MONZINO ORD Vascular and Hematology SAN DONATO CLI ORD Cardiovascular and Respiratory Istituto Superiore di Sanita' ORD Cardiovascular and Respiratory Sicilia EST Brain Disorders and Risk assessment of arsenic exposure from ricebased food in children with celiac disease. Study of urinary metabolic profiles and genetic polymorphisms. OSPEDALE BAMBINO GESU' ORD Veterinary Multimodal MRI in the degenerative brain diseases SANTA LUCIA CLI EST Brain Disorders and Glycated haemoglobin and fasting blood glucose concentration: distribution, time trends and prediction of cardiovascular diseases in the Italian adult population Identification and characterization of "cancer stem cells/tumor initiating cells" in chronic lymphocytic leukemia Istituto Superiore di Sanita' ORD Population and Epidemiology C.R.O. AVIANO ORD Oncology 1 Basic Pagina 254 di 332

255 MULTI CENTER STUDY ON METABOLIC COMPLICATIONS IN HIV INFECTED PEDIATRIC PATIENTS BREAST CANCER RISK AND DIETARY MICRONUTRIENTS ASSOCIATED WITH ONE CARBON METABOLISM PATHWAY IN BRCA1/2 SUBJECTS: AN OBSERVATIONAL STUDY Prediction of patient specific total knee arthroplasty outputs: development of a validated patient specific numerical tool to predict contact mechanics and polyethylene stress Recruitment, computer assisted electroencephalographic analysis and functional evaluation in Encephalopathy with Status Epilepticus during Sleep/Continuous Spike and Waves during Sleep. Lombardia CLI ORD AIDS and Related 17, Research C.R.O. AVIANO ORD Population 17, and Epidemiology GALEAZZI ORD Bioengineering 17, and Technologies MONDINO CLI EST Brain Disorders and 17, Chromogranin A (CgA) in the diagnosis and monitoring of patients with gastro enteropancreatic (GEP) neuroendocrine tumors (NET): a single institution experience. MAGGIORE CLI ORD Oncology 2 17, Development and validation of a new urinary test for the detection of phosphoproteins in bladder cancer (BC) Determination of a therapeutic window of ontreatment platelet reactivity values in patients undergoing percutaneous coronary intervention to optimize both ischemic and bleeding adverse events. REGISTRY FOR HEREDITARY AND FAMILIAL BREAST CANCER AND IDENTIFICATION OF NEW DISEASE CAUSING GENES AND REGIONS Piemonte CLI ORD Oncology 2 17, MAUGERI ORD Cardiovascular and 17, Respiratory Lombardia CLI ORD Oncology 2 17, Pagina 255 di 332

256 The effectiveness of Individual Placement and Support (IPS) in clients with first episode of psychosis. Nanosize imaging with brain amyloid/tau targeted nanoparticles as an in vivo biomarker for Alzheimer s disease pathology High field MR evaluation in low level consciousness patients Effects of ambulatory oxygen on breathlessness, mobility and quality of life in patients with idiopathic pulmonary fibrosis Predicting recidivism of driving under the influence of alcohol and drug. A genetic, neuropsychological and evoked potential study. ReShape: Evaluation of determinants for cardiac remodeling after early mitral valve repair with annuloplasty using new computational tools Emilia Romagna CLI ORD Healthcare Delivery 17, and Methodologies Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 17, NEUROLESI CLI ORD Brain Disorders and 17, Toscana CLI EST Cardiovascular and 17, Respiratory Veneto EST Biobehavioral and 17, Behavioral Processes MONZINO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 17, An epizootiological survey of bats as reservoirs and vectors of emerging zoonotic viruses in Italy: implications for public health and biological conservation Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 17, Andrological Screening and Reproductive Health in Young Adult Males Veneto CLI ORD Population 17, and Epidemiology Identification of prevalence of urinary incontinence in breast cancer women in hormonal treatment. Identification of a diagnostic and therapeutic path. Toscana CLI ORD Healthcare Delivery 17, and Methodologies Pagina 256 di 332

257 Role of the combined ultrasonographic imaging and neurophysiological study for surgical treatment of peripheral nerves pathologies Downmodulation of CCR5 expression on T cells through maraviroc and its anti reservoir properties on a simian AIDS model NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES FOR CONGENITAL DIARRHEAL DISORDERS Sicilia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 17, Istituto Superiore di Sanita' ORD AIDS and Related 17, Research Lazio CLI ORD Digestive, Kidney 17, and Urological Systems ROLE OF ENPP1 AND HSP70 SERUM LEVELS ON CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS CASA SOLLIEVO SOFFERENZA ORD Vascular and 17, Hematology DEVELOPMENT AND VALIDATION OF A NOVEL PROGNOSTIC SCORING SYSTEM FOR MYELOFIBROSIS BASED ON DEEP SEQUENCING MUTATIONAL ANALYSIS Evidence of preclinical Alzheimer s disease in healthy middle aged persons MARKERS OF PROGRESSION, INFLUENCE ON COGNITIVE IMPAIRMENT OCCURRENCE AND OXIDATIVE STRESS IN CAROTID ATHEROSCLEROSIS Transthyretin (TTR) amyloidosis: modulation of amyloidogenesis and neurotoxicity of three TTR variants. Immunological and virological predictors of HCV cure during therapy with the new direct acting antivirals (DAAs) Toscana ORD Oncology 2 17, FATEBENEFRATELLI ORD Brain Disorders and 17, Marche ORD Brain Disorders and 17, AUXOLOGICO ORD Brain Disorders and 17, Istituto Superiore di Sanita' ORD Immunology 17, Pagina 257 di 332

258 CREATION OF A LOGICAL BANK AND SEARCH FOR MARKERS OF DISEASE FROM THE POPULATION BASED REGIONAL REGISTRY OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS IN EMILIA ROMAGNA REGION Emilia Romagna CLI ORD Brain Disorders and 17, STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST UTILITY ANALYSIS SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 17, and Methodologies Healthy diet: evaluation of antioxidant capacity of a weekly selected menu in elderly people, and factors affecting its strength. Fibrin resistance to lysis in pulmonary hypertension Inhibition of adrenal beta arrestin 1 signaling pathway as a new therapeutic target to counteract the adverse effects of heart failure related hyperaldosteronism MOLECULAR DISSECTION OF GENETIC AND CLINICAL VARIABILITY IN PRIMITIVE MYOCARDIAL DISEASES OF CHILDREN AND ADULTS BY BENCH TOP NGS SEQUENCER Emilia Romagna CLI ORD Healthcare Delivery and Methodologies 17, Toscana ORD Cardiovascular and 17, Respiratory MAUGERI ORD Cardiovascular and Respiratory 17, Lombardia ORD Cardiovascular and 17, Respiratory HUNT FOR NEW DISEASE GENES IN STELLA MARIS EST Brain Disorders and 17, CONGENITAL MUSCULAR DYSTROPHY WITH HYPOGLYCOSYLATED ALPHA DYSTROGLYCAN Oncological and Cardio oncological Chemoprevention: targets in the tumor microenvironment MULTIMEDICA ORD Oncology 1 Basic 17, Pagina 258 di 332

259 Study of three dimensional model analysis for evaluation of pelvic volume in patients with hemodynamic instability due to pelvic fracture. Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 17, HEREDITARY EARLY ONSET ATAXIAS: DIAGNOSTIC PROTOCOLS AND THERAPEUTIC STRATEGIES OSPEDALE BAMBINO GESU' CLI EST Brain Disorders and 17, Leukocyte telomere length and risk of ischemic vascular disease in an Italian population. Molise CLI ORD Genes, Genomes 17, and Genetics Biological markers of cancer stem cells Istituto Superiore di Sanita' ORD Oncology 1 Basic 17, RNA sequencing for the detection of progressive HPV lesions Mesenchymal stem cells and islet cotransplantation in diabetic rats: natural chemistry and physical Energy to improve graft revascularization and function by human adipose derived stem cells and biological markers in unipolar vs bipolar depression Molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy of Huntington disease Neurofibromatosis: a spectrum of multifaceted disease The effects of different rehabilitation treatments on left unilateral neglect REGINA ELENA ORD Oncology 2 17, Emilia Romagna EST Endocrinology, Metabolism, Nutrition and Reproductive 17, FATEBENEFRATELLI EST Brain Disorders and 17, Istituto Superiore di Sanita' ORD Brain Disorders and 17, Emilia Romagna ORD Genes, Genomes 17, and Genetics S.CAMILLO CLI ORD Risk, Prevention 17, and Health Behavior Pagina 259 di 332

260 Analysis of HCV persistence in the host and its implications in virus related lymphomagenesis Gene expression profile and epigenetic regulation in human white adipose tissue Predictive markers of bone metastasis in primary breast tumors Study of the role of immune activation and immune senescence in the pathogenesis of atherosclerosis and bone metabolism disorders in HIV infected patients undergoing highly active antiretroviral therapy (HAART) Toscana ORD Oncology 1 Basic 17, AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive 17, Emilia Romagna ORD Oncology 2 17, Lombardia CLI ORD AIDS and Related Research Effects of ALR administration, a physiological antiapoptotic and anti oxidative molecule, on Parkinson's Disease transgenic mice during the progression of the disease. DE BELLIS ORD Brain Disorders and Genetic of Panic disorders BURLO GAROFALO ORD Genes, Genomes and Genetics Web based online follow up for patients with Amyotrophic Lateral Sclerosis Hypertension in childrenadolescents:predictors,risk factors and intra uterine growth retard Sicilia CLI ORD Brain Disorders and Toscana CLI ORD Healthcare Delivery and Methodologies Making sense of safety in clinical critical settings Toscana CLI ORD Healthcare Delivery and Methodologies Pagina 260 di 332

261 POST STROKE DYSPHAGIA:CLINICAL, COGNITIVE AND NEUROANATOMICAL CORRELATES Intensive nutritional counseling in cancer patients undergoing radiotherapy: a randomizedcontrolled trial. Identification of the mechanisms involved in the acquired resistance of human breast cancer cells to the dual EGFR/ErbB 2 tyrosine kinse inhibitor lapatinib Quantitative gait analysis in older adults with Alzheimer s disease and mild cognitive impairment: pathophysiological meaning and possible clinical applications Effect of brain inflammation on AMPA receptor modulation in Alzheimer s disease mouse model CORRELATION BETWEEN BREST ARTERIAL CALCIFICATIONS AT MAMMOGRAPHY AND CORONARY ARTERY CALCIUM SCORE IN ASYMPTOMATIC DIABETIC PATIENTS: TWO SCREENING IN ONE Learning by observation. As a cognitive process can be transformed into a powerful rehabilitation tool in intellectual disabilities. Lazio CLI EST Brain Disorders and SAN MATTEO CLI COF Oncology PASCALE ORD Oncology Toscana CLI EST Brain Disorders and FATEBENEFRATELLI ORD Molecular, Cellular, and Developmental SAN DONATO CLI ORD Cardiovascular and Respiratory SANTA LUCIA CLI ORD Biobehavioral and Behavioral Processes Magnetic resonance imaging based mid and longterm predictors of combined measures of clinical disability and cognitive impairment in patients with multiple sclerosis NEUROLESI CLI ORD Brain Disorders and Pagina 261 di 332

262 Patterns of psychobiological functions in offspring of parents with Panic Disorder and Non Panic Anxiety Disorders: an high risk study. Biomarkers of clinical outcomes in stroke patients. Role of Alfa Melanocortin and Brain Derived Neurotrophic Factor polimorfisms in neurorehabilitation. Randomized controlled trial on the role of telemonitoring for the management of chronic obstructive pulmonary disease (COPD) CHILDREN AUGMENTED REHABILITATION AND ENABLING SPORT FOR SOCIABILITY Adenosine receptor imaging and function, and therapeutic targets in Chronic Heart Failure Novel high cost chemotherapies: clinical use, safety and efficacy after marketing approval in oncology practice Genetic polymorphism and bisphosphonaterelated osteonecrosis of the jaws: a case control study HOXB7/PBX dependent regulation of microrna 221/ 222 QUANTEC:QUantitative Analysis of Normal Tissue Effects in the Clinic.A Multicenter Italian prospective contribute to international research on radiation therapy damage,through a correlation between clinic,imaging,dosimetry and biology. Lombardia CLI ORD Risk, Prevention and Health Behavior S.CAMILLO ORD Brain Disorders and Sicilia CLI ORD Cardiovascular and Respiratory SANTA LUCIA CLI ORD Brain Disorders and Toscana CLI ORD Cardiovascular and Respiratory Lombardia CLI ORD Oncology Emilia Romagna EST Genes, Genomes and Genetics Istituto Superiore di Sanita' ORD Oncology 1 Basic Lombardia CLI ORD Oncology Pagina 262 di 332

263 CORRELATIONS OF THE CLINICO NEUROPHYSIOLOGICAL FEATURES WITH THE HISTOPATHOLOGICAL FINDINGS AND microrna EXPRESSION IN DRUG RESISTANT TEMPORAL LOBE EPILEPSY Istituto Scienze Neurologiche ORD Brain Disorders and Cranioplasty and rehabilitation for brain injured patients Emilia Romagna CLI ORD Brain Disorders and Honey and other hive products free from pharmaceutical or environmental residues: innovative, automated honey bee farming system Istituto Zooprofilattico Sperimentale del Lazio e della Toscana COF Veterinary research of the multi dimensional care model "MI PIACE PIACERMI" for childhood obesity treatment in ambulatory care setting and in patient treatment Liguria CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Target Controlled Infusion Propofol compared with Midazolam plus Fentanyl for moderate sedation in Colonoscopy: a prospective, doubleblind randomized trial. SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney and Urological Systems Prospective evaluation of biological aging and immunesenescence in patients aged 70 years or more receiving adjuvant chemotherapy (CT) for early breast, lung and colo rectal cancer compared to age matched, non cancer patients Veneto CLI ORD Biology of Development and Aging CORONARY ATHEROSCLEROSIS IN THE YOUNG: EARLY DIAGNOSIS AND IDENTIFICATION OF RISK FACTORS FOR SUDDEN DEATH PREVENTION Veneto CLI ORD Cardiovascular and Respiratory In vitro and in vivo physiological cardiac remodelling in response to endurance and strength exercise training SAN RAFFAELE MONTE TABOR ORD Cardiovascular and Respiratory Pagina 263 di 332

