Ministero della Salute

Transcription

1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA Elenco Progetti Ordinari Presentati Kinetochore spindle binding as a new anticancer drug target. I.E.O. De Wulf Peter Arthur Oncology 2 Drug Discovery and Molecular Pharmacology DMP Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis HUMANITAS Invernizzi Pietro Immunology Hypersensitivity, Autoimmune, and Immune Role of Chromatin Remodeling in Epigenetic Cell Memory SANTA LUCIA Corona Davide Genes, Genomes and Genetics Molecular Genetics MGA Role of local synthesis and of systemic administration of Brain Derived Neurotrophic Factor (BDNF) in the striatum of the murine model of Huntington s disease. SANTA LUCIA Fusco Francesca Roma Brain Disorders and and CNN Prognostic role of melanoma follow upa prospective randomised study I.E.O. TESTORI ALESSANDRO CLI Oncology 2 Oncology CONC Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresistance Veneto mocellin simone Oncology 2 Cancer Biomarkers CBSS Omic's in Blastocoele Emilia Romagna Palini Simone Endocrinology, Metabolism, Nutrition and Reproductive Sciences Reproductive Sciences Small Business SEP EMNR E11 B Pagina 1 di 167

2 Neurophysiological approach to evaluate cerebrocerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA Molinari Marco CLI Brain Disorders and and CNN Mechanisms of T lymphocyte immunomodulation: role of IL 27 in the Th1/Tc1 induction in chronic obstructive pulmonary disease (COPD) MAUGERI Di Stefano Antonino Cardiovascular and Lung Cellular, Molecular, And Immunobiology LCMI GENETIC MODULATION OF COELIAC DISEASE CASA SOLLIEVO SOFFERENZA GRANDONE ELVIRA Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration S.CAMILLO Agnati Luigi Francesco Brain Disorders and and CNN Sensitizing cancer stem cells driven glioma to radiotherapy via pharmacological inhibition of Ataxia Telangiectasia Mutated protein IRCCS AOU San Martino IST (Genova) Frosina Guido Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of low and intermediate risk prostate cancer Emilia Romagna frezza giovanni CLI Oncology 2 Radiation Therapeutics and Biology RTB Whole transcriptome changes induced by vaccineelicited immune responses in melanoma patients: providing the rationale for the development of dynamic antigen updating of dendritic cell vaccines Emilia Romagna Guidoboni Massimo Immunology Transplantation, Tolerance and Tumor Immunology TTT Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino IST (Genova) Romani Massimo Oncology 1 Basic Cancer Genetics CG IDENTIFICATION OF GENES REGULATING SKIN FIBROSIS IN SCLERODERMA ISTITUTO DERMOPATICO DELL'IMMACOLATA NAPOLITANO MONICA Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Pagina 2 di 167

3 Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening AUXOLOGICO Stramba Badial Marco CLI Healthcare Delivery and Community Level Health Promotion CLHP Mediterranean Dietary to prevent conversion of Mild Cognitive Impairment to Alzheimer Disease: a randomized trial. CARLO BESTA Morbin Michela CLI Brain Disorders and and CNN Virus host interaction in Influenza A and Hepacivirus infections: ecological and molecular studies Istituto Superiore di Sanita' DI TRANI LIVIA Veterinary Animal Health ANHE CPAP (CONTINUOUS POSITIVE AIRWAY PRESSURE) FOR SLEEP DISORDERS IN CHRONIC HEART FAILURE Emilia Romagna Lari Federico CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF RNA silencing of the Gene for the Augmenter of Liver Regeneration in Hepatocarcinogenesis in vivo. DE BELLIS Francavilla Antonio Oncology 1 Basic Tumor Cell Biology TCB Steroid myopathy: pathogenies and prevention MAUGERI Bottinelli Roberto Musculoskeletal, Oral and Skin Sciences A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Miniussi Carlo Biobehavioral and Behavioral Processes Skeletal Muscle Biology and Exercise Physiology SMEP Motor Function, Speech and Rehabilitation MFSR Epidemiology, Biomolecular Characterization, Phylogenetic Analysis, and Evaluation of Urine Testing Strategy for Diagnosis of Chlamydia and HPV Infections in Migrant Women with Limited Access to Health Care Lombardia Orlando Giovanna CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Pre clinical evaluation of safety and efficacy of intraarterial infusion of mesenchymal stems cells in experimental models of neurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Blandini Fabio Brain Disorders and and CNN Pharmacological enhancement of tumor cell death by soluble or membrane bound TRAIL and SMAC mimetics ISTITUTO TUMORI MILANO Delia Domenico Oncology 1 Basic Cancer Molecular Pathobiology CAMP Pagina 3 di 167

4 From diet to cancer: an integrated approach to study the complex path from visceral fat associated inflammation to colon cancer Istituto Superiore di Sanita' Gessani Sandra Immunology Innate Immunity And Inflammation III Identification of gender related differences in oxidative stress biomarkers associated with atherosclerotic disease progression Istituto Superiore di Sanita' Profumo Elisabetta Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Genetic and malformation risk associated with techniques of fertilization in vitro (IVF): a comparative prospective study of genetic and ultrasound analyses of fetuses conceived with IVF and spontaneously. BURLO GAROFALO D'Ottavio Giuseppina CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA Clementi Emilio Giuseppe Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Quantitative Advanced Imaging (PET/MRI) in the Surgery and Radiotherapy of High Grade Brain Tumours ARCISPEDALE IORI MAURO Oncology 2 Radiation Therapeutics and Biology RTB ADVANCED CLINICAL AND MOLECULAR EFFORTS IN HEREDITARY SPASTIC PARAPLEGIA STELLA MARIS Santorelli Filippo M. Brain Disorders and and CNN "Leading nanomedicine into the therapy for Leukodystrophies: nanoparticles overcoming the bloodbrain barrier to treat the mouse model of Krabbe Disease" BURLO GAROFALO Severini Giovanni Maria Molecular, Cellular, and Developmental Drug Discovery in the Nervous System ZRG1 MNPS MicroRNA replacement therapy for the treatment of Neuroblastoma Liguria Ponzoni Mirco Oncology 2 Developmental Therapeutics DT Role of IL 4 producing granulocytes in thymic stromal lymphopoietin dependent Th2 type inflammation in pancreatic cancer Protti Maria Pia Immunology Transplantation, Tolerance and Tumor Immunology TTT Pagina 4 di 167

5 The personalized antidepressant therapy: from the genetic to clinical impact Provincia autonoma Bolzano Conca Andreas Emerging Technologies and Training in s Pharmacology and Diagnostics for Neuropsychiatric Disorders and Neural Systems Small Business SBPD Host/Tumor Tailored Clock Chemotherapy: fighting cancer around the clock CASA SOLLIEVO SOFFERENZA Mazzoccoli Gianluigi Oncology 1 Basic Cancer Genetics CG Targeting epithelial to mesenchymal transition and chemoresistance mediated by endothelin 1 signaling in epithelial ovarian cancer REGINA ELENA Bagnato Anna Oncology 1 Basic Tumor Microenvironment TME Glycation/glycoxidation products in the pathogenesis of cardiovascular diseases: a search for new biomarkers of cardiovascular risk Istituto Superiore di Sanita' Riganò Rachele Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Pharmacogenetics in Psychiatry: genetic susceptibility to psychotropic drugs metabolism CASA SOLLIEVO SOFFERENZA Colaizzo Donatella Brain Disorders and Neuroplasticity and Neurotransmitters CNNT MiRNAs in Forebrain Neurogenesis Muzio Luca Biology of Development and Aging Development 2 DEV NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' Fattorini Lanfranco Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR GENETIC AND NEUROLOGICAL INFLUENCES ON RISK TAKING PROPENSITY Istituto Superiore di Sanita' Picardi Angelo Population Sciences and Epidemiology Behavioral Genetics and Epidemiology BGES The response to intestinal microbiota in peripheral blood and gut mucosa from patients with Crohn's Disease: from the definition of immune profiles to the development of induced pluripotent stem cells for pharmacologic studies. BURLO GAROFALO Tommasini Alberto CLI Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology GMPB Pagina 5 di 167

6 Epigenetic therapy of leukemic stem cells in acute myeloid leukemias. I.E.O. Minucci Saverio Oncology 1 Basic Tumor Cell Biology TCB Path to cure CML and Ph+ leukemias Emilia Romagna Martinelli Giovanni CLI Oncology 2 Oncology CONC B7.1 on podocytes: a new therapeutic target for diabetic nephropathy Fiorina Paolo Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK Identification of a multi SNP profiling to predict metabolic syndrome in children OSPEDALE BAMBINO GESU' Nobili Valerio CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Molecular determinants of immune evasion in childhood acute leukemia. OSPEDALE BAMBINO GESU' Rutella Sergio Immunology Transplantation, Tolerance and Tumor Immunology TTT Natural Chemistry and Physical Energy to Optimize Stem Cell Therapy of Vascular Diseases Emilia Romagna Ventura Carlo Vascular and Hematology Vascular Cell and Molecular Biology VCMB Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' PUTIGNANI LORENZA Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP In vivo identification of molecular determinants critical to the metastatic process in melanoma I.E.O. Lanfrancone Luisa Oncology 1 Basic Tumor Cell Biology TCB Coronary arteriogenesis with combined pharmacological (dipyridamole and heparin) therapy Toscana Bolognese Leonardo CLI Cardiovascular and Myocardial Ischemia and Metabolism MIM Insight into molecular events involved in the cooperation between bcl 2/bcl xl and hypoxia in the regulation of tumor progression and angiogenesis REGINA ELENA Del Bufalo Donatella Oncology 1 Basic Tumor Progression and Metastasis TPM2 Pagina 6 di 167

7 Non invasive diagnosis on non alcoholic steatohepatitis and of significant/severe fibrosis among patients with non alcoholic fatty liver disease. Sicilia CRAXI' ANTONIO CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG SENESCENCE ASSOCIATED micrornas (SAmiRs) IN CELLULAR SENESCENCE AND ORGANISMAL AGING SDN CIMINO FILIBERTO Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Redox dysfunctions in autoinflammatory syndromes. Role in disease course, novel therapeutic approaches IRCCS AOU San Martino IST (Genova) Rubartelli Anna Immunology Innate Immunity And Inflammation III Evaluation of the therapeutic role of mesenchimal stromal cells in a murine model of systemic lupus erythematosus. Toscana Mosca Marta Immunology Hypersensitivity, Autoimmune, and Immune ARTEMIS (Augmented Realism in Teleconsulting and Education in MinimallyInvasive Surgery) Toscana Ferrari Mauro Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ZRCM Effect of proteasome and VEGF receptor inhibitors on NKG2D ligand expression on hepatocellular carcinoma cells: implications for immunotherapy of liver cancer. SAN MATTEO Mondelli Mario Umberto Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Induced Pluripotent Stem Cells for neurodegenerative disease Abruzzo Desideri Giovanbattista Emerging Technologies and Training in s Neurotechnology NT Realization of a complete model of the cardiocirculatory system, by means of hybrid modelling, for testing implant strategies of prosthetic devices. Istituto Superiore di Sanita' D'Avenio Giuseppe Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems MABS Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE Barcellini Wilma CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 7 di 167

8 Human Mesenchymal Stem Cells as site regulated medicinal cells stimulating endogenous repair mechanisms in tissue injury IRCCS AOU San Martino IST (Genova) Cancedda Ranieri Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE ESTABLISHMENT OF A SENIOR EMERGENCY ROOM FOR FRAIL ELDERLY AND PATIENTS WITH DEMENTIA Emilia Romagna colantoni alessandra CLI Healthcare Delivery and Health Services Organization and Delivery HSOD What is better for the therapy of chronic inflammatory demyelinating polyneuropathy? Intravenous Immunoglobulins versus steroids and intravenous immunoglobulins versus sub cutaneous immunoglobulins: a nationwide cost utility study. Piemonte Cocito Dario CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying inherited thombophilias. A family study CASA SOLLIEVO SOFFERENZA Tiscia Giovanni Population Sciences and Epidemiology Social Sciences and Population Studies ZRSS Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Piemonte Porta Massimo CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) THE SIGNATURE OF TRANSCRIPTION FACTORS INVOLVED IN AGGRESSIVE OVARIAN CANCER Molise Scambia Giovanni Oncology 2 Cancer Biomarkers CBSS Caveolin 1, PTRF expression and function in Non Small Cell Lung Cancer. IRCCS AOU San Martino IST (Genova) Maggi Davide Carlo Oncology 1 Basic Tumor Cell Biology TCB PRE CLINICAL DEVELOPMENT OF A HUMAN MONOCLONAL ANTIBODY AGAINST FAS LIGAND FOR THE TREATMENT OF PEMPHIGUS Emilia Romagna Pincelli Carlo Immunology Hypersensitivity, Autoimmune, and Immune Pagina 8 di 167

9 Prospective study in premanifest Huntington disease mutation carriers: new clinical and neuroradiological assessment tools for long term follow up and early signs evaluation CARLO BESTA Mariotti Caterina CLI Brain Disorders and and CNN Patient specific Induced Pluripotent Stem Cells (ipscs) to model neurodegeneration and to test gene therapy approaches in Lysosomal Storage Disorders (LSDs). Gritti Angela Genes, Genomes and Genetics Gene Therapy and Inborn Errors GTIE Special Emphasis Panel Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration : role of genome instability associated with tau mutations CARLO BESTA Rossi Giacomina Brain Disorders and Cell Death in CDIN Identification and biological characterization of individuals at risk for hereditary colorectal tumors Emilia Romagna Ponz de Leon Maurizio Genes, Genomes and Genetics Molecular Genetics MGA The Italian National Program on Surveillance of Antiretroviral Treatment in Pregnancy Istituto Superiore di Sanita' Floridia Marco AIDS and Related Research AIDS Studies and Epidemiology ACE A therapeutic approach to Fragile X syndrome based on the pharmacology of Rho GTPases Istituto Superiore di Sanita' Diana Giovanni Brain Disorders and Developmental Brain Disorders DBD PARP 1 and PARP 2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors in cell lines and in vivo. Toscana Moroni Flavio Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Innate immune signaling networks in intestinal epithelial cells and their role in shaping T cell responses in inflammatory bowel diseases Istituto Superiore di Sanita' Conti Lucia Immunology Innate Immunity And Inflammation III Non cancer (atherosclerotic, neurocognitive, reproductive) health effects of chronic low dose radiation exposure in cardiac catheterization lab workers (the Healthy Cath Lab Study) Sicilia Capodanno Davide Francesc CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 9 di 167

10 Cytokine secretion phenotype of airway immune cells in inflammatory and infectious diseases of the human lung Toscana giulia freer Immunology Hypersensitivity, Autoimmune, and Immune Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' Malorni Walter CLI Oncology 1 Basic Cancer Molecular Pathobiology CAMP Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus Istituto Superiore di Sanita' Ortona Elena Immunology Hypersensitivity, Autoimmune, and Immune Multiple gene analysis in bronchoscopic specimens from patients with advanced non small cell lung cancer I.E.O. De Pas Tommaso Marti CLI Oncology 2 Cancer Biomarkers CBSS TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI Silvestris Francesco Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Novel markers based on autophagy proteins in Parkinson's disease NEUROMED RUGGIERI STEFANO CLI Brain Disorders and and CNN D.A.I.P.P. Assessment of influencing factors in diabetes incidence and progression in paediatric immigrant population Piemonte CERUTTI FRANCO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD A stem cell platform to identify adverse effects of toxicants: an integrated environmental analysis (food, air and water) MAUGERI Minoia Claudio Cardiovascular and Cardiovascular Differentiation and Development CDD Development, implementation and evaluation of a population based informational and educational package to improve knowledge on palliative care. A quasiexperimental study in the Liguria Region. IRCCS AOU San Martino IST (Genova) Beccaro Monica CLI Healthcare Delivery and Community Level Health Promotion CLHP Gene expression profile at the onset of severe cardiac failure:identification and validation of new biomarkers Liguria Zannini Lucio Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 10 di 167

11 Molecular biomarkers and cellular biosensors of neurodegeneration VALTORTA FLAVIA Brain Disorders and and CNN Whole exome resequencing in familial Neural Tube Defects GASLINI De Marco Patrizia Genes, Genomes and Genetics Genetics of Health and Disease GHD Macrophage polarization and HIV infection. A model of multiple restrictions of the virus life cycle. Poli Guido AIDS and Related Research AIDS Molecular and Cellular Biology AMCB REGENERATION OF SCAPHOID BONE DEFICIENCY BY USING AUTOLOGOUS EX VIVO EXPANDED, GMP GRADE, BONE MARROW MESENCHYMAL STEM CELLS Veneto KRAMPERA MAURO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS The effectiveness of music therapy on depression and on Quality of Life in patients with Amyotrophic Lateral Sclerosis and in post Stroke condition. MAUGERI Raglio Alfredo CLI Healthcare Delivery and Nursing Science: Adults and Older Adults NSAA Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell permeable peptides in preclinical models MAUGERI Rossi Daniela Maria C Brain Disorders and Cell Death in CDIN FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. Gabellini Davide Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Patient participation in Change of Shift Procedures. The Implementation of the Bedside handover for the improvement of nursing quality ARCISPEDALE Wildner Juergen CLI Healthcare Delivery and Nursing Science: Adults and Older Adults NSAA Autism Epilepsy: endophenotypic characterization and correlation with astrocyte neuron interaction defects. STELLA MARIS Sicca Federico Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD Pagina 11 di 167

12 Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Bonora Enzo CLI Population Sciences and Epidemiology Kidney, Nutrition, Obesity and Diabetes KNOD Array CGH analysis of copy number variation (CNV) in patients with Hemophilia A: possible relationship with FVIII inhibitor development CASA SOLLIEVO SOFFERENZA Favuzzi GIOVANNI Genes, Genomes and Genetics Molecular Genetics MGA Isolation and characterization of interferon gammaproducing myeloid cells from the bone marrow of Severe Aplastic Anemia patients (SAA) GASLINI Corcione Anna Vascular and Hematology Hematopoiesis HP Urinary FDG loss and measurement of standardized uptake value "SUV" IRCCS AOU San Martino IST (Genova) Sambuceti Gianmario Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ZRCM A multidisciplinary approach to study Frontotemporal lobar degeneration FATEBENEFRATELLI Benussi Luisa Genes, Genomes and Genetics Genetics of Health and Disease GHD In vivo analysis of the interactions between exogenouly administred mesenchymal stromal cells and primary acute leukemia cells or leukemia initiating cells growing in NOG mice: implications for selective delivery of anticancer drugs to leukemic niches GASLINI Vito Pistoia Oncology 1 Basic Tumor Microenvironment TME Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development Istituto Superiore di Sanita' Brescianini Sonia CLI Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions IRAP A study on molecular characteristics of the gp120 Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Istituto Superiore di Sanita' Butto' Stefano AIDS and Related Research AIDS Immunology and Pathogenesis AIP Pagina 12 di 167

13 Evaluation of oxidative stress and inflammation in blood as possible non invasive markers for progression of alcoholic liver disease. IRCCS AOU San Martino IST (Genova) Testino Gianni Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria ORLACCHIO ALDO Brain Disorders and Cell Death in CDIN Role of hypoxia in glioblastoma metabolism. Looking for new therapeutic strategies to counteract tumor progression and recurrencies Abruzzo Galzio Renato Oncology 1 Basic Tumor Cell Biology TCB Post genomic approach to heart failure in diabetic patients SAN DONATO Menicanti Lorenzo CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Caffeine as a potential therapeutic option for Alzheimer's disease. Istituto Superiore di Sanita' Popoli Patrizia Brain Disorders and and CNN Evaluation of Opisthorchis felineus metacercariae infectivity after fish fillets freezing at different timetemperature combinations. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana De Liberato Claudio Veterinary Food Safety FOSA Pathogenic mechanisms and animal models of hereditary neurodegenerative cerebellar diseases due to mitochondrial defects. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta BRUSCO ALFREDO Genes, Genomes and Genetics Genetics of Health and Disease GHD The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Emilia Romagna Di Gennaro Cristiana Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS GENOMIC VARIATION AND PROTEOMIC PROFILE IN NEONATAL BRONCOPULMONARY DYSPLASIA AND RESPIRATORY DISTRESS CLINICAL SPECTRUM Carrera Paola Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 13 di 167

14 Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia Muzio Marta Immunology Innate Immunity And Inflammation III Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice FATEBENEFRATELLI Ghidoni Roberta Brain Disorders and and CNN Role of IBtk, a B cell signalling regulator, in cancer development. Sudden sensorineural hearing loss: searching for new molecular markers. INNATE IMMUNE CELL RESPONSE TO HYPOXIC MICROENVIRONMENT: IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS FOR JUVENILE IDIOPATHIC ARTHRITIS Calabria Quinto Ileana Cell Biology Cellular Signaling and Regulatory Systems CSRS Emilia Romagna Aimoni Claudia Vascular and Hematology Hemostasis and Thrombosis HT GASLINI Bosco Maria Carla Immunology Hypersensitivity, Autoimmune, and Immune Producing ips cells: a biobank service for translational genetic research Liguria Coviello Domenico Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG NEW DRUGS FOR BONE MASS RECOVER IN OSTEOPOROTIC PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS (RA): CLINICAL/MEDICAL STUDY. Emilia Romagna MASCIA MARIA TERESA Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD EasyHIFU: simplified lesion localization for HIFU treatment Toscana Mosca Franco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology BMIT In vivo modeling glioblastoma to identify new therapeutic targets and assay a novel oncolytic therapy IRCCS AOU San Martino IST (Genova) Malatesta Paolo Oncology 1 Basic Molecular Oncogenesis MONC Pagina 14 di 167

15 Biological markers in bone metastases from prostate cancer: evaluation of live and apoptotic Circulating (CTC) and Disseminated tumor cells (DTC) in patients undergoing chemotherapy and correlation with tumor response and bone turnover rate. I. O. V. BASSO UMBERTO CLI Oncology 2 Cancer Biomarkers CBSS The role of CLIC1 (Chloride channel 1) in the tumorigenicity of glioblastoma cancer stem cells I.E.O. Pelicci Giuliana Oncology 1 Basic Tumor Cell Biology TCB NUTRIGENOMICS IN PEDIATRIC INFLAMMATORY BOWEL DISEASES: A NEW BASIS FOR SERUM MARKERS DISCOVERY Veneto Plebani Mario Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG A marker of homeostatic failure locates seizure onset zone in surgically remediable focal epilepsies CARLO BESTA de Curtis Marco Brain Disorders and Acute Neural Injury and Epilepsy ANIE NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Lacal Pedro Miguel Brain Disorders and Neuroimmunology and Brain Tumors CNBT Relevance of host factors in the pathogenesis of HCVrelated lymphoproliferative disorders Toscana ZIGNEGO ANNA LINDA Oncology 1 Basic Cancer Etiology CE Role of Dbl in epithelial cell transformation: identification of new therapeutic targets for carcinomas Liguria Vanni Cristina Oncology 1 Basic Tumor Microenvironment TME Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Scarpini Elio Brain Disorders and and CNN SAFETY AND TOLERABILITY OF SECOND GENERATION ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROACTIVE/PROSPECTIVE PHARMACHOVIGILANCE STUDY MEDEA Nobile Maria CLI Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD Pagina 15 di 167

16 Mechanisms of mood control by inflammatory cytokines in Multiple Sclerosis. SANTA LUCIA CENTONZE DIEGO CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Gender and age related differences in motility and permeability responses in human colon: role of estrogens. DE BELLIS Maselli Maria Antoniett Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Improving quality of research: a complex intervention trial Emilia Romagna Caminiti Caterina CLI Healthcare Delivery and Biostatistical Methods and Research Design BMRD Monitoring allogeneic Hematopoietic stem cells transplant patients for viral load and CMV drug resistance genotypes GASLINI Biassoni Roberto Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Next Generation Sequencing techniques open up new possibilities in the knowledge and diagnosis of hereditary arrhythmogenic diseases Piemonte Giustetto Carla Cardiovascular and and Integrative Cardiovascular Sciences CICS Human infection from exposure to norovirus: improving diagnostic techniques and correlation analysis between clinical cases and infected food. Developing a network among hospital units and IIZZSS in some Italian regions Istituto Zooprofilattico Sperimentale delle Venezie Arcangeli Giuseppe Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Characterization of new molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian cancers CROB Landriscina Matteo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pulmonary Rehabilitation in Lung Cancer surgical patients. SAN RAFFAELE PISANA Cesario Alfredo CLI Cardiovascular and Respiratory Integrative Biology and Research RIBT Pagina 16 di 167

17 The adenosine receptors: potential targets for diagnosis, prognosis and therapy of cancer Emilia Romagna degli Uberti Ettore Oncology 2 Cancer Biomarkers CBSS MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Cavallo Perin Paolo Cardiovascular and and Integrative Cardiovascular Sciences CICS Metabolic and cardiovascular risk in non obese and obese patients with obstructive sleep apnea: long term follow up Sicilia Bonsignore Maria Rosaria Population Sciences and Epidemiology Cardiovascular and Sleep Epidemiology CASE Development of an easily available Monte Carlo based tool to improve dose delivery accuracy in helical tomotherapy Istituto Superiore di Sanita' Caccia Barbara Oncology 2 Radiation Therapeutics and Biology RTB MZN, a new natural herbal compound to combat HIV infection Vicenzi Elisa AIDS and Related Research AIDS Discovery and Development of Therapeutics ADDT G15 expression in pancreatic cancer:its prognostic and diagnostic value as a clinical/molecular marker and as a pharmacological target Veneto Bassi Claudio Oncology 1 Basic Molecular Oncogenesis MONC Observational prospective study of pulmonary groundglass nodules: meaning and efficacy of CAD detection for neoplastic patients. I. O. V. Polverosi Roberta CLI Oncology 2 Oncology CONC Technological advancement in deep brain stimulation surgery for Parkinsonian patients: use of neuronavigated frameless system Sicilia Domenico Iacopino CLI Brain Disorders and and CNN Search for new mutations and polymorphisms of FSHR and LHR genes in hypergonadotropic hypogonadic patients without obvious testicular pathogenic noxa. Toscana Di Cairano Giovanni CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction CMIR Genetics of Hearing loss: from basic research to clinical applications BURLO GAROFALO Gasparini Paolo CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 17 di 167

18 Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Role of Calcium/Calmodulin dependent Kinase Kinase 2 in metabolic stress and inflammatory response Emilia Romagna Di Virgilio Francesco Immunology Transplantation, Tolerance and Tumor Immunology TTT SAN RAFFAELE PISANA RACIOPPI LUIGI Immunology Innate Immunity And Inflammation III Congenital malformations in domestic ruminant calves in southern Italy: a study of the main genetic, toxicological and infective causes Istituto Zooprofilattico Sperimentale del Mezzogiorno Fusco Giovanna Veterinary Animal Health ANHE HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana LUCONI MICHAELA Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer Calabria SCALA GIUSEPPE Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] CLINICAL AND PHARMACOLOGICAL EVALUATION OF TRABECTEDIN (T) IN BRCA MUTATION CARRIER AND BRCANESS PHENOTYPE OVARIAN CANCER PATIENTS ISTITUTO TUMORI MILANO LORUSSO DOMENICA CLI Oncology 2 Oncology CONC GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS.EFFECT OF MUTATIONS OF APOB AND ANGPTL3 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Emilia Romagna TARUGI PATRIZIA Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention of Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia Romagna Missale Gabriele Oncology 2 Developmental Therapeutics DT Pagina 18 di 167

19 Perinatal stress in human and non human offspring: a translational approach to study epigenetic impact on depression. Istituto Superiore di Sanita' Cirulli Francesca Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health MESH NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA. NEUROLESI cuzzocrea salvatore Molecular, Cellular, and Developmental Neurogenesis and Cell Fate NCF VENOUS THROMBOEMBOLISM IN FAMILIES WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE CLINICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY INVESTIGATION OF INDIVIDUALS WITH INHERITED THROM Lazio De Stefano Valerio CLI Population Sciences and Epidemiology Behavioral Genetics and Epidemiology BGES Cotransplantation of pancreatic islets and engineered third party human umbilical cord mesenchymal stem cells. A novel approach to increase graft survival and immune tolerance in type 1 diabetes patients Toscana Pistello Mauro Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO A Pharmacogenomic Approach to Retinal Neuroprotection in Age Related Macular Degeneration. Lazio Falsini Benedetto CLI Cell Biology Biology and Diseases of the Posterior Eye BDPE Eco epidemiology of M. bovis in a complex rural zoothenic system and identification of wild animals reservoirs Istituto Zooprofilattico Sperimentale della Sicilia Di Marco Lo Pr Vincenzo Veterinary Animal Health ANHE Assessing the effect of an intensive rehabilitation treatment(irt) on neurotrophic factors production in patients with Parkinson s disease MAUGERI Frazzitta Giuseppe Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Sp140 PHD finger as a potential target for chronic lymphocytic leukemia: a multidisciplinary approach Musco Giovanna Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function C MSFC Pagina 19 di 167

20 Corrective cardiac surgery in utero: a new frontier for the management of the unborn child and for perinatal medicine Toscana Murzi Bruno Cardiovascular and Cardiovascular Differentiation and Development CDD Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano Cortelazzo Sergio CLI Oncology 2 Cancer Biomarkers CBSS Cranioplasty and rehabilitation for brain injured patients Emilia Romagna Battistini Alberto CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Safety and efficacy of infusion of human adipose derived mesenchymal cells in experimental models of whole and partial liver transplantation in large size animals. Emilia Romagna Cescon Matteo Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP ESTABLISHING THE IN VIVO THRESHOLD FOR AMYLOID DEPOSITION IN PRODROMAL TYPICAL AND ATYPICAL ALZHEIMER DISEASE Toscana SORBI SANDRO CLI Brain Disorders and and CNN Development of an innovative strategy based on the use of lytic bacteriophages for an effective and safe treatment of irrigation and washing waters of crops Istituto Zooprofilattico Sperimentale del Mezzogiorno capuano federico Veterinary Food Safety FOSA Na+ Ca2+ exchanger 1 (NCX1) as new potential therapeutic target in the management of bacteriainduced heart hypertrophy and related complications Marche Amoroso Salvatore Cardiovascular and Electrical Signaling, Ion Transport, and Arrhythmias ESTA Exploiting the p53 p66shc signalling pathway to identify new molecular markers for the prevention of cancer and age related diseases I.E.O. Migliaccio Enrica Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD A phase III study (IRMA3): breast cancer at low risk of local recurrence: irradiation and accelerated partial threedimensional conformal radiotherapy (3D CRT) versus standard radiotherapy and intraoperative radiotherapy(iort) versus standard radiotherapy Emilia Romagna panzini ilaria CLI Oncology 2 Radiation Therapeutics and Biology RTB Pagina 20 di 167

21 Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. OASI MARIA S.S. Salemi Michele Interdisciplinary Molecular Sciences and Training Fellowship: Genes, Genomes, and Genetics F MicroRNA regulation of cellular signalling pathways: Identification of prognostic and therapeutic biomarkers in high risk soft tissue sarcoma patients RIZZOLI Picci Piero Oncology 1 Basic Tumor Cell Biology TCB Epigenetic profiles of prognostic markers and therapeutic targets in non small cell lung cancer Emilia Romagna Calistri Daniele Oncology 1 Basic Cancer Molecular Pathobiology CAMP Role of autophagy in growth, progression and vascular mimicry of neuroblastoma GASLINI Pezzolo Annalisa Oncology 1 Basic Tumor Cell Biology TCB Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Toscana Battistini Stefania Brain Disorders and and CNN Role of PPAR (Peroxisome Proliferator Activated Receptors) alpha ligands in modulating allergen induced inflammatory and dysfunctional alterations of the airways. MAUGERI Candura Stefano Massim Cardiovascular and Lung Cellular, Molecular, And Immunobiology LCMI Mechanisms of the antitumor activity of HIV protease inhibitors treatment in HIV negative patients affected by classical Kaposi s sarcoma or cervical intraepithelial neoplasia Istituto Superiore di Sanita' Sgadari Cecilia Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Autoreactive T cell expansion profiles and mechanisms in patients with type I diabetes during beta cell replacement therapy Monti Paolo Immunology Transplantation, Tolerance and Tumor Immunology TTT Mechanisms and actions of Regorafenib, a new hepatoma (HCC) therapy DE BELLIS Carr Brian Irvin Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Novel predictive biomarkers for bevacizumab in colorectal cancer I. O. V. Indraccolo Stefano Oncology 2 Cancer Biomarkers CBSS Pagina 21 di 167

22 New prognostic markers and therapies for Merkel cell carcinoma SAN GALLICANO Donati Pietro Oncology 2 Developmental Therapeutics DT Integrated risk assessment for food safety emerging risks in sustainable farming systems (IRASF) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Brambilla Gianfranco Veterinary Food Safety FOSA Genome Remodeling in Luminal B and Ductal Triple Negative Breast Cancer Metastasis and Xenograft: Exome sequencing analysis for identification of driver pathways to overcome resistance I.E.O. Curigliano Giuseppe Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] CREATION OF A NATIONAL NETWORK FOR THE DIAGNOSIS OF MALIGNANT LYMPHOMAS Emilia Romagna Pileri Stefano CLI Oncology 2 Oncology CONC Sarcopenic obesity in hospitalized older persons: prevalence, associations with the geriatric syndrome of frailty, and effect on clinically relevant adverse health outcomes Emilia Romagna Forti Paola CLI Biology of Development and Aging Aging Systems and Geriatrics ASG Priority setting in healthcare: the case of home care program in Tuscany Region for heart failure patients Toscana Maccari Mauro CLI Healthcare Delivery and Health Services Organization and Delivery HSOD THE ROLE OF CALCIUM HOMEOSTASIS IN DEVELOPMENTAL ATAXIAS: genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ ATPase. OSPEDALE BAMBINO GESU' ZANNI GINEVRA Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC Enhancement of NKG2D ligands induced anti tumor response in Hodgkin s lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin metalloproteinase as possible therapeutic targets. Zocchi Maria Raffaella Immunology Transplantation, Tolerance and Tumor Immunology TTT Innovative Tool for Uni compartmental Knee Prostheses & Evolution of Guidelines. RIZZOLI Affatato Maria Ulderico S Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Pagina 22 di 167

23 Structural analysis of nucleophosmin as a target for acute myeloid leukemia treatment Abruzzo Federici Luca Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function C MSFC BACKGROUND VALUES OF ESSENTIAL TRACE ELEMENTS, TOXICANTS AND THEIR METABOLITES IN THE ITALIAN GENERAL POPULATION MAUGERI Turci Roberta Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Cutaneous sensory and autonomic innervation in early parkinsonism. A new tool to predict clinical evolution toward PD, MSA and PSP. MAUGERI NOLANO MARIA CLI Brain Disorders and and CNN Amelioration of diagnosis and therapy of steroid resistant nephrotic syndrome: a novel treatment approach by umbilical cord blood mesenchymal stem cells. MAGGIORE Edefonti Alberto CLI Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD GENERATION OF HUMAN MONOCLONAL ANTIBODIES INTERFERING WITH HIV TRANSCYTOSIS FOR THE PREVENTION OF MUCOSAL INFECTION Development of autoantibody signatures as powerful diagnostic/prognostic biomarkers of inflammatory disorders of the nervous system Istituto Superiore di Sanita' Flego Michela AIDS and Related Research AIDS Discovery and Development of Therapeutics ADDT Toscana Matà Sabrina Immunology Hypersensitivity, Autoimmune, and Immune GADD45beta cell permeable inhibitor peptide against cerebral ischemia Lombardia Borsello Tiziana Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Role of mir in the cytokine mediated regulation of gene expression in neoplastic B cells IRCCS AOU San Martino IST (Genova) Ferrini Silvano Oncology 1 Basic Tumor Microenvironment TME Study of the P2RX7 gene coding the purinergic P2X7 receptor for extracellular ATP, as a susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms identified in a cohort of ALS patients. SANTA LUCIA Volonte' Cinzia Brain Disorders and and CNN Pagina 23 di 167

24 Analysis of the effect of chemotherapeutic treatment on trastuzumab cytotoxic activity ISTITUTO TUMORI MILANO TAGLIABUE ELDA Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT LOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Ottaviani Donatella Veterinary Food Safety FOSA RNA sequencing for the detection of progressive HPV lesions REGINA ELENA Venuti Aldo Oncology 2 Cancer Biomarkers CBSS WHOLE EXOME SEQUENCING TO IMPROVE DIAGNOSTIC, PROGNOSTIC AND LOGICAL CHARACTERIZATION OF AML WITH NORMAL KARYOTYPE Umbria Falini Brunangelo Vascular and Hematology Hematopoiesis HP EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO De Paoli Paolo CLI Healthcare Delivery and Community Level Health Promotion CLHP Short and long term effects of ART in restoring intestinal mucosal immunity and reducing systemic immune activation in HIV infected patients. Istituto Superiore di Sanita' Andreotti Mauro AIDS and Related Research AIDS Immunology and Pathogenesis AIP Metabolic syndrome in the etiology and prognosis of hepatocellular carcinoma: a multicentre study. PASCALE Montella Maurizio CLI Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] Diurnal and Inter visit IOP fluctuations: a risk factor for conversion from ocular hypertension to primary openangle glaucoma? FATEBENEFRATELLI Quaranta Luciano CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM1 Pagina 24 di 167

25 Sirt1 and Sirt2 as targets for the manipulation of the proliferative processes associated to physiopathologic conditions of the skin ISTITUTO DERMOPATICO DELL'IMMACOLATA Albanesi Cristina Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS and biological studies on the increased thyroid cancer incidence in the volcanic area of Sicily. Sicilia Vigneri Riccardo CLI Oncology 2 Cancer Biomarkers CBSS Determinants of FDG uptake in Hodgkin disease IRCCS AOU San Martino IST (Genova) Morbelli Silivia Daniela CLI Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems MABS Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Angelucci Francesco Brain Disorders and Cell Death in CDIN A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Belletti Barbara Oncology 1 Basic Tumor Progression and Metastasis TPM CHARACTERIZATION OF NEW MOLECULAR MARKERS OF NEUROINFLAMMATION ASSOCIATED WITH ALZHEIMER'S DISEASE Sicilia IENTILE RICCARDO Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. NEUROLESI Riccardi Carlo Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Therapeutic targeting of HSP105 in human non Hodgkin lymphomas ISTITUTO TUMORI MILANO Di Nicola Massimo Oncology 2 Cancer Immunopathology and Immunotherapy CII NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES Istituto Superiore di Sanita' Federico Maurizio Bioengineering Sciences and Technologies Gene and Drug Delivery Systems GDD Molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy of Huntington disease Istituto Superiore di Sanita' Matarrese Paola Brain Disorders and Cell Death in CDIN Pagina 25 di 167

26 Exploiting the therapeutic and prognostic potential of micrornas in melanoma ISTITUTO DERMOPATICO DELL'IMMACOLATA D'Atri Stefania Oncology 2 Developmental Therapeutics DT effect of different therapeutic approaches for thyroidrelated orbitopathy (Graves' orbitopathy) Lazio MONTI SALVATORE CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA petrosini laura Biobehavioral and Behavioral Processes Biobehavioral Regulation, Learning and Ethology BRLE Deployment of the trigger tools within the electronic medical record to enhance error detection in Neonatal Intensive Care Units (NICU): a cluster, randomized trial Lombardia bellù roberto CLI Healthcare Delivery and Health Services Organization and Delivery HSOD GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT CLINICAL IMPLICATIONS SANTA LUCIA Persico Antonio Brain Disorders and Developmental Brain Disorders DBD Implementation of a fracture liaison service for the identification, evaluation and management of patients with osteoporotic fractures Toscana Marcocci Claudio CLI Healthcare Delivery and Health Services Organization and Delivery HSOD The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V Emilia Romagna Montini Giovanni CLI Digestive, Kidney and Urological Systems Urologic and Kidney Development and Genitourinary Diseases UKGD Leukocyte telomere length and risk of ischemic vascular disease in an Italian population. Molise Iacoviello Licia CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Evaluation of tolerability and efficacy of sorafenib treatment in patients with hepatocellular carcinoma. Sicilia Cammà Calogero CLI Oncology 2 Oncology CONC Pagina 26 di 167

27 Epidemiology of primary biliary cirrhosis in Lombardia: a validation and geographical clustering study HUMANITAS Podda Mauro CLI Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Optimization of diagnostic and clinical management of patients with combined chronic obstructive pulmonary and ischemic heart disease. MAUGERI Sarzi Braga Simona CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Prognostic utility of biological indicators in human colorectal cancer: the chemokine axis CX3CL1/CX3CR1 HUMANITAS Allavena Paola Oncology 1 Basic Tumor Progression and Metastasis TPM COMBINATORIAL IMMUNOLOGICAL AND NANOPARTICLE MEDIATED TARGETING OF THE EARLY STEPS OF THE METASTATIC DISEASE C.R.O. AVIANO PERRIS Roberto Oncology 1 Basic Tumor Progression and Metastasis TPM Assessment of the role of image guided radiotherapy (IGRT) in the treatment of head and neck cancers. A randomized phase III study of chemo radiation for stage III IVa oropharynx cancers: IGRT Intensity Modulated Radiotherapy (IMRT) with dose fraction esc ARCISPEDALE iotti cinzia CLI Oncology 2 Radiation Therapeutics and Biology RTB Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Sicilia Di Marco Vito CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP TOOLS FOR THE IMPROVEMENT OF ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES: AN INTERVENTION STUDY DON GNOCCHI Sofi Francesco CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation Piemonte Camussi Giovanni Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK Effects of ALR administration, a physiological antiapoptotic and anti oxidative molecule, on Parkinson's Disease transgenic mice during the progression of the disease. DE BELLIS PORCELLI PIETRO Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Pagina 27 di 167

28 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR SENTINELS FOR INFECTIOUS DISEASES? Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Acutis Pier Luigi Veterinary Animal Health ANHE Pathogenesis of congenital human cytomegalovirus infection SAN MATTEO Gerna Giuseppe Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Complex Interventions at Work: comparative analysis of case studies on implementation of process oriented organization of hospital care in community and teaching hospitals Emilia Romagna BALLINI LUCIANA CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. REGINA ELENA Piaggio Giulia Oncology 1 Basic Molecular Oncogenesis MONC Analysis of macrophage and neutrophil subpopulations in the vascular remodelling occurring in HCC genesis and progression. Implications for early diagnosis, prognosis and therapy. HUMANITAS Roncalli Massimo Oncology 2 Cancer Biomarkers CBSS Possible role of injured vascular cell derived microvesicles on pericyte vessel destabilization. Piemonte Beltramo Elena Oncology 1 Basic Tumor Progression and Metastasis TPM Development and assesment of a regional palliative care network. The Ligurian Palliative Care Demonstration Project. IRCCS AOU San Martino IST (Genova) Costantini Massimo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Paraganglioma syndrome associated with succinate dehydrogenase defects: toward the discovery of biomarkers and novel pharmacological therapies I. O. V. opocher giuseppe Oncology 1 Basic Tumor Cell Biology TCB Study of cerebral glucose metabolism by means of positron emission tomography (PET) in psoriatic patients with and without depression major before and after effective anti psoriatic therapies SAN GALLICANO Bonifati Claudio Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Pagina 28 di 167

29 Hypothesis driven gene candidate study of copper involvement in the pathogenesis of Alzheimer s disease: detection of sequence changes, haplotype profile of ATP7B gene and their molecular and functional aspects SAN RAFFAELE PISANA Cassetta Emanuele CLI Brain Disorders and and CNN Multicenter,Italian,randomized,open label,parallelgroup, non inferiority phase III clinical trial comparing cisplatin 5Fluorouracil cetuximab vs. carboplatinpaclitaxel cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck Lombardia Ferrari Daris CLI Oncology 2 Oncology CONC MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. REGINA ELENA Verdina Alessandra Oncology 1 Basic Tumor Microenvironment TME Aphasia. Theory for therapy. Therapy for theory. S.CAMILLO Semenza Carlo CLI Brain Disorders and and CNN Effect of eyes covering on variations of melatonin secretion, electroencephalographic pattern and outcome in patients with severe neurological damage. Emilia Romagna VOLPI ANNALISA Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Dissecting the CLL lipidome in search for novel prognostic markers and targets for tailored therapy Bachi Angela Oncology 2 Cancer Biomarkers CBSS Identification and pathways to care of children with complex or chronic health conditions and special health care needs Emilia Romagna Faldella Giacomo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Vg9Vd2 T cells in combination with zoledronate as novel immunotherapeutic approach for human neuroblastoma GASLINI Prigione Ignazia Oncology 2 Cancer Immunopathology and Immunotherapy CII Pagina 29 di 167

30 Oxidative stress and microrna 125b : from molecular mechanisms to therapeutic implications in Hailey Hailey disease Istituto Superiore di Sanita' Magrelli Armando Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Hepatitis C virus (HCV) infection beyond the liver: bone and cardiovascular manifestations. Sicilia FIORE CARMELO CLI Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Di Rienzo Marco Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD Malignancy and invasiveness molecular determinants in oro pharyngeal squamous cell carcinomas. REGINA ELENA De Marco Federico Oncology 1 Basic Tumor Cell Biology TCB Pentraxin 3 as a predictive biomarker of hemorrhagic transformation following acute stroke NEUROMED Vecchione Carmine CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Efficacy of re treatment with anti TNF biologics in patients with psoriasis who have been previously treated with the same biological drug SAN GALLICANO Berardesca Enzo Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS QUANTEC:QUantitative Analysis of Normal Tissue Effects in the Clinic.A Multicenter Italian prospective contribute to international research on radiation therapy damage,through a correlation between clinic,imaging,dosimetry and biology. Lombardia Magrini Stefano Maria CLI Oncology 2 Radiation Therapeutics and Biology RTB Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction BURLO GAROFALO Savoia Anna CLI Vascular and Hematology Hematopoiesis HP High risk preterm infants: an early diagnostic therapeutic intervention Piemonte Pomella Roberta CLI Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD Pagina 30 di 167

31 STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST UTILITY ANALYSIS Burastero Samuele CLI Healthcare Delivery and Health Services Organization and Delivery HSOD IDENTIFICATION OF MARKERS AND DEVELOPMENT OF SENSORS FOR EARLY PANCREATIC CANCER DIAGNOSIS Piemonte Novelli Francesco Bioengineering Sciences and Technologies Nanotechnology NANO Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA De Maria Ruggero Oncology 2 Cancer Immunopathology and Immunotherapy CII Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a GASLINI Eva Alessandra Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Overcoming chemoresistance in adrenocortical cancer Emilia Romagna Zatelli Maria Chiara Oncology 2 Cancer Biomarkers CBSS Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Schieppati Marco Integrative, Functional, and Cognitive Sensorimotor Integration SMI Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Columbaro Marta Cell Biology Nuclear and Cytoplasmic Structure/Function and Dynamics NCSD Explaining coronary heart disease mortality trend in Italy between 2000 and 2010 and forecasting health and economic scenarios for prevention strategies Istituto Superiore di Sanita' Palmieri Luigi Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Early detection of lung cancer in asymptomatic high risk population by low dose CT scan and molecular markers. I.E.O. Veronesi Giulia CLI Oncology 2 Cancer Biomarkers CBSS Pagina 31 di 167

32 Corrected ipsc as therapeutic source for Spinal Muscular Atrophy MAGGIORE Comi Giacomo Pietro Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) Rocco Mattia Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function D MSFD STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER AUXOLOGICO Persani Luca Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER ROLE OF INFLAMMATION/IMMUNITY IN ATHEROSCLEROSIS: ANALYSIS OF POTENTIAL NOVEL MORPHOLOGIC AND/OR CHEMICAL MARKERS OF PLAQUE PROGRESSION/STABILIZATION SAN RAFFAELE PISANA Ferroni Patrizia Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Identification of molecular markers to determine new therapeutic strategies for Phase II Trials (GCP criteria) in patients with Glioblastomas NEUROMED Marinelli Alfredo Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] INNOVATIVE TREATMENTS FOR NEUROGENETIC DISEASES AND THEIR COMPLICATIONS: ATAXIA TELANGIECTASIA Lazio CHESSA Luciana CLI Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury: a latepreclinical study NEUROLESI Genazzani Armando Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Pagina 32 di 167

33 Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna Arpesella Giorgio Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYCLIC DI GMP METABOLISM Lazio CUTRUZZOLA FRANCESCA Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Genetic predisposition to severe and recurrent infections: unravelling the pathogenic mechanisms of susceptibility SAN MATTEO Minoli Lorenzo CLI Immunology Immunity and Host Defense IHD Peri operative stress in cardiac surgery: psycho social aspects, genetic predisposition and biohumoral characterization Toscana Rovai Daniele CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Sica Antonio Oncology 1 Basic Tumor Microenvironment TME Cluster randomized trial to assess the effectiveness of a population based educational campaign on stroke symptom recognition in reducing pre hospital delay. Emilia Romagna Denti Licia CLI Healthcare Delivery and Community Level Health Promotion CLHP Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Sorarù Gianni Brain Disorders and and CNN A study to identify and validate predictive biomarkers for clinical outcome after oxaliplatin based adjuvant chemotherapy (CT) in early stage colorectal cancer (ecrc) and bevacizumab based CT in metastatic colorectal cancer (mcrc) HUMANITAS Rimassa Lorenza Oncology 2 Cancer Biomarkers CBSS Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. MAUGERI priori silvia giuliana Cardiovascular and Electrical Signaling, Ion Transport, and Arrhythmias ESTA Pagina 33 di 167

34 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility: prevention and treatment in Italian and Sudanese/Ethiopian populations. MEDEA Bresolin Nereo Brain Disorders and Developmental Brain Disorders DBD ENDOGENOUS OUABAIN IS IMPLICATED IN ACUTE KIDNEY INJURY IN CARDIAC SURGERY AND CRITICALLY ILL PATIENTS: A METABOLOMIC STUDY Manunta Paolo CLI Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread C.R.O. AVIANO Spessotto Paola Oncology 1 Basic Tumor Microenvironment TME Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Istituto Superiore di Sanita' Fontana Luigi CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Identification of organs that are reservoir of immunosoppressive cells during tumor development and progression Bellone Matteo Immunology Transplantation, Tolerance and Tumor Immunology TTT MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR CLINICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME HUMANITAS Bello Lorenzo CLI Integrative, Functional, and Cognitive Sensorimotor Integration SMI Health (cancer and atherosclerotic) risks from radiological medical imaging in grown up congenital heart disease patients Toscana Chiappa Enrico CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS PAIN AND ANALGESIA IN THE PRETERM NEWBORN: A LONGITUDINAL STUDY ON NON PHARMACOLOGIC METHODS EFFICACY AND THEIR INFLUENCE ON PAIN PROCESSING CORTICAL MATURATION BURLO GAROFALO Demarini Sergio CLI Brain Disorders and Developmental Brain Disorders DBD Pagina 34 di 167

35 OBESITY AND MALE HYPOGONADISM: WHO COMES FIRST? SAN DONATO AVERSA ANTONIO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Characterization of a mouse model of creatine transporter deficiency:development of new therapeutic strategies for an untreatable inherited disorder of metabolism STELLA MARIS Alessandrì Maria Grazia Brain Disorders and Developmental Brain Disorders DBD ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES CROB Piccoli Claudia Vascular and Hematology Hematopoiesis HP The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson s Disease OASI MARIA S.S. Ferri Raffaele Brain Disorders and and CNN Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Piemonte Chio Adriano CLI Brain Disorders and and CNN Pathogenesis of bone alterations in chronic liver diseases: study and identification of cellular and molecular mechanisms. AUXOLOGICO BIANCHI Maria Luisa Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. BIFFO STEFANO Oncology 1 Basic Cancer Molecular Pathobiology CAMP Pagina 35 di 167