264 Association of all trans retinoic acid (ATRA) and trastuzumab for HER 2 positive metastatic breast cancer: a phase II evaluation of ATRA potential immuno modulatory activity for myeloid derived suppressor cells (MDSC). Next Generation Sequencing approaches for Diagnostics of common and rare genetic diseases InTeReSt Project. Integrated Tecnological Rehabilitation of Stroke. Upper limb rehabilitation: efficacy of robot versus neuromodulation treatment and assessment of adaptive central peripheral plasticity Effects of early microbiological diagnosis (molecular tests vs standard) on length of stay in Intensive Care Unit Evaluation of effect of PARP inhibitors with or without irradiation in preclinical models of softtissue sarcomas. functional Magnetic Resonance Imaging techniques: implementation, assessment and validation on the first Italian 7 Tesla Magnet Predictive biomarkers of response to chemoimmunotherapy in melanoma patients Primary prevention of Neural Tube Defects (NTD) by Inositol: the ASBI case control study Improving Quality of Life of Dialysis Patients. A Randomized Trial with a Psychological Intervention I. O. V. CLI ORD Oncology NEUROMED CLI ORD Genes, Genomes and Genetics DON GNOCCHI CLI COF Emerging Technologies and Training in s Emilia Romagna CLI ORD Infectious Diseases and Microbiology Toscana EST Oncology STELLA MARIS ORD Surgical, Biomedical Imaging, and Bioengineering Istituto Superiore di Sanita' ORD Oncology Liguria CLI ORD Risk, Prevention and Health Behavior Lombardia CLI ORD Biobehavioral and Behavioral Processes Pagina 264 di 332

265 Role of PDGFR/CDCP1 pathway in TNBC aggressiveness ISTITUTO TUMORI MILANO ORD Oncology Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia CLI ORD Interdisciplinary Molecular and Training Genotoxic effects related to pesticide exposure: a novel bio monitoring approach IRCCS AOU San Martino IST (Genova) ORD Population and Epidemiology Proteomics and transcriptomics studies to define a new role of REP1: insights in the molecular pathogenesis of Choroideremia Effectiveness and cost effectiveness of eating disorder networks in Italy microrna deregulation in atrial fibrillation: identification of pathogenetic mechanisms and of peripheral blood biomarkers Functional modifications of Substantia nigra pars reticulata neurons firing upon high frequency stimulation in the Subthalamic nucleus: a parallel investigation on Parkinson s disease patients treated with Deep Brain Stimulation and on rat midbrain slice Coronary arteriogenesis with combined pharmacological (dipyridamole and heparin) therapy Iron in cholangiocarcinoma: from understanding the role to possible development of novel treatments SDN ORD Cell Biology Emilia Romagna CLI ORD Biobehavioral and Behavioral Processes SAN DONATO CLI ORD Cardiovascular and Respiratory SANTA LUCIA CLI ORD Brain Disorders and Toscana CLI ORD Cardiovascular and Respiratory HUMANITAS EST Oncology 1 Basic Pagina 265 di 332

266 Immunosuppression and autophagy induced by rapamycin in combination with engraftment of BDNF secreting neural stem cells: a strategy for axonal regeneration and reduction of neuropathic pain in a mouse model of spinal cord injury. Effects of electronic cigarette smoking on preoperative smoking cessations and on post operative complications, functional recovery and quality of life before and after major lung resection for cancer Mesenchymal stem cells and T cells in head and neck squamous cell carcinoma: a unified vision of the tumoral stroma for the identification of new prognostic markers and possible therapeutical targets. Identification of new heart related mirnas as tools for diagnosis and terapy of heart malformations and diseases Development of algorithms for automatic classification of the ECG signals generated by equipment for telemedicine in order to validate diagnoses in cardiological emergency. TUMORIGENIC CELLS OF PANCREATIC CANCER. IN SITUIDENTIFICATION AND CLINICAL SIGNIFICANCE Evaluation of immune competence in naïve versus HAART treated HIV 1 infected individuals to optimize the clinical management Studies on antibodies in single chain format against the HPV16 E6, E7 oncoproteins as a novel therapeutic approach for HPV associated lesions. SANTA LUCIA ORD Brain Disorders and HUMANITAS CLI ORD Risk, Prevention and Health Behavior Toscana ORD Immunology Emilia Romagna ORD Cardiovascular and Respiratory Lombardia CLI ORD Cardiovascular and Respiratory Lazio EST Interdisciplinary Molecular and Training Istituto Superiore di Sanita' ORD AIDS and Related Research Istituto Superiore di Sanita' EST Oncology Pagina 266 di 332

267 Identification of novel functional and biological parameters to predict the response to cardiac resynchronization therapy Novel POCT device for sepsis diagnosis based on a multiassay optical biochip Reducing the costs associated to post stroke rehabilitation: a novel robot assisted treatment protocol SAN MATTEO CLI ORD Cardiovascular and Respiratory Toscana ORD Bioengineering and Technologies Veneto CLI ORD Emerging Technologies and Training in s NETWORK BASED ANALYSIS OF HIGH GRADE SEROUS OVARIAN CANCER: COMPARISON OF PATHWAY ACTIVATION IN THE PRIMARY TUMOR AND MATCHED LOCAL RECURRENCE. ONCOLOGICO DI BARI ORD Oncology 1 Basic Deployment of the trigger tools within the electronic medical record to enhance error detection in Neonatal Intensive Care Units (NICU): a cluster, randomized trial Lombardia CLI ORD Healthcare Delivery and Methodologies DONKEY S MILK DRINK/FOOD OF THE THIRD MILLENNIUM, A SICILIAN PROJECT TO RAISE AN OLD THERAPEUTIC PRODUCT. Istituto Zooprofilattico Sperimentale della Sicilia ORD Immunology Extracellular nucleotides in myeloid leukemia: a role for inflammatory pathways in helping eradicate leukemic stem cells Biological endophenotype associated to the electroconvulsive therapy in major depression. Emilia Romagna ORD Oncology FATEBENEFRATELLI ORD Brain Disorders and Emerging technologies for genome manipulation, detection and characterization of West Nile virus strains Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary Pagina 267 di 332

268 Cardiac stem cells for the treatment of cardiomyopathy induced by antineoplastic drugs IMPROVEMENT OF BREAST CANCER THERAPY BY USING NANOVECTOR DELIVERY SYSTEMS Development of functional nanoparticles for the inhibition of Mannose Binding Lectin, a novel target for stroke therapy MONZINO ORD Cardiovascular and Respiratory Istituto Superiore di Sanita' ORD Oncology Lombardia ORD Brain Disorders and Neuroplasticity, rehabilitation and work ability Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Brain Disorders and Continuity of CAre for severe chronic REspiratory patients (CARE) New nanotools for permeabilization of Brain Blood Barrier and early detection of Alzheimer disease New tools for individual risk assessment and treatment assignment in prostate cancer patients Puglia ORD Healthcare Delivery and Methodologies NEUROMED ORD Emerging Technologies and Training in s Istituto Superiore di Sanita' ORD Oncology Human Mesenchymal Stem Cells as site regulated medicinal cells stimulating endogenous repair mechanisms in tissue injury IRCCS AOU San Martino IST (Genova) ORD Musculoskeletal, Oral and Skin Surgical aortic valve replacement versus transcatheter aortic valve implantation in patients 80 years and older at low surgical risk:the ELDERLY VALVE Trial SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and Respiratory Four dimensions augmented reality navigation system for medical interventions CASA SOLLIEVO SOFFERENZA CLI ORD Surgical, Biomedical Imaging, and Bioengineering Pagina 268 di 332

269 Human Autologous Cardiospheres For The Treatment Of Paediatric Heart Failure OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and Respiratory Cognitive rehabilitation after stroke: a randomized controlled trial to compare the efficacy of different protocols. Investigation of link between Lung Cancer Stem Cells (CSCs) and Epithelial Mesenchymal Transition (EMT) for tumour progression and metastatis Sicilia CLI ORD Brain Disorders and 18, PASCALE ORD Oncology 1 Basic 18, Predictive models of genito urinary and sexual dysfunction after high dose radiotherapy for prostate cancer ISTITUTO TUMORI MILANO CLI ORD Oncology 2 18, THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A CLINICAL, MORPHOLOGIAL CEREBRAL AND LOGICAL COMPARISON STUDY OBESITY AND MALE HYPOGONADISM: WHO COMES FIRST? CHEMOTHERAPY BY SUPERSELECTIVE OPTHALMIC ARTERY INFUSION FOR THE TREATMENT OF INTRAOCULAR RETINOBLASTOMA FATEBENEFRATELLI ORD Brain Disorders and 18, SAN DONATO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 18, Toscana CLI ORD Oncology 2 18, Identification and biological characterization of individuals at risk for hereditary colorectal tumors Emilia Romagna ORD Genes, Genomes 18, and Genetics THE ROLE OF EARLY SCREENING IN PERINATAL DEPRESSION Toscana CLI ORD Risk, Prevention 18, and Health Behavior Pagina 269 di 332

270 Role of hypoxia in glioblastoma metabolism. Looking for new therapeutic strategies to counteract tumor progression and recurrencies Correlation between morphologic alterations of the glomerular filtration barrier and variations of plasmatic and urinary levels of the brain derived neurotrophic factor (BDNF) in rats undergone repetitive transcranial magnetic stimulations (rtms) SAFETY AND EFFICACY OF LICENSED BONE MARROW DERIVED AND INTERFERON gamma PRE TREATED MESENCHYMAL STROMAL CELLS (MSCs) IN PATIENTS AFFECTED BY SEVERE, INTRACTABLE CHILDHOOD ONSET CROHN DISEASE AND JUVENILE IDIOPATHIC ARTHRITIS. A PIVOTAL TRIAL. Metabolic and cardiovascular risk in non obese and obese patients with obstructive sleep apnea: long term follow up Generation of protective immune regulatory environment in murine models of Multiple Sclerosis by CTLA4 Ig mediated tryptophan catabolism. Targeting NF kb to prevent inflammation and neuroplasticity impairment in Neurodegeneration Prediction of response to targeted therapies in esophageal adenocarcinoma patients using an endoscopic biopsies xenograft rat model. Abruzzo ORD Oncology 1 Basic 18, Istituto Superiore di Sanita' ORD Digestive, Kidney 18, and Urological Systems BURLO GAROFALO CLI ORD Immunology 18, Sicilia ORD Population 18, and Epidemiology Umbria ORD Immunology 18, FATEBENEFRATELLI ORD Brain Disorders and 18, I. O. V. CLI ORD Oncology 2 18, Pagina 270 di 332

271 Improving accuracy in cardiovascular disease risk prediction by metabolic markers in the Italian population Lombardia ORD Vascular and 18, Hematology Strategies of psychological support in the context of clinical medical treatments aimed at preserving fertility in oncology, for women of childbearing age and girls of prepubertal age candidate for ovarian tissue banking. REGINA ELENA CLI ORD Risk, Prevention 18, and Health Behavior A study of defensins and innate immunity genes in HPV infection and HPV related cancer and development of a rapid ELINOR test for HPV diagnosis. BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by The Program of Molecular & Endocrinology and Women s Endocrine Health. BURLO GAROFALO CLI ORD Genes, Genomes 18, and Genetics Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 18, early detection of cardiotoxicity in cancer patients ONCOLOGICO DI BARI CLI COF Cardiovascular and 18, Respiratory A MULTIMODALITY APPROACH TO PREVENT THE NEUROLOGICAL DYSFUNCTION IN CARDIAC SURGERY Role of environmental factors on symptomatology in an experimental model of Parkinson s Disease Discovering Genetics of Intracranial Cerebral Heamorrhages (ICH) Optimising Natural Killer (NK) cell activation for liver anti fibrogenic immunotherapy. Veneto CLI ORD Brain Disorders and 18, SANTA LUCIA ORD Brain Disorders and 18, MONDINO ORD Brain Disorders and 18, SAN MATTEO ORD Immunology 18, Pagina 271 di 332

272 Randomized phase II study: treatment with BCG (Bacillus Calmette Guerin) versus Peptide Receptor Radionuclide Therapy (PRRT) in CIS (Carcinoma In Situ) G3 bladder tumor. ANTIOXIDANT PROTECTION IN HIV RELATED NEURODEGENERATIVE DISORDERS Epstein Barr virus infection and risk of developing autoimmune disease Systems biology approach to identify predictive biomarkers of B cell mediated rejection in paediatric kidney transplantation IDENTIFICATION OF GENETIC RISK FOR MELANOMA AND CANCERS OTHER THAN MELANOMA IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA A study to identify and validate predictive biomarkers for clinical outcome after oxaliplatinbased adjuvant chemotherapy (CT) in early stage colorectal cancer (ecrc) and bevacizumab based CT in metastatic colorectal cancer (mcrc) I.E.O. CLI ORD Oncology 2 18, Calabria ORD AIDS and Related 18, Research Istituto Superiore di Sanita' ORD Immunology 18, Veneto ORD Immunology 18, SAN MATTEO CLI ORD Oncology 1 Basic 18, HUMANITAS ORD Oncology 2 18, Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy Emilia Romagna EST Digestive, Kidney 18, and Urological Systems Biomarkers of ischemic damage and epileptogenesis in focal ischemic stroke models CARLO BESTA ORD Brain Disorders and 18, DESIGN OF NOVEL RATIONAL THERAPEUTIC STRATEGIES FOR RET DRIVEN MEDULLARY THYROID CARCINOMA ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 18, Pagina 272 di 332

273 A gender specific approach to cardiovascular drug therapy Genetic and functional analysis of circulating micrornas in multiple sclerosis: potential prognostic biomarkers of disease course? Biomarkers for optimization of Attention Deficit Hyperactivity Disorder (ADHD) pharmacological therapy Deciphering the Transcriptional Signature of Sporadic Brain Arteriovenous Malformations: a Genome Wide Expression Study SAN RAFFAELE PISANA CLI ORD Cardiovascular and 18, Respiratory MAGGIORE EST Brain Disorders and 18, FATEBENEFRATELLI ORD Biobehavioral and 18, Behavioral Processes Istituto Superiore di Sanita' ORD Brain Disorders and 18, Congenital malformations in domestic ruminant calves in southern Italy: a study of the main genetic, toxicological and infective causes Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 18, Programmed cell death and the cross talk between the NF kb and the HIF signaling pathways: implications in hypoxia/ischemiaassociated brain injury Sleep and cardiovascular disturbances as biomarkers of dementia Cognitive changes associated with adjuvant chemotherapy (AC) in breast cancer: a FDG PET study NEUROLESI ORD Brain Disorders and 18, Toscana CLI ORD Brain Disorders and 18, Toscana CLI EST Brain Disorders and 18, Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, Neuroimaging, and Genetics. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 18, Pagina 273 di 332

274 Does adolescents perception of parental and peer drinking habits and lifestyle affect their approach to alcohol consumption? Molise CLI ORD Healthcare Delivery 18, and Methodologies Towards controlling paratuberculosis in cattle throughmarker assisted or genomic selection Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Infectious Diseases 18, and Microbiology Natural Chemistry and Physical Energy to Optimize Stem Cell Therapy of Vascular Diseases Emerging and Re emerging Viral Infections in the Tuscany Region The promise of HPCs and EPCs based therapies on vascular dysfunction in diabetes HOSPITAL PROCEDURES FOR ACUTE HEART FAILURE AND INTEGRATED COUNTRY/HOSPITAL CARE CELIAC DISEASE AND SMALL BOWEL MALIGNANCIES: A POSSIBLE ROLE OF CAPSULE ENDOSCOPY AND DOUBLE BALLOON ENTEROSCOPY FOR EARLY DIAGNOSIS IN HIGH RISK PATIENTS Emilia Romagna ORD Vascular and 18, Hematology Toscana ORD Infectious Diseases 18, and Microbiology Marche ORD Vascular and Hematology Sicilia CLI ORD Cardiovascular and Respiratory MAGGIORE CLI ORD Digestive, Kidney and Urological Systems Prenatal blood group characterization with noninvasive molecular methods for management and prevention of haemolytic disease of the foetus and newborn. Liguria CLI ORD Vascular and Hematology Role of comorbidities in COPD: focus on chronic kidney disease Sicilia CLI ORD Cardiovascular and Respiratory Pagina 274 di 332

275 Technological advancement in deep brain stimulation surgery for Parkinsonian patients: use of neuronavigated frameless system AEQUITAS: Inequality and Quality of regional clinical pathways in diabetes management Advanced implementation of Cognitive Rehabilitation Programs (CRP) for Acquired brain injury (ABI): An integrative systems cares. High fidelity simulation based learning vs conventional education in cardiac arrest management Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresistance MicroRNA signature in colorectal carcinoma: correlation with mutational status of signaling pathways and activity of anti EGFR treatments Quantitative Evaluation of Proprioceptive Acuity in 2D and 3D Environments StressAMI Remote multi disciplinary management program for outpatients with Coronary Heart Disease (CHD) after acute myocardial infarction (AMI) The early identification of the free radical disease of the newborn. New therapeutic strategies. Endogenous hydrogen sulphide (H2S) and airway inflammation of asthma Sicilia CLI ORD Brain Disorders and Marche CLI ORD Population and Epidemiology NEUROLESI CLI ORD Emerging Technologies and Training in s Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Veneto ORD Oncology PASCALE ORD Oncology MAUGERI ORD Bioengineering and Technologies AUXOLOGICO CLI ORD Healthcare Delivery and Methodologies Toscana CLI ORD Healthcare Delivery and Methodologies Piemonte ORD Cardiovascular and Respiratory Pagina 275 di 332

276 Insulin Resistance and metabolic syndrome: predictive and prognostic implications in prostatic cancer patients PASCALE CLI ORD Oncology Cheyne Stokes respiration in heart failure patients: from the identification of individual pathophysiological mechanisms to individualized treatment Impact of tobacco control policies and implementation of tobacco control interventions MAUGERI ORD Cardiovascular and Respiratory Toscana ORD Risk, Prevention and Health Behavior Targeting Bacterial signal transduction to combat vancomycin resistant pathogens. Istituto Zooprofilattico Sperimentale della Sicilia ORD Infectious Diseases and Microbiology Host/Tumor Tailored Clock Chemotherapy: fighting cancer around the clock CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic Hypoxia, necrosis, NF kb activation and proinflammatory genes expression in mesothelioma progression. SAN RAFFAELE PISANA EST Oncology 1 Basic Epidural Anesthesia in patients undergoing mitral valve surgery. A randomized controlled study with clinically relevant end points. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering Molecular characterization of enteric viruses circulating in the infantile population in Sicily CLINICO PATHOLOGIC AND GENETIC STUDY OF THE PREDISPOSITION TO RENAL CANCER AND IDENTIFICATION OF DISEASE GENES IN PATIENTS AND FAMILIES WITH HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER SYNDROME Sicilia ORD Infectious Diseases and Microbiology Lazio CLI ORD Oncology Pagina 276 di 332

277 Genetic determinants of heart failure (HF) Friuli Venezia Giulia ORD Cardiovascular and Respiratory Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of low and intermediate risk prostate cancer IGF PATHWAY IN NEUROENDOCRINE TUMORS: PROGNOSTIC ROLE AND NOVEL TARGET THERAPY Emilia Romagna CLI ORD Oncology SDN CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Autophagy inhibition in chronic myelogenous leukemia stem cells: the way to the cure? IRCCS AOU San Martino IST (Genova) ORD Vascular and Hematology Innovative approaches to assess the role of neutralizing and non neutralizing HIV specific antibodies in AIDS vaccine trials Can we promote beneficial neuroplasticity in the brain of mild cognitive impairment (MCI) and Alzheimer s disease (AD) subjects at their home or care home? TELEmedicine in Global management of aspects in patients with Obstructive sleep apnea (TELEGeCO) Istituto Superiore di Sanita' ORD AIDS and Related Research SAN RAFFAELE PISANA CLI ORD Brain Disorders and AUXOLOGICO CLI ORD Cardiovascular and Respiratory Metformin plus standard chemotherapy: a new weapon to target tumor initiating cells in colorectal cancer treatment and prevention ISTITUTO TUMORI MILANO ORD Oncology Identification of metabolic and immunological parameters predictive for the risk of diseases or fertility problems in periparturient dairy cows Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary Pagina 277 di 332

278 The personalized antidepressant therapy: from the genetic to clinical impact Provincia autonoma Bolzano ORD Emerging Technologies and Training in s Psychotherapy and pharmacological interventions in Social Phobia: an fmri study on neurobiological correlates of treatment induced remission and of response predictors Toscana ORD Brain Disorders and THE IMPACT OF EPIGENOMICS ON THE IDENTIFICATION OF NEW PROGNOSTIC MARKERS AND INNOVATIVE THERAPIES IN NEUROENDOCRINE TUMORS (NETs) AUXOLOGICO ORD Oncology 1 Basic Role of type I IFN in dictating the immunogenicity of chemotherapy and in predicting the therapeutic efficacy of anticancer treatments Genome Wide Methylation Analysis on epigenome of test tube babies to evaluate whether Assisted Reproductive Technology is a safe practice. Istituto Superiore di Sanita' EST Oncology AUXOLOGICO ORD Genes, Genomes and Genetics Molecular investigation and clinical relevance of RET expression in breast cancer GASLINI ORD Oncology 1 Basic EXPERIMENTAL MODELLING OF TUMOR RELAPSE FOR THE DESIGN AND PRE CLINICAL VALIDATION OF COMBINATORIAL APPROACHES OF TARGETED THERAPY IN ORAL CAVITY CARCINOMAS Emilia Romagna ORD Oncology A stem cell platform to identify adverse effects of toxicants: an integrated environmental analysis (food, air and water) MAUGERI ORD Cardiovascular and Respiratory Pagina 278 di 332

279 Use of saliva as biological matrix for non invasive screening of oral cancer ONCOSAL (ONCOlogical Diagnosis by SALiva) Functional connectivity at rest as a tool to investigate the brain plasticity in acquired injured patients Next Generation Sequencing techniques open up new possibilities in the knowledge and diagnosis of hereditary arrhythmogenic diseases and prognostic evaluation of thoracic aortic aneurysms: integration between MRI indexes, biological and biomechanical properties CROB EST Oncology SANTA LUCIA CLI ORD Brain Disorders and Piemonte ORD Cardiovascular and Respiratory Toscana ORD Cardiovascular and Respiratory Development of a Preclinical Model of Peritoneal Carcinomatosis with Cells from patients with Human Gastric Cancer SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic Evaluation of the cognitive load and attention state of patients during neurorehabilitation, focusing on professional car drivers Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro CLI ORD Brain Disorders and Experimental and clinical evaluation of the role of obesity and its treatment in determining and treating decompensation in chronic liver disease Emilia Romagna EST Digestive, Kidney and Urological Systems Dynamics of NF kb in Inflammation SAN RAFFAELE MONTE TABOR ORD Bioengineering and Technologies Development of predictive models based on clinical indicators, dosimetry and bioimaging to describe the dose effect due to laser treatment of skin cancer lesions SAN GALLICANO ORD Oncology Pagina 279 di 332

280 Mediterranean Dietary to prevent conversion of Mild Cognitive Impairment to Alzheimer Disease: a randomized trial. A molecular approach to endometriosis: towards the prediction of the response to hormonal therapy. The neural substrate of transcranial direct current stimulation effects on memory functions in Alzheimer disease. A randomized, controlled study using neuropsychological, [18F]FDG PET and fast optical imaging evaluations. Neuroinflammation in cerebral ischemia: discerning the role of G protein beta/gamma complex translocation in reactive gliosis Study and application of innovative instrumentation and diagnostic protocols in the clinical electrophysiology of vision Role of physical exercise during adjuvant chemotherapy in patients with breast cancer in order to enhance endogenous cannabinoid and reduce nausea and depressive disorders: a randomized controlled trial A longitudinal study to evaluate personality and mood disorders in patients with Multiple sclerosis RNA silencing of the Gene for the Augmenter of Liver Regeneration in Hepatocarcinogenesis in vivo. CARLO BESTA CLI ORD Brain Disorders and Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 19, Toscana CLI ORD Brain Disorders and 19, Sicilia EST Molecular, Cellular, 19, and Developmental Istituto Superiore di Sanita' EST Emerging Technologies and Training in s 19, Emilia Romagna CLI ORD Risk, Prevention 19, and Health Behavior SANTA LUCIA CLI ORD Brain Disorders and 19, DE BELLIS ORD Oncology 1 Basic 19, Pagina 280 di 332

281 Sudden sensorineural hearing loss: searching for new molecular markers. Oxidative stress and genetic susceptibility in Takotsubo Cardiomyopaty A training for dementia family caregivers to improve resilience and well being: a Sicilian perspective. Emilia Romagna ORD Vascular and Hematology 19, Sicilia CLI ORD Cardiovascular and 19, Respiratory NEUROLESI CLI ORD Healthcare Delivery 19, and Methodologies The overexpression of ANGPTL4 is involved in the inhibition of proliferation of human gastric cancer cell line MKN 45. Study of the effects of ANGPTL4 in invasiveness and metastasis. Development of effective approach for cancer therapy. PASCALE COF Oncology 1 Basic 19, A web based intervention to educate patients with type 2 diabetes to healthy lifestyles Emilia Romagna CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 19, PREVALENCE OF AMYLOIDOSES IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNCERTAIN SIGNIFICANCE (MGUS) THROUGH UMORAL, ECHOCARDIOGRAPHICAL AND HYSTOPATHOLOGICAL SCREENING. ROLE OF PROTEOMIC ANALYSIS OF MINOR SALIVARY GLAND IN SYSTEMIC AMYLOIDOSES TYPING Lazio ORD Vascular and 19, Hematology Enhancement of NKG2D ligands induced antitumor response in Hodgkin s lymphomas: ERp5 thiol isomerase and ADAM10 disintegrinmetalloproteinase as possible therapeutic targets. SAN RAFFAELE MONTE TABOR ORD Immunology 19, Transgenic zebrafish model to visualize proliferation in vivo. REGINA ELENA ORD Cell Biology 19, Pagina 281 di 332

282 Evaluation of the therapeutic role of mesenchimal stromal cells in a murine model of systemic lupus erythematosus. Renal cystic disease and ionic channels disease of the kidney: molecular diagnosis by next generation targeted sequencing Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolylhydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy Age related hearing loss: from gene identification to a better diagnosis and prevention HEART KIDNEY INTERACTIONS IN CHRONIC AND ACUTE DECOMPENSATED HEART FAILURE DERMATOLOGIC PROBLEMS IN ONCOLOGICAL PATIENTS. A PREVENTIVE AND THERAPEUTIC APPROACH Defective DNA polymerase beta isoforms as protective factors against Alzheimer's disease NEURAL BASIS OF FREE WILL AND VOLITIONAL INHIBITION IN PARKINSON S AND PHARMACORESISTANT EPILEPTIC PATIENTS Toscana ORD Immunology 19, Emilia Romagna ORD Genes, Genomes 19, and Genetics MAUGERI ORD Digestive, Kidney 19, and Urological Systems BURLO GAROFALO CLI ORD Genes, Genomes 19, and Genetics Emilia Romagna ORD Cardiovascular and 19, Respiratory SAN GALLICANO EST Musculoskeletal, 19, Oral and Skin OASI MARIA S.S. ORD Biology of 19, Development and Aging NEUROMED CLI EST Brain Disorders and 19, DIGITAL KIDS Emilia Romagna CLI ORD Healthcare Delivery 19, and Methodologies Pagina 282 di 332