36 Fatigue relief in Multiple Sclerosis by transcranial Direct Current neurostimulation (tdcs). [FaMuSne] SAN RAFFAELE PISANA tecchio franca Brain Disorders and Acute Neural Injury and Epilepsy ANIE IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Emilia Romagna Biagini Giuseppe Brain Disorders and Acute Neural Injury and Epilepsy ANIE The effectiveness of Individual Placement and Support (IPS) in clients with first episode of psychosis. Emilia Romagna FIORITTI ANGELO CLI Healthcare Delivery and Community Level Health Promotion CLHP Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy and give new insight into monogenic type 2 diabetes. OSPEDALE BAMBINO GESU' Massa ornella Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD Reorganization of cortical function after surgery for lesional epilepsy in children Toscana Barba Carmen CLI Brain Disorders and Developmental Brain Disorders DBD Biomarkers of clinical outcomes in stroke patients. Role of Alfa Melanocortin and Brain Derived Neurotrophic Factor polimorfisms in neurorehabilitation. S.CAMILLO Di Leo Rita Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Structural and functional large scale brain networks across multiple sclerosis clinical phenotypes: a graph theory approach to identify neuronal system vulnerability as a target of future therapeutic interventions Rocca Maria Assunta CLI Brain Disorders and and CNN Characterization and validation of new prognostic markers in high grade ovarian cancer. C.R.O. AVIANO SCHIAPPACAS MONICA BEAT Oncology 1 Basic Tumor Cell Biology TCB Research of biomarkers in peripheral blood and tissue specimens for early diagnosis and prediction of therapy response in patients with colorectal cancer. Emilia Romagna Lippi Giuseppe Oncology 2 Cancer Biomarkers CBSS EBV reactivation and CD8+ T cell responses in Multiple Sclerosis SANTA LUCIA Battistini Luca CLI Immunology Hypersensitivity, Autoimmune, and Immune Pagina 36 di 167

37 Use of Tranexamic acid in elective orthopaedic prosthetic surgery for preventing blood loss. Veneto Toffoletto Fabio CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT In Vivo Detection of Cholangiocarcinoma at ERCP: Confocal Laser Endomicroscopy and Intraductal Aspiration. Sicilia traina mario CLI Oncology 2 Oncology CONC Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia SAN MATTEO Balduini Carlo CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD ENVIROMENTAL ENRICHMENT AS A TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS WITH INTELLECTUAL DISABILITY STELLA MARIS Bargagna Stefania CLI Brain Disorders and Developmental Brain Disorders DBD Impact of tobacco control policies and implementation of tobacco control interventions Toscana GORINI GIUSEPPE Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCERCHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' Masella Roberta Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP Effect of chemotherapy on ovarian reserve oocytes and role of p63 Lazio Piccione Emilio Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction CMIR Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO Pastorino Ugo CLI Oncology 2 Cancer Biomarkers CBSS INTERMEDIATE INTENSIVE CARE UNIT (IICU CRITICAL AREA ) Emilia Romagna Brugioni Lucio CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 37 di 167

38 MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Maroni Paola Maria Oncology 1 Basic Tumor Progression and Metastasis TPM A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. PASCALE Scala Stefania Oncology 2 Developmental Therapeutics DT Exploring Ng MIP Neisseria gonorrhoeae Macrophage Infectivity Potentiator) and Ng OMPA (Neisseria gonorrhoeae Outer Membrane Protein A) as novel candidates to fight gonococcal infection due to resistant or multi drug resistant gonococci Istituto Superiore di Sanita' Stefanelli Paola Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship F Effects of sleep disturbances on the occurrence of postextubation respiratory failure and related mortality Emilia Romagna nava stefano CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO Anichini Andrea Oncology 1 Basic Tumor Cell Biology TCB Prevalence of risk factors for cardiovascular and non viral hepatic diseases: an epidemiological study in two Italian populations Istituto Superiore di Sanita' MELE ALFONSO Population Sciences and Epidemiology Cardiovascular and Sleep Epidemiology CASE Target definition of tumors in positron emission tomography: development and validation of a software tool to be installed on radiotherapy treatment planning systems Piemonte Krengli Marco Oncology 2 Radiation Therapeutics and Biology RTB Obesity as an intermediate phenotype of cardiovascular disease and cancer: in vivo and in vitro studies on tissue factor expression and related processes HPV INFECTION IN A COHORT OF HIV POSITIVE MEN AND WOMEN: VIRO IMMUNOLOGICAL CORRELATES OF HPV DISEASE PROGRESSION AT GENITAL AND ORAL SITES Molise Lorenzet Roberto Vascular and Hematology Hemostasis and Thrombosis HT Lombardia d'arminio Mon antonella CLI AIDS and Related Research AIDS Associated Opportunistic Infections and Cancer AOIC Pagina 38 di 167

39 Andrological Screening and Reproductive Health in Young Adult Males Veneto Foresta Carlo CLI Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions IRAP Monitoring of heavy metals and nanoparticles in fishes and babyfoods of animal origin Istituto Zooprofilattico Sperimentale della Sicilia Ferrantelli Vincenzo Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA Role of extracellular Tat in HIV infection Istituto Superiore di Sanita' Nappi Filomena AIDS and Related Research AIDS Molecular and Cellular Biology AMCB C Choline PET/CT as Image Guide for radiotherapic treatment of prostate cancer recurrent lymphnodes Picchio Maria CLI Oncology 2 Cancer Biomarkers CBSS mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Istituto Superiore di Sanita' Care' Alessandra Oncology 1 Basic Molecular Oncogenesis MONC Comparative analysis of the leukemia associated fusion proteins TEL/AML1 and AML1/ETO. I.E.O. Alcalay Myriam Vascular and Hematology Hematopoiesis HP Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana Santini Ferruccio Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Cognitive rehabilitation after stroke: a randomized controlled trial to compare the efficacy of different protocols. Sicilia MANDALA' GIORGIO CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna GALLERANI MASSIMO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 39 di 167

40 CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF EPITHELIAL SKIN CANCERS MAUGERI Faga Angela CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Small Business Novel Technologies for In Vivo Imaging and Image SBNT Biological nurturing and exclusive breastfeeding at 12 weeks: a randomised controlled trial BURLO GAROFALO Cattaneo Adriano CLI Healthcare Delivery and Nursing Science: Children and Families NSCF Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. SAN RAFFAELE PISANA Sabatelli Mario Brain Disorders and and CNN A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Emilia Romagna Caraceni Paolo CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG An integrated genomic and immunologic approach to novel strategies of monitoring and therapy for HBV and HCV infections Emilia Romagna Ferrari Carlo Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Cerebellar transcranial magnetic stimulation as a treatment option for levodopa induced dyskinesias and tremor NEUROMED Berardelli Alfredo CLI Brain Disorders and and CNN Genetic polymorphisms in genes of drug related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma. I. O. V. Saggioro Daniela CLI Oncology 2 Cancer Biomarkers CBSS PCA3,ADVANCED MAGNETIC RESONANCE IMAGING TECHNIQUES AND TISSUE AND CIRCULATING MOLECULAR MARKERS IN PROSTATE CANCER: DEFINING A NOVEL DIAGNOSTIC AND PROGNOSTIC ALGORITHM PASCALE Perdonà Sisto CLI Oncology 2 Cancer Biomarkers CBSS Pagina 40 di 167

41 IN VITRO GENERATION OF HEMOGENIC ENDOTHELIUM FROM HUMAN CORD BLOOD: A NEW TOOL FOR STUDYING THE DEVELOPMENT OF THE HEMATOPOIETIC SYSTEM AND FOR REGENERATIVE MEDICINE Istituto Superiore di Sanita' Pelosi Elvira Cell Biology Cellular Signaling and Regulatory Systems CSRS Enhanced cell proliferation for muscle repair and regenerative medicine Istituto Superiore di Sanita' Crescenzi Marco Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE De Luca Antonella Oncology 1 Basic Tumor Microenvironment TME Screening of the genetic alterations in patients affected by high myopia Veneto galan alessandro Genes, Genomes and Genetics Genetics of Health and Disease GHD Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes Lazio Pugliese Giuseppe CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, Cost Effective Algorithm Sicilia Barresi Luca CLI Oncology 2 Oncology CONC Role of the ghrelin gene derived peptides and growth hormone releasing hormone (GHRH) on microrna expression and function in the heart Piemonte Granata Riccarda Cardiovascular and Myocardial Ischemia and Metabolism MIM Cytokines as biomarkers of disease and therapeutic targets in laminopathies RIZZOLI MARALDI NADIR MARIO Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Cardiotoxicity from antracyclines and trastuzumab in the adjuvant treatment of breast cancer: early identification of high risk patients with a panel of biomarkers compared to traditional ecocardiographic evaluation. I. O. V. Banzato Alberto CLI Oncology 2 Oncology CONC Pagina 41 di 167

42 TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING HUMANITAS Mantovani Alberto Oncology 1 Basic Tumor Microenvironment TME Molecular subtype based follow up program in patients treated for early breast cancer Emilia Romagna Frassoldati Antonio CLI Oncology 2 Cancer Biomarkers CBSS Cardiac output regulation in artificial hearts MONZINO Agostoni Piergiuseppe CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Immunesurveillance of leukemia by CD1 restricted T cells specific for self lipid antigens Casorati Giulia Immunology Transplantation, Tolerance and Tumor Immunology TTT Campylobacter, L. monocytogenes and Verocytotoxinproducing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Calistri Paolo Veterinary Food Safety FOSA Establishing the early profile of chronic renal allograft dysfunction with functional magnetic resonance and contrast enhanced ultrasound DE COBELLI FRANCESCO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Identification of signaling pathway activation profiles in cancer stem cells by mass cytometry, comparison with the reverse phase protein array approach and correlation with sensitivity to pathway targeting drugs. Istituto Superiore di Sanita' Biffoni Mauro Oncology 1 Basic Tumor Cell Biology TCB Common pathogenic pathways in Motor Neuron Diseases : a study on the relation between SMN and TLS/FUS SANTA LUCIA CARRI MARIA TERESA Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA De Luca Alessandro Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 42 di 167

43 Development of a novel lubricating gel containing antimicrobial loaded nanoparticles to prevent urinary catheter associated infections particularly in patients with neurogenic bladder requiring long term catheterization. SANTA LUCIA Donelli Gianfranco CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS New treatments for alleviation of neuropathy and regenerative impairment in diabetes. MULTIMEDICA Madeddu Paolo Cardiovascular and and Integrative Cardiovascular Sciences CICS Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Emilia Romagna Muratori Luigi Immunology Hypersensitivity, Autoimmune, and Immune UNMET NEEDS, QUALITY OF LIFE AND FAMILY BURDEN AMONG ICHTHYOSIS PATIENTS ISTITUTO DERMOPATICO DELL'IMMACOLATA Tabolli Stefano CLI Healthcare Delivery and Health Services Organization and Delivery HSOD ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna Caffarra Paolo CLI Brain Disorders and and CNN Identification of biomarkers for an early diagnosis of periprosthetic osteolysis Piemonte Ferracini Riccardo Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS The role of mirna in MYC regulatory network Toscana Leoncini Lorenzo Oncology 1 Basic Cancer Molecular Pathobiology CAMP MESOANGIOBLASTS FOR THE CELL THERAPY OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING SKELETAL MUSCLE DIFFERENTIATION OF FSHD MESOANGIOBLASTS IN VITRO AND IN VIVO IN SCID MICE AND IN A MOUSE MODEL OF FSHD. DON GNOCCHI MOROSETTI ROBERTA Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE Pagina 43 di 167

44 Mast cells translate external challenges into immune regulation affecting colitis and colorectal cancer. ISTITUTO TUMORI MILANO Colombo Mario Paolo Immunology Transplantation, Tolerance and Tumor Immunology TTT Efficacy and safety of early and intensive rehabilitative interventions in patients with stroke. A randomized controlled trial SANTA LUCIA Musicco Massimo CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Role of glucocorticoid induced leucine zipper (GILZ) in autoimmunity Istituto Superiore di Sanita' Pierdominici Marina Immunology Hypersensitivity, Autoimmune, and Immune Viral respiratory infections in intensive care patients. Toscana Peris Adriano Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial FATEBENEFRATELLI de Girolamo Giovanni CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA THE EFFECTIVENESS OF STRUCTURED PSYCHOEDUCATION FOR RELAPSE PREVENTION IN BIPOLAR DISORDERS FATEBENEFRATELLI CLERICI MASSIMO CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Istituto Superiore di Sanita' La Rosa Giuseppina Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Fertility preservation in young Oncological female patients REGINA ELENA Vizza Enrico CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction CMIR Environmental and biological monitoring of exposure to traffic related air pollution for outdoor workers and evaluation of genotoxic and cardiovascular effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Tranfo Giovanna Population Sciences and Epidemiology Epidemiology of Cancer EPIC Pagina 44 di 167

45 HIV drug resistance in resource limited settings : an assessment in naïve pregnant women in Malawi and the evaluation of the impact of a triple antiretroviral combination strategy for PMTCT Istituto Superiore di Sanita' Giuliano Marina AIDS and Related Research AIDS Studies and Epidemiology ACE EPIGENETIC DETERMINANTS OF DRUG SENSITIVITY AND CLINICAL OUTCOME IN OVARIAN CANCER HUMANITAS Gasco Milena Oncology 2 Oncology CONC Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches SAN MATTEO Merlini Giampaolo Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function E MSFE Chronic kidney disease and cardiovascular risk in Italy. A population based longitudinal study exploiting the CNESPS ISS biological specimen bank Istituto Superiore di Sanita' Giampaoli Simona Population Sciences and Epidemiology Kidney, Nutrition, Obesity and Diabetes KNOD EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: CLINICAL/REHABILITATIVE IMPLICATIONS FOR DISORDERS OF SPATIAL ATTENTION IN STROKE PATIENTS SANTA LUCIA OLIVERI MASSIMILIANO CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Combined therapeutic cancer vaccine strategy for HCVrelated HCC PASCALE Luigi Buonaguro Oncology 2 Cancer Immunopathology and Immunotherapy CII Targeting CD99 to treat sarcomas RIZZOLI Scotlandi Katia Oncology 2 Developmental Therapeutics DT Optimization of the clinical management of endocrineresponsive early breast cancer patients IRCCS AOU San Martino IST (Genova) Del Mastro Lucia CLI Oncology 2 Oncology CONC Danger associated molecular patterns: revealing the molecular signals dictating the communication between dying cells with the immune system Istituto Superiore di Sanita' Meschini Stefania Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 45 di 167

46 A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATIONS IN ATM, OCT and MATE GENES IN THE GLYCAEMIC RESPONSE TO METFORMIN IN DRUG NAÏVE TYPE 2 DIABETIC PATIENTS AUXOLOGICO Invitti Cecilia Genes, Genomes and Genetics Genetics of Health and Disease GHD Deciphering the Transcriptional Signature of Sporadic Brain Arteriovenous Malformations: a Genome Wide Expression Study Istituto Superiore di Sanita' Maira Giulio Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Simultaneous inhibition of PARP and homologous recombination: a new hypothesis for radiosensitization ONCOLOGICO DI BARI Azzariti Amalia Oncology 2 Radiation Therapeutics and Biology RTB Pathogenesis of idiopathic thromboembolism: role of antiendothelial auto antibodies and endothelial cell dysfunctions. HUMANITAS Della Bella Silvia Immunology Hypersensitivity, Autoimmune, and Immune EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Prearo Marino Veterinary Food Safety FOSA Non invasive assessment of liver steatosis and fibrosis, and lymph nodes diseases in pediatric patients. SAN MATTEO Filice Carlo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana Masini Emanuela Brain Disorders and Brain Injury and Neurovascular Pathologies BINP A MODEL TO EVALUATE EFFECTIVENESS AND APPROPRIATENESS OF DRUGS USING THE ITALIAN RFOM REGISTRY I. O. V. JIRILLO ANTONIO CLI Healthcare Delivery and Healthcare Delivery and Small Business SBHD Pagina 46 di 167

47 PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) AMONG ITALIAN REGIONS Lazio Ceccanti Mauro CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM WNT signaling in the pathogenesis and treatment of Bipolar Disorder BENEDETTI FRANCESCO Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Gurtner Aymone Oncology 1 Basic Cancer Molecular Pathobiology CAMP Evaluation of CARDIac function in patients with chronic LIVER disease (CARDIO LIVER) Toscana Bartolozzi Carlo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Telomere Length, Risk of Ischemic Stroke and Prediction of Poststroke Recurrent Events NEUROLESI padovani alessandro CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Parkinson's Disease: a new approach to motor and cognitive neurorehabilitation FATEBENEFRATELLI Cotelli Maria Brain Disorders and and CNN Long term immune monitoring of patients with psoriasis or psoriatic arthritis treated with drugs targeting key mediators of the immune response to identify key parameters of therapeutic efficacy and/or disease progression PEPTIDE FROM PARIETARIA JUDAICA POLLEN WITH ANTI MICROBIAL ACTIVITY AS A NEW THERAPEUTICAL TOOL: EVALUATION OF INTERACTION WITH THE IMMUNE SYSTEM SAN GALLICANO Cordiali Fei Paola Immunology Hypersensitivity, Autoimmune, and Immune Istituto Superiore di Sanita' CORINTI SILVIA Immunology Immunity and Host Defense IHD Pagina 47 di 167

48 Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA Bozzali Marco CLI Brain Disorders and and CNN Smoking behavior in patients with established ischemic vascular disease from the Moli sani cohort study Molise Zito Francesco Population Sciences and Epidemiology Cardiovascular and Sleep Epidemiology CASE Muscle fibrosis in DMD: Molecular characterization with a new human in vitro model and therapeutic approach CARLO BESTA Zanotti Simona Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE High throughput parallel sequencing of Mycobacterium avium subsp. paratuberculosis in sheep, of affected/non affected sheep transcriptome and of environmental samples. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana de grossi luigi Veterinary Animal Health ANHE Systemic Treatment plus Radiofrequency Ablation versus systemic treatment alone in patients with non resectable colorectal liver metastases. Emilia Romagna CAVANNA LUIGI CLI Oncology 2 Oncology CONC Experimental models for investigation of interrelationship between CSCs/TICs and metastasis Emilia Romagna Ibrahim Toni Oncology 1 Basic Tumor Progression and Metastasis TPM A comprehensive immunological strategy for the prevention of relapse in elderly patients with acute myeloid leukemia according to genotype: adoptive immunotherapy with NK cells and anti WT1 vaccination Emilia Romagna Curti Antonio CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Proteomic signatures as biomarkers of breast cancer risk andas predictors of outcome in women with early breast cancer. IRCCS AOU San Martino IST (Genova) Boccardo Francesco Oncology 2 Cancer Biomarkers CBSS Effects of the prebiotic inulin in the treatment of chemotherapy induced mucositis and related alterations in gut microbiota DE BELLIS Russo Francesco Oncology 2 Chemo/Dietary Prevention CDP Pagina 48 di 167

49 DEFINING INNOVATIVE TREATMENT STRATEGIES FOR OSTEOSARCOMA BASED ON THE INHIBITION OF ABC TRANSPORTERS AND PROTEIN KINASES RIZZOLI Serra Massimo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Novel strategies in the pathogenesis, epidemiology and prognostic factors of papillary thyroid cancer Toscana Molinaro Eleonora Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology MCE Predictive factors of response to therapies in colorectal and breast cancers. MAUGERI Stassi Giorgio Oncology 1 Basic Cancer Molecular Pathobiology CAMP Development of novel cell products for their clinical use in cancer immunotherapy Istituto Superiore di Sanita' Belardelli Filippo Oncology 2 Cancer Immunopathology and Immunotherapy CII Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (15 24 years), in Italy Istituto Superiore di Sanita' Suligoi Barbara CLI Population Sciences and Epidemiology Behavioral Genetics and Epidemiology BGES Thrombolysis in Minor Stroke Emilia Romagna guidetti donata CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Optimising Natural Killer (NK) cell activation for liver anti fibrogenic immunotherapy. SAN MATTEO Varchetta Stefania Immunology Innate Immunity And Inflammation III An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Galarini Roberta Veterinary Food Safety FOSA Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) Bianchi Scarrà Giovanna Oncology 1 Basic Cancer Genetics CG Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating Patients Satisfaction and Multidisciplinary Team Working ISTITUTO TUMORI MILANO Valdagni Riccardo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 49 di 167

50 Gene expression profile and epigenetic regulation in human white adipose tissue AUXOLOGICO Cancello Raffaella Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Epstein Barr virus infection and risk of developing autoimmune disease Istituto Superiore di Sanita' Aloisi Francesca Immunology Hypersensitivity, Autoimmune, and Immune Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia SANTA LUCIA Pisani Antonio Brain Disorders and and CNN Development and preclinical testing of novel adenosine 2A receptor antagonists for the treatment of Parkinson s disease and clinical implementation of potential adenosine receptor related biomarkers MONDINO Armentero Marie Therese Brain Disorders and and CNN Beta adrenergic receptor blockade as a new, effective and safe therapy in the treatment of retinopathy of prematurity Toscana Filippi Luca Cell Biology Retinopathy Special Emphasis Panel (SEPR) ANORECTAL MALFORMATIONS (ARM): A MULTIDISCIPLINARY RESEARCH TO IDENTIFY PREDISPOSING FACTORS AND NEW THERAPEUTICAL APPROACHES Veneto Gamba Piergiorgio Genes, Genomes and Genetics Genetics of Health and Disease GHD A translational study to identify and validate predictive molecular and cytogenetic biomarkers of durable complete response to trastuzumab containing chemotherapy for HER2 positive metastatic or locally advanced breast cancer HUMANITAS Torrisi Rosalba Oncology 2 Cancer Biomarkers CBSS Perioperative markers of neurological and lung damage in infants with congenital heart diseases (CHD). A three years follow up study. OSPEDALE BAMBINO GESU' Cogo Paola CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 50 di 167

51 Identification of mechanisms of resistance to EGFR tyrosine kinase inhibitors in non small cell lung carcinoma (NSCLC) and monitoring the molecular evolution of lung tumors PASCALE Normanno Nicola CLI Oncology 2 Cancer Biomarkers CBSS Effective functional measurements in musculoskeletal rehabilitation: guidelines, methodologies and tools for accreditation, assessment and appropriate performance of Movement Analysis Laboratories Istituto Superiore di Sanita' Giacomozzi Claudia Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Integration of an inpatient clinical research in medical oncology within an intensity of care focused hospital (ICFH) model Liguria Lionetto Rita CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Istituto Superiore di Sanita' Fiorentini Carla Brain Disorders and Developmental Brain Disorders DBD Thyroid hormone treatment as a novel therapeutic strategy to prevent post ischemic cardiac remodeling Toscana Iervasi Giorgio Cardiovascular and and Integrative Cardiovascular Sciences CICS Abscisic acid, a new endogenous modulator of insulin release and glucose uptake: pre clinical studies of its use to improve the clinical assessment and design novel therapies for diabetes mellitus. IRCCS AOU San Martino IST (Genova) Murialdo Giovanni Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Development of an in vitro assay for the diagnosis of latent tuberculosis infection (LTBI) based on a novel human immunodominant T cell epitope of the antigen PPE44 of Mycobacterium tuberculosis Toscana Garzelli Carlo Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP Telecare and Home Care: assessing cost effectiveness of a new approach to increase safety in home care avoiding the need to hospitalize for elderly, polypathologic, chronically ill, unstable subjects with movement handicaps Toscana Ghiselli Pier Carlo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 51 di 167

52 AEQUITAS: Inequality and Quality of regional clinical pathways in diabetes management Marche paolini italo CLI Population Sciences and Epidemiology Kidney, Nutrition, Obesity and Diabetes KNOD Localizing the epileptogenic zone in presurgical evaluation of drug resistant focal epilepsies: a complex network based approach CARLO BESTA Panzica Ferruccio Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ZRCM NEW MOLECULAR APPROACHES FOR THE DETECTION OF DIOXINS AND DIOXIN LIKE COMPOUNDS IN EXPOSED SHEEP Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta NEBBIA CARLO Veterinary Food Safety FOSA Towards the understanding of the molecular bases of HIV latency Montini Eugenio AIDS and Related Research AIDS Immunology and Pathogenesis AIP NCRpos Vd1 T cells: role of a newly disclosed gammadelta T cell subset in eradicatingtumors, in suppressing HIV 1 replication and in modulating the homeostasis of gut mucosalimmunity. HUMANITAS Mavilio Domenico Immunology Cellular and Molecular Immunology B CMIB Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Claudio Sette Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Ensuring the safety of human stem cells: evaluation of genomic stability and metrological assessment of regenerative medicine products Piemonte De Marchi Mario Genes, Genomes and Genetics Molecular Genetics MGA Pagina 52 di 167

53 Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost benefit analysis. Toscana Pacini Furio CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Cell stress mediators in cancer stroma interaction as targets for drug development SDN Laukkanen Mikko Oncology 1 Basic Tumor Microenvironment TME research in breast cancer metastases to the brain: a multidisciplinary approach to identify molecular pathways for the development of new therapeutic strategies I.E.O. Munzone Elisabetta CLI Oncology 2 Cancer Biomarkers CBSS SMALL PEPTIDES AS A NEW STRATEGY FOR THE THERAPY OF CELIAC DISEASE Istituto Superiore di Sanita' Silano Marco Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology GMPB Purinergic modulation of SDF 1/CXCR4 directed endothelial and cardiac progenitors cell functions: theraupetic potential in cardiovascular regeneration. SAN RAFFAELE PISANA Melchionna Roberta Cardiovascular and Myocardial Ischemia and Metabolism MIM THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING CLINICAL DISORDERS Camaschella Clara Vascular and Hematology Erythrocyte and Leukocyte Biology ELB GENETIC DETERMINANTS OF LEFT VENTRICULAR HYPERTROPHY AUXOLOGICO Giannattasio Cristina Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man Battaglia Marco Maria Population Sciences and Epidemiology Behavioral Genetics and Epidemiology BGES Pagina 53 di 167