283 PCA3,ADVANCED MAGNETIC RESONANCE IMAGING TECHNIQUES AND TISSUE AND CIRCULATING MOLECULAR MARKERS IN PROSTATE CANCER: DEFINING A NOVEL DIAGNOSTIC AND PROGNOSTIC ALGORITHM IMPEDANCEMETRY AND OPTICAL COHERENCE TOMOGRAPHY (OCT): NEW TECHNOLOGIES FOR NONINVASIVE ORAL DIAGNOSIS. A TRANSLATIONAL RESEARCH Assessment of falls risk among elderly populations: a multidimensional integrated approach to develop a reliable risk factor score for mass screening. PASCALE CLI ORD Oncology 2 19, Sicilia CLI ORD Musculoskeletal, 19, Oral and Skin SAN RAFFAELE PISANA CLI ORD Brain Disorders and 19, Molecular and in vivo analysis of in vitro generated cancer stem cell like cells: identification of pathways involved in CSC generation and maintenance MAUGERI ORD Oncology 1 Basic 19, PEPTIDE FROM PARIETARIA JUDAICA POLLEN WITH ANTI MICROBIAL ACTIVITY AS A NEW THERAPEUTICAL TOOL: EVALUATION OF INTERACTION WITH THE IMMUNE SYSTEM Traditional Chinese Medicine Herbal Drugs as Modulators of Multidrug Resistance in Cancer Cells Neutrophils in atherosclerosis contribute of sympathetic stress in the initiation and progression of disease from animal model to clinical manifestation Plasma mirnas as prognostic factors in patients with Chronic Lymphocytic Leukemia (CLL) Istituto Superiore di Sanita' ORD Immunology 19, Toscana EST Oncology 2 19, MAUGERI ORD Cardiovascular and 19, Respiratory ARCISPEDALE EST Oncology 2 19, Pagina 283 di 332

284 Language performance as clinical marker of progression from preclinical to overt dementia: multimodal neuroimaging and neuropsychological mechanisms SANTA LUCIA CLI ORD Brain Disorders and 19, Investigation on PPARs mediated effects of statins in renal and cardiovascular damage MONZINO ORD Cardiovascular and 19, Respiratory Development of a DNA microarray for a rapid and reliable detection of pathogens in ready to eat foods. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 19, Microvesicles as mediators of cell to cell interaction in hematological malignancies: biological characterization and clinical relevance in Chronic Lymphocytic Leukemia and Myelodysplastic Syndrome Piemonte ORD Oncology 2 19, Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (15 24 years), in Italy Istituto Superiore di Sanita' CLI ORD Population 19, and Epidemiology NEUROMUSCULAR ELECTRICAL STIMULATION AS A DRIVER OF NEURAL PLASTICITY IN THE CONTEXT OF POST STROKE REHABILITATION NCRpos Vd1 T cells: role of a newly disclosed gamma delta T cell subset in eradicatingtumors, in suppressing HIV 1 replication and in modulating the homeostasis of gut mucosalimmunity. New methods for Non ionizing imaging and guidance of ENDOvascular devices in CArdiac Surgery (NENDOCAS) FATEBENEFRATELLI ORD Brain Disorders and 19, HUMANITAS ORD Immunology 19, Puglia ORD Surgical, Biomedical Imaging, and Bioengineering 19, Pagina 284 di 332

285 Identification of immunological molecular patterns in atherosclerosis. SAN RAFFAELE PISANA ORD Vascular and 19, Hematology PRE CLINICAL DEVELOPMENT OF A HUMAN Emilia Romagna ORD Immunology 19, MONOCLONAL ANTIBODY AGAINST FAS LIGAND FOR THE TREATMENT OF PEMPHIGUS effect of different therapeutic approaches for thyroid related orbitopathy (Graves' orbitopathy) Role of chest physical examination to identifiy patients with early idiopathic pulmonary fibrosis: a multicenter prospective study FLEXIBLE FLATFOOT TREATMENT IN CHILDREN WITH MECHANICAL SOUND VIBRATION THERAPY Establishment of an Interdisciplinary Research Center for Parent/Patient Reported Outcomes in Pediatrics Micro RNA in patients treated with radiotherapy and/or surgery for high risk prostate cancer: a new molecular profile for prognosis and tailored treatment Old and new hypoglycemic agents and incidence of cancer in a large cohort of type 2 diabetic patients: the RIACE Study Lazio CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 0 Emilia Romagna CLI ORD Cardiovascular and Respiratory Sicilia ORD Musculoskeletal, Oral and Skin GASLINI CLI ORD Healthcare Delivery and Methodologies Piemonte CLI ORD Oncology Toscana CLI ORD Risk, Prevention and Health Behavior Determinants of FDG uptake in Hodgkin disease IRCCS AOU San Martino IST (Genova) CLI ORD Bioengineering and Technologies Pagina 285 di 332

286 Relationship between sex hormones and cardiovascular risk: data from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Emilia Romagna CLI ORD Cardiovascular and Respiratory COCAINE CHEST PAIN Emilia Romagna CLI ORD Risk, Prevention and Health Behavior The unawareness of illness and executive dysfunctions in bipolaroutpatients Effect of intensive control of glycemia and associated cardiovascular ( CV ) risk factors on the evolution of severe psychiatric disorders. Intensive Remote Ischemic Conditioning for Effective Cardioprotection in Patients with STelevation Myocardial Infarction. IMPROVED PREDICTION OF ANTIVIRAL TREATMENT OUTCOME IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS GENOTYPE 1 BY PRETREATMENT microrna PROFILING AND HEPATITIS C VIRUS MUTATION ANALYSIS Circulating markers predictors of response in patients with hepatocellular carcinoma (HCC) undergoing chemo embolization (TACE). Piemonte CLI ORD Brain Disorders and Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Toscana CLI ORD Cardiovascular and Respiratory MAGGIORE ORD Digestive, Kidney and Urological Systems Sicilia ORD Oncology PHENOTYPE GENOTYPE CORRELATION IN PATIENTS AFFECTED BY HYPOGONADISM: IMPLICATIONS FOR CLINICAL MANAGEMENT. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 286 di 332

287 Study on transmission patterns of Salmonella enterica serovar 4, 5, 12:i: within pig units Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche CLI ORD Veterinary TESTING A MODEL FOR THE ASSESSMENT OF APPROPRIATENESS OF THE USE OF DRUGS, WITH ACTIONS TO SUPPORT HEALTH AND SOCIAL CARE TO FRAIL ELDERLY PEOPLE IN THE HOME VIA HOME DELIVERY OF THERAPY AND CONSEQUENT REDUCTION IN PHARMACEUTICAL EXPENDITURE WITHIN THE NA Marche CLI ORD Healthcare Delivery and Methodologies Vaccination strategies to prevent infections in splenectomized patients Action and object observation treatment in acute stroke patients SAN MATTEO CLI ORD Immunology NEUROMED ORD Brain Disorders and The relation between fine motor control and psychopathology in children: a general population twin study SAN RAFFAELE MONTE TABOR ORD Population and Epidemiology Benefits of cognitive training in healthy older adults after identification of risk factors for neurodegeneration Multidisciplinary Network for Chronic Pain Prevention. Interregional Model Multimodal approach to the presurgical evaluation of drug resistant epilepsy Biological characterization of Brain Tumor Initiating Cells and their treatment resistance features. MAGGIORE CLI ORD Biology of Development and Aging SAN MATTEO CLI ORD Healthcare Delivery and Methodologies S.CAMILLO CLI ORD Brain Disorders and GASLINI ORD Oncology 1 Basic Pagina 287 di 332

288 New gene variants in Long QT Syndrome using next generation sequencing systems Overcoming chemoresistance in adrenocortical cancer Emilia Romagna ORD Genes, Genomes and Genetics Emilia Romagna ORD Oncology Primary therapy with steroids and IVIG in Kawasaki disease OSPEDALE BAMBINO GESU' CLI ORD Vascular and Hematology Does rehabilitation of mirror neuron system improve brain rhythms and motor performance in dystonia patients? Low Level Laser Therapy for the treatment of radio and chemio induced oral mucositis SDN CLI ORD Brain Disorders and Emilia Romagna CLI ORD Musculoskeletal, Oral and Skin THE ROLE OF 124 IODINE/CG250 PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering Neurodegenerative disorders and tumors: epidemiologic and genetic investigation on their relationship. Influence of genetic factors in the response and in the predisposition to side effects of dopamineagonists in patients with Idiophatic Parkinson Disease Sicilia CLI ORD Population and Epidemiology NEUROLESI ORD Molecular, Cellular, and Developmental Analysis of immunogenicity of putative GPIanchored proteins of Babesia for vaccine and diagnostic purposes Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary Pagina 288 di 332

289 PARP 1 and PARP 2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors in cell lines and in vivo. EARLY START EXERCISE TRAINING AFTER ACUTE DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE: FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, NEUROHUMORAL ACTIVATION AND QUALITY OF LIFE. Bergamot Polyphenol Fraction as a treatment for metabolic syndrome and related cardiovascular complications: focus on mechanisms and bases of in vivo efficacy ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Identification of molecular biomarkers to improve the preoperative diagnosis of follicular type thyroid cancer in the TIR3 cytologic stage as determined by classic FNA cytology Identification of new gender associated biomarkers in metabolic syndrome Toscana ORD Oncology MAUGERI CLI ORD Cardiovascular and Respiratory SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive Emilia Romagna ORD Infectious Diseases and Microbiology Emilia Romagna CLI ORD Oncology Istituto Superiore di Sanita' CLI ORD Cardiovascular and Respiratory Perioperative markers of neurological and lung damage in infants with congenital heart diseases (CHD). A three years follow up study. OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and Respiratory Assessment of rehabilitation outcomes in eldery cancer survivors, compared to older patients without neoplasia, in order to establish a specific care model. DON GNOCCHI CLI ORD Oncology Pagina 289 di 332

290 PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Antigen presentation defects and immunoevasion during colorectal cancer progression Does rehabilitation of mirror neuron system improve brain rhythms and motor performance in stroke and Parkinson s disease patients? Towards Internet based clinical applications at subjects home. Sicilia ORD Infectious Diseases and Microbiology HUMANITAS EST Oncology SAN RAFFAELE PISANA CLI ORD Brain Disorders and Loss related pain as reflected by cortical responses to nociceptive stimuli in healthy subjects and individuals with complicated grief: perception, electrophysiology and a tentative pharmacological approach SANTA LUCIA EST Integrative, Functional, and Cognitive Development of multi mycotoxins immunological methods for food and feed analysis Effect of Glucosamine and Vitamin D on Human Osteoarthritic Cartilage Istituto Superiore di Sanita' ORD Interdisciplinary Molecular and Training RIZZOLI ORD Musculoskeletal, Oral and Skin INSTITUTION OF A REGIONAL MULTIDISCIPLINARY NETWORK FOR FERTILITY PRESERVATION IN CANCER SURVIVORS. CREATION AND IMPLEMENTATION OF AN INNOVATIVE ORGANIZATIONAL MODEL ISTITUTO TUMORI MILANO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 290 di 332

291 CLINICAL, DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING AND MOLECULAR STUDIES BY NEXT GENERATION SEQUENCING OF MIDLINE BRAIN DEFECTS ASSOCIATED WITH PITUTARY HORMONE DEFICIENCIES "mirna and protein expression profile in Colorectal cancer: analysis of their potential as screening, prognosis and therapeutic response biomarkers and as therapeutic targets?" GASLINI CLI ORD Genes, Genomes and Genetics Piemonte EST Oncology A comparison of reduced dose prasugrel and clopidogrel in elderly patients with acute coronary syndrome udergoing early PCI The elderly ACS 2 study Lombardia CLI ORD Cardiovascular and Respiratory Analysis of epidemiology and molecular characteristics of emerging salmonella serovars in Italy Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury: a late preclinical study NEUROLESI ORD Brain Disorders and Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study Physical activity as a strategic measure to reduce drugs consumption and interactions in elderly patients with cardiovascular disease and comorbidity Istituto Superiore di Sanita' CLI ORD Musculoskeletal, Oral and Skin Molise CLI ORD Healthcare Delivery and Methodologies Pagina 291 di 332

292 Evaluation of multi exposure to pesticides in a Sicilian population and biochemical correlates for in vitro induction of insulin resistance by cellular models. Human bronchial hyperresponsiveness in an exvivo model of hyperglycaemia MAUGERI ORD Endocrinology, Metabolism, Nutrition and Reproductive SAN RAFFAELE PISANA ORD Cardiovascular and Respiratory Myocardial Fibrosis in Valvular Heart Disease Lazio CLI ORD Cardiovascular and Respiratory Differentiating Ehrlich carcinoma cells and reducing ascites in rats in vivo. A preclinical study. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Oncology 1 Basic Role of autophagy in the control of regulatory T cells and autoimmunity GABAergic modulation of resting state and stimulus induced activity within the default mode network: a translational investigation on depression. SANTA LUCIA ORD Immunology SANTA LUCIA ORD Brain Disorders and Eco epidemiology of M. bovis in a complex rural zoothenic system and identification of wild animals reservoirs Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary MRI imaging of tumor associated macrophages in the early development of lung and bone metastasis Genetic contribution to acquired Long QT Syndrome in cancer patients receiving Tyrosine Kinase Inhibitors SAN RAFFAELE PISANA EST Oncology MAUGERI CLI EST Oncology Pharmacogenetics in Psychiatry: genetic susceptibility to psychotropic drugs metabolism CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 20, Pagina 292 di 332

293 Analysis of serotype, virulence factor diversity and antibiotic resistance pattern of E. coli strains isolated from ruminant and human samples in Sicily. Istituto Zooprofilattico Sperimentale della Sicilia ORD Infectious Diseases 20, and Microbiology High risk preterm infants: an early diagnostictherapeutic intervention Laser Treatment of Haemophilic Hypertrophic Synovia Evaluation of tolerability and efficacy of sorafenib treatment in patients with hepatocellular carcinoma. Rehabilitation of visual spatial diseases in patients affected by cerebral lesion: a randomised controlled trial. ENVIROMENTAL ENRICHMENT AS A TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS WITH INTELLECTUAL DISABILITY Piemonte CLI ORD Biobehavioral and 20, Behavioral Processes Toscana CLI COF Musculoskeletal, 20, Oral and Skin Sicilia CLI ORD Oncology 2 20, Emilia Romagna CLI ORD Brain Disorders and 20, STELLA MARIS CLI ORD Brain Disorders and 20, Transient Receptor Potential Canonical 1 (TRPC1) in pancreatic cancer: a new actor for NF kb inactivation CASA SOLLIEVO SOFFERENZA ORD Oncology 2 20, The challenge of lymphocyte resistance to drugs and Treg: developing selective approaches to target pathogenic lymphocytes in autoimmunity and GvHD New mechanisms of immune regulation performed by HLA G and characterization of its correlations with HLA E in different pathological conditions BURLO GAROFALO CLI ORD Immunology 20, Liguria ORD Immunology 20, Pagina 293 di 332

294 Beneficial impact of Caribbean dances and Mediterranean diet on patients with cardiovascular risk Identification of molecular and functional imaging predictors in response and toxicity to radio chemotherapy in head and neck cancers. Genetic and malformation risk associated with techniques of fertilization in vitro (IVF): a comparative prospective study of genetic and ultrasound analyses of fetuses conceived with IVF and spontaneously. Accuracy and clinical impact of 68 Ga labeled octreotide analogues PET in diagnosis and staging of duodeno pancreatic neuroendocrine tumours; proposal of a multicenter, prospective, non randomized clinical trial. Circulating micrornas as biomarkers of Atrial Fibrillation T AND B LYMPHOCYTES IN HEPATITIS B PATIENTS: ROLE IN ACUTE IN CHRONIC INFECTION. INNATE IMMUNE CELL RESPONSE TO HYPOXIC MICROENVIRONMENT: IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS FOR JUVENILE IDIOPATHIC ARTHRITIS ECTODERMAL DYSPLASIA: EPIDEMIOLOGICAL, CLINICAL, GENETICAL STUDY AND PATIENTS NEEDS ANALYSIS. Puglia CLI ORD Cardiovascular and 20, Respiratory Toscana CLI ORD Oncology 2 20, BURLO GAROFALO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20, ARCISPEDALE CLI ORD Surgical, Biomedical Imaging, and Bioengineering 20, MONZINO CLI EST Cardiovascular and 20, Respiratory Emilia Romagna ORD Immunology 20, GASLINI ORD Immunology 20, BURLO GAROFALO CLI ORD Population 20, and Epidemiology Pagina 294 di 332

295 Immunomodulatory effects of umbilical cord Wharton jelly derived human adult mesenchymal stem cells (hucms) on circulating Tc subsets of patients with systemic autoimmune disorders such as: 1) Type 1 diabetes mellitus (T1DM); 2) Connective tissue diseases Molecular pathology of colorectal carcinoma: basis for individual risk assessment and inherited cancer predisposition syndrome. A prospective study in consecutive patients enrolled in ULSS21. Cardiotoxicity from antracyclines and trastuzumab in the adjuvant treatment of breast cancer: early identification of high risk patients with a panel of biomarkers compared to traditional ecocardiographic evaluation. Integration of an inpatient clinical research in medical oncology within an intensity of care focused hospital (ICFH) model Vitiligo as model for autoinflammatory induced degenerative disease. Role of Phosphoinositide 3 kinase class II beta in platelet function and arterial thrombosis Umbria ORD Immunology 20, Veneto ORD Oncology 1 Basic 20, I. O. V. CLI ORD Oncology 2 20, Liguria CLI ORD Healthcare Delivery 20, and Methodologies SAN GALLICANO CLI EST Musculoskeletal, 20, Oral and Skin MULTIMEDICA ORD Vascular and 20, Hematology Environmental and biological monitoring of exposure to traffic related air pollution for outdoor workers and evaluation of genotoxic and cardiovascular effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Population 20, and Epidemiology Obesity as an intermediate phenotype of cardiovascular disease and cancer: in vivo and in vitro studies on tissue factor expression and related processes Molise ORD Vascular and 20, Hematology Pagina 295 di 332

296 BCL XL GENE EXPRESSION QUANTIFICATION FOR MINIMAL RESIDUAL DISEASE DETECTION IN PMF: A NEW MOLECULAR MARKER TO PREDICT EARLY RELAPSE IN JAK2V617F NEGATIVE PATIENTS. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 20, New frontiers in breast imaging: contrast enhanced digital mammography. performance of contrast enhanced spectral mammography (CESM SenoBright) in presurgical evaluation of extent of malignancy in a population of women with breast cancer. Molecular characterization of Legionella pneumophila environmental strains as tool to Improve risk assessment analysis in hospital acquired Legionnaires disease Hepato protective and anti oxidant effects of silibinin in a rat model of non alcoholic fatty liver disease. I.E.O. CLI ORD Oncology 2 20, Istituto Superiore di Sanita' CLI ORD Infectious Diseases 21 0 and Microbiology Calabria ORD Endocrinology, Metabolism, Nutrition and Reproductive Purification and utilization of adult adipose derived mesenchymal stem cells (ADMSC) from rat adipose tissue and their transdifferentation toward endothelial cells for kidney function recovery Istituto Zooprofilattico Sperimentale della Sicilia ORD Digestive, Kidney and Urological Systems Path to cure CML and Ph+ leukemias Emilia Romagna CLI ORD Oncology Validation and improvement of an algorithm on the therapeutic treatment of vertebral metastases RIZZOLI CLI ORD Oncology Pagina 296 di 332

297 EUS GUIDED CRYOTHERMOABLATION IN PATIENTS WITH UNRESECTABLE LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA: EFFICACY IN IMPROVING THE RATE OF RESECTABILITY AND REDUCING THE TUMORAL MASS. SAN RAFFAELE MONTE TABOR CLI ORD Oncology Generic substitution of antidepressant drugs NEUROLESI CLI ORD Brain Disorders and Mechanism of action of zoledronic acid in breast cancer Organized cervical cancer screening programs: evaluation of outcomes and identification of critical points, in Italian areas covered by Cancer Registries Functional and genetic study of innate immunity in early onset Inflammatory Bowel Disease. PASCALE ORD Oncology C.R.O. AVIANO ORD Population and Epidemiology BURLO GAROFALO CLI ORD Genes, Genomes and Genetics Unbalance of NGF receptor expression as a novel pathogenetic mechanism in inflammatory diseases: therapeutic potential of p75ntr inhibitors OSPEDALE BAMBINO GESU' ORD Immunology DERIVATION AND VALIDATION OF A MODEL FOR MONITORING PATTERN OF CARE AND OUTCOME OF ACUTE CORONARY SYNDROME Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Identification of a multi SNP profiling to predict metabolic syndrome in children OSPEDALE BAMBINO GESU' CLI ORD Genes, Genomes and Genetics Eradicating HIV from Infected Cells with a Trojan Integrase Emilia Romagna ORD AIDS and Related Research Pagina 297 di 332

298 New genes CHI related: a lesson to understand mechanisms behind the insulin secretion. BURLO GAROFALO ORD Endocrinology, Metabolism, Nutrition and Reproductive Implementation of an enhanced recovery after surgery program in different surgical specialties in multiple Italian institutions. SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery and Methodologies Disorders of consciousness: longitudinal Italian study on Vegetative State and Minimally Conscious State (ITADOCs) MOLECULAR ANALYSIS OF PRIMARY CUTANEOUS CD8+ AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T CELL LYMPHOMA CARLO BESTA CLI ORD Population and Epidemiology MAGGIORE ORD Genes, Genomes and Genetics Development, Implementation and Evaluation of a Complex Program Focused on Quality of Life Assessment in the Palliative Care Network of the Ligurian Region IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery and Methodologies New basic and clinical approaches to improve diagnosis and therapeutics strategies in extreme phenotypes of type 2 diabetic patients MICROBEAM STEREOTACTIC RADIOSURGICAL SUBTHALAMOTOMY AS A NEW SYMPTOMATIC TREATMENT FOR PARKINSON S DISEASE Piemonte EST Endocrinology, Metabolism, Nutrition and Reproductive NEUROMED EST Brain Disorders and Pagina 298 di 332

299 Title: Health care associated infections prevention and management of antimicrobial therapy through the development of a database and an artificial neural network: the microbiologist at the bedside. Sonochemotherapy. A new combined approach of sonoporation plus chemotherapy for the treatment of poorly chemosensitive cancers. Vitamin D supplements in geriatric major depression A NEW BANK FOR REGENERATIVE MEDICINE: MAY DISCARDED PLACENTA TISSUE BE UTILIZED? Study and control of anticipatory movements followed to adaptation of sequential learned motorial gestures related to subjects intensively trained: FMRI and DTMRI study Marche ORD Infectious Diseases and Microbiology Emilia Romagna ORD Oncology Emilia Romagna CLI ORD Brain Disorders and Piemonte ORD Immunology NEUROLESI COF Integrative, Functional, and Cognitive ROLE OF GENE POLYMORPHISMS IN PREDICTING EFFICACY AND TOXICITY IN DIFFUSE LARGE B CELL LYMPHOMA PATIENTS TREATED WITH R CHOP IMMUNOCHEMOTHERAPY Toscana ORD Oncology MOLECULAR CHARACTERIZATION OF BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM Synergistic anticancer effects of the ibraf, imek1/2 and ipi3k in melanoma and possible strategies to overcome the drug resistance MAGGIORE ORD Genes, Genomes and Genetics PASCALE EST Oncology Pagina 299 di 332

300 Impact assessment of Training Centre for Integrated Health Emergency Emilia Romagna CLI COF Healthcare Delivery and Methodologies Topoisomerase I from Leishmania infantum as potential chemotherapeutic target Istituto Zooprofilattico Sperimentale della Sicilia ORD Biological Chemistry and Macromolecular Biophysics Prospective study to identify mechanisms of resistance to taxanes in breast cancer. Epigenetic alterations in nicotine and alcohol dependence New protocols for plasticity induction and motor recovery in stroke patients Protocol proposal about fixture abutment connection assessment by 3D microtomography analysis to avoid dental implant failure. Myo inositol: in vitro and in vivo study on sperm quality of oligo astheno teratozoospermia (OAT) patients The role of the urokinase/urokinase receptor (upa/upar) system in Inflammatory Bowel Disease (IBD) Innovative Tool for Uni compartmental Knee Prostheses & Evolution of Guidelines. Emilia Romagna ORD Oncology Emilia Romagna ORD Brain Disorders and FATEBENEFRATELLI ORD Brain Disorders and Istituto Superiore di Sanita' ORD Bioengineering and Technologies Istituto Superiore di Sanita' CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive HUMANITAS ORD Digestive, Kidney and Urological Systems RIZZOLI ORD Surgical, Biomedical Imaging, and Bioengineering 21, Pagina 300 di 332

301 Development of minimally invasive techniques in treatment of skull base tumors. Anatomic and clinical study. Markers of gluten sensitivity in unipolar and bipolar disorders Role of PPAR (Peroxisome Proliferator Activated Receptors) alpha ligands in modulating allergeninduced inflammatory and dysfunctional alterations of the airways. ASSESSMENT OF THE PHYSIOPATHOLOGICAL MECHANISMS UNDERLYING GLIAL AND NEURONAL DAMAGE AND EVALUATION OF THE NEUROPROTECTIVE EFFECTS EXERTED BY RECOMBINANT ERYTHROPOIETIN AND OTHER TISSUE PROTECTIVE MEDIATORS. Cytokine secretion phenotype of airway immune cells in inflammatory and infectious diseases of the human lung Usher Syndorme: from the Italian epidemiology to the discover of novel related genes. INDIVIDUALIZING DURATION OF ANTITIC THERAPY IN HOSPITALIZED PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA Lazio CLI EST Surgical, Biomedical Imaging, and Bioengineering 21,5 0 Toscana CLI ORD Immunology 21, MAUGERI ORD Cardiovascular and 21, Respiratory Sicilia CLI EST Brain Disorders and 21, Toscana ORD Immunology 21, BURLO GAROFALO ORD Genes, Genomes 21, and Genetics MAGGIORE CLI ORD Infectious Diseases 21, and Microbiology Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in the aetiopathogenesis of the Williams Beuren Syndrome. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 21, relevance of detecting EpCAM+ tumour cells in peripheral blood and in bone marrow in patients with hepatocellular carcinoma Piemonte CLI ORD Digestive, Kidney 21, and Urological Systems Pagina 301 di 332

302 First international Inter Group Study for classical Hodgkin s Lymphoma in Children and Adolescents EuroNet PHL C1 Emilia Romagna CLI ORD Oncology 2 21, Why are MSCs therapeutic? MAGGIORE ORD Cell Biology 21, Project title: Safety and Effectiveness of H.E.L.P. apheresis in microcirculatory diseases refractory to standard care Emilia Romagna CLI COF Cardiovascular and 21, Respiratory Development of a multiplex standard polymerase chain reaction assay for identification of infectious agents from aborted ruminants clinical samples Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 21, The ASAA study. Antibiotics vs. Surgery in Acute Appendicitis: an intention to treat prospective randomized controlled study Conservative and surgical care pathway in patients with neuromuscular scoliosis Major Depression in Systemic lupus erythematosus: a possible link between neurobiological aspects and biohumoral milieu Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 21, RIZZOLI CLI ORD Musculoskeletal, 21, Oral and Skin Toscana ORD Brain Disorders and 21, Advanced magnetic resonance imaging in the study of multiple osteochondromas: correlations with genetic mapping, biochemical analysis and histology Istituto Scienze Neurologiche ORD Surgical, Biomedical Imaging, and Bioengineering 21, Impact of thrombophilia on risk of perinatal stroke in neonates: a prospective study OSPEDALE BAMBINO GESU' CLI ORD Vascular and 21, Hematology Transcranial direct current stimulation in SCI rehabilitation: a translational study. Piemonte ORD Brain Disorders and 21, Pagina 302 di 332