54 Efficacy of a neuromotor and cognitive behavioural training for disability, kinesiophobia and gait disturbances in chronic non specific low back pain MAUGERI Monticone Marco CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Extreme Obesity and Sleep Apnoea Syndrome: Redox Balance, Inflammation and Vitamin Profile. Effect of metabolic rehabilitation and non invasive mechanical ventilation. AUXOLOGICO LIUZZI ANTONIO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Evaluation of AIFA monitored antineoplastic drugs in advanced cancer patients in the last months of life in Regione Emilia Romagna Emilia Romagna Leoni Maurizio CLI Healthcare Delivery and Health Services Organization and Delivery HSOD MODULATING NEUREGULIN 1 SIGNALS TO TREAT HEREDITARY DEMYELINATING NEUROPATHIES Taveggia Carla Molecular, Cellular, and Developmental Cellular and Molecular Biology of Glia CMBG Rehabilitation in Chronic Disability: Connecting Care 2.0 Lombardia Limonta Fabrizio CLI Healthcare Delivery and Biomedical Computing and Health Informatics BCHI TRAIN: Training through Research Application Italian initiative Istituto Superiore di Sanita' Lombardo Claudio Giusepp Interdisciplinary Molecular Sciences and Training Fellowship: Oncological Sciences F Allergy management based on the neonatal risk: a technological pathway. SAN MATTEO De Amici Mara Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO TRANSMISSION OF SPORADIC CREUTZFELDT JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES Istituto Superiore di Sanita' Ladogana Anna Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions IRAP Identification of new gender associated biomarkers in metabolic syndrome Istituto Superiore di Sanita' straface elisabetta CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 54 di 167

55 Development of novel drugs targeting protozoan agents of tropical diseases imported in Italy Istituto Superiore di Sanita' Severini Carlo Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer, cardiovascular diseases and neurodegenerative disorders in healthy subjects. SAN RAFFAELE PISANA Bonassi Stefano Population Sciences and Epidemiology Epidemiology of Cancer EPIC Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis RIZZOLI Zaffagnini Stefano CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO Perego Paola Maria Chi Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets Istituto Superiore di Sanita' LABBAYE Catherine Simon Oncology 1 Basic Molecular Oncogenesis MONC Development of an exosome based in vivo test to detect prions in blood Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta CASALONE CRISTINA Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies Sicilia Maggio Aurelio Vascular and Hematology Hematology Small Business Activities SBIR/STTR SBHE Characterization of the genomic architecture of myelodysplastic syndromes and definition of a molecular basis for their classification and prognostication SAN MATTEO Cazzola Mario Oncology 1 Basic Cancer Genetics CG Pagina 55 di 167

56 The role Inflammation and wound healing mechanisms in lung cancer biological behaviour and outcome prediction after surgical resection HUMANITAS INFANTE Maurizio V Oncology 1 Basic Tumor Microenvironment TME Italian study on gene environment interactions in lymphoma aetiology: translational aspects Toscana Miligi Lucia Oncology 1 Basic Cancer Etiology CE Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Pini Alessandro Infectious Diseases and Microbiology Small Business: Non HIV Anti Infective Therapeutics SBN CORONARY ATHEROSCLEROSIS IN THE YOUNG: EARLY DIAGNOSIS AND IDENTIFICATION OF RISK FACTORS FOR SUDDEN DEATH PREVENTION Veneto Thiene Gaetano CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment SANTA LUCIA Orlando Valerio Genes, Genomes and Genetics Molecular Genetics MGA Biomarkers and prognostic factors in psoriasis and psoriatic arthritis: a prospective cohort study Lombardia NALDI LUIGI CLI Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Disentangling prenatal and postnatal influences on infant bio behavioral development: a prospective study. MEDEA Frigerio Alessandra Biobehavioral and Behavioral Processes Psychopathology, Developmental Disabilities, Stress and Aging Fellowship F12B High resolution array CGH study in patients with infancy epileptic encephalopathies of unknown etiology. OASI MARIA S.S. Elia Maurizio Brain Disorders and Developmental Brain Disorders DBD Treatment of Neurological Impairment in Lysosomal StorageDiseases by the Use of Neural Stem Cells CASA SOLLIEVO SOFFERENZA De Filippis Lidia Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana Giunta Francesco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 56 di 167

57 Improving accuracy in cardiovascular disease risk prediction by metabolic markers in the Italian population Lombardia BRAMBILLA PAOLO Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A CLINICAL, MORPHOLOGIAL CEREBRAL AND LOGICAL COMPARISON STUDY FATEBENEFRATELLI PAOLO SANTONASTAS Brain Disorders and and CNN Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Colombo Emanuela Oncology 1 Basic Tumor Cell Biology TCB The role of diet in psoriasis ISTITUTO DERMOPATICO DELL'IMMACOLATA Abeni Damiano CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedule in patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna Brandi Giovanni CLI Oncology 2 Oncology CONC EARLY START EXERCISE TRAINING AFTER ACUTE DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE: FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, NEUROHUMORAL ACTIVATION AND QUALITY OF LIFE. MAUGERI GIANNUZZI PANTALEO CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA SDN ANNUNZIATO LUCIO Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Istituto Superiore di Sanita' Torosantucci Antonella Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Pagina 57 di 167

58 Role of TIR8, a novel member of IL 1R/TLR family with a negative regulatory activity, in inflammation and cancer. HUMANITAS Garlanda Cecilia Immunology Innate Immunity And Inflammation III Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease MAUGERI Nardone Antonio CLI Brain Disorders and and CNN Mathematical modelling of mosquito borne diseases in Italy Istituto Superiore di Sanita' Vescio Fenicia Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions IRAP Surgical aortic valve replacement versus transcatheter aortic valve implantation in patients 80 years and older at low surgical risk:the ELDERLY VALVE Trial Colombo Antonio CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS Landsberger Nicoletta Molecular, Cellular, and Developmental Synapses, Cytoskeleton and Trafficking SYN Analysis of immunogenicity of putative GPI anchored proteins of Babesia for vaccine and diagnostic purposes Istituto Zooprofilattico Sperimentale della Sicilia Torina Alessandra Veterinary Animal Health ANHE Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese Istituto Zooprofilattico Sperimentale del Mezzogiorno Corrado Federica Veterinary Food Safety FOSA Functional and viability impairment of cardiomyocytes in familial amyloid polyneuropathy Toscana Mugelli Alessandro Cardiovascular and Electrical Signaling, Ion Transport, and Arrhythmias ESTA Heterotypic interactions in thrombo inflammatory processes associated with the thrombotic vascular occlusion in sepsis: the role of vitamin K dependent protein C Maugeri Norma Vascular and Hematology Hemostasis and Thrombosis HT Pagina 58 di 167

59 A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) Piemonte COMOGLIO Paolo Maria Oncology 1 Basic Cancer Molecular Pathobiology CAMP Telemonitoring in Heart Failure Liguria Brignole Michelino CLI Bioengineering Sciences and Technologies Biodata Management and Analysis BDMA IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE Emilia Romagna Lemoli Roberto Massim CLI Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology GMPB EXPERIMENTAL EVIDENCES ON POSSIBLE TOXIC EFFECTS OF LEVODOPA ON MAMMALIAN SUBSTANTIA NIGRA DOPAMINERGIC NEURONS SANTA LUCIA Mercuri Nicola Biagio Brain Disorders and Cell Death in CDIN Reproductive toxicity of Engineered Nanomaterials: mechanisms, effects, biomonitoring and tools for prevention Lazio Pietroiusti Antonio Bioengineering Sciences and Technologies Nanotechnology NANO Influence of metabolic factors on inflammation of colorectal mucosa in colorectal cancer risk assessment Emilia Romagna Roncucci Luca Oncology 2 Cancer Biomarkers CBSS Diagnosis and Management in Sicilian patients with Rare Diseases leading to Intellectual Disability: a Community evaluation and shared plan of improvement. OASI MARIA S.S. ROMANO CORRADO CLI Healthcare Delivery and Community Influences on Health Behavior CIHB IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO Mazzaferro Vincenzo CLI Oncology 2 Cancer Biomarkers CBSS Low dose effects: in vivo models of chemotherapyradiation therapy interactions Emilia Romagna Benassi Marcello Oncology 2 Radiation Therapeutics and Biology RTB mirna driven conditional attenuation of viral vaccines Siccardi Antonio Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Pagina 59 di 167

60 Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in the Italian NHS Agenzia per i Servizi Sanitari Regionali Perucci Carlo A. CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Characterization of HIV related mechanisms involved in the development of Burkitt s lymphoma Emilia Romagna Gibellini Davide AIDS and Related Research AIDS Immunology and Pathogenesis AIP Pathway Dissection In Leukocyte Migration: Identification And Validation Of Novel Therapeutic Targets In Nonresolving Inflammation Pardi Ruggero Immunology Innate Immunity And Inflammation III Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Emilia Romagna Lauretani Fulvio CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME High throughput monitoring of pathogen specific cellular immunity as guidance for treatment of opportunistic infections in immunocompromised children. OSPEDALE BAMBINO GESU' Li Pira Giuseppina CLI Immunology Immunity and Host Defense IHD Mechanisms of beneficial effects of physical exercise on healthy aging and neurological age related diseases MAUGERI Rengo Franco Biology of Development and Aging Aging Systems and Geriatrics ASG Study of the role of immune activation and immune senescence in the pathogenesis of atherosclerosis and bone metabolism disorders in HIV infected patients undergoing highly active antiretroviral therapy (HAART) Lombardia BINI TERESA CLI AIDS and Related Research AIDS Studies and Epidemiology ACE A Multi center 3T MR Assessment of T2 Perfusion and T1 Permeability in brain Gliomas: the MAPPING study Falini Andrea CLI Oncology 2 Cancer Biomarkers CBSS Maternal metabolic hormones impact on human breast during pregnancy. Abruzzo Patacchiola Felice CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Pagina 60 di 167

61 DEVELOPMENT OF A NETWORK BASED MODEL FOR A COMPREHENSIVE CLINICAL DIAGNOSTIC MANAGEMENT OF HEREDITARY CANCER PATIENTS AND THEIR FAMILY MEMBERS I. O. V. Montagna Marco CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Antiplatelet aspirin therapy and megakaryocytic gene expression: molecular and cellular mechanisms underlying "drug resistance" in preventing cardiovascular events. Istituto Superiore di Sanita' Guerriero Raffaella Vascular and Hematology Hemostasis and Thrombosis HT Ultraviolet solar radiation and aromatic hydrocarbons as carcinogenic factors in outdoor workplaces: exposure quantification and biomarkers identification aimed at the identification of principal effects and possible synergistic effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Sisto Renata Population Sciences and Epidemiology Epidemiology of Cancer EPIC Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia Mammina Caterina CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Telemonitoring in long term ventilator dependent patients: a multicenter randomized controlled study Toscana Ambrosino Nicolino CLI Cardiovascular and Small Business Activities ZRRS Neuropsychological, neuropshysiological and neuroimaging markers of progression in prodromal Alzheimer disease (AD): an interdisciplinary approach to the early detection of AD patients SAN RAFFAELE PISANA Marra Camillo CLI Biology of Development and Aging Aging Systems and Geriatrics ASG A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' Bruno Dallapiccola CLI Healthcare Delivery and Health Services Organization and Delivery HSOD CHRONIC KIDNEY DISEASE (CKD) AND CARDIOVASCULAR RISK. MOLECULAR MECHANISMS, CLINICAL IMPLICATIONS AND NEW PREVENTIVE STRATEGIES Lombardia pozzi claudio CLI Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD Pagina 61 di 167

62 A prospective study on Oxaliplatin neurotoxicity: from basic science to rehabilitation looking for early preclinical signs of neuropathy. S.CAMILLO Briani Chiara CLI Oncology 2 Oncology CONC GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO Arbustini Eloisa CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Broccoli Vania Molecular, Cellular, and Developmental Neurogenesis and Cell Fate NCF Dominant optic atrophy (DOA) and OPA opathies in Italy: prevalence, phenotypes, genes and functional studies towards a therapy Istituto Scienze Neurologiche Carelli Valerio Brain Disorders and and CNN Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) Tonini Gian Paolo Oncology 1 Basic Molecular Oncogenesis MONC The effects of different rehabilitation treatments on left unilateral neglect S.CAMILLO Priftis Konstantinos CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO INSTITUTION OF A REGIONAL MULTIDISCIPLINARY NETWORK FOR FERTILITY PRESERVATION IN CANCER SURVIVORS. CREATION AND IMPLEMENTATION OF AN INNOVATIVE ORGANIZATIONAL MODEL ISTITUTO TUMORI MILANO Raspagliesi Francesco CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Casciaro Sergio Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology BMIT Genetic determinants of heart failure (HF) Friuli Venezia Giulia Gianfranco Sinagra Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Pagina 62 di 167

63 Role of the master transcription factor Yin Yang 1 (YY1) in the diagnosis of bone lesions SDN NAPOLI CLAUDIO CLI Oncology 2 Cancer Biomarkers CBSS Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets PASCALE Izzo Francesco CLI Oncology 2 Cancer Biomarkers CBSS And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA Aglioti Salvatore Maria Biobehavioral and Behavioral Processes Motor Function, Speech and Rehabilitation MFSR Epigenetic memory and impairment of human endothelial and mesenchymal progenitor activity by cardiovascular risk factors MONZINO Pesce Maurizio Cardiovascular and Cardiovascular Differentiation and Development CDD Improving surgical treatment of traumatic nerve injuries by artificial nerve guides: a benefit for the patient and the community Lazio Merolli Antonio CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation CARLO BESTA Sala Carlo Molecular, Cellular, and Developmental Synapses, Cytoskeleton and Trafficking SYN Surveillance of the circulation of rotaviruses in the infantile population of Sicily in view of the introduction of rotavirus vaccination. Sicilia Giammanco Giovanni Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology SAN RAFFAELE PISANA Cardinale Alessio Brain Disorders and and CNN The modulation of T helper cell death as therapeutic approach to reduce the pathogenic cells in Multiple Sclerosis (MS). SANTA LUCIA Barilà Daniela CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Pagina 63 di 167

64 Oxidative stress and fat profile in neuromuscular disorders with pediatric onset before and after a rationally modified dietary regimen. Istituto Scienze Neurologiche pini antonella CLI Brain Disorders and and CNN Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Istituto Zooprofilattico Sperimentale della Sardegna Marianelli Cinzia Veterinary Food Safety FOSA New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI MARCACCI MAURILIO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS One year follow up of infected fetuses.1) Implementation of clinical pathways for an appropriate/comprehensive care of women infected during pregnancy and of infants with congenital infection.2) Role of innate immunity in the susceptibility to infect OSPEDALE BAMBINO GESU' Auriti Cinzia CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS microrna deregulation in atrial fibrillation: identification of pathogenetic mechanisms and of peripheral blood biomarkers SAN DONATO butera gianfranco CLI Cardiovascular and Electrical Signaling, Ion Transport, and Arrhythmias ESTA Cytoreduction and Hipec in the treatment of OvaRIaN cancer CHORINE StudyStage IIIC unresectable epithelial ovarian/tubal cancer with partial or complete response after 1st line neoadjuvant chemotherapy (3 Lombardia ANSALONI LUCA CLI Oncology 2 Oncology CONC cycles CBDCA+Paclitaxel): a phase 3 pros Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer s Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an in vitro model of anesthetic inducing oligomerization NEUROLESI Fodale Vincenzo Brain Disorders and and CNN Pagina 64 di 167

65 Relationship between biomarkers, diastolic left ventricular recoil reserve measurement and ventriculararterial coupling to improve diagnosis and risk stratification in diastolic heart failure. Umbria Carluccio Erberto CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Whole genome scanning in AML to develop a better prognostic stratification and personalized risk based therapies SAN MATTEO BERNASCONI PAOLO Oncology 2 Cancer Biomarkers CBSS Taxi Doctor Cabrini Luca CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Treatment optimization of recurrent glioblastoma Emilia Romagna Brandes Alba CLI Oncology 2 Oncology CONC A COMMON SCORE TO EVALUATE CLINICAL AND LOGICAL ASPECTS OF ACUTE MYELOID LEUKEMIA (AML) IN ELDERLY PATIENTS AIMED TO ENSURE HOMOGENEOUS DIAGNOSTIC AND TREATMENT CRITERIA IN THE HAEMATOLOGY UNITS IN EMILIA ROMAGNA. Emilia Romagna crugnola monica CLI Oncology 2 Oncology CONC Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial Piemonte Bo Simona CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP ROLE OF MATERNAL INTRAPARTUM ANTITIC PROPHYLAXIS ON NEONATAL GUT MICROTA FLORA AND ONSET OF LATER ALLERGY RELATED DISEASES. Lombardia Zuccotti Gian Vincenzo CLI Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP MOLECULAR EVENTS IN MELANOMA PROGRESSION: REGULATION OF AP 2 TARGET GENES AND INVOLVEMENT IN TUMOR GROWTH AND METASTASIS. Piemonte BERNENGO MARIA GRAZIA Oncology 2 Cancer Biomarkers CBSS Pagina 65 di 167

66 Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution Filippi Massimo CLI Brain Disorders and and CNN Amantadine treatment for pathological gambling FATEBENEFRATELLI Onofrj Marco CLI Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS CLINICAL AND SOCIAL GOVERNANCE OF MIGRANTS OF MEDITERRANEAN Sicilia Pasta Linda CLI Healthcare Delivery and Community Level Health Promotion CLHP Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections. Istituto Superiore di Sanita' Baldassarri Lucilla Bioengineering Sciences and Technologies Nanotechnology NANO The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiency on alterations of bone mineral metabolism in young women with chronic bowel diseases: a pilot study. AUXOLOGICO VAI Silvia CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification MONZINO Sironi Luigi Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease. Istituto Scienze Neurologiche Parchi Piero Brain Disorders and and CNN CCRL2 as a new therapeutic target in rheumatoid arthritis HUMANITAS Sozzani Silvano Immunology Hypersensitivity, Autoimmune, and Immune Pagina 66 di 167

67 FROM HUMAN TO CANINE. SERUM TUMOUR MARKERS EXPRESSION IN MAMMARY CANCER: NEW PERSPECTIVE IN VETERINARY ONCOLOGY? Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Manuali Elisabetta Veterinary Animal Health ANHE The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role MONZINO Banfi Cristina Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Risk benefit assessment of cardiovascular drug use in elderly and very old patients affected by cardiovascular disease: a multicentre pharmaco epidemiological study Lazio Davoli Marina CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Imaging and molecular analysis of brain inflammation in depression: a translational approach MORESCO Rosa Maria Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA THE IMPACT OF EPIGENOMICS ON THE IDENTIFICATION OF NEW PROGNOSTIC MARKERS AND INNOVATIVE THERAPIES IN NEUROENDOCRINE TUMORS (NETs) AUXOLOGICO VITALE GIOVANNI Oncology 1 Basic Cancer Genetics CG MULTI CENTER STUDY ON METABOLIC COMPLICATIONS IN HIV INFECTED PEDIATRIC PATIENTS IMMUNE RESPONSE AND VDRS POLYMORPHISMS IN INFANTS AND CHILDREN EARLY SUPPLEMENTED WITH ORAL CHOLECALCIFEROL. Lombardia Giacomet Vania CLI AIDS and Related Research AIDS Studies and Epidemiology ACE Lombardia Pogliani Laura CLI Immunology Innate Immunity And Inflammation III Early integration of palliative care with standard oncologic care in advanced non small cell lung cancer. A prospective, multi center observational study to evaluate how this approach impact on patient s survival and quality of life with an additional ana I. O. V. Bonetti Andrea CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Breast Cancer targeting through innovative drug delivery systems. IRCCS AOU San Martino IST (Genova) Rosano Camillo Oncology 2 Drug Discovery and Molecular Pharmacology DMP Pagina 67 di 167

68 ROLE OF COLECALCIPHEROL IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT. Piemonte ISAIA giovanni carlo CLI Brain Disorders and and CNN Intrabone cord blood transplantation for hematological malignancies Emilia Romagna BONIFAZI FRANCESCA CLI Vascular and Hematology Hematopoiesis HP Role of Copy Number Variations in determining the individual susceptibility to essential hypertension AUXOLOGICO Zanchetti Alberto Cardiovascular and and Integrative Cardiovascular Sciences CICS A CORRELATIVE, NEUROIMMUNOVIROLOGICAL AND MRI ANALYSIS OF PROGNOSTIC MARKERS IN ALZHEIMER'S DISEASE DON GNOCCHI CLERICI MARIO Brain Disorders and Neuroimmunology and Brain Tumors CNBT Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer poly peptide vaccine directed against the thymidylate synthase enzyme. Toscana CUSI MARIA GRAZIA CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Physical activity as a strategic measure to reduce drugs consumption and interactions in elderly patients with cardiovascular disease and comorbidity Molise FERRARA NICOLA CLI Healthcare Delivery and Community Level Health Promotion CLHP Defining non invasive outcome measures and elucidating the molecular mechanisms underlying muscle degeneration in Facioscapulohumeral muscular dystrophy DON GNOCCHI Ricci Enzo Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Estimation of cured patients among persons living with neoplasms C.R.O. AVIANO Dal Maso Luigino Population Sciences and Epidemiology Epidemiology of Cancer EPIC Differentiating Ehrlich carcinoma cells and reducing ascites in rats in vivo. A preclinical study. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Giuliani Livio Oncology 1 Basic Tumor Progression and Metastasis TPM2 Pagina 68 di 167

69 Next Generation Sequencing approaches for Diagnostics of common and rare genetic diseases NEUROMED D'ESPOSITO MAURIZIO CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Thematic network on Bovine Diarrhoea Virus (BVDV) to improve tools and strategies for BVDV control in Italy Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche De Mia Gian Mario Veterinary Animal Health ANHE Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Mazzini Letizia Molecular, Cellular, and Developmental Neurodifferentiation, Plasticity, and Regeneration NDPR White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA Prudente Sabrina Genes, Genomes and Genetics Genetics of Health and Disease GHD A combination of surveys, spatial analyses and molecular epidemiology to get an insight of pre harvest risks from Shiga toxin producing Escherichia coli. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta RU GIUSEPPE Veterinary Food Safety FOSA NEW MOLECULES AS DISEASE MODIFYING DRUGS FOR OSTEOARTHRITIS TREATMENT Istituto Superiore di Sanita' Scotto d'abusc Anna Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Evaluation of circulating endothelial cells as a biomarker of endothelial damage in patients undergoing allogeneic stem cells transplantation (allobmt): correlation with graft versus host disease (GVHD) onset. Lombardia Almici Camillo Vascular and Hematology Hematopoiesis HP Impact of diet in shaping gut microbiota revealed by a prospective dietetic study of African children consuming a Western diet DE BELLIS Riezzo Giuseppe CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP Learn and live: extended training for a safer hospital HUMANITAS MARCONI MANUEL CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 69 di 167

70 POST TRANSCRIPTIONAL REGULATION AND MITOCHONDRIAL LOCALIZATION OF BRCA1 IN HUMAN BREAST CANCER ONCOLOGICO DI BARI Tommasi Stefania Oncology 1 Basic Molecular Oncogenesis MONC A MULTIDISCIPLINARY EMERGENCY APPROACH TO IMPROVE QUALITY OF CARE AND REDUCE POST TRAUMATIC STRESS DISORDER IN CHILDREN Emilia Romagna sandra morselli CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Molecular mechanisms of neutrophil recruitment as novel targets to curb lung damage in cystic fibrosis. Abruzzo Evangelista Virgilio Cardiovascular and Lung Injury, Repair, and Remodeling LIRR Cheyne Stokes respiration in heart failure patients: from the identification of individual pathophysiological mechanisms to individualized treatment MAUGERI Pinna Gian Domenico Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Preemptive donor lymphocyte infusions guided by realtime PCR host donor microchimerism for prevention of leukemia relapse after haploidentical stem cell transplantation Fleischhauer Katharina CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio Cardillo Carmine CLI Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Effects of early microbiological diagnosis (molecular tests vs standard) on length of stay in Intensive Care Unit Emilia Romagna Capuzzo Maurizia CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Investigating Huntington disease stage related biomarkers in the nervous and cardiovascular systems NEUROMED Squitieri Ferdinando CLI Brain Disorders and and CNN Metformin plus standard chemotherapy: a new weapon to target tumor initiating cells in colorectal cancer treatment and prevention ISTITUTO TUMORI MILANO Gariboldi Manuela Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 70 di 167

71 Imaging in clinical MR spectroscopy: reconstruction of high spatial resolution metabolic maps Toscana Passeri Alessandro Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche Liguori Rocco Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC Salivary gland tumours: molecular and molecularcytogenetic studies to identify diagnostic/prognostic markers and risk factors Istituto Superiore di Sanita' Floridia Giovanna Genes, Genomes and Genetics Genetics of Health and Disease GHD Hypothesized points of convergence in the pathogenesis of Alzheimer's disease, frontotemporal lobar dementia, schizophrenia and bipolar disorder with therapeutic implications SMERALDI ENRICO Brain Disorders and and CNN Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneurons development. de Curtis Ivan Molecular, Cellular, and Developmental Neurodifferentiation, Plasticity, and Regeneration NDPR Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area DE BELLIS Osella Alberto Rubén Population Sciences and Epidemiology Kidney, Nutrition, Obesity and Diabetes KNOD Exploring the interactome of the high risk Human Papillomavirus oncoproteins to understand and dismantle its oncogenic power REGINA ELENA Paggi Marco giorgio Oncology 1 Basic Cancer Etiology CE strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Piemonte INGHIRAMI GIORGIO CLI Oncology 2 Oncology CONC Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Istituto Superiore di Sanita' Superti Fabiana Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Pagina 71 di 167

72 Toward the development of an in vitro test for ALS: largescale validation of PBMC protein biomarkers Lombardia Bonetto Valentina CLI Brain Disorders and and CNN Protective ventilatory strategy in severe brain injured patients: a randomized control trial Piemonte mascia luciana CLI Cardiovascular and Lung Injury, Repair, and Remodeling LIRR Biological foundations of self control and potential diagnostic implications Istituto Superiore di Sanita' Vitale Augusto Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health MESH DISCHARGE FROM FORENSIC MENTAL HOSPITALS, COMMUNITY TENURE, AND RISK OF RECIDIVISM: A PROSPECTIVE FOLLOW UP STUDY Lombardia PERCUDANI MAURO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Transgenic zebrafish model to visualize proliferation in vivo. REGINA ELENA Manni Isabella Cell Biology Cellular Signaling and Regulatory Systems CSRS Interactive mapping of pathways and targets in renal cancers ISTITUTO TUMORI MILANO Bongarzone Italia CLI Oncology 2 Developmental Therapeutics DT Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling Lombardia Chiesa Roberto Brain Disorders and Cell Death in CDIN alpha7 nachr status and response to donepezil in AD patients SAN RAFFAELE PISANA Russo Patrizia CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab I. O. V. FAVARETTO ADOLFO CLI Oncology 2 Cancer Biomarkers CBSS Healthy diet: evaluation of antioxidant capacity of a weekly selected menu in elderly people, and factors affecting its strength. Emilia Romagna franchi fabrizio CLI Healthcare Delivery and Community Level Health Promotion CLHP Pagina 72 di 167

73 Adoptive therapy with tolerogenic T regulatory type 1 (Tr1) cells in islet transplanted T1D patients Roncarolo Maria Grazia Immunology Transplantation, Tolerance and Tumor Immunology TTT Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO Pierotti Marco Alessandr Oncology 2 Cancer Biomarkers CBSS Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. Galli Rossella Brain Disorders and Developmental Brain Disorders DBD Proteomics of benign and malignant parathyroid tumors: identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer Toscana Cetani Filomena Oncology 1 Basic Cancer Genetics CG REGISTRY FOR HEREDITARY AND FAMILIAL BREAST CANCER AND IDENTIFICATION OF NEW DISEASE CAUSING GENES AND REGIONS Lombardia CAZZANIGA MARINA ELEN CLI Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] Rethinking neuroinflammation in sporadic AD: exploring novel therapeutic and prognostic tools Istituto Superiore di Sanita' Minghetti Luisa Brain Disorders and and CNN IMPLEMENTATION AND TESTING OF AN E HEALTH BASED SYSTEM FOR EARLY DIAGNOSIS AND INTERVENTION ON SPECIFIC READING DISORDERS MEDEA Lorusso Maria Luisa CLI Healthcare Delivery and Biomedical Computing and Health Informatics BCHI Multidisciplinary study of the motor function in obese subjects with Prader Willi syndrome: from molecular control to muscular performance. AUXOLOGICO Grugni Graziano CLI Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Pagina 73 di 167

74 Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma and in liver regeneration: mirnome and proteome analysis in experimental and clinical settings Istituto Superiore di Sanita' RUGGIERI ANNA Oncology 2 Cancer Biomarkers CBSS MOLECULAR AND FUNCTIONAL PROFILES OF NON SELF SUFFICIENCY ELDERLY:FROM DIAGNOSIS TO CARE MODELS Calabria Ferrante Pasquale CLI Healthcare Delivery and Biomedical Computing and Health Informatics BCHI Bio Molecular markers in the secondary prevention, diagnosis, prognosis and personalized therapy of hepatocellular carcinoma. Veneto Farinati Fabio Oncology 2 Cancer Biomarkers CBSS METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER SDN Mancini Marcello CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Preliminary Study on Bone Tissue Regeneration in Massive Loss of Substance in MusculoSkeletal Oncology REGINA ELENA Chichierchia Giuseppina Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE Study of the interaction between polyomavirus JC (JCV) and stem cells Toscana Maggi Fabrizio Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity MAUGERI Chiovato Luca CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Role of host pathogen interplay in genital cancer pathogenesis: gene mutations and nucleotide polymorphisms as determinants of cancer susceptibility and response to therapy PASCALE Tornesello Maria Lina Oncology 1 Basic Cancer Genetics CG Pagina 74 di 167

75 Development of innovative rapid screening methods of corticosteroids agents in cattle as growth promoters using MEA and an enhanced histopathological approach Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Bozzetta Elena Veterinary Food Safety FOSA Antiprotons vs photons: a new hypothesis for radiotherapy ONCOLOGICO DI BARI Paradiso Angelo Oncology 2 Radiation Therapeutics and Biology RTB Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study Istituto Superiore di Sanita' Grigioni Mauro CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Palmirotta Raffaele Veterinary Animal Health ANHE mir34a: clarifying its value in prognosis and therapy of Ewing s sarcoma. RIZZOLI Manara Maria Cristina Oncology 1 Basic Molecular Oncogenesis MONC Effects of an educational intervention for reducing inappropriate prescribing in elderly exposed to polypharmacy in general practice Lombardia Nobili Alessandro CLI Healthcare Delivery and Health Services Organization and Delivery HSOD VALIDATION OF NANOPARTICLES FOR DRUG DELIVERY IN HEREDITARY NEUROMUSCULAR DISEASES TREATMENTS OSPEDALE BAMBINO GESU' Ferlini Alessandra Molecular, Cellular, and Developmental Drug Discovery in the Nervous System ZRG1 MNPS IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING GASLINI Zara Federico Genes, Genomes and Genetics Genetics of Health and Disease GHD Readthrough of Premature Termination Codons to treat Kabuki syndrome CASA SOLLIEVO SOFFERENZA Merla Giuseppe Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Pagina 75 di 167

76 PRECLINICAL DEVELOPMENT OF NOVEL SMALL ANDROGEN RECEPTOR MODULATING MOLECULES (SARMS) IN EXPERIMENTAL HUMAN PROSTATE CANCER MODELS Emilia Romagna Tesei Anna Oncology 2 Drug Discovery and Molecular Pharmacology DMP IGF PATHWAY IN NEUROENDOCRINE TUMORS: PROGNOSTIC ROLE AND NOVEL TARGET THERAPY SDN Di Somma Carolina CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology MCE TESTING A MODEL FOR THE ASSESSMENT OF APPROPRIATENESS OF THE USE OF DRUGS, WITH ACTIONS TO SUPPORT HEALTH AND SOCIAL CARE TO FRAIL ELDERLY PEOPLE IN THE HOME VIA HOME DELIVERY OF THERAPY AND CONSEQUENT REDUCTION IN PHARMACEUTICAL EXPENDITURE WITHIN THE NA Marche GIANNI GENGA CLI Healthcare Delivery and Health Services Organization and Delivery HSOD and molecular mechanisms of accelerated aging in dialysis patients. Abruzzo Maccarone Daniela Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD IDENTIFICATION OF NEW GENETIC, PROTEIC AND METABOLIC MARKERS TO DISTINGUISH BENIGN FROM MALIGNANT THYROID CELLS. Toscana agretti patrizia Genes, Genomes and Genetics Genetics of Health and Disease GHD Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana MORRONE AMELIA CLI Genes, Genomes and Genetics Gene Therapy and Inborn Errors GTIE Special Emphasis Panel CLINICAL IMPACT OF CIRCULATING TUMOR CELLS AND MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF SOLID TUMORS Toscana PAZZAGLI MARIO CLI Oncology 2 Cancer Biomarkers CBSS Innovative analytical procedures and rapid diagnostic methods for the assessment of hygienic sanitary status of the fishery and mariculture production chains for the presence of emerging organic and inorganic micropollutants and emerging zoonotic pathoge Istituto Zooprofilattico Sperimentale del Mezzogiorno ESPOSITO MAURO Veterinary Food Safety FOSA Pagina 76 di 167

77 CDKL5 variant of Rett s syndrome: clinical phenotype and effects of mutations on the development of the central nervous system in view of future therapeutic approaches Istituto Scienze Neurologiche Parmeggiani Antonia Brain Disorders and Developmental Brain Disorders DBD Prospective Study on infectious complications in patients receiving biological drugs, either monoclonal antibodies or TNF alpha antagonists. Emilia Romagna Mussini Cristina CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia Romagna Federico Massimo CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders SANTA LUCIA Galati Gaspare Integrative, Functional, and Cognitive Cognitive COG PanCareSurFupPanCare Childhood and Adolescent Cancer Survivor Care and Follow up Studies, Italian branch Piemonte merletti franco Oncology 2 Oncology CONC ABCB1/P glycoprotein expression: a biological stratification of the risk in patients with non metastatic osteosarcoma of the extremity. An Italian Sarcoma Group prospective study (ISG/OS 2). Emilia Romagna Ferrari Stefano CLI Oncology 2 Cancer Biomarkers CBSS Development of beta cell specific aptamers as novel diagnostic and therapeutic tools for diabetes mellitus. Malosio Maria Luisa Surgical Sciences, Biomedical Imaging, and Bioengineering Molecular Imaging and Probe Development CMIP Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Baldini Antonio Cardiovascular and Cardiovascular Differentiation and Development CDD HIV patient s adherence: a study of predictive factors Lombardia vegni Elena Anna Mari CLI AIDS and Related Research Behavioral and Social Consequences of HIV/AIDS BSCH Pagina 77 di 167

78 Prediction of response to targeted therapies in esophageal adenocarcinoma patients using an endoscopic biopsies xenograft rat model. I. O. V. ANCONA ERMANNO CLI Oncology 2 Cancer Biomarkers CBSS Staphylococcal enterotoxin in traditional raw ewe milk Pecorino cheese: risk assessment and proteomic characterization Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Pezzotti Giovanni Veterinary Food Safety FOSA Biomolecular Markers Involved in the Development of Hepatitis Virus Infections Associated Lymphomas: A Multicentric Case Control Study C.R.O. AVIANO Talamini Renato Oncology 2 Cancer Biomarkers CBSS The mevalonate (Mev) pathway as a common metabolic target to modulate the susceptibility of Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) tumor cells to chemotherapy, environmental prosurvival signals, and immune recognition by Vgamma9Vde Piemonte Massaia Massimo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pediatric headaches: utility of "RED FLAGS" in the use of CT and MRI Sicilia RAIELI VINCENZO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Toscana Annunziato Francesco Immunology Hypersensitivity, Autoimmune, and Immune Defective DNA polymerase beta isoforms as protective factors against Alzheimer's disease OASI MARIA S.S. Bosco Paolo Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Studying the tumour microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma: the role of Mesenchymal stem cells C.R.O. AVIANO Aldinucci Donatella Oncology 1 Basic Tumor Microenvironment TME Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis Candiani Massimo Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER Pagina 78 di 167

79 Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) Veneto Semenzato Gianpietro Vascular and Hematology Hematopoiesis HP A multidisciplinary approach to personalized medicine in CRC Sicilia Cappellani Alessandro CLI Oncology 2 Developmental Therapeutics DT Circulating tumor cells, with stem like and/or epithelialmesenchymal transition features, detectable in peripheral blood of breast cancer patients: biological and clinical significance ISTITUTO TUMORI MILANO Daidone Maria Grazia Oncology 2 Cancer Biomarkers CBSS Epigenetic determinants of psoriasis and psoriatic arthritis: diagnostic and prognostic values of DNA methylation patterns Emilia Romagna Salvarani Carlo Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Prevention and treatment of atherosclerotic vascular disease in people living in the same geographical area. Veneto LOTTO VALENTINA CLI Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis Rovere Querini Patrizia Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' Barillari Giovanni Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenic brain malformation CARLO BESTA Battaglia Giorgio Brain Disorders and Acute Neural Injury and Epilepsy ANIE THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES SAN DONATO Meola Giovanni CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME Pagina 79 di 167

80 IATRIS neuroscience: a critical reassessment of preclinical studies in neurologic diseases. Istituto Superiore di Sanita' Malchiodi Albe Fiorella Brain Disorders and and CNN User participation in payment of health treatments(copayement) Agenzia per i Servizi Sanitari Regionali cislaghi cesare CLI Healthcare Delivery and Health Services Organization and Delivery HSOD CHANGES IN STRUTTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA d'avella Andrea Integrative, Functional, and Cognitive Sensorimotor Integration SMI Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS TOSETTI MICHELA Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Alpha Synuclein as a possible predictive and prognostic marker for Parkinson's Disease Istituto Superiore di Sanita' Confaloni Annamaria Brain Disorders and and CNN Food irradiation: quality and detection of plant origin food with health benefits Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Boniglia Concetta Veterinary Food Safety FOSA AN INNERVATED TISSUE ENGINEERING APPROACH TO RECONSTRUCT THE ESOPHAGUS Veneto COZZI Emanuele Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Response Evaluation Criteria in Solid Tumors: a comparative study between Imaging and Biomolecular indices Sicilia Blasi Livio CLI Oncology 2 Cancer Biomarkers CBSS Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy Staudacher Carlo CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Pagina 80 di 167

81 Advanced personal and environmental teledosimetry system Toscana TRAINO ANTONIO Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Understanding the adaptive immune response defects of WHIM syndrome patients HUMANITAS Kallikourdis Marinos Immunology Hypersensitivity, Autoimmune, and Immune Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Emilia Romagna Fanti Stefano CLI Oncology 2 Cancer Biomarkers CBSS Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA TOZZI ALESSANDRO Brain Disorders and Cell Death in CDIN CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Identification of immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease Istituto Superiore di Sanita' Fantuzzi Laura AIDS and Related Research AIDS Immunology and Pathogenesis AIP Istituto Superiore di Sanita' Viora Marina Immunology Innate Immunity And Inflammation III BCL XL GENE EXPRESSION QUANTIFICATION FOR MINIMAL RESIDUAL DISEASE DETECTION IN PMF: A NEW MOLECULAR MARKER TO PREDICT EARLY RELAPSE IN JAK2V617F NEGATIVE PATIENTS. IRCCS AOU San Martino IST (Genova) Bacigalupo Andrea Oncology 2 Cancer Biomarkers CBSS Early onset anorexia nervosa: the role of hyperactivity as predictor of outcome STELLA MARIS Maestro Sandra CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO SALUTE CKD (SALt lowering by Urine sodium selfmeasurement Trial in Chronic Kidney DiseasE) Calabria Zoccali Carmine CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO THE ROLE OF EARLY SCREENING IN PERINATAL DEPRESSION Toscana mauro mauri CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Pagina 81 di 167

82 Vaccination strategies to prevent infections in splenectomized patients SAN MATTEO Corazza Gino Roberto CLI Immunology Vaccines Against Microbial Diseases VMD Screening of children at risk for language and communication disorders Lazio Pasqualetti Patrizio CLI Biobehavioral and Behavioral Processes Language and Communication LCOM Therapeutic heart rate lowering in coronary artery disease patients and endothelial shear stress: the likely beneficial link MAUGERI Ferrari Roberto Cardiovascular and and Integrative Cardiovascular Sciences CICS Use and integration of clinical and administrative databanks to evaluate the quality and continuity of care processes for epidemiological study and for health planning for patients affected by heart brain vascular diseases. Lombardia BARBIERI Pietro CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Studies of the pathogenic mechanisms and zoonotic role of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Petrini Stefano Veterinary Animal Health ANHE Nd:YAG laser ablation for mininvasive endoscopic treatment of pancreatic neoplastic lesions: from animal model to human application Lazio Di Matteo Francesco Maria Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Individual risk for lung cancer and low dose CT Scan screening for occupationally ex exposed to asbestos. Toscana Paci Eugenio CLI Oncology 2 Oncology CONC Genetic polymorphisms and noninvasive scores for screening patients with progressive non alcoholic fatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Musso Giovanni Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Neuroplasticity, rehabilitation and work ability Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Iavicoli Sergio Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Pagina 82 di 167

83 Nanoparticle delivered gene therapy to overcome remyelination failure resulting from blocked mature oligodendrocytes in multiple sclerosis like disease CARLO BESTA Kerlero de Ros Nicole Brain Disorders and Neuroimmunology and Brain Tumors CNBT Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multi pathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie Capelli Gioia Veterinary Animal Health ANHE Neural Stem Cell mediated Therapy of Amyotrophic Lateral Sclerosis CASA SOLLIEVO SOFFERENZA Vescovi Angelo Luigi Brain Disorders and and CNN Hypoxia, inflammation and stem cells in cancer progression SAN RAFFAELE PISANA Russo Matteo Antonio Oncology 1 Basic Tumor Progression and Metastasis TPM Study on transmission patterns of Salmonella enterica serovar 4, 5, 12:i: within pig units Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Magistrali Chiara Francesc CLI Veterinary Animal Health ANHE Post Transplant Hematopoiesis: a model to understand the mechanisms of hematopoietic stem cells (HSC) aging and the interactions between HSC and microenvironment. IRCCS AOU San Martino IST (Genova) Frassoni Francesco Vascular and Hematology Hematopoiesis HP Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation Sicilia Conaldi Pier Giulio Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB SAFE FISH: safety and nutritional value assessment of Italian marine farmed fish Istituto Zooprofilattico Sperimentale della Sicilia Di Bella Calogero Healthcare Delivery and Healthcare Delivery and Small Business SBHD Resistin as a biomarker of coronary artery disease, major cardiovascular events and all cause mortality in patients with type 2 diabetes. CASA SOLLIEVO SOFFERENZA Menzaghi Claudia Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Pagina 83 di 167

84 EXPERIMENTAL MODELLING OF TUMOR RELAPSE FOR THE DESIGN AND PRE CLINICAL VALIDATION OF COMBINATORIAL APPROACHES OF TARGETED THERAPY IN ORAL CAVITY CARCINOMAS Emilia Romagna Sesenna Enrico Oncology 2 Developmental Therapeutics DT Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia Pennisi Giovanni CLI Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Identification of EphA3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutic approach with a specific monoclonal antibody CROB Cilloni Daniela Oncology 1 Basic Tumor Cell Biology TCB Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severe Gram positive infections Toscana Di Paolo Antonello CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Predictive biomarkers of melanoma progression and clinical response to chemo immunotherapeutic therapies using new medical imaging approaches SAN GALLICANO Catricalà Caterina Oncology 2 Cancer Biomarkers CBSS Co Amplification of the ERBB2 and RARA genes in breast cancer: a potential target for retinoid based therapy MAUGERI Zambelli Alberto CLI Oncology 2 Developmental Therapeutics DT Study of a method of calculation of the optimum radionuclide activity in radioimmunotherapy of tumors based on the reduction of the target mass Veneto FERDEGHINI MARCO Oncology 2 Radiation Therapeutics and Biology RTB Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Emilia Romagna Gordini Giovanni CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE FACES IV: A DIAGNOSTIC INSTRUMENT TO EVALUATE FAMILY FUNCTIONING IN A SAMPLE OF PATIENTS IN THE PEDIATRIC AGE OSPEDALE BAMBINO GESU' Tortolani Daniela CLI Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD Pagina 84 di 167

85 Modulation of mir 221 and mir 222 in skeletal muscle cells: impact on muscle physiology and pathology Istituto Superiore di Sanita' Falcone Germana Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Analysis of specific markers of mental health, after time by admissions to a hospital, for onset of psychiatric disorders in developmental age. Sicilia Ragusa Donatella CLI Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD MSC based therapy for the bone marrow and solid organs transplantations Lombardia Introna Martino CLI Oncology 2 Drug Discovery and Molecular Pharmacology DMP Extraneuronal airway cholinergic system and ß2ARs function in stable COPD and control subjects Emilia Romagna Caramori Gaetano Cardiovascular and Lung Cellular, Molecular, And Immunobiology LCMI Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. MAGGIORE Valenza Franco CLI Cardiovascular and Lung Injury, Repair, and Remodeling LIRR CLINICAL AND LOGICAL INVESTIGATIONS IN PATIENTS WITH PRIMARY PLASMA CELL LEUKEMIA RECEIVING A TRIPLE COMBINATION OF BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE AS FIRST LINE TREATMENT CROB Musto Pellegrino CLI Oncology 2 Oncology CONC Internet addiction disorder in adolescents: identification of possible biological and personality markers Toscana Marazziti Donatella Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS Randomized controlled trial on the role of telemonitoring for the management of chronic obstructive pulmonary disease (COPD) Sicilia DI MARIA GIUSEPPE CLI Cardiovascular and Small Business Activities ZRRS Molecular determination of Salmonella serovars by using microsphere based suspension array Istituto Zooprofilattico Sperimentale delle Venezie Barco Lisa Veterinary Food Safety FOSA Pagina 85 di 167

86 Necdin role in myogenic stem cells self renewal and maintenance for the repair of the dystrophic muscle Brunelli Silvia Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Therapeutic strategies in refractory chronic daily headache: A multicenter, open, randomized, controlled trial. Istituto Scienze Neurologiche Cevoli Sabina CLI Emerging Technologies and Training in s Pharmacology and Diagnostics for Neuropsychiatric Disorders and Neural Systems Small Business SBPD HYPOPLASTIC LEFT HEART SYNDROME (HLHS): FROM DISCOVERY OF GENETIC BASIS TO MOLECULAR CLASSIFICATION FOR THERAPEUTIC STRATEGIES Lombardia Iascone Maria Genes, Genomes and Genetics Genetics of Health and Disease GHD Nanotecnology based drug delivery : new generation nanovector for drug delivery in human bone diseases. GALEAZZI Mariotti Massimo Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD BREAST CANCER RISK AND DIETARY MICRONUTRIENTS ASSOCIATED WITH ONE CARBON METABOLISM PATHWAY IN BRCA1/2 SUBJECTS: AN OBSERVATIONAL STUDY C.R.O. AVIANO Ettore Bidoli Population Sciences and Epidemiology Epidemiology of Cancer EPIC Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS Lombardia Pogliani Enrico Maria Interdisciplinary Molecular Sciences and Training Fellowship: Oncological Sciences F Biomarkers for optimization of Attention Deficit Hyperactivity Disorder (ADHD) pharmacological therapy FATEBENEFRATELLI Scassellati Catia Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities CPDD Development of a DNA microarray for a rapid and reliable detection of pathogens in ready to eat foods. Istituto Zooprofilattico Sperimentale del Mezzogiorno AMOROSO MARIA GRAZIA Veterinary Food Safety FOSA Autophagy inhibition in chronic myelogenous leukemia stem cells: the way to the cure? IRCCS AOU San Martino IST (Genova) CARELLA ANGELO MICH Vascular and Hematology Hematopoiesis HP Pagina 86 di 167

87 Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. SAN RAFFAELE PISANA Palma Eleonora Brain Disorders and Acute Neural Injury and Epilepsy ANIE The role of oxytocin in anxiety disorders FATEBENEFRATELLI Dell'Osso Liliana Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Bernardi Bruno Brain Disorders and and CNN "Distribution of allelic polymorphism (TAAA)n in the Sex Hormone Binding Globulin (SHBG) gene in breast cancer patients with or without hormone therapy:relations with SHBG plasma levels and nutrictional factors". ONCOLOGICO DI BARI QUARANTA MICHELE CLI Genes, Genomes and Genetics Genetic Variation and Evolution GVE The SHARP Study: Simultaneous Hybrid Revascularization by Carotid Stenting and Coronary Artery Bypass Grafting Lazio Nardi Paolo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Role of novel modulators of ectopic mineralization during aortic valve disease progression Mesenchymal stem cells and T cells in head and neck squamous cell carcinoma: a unified vision of the tumoral stroma for the identification of new prognostic markers and possible therapeutical targets. Veneto Pauletto Paolo Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Toscana Liotta Francesco Immunology Transplantation, Tolerance and Tumor Immunology TTT Rehabilitation of somatic deficits after stroke through training and non invasive brain stimulation AUXOLOGICO Vallar Giuseppe CLI Integrative, Functional, and Cognitive Somatosensory and Chemosensory Systems SCS Pagina 87 di 167

88 Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. SAN RAFFAELE PISANA Ciriolo Maria Rosa Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Functional modifications of Substantia nigra pars reticulata neurons firing upon high frequency stimulation in the Subthalamic nucleus: a parallel investigation on Parkinson s disease patients treated with Deep Brain Stimulation and on rat midbrain slice SANTA LUCIA Berretta Nicola CLI Brain Disorders and and CNN Combined molecular and functional studies to identify novel targets for neuroprotection against brain and spinal cord damage: from bench to bedside. Toscana Mannaioni Guido Brain Disorders and Cell Death in CDIN EXPERIMENTAL AND CLINICAL USE OF STEM CELLS IN THE TREATMENT OF HEART FAILURE Sicilia Carruba Giuseppe Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF EFFECT OF DEACETILASE INHIBITORS ON EPIGENETIC BALANCE OF E CADHERIN: NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Piemonte Fortunati Nicoletta Oncology 1 Basic Tumor Progression and Metastasis TPM Striatal synaptic plasticity in experimental models of Parkinson's disease with different degrees of dopamine denervation: molecular mechanisms and therapeutics implications SANTA LUCIA Calabresi Paolo Brain Disorders and and CNN Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development Lombardia CETIN IRENE Biology of Development and Aging Aging Systems and Geriatrics ASG Phenotypes in Dislexia with genetic alteration: sensory and neuronal deficits STELLA MARIS Morrone Maria Concetta CLI Integrative, Functional, and Cognitive Central Visual Processing CVP Ageing at work: promoting health and safety of ageing workers according to changes of demography, labour market and social policies. MAGGIORE Costa Giovanni Risk, Prevention and Health Behavior Psychosocial Development, Risk, and Prevention PDRP Pagina 88 di 167

89 Role of autophagy in the control of regulatory T cells and autoimmunity SANTA LUCIA Borsellino Giovanna Immunology Hypersensitivity, Autoimmune, and Immune Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Toscana CORRADETTI RENATO Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity SAN RAFFAELE PISANA Tafani Marco Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Sentinel animals to monitor pollution around the former Balangero asbestos mine Piemonte Mirabelli Dario Population Sciences and Epidemiology Epidemiology of Cancer EPIC EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF ERYTHRODERMIC CUTANEOUS T CELL LYMPHOMA: CLINICAL ACTIVITY, TOXICITIES, QUALITY OF LIFE IMPROVEMENT AND RESPONSE ASSOCIATED LOGICAL MARKERS Piemonte QUAGLINO PIETRO CLI Oncology 2 Oncology CONC Hydrogen sulphide (H2S) as a novel player in endothelial dysfunction associated to hypertension SAN RAFFAELE PISANA Bucci Mariarosaria Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Calcific arteriopathy in chronic kidney disease: genetic determinants, molecular biology and clinical markers Vezzoli Giuseppe Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of associated carcinogenic risk Istituto Superiore di Sanita' Pietraforte Donatella Oncology 1 Basic Cancer Etiology CE Pagina 89 di 167