303 Efficacy of Bone marrow concentrated cells(bmc) as scaffold for cellular differentiation in arthroscopic rotator cuff repair: A randomized controlled trial The role Inflammation and wound healing mechanisms in lung cancer biological behaviour and outcome prediction after surgical resection REGINA ELENA CLI ORD Musculoskeletal, 21, Oral and Skin HUMANITAS ORD Oncology 1 Basic 21, Development of an experimental biological protocol for the characterisation of new buccal and transbuccal dosage forms for localand systemic pharmacological therapies Istituto Zooprofilattico Sperimentale della Sicilia ORD Bioengineering 21, and Technologies Gene Expression Profiles of the aneurysm wall and Genome wide screen in patients with Ruptured and Unruptured Intracranial Aneurysm: are there genetic determinants identifying Ruptured Aneurysm and patients at risk of rupture in Aneurysm Population? CARLO BESTA EST Vascular and 21, Hematology Study of bacterial, parasitic and viral pathogens found in animal and vegetables food matrices, currently not covered by the national and European laws, with particular reference to the list of zoonotic agents. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 21, IMMUNE RESPONSE AND VDRS POLYMORPHISMS IN INFANTS AND CHILDREN EARLY SUPPLEMENTED WITH ORAL CHOLECALCIFEROL. Lombardia CLI ORD Immunology The Avatar Bologna Project Emilia Romagna CLI ORD Risk, Prevention and Health Behavior Diabetes and neurocognition: the role of glycemic control and vascular comorbidities in elderly people with diabetes NEUROLESI CLI EST Biology of Development and Aging Pagina 303 di 332

304 ezetimibe in patients Undergoing heart Surgical revascularization: the ZEUS Trial. Enhancing the efficacy and the efficiency of obesity treatment through the psicological assessment of obese patients. Imaging in clinical MR spectroscopy: reconstruction of high spatial resolution metabolic maps Smoking behavior in patients with established ischemic vascular disease from the Moli sani cohort study Learn and live: extended training for a safer hospital Pediatric headaches: utility of "RED FLAGS" in the use of CT and MRI Lazio CLI ORD Cardiovascular and Respiratory Piemonte CLI ORD Risk, Prevention and Health Behavior Toscana ORD Surgical, Biomedical Imaging, and Bioengineering Molise ORD Population and Epidemiology HUMANITAS CLI ORD Healthcare Delivery and Methodologies Sicilia CLI ORD Healthcare Delivery and Methodologies mirna and vascular diseases: role of mir149, mir155, mir31, mir126, mir17 3p in endothelial dysfunction IRCCS AOU San Martino IST (Genova) ORD Vascular and Hematology In Vivo Detection of Cholangiocarcinoma at ERCP: Confocal Laser Endomicroscopy and Intraductal Aspiration. Sicilia CLI ORD Oncology Antioxidants in metabolic syndrome SAN DONATO ORD Endocrinology, Metabolism, Nutrition and Reproductive EARLY NEURAL CONNECTIVITY DEVELOPMENT: A PRENATAL FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Veneto ORD Biology of Development and Aging Pagina 304 di 332

305 The use of autologous adult, allogenic juvenile, and combined juvenile adult cartilage fragments for the repair of chondral defects. In vivo study on a goat model. Effects of sleep disturbances on the occurrence of post extubation respiratory failure and related mortality The efficacy of an HRV biofeedback training in patients with chronic Heart or Respiratory Failure Corrective cardiac surgery in utero: a new frontier for the management of the unborn child and for perinatal medicine Social dysfunction and social perception in schizophrenic patients and its relationship with symptom severity, assessed by behavioral and functional magnetic resonance studies. Phase II study to evaluate activity and toxicity of gemcitabine in combination with pemetrexed in long infusion in pretreated metastatic colorectal cancer patients Yin Yang 1 (YY1) overexpression in patients suffering osteosarcoma Assessment of left ventricular systolic and diastolic dysfunction in patients with pre clinical and overt heart failure. Study of a Novel RNA mediated Transcriptional Activation mechanism, Called RNA Memory as Therapeutic Stategy for Human Diseases. Piemonte ORD Musculoskeletal, Oral and Skin Emilia Romagna CLI ORD Cardiovascular and Respiratory MAUGERI CLI ORD Risk, Prevention and Health Behavior Toscana ORD Cardiovascular and Respiratory Abruzzo ORD Brain Disorders and Emilia Romagna CLI ORD Oncology SDN CLI ORD Oncology (3) Sicilia CLI ORD Cardiovascular and Respiratory Sicilia ORD Genes, Genomes and Genetics Pagina 305 di 332

306 Clinic evaluation of Cervista(TM)HR HPV as Screening Test Abruzzo CLI ORD Interdisciplinary Molecular and Training Preclinical use of advanced magnetic resonance imaging and histopathology to improve diagnosis of neoplastic lesions in chronic hepatitis. SAN RAFFAELE MONTE TABOR ORD Surgical, Biomedical Imaging, and Bioengineering Prognostic role of melanoma follow upa prospective randomised study Development of a new synthetic coronary bypass graft for coronary artery bypass grafting Pulmonary Rehabilitation in Lung Cancer surgical patients. I.E.O. CLI ORD Oncology Toscana ORD Surgical, Biomedical Imaging, and Bioengineering SAN RAFFAELE PISANA CLI ORD Cardiovascular and Respiratory Towards the understanding of the molecular bases of HIV latency SAN RAFFAELE MONTE TABOR ORD AIDS and Related Research Thyroid hormone treatment as a novel therapeutic strategy to prevent post ischemic cardiac remodeling TERAHERTZ SPECTROSCOPY AND IMAGING FOR DIAGNOSTICPURPOSES Vaccination with autologous dendritic cells loaded with autologous tumor lysate/homogenate combined or not with immunomodulating radiotherapy and/or preleukapheresis IFN alpha in patients with advanced melanoma: a randomized proof of principle phase II Toscana ORD Cardiovascular and Respiratory Lazio ORD Surgical, Biomedical Imaging, and Bioengineering Emilia Romagna CLI ORD Oncology Pagina 306 di 332

307 Tubercolosis in neonates and infants: novel OSPEDALE BAMBINO approach to the diagnosis and to the management. GESU' CLI ORD Infectious Diseases 22,5 0 and Microbiology New methods for diagnosis and prevention of potential celiac disease In vitro behaviour of bone cells under disuse simulating hypoxia conditions Evaluation of high frequency percussive ventilation on cystic fibrosis and other restrictive lung diseases Possible role of injured vascular cell derived microvesicles on pericyte vessel destabilization. Evaluation of candidate treatments for mevalonate kinase deficiency (MKD): pre clinical study on new cellular and animals models and biological features of multiple myeloma patients treated with new agents and presenting with extramedullary disease at diagnosis and at relapse. Observational prospective study of pulmonary ground glass nodules: meaning and efficacy of CAD detection for neoplastic patients. Identification of mechanisms of resistance to EGFR tyrosine kinase inhibitors in non small cell lung carcinoma (NSCLC) and monitoring the molecular evolution of lung tumors BURLO GAROFALO CLI ORD Digestive, Kidney 22, and Urological Systems RIZZOLI ORD Cell Biology 22, BURLO GAROFALO ORD Cardiovascular and 22, Respiratory Piemonte ORD Oncology 1 Basic 22, BURLO GAROFALO CLI ORD Immunology 22, Piemonte ORD Oncology 2 22, I. O. V. CLI ORD Oncology 2 22, PASCALE CLI ORD Oncology 2 22, Pagina 307 di 332

308 FUNCTIONAL AND STRUCTURAL EVALUATION OF CDKN2A UNCLASSIFIED VARIANTS (UVs) PREDISPOSING TO FAMILIAL MALIGNANT MELANOMA Neutrophil gelatinase associated lipocalin (NGAL) and Matrix metalloproteinase(mmp) 2 and MMP 9 as biomarkers of urothelial carcinoma development and progression Cognitive and neurophysiological markers of nonamnesic mild cognitive impairment (MCI) and dementia with Lewy bodies (DLB) Multi criteria decision approach (MCDA) to analyse priority setting decisions in the context of a transition from acute focused towards chronic care focused healthcare systems: implications for the Italian SSN Pharmacogenomics of clopidogrel in acute coronary syndromes. Adipose mesenchymal stem cells for the management of Crohn s disease fistulas I. O. V. ORD Oncology 1 Basic 22, C.R.O. AVIANO ORD Oncology 2 22, NEUROLESI ORD Brain Disorders and 22, Emilia Romagna CLI EST Healthcare Delivery 22, and Methodologies Emilia Romagna CLI ORD Cardiovascular and 22, Respiratory Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering Omic's in Blastocoele Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 308 di 332

309 Evaluation of the individual susceptibility through the analysis from "buccal swab" of genetic polymorphisms of phase 1 enzymes(cyps) and phase 2 (GSTs) in subjects exposed to benzene andethical aspects, liceity of genetic screening application in Obstructive sleep apnea syndrome and hypercoagulation Negative pressure therapy : model of Haealth management Hospital to territory Study of the activity of autonomic nervous system during sleep by means of pulse wave amplitude (PWA) variations detected by photopletismography. Istituto Superiore di Sanita' ORD Risk, Prevention and Health Behavior SAN DONATO CLI ORD Cardiovascular and Respiratory Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering Emilia Romagna ORD Emerging Technologies and Training in s Molecular, immunological and clinical study on echinococcosis in natural and human hosts Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Infectious Diseases and Microbiology Impact of pioneering approaches to gait rehabilitation in Parkinson s disease: a controlled study of robot gait training and transcranial direct current stimulation effects Marche CLI ORD Brain Disorders and Oxidative stress and fat profile in neuromuscular disorders with pediatric onset before and after a rationally modified dietary regimen. Istituto Scienze Neurologiche CLI ORD Brain Disorders and Evaluation of triethylamine / triethylamine oxidized (TMA / TMAO) in patients with autosomal dominant familial hypercholesterolemia (ADH) Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive Pagina 309 di 332

310 Therapeutic potential of curcumin in ovarian cancer Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. ESTABLISHMENT OF A SENIOR EMERGENCY ROOM FOR FRAIL ELDERLY AND PATIENTS WITH DEMENTIA Olfactory dysfunction: neurophysiological, neuropsychological and functional magnetic resonance assessment for the early detection of Alzheimer's disease. Role of insulin resistance in liver and gastrointestinal precancerous conditions development and evolution: cross sectional prevalence study and secondary prevention interventional strategies in Veneto Region high risk populations. Puglia ORD Oncology Toscana ORD Population and Epidemiology Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Toscana CLI ORD Brain Disorders and I. O. V. CLI ORD Oncology Obstructive sleep apnea as a cause of resistant hypertension: impact of CPAP treatment on blood pressure and number of antihypertensive medications SAN RAFFAELE MONTE TABOR CLI ORD Risk, Prevention and Health Behavior GENETIC FOCUSING IN SENSORINEURAL HEARING LOSS AND SPECIFIC LANGUAGE IMPAIRMENT IN SICILY Sicilia CLI ORD Brain Disorders and Pagina 310 di 332

311 REHABILITATIVE APPROACH TO THE COGNITIVE DECLINE IN PARKINSON'S DISEASE: A CLINICAL AND FUNCTIONAL IMAGING STUDY Calabria CLI ORD Brain Disorders and Effects of IL 7 administration in vivo on homing and tissue related distribution of T cells SAN RAFFAELE MONTE TABOR ORD AIDS and Related Research Role of mitochondria in ovarian cancer: diagnosis and prognosis BACKGROUND VALUES OF ESSENTIAL TRACE ELEMENTS, TOXICANTS AND THEIR METABOLITES IN THE ITALIAN GENERAL POPULATION Intrabone cord blood transplantation for hematological malignancies Characterization of a mouse model of creatine transporter deficiency:development of new therapeutic strategies for an untreatable inherited disorder of metabolism An Innovative Microchip based Deep Brain Stimulation Device for Improved Treatment and Rehabilitation of Parkinson s Patients Visual function in newborn at term and preterm at risk of brain damage: a new neonatal assessment visual european grid and correlations with neurodevelopmental outcome at short term (Naveg Project) Emilia Romagna ORD Oncology 1 Basic MAUGERI ORD Population and Epidemiology Emilia Romagna CLI ORD Vascular and Hematology STELLA MARIS ORD Brain Disorders and GALEAZZI ORD Brain Disorders and MONDINO CLI ORD Integrative, Functional, and Cognitive COMPREHENSIVE APPROACH TO THE TREATMENT OF ATRIAL FIBRILLATION: NEW MULTIDISCIPLINAR FLOW CHART FOR EARLY DIAGNOSIS AND EARLY TREATMENT SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and Respiratory Pagina 311 di 332

312 WIRVA Wireless control of Internal Routes and Vital signs monitoring for patients moving within hospital Areas Sicilia ORD Healthcare Delivery and Methodologies Metabolomic of newly diagnosed acute myeloid leukemia (AML) patients undergoing intensive treatment. SAN RAFFAELE MONTE TABOR ORD Oncology The role of TRIM50 in the aggresome formation and clearance of polyubiquitinated and misfolded proteins: implications for Williams Beuren syndrome CASA SOLLIEVO SOFFERENZA ORD Cell Biology Global prospective evaluation of the in vivo clinical efficacy and of the ex vivo bio mechanical properties of the biological meshes employed in thoracic abdominal pelvic wall reconstructive surgery. Echografic detection of Hepatocellular carcinoma with a 3 dimensional ultrasound with contrast media in cirrhotic patients. Neurobiological correlates of long term outcome predictors of Eating Disorders: a multidisciplinary approach using genetic polymorphisms analyses, fmri, and psychiatric assessment, repeated before and after a cognitive behavioural treatment. Wnt related proteins in the peripheral blood as potential predictors of response to lithium treatment in bipolar patients. Veneto ORD Surgical, Biomedical Imaging, and Bioengineering 23,25 0 Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering 23, Toscana CLI ORD Brain Disorders and 23, NEUROMED ORD Brain Disorders and 23, Pagina 312 di 332