90 Echografic detection of Hepatocellular carcinoma with a 3 dimensional ultrasound with contrast media in cirrhotic patients. Emilia Romagna FORNARI FA CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology BMIT Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in tumor cells: breast cancer targeting and biodistribution Lombardia CORSI FA Bioengineering Sciences and Technologies Nanotechnology NANO Electronic health databases as a source of reliable information for effective health policy Puglia Trerotoli Paolo CLI Healthcare Delivery and Biomedical Computing and Health Informatics BCHI MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII ISOLATES BY RAPD AND MLVA ANALYSES Istituto Zooprofilattico Sperimentale del Mezzogiorno BORRIELLO GIORGIA Veterinary Animal Health ANHE Novel assays for the diagnosis of scleroderma Marche Gabrielli Armando Immunology Hypersensitivity, Autoimmune, and Immune Generic substitution of antidepressant drugs NEUROLESI Spina Edoardo CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA How innate immunity enhances aggressiveness of colorectal carcinoma in HIV individuals Alfano Massimo AIDS and Related Research AIDS Associated Opportunistic Infections and Cancer AOIC Study of bacterial, parasitic and viral pathogens found in animal and vegetables food matrices, currently not covered by the national and European laws, with particular reference to the list of zoonotic agents. Istituto Zooprofilattico Sperimentale della Sicilia Caracappa Santo Veterinary Food Safety FOSA Continuity of mental disorders from childhood to early adulthood in Emilia Romagna and Piemonte: comparison with the Danish population Emilia Romagna STAGI PAOLO CLI Risk, Prevention and Health Behavior Psychosocial Development, Risk, and Prevention PDRP Pagina 90 di 167

91 Personalising curative treatment decision for locally advanced head and neck cancer through identification of biological markers ISTITUTO TUMORI MILANO Licitra Lisa Oncology 2 Cancer Biomarkers CBSS COPD global proteomics: a systems biology approach. SAN RAFFAELE PISANA Giorgianni Francesco Cardiovascular and Respiratory Integrative Biology and Research RIBT Molecular and Functional Characterization of a Polycystin/Nephrocystin Complex Boletta Alessandra Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Ferrari Maura Veterinary Animal Health ANHE Characterizations of the anti Tat adaptative immune responses in individuals naturally controlling HIV 1 replication Malnati Mauro AIDS and Related Research HIV/AIDS Vaccines VACC USE OF NEXT GENERATION SEQUENCING IN CLINICS: EVALUATION OF MODELS OF EARLY OR COMPREHENSIVE DIAGNOSIS IN A REGIONAL ASSET Liguria MELIOLI GIOVANNI CLI Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Effects of conventional rehabilitation terapy and combined restorative interventions in patients with post stroke deficits of the upper limb S.CAMILLO Dam Mauro CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP From sarcoma genetics and genomics to novel diagnostic and therapeutic strategies: a deep sequencing approach C.R.O. AVIANO Maestro Roberta Oncology 1 Basic Cancer Genetics CG Validation in genetic mouse models and in human cells of two gene therapy approaches against striatal degeneration and Huntington's Disease Brambilla Riccardo Brain Disorders and and CNN Pagina 91 di 167

92 Antimicrobial resistance and Zoonoses in Wildlife: Emerging Issues. Istituto Zooprofilattico Sperimentale del Mezzogiorno DI PRISCO FRANCESCA Veterinary Animal Health ANHE Bilateral sequential lung and pancreas transplantation and combined en bloc liver pancreas transplantation in patients with cystic fibrosis Lombardia Colledan Michele CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Adenosine receptor imaging and function, and therapeutic targets in Chronic Heart Failure Toscana CAPECCHI PIER LEOPOLD CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Role of APOBEC1 in the initiation and progression of cancer Toscana Conticello Silvestro Oncology 1 Basic Cancer Etiology CE Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO Modena Piergiorgio Oncology 2 Cancer Biomarkers CBSS Integrating ehealth technologies for Patient and General Practitioner Empowerment Lazio PILLON SERGIO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies Istituto Superiore di Sanita' VELLA STEFANO CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. MAUGERI Ghigna Claudia Oncology 1 Basic Tumor Progression and Metastasis TPM A perspective study in HIV infected individuals to determine the impact of HAART and the role of specific antiviral immune responses on the establishment and maintenance of virus reservoirs, which are key for chronic virus persistence and disease progress SAN GALLICANO Ensoli Fabrizio AIDS and Related Research AIDS Studies and Epidemiology ACE Pagina 92 di 167

93 Understanding and enhancing the therapeutic effect of FTY720 (Fingolimod) in multiple sclerosis: a structural biology approach Degano Massimo Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function E MSFE MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs FATEBENEFRATELLI Bocchio Chiave Luisella Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche Tinuper Paolo CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME Bone Morphogenetic Protein pathway induces Cancer Stem Cells differentiation enhancing the chemosensitivity of breast and colorectal cancers to conventional chemotherapy Sicilia Todaro Matilde Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Identification of downstream targets of BAG3/BRAFmediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma PASCALE chiappetta gennaro Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Targeted resequencing of genomic regions by next generation sequencing technologies GASLINI Ravazzolo Roberto Genes, Genomes and Genetics Genetics of Health and Disease GHD Regulation of mitotic transitions I.E.O. Visintin Rosella Cell Biology Cellular Signaling and Regulatory Systems CSRS Characterization of interactions among tumor, stromal and immune cells for the identification of potential targets in melanoma therapy. IRCCS AOU San Martino IST (Genova) Mingari Maria Cristina Immunology Transplantation, Tolerance and Tumor Immunology TTT ROLE OF ENPP1 AND HSP70 SERUM LEVELS ON CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS CASA SOLLIEVO SOFFERENZA Rosa Di Paola Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Pagina 93 di 167

94 Splicing variants of L1CAM in human cancer cells: functional relevance in modulating NK cell mediated antitumor activity. HUMANITAS Mikulak Joanna Immunology Transplantation, Tolerance and Tumor Immunology TTT Oxidative stress in animals cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumours Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Ferrari Angelo Veterinary Animal Health ANHE Title: Developing and Evaluation of innovative methods for detecting and trace infective pathogens in foods: molecular correlation with human cases Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia LOSIO MARINA NADI Veterinary Food Safety FOSA EVALUATION OF HUMORAL AND CELLULAR REACTIVITY IN KIDNEY ALLOGRAFT PATIENTS: NEW TOOL TO TRIM THE IMMUNOSUPPRESIVE THERAPY IN ACCORDING TO THE AGE Piemonte amoroso antonio CLI Immunology Transplantation, Tolerance and Tumor Immunology TTT Bergamot Polyphenol Fraction as a treatment for metabolic syndrome and related cardiovascular complications: focus on mechanisms and bases of in vivo efficacy SAN RAFFAELE PISANA Rosano Giuseppe Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP CONTROL AND MANAGEMENT OF LOGICAL FOOD RISKS: SETUP AND APPLICATION OF INNOVATING MODELS BASED ON TECHNOLOGICAL METHODS FOR DETECTION OF VIRUS, PARASITES AND BACTERIA Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Finazzi Guido Veterinary Food Safety FOSA Adult Niemann Pick type C disease as a model of tauopathy. Implications for the pathogenesis of Alzheimer disease. CARLO BESTA Giaccone Giorgio Brain Disorders and and CNN Randomized controlled clinical trial comparing Y90 TARE (Transarterial Radioembolisation with Y90) to sorafenib in the treatment of advanced HCC complicated with portal vein thrombosis Emilia Romagna Golfieri Rita CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Pagina 94 di 167

95 EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE FATEBENEFRATELLI Balestrieri Matteo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD IDENTIFYING CORRELATIONS BETWEEN GENOTYPES AND PHENOTYPES OF DENT'S DISEASE. PARTICIPATION TO THE INTERNATIONAL DENT S DISEASE REGISTRY Veneto Anglani Franca Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES AND CLINICAL APPROACHES IN GASTRIC CARCINOMA THAT PROVIDE INFORMATIVE CLUES FOR EARLY DIAGNOSIS AND TREATMENT OF GASTRIC CANCER C.R.O. AVIANO DE RE VALLI Oncology 2 Cancer Biomarkers CBSS CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA LATIANO Anna Genes, Genomes and Genetics Genetics of Health and Disease GHD Dissecting the molecular regulatory networks in human myeloid derived suppressor cells. I. O. V. Mandruzzato Susanna Immunology Innate Immunity And Inflammation III Identification of metabolic and immunological parameters predictive for the risk of diseases or fertility problems in periparturient dairy cows Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Lacetera Nicola Veterinary Animal welfare ANWE Hypertension in children adolescents:predictors,risk factors and intra uterine growth retard Toscana Strambi Mirella CLI Healthcare Delivery and Nursing Science: Children and Families NSCF CORRELATION BETWEEN BREST ARTERIAL CALCIFICATIONS AT MAMMOGRAPHY AND CORONARY ARTERY CALCIUM SCORE IN ASYMPTOMATIC DIABETIC PATIENTS: TWO SCREENING IN ONE SAN DONATO Sardanelli Francesco CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 95 di 167

96 Functional studies of deregulated micrornas in Sezary Syndrome ISTITUTO DERMOPATICO DELL'IMMACOLATA Narducci Maria Grazia Oncology 1 Basic Cancer Molecular Pathobiology CAMP ZnO nanoparticles as selective killers of liver metastasis derived from colon cancer SAN MATTEO Pietrabissa Andrea Bioengineering Sciences and Technologies Nanotechnology NANO Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA FINOCCHIAR GAETANO CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Diagnostic impact of circulating mirna and cancer cells in poorly differentiated carcinomas of the lung and breast. Emilia Romagna Foschini Maria Pia Oncology 2 COCAINE CHEST PAIN Emilia Romagna pavarin raimondo CLI Risk, Prevention and Health Behavior Cancer Biomarkers CBSS Risk, Prevention and Intervention for Addictions RPIA Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Calabria Citraro Rita Brain Disorders and Acute Neural Injury and Epilepsy ANIE MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL Toscana Taccetti Giovanni CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Identification of mirna based Therapeutical Targets in Gliomas by Integrated Genomic Analyses. CASA SOLLIEVO SOFFERENZA PAOLA PARRELLA Oncology 1 Basic Molecular Oncogenesis MONC Pathogenesis of Multiple Sclerosis: role of Fas/FasLigand and TNFalfa/TNFR1 and TNFR2 systems in the apoptosis of T cells autoreactive to myelin NEUROLESI sofo vincenza Immunology Hypersensitivity, Autoimmune, and Immune mirna and vascular diseases: role of mir149, mir155, mir31, mir126, mir17 3p in endothelial dysfunction IRCCS AOU San Martino IST (Genova) Palombo Domenico Vascular and Hematology Vascular Cell and Molecular Biology VCMB Pagina 96 di 167

97 EFFECTS OF NUTRACEUTICAL SPIRULINA AND DOCOSAHEXAENOIC ACID ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENT AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY Istituto Superiore di Sanita' De Simone Roberta Molecular, Cellular, and Developmental Cellular and Molecular Biology of Glia CMBG BPIFB4 longevity associated variants: evaluation by in vitro and in vivo studies for their potential modulation of diseases of aging MULTIMEDICA Puca Annibale Alessa Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Development of a novel test for detection of Bacillus anthracis DNA in urine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Fasanella Antonio Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS DESIGN OF NOVEL RATIONAL THERAPEUTIC STRATEGIES FOR RET DRIVEN MEDULLARY THYROID CARCINOMA ISTITUTO TUMORI MILANO Cassinelli Giuliana Oncology 1 Basic Cancer Molecular Pathobiology CAMP An epigenetic approach to treatment of triple negative breast cancer Friuli Venezia Giulia Damante Giuseppe Oncology 1 Basic Cancer Molecular Pathobiology CAMP The role of oxidative damage to DNA and its repair in human gastrointestinal cancer Istituto Superiore di Sanita' bignami margherita Oncology 1 Basic Cancer Genetics CG A GROUP COGNITIVE/BEHAVIOURAL INTERVENTION FOR METABOLIC SYNDROME RISK REDUCTION, IN PATIENTS TREATED WITH ATYPICAL ANTIPSYCOTICS Emilia Romagna BICCHIERI LORENZA Biobehavioral and Behavioral Processes Biobehavioral and Behavioral Processes Small Business Activities SBBB UPPER LIMB IMPAIRMENT IN CHARCOT MARIE TOOTH PATIENTS: MOTOR STRATEGIES, IMPACT ON QUALITY OF LIFE AND CORTICAL FUNCTIONAL REORGANIZATION DON GNOCCHI PADUA LUCA CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Opportunistic virus infections in transplant recipients and patients with chronic inflammatory diseases treated with biological immunosuppressive drugs SAN MATTEO Baldanti Fausto Immunology Immunity and Host Defense IHD Pagina 97 di 167

98 Mobile genetic elements: new approaches to molecular epidemiology of antimicrobial resistance genes in Gramnegative clinical isolates Abruzzo Perilli Mariagrazia Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Genetic and epigenetic mechanisms in addiction: An opportunity for development of new pharmacotherapeutic strategies for alcoholism. FATEBENEFRATELLI Addolorato Giovanni Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS Colorectal cancer: Vitamin D, VDR and beta Catenin expression study: from biological pathways to clinical prevention. I.E.O. Bonanni Bernardo CLI Oncology 2 Cancer Biomarkers CBSS Treatment of Kaposi s Sarcoma by Electrochemotherapy: and Virological evaluation SAN GALLICANO bonadies antonio CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Definition of the prognostic and biological roles of tissueassociated and soluble biomarkers in epithelial ovary cancer exploiting well characterized retrospective and prospective clinical series of samples ISTITUTO TUMORI MILANO Canevari Silvana Oncology 2 Cancer Biomarkers CBSS Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cell based immunotherapy in patients with refractory disease SAN MATTEO Montagna Daniela CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment of the neurocognitive and clinical outcomes of premature newborns Scifo Paola VIttoria CLI Brain Disorders and Developmental Brain Disorders DBD Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment FATEBENEFRATELLI Gennarelli Massimo Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Pagina 98 di 167

99 Continuity of CAre for severe chronic REspiratory patients (CARE) Puglia Sabato Eugenio Healthcare Delivery and Health Services Organization and Delivery HSOD Physiopathological mechanisms of freezing of gait in Parkinson disease and development of rehabilitative therapeutic strategies S.CAMILLO pilleri manuela CLI Brain Disorders and and CNN ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia Romagna Arcangeletti Maria Cristina Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Biomaterial functionalization to improve biofunctionality and osteointegration of medical devices for healthy and osteopenic bone. RIZZOLI Giavaresi Gianluca Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia Tondini Carlo Alberto CLI Oncology 1 Basic Cancer Genetics CG Growth and oncolytic properties of Influenza A viruses in human pancreatic tumour cells and animal models Istituto Zooprofilattico Sperimentale delle Venezie Cattoli Giovanni Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB POSSIBLE ROLE OF 18F FDG PET/CT IN DEFINING THE APPROPRIATE USE OF PRRT IN PATIENTS WITH METASTATIC GEP NETs WITH EVIDENCE OF TUMOUR PROGRESSION FOLLOWING TREATMENT WITH SOMATOSTATIN ANALOGUES. ISTITUTO TUMORI MILANO Bombardieri Emilio CLI Oncology 2 Radiation Therapeutics and Biology RTB TELE PHYSICO TELEMEDICINE FOR PHYSICAL HEALTH PROMOTION IN TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre randomised controlled trial. FATEBENEFRATELLI Burti Lorenzo CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM1 Pagina 99 di 167

100 HIV 1 Nef protein affects opportunistic infections in human macrophages Immunomodulatory effects of umbilical cord Wharton jelly derived human adult mesenchymal stem cells (hucms) on circulating Tc subsets of patients with systemic autoimmune disorders such as: 1) Type 1 diabetes mellitus (T1DM); 2) Connective tissue diseases Istituto Superiore di Sanita' Olivetta Eleonora AIDS and Related Research AIDS Immunology and Pathogenesis AIP Umbria Basta Giuseppe Pietro Immunology Transplantation, Tolerance and Tumor Immunology TTT Development and evaluation of a reverse transcriptase Real Time PCR assay for the study of the presence of viable Toxoplasma gondii in vegetable and meat Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta DECASTELLI LUCIA Veterinary Food Safety FOSA Validation of a prognostic multigene classifier for larynx carcinoma, application to fine needle biopsies and functional analyses of classifier genes IRCCS AOU San Martino IST (Genova) Mora Renzo CLI Oncology 2 Cancer Biomarkers CBSS New radiotherapic technologies(t): role of hypofractionated(h) Intensity Modulated Image Guided Radiotherapy in Locally Advanced Non Small Cell Lung cancer (Stage IIIA IIIB) Emilia Romagna Bertoni Filippo CLI Oncology 2 Radiation Therapeutics and Biology RTB Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto DALLE CARB LUCA GIUSEPP Genes, Genomes and Genetics Molecular Genetics MGA Next Generation Targeted resequencing Panels as a tool for multi gene testing in the diagnosis of Parkinson Disorder SAN RAFFAELE PISANA Moles Anna Genes, Genomes and Genetics Genetics of Health and Disease GHD An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study ARCISPEDALE Argenziano Giuseppe CLI Healthcare Delivery and Health Services Organization and Delivery HSOD MARKERS OF ENDOTHELIAL PROLIFERATION IN BREAST AND COLORECTAL CANCERS: A NEW PROSPECTIVE FOR TARGET THERAPY. Sicilia Di Vita Maria Domenica CLI Oncology 2 Cancer Biomarkers CBSS Pagina 100 di 167

101 Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia BEMBI BRUNO Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG PTPRJ and EGFR as targets for innovative molecular therapies of lung cancer Calabria Trapasso Francesco Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Policystic ovary syndrome and nitric oxide. Effects of the treatment with N acetylcysteine Piemonte Martina Valentino CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER EXOME RESEQUENCING IN UNEXPLAINED RARE BLEEDING DISORDERS MAGGIORE Peyvandi Flora Genes, Genomes and Genetics Genetics of Health and Disease GHD New perspectives in colorectal cancer for early diagnosis and therapy ONCOLOGICO DI BARI MANGIA ANNITA Oncology 1 Basic Tumor Cell Biology TCB How to improve and rationalize targeted head and neck squamous cell carcinoma treatments ISTITUTO TUMORI MILANO Perrone Federica Oncology 2 Cancer Biomarkers CBSS Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Toscana Rostagno Carlo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Unraveling the fingerprint of a new subset of human tolerogenic dendritic cells Gregori Silvia Immunology Cellular and Molecular Immunology A CMIA Optimization of alloreactive natural killer (NK) cell and invariant NKT (inkt) cell mediated anti leukemia effect in children with hematological malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel OSPEDALE BAMBINO GESU' Locatelli Franco CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Pagina 101 di 167

102 Management of couples with asymptomatic urogenital infections and ART failure Toscana Oggioni Marco Rinaldo CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Istituto Superiore di Sanita' Margutti Paola Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN TIPS FOR DECOMPENSATED CIRRHOSIS: A RANDOMIZED CLINICAL TRIAL Sicilia Luca Angelo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. SDN Sacchetti Lucia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Affective symptoms dimensions and treatment outcome in unipolar and bipolar depression. Sicilia Zoccali Rocco Antonio CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Longone Patrizia Brain Disorders and Cell Death in CDIN Identification in patients with gastric cancer of molecular events predictive of peritoneal carcinomatosis and of the response to heated intraperitoneal chemotherapy. ORSENIGO ELENA CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Mechanisms of interplay between Mycobacterium avium subspecies paratuberculosis and intestinal cells in Crohn s disease Istituto Zooprofilattico Sperimentale delle Venezie castagliuolo ignazio Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology GMPB Revealing brain mechanisms of Chronic Subjective Dizziness SANTA LUCIA Indovina Iole Integrative, Functional, and Cognitive Auditory System AUD Pagina 102 di 167

103 Identification of biomarkers to be predictive of response to anti CTLA4 treatment in the peripheral blood and tissues of melanoma patients. PASCALE Ascierto Paolo Antonio Immunology Transplantation, Tolerance and Tumor Immunology TTT Individual and social effects of a sensitisation campaign on headache Lazio Di Piero Vittorio CLI Healthcare Delivery and Community Level Health Promotion CLHP Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. PASCALE Carriero Maria Vincenza Oncology 1 Basic Tumor Progression and Metastasis TPM Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cells and gamma/delta T lymphocytes and regulation of their cross talk. Istituto Superiore di Sanita' Gauzzi Maria Cristina Immunology Hypersensitivity, Autoimmune, and Immune Guided bone regeneration with innovative degradable scaffolds RIZZOLI Nicoli Aldini Nicolò Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Does adolescents perception of parental and peer drinking habits and lifestyle affect their approach to alcohol consumption? Molise de Gaetano Giovanni CLI Healthcare Delivery and Health and Health Related Behavior of Individuals and Populations Fellowship F Interim FDG PET/CT in the assessment of early response to concurrent chemo radiotherapy in patients with nonsmall cell lung cancer stage IIIA IIIB ARCISPEDALE Versari Annibale CLI Oncology 2 Radiation Therapeutics and Biology RTB Characterization of extrapyramidal features in mitochondrial disorders S.CAMILLO Pegoraro Elena CLI Brain Disorders and and CNN Whole Exome sequencing a novel modality for diagnostics and disease gene discovery in Cardiomyopathies MULTIMEDICA Roncarati Roberta CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 103 di 167

104 Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Cappellini Germana Integrative, Functional, and Cognitive Sensorimotor Integration SMI Electronic Medical Record for PDD: A powerful tool for health care, clinical governance and epidemiological studies Istituto Superiore di Sanita' Chiarotti Flavia Healthcare Delivery and Health Services Organization and Delivery HSOD Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? Istituto Zooprofilattico Sperimentale delle Venezie Biancotto Giancarlo Veterinary Food Safety FOSA Wnt related proteins in the peripheral blood as potential predictors of response to lithium treatment in bipolar patients. NEUROMED Girardi Paolo Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA EARLY NEURAL CONNECTIVITY DEVELOPMENT: A PRENATAL FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Veneto Manara Renzo Biology of Development and Aging Development 1 DEV INVESTIGATING PROGRESSION FROM PRENEOPLASTIC TO NEOPLASTIC DISEASE IN ESOPHAGEAL AND PANCREATIC CANCER BY MEANS OF AN INTEGRATIVE GENOMICS NEXT GENERATION SEQUENCING BASED APPROACH. Testoni Pier Alberto CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Cioni Giovanni CLI Brain Disorders and Developmental Brain Disorders DBD Tailoring micro nanocarriers structural and surface properties to finely modulate the activation or regulation of immune responses: the allergy immunotherapy proof of concept Istituto Superiore di Sanita' DI FELICE GABRIELLA Immunology Hypersensitivity, Autoimmune, and Immune Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A preclinical study. Istituto Superiore di Sanita' Giammarioli Anna Maria Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 104 di 167

105 Title: Study on target therapies Impact in breast cancer patients on a wide area ofnorthern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma,Piacenza Tumour Registry ARCISPEDALE panebianco michele CLI Oncology 2 Oncology CONC Study of basic and clinical aspects of mitotane treatment in patients with adrenocortical carcinoma. Piemonte Terzolo Massimo Oncology 2 Oncology CONC Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA Pastore Saveria Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Functional significance of manipulating endogenous neurogenesis for nigrostriatal dopaminergic neuroprotection/neurorepair in murine models of Parkinson s disease: focus on neuroinflammation OASI MARIA S.S. Marchetti Bianca Maria Brain Disorders and and CNN Development and progression of breast cancer: when EMT meets stemness C.R.O. AVIANO Santarosa Manuela Oncology 1 Basic Tumor Progression and Metastasis TPM BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by The Program of Molecular & Endocrinology and Women s Endocrine Health. Sicilia Benvenga Salvatore CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F High throughput sequencing to reveal the undesired microbiota in raw cheeses Istituto Zooprofilattico Sperimentale del Mezzogiorno ALFANO FLORA Veterinary Food Safety FOSA Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis. Emilia Romagna Medici Maria Cristina Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship F13 Pagina 105 di 167

106 Development of bispecific antibodies for therapeutic approaches against HIV infection. Istituto Superiore di Sanita' Titti Fausto AIDS and Related Research AIDS Discovery and Development of Therapeutics ADDT The BRCAness profile: from the molecular basis to the clinical relevance Toscana Caligo Maria Adelaide Oncology 1 Basic Cancer Genetics CG To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Massimo Carella Genes, Genomes and Genetics Genetics of Health and Disease GHD Imaging and radioimmunotherapy of pancreatic cancer I. O. V. Rosato Antonio Surgical Sciences, Biomedical Imaging, and Bioengineering Molecular Imaging and Probe Development CMIP Detection of Mycobaceterium avium subsp. paratuberculosis in human Crohn s disease and in ruminants and possible role of contaminated food Istituto Zooprofilattico Sperimentale del Mezzogiorno Castiglione Fabiana CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO Mauro Alessandro CLI Emerging Technologies and Training in s Neurophysiology, Devices, Auditory Devices and Neuroprosthesis Small Business SBNE LOW INVASIVE MARKERS DEVELOPMENT IN COLLAGEN 6 MYOPATHIES AND DUCHENNE MUSCULAR DYSTROPHY FOR DISEASE STAGING AND RESPONSE TO TREATMENT RIZZOLI Merlini Luciano CLI Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP WHOLE EXOME SEQUENCING OF ADENOMATOUS POLYPOSIS PATIENTS FOR A GENETIC DIAGNOSIS AND CLINICAL APPLICATIONS C.R.O. AVIANO Viel Alessandra Oncology 1 Basic Cancer Genetics CG Mice models of osteosarcoma and hemangiosarcoma development. Early molecular and immunological mechanisms involved in tumor onset and malignancy as targets of innovative therapies. RIZZOLI Landuzzi Lorena Oncology 1 Basic Tumor Cell Biology TCB Pagina 106 di 167

107 Exploring the role of drusen in the retinas as possible markers for the Alzheimer s disease pathology: a multidisciplinary approach. Istituto Superiore di Sanita' Crestini Alessio Brain Disorders and and CNN Assessing antibiotic resistance in nonpathogenic foodrelated bacteria: the impact on human gut microbiota Istituto Zooprofilattico Sperimentale delle Venezie Ricci Antonia Veterinary Food Safety FOSA The contribution of ICT to patient safety in surgical process Emilia Romagna RODELLA STEFANIA CLI Healthcare Delivery and Biomedical Computing and Health Informatics BCHI Development of a multiplex standard polymerase chain reaction assay for identification of infectious agents from aborted ruminants clinical samples Istituto Zooprofilattico Sperimentale del Mezzogiorno AURIEMMA CLEMENTINA Veterinary Animal Health ANHE Circulating Tumour Cells (CTC) and Cancer Stem Cells from human prostate: new device and tools for markers detection,cell isolation and their ex vivo expansion as three dimensional structures Lazio Gentile Vincenzo Digestive, Kidney and Urological Systems Urologic and Kidney Development and Genitourinary Diseases UKGD Effect of lower limb end effector robot assisted therapy with body weight support vs treadmill gait training in Parkinson Patients. SAN RAFFAELE PISANA Franceschini Marco CLI Brain Disorders and and CNN BiS trial: randomized controlled trial on biologic vs synthetic mesh for the treatment of large defect congenital diaphragmatic hernia. OSPEDALE BAMBINO GESU' Bagolan Pietro CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Prospective multicenter study on the efficacy of a new, taylored on risk class, antibiotic prophylaxis protocol in preventing neurosurgical Surgical Site Infection (SSIs). Lombardia Valentini Laura Grazia CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS High field MR evaluation in low level consciousness patients NEUROLESI De Stefano Nicola CLI Brain Disorders and and CNN Pagina 107 di 167

108 Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular indicators for clinical/disease staging and vaccine efficacy Istituto Zooprofilattico Sperimentale della Sicilia Loria Guido Ruggero Veterinary Animal Health ANHE Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI Meliconi Riccardo CLI Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS NANOTECHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER REGINA ELENA Leonetti Carlo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Prognostic role of arterial stiffness and vascular calcifications on peripheral arterial occlusive disease in chronic kidney disease. A multi center, observational, prospective, non invasive study. AUXOLOGICO Salvi Paolo CLI Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES: A MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS MONDINO marchioni enrico CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Person/Patient and Family centred care PCC & FCCUnderstanding health care experiences and perceptions of parents of hospitalized premature infants, children with a chronic condition and their parents and health professionals in South Tyrol and other reg Provincia autonoma Bolzano Tappeiner Waltraud CLI Healthcare Delivery and Nursing Science: Children and Families NSCF Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. SAN RAFFAELE PISANA Berghella Libera Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Predictive value of FDG PET/CT Metabolic Tumour Volume in patients treated with neoadjuvant chemoradiation therapy for locally advanced rectal cancer Liguria ciarmiello andrea CLI Oncology 2 Cancer Biomarkers CBSS Normal and pathological development of locomotion in the first year of life SANTA LUCIA Ivanenko Yury Brain Disorders and Developmental Brain Disorders DBD Pagina 108 di 167

109 Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. Lombardia BENDOTTI Caterina Brain Disorders and Cell Death in CDIN Application of new PET tracers for early imaging of radiation induced lung fibrosis in a mouse model Toscana Biti Giampaolo Oncology 2 Radiation Therapeutics and Biology RTB HOSPITAL PROCEDURES FOR ACUTE HEART FAILURE AND INTEGRATED COUNTRY/HOSPITAL CARE Sicilia FERRARA GAETANO CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Frameless localisation technique for brain stereotactic radiotherapy Toscana pallotta stefania CLI Oncology 2 Radiation Therapeutics and Biology RTB Fertility preservation in women affected by endometriosis through oocyte vitrification Toscana PETRAGLIA FELICE CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER Genotoxicity, biochemical and tissutal responses in aquatic organisms exposed to chlorpyrifos and deltamethrin, assessing their risk for animal and human health Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Elia Antonia Concett Veterinary Food Safety FOSA Role of CREB protein family members in human lymphoid malignancies Abruzzo Di Pietro Roberta Cell Biology Cellular Signaling and Regulatory Systems CSRS Telemedicine Services for UTAP Veneto Mariotto Aldo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Fast tracking of proximal femur fractures: evaluation of the efficacy by means of quantitative neuromotor conditions assessment at mid time follow up. RIZZOLI Toni Aldo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 109 di 167

110 Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms Alessio Massimo Brain Disorders and Cell Death in CDIN Soluble biomarkers predicting coronary bypass graft patency MONZINO ALAMANNI FRANCESCO R CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Evaluation of neuroendocrine derangements after severe acquired brain injuries: influence on clinical progression and functional recovery during rehabilitation Emilia Romagna Bondanelli Marta CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Identification of molecular biomarkers to improve the preoperative diagnosis of follicular type thyroid cancer in the TIR3 cytologic stage as determined by classic FNA cytology Emilia Romagna pastore antonio CLI Oncology 2 Cancer Biomarkers CBSS Bioethical issues in the use of the new criteria for Prodromal Alzheimer disease: disclosure of the diagnosis, clinical trials, social impact. FATEBENEFRATELLI Porteri Corinna Brain Disorders and and CNN PROTIC TREATMENT TO PREVENT ALLERGEN SENSITIZATION: A PRECLINICAL STUDY IN PREGNANT AND NEWBORN MICE Istituto Superiore di Sanita' Barletta Bianca Immunology Cellular and Molecular Immunology A CMIA Allergic contact dermatitis to nickel and related alloys SAN GALLICANO Cristaudo Antonio Cardiovascular and Physiology and Pathobiology of Musculoskeletal, Oral, and Skin Systems PPMO Allergens, chemical and biological contaminants in nursery and primary schools: a proposal of a multimethod approach for the assessment of the main risk pollutants Istituto Superiore di Sanita' Pini Carlo Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA Pagina 110 di 167

111 Diagnosis and pathogenesis of Opisthorchis felineus, an emerging foodborne parasite in Italy Istituto Superiore di Sanita' Gomez Morale Maria Angeles Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship F Identification of new heart related mirnas as tools for diagnosis and terapy of heart malformations and diseases Emilia Romagna Pace Napoleon Carlo Cardiovascular and Cardiovascular Differentiation and Development CDD Glia immune crosstalk in multiple sclerosis Farina Cinthia Molecular, Cellular, and Developmental Cellular and Molecular Biology of Glia CMBG Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO Sandrini Giorgio Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC The pathophysiological substrates of myoclonic syndromes: implementation of innovative multimodal functional approach and treatments CARLO BESTA Franceschetti Silvana Brain Disorders and Acute Neural Injury and Epilepsy ANIE Functional and effective connectivity evaluation in drugresistant epileptic patients candidates to surgery.a new tool for identification of the seizure onset zone and prediction of memory and cognitive outcome. Toscana ROSSI ALESSANDRO CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Predictive models of genito urinary and sexual dysfunction after high dose radiotherapy for prostate cancer ISTITUTO TUMORI MILANO Rancati Tiziana CLI Oncology 2 Radiation Therapeutics and Biology RTB Development and validation of a set of indicators based on administrative data to monitor long term care for disabled elderly Agenzia per i Servizi Sanitari Regionali damiani gianfranco CLI Healthcare Delivery and Health Services Organization and Delivery HSOD New frontiers in breast imaging: contrast enhanced digital mammography. performance of contrastenhanced spectral mammography (CESM SenoBright) in pre surgical evaluation of extent of malignancy in a population of women with breast cancer. I.E.O. Cassano Enrico CLI Oncology 2 Cancer Biomarkers CBSS Pagina 111 di 167

112 ROLE OF HOST AND VIRAL FACTORS ON THE EXPERIMENTAL INFECTIONS OF CYNOMOLGUS MACAQUES WITH SIMIAN OR SIMIAN HUMAN IMMUNODEFICIENCY VIRUS. Istituto Superiore di Sanita' Borsetti Alessandra AIDS and Related Research AIDS Immunology and Pathogenesis AIP The use of Nanoparticles in food technology: release assessment and development of analytical methods through selected case studies Istituto Zooprofilattico Sperimentale delle Venezie Cibin Veronica Bioengineering Sciences and Technologies Nanotechnology NANO Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE PISANA Palamara Anna Teresa Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR TREATMENT OF CHRONIC END STAGE LIVER DISEASE (ESLD) Emilia Romagna Andreone Pietro CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Aberrant choline metabolism in ovarian cancer as a source of multilevel data in prognosis and/or therapeutic guidance. ISTITUTO TUMORI MILANO Mezzanzanica Delia Oncology 2 Cancer Biomarkers CBSS Development and exploitation of a platform able to produce antibody based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology ISTITUTO TUMORI MILANO Figini Mariangela Oncology 2 Cancer Immunopathology and Immunotherapy CII The reactivity to 35% CO2 challenge as predictor of pharmacological treatment outcome and relapse in Panic Disorder. Lombardia Perna Giampaolo Robe CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Isolation and characterization of mesenchymal stem cells: therapeutic implications for cardiac disease Emilia Romagna GHERLI TIZIANO Cardiovascular and Cardiovascular Differentiation and Development CDD Quantitative evaluation of the function of the elbow operated through inertial devices RIZZOLI Benedetti Maria Grazia Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Pagina 112 di 167

113 Effects of high intensity robot assisted training in hand function recovery and ADL independence after stroke: a multicentre randomized controlled single blind trial SAN RAFFAELE PISANA Smania Nicola CLI Brain Disorders and Developmental Brain Disorders DBD value of decompressive craniectomy associated to haematoma evacuation in the first 72 hours after traumatic events: a multicenter randomized controlled trial Emilia Romagna servadei franco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Sharing of medical resources for the diagnosis and treatment of status epilepticus by a computer assisted telemedicine system Minicucci Fabio CLI Emerging Technologies and Training in s Neurophysiology, Devices, Auditory Devices and Neuroprosthesis Small Business SBNE ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES SDN IZZO PAOLA CLI Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Brain complexity and complexity matching for enhancing the positive effects of environmental enrichment on psychopathology Istituto Superiore di Sanita' macellari velio CLI Integrative, Functional, and Cognitive Cognitive COG PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Ferraro Donatella Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Inflammation, angiogenesis and micrornas in malignant mesothelioma. Toscana Fontanini Gabriella Oncology 1 Basic Tumor Microenvironment TME Primary prevention of Neural Tube Defects (NTD) by Inositol: the ASBI case control study Liguria Capra Valeria CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Pagina 113 di 167

114 Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients with Medullary Thyroid Cancer PASCALE pezzullo luciano CLI Oncology 2 Oncology CONC Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' Tozzi Alberto Eugenio CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Evaluation of Neuroprotection with NGF Mimetic Compounds Using Molecular Microimaging of Apoptotic Post ischemic Neuronal Death Toscana Pellegrini Gia Domenico Edoar Brain Disorders and Brain Injury and Neurovascular Pathologies BINP TRANSLATING MELANOMA EPIGENETICS IN THE CLINICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Toscana Maio Michele Oncology 2 Cancer Immunopathology and Immunotherapy CII Development of a Preclinical Model of Peritoneal Carcinomatosis with Cells from patients with Human Gastric Cancer socci carlo Oncology 1 Basic Tumor Progression and Metastasis TPM DEVELOPMENT OF A METHOD FOR NON INVASIVE ROUTINE PRENATAL DIAGNOSIS OF MONOGENIC DISORDERS USING CELL FREE DNA IN MATERNAL PLASMA Veneto CLEMENTI MAURIZIO Genes, Genomes and Genetics Genetics of Health and Disease GHD Immunogenic cell death as predictive and real time marker of response to EGFR targeted therapy in CRC patients I.E.O. Penna Giuseppe Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Role of stromal cells in lymphoma mediated immunosuppression: a novel target for the treatment. IRCCS AOU San Martino IST (Genova) Poggi Alessandro Oncology 1 Basic Tumor Microenvironment TME Role of the mitogen activated protein kinase ERK5 in chronic liver injury and hepatocellular carcinoma Toscana Marra Fabio Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Pagina 114 di 167

115 Improving balance through gravity cues embedded in free falling target SANTA LUCIA Maffei Vincenzo Biobehavioral and Behavioral Processes Motor Function, Speech and Rehabilitation MFSR Evaluation of the role of Copy Number Variations in the pathogenesis of inherited neurological and neuromuscular disorders through the development and validation of a rapid and efficient laboratory assay IRCCS AOU San Martino IST (Genova) Mandich Paola Genes, Genomes and Genetics Genetics of Health and Disease GHD Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms AUXOLOGICO Larizza Lidia Genes, Genomes and Genetics Genetics of Health and Disease GHD MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS MAGGIORE Cappellini Maria Domenica Genes, Genomes and Genetics Genetics of Health and Disease GHD "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. MAGGIORE Colombo Massimo Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP NEURONAL POTASSIUM CHANNEL KV3.4 AS A NON TRADITIONAL MOLECULAR TARGET FOR THE DEVELOPMENT OF DRUGS PREVENTING NEURONAL CELL DEATH IN ALZHEIMER DISEASE SAN RAFFAELE PISANA Pannaccione Anna Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Prognostic role of serum pro PSA, circulating tumor cells and serum testosterone levels in prostate cancer patients with biochemical progression undergoing androgen deprivation therapy Piemonte Berruti Alfredo CLI Oncology 2 Oncology CONC Telemedicine in cardiology:training of a virtual team SAN RAFFAELE PISANA maurizio volterrani CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Cognitive stimulation versus music therapy in patients with cognitive impairment secondary to multiple sclerosis or brain tumor CARLO BESTA Giovagnoli Anna Rita CLI Brain Disorders and and CNN Pagina 115 di 167

116 The effect of pulmonary rehabilitation on the reduction of acute exacerbations in patients with COPD. The impact of inflammatory phenotype DON GNOCCHI Scano Giorgio Luigi CLI Cardiovascular and Small Business Activities ZRRS WAC Project (Web Based Asthma Control) evaluation of the utility of a web based electronic health diary to improve control of moderate severe asthma Toscana Corbetta Lorenzo CLI Cardiovascular and Small Business Activities ZRRS Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications Emilia Romagna Pelà Giovanna Maria Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR A pharmacogenomic approach for Interferons treatment in multiple sclerosis MARTINELLI FILIPPO CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Role of T cell subpopulations in the pathogenesis of Multiple Sclerosis NEUROLESI Salmeri Francesca Maria Immunology Hypersensitivity, Autoimmune, and Immune governance and occupational well being: a new organizational approach to healthcare performance Emilia Romagna Fabbri Tommaso CLI Healthcare Delivery and Health Services Organization and Delivery HSOD DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER2+ cancer patients Piemonte GIOVARELLI MIRELLA Oncology 2 Cancer Immunopathology and Immunotherapy CII Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB Weisz Alessandro Oncology 1 Basic Cancer Molecular Pathobiology CAMP The role of Integrin alpha5/beta1 as a potential therapeutic target in bone metastasis: a translational study I. O. V. ZOVATO STEFANIA Oncology 2 Developmental Therapeutics DT Pagina 116 di 167

117 The key role of serotonin in the pathophysiology of phenylketonuria: from bench to bedside OASI MARIA S.S. Romano Valentino Brain Disorders and Developmental Brain Disorders DBD Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Brocchi Emiliana Veterinary Animal Health ANHE Cardiotoxicity of anticancer treatments. Biomarkers and diagnostic tools for evaluation of cardiological risk of oncological patients MULTIMEDICA Albini Adriana CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS PLERIXAFOR ADMINISTRATION AND MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS TO PROMOTE NEO VASCULARIZATION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA Marrocco Trisc Massimiliano M. CLI Cardiovascular and Cardiovascular Differentiation and Development CDD Circulating microrna as potential biomarkers of prediabetic and diabetic complications Veneto Semplicini Andrea Cardiovascular and and Integrative Cardiovascular Sciences CICS Fibrin resistance to lysis in pulmonary hypertension Toscana Miniati Massimo Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR A new approach to cancer early diagnosis based on the identification of breast cancer related metabolites in human breath ISTITUTO TUMORI MILANO Orlandi Rosaria Oncology 2 Cancer Biomarkers CBSS Involvement of mutant p53 gain of function in tumor microenvironment REGINA ELENA Bossi Gianluca Oncology 1 Basic Tumor Microenvironment TME A MULTIMODALITY APPROACH TO PREVENT THE NEUROLOGICAL DYSFUNCTION IN CARDIAC SURGERY Veneto Polesel Elvio CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Pagina 117 di 167

118 RELATIOSHIPS BETWEEN VASOACTIVE MEDIATORS AND HEMODYNAMIC ALTERATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS. Toscana CERASE Alfonso CLI Brain Disorders and and CNN IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED CLINICAL PARAMETERS MULTIMEDICA Noonan Douglas CLI Oncology 2 Cancer Biomarkers CBSS Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. BURLO GAROFALO Not Tarcisio CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Conservative and surgical care pathway in patients with neuromuscular scoliosis RIZZOLI GREGGI TIZIANA CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Ring annuloplasty versus Suture repair for the treatment of Not Severe Tricuspid Regurgitation in patients undergoing surgery for Mitral Valve disease: a Prospective, Randomized Study. Alfieri Ottavio CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT The burden of arterial and venous thromboembolism in the Italian active population: a twenty years long prospective VITA (VIcenza Thrombophilia and Atherosclerosis) COhort STudy (VITA COST) Veneto Tosetto Alberto CLI Vascular and Hematology Hemostasis and Thrombosis HT Innovative tools to predict the response to chemotherapy in cancer patients Corti Angelo Oncology 1 Basic Tumor Microenvironment TME Novel approaches to the functional characterization of unclassified variants in BRCA genes. ISTITUTO TUMORI MILANO Radice Paolo Oncology 1 Basic Cancer Genetics CG Pagina 118 di 167

119 Protective role of high density of tumor associated macrophages in stage III colorectal cancer HUMANITAS Malesci Alberto Oncology 2 Cancer Immunopathology and Immunotherapy CII Targeting altered proton dynamics of sarcomas as an effective therapeutic tool RIZZOLI Baldini Nicola Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health Istituto Superiore di Sanita' Tabocchini Maria Antonella Oncology 2 Radiation Therapeutics and Biology RTB Application of molecular techniques to identify zoonosis agents transmitted by arthropods. Istituto Zooprofilattico Sperimentale del Mezzogiorno manna laura Veterinary Animal Health ANHE Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto Da Dalt Liviana CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Prognostic marker of cytomegalovirus infection and transmission in pregnancy. Emilia Romagna Landini Maria Paola CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Detection and management of Thyroid nodules: assessment of a screening program carried out by General Practitioners ARCISPEDALE Valcavi Roberto CLI Healthcare Delivery and Community Level Health Promotion CLHP TAT AND ENV BIND TO FORM A NOVEL HIV ENTRY COMPLEX THAT TARGETS CELLS AT THE PORTAL OF ENTRY AND HIV RESERVOIRS: IMPLICATIONS FOR THE DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC INTERVENTIONS AGAINST HIV/AIDS Istituto Superiore di Sanita' CAFARO AURELIO AIDS and Related Research AIDS Immunology and Pathogenesis AIP Pagina 119 di 167

120 Home based palliative care for people with severe multiple sclerosis: Developmental and pilot phases of the Palliative Network for Severely Affected Adults with MS in Italy (PeNSAMI) study CARLO BESTA Solari Alessandra CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Genotypes of Toxoplasma gondii their phylogeny, pathogenicity and transmission among wildlife, livestock and humans. Eating ectoparasites is an additional factor of risk for infection? Istituto Zooprofilattico Sperimentale del Lazio e della Toscana calderini pietro Veterinary Animal Health ANHE Pathogenetic role and potential clinical exploitation of the CCL2/CCR2 axis in the regulation of immune responses in ALS HUMANITAS Locati Massimo Immunology Cellular and Molecular Immunology A CMIA Posttraumatic stress disorder in parents of children with surgically correctable anomalies requiring surgery at birth OSPEDALE BAMBINO GESU' Zaccara Antonio Maria CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' Castrucci Maria Rita Immunology Vaccines Against Microbial Diseases VMD GABAA receptor and chloride transporter physiopathological role in ALS SANTA LUCIA ZONA CRISTINA Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND A novel in vivo system for functional reconstitution of bone and a functional bone marrow microenvironment/hematopoietic stem cell niche: a lead into scaffold free, cell only bone regeneration strategies, and into direct modeling of leukemic and cancer st Lazio Bianco Paolo Vascular and Hematology Hematopoiesis HP Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. Zangrillo Alberto CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 120 di 167

121 Motor underpinnings to screen autism (MUSA). Prospective study on movement perception and performance in younger siblings of children with Autism Spectrum Disorders. Searching for clinical predictors and neural correlates of early autism. STELLA MARIS Muratori Filippo CLI Brain Disorders and Developmental Brain Disorders DBD ROLE OF HUMAN PAPILLOMAVIRUS IN THE DEVELOPMENT OF PENILE CANCER IN PATIENTS WITH LICHEN SCLEROSUS: CLINICAL, VIDEODERMATOSCOPIC, HISTOPATHOLOGIC AND MOLECULAR STUDY Sicilia Micali Giuseppe CLI Oncology 1 Basic Cancer Etiology CE Electroclinical and genetic characterization of Epilepsy in a population of patients with ring 20 chromosome syndrome. EEG fmri study and comparison with a group of patients with frontal lobe epilepsies (genetic and structural etiologies) Lombardia Canevini Maria Paola CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Vitamin D supplements in geriatric major depression Emilia Romagna Amore Mario CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Sicilia Firenze Alberto Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study. ARCISPEDALE Pioli Giulio CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA Colognesi Cap Maurizio Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Pagina 121 di 167

122 Tubercolosis in neonates and infants: novel approach to the diagnosis and to the management. OSPEDALE BAMBINO GESU' VILLANI ALBERTO CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS CORRELATIONS OF THE CLINICO NEUROPHYSIOLOGICAL FEATURES WITH THE HISTOPATHOLOGICAL FINDINGS AND microrna EXPRESSION IN DRUG RESISTANT TEMPORAL LOBE EPILEPSY Istituto Scienze Neurologiche Rubboli Guido Brain Disorders and Acute Neural Injury and Epilepsy ANIE Role of acetylcholinesterase R in the treatment of Myastenia Gravis. SAN RAFFAELE PISANA Granone Pierluigi CLI Oncology 2 Developmental Therapeutics DT Optimization of the number of fractions in hypofractionated external beam radiation therapy: suggestions from fitting a reoxygenation including TCP model to in vivo and to clinical data. Veneto Ruggieri Ruggero Oncology 2 Radiation Therapeutics and Biology RTB PGD in genetic alteration and repeated failures in IVF patients Toscana La Mantia Rosa CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction CMIR Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' Tartaglia Marco Genes, Genomes and Genetics Genetics of Health and Disease GHD Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO Massarut Samuele CLI Oncology 2 Oncology CONC Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Scacchia Massimo Veterinary Animal Health ANHE Virus associated tumors: identification of novel diagnostic, prognostic and treatment strategies SAN MATTEO Pedrazzoli Paolo CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Pagina 122 di 167

123 The challenge of risk stratification in cardiac surgery: the ACEF PLUS to catch extreme conditions SAN DONATO Castelvecchio Serenella CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Identification of novel targets in thyroid carcinogenesis by sirna based loss of function screening ISTITUTO TUMORI MILANO Miranda Claudia Oncology 1 Basic Tumor Cell Biology TCB PROBING THE ROLE OF ION CHANNELS IN NEUROPATHIC PAIN CARLO BESTA Lauria Giuseppe Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC A randomized multicenter study to compare the efficacy of additional tumor debulking surgery versus chemotherapy (CT) alone for recurrent platinum(p) sensitive ovarian cancer (OC) PASCALE Greggi Stefano CLI Oncology 2 Oncology CONC Papillomavirus (HPV) genital infection in men: genotypes prevalence, presence of viral transcripts and association with genital clinical signs and sperm function Sicilia PERINO ANTONINO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Sgk1: a novel regulator of genomic stability in human cancer Calabria perrotti nicola Oncology 1 Basic Cancer Genetics CG A multicentric case control study on Gastrointestinal (GI) microbiota, diet and immune system activation: effects of microbial modulation in healthy subjects and patients affected by Irritable Bowel Sydrome and Inflammatory Bowel Disease. Istituto Superiore di Sanita' ciccozzi massimo Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP Emerging technologies for genome manipulation, detection and characterization of West Nile virus strains Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Lelli Rossella Veterinary Animal Health ANHE Pagina 123 di 167

124 Sacral neuromodulation as treatment of urge incontinence in frail elderly female patients: a study of feasibility, safety and cost effectiveness analysis. Lazio Zullo Marzio Angelo CLI Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities SERU Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA Ferraro Elisabetta Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP ANTIOXIDANT PROTECTION IN HIV RELATED NEURODEGENERATIVE DISORDERS Calabria MOLLACE VINCENZO AIDS and Related Research NeuroAIDS and other End organ Diseases NAED NF kb signaling pathway,innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI Mastino Antonio Brain Disorders and Cell Death in CDIN Expression of estrogen receptors and neuroglobin as a new tool to assess stratification of Parkinson's disease patients Piemonte Lopiano Leonardo Brain Disorders and and CNN A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Istituto Zooprofilattico Sperimentale della Sicilia Vaccari Gabriele Veterinary Animal Health ANHE A NEW CARE MODEL TO MAINTAIN FUNCTION IN STROKE PATIENTS:EARLY THERAPEUTIC PATIENT EDUCATION AND LONG TERM GROUP PHYSICAL ACTIVITY(e TEAM2011 : early Therapeutic Education Associated with Movement) ARCISPEDALE Tedeschi Claudio CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Evaluation of chemotherapy induced cardiotoxicity utilizing cardiac byomarkers doppler echocardiography and Magnetic Resonance Imaging Lazio Natale Luigi Brain Disorders and and CNN IMmunity, Inflammation and Carotid ATherosclerosis: the IMICAT study MONZINO Tremoli Elena Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS Pagina 124 di 167