313 Activation of innate host defense mechanisms in multiple sclerosis: analysis of potential involvement of Toll Like Receptor (TLR)4, TLR9 and MyD88 adaptor using novel immunomodulatory compounds NEUROLESI ORD Immunology 23, Identification of molecular markers to determine NEUROMED ORD Oncology 2 23, new therapeutic strategies for Phase II Trials (GCP criteria) in patients with Glioblastomas Development of methods to sub type Clostridium botulinum from animals to support epidemiological investigations and set up of a sera and vaccine bank for treatment and prevention of type C and D animal botulism Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 23, research in breast cancer metastases to the brain: a multidisciplinary approach to identify molecular pathways for the development of new therapeutic strategies CLINICAL PATHWAYS ON THE MANAGEMENT OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS IN DIFFERENT STAGES OF DISEASE ROLE OF DAMAGE ASSOCIATED MOLECULAR PATTERNS (DAMPs) IN EXACERBATING LUNG GRAFT ISCHEMIA REPERFUSION (IR) INJURY From new cancer drug registries to appropriateness of care and determinants of (regional) variability: implementing a new monitoring system to evaluate evidence based guidelines I.E.O. CLI ORD Oncology 2 23, SAN RAFFAELE PISANA CLI ORD Brain Disorders and 23, Lazio ORD Immunology 23, Emilia Romagna CLI ORD Oncology 2 23, Pagina 313 di 332

314 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility: prevention and treatment in Italian and Sudanese/Ethiopian populations. "Preventative strategies against dementia: clinical, biological and anthropological impact of longterm treatment with anti oxidants in mild cognitive impairment" HIGH FIELD STRENGTH MR SCANNERS (3 TESLA) TO DETECT MARKERS FOR EVALUATING DRUG RESISTANCE IN TEMPORAL LOBE EPILEPSY MEDEA ORD Brain Disorders and 23, Umbria CLI COF Brain Disorders and 23, Calabria CLI ORD Brain Disorders and 23, A multicentric case control study on Gastrointestinal (GI) microbiota, diet and immune system activation: effects of microbial modulation in healthy subjects and patients affected by Irritable Bowel Sydrome and Inflammatory Bowel Disease. Istituto Superiore di Sanita' ORD Infectious Diseases 23, and Microbiology Impact of patient's and physician's gender on the prescriptions of cardiovascular and antidiabetic pharmacological agents in a community setting Systemic Treatment plus Radiofrequency Ablation versus systemic treatment alone in patients with non resectable colorectal liver metastases. TRAUMATIC BRAIN INJURY: A FAMILY PSYCHOLOGICAL INTERVENTION Small fields in radiotherapy: dose calibration and plan verifications for the modern, non standard treatment machines. Toscana CLI ORD Cardiovascular and Respiratory Emilia Romagna CLI ORD Oncology NEUROLESI CLI ORD Integrative, Functional, and Cognitive Toscana CLI ORD Oncology Pagina 314 di 332

315 Early detection of vascular complication in patients wit systemic sclerosis Development of innovative reference test phantom for quality assurance in advanced medical imaging. Effects of the prebiotic inulin in the treatment of chemotherapy induced mucositis and related alterations in gut microbiota IDENTIFICATION OF NEURODEVELOPMENTAL RISK FACTORS FROM GESTATION TO BIRTH: PRENATAL DIAGNOSIS OF NEUROLOGICAL DISEASE, MANAGEMENT IN NICU AND EARLY REHABILITATION CARE.ESTABLISHMENT OF A MULTIDISCIPLINARY DIAGNOSTIC AND THERAPEUTIC PATHWAY FOR THE NEWBO Sicilia CLI ORD Immunology Toscana ORD Surgical, Biomedical Imaging, and Bioengineering DE BELLIS ORD Oncology Sicilia CLI ORD Brain Disorders and Array CGH analysis of copy number variation (CNV) in patients with Hemophilia A: possible relationship with FVIII inhibitor development CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes and Genetics A COMMON SCORE TO EVALUATE CLINICAL AND LOGICAL ASPECTS OF ACUTE MYELOID LEUKEMIA (AML) IN ELDERLY PATIENTS AIMED TO ENSURE HOMOGENEOUS DIAGNOSTIC AND TREATMENT CRITERIA IN THE HAEMATOLOGY UNITS IN EMILIA ROMAGNA. Unravelling the genetic defects in Maturity Onset Diabetes of the Young: a next generation sequencing approach Emilia Romagna CLI ORD Oncology Emilia Romagna ORD Genes, Genomes and Genetics Pagina 315 di 332

316 Bioethical issues in the use of the new criteria for Prodromal Alzheimer disease: disclosure of the diagnosis, clinical trials, social impact. Inflammation, angiogenesis and micrornas in malignant mesothelioma. Identification of high risk profiles in low HDL dyslipidemia Diagnosis and Management in Sicilian patients with Rare Diseases leading to Intellectual Disability: a Community evaluation and shared plan of improvement. Type 2 Diabetes Mellitus and Alzheimer's Disease: towards a common treatment? FATEBENEFRATELLI ORD Brain Disorders and Toscana ORD Oncology 1 Basic Toscana ORD Cardiovascular and Respiratory OASI MARIA S.S. CLI ORD Healthcare Delivery and Methodologies Piemonte CLI ORD Integrative, Functional, and Cognitive SERIOUS GAMES IN VIRTUAL REALITY FOR THE EARLY DETECTION, MONITORING, AND MONDINO ORD Emerging Technologies and REHABILITATION OF COGNITIVE IMPAIRMENT Training in s Optimization of diagnostic and clinical management of patients with combined chronic obstructive pulmonary and ischemic heart disease. MAUGERI CLI ORD Cardiovascular and Respiratory Identification in patients with gastric cancer of molecular events predictive of peritoneal carcinomatosis and of the response to heated intraperitoneal chemotherapy. SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney and Urological Systems Pagina 316 di 332

317 CLINICAL AND LOGICAL INVESTIGATIONS IN PATIENTS WITH PRIMARY PLASMA CELL LEUKEMIA RECEIVING A TRIPLE COMBINATION OF BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE AS FIRST LINE TREATMENT Virus host interaction in Influenza A and Hepacivirus infections: ecological and molecular studies B cell specific nanoparticles as a vehicle for innovative in vivo drug delivery in p53 dependent chemoresistant chronic lymphocytic leukemia Epitope mapping of Pru p 3 with multiple antigen or linear peptides: new approaches for the diagnosis and follow up of patients with severe IgE mediated reactions to food MARKERS OF ENDOTHELIAL PROLIFERATION IN BREAST AND COLORECTAL CANCERS: A NEW PROSPECTIVE FOR TARGET THERAPY. CROB CLI ORD Oncology Istituto Superiore di Sanita' ORD Veterinary C.R.O. AVIANO ORD Oncology Toscana ORD Immunology 24, Sicilia CLI ORD Oncology 2 24, Optimization of the number of fractions in hypofractionated external beam radiation therapy: suggestions from fitting a reoxygenationincluding TCP model to in vivo and to clinical data. Veneto ORD Oncology 2 24, Molecular profiling of squamous cell carcinomas of the head and neck: evaluation of diagnostic, prognostic and therapeutic implications Istituto Superiore di Sanita' ORD Oncology 2 24, Oxidative stress and apoptosis defects in naive Kawasaki disease patients OSPEDALE BAMBINO GESU' CLI ORD Vascular and 24, Hematology Pagina 317 di 332

318 Development of an expert system software for reporting antimicrobial resistance assays results through a decision making process and management of antimicrobial resistance data. Istituto Zooprofilattico Sperimentale della Sardegna CLI ORD Veterinary 24, IntraOperative Imaging Technologies (IOIT): supporting decision making process in the Italian National Health Care System (NHS) Agenzia per i Servizi Sanitari Regionali CLI ORD Surgical, Biomedical Imaging, and Bioengineering 24, Targeting MicroRNA profile in cancer associated angiogenesis: new therapeutical and prognostic tools. Characterization of extrapyramidal features in mitochondrial disorders Efficacy and safety of early and intensive rehabilitative interventions in patients with stroke. A randomized controlled trial Pathogenicity, virulence and antibiotic resistance mechanisms of Multi Drug Resistant (MDR) Gram negative bacteria: impact on Rehabilithation Facility patients and on infection control strategies. THE SIGNATURE OF TRANSCRIPTION FACTORS INVOLVED IN AGGRESSIVE OVARIAN CANCER Abruzzo ORD Oncology 2 24, S.CAMILLO CLI ORD Brain Disorders and 24, SANTA LUCIA CLI ORD Brain Disorders and 24, MAUGERI ORD Infectious Diseases 24, and Microbiology Molise ORD Oncology 2 24, A RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFECTIVENESS OF AN INTEGRATE TRAINING IN PRIMARY CAREGIVERS AND IMMIGRANT PAID CAREGIVERS WHO CARE FOR PATIENTS WITH DEMENTIA FATEBENEFRATELLI CLI ORD Healthcare Delivery 24, and Methodologies Pagina 318 di 332

319 Study on relation between protein aggregation and mitochondrial dysfunction: an effort to find new targets for the diagnosis and therapy of neurodegenerative deseases. Istituto Zooprofilattico Sperimentale della Sicilia ORD Brain Disorders and 24, Effects of different radiation schedules on an immortalized human neural progenitor cell line grown as monolayers or spheroids. DETECTION OF C KIT ; BRAF AND N RAS MUTATION IN NAIL MELANOMA Emilia Romagna ORD Oncology 2 24, Emilia Romagna ORD Genes, Genomes 24, and Genetics Antimicrobial resistance and Zoonoses in Wildlife: Emerging Issues. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 24, Optimizing the combined use of electrical stimulation and dopaminergic drugs in temporal and spatial aspects of action neuro rehabilitation DETECTION OF ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTION IN A POPULATION OF OBESE SUBJECTS. THE ROLE OF NATRIURETIC PEPTIDE AND ECHOCARDIOGRAPHY: STUDIO PROBE OBESITY Application of digital images acquired by computed tomographyand magnetic resonance in forensic medicine: virtual autopsy Ex vivo generation of human red blood cells from umbilical cord stem cells Lazio CLI EST Brain Disorders and 24, Toscana CLI ORD Cardiovascular and Respiratory NEUROLESI CLI ORD Surgical, Biomedical Imaging, and Bioengineering Emilia Romagna ORD Vascular and Hematology Pagina 319 di 332

320 Endoscopic treatment of obesity and type 2 diabetes by endoluminal device (Endobarrier): a prospective study SAN RAFFAELE MONTE TABOR CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive In vitro and in vivo evaluation of the mechanisms of NK cells interaction with Acute Myeloid Leukemia cells. Role of peritoneal dialysis in the treatment of refractory heart failure Pain in post surgical hip and knee rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain free therapeutic algorithm. MECOLECULAR PROFILING OF NORMAL AND CANCER HUMAN PROSTATE STEM CELLS Developing Gold Nanoparticles for detection of circulating tumor cells in early diagnosed breast cancer patients Cognitive stimulation versus music therapy in patients with cognitive impairment secondary to multiple sclerosis or brain tumor Cluster randomized trial to assess the effectiveness of a population based educational campaign on stroke symptom recognition in reducing pre hospital delay. Characterization of molecular pathways predicting the responsiveness to multikinase inhibitors in renal cancer. Emilia Romagna ORD Immunology Puglia CLI ORD Cardiovascular and Respiratory DON GNOCCHI CLI ORD Musculoskeletal, Oral and Skin Sicilia ORD Oncology 1 Basic MAUGERI ORD Biological Chemistry and Macromolecular Biophysics CARLO BESTA CLI ORD Brain Disorders and Emilia Romagna CLI ORD Healthcare Delivery and Methodologies Veneto ORD Genes, Genomes and Genetics Pagina 320 di 332

321 Modeling neurodegenerative disease in mice by overexpression of beta catenin in T cells: toward discovery of the novel mechanisms and therapies for amyotrophic lateral sclerosis CLINICAL AND SOCIAL GOVERNANCE OF MIGRANTS OF MEDITERRANEAN Governance: New Healthcare Delivery Performance Scorecard THE GENETICS OF THE INTERPLAY BETWEEN PRO SURVIVING AND REGULATOR OF THE GLUTAMATERGIC SYSTEM AS A BASIS OF ANTIDEPRESSANT RESPONSE Affective symptoms dimensions and treatment outcome in unipolar and bipolar depression. NEUROLESI ORD Brain Disorders and Sicilia CLI ORD Healthcare Delivery and Methodologies Molise CLI ORD Healthcare Delivery and Methodologies Emilia Romagna ORD Genes, Genomes and Genetics Sicilia CLI ORD Brain Disorders and 25, The role of oxytocin in anxiety disorders FATEBENEFRATELLI ORD Brain Disorders and 25, ESTABLISHING THE IN VIVO THRESHOLD FOR AMYLOID DEPOSITION IN PRODROMAL TYPICAL AND ATYPICAL ALZHEIMER DISEASE T cell Lymphoblastic Lymphoma and T cell Acute Lymphoblastic Leukemia: NOTCH1 alterations as a new target for an innovative treatment strategy DNA Bank in IRCCS San Donato Group to Study the Correlation between Genotypic and Phenotypic Pictures in the Metabolic Syndrome and in Type 2 Diabetes Toscana CLI ORD Brain Disorders and 25, Emilia Romagna CLI ORD Oncology 2 25, SAN DONATO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 25, Pagina 321 di 332