125 Visual function in newborn at term and preterm at risk of brain damage: a new neonatal assessment visual european grid and correlations with neurodevelopmental outcome at short term (Naveg Project) MONDINO Fazzi Elisa Maria CLI Integrative, Functional, and Cognitive Central Visual Processing CVP SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche Michelucci Roberto Brain Disorders and Acute Neural Injury and Epilepsy ANIE PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Lombardia Ettore Beghi CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM Epigenetic alterations in nicotine and alcohol dependence Emilia Romagna Zoli Michele Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] Lazio Galiuto Leonarda CLI Cardiovascular and Myocardial Ischemia and Metabolism MIM Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Toscana Miccoli Paolo Oncology 2 Drug Discovery and Molecular Pharmacology DMP Effectiveness of cognitive remediation in schizophrenia: a prospective, multicenter study in the "real world" setting of Italian psychiatric services Lombardia Vita Antonio CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Biological and biomechanical experimentation using a new vetro ceramic scaffold for bone regeneration in order to evaluate surgical and pharmacological treatments before testing on the patient. Piemonte Schierano Gianmario Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems MABS Pagina 125 di 167

126 IMPROVEMENT OF BREAST CANCER THERAPY BY USING NANOVECTOR DELIVERY SYSTEMS Istituto Superiore di Sanita' Calcabrini Annarica Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT relevance of detecting EpCAM+ tumour cells in peripheral blood and in bone marrow in patients with hepatocellular carcinoma Piemonte SALIZZONI MAURO CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Friuli Venezia Giulia Struzzo Pierluigi CLI Healthcare Delivery and Health Services Organization and Delivery HSOD The early identification of the free radical disease of the newborn. New therapeutic strategies. Toscana BUONOCORE GIUSEPPE CLI Healthcare Delivery and Nursing Science: Children and Families NSCF Proposal for a multidisciplinary integrated approach to the health management of myotonic dystrophy type 1 (DM1) SAN RAFFAELE PISANA Silvestri Gabriella CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Multiplex Ligation Probe Amplification (MLPA) analysis, 5p 13.2 Loss Of Heterozygosity (LOH),CA SSR1 EGFR microsatellite analysis and NIPBL Illumina Solexa sequencing in Thymic Epithelial Tumors and Squamous Cell Lung Carcinomas metastatic to the medias REGINA ELENA MARINO MIRELLA Oncology 1 Basic Cancer Genetics CG Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. Toscana Silvestri Stefano Population Sciences and Epidemiology Epidemiology of Cancer EPIC Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Lombardia Pesenti Antonio CLI Cardiovascular and Lung Injury, Repair, and Remodeling LIRR Pagina 126 di 167

127 DEVELOPMENT IN ACUTE MYELOID LEUKEMIA PATIENTS OF A GENOMIC TEST BASED ON PROFILING OF APOPTOTIC MACHINERY AND OF mi RNA FOR REFINEMENT OF PROGNOSTIC RISK CLASSIFICATION AND TO GUIDE POST REMISSIONAL THERAPEUTIC STRATEGY Sicilia MILONE Giuseppe France Oncology 2 Cancer Biomarkers CBSS Development and validation of a simple and wearable new system for monitoring sleep and respiratory variables Toscana Bonanni Enrica CLI Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Pichierri Pietro Oncology 1 Basic Cancer Genetics CG Exploring the role of the HIV integrase inhibitor Raltegravir as a treatment of Secondary Progressive Multiple Sclerosis. Istituto Superiore di Sanita' palmisano lucia Brain Disorders and and CNN Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Nannipieri Monica Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO HIGH THROUGHPUT TECHNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC MARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) Puglia Schena Francesco Paolo Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK Predictive value of heart rate viariability in fetuses of high risk pregnancies. Development of a new method for accurate and rapid signal detection and analysis. Friuli Venezia Giulia Rizzo Giuseppe CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN An Innovative Microchip based Deep Brain Stimulation Device for Improved Treatment and Rehabilitation of Parkinson s Patients GALEAZZI Servello Domenico Brain Disorders and and CNN Pagina 127 di 167

128 Identification of prognostic and predictive serum biomarkers for monitoring type 1 diabetes risk and progression in humans Toscana DOTTA FRANCESCO Immunology Hypersensitivity, Autoimmune, and Immune and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Toscana Stampacchia Giulia CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach Ghia Paolo Prospero Oncology 1 Basic Cancer Genetics CG Prostate cancer and visceral obesity: an epidemiological, hormonal, metabolic and molecular study Veneto ZATTONI FILIBERTO CLI Digestive, Kidney and Urological Systems Urologic and Kidney Development and Genitourinary Diseases UKGD New nanotools for permeabilization of Brain Blood Barrier and early detection of Alzheimer disease NEUROMED Rosato Nicola Emerging Technologies and Training in s Pharmacology and Diagnostics for Neuropsychiatric Disorders and Neural Systems Small Business SBPD WIRVA Wireless control of Internal Routes and Vital signs monitoring for patients moving within hospital Areas Sicilia Pantò Aurelio Healthcare Delivery and Biomedical Computing and Health Informatics BCHI The Salivary Proteomics biomarkers for Alzheimer's disease study (SaP AD study) Sicilia Monastero Roberto Brain Disorders and and CNN THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA Toscana PINZANI MASSIMO Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 128 di 167

129 DEVELOPMENT OF A THYROID CANCER DATABASE TO IMPROVE THE QUALITY OF CLINICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Lazio BELLANTONE ROCCO DOME CLI Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] Multimodal approach to the presurgical evaluation of drug resistant epilepsy S.CAMILLO Manganotti Paolo CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Personalized and optimized Road Map of effective integration between intensive medical treatment and secondary liver surgery in liver limited metastatic colorectal cancer (MCRC) through biomolecular characterization. Abruzzo Ricevuto Enrico Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] Accuracy and clinical impact of 68 Ga labeled octreotide analogues PET in diagnosis and staging of duodenopancreatic neuroendocrine tumours; proposal of a multicenter, prospective, non randomized clinical trial. ARCISPEDALE Camellini Lorenzo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Vitamin D and Myasthenia Gravis: from the animal model to the human disease CARLO BESTA Antozzi Carlo Brain Disorders and Neuroimmunology and Brain Tumors CNBT Comparative efficiency and risk assessment of grafting human gabaergic neural precursors from different sources in experimental models of Huntington disease. SAN MATTEO Magrassi Lorenzo Brain Disorders and and CNN Value of MR combined Imaging in assessment of early response to neoadjuvant theraphy in Locally Advanced Breast Cancer PASCALE Petrillo Antonella Oncology 2 Oncology CONC Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA Filippini Graziella CLI Brain Disorders and and CNN Pagina 129 di 167

130 Characterization of anal HPV infection and associated lesions in immunocompetent and immunocompromised hosts. SAN GALLICANO GIULIANI MASSIMO Oncology 1 Basic Cancer Etiology CE ADJUSTING THE ENVIRONMENTAL CONTEXT TO IMPROVE SEROTONINERGIC ANTIDEPRESSANT EFFICACY Istituto Superiore di Sanita' Branchi Igor Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health MESH Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Dottori MIchele Veterinary Animal Health ANHE Food pyramids and nutritional prevention campaigns CROB Galasso Rocco Healthcare Delivery and Health and Health Related Behavior of Individuals and Populations Fellowship F GABAergic modulation of resting state and stimulusinduced activity within the default mode network: a translational investigation on depression. SANTA LUCIA Puglisi Allegra Stefano Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Next generation approaches to identify novel pathophysiological mechanisms of coronary intra stent thrombosis and intra stent restenosis Toscana Giusti Betti Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Reducing the need for intensive care unit in hospitalized patients with early respiratory failure using the noninvasive ventilation technique. A multicentre randomized study. landoni giovanni CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Metal ions levels in symptomatic and asymptomatic patients with metal on metal replacement Lombardia APOSTOLI PIETRO CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM1 Pagina 130 di 167

131 Gene therapy for thalassemia: preclinical studies of efficacy and safety Ferrari Giuliana Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Markers of gluten sensitivity in unipolar and bipolar disorders Toscana PORCELLI BRUNETTA CLI Immunology Hypersensitivity, Autoimmune, and Immune A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. Bonini Maria Chiara Oncology 2 Cancer Immunopathology and Immunotherapy CII Ingestible device for the intragastric treatment of Helicobacter pylori infection Toscana Orsini Barbara Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR strategy for developing rationale combinations of molecularly targeted agents in patients with non Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) HUMANITAS Carlo Stella Carmelo Oncology 2 Developmental Therapeutics DT GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinson s Disease SAN RAFFAELE PISANA Babiloni Claudio CLI Brain Disorders and and CNN PREDICTION OF AWAKENING FROM ACUTE COMA USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS AND PAIN RELATED FUNCTIONAL BRAIN MAGNETIC RESONANCE. Veneto Zanatta Paolo CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Nociceptin/Orphanin FQ as a biomarker for Parkinson s disease Friuli Venezia Giulia Eleopra Roberto CLI Brain Disorders and and CNN Pagina 131 di 167

132 Identification and characterization of new SHOX related and SHOX unrelated mutations by Next Generation Sequencing analysis and pharmacogenomics evaluation of rhgh treatment Emilia Romagna Iughetti Lorenzo CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Protein profile of red blood cell and exosomes signature for early diagnosis of ovarian cancer Veneto Gion Massimo Oncology 2 Cancer Biomarkers CBSS Inflammation and cancer: relevance of chemokines in myeloid cells recruitment, activation and cross talk with NK cells in tumor biology HUMANITAS Bonecchi Raffaella Immunology Innate Immunity And Inflammation III Dietary patterns in midlife and occurrence of Alzheimer disease in old ages Lombardia Russo Antonio Giampi CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME Understanding the function of WRNIP1 in the maintenance of common fragile site stability and in lung cancer development Istituto Superiore di Sanita' Franchitto Annapaola Oncology 1 Basic Cancer Genetics CG Effectiveness and cost effectiveness of eating disorder networks in Italy Emilia Romagna brunetti massimo CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Adverse Health Effects of Airborne Particle Pollution: a multidisciplinary study IRCCS AOU San Martino IST (Genova) Merlo Domenico Franc Population Sciences and Epidemiology Epidemiology of Cancer EPIC Neurobiological, pharmacological and clinical studies on Attention Deficit Hyperactivity Disorder (ADHD): from patients to animal models and back. STELLA MARIS Masi Gabriele Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS STem cells Mobilization in Acute Myocardial Infarction Outcome Trial (STEM AMI OUTCOME Trial): efficacy and functional substudies Lombardia Achilli Felice CLI Cardiovascular and Myocardial Ischemia and Metabolism MIM Pagina 132 di 167

133 In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies Istituto Superiore di Sanita' Calamandrei Gemma Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER New candidate gene for hemiplegic migraine and episodic ataxia Lazio Buzzi Maria Gabriella Genes, Genomes and Genetics Genetics of Health and Disease GHD Collaborative model for the psychosocial care of the adult cancer patients and their caregivers: cluster, randomized trial to test a new way of care coordination. (HuCare 2: Humanization of cancer care, project 2) Lombardia Passalacqua Rodolfo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Mitochondrial dysfunction in ALS : a study of novel molecular partners as targets for therapeutic interventions Emilia Romagna Pinton Paolo Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Enhancing Transparency of Reporting of Systematic Reviews to Improve Health Care Emilia Romagna D'Amico Roberto Healthcare Delivery and Biostatistical Methods and Research Design BMRD Pain in post surgical hip and knee rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain free therapeutic algorithm. DON GNOCCHI cecchi francesca CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Nutritional factors in Rett syndrome and autism spectrum disorders: preclinical evaluation of dietary choline during early developmental phases Istituto Superiore di Sanita' Ricceri Laura Brain Disorders and Developmental Brain Disorders DBD DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' Dogliotti Eugenia Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis Istituto Superiore di Sanita' Boirivant Monica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology GMPB Pagina 133 di 167

134 Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI Porta Mauro Brain Disorders and and CNN Reducing the costs associated to post stroke rehabilitation: a novel robot assisted treatment protocol Veneto MASIERO STEFANO CLI Emerging Technologies and Training in s Sensory, Motor and Cognitive Fellowship F02B The treatment adherence in children and adolescents with Spina Bifida and neurogenic bladder: relations with demographic, medical, occupational, cognitive and psycho social variables. Lombardia SPINELLI MICHELE CLI Healthcare Delivery and Community Level Health Promotion CLHP CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY:A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' Di Bonito Paola Immunology Immunity and Host Defense IHD Sonochemotherapy. A new combined approach of sonoporation plus chemotherapy for the treatment of poorly chemosensitive cancers. Emilia Romagna PIscaglia Fabio Oncology 2 Developmental Therapeutics DT Association of all trans retinoic acid (ATRA) and trastuzumab for HER 2 positive metastatic breast cancer: a phase II evaluation of ATRA potential immunomodulatory activity for myeloid derived suppressor cells (MDSC). I. O. V. Ghiotto Cristina CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Four dimensions augmented reality navigation system for medical interventions CASA SOLLIEVO SOFFERENZA Beomonte Zob Bruno CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ARLORIO MARCO Veterinary Food Safety FOSA Pagina 134 di 167

135 Exercise and inflammation in obesity. Evaluation of relationships and possible interventions. (ObInEx Project) DON GNOCCHI Veicsteinas Arsenio Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes IPOD A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis Rampoldi Luca Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK The effect of moderate aerobic activity (fitwalking) on the metabolic and cardiovascular complications induced by antiretroviral therapy in patients with HIV infection Cinque Paola Maria CLI AIDS and Related Research AIDS Studies and Epidemiology ACE Performance of serum SMRP as screening tool (the cancer predictive values of SMRP ) surveilling a cohort of asbestos exposed individuals Liguria Mencoboni Manlio CLI Oncology 2 Cancer Biomarkers CBSS Pancreatic Islet Cell Transplantation for Treatment of Type 1 Diabetes ONCOLOGICO DI BARI GADALETA COSMO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Liver Factory SAN MATTEO Dionigi Paolo Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT MicroRNAs as molecular biomarkers for early detection of sporadic Fronto temporal Dementias Umbria Mecocci Patrizia Brain Disorders and and CNN Human Autologous Cardiospheres For The Treatment Of Paediatric Heart Failure OSPEDALE BAMBINO GESU' Amodeo Antonio CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Dysregulated RNA metabolism in multiple myeloma. Tonon Giovanni Oncology 1 Basic Molecular Oncogenesis MONC Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation of prevention strategies. Istituto Zooprofilattico Sperimentale del Mezzogiorno Suffredini Elisabetta Veterinary Food Safety FOSA Pagina 135 di 167

136 Role of Innate Immunity, Inflammasome and RAAS in the progression of type 2 diabetes through the regulation of hepatic, cardiovascular and endothelial function Lazio Lauro Davide Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes IPOD THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia Citerio Giuseppe CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Etiopathogenetic, diagnostic and prognostic role of hypermethylation and downregulation of IRX1 gene inducedby H. pylori infection in patients with gastric cancer. Tamburini Andrea Marco CLI Oncology 2 Cancer Biomarkers CBSS Role of chest physical examination to identifiy patients with early idiopathic pulmonary fibrosis: a multicenter prospective study Emilia Romagna Richeldi Luca CLI Cardiovascular and Small Business Activities ZRRS A longitudinal study to evaluate personality and mood disorders in patients with Multiple sclerosis SANTA LUCIA Nocentini Ugo CLI Brain Disorders and and CNN GENE EXPRESSION PROFILING IN HUMAN ACTH SECRETING PITUITARY TUMORS IN ASSOCIATION WITH CLINICAL AND CHEMICAL FEATURES. AUXOLOGICO Pecori Giraldi Francesca Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology MCE A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. MAGGIORE Priori Alberto CLI Brain Disorders and and CNN Randomized Trial Of Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy In Peritoneal Carcinomatosis Arising From Colorectal Cancer ARCISPEDALE Ponzano Cecilia CLI Oncology 2 Oncology CONC Innovative biomarkers for prevention, diagnosis and prognosis of colorectal cancer ARCISPEDALE Sassatelli Romano Oncology 2 Cancer Biomarkers CBSS Pagina 136 di 167

137 Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Lazio FORASTIERE FRANCESCO CLI Population Sciences and Epidemiology Cardiovascular and Sleep Epidemiology CASE Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Avolio Luigi Digestive, Kidney and Urological Systems Urologic and Kidney Development and Genitourinary Diseases UKGD Prevalence of Neonatal Adverse Outcomes and Their Risk Factors and Study on Adverse Medication Effects on the Newborn Health. Veneto Bortolus Renata CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Effect of intensive control of glycemia and associated cardiovascular ( CV ) risk factors on the evolution of severe psychiatric disorders. Emilia Romagna ZAVARONI DONATELLA CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano Wiedermann Christian CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery SANTA LUCIA Mattia Donatella CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Combined use of transcranial direct current stimulation and speech therapy to treat patients with aphasic stroke: short and long term effects on anomia MAUGERI Pistarini Caterina CLI Emerging Technologies and Training in s Neurophysiology, Devices, Auditory Devices and Neuroprosthesis Small Business SBNE Neurodegenerative disorders and tumors: epidemiologic and genetic investigation on their relationship. Sicilia aridon paolo CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME Strategies of psychological support in the context of clinical medical treatments aimed at preserving fertility in oncology, for women of childbearing age and girls of prepubertal age candidate for ovarian tissue banking. REGINA ELENA Cantelmi Tonino CLI Risk, Prevention and Health Behavior Psychosocial Risk and Disease Prevention PRDP Pagina 137 di 167

138 Targeting Hedgehog and Colony Stimulating Factor 1 pathways in triple negative breast cancers Toscana Stecca Barbara Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT From new cancer drug registries to appropriateness of care and determinants of (regional) variability: implementing a new monitoring system to evaluate evidence based guidelines Emilia Romagna Longo Giuseppe CLI Oncology 2 Oncology CONC Genome wide SNP identification for high resolution molecular genotyping of Listeria monocytogenes Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Parisi Antonio Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS HEART KIDNEY INTERACTIONS IN CHRONIC AND ACUTE DECOMPENSATED HEART FAILURE Emilia Romagna Montanari Alberto Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR The impact of depressive disorders on endothelial progenitor cells in patients with ischemic heart disease Toscana Pini Stefano Cardiovascular and Myocardial Ischemia and Metabolism MIM Potential relevance of HLA G, gelatinases and herpes viruses as markers of tumor invasion and progression and their association with CT and MRI perfusion findings in patients with high grade glioma Emilia Romagna FAINARDI ENRICO Brain Disorders and Neuroimmunology and Brain Tumors CNBT THE DOMOTIC GERIATRICS UNIT (DOMO_GER): AN INTELLIGENT SENSOR NETWORK FOR THE PREVENTION OF NEGATIVE OUTCOMES (DELIRIUM, FALLS, SUDDEN DEATH) IN HOSPITALIZED OLDER PATIENTS. Veneto Pilotto Alberto Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD Investigation of a novel engineered probiotic to treat Clostridium difficile infection Furci lucinda Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP Pagina 138 di 167

139 Role of oncogene induced senescence in thyroid carcinogenesis ISTITUTO TUMORI MILANO Greco Angela Oncology 1 Basic Cancer Molecular Pathobiology CAMP Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration FATEBENEFRATELLI Frisoni Giovanni Brain Disorders and and CNN and Molecular aspects of Sunitinib related hyperlipidemia. Toscana Mazzanti Roberto Oncology 2 Drug Discovery and Molecular Pharmacology DMP Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood Abruzzo Calabrese Giuseppe Genes, Genomes and Genetics Genetics of Health and Disease GHD Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments MONDINO Alfonsi Enrico CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Biological aging in dilated cardiomyopathy and chronic obstructive pulmonary disease Veneto Maestrelli Piero Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Evaluation of the effectiveness of ADL based exercises Vs point to point reaching tasks in robot mediated therapy of the upper limb for sub acute stroke patients SAN RAFFAELE PISANA Sterzi Silvia CLI Emerging Technologies and Training in s Brain Disorders and Related s Fellowship F Clinic evaluation of Cervista(TM)HR HPV as Screening Test Abruzzo MACCALLINI VINCENZO CLI Interdisciplinary Molecular Sciences and Training Fellowship: Oncological Sciences F Emerging and Re emerging Viral Infections in the Tuscany Region Toscana Ceccherini Nell Luca Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship F13 Pagina 139 di 167

140 DIGITAL KIDS Emilia Romagna BIASUCCI GIACOMO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia Felisati Giovanni CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Evaluation of the role of CD 133+/CD44+ colorectal TICs in patterns of metastatization and possible subsequent their clinical investigation ONCOLOGICO DI BARI Silvestris Nicola Oncology 2 Developmental Therapeutics DT DELIVERY OF THERAPEUTICAL AGENTS INTO MELANOMA BY TGF β SWITCH DEPENDENT HOMING OF MESENCHYMAL STEM CELLS (MSC), ENDOTHELIAL PROGENITOR CELLS (EPC) AND ANTIGEN PRESENTING CELLS (APC) Toscana Pimpinelli Nicola Oncology 1 Basic Tumor Progression and Metastasis TPM Gender specific oncology: psychoncology s contribution to global care and rehabilitation of young adult male and female patients C.R.O. AVIANO Annunziata Maria Antoniett CLI Oncology 2 Oncology CONC THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS MONDINO Cereda Cristina Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Efficacy of nicotine dependence pharmacotherapy based on individual pharmacokinetic profile and identification of pharmacogenetic determinants of drug response Toscana Pistelli Francesco CLI Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS Effect of exposure to environmental and food contaminants, on bone and liver diseases. Istituto Zooprofilattico Sperimentale del Mezzogiorno Colao Annamaria Veterinary Food Safety FOSA Pagina 140 di 167

141 Discovery of small molecules capable of eliminating the HIV T cellular reservoir Istituto Superiore di Sanita' Sgarbanti Marco AIDS and Related Research AIDS Discovery and Development of Therapeutics ADDT Study of three dimensional model analysis for evaluation of pelvic volume in patients with hemodynamic instability due to pelvic fracture. Emilia Romagna VALENTINO MASSIMO Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology BMIT PHENOTYPE GENOTYPE CORRELATION IN PATIENTS AFFECTED BY HYPOGONADISM: IMPLICATIONS FOR CLINICAL MANAGEMENT. Toscana Tonacchera Massimo Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction CMIR gene environment and gene gene association analyses on cognitive phenotypes in Italian nuclear families of dyslexia MEDEA marino cecilia Brain Disorders and Developmental Brain Disorders DBD CLINICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT RIZZOLI Bragonzoni Laura Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration SBSR Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolyl hydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy MAUGERI Esposito Ciro Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD Long term cancer survivors: a comparison between treatments and disease free persons and persons with active disease under therapeutic control. C.R.O. AVIANO Tirelli Umberto CLI Oncology 2 Oncology CONC Identification of novel biomarkers for Renal Cell Carcinoma early diagnosis by peptidome and exosome analysis Puglia Ranieri Elena Oncology 2 Cancer Biomarkers CBSS Homocysteine serum levels in patients with cutaneous lupus erythematosus: pathogenetic and therapeutic implications. Toscana Fabbri Paolo CLI Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Pagina 141 di 167

142 CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG FIVE IMPORTANT ACUTE HOSPITALS Toscana Tartaglia Riccardo CLI Risk, Prevention and Health Behavior Social Psychology, Personality and Interpersonal Processes SPIP System biology approach to define etiology and pathogenesis of idiopathic non histaminergic angioedema with normal C1 inhibitor Lombardia Cicardi Marco Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Human Cytomegalovirus (HCMV) specific T cell immunity monitoring and inflammatory response analysis in solid organ transplant recipients: from pathogenesis to clinical application Toscana De Luca Andrea CLI Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB Action and object observation treatment in acute stroke patients NEUROMED Buccino Giovanni Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Multidisciplinary Network for Chronic Pain Prevention. Interregional Model SAN MATTEO Guido Fanelli CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Targeting patients with recurrent depression and traumas: Comparison of the efficacy of EMDR and of CBT versus standard clinical management, their neurobiological correlates, and the associated health sanitary costs. Piemonte ostacoli luca CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA Identification of new molecular targets in preclinical models of cholangiocarcinoma and in tumor derived xenopatients Piemonte Aglietta Massimo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Role profiles and clinical competencies: a new approach for healthcare workforce Emilia Romagna Cicchetti Americo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 142 di 167

143 PHARMACOGENETICS OF PEMETREXED AND CARBOPLATIN IN MALIGNANT PLEURAL MESOTHELIOMA (MPM) PATIENTS. HUMANITAS Zucali Paolo Andrea Oncology 2 Cancer Biomarkers CBSS SUICIDE ATTEMPTS: FROM EPIDEMIOLOGY TO CLINICAL DIAGNOSIS Emilia Romagna Boncompagni Giancarlo CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress OSPEDALE BAMBINO GESU' Toietta Gabriele Vascular and Hematology Vascular Cell and Molecular Biology VCMB Functional BRAIN CHIP INTEGRATOR (fbci): A pilot study to implement novel rehabilitation strategies through neurochips technology in patients with disorders of consciousness. CARLO BESTA Leonardi Matilde CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA Scillitani Alfredo CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA bonanni paolo Brain Disorders and Developmental Brain Disorders DBD Impact of screening on survival in breast cancer patients: the role of tumor biology Toscana caldarella adele Population Sciences and Epidemiology Epidemiology of Cancer EPIC Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia Vancheri Carlo Cardiovascular and Lung Injury, Repair, and Remodeling LIRR Pagina 143 di 167

144 Chemical protection against ionizing radiation in subjects undergoing radiodiagnostic procedures: analysis of the role of natural compounds in a translational research plan Istituto Superiore di Sanita' fattibene paola Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM Major Depression in Systemic lupus erythematosus: a possible link between neurobiological aspects and biohumoral milieu Toscana Guazzelli Mario Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Novel immunotherapeutic strategies for the cure of human prostate cancer Mondino Anna Immunology Transplantation, Tolerance and Tumor Immunology TTT Development of novel gene therapy approaches to cure the primary ciliary dyskinesia Toscana Pifferi Massimo Cardiovascular and Lung Cellular, Molecular, And Immunobiology LCMI Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia Caputi Achille Patrizio CLI Population Sciences and Epidemiology Social Sciences and Population Studies SSPS IDENTIFICATION OF MOLECULAR MECHANISMS INVOLVED IN SYNOVIAL OSTEOCHONDROMATOSIS PATHOGENESIS Toscana Campanacci