322 IATRIS neuroscience: a critical reassessment of preclinical studies in neurologic diseases. Expression and functions of Toll like receptors in pediatirc acute leukemia cells and leukemia initiating cells Istituto Superiore di Sanita' ORD Brain Disorders and 25, GASLINI ORD Immunology 25, Taxi Doctor SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 25, and Methodologies Is there a causal relationship among serum ADMA levels, IMT, white matter hyperintesities and executive dysfunction? A Cross sectional study The Rorschach Test as a neuropsychological assessment tool Evaluation of Magnetic and Electromagnetic Fields Exposure for Workers in Magnetic Resonance Environments CPAP (CONTINUOUS POSITIVE AIRWAY PRESSURE) FOR SLEEP DISORDERS IN CHRONIC HEART FAILURE NEUROLESI CLI ORD Brain Disorders and NEUROLESI CLI ORD Brain Disorders and NEUROLESI ORD Healthcare Delivery and Methodologies Emilia Romagna CLI ORD Cardiovascular and Respiratory Screening for tuberculosis and tuberculosis infection in risk group: new tools for health surveillance Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Infectious Diseases and Microbiology Creation of the Sicilian Documentation System for safety, quality communication and development of local food products on domestic and international market Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary Pagina 322 di 332

323 Identification of biomarkers to be predictive of PASCALE ORD Immunology response to anti CTLA4 treatment in the peripheral blood and tissues of melanoma patients Ticks transmitting diseases in Sicily: early detection, diffusion and risk analysis of Tick borne diseases, with particular attention to Anaplasmosis. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary Monitoring of heavy metals and nanoparticles in fishes and babyfoods of animal origin Istituto Zooprofilattico Sperimentale della Sicilia ORD Risk, Prevention and Health Behavior Design, synthesis, biological and theoretical evaluation of new heterocycles as antitumour and antibacterial agents. Sicilia ORD Biological Chemistry and Macromolecular Biophysics EXPERIMENTAL AND CLINICAL USE OF STEM CELLS IN THE TREATMENT OF HEART FAILURE Sicilia ORD Cardiovascular and Respiratory Control of Feral Dog Populations by Immunocontraception Istituto Zooprofilattico Sperimentale del Lazio e della Toscana EST Veterinary 26, An improve of tumor regression with a cancer risk modulated radiochemotherapy in local advanced rectal cancer (LARC) can lead to avoid doing major surgery: a randomized phase II study. Study on polymorphisms within micro RNAbinding sites of CD86 in Umbrian population and risk of sporadic colorectal cancer. Regional network for diagnosis and treatment of early arthritis Emilia Romagna CLI ORD Oncology 2 26, Umbria ORD Oncology 1 Basic 26, Piemonte CLI ORD Musculoskeletal, 26, Oral and Skin Pagina 323 di 332

324 Multicentre prospective study on interventional endoscopic ultrasound complications The automatic visuospatial attentional component in Parkinson's disease: a pilot study Assessment framework of cortical plasticity following stroke Treatment of Kaposi s Sarcoma by Electrochemotherapy: and Virological evaluation Pharmacological target identification for high risk neuroblastoma therapy Effect of long term Physical Activity training on health: epigenetic and OMICs integrated approaches In vitro and in vivo Neuroblastoma models for predicting Voacamine dose response implementation and implications of 3D anatomical libraries in Radiation Oncology Pathogenesis of Multiple Sclerosis: role of Fas/FasLigand and TNFalfa/TNFR1 and TNFR2 systems in the apoptosis of T cells autoreactive to myelin Sicilia CLI ORD Oncology 2 26, S.CAMILLO CLI ORD Integrative, Functional, and Cognitive 26, SANTA LUCIA ORD Brain Disorders and 26, SAN GALLICANO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 26, FATEBENEFRATELLI ORD Oncology 2 26, SDN EST Interdisciplinary 26, Molecular and Training Istituto Superiore di Sanita' ORD Oncology 2 26, Emilia Romagna ORD Oncology 2 26, NEUROLESI ORD Immunology 26, Pagina 324 di 332

325 Analysis of specific markers of mental health, after time by admissions to a hospital, for onset of psychiatric disorders in developmental age. Immunological properties of fetal stem cells retrieved from placenta and amniotic fluid Sicilia CLI ORD Biobehavioral and 26, Behavioral Processes Veneto EST Immunology 26, Title: Study on target therapies Impact in breast cancer patients on a wide area ofnorthern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma,Piacenza Tumour Registry ARCISPEDALE CLI ORD Oncology Development of autoantibody signatures as powerful diagnostic/prognostic biomarkers of inflammatory disorders of the nervous system A Pilot study for implementation of regional guidelines for integrated management of heart failure in ligurian population between hospital and territory ( P.O.N.T.E ). Development of nanoparticles based contrast agents for enhanced biomedical imaging Induced Pluripotent Stem Cells for neurodegenerative disease Suppressing bladder cancer stem cell function by aldehyde dehydrogenase inhibition with disulfiram: phase II clinical trial with biomarker evaluation of clinical response Toscana ORD Immunology Liguria CLI ORD Healthcare Delivery and Methodologies NEUROLESI ORD Bioengineering and Technologies Abruzzo ORD Emerging Technologies and Training in s Emilia Romagna CLI ORD Oncology Correlation between activity and genetic polymorphisms of the NF kb gene and erythroid response to iron chelation therapy in patients with myelodysplastic syndrome CROB ORD Oncology Pagina 325 di 332

326 Evaluation of circulating endothelial cells as a biomarker of endothelial damage in patients undergoing allogeneic stem cells transplantation (allobmt): correlation with graft versus host disease (GVHD) onset. Lombardia ORD Vascular and Hematology Evaluation of Brucella spp. strains spread in Sicily Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary LIMIT LOAD AND THE MECHANICAL RESPONSE TO THE PHYSIOTHERAPY TREATMENT OF THE NEURO MUSCULAR DEFICIENCY IDENTIFICATION AND ANALYSIS OF MOLECULAR MECHANISM IN SPORADIC AND FAMILIAL FORMS OF CCM. Addictive Disorders in Parkinson s disease: a multidisciplinary approach to understand and prevent The effect of migration waves on rare diseases incidence at birth in Friuli Venezia Giulia Region and comparison of the frequency of perinatal outcomes in children born from Italian, foreign and interracial couples in three Northern Italian Regions. How to personalize the classic and atypical antipsychotic therapy in elderly patients affected by dementia: a pharmacogenetic study. Mechanisms of T lymphocyte immunomodulation: role of IL 27 in the Th1/Tc1 induction in chronic obstructive pulmonary disease (COPD) MAUGERI CLI ORD Bioengineering and Technologies NEUROLESI ORD Brain Disorders and Istituto Superiore di Sanita' ORD Brain Disorders and 27,5 0 Friuli Venezia Giulia CLI ORD Population 27, and Epidemiology Piemonte ORD Brain Disorders and 27, MAUGERI ORD Cardiovascular and 27, Respiratory Pagina 326 di 332

327 ACCEPTANCE CRITERIA FOR THE EVALUATION OF RADIOTHERAPY PLANNING GLYCOGEN STORAGE DISEASE TYPE I AND ATHEROSCLEROSIS. Thermalism role in the management of arthralgia in women treated with aromatase inhibitors Emilia Romagna ORD Oncology 2 27, Friuli Venezia Giulia CLI ORD Vascular and Hematology Piemonte CLI ORD Oncology Value of MR combined Imaging in assessment of early response to neoadjuvant theraphy in Locally Advanced Breast Cancer PASCALE ORD Oncology Alpha Synuclein as a possible predictive and prognostic marker for Parkinson's Disease Evaluation of recidive risk after resection in hepatocellular carcinoma using a molecular profiling signatures. A New Cross Platform Multi Signature Classifier Approach To Predict Neuroblastoma Patients Outcome TREATMENT OF EARLY STAGE (I II) OROPHARYNGEAL CANCER WITH TRANSORAL ROBOTIC SURGERY VERSUS ESCLUSIVE RADIOTHERAPY: PROSPECTIVE MULTICENTER RANDOMIZED STUDY. Randomized controlled clinical trial comparing Y90 TARE (Transarterial Radioembolisation with Y90) to sorafenib in the treatment of advanced HCC complicated with portal vein thrombosis Istituto Superiore di Sanita' ORD Brain Disorders and Emilia Romagna ORD Oncology 2 28, GASLINI CLI ORD Oncology 2 28, I.E.O. CLI ORD Oncology 2 28, Emilia Romagna CLI ORD Digestive, Kidney 28, and Urological Systems Pagina 327 di 332

328 Cognitive, genetic and structural features in affective and schizophrenic spectrum disorders. Adjuvant therapy for resected stage III N1 melanoma patients A MODEL TO EVALUATE EFFECTIVENESS AND APPROPRIATENESS OF DRUGS USING THE ITALIAN RFOM REGISTRY Fibrosis, regeneration and cancer: links, molecular pathways and potential role of microvesicles SAFETY ANALYSIS OF RADIOPHARMACEUTICALS PRODUCTION PROCEDURES BY USING ADVANCED ACCELERATOR APPLICATIONS Develop of new whole body Dosemeter for measuring ionizing Radiation to Operators in medical practice and of STErilizable wrist dosemeter (DROSTE) CD39 and CD73 as potential markers to identify women susceptible to recurrent pregnancy loss Blood brain barrier alteration and oxidative stress in neurodegenerative diseases: benefits of melatonin administration Veneto CLI ORD Brain Disorders and Istituto Superiore di Sanita' CLI EST Oncology I. O. V. CLI ORD Healthcare Delivery and Methodologies Istituto Superiore di Sanita' ORD Cell Biology Sicilia CLI ORD Healthcare Delivery and Methodologies Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering Marche ORD Genes, Genomes and Genetics FATEBENEFRATELLI ORD Brain Disorders and The nuclear factor HMGA1: a novel gene for early diagnosis and prognosis of type 2 diabetes mellitus Calabria ORD Genes, Genomes and Genetics Molecular profiles in Male Breast Cancer (MBC) Sicilia ORD Oncology Pagina 328 di 332

329 Role of T cell subpopulations in the pathogenesis of Multiple Sclerosis A single cross over study to evaluate the effect of bethametasone on acute attacks in episodic ataxia patients. Realization of a complete model of the cardiocirculatory system, by means of hybrid modelling, for testing implant strategies of prosthetic devices. An endoscopic information system for the achievement and the distribution of clinical images and video associated to the surgical procedures Analysis of the correlation between semen parameters and the levels of retinol, tocopherol and carotenoids in human seminal plasma and blood Transplantation of kidneys with small renal tumours: a new strategy for expanding the kidney donor pool NEUROLESI ORD Immunology SANTA LUCIA CLI ORD Brain Disorders and 29, Istituto Superiore di Sanita' ORD Bioengineering 29, and Technologies Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering 29, Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 30 0 Emilia Romagna ORD Digestive, Kidney and Urological Systems Genotypes of Toxoplasma gondii their phylogeny, pathogenicity and transmission among wildlife, livestock and humans. Eating ectoparasites is an additional factor of risk for infection? Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary Creation of a disease risk model by the identification of genes underling food related traits and their relationship with health status in two isolated populations from Italy. BURLO GAROFALO ORD Genes, Genomes and Genetics Pagina 329 di 332

330 Prevention and treatment of atherosclerotic vascular disease in people living in the same geographical area. SUICIDE ATTEMPTS: FROM EPIDEMIOLOGY TO CLINICAL DIAGNOSIS A GROUP COGNITIVE/BEHAVIOURAL INTERVENTION FOR METABOLIC SYNDROME RISK REDUCTION, IN PATIENTS TREATED WITH ATYPICAL ANTIPSYCOTICS Development of Citotoxic T Lymphocytes (CTL) active against Neuroblastoma: investigation of an immunotherapy approach, production from laboratory to clinic in compliance with Good Manufacturing Practice (GMP) Veneto CLI ORD Vascular and Hematology Emilia Romagna CLI ORD Risk, Prevention 30, and Health Behavior Emilia Romagna ORD Biobehavioral and 30, Behavioral Processes Emilia Romagna ORD Oncology 2 30, CONTROL AND MANAGEMENT OF LOGICAL FOOD RISKS: SETUP AND APPLICATION OF INNOVATING MODELS BASED ON TECHNOLOGICAL METHODS FOR DETECTION OF VIRUS, PARASITES AND BACTERIA Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 30, Novel shuttling hallmarks for bone pathologies GALEAZZI ORD Musculoskeletal, Oral and Skin Establishing a New Drugs Development Programme at the Istituto Nazionale Tumori Fondazione G. Pascale Normal pressure hydrocephalus and parkinsonism: integration of surgical and medical treatment. PASCALE CLI ORD Oncology CARLO BESTA CLI ORD Brain Disorders and 31, Pagina 330 di 332

331 Hospital malnutrition Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive Preliminary Study on Bone Tissue Regeneration in Massive Loss of Substance in MusculoSkeletal Oncology Evaluation of a novel tumor markers panel in the diagnosis of occult ovarian and tubal cancers in BRCA1 and BRCA 2 mutated women undergoing bilateral prophylactic salpingo oophorectomy: A prospective observational study ROLE OF micrornas IN THE PATHOGENESIS OF BARRETT S ESOPHAGOUS Screening of the genetic alterations in patients affected by high myopia Title: Preclinical evaluation of targeting recipient antigen presenting cells before allogeneic HSCT for the prevention of acute GVHD Investigations on the multifaceted role of Enhancer of Zeste 2 (EZH2) in glioblastoma biology Role of the master transcription factor Yin Yang 1 (YY1) in the diagnosis of bone lesions REGINA ELENA ORD Musculoskeletal, Oral and Skin I.E.O. CLI ORD Oncology 2 32, Sicilia ORD Oncology Veneto ORD Genes, Genomes 33, and Genetics Emilia Romagna ORD Immunology CARLO BESTA EST Oncology 1 Basic SDN CLI ORD Oncology (3) Pagina 331 di 332

332 LEGENDA : NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal Bando NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso Bando anche se in altra sezione NOTA 4 = Progetto Giovane Ricercatore Estero Finanziato in quanto con punteggio uguale od inferiore a 8,5 score Limite Finanziamento GR NOTA 5 = Progetto Finanziato per riserva Veterinaria/Sicurezza Alimentare Pagina 332 di 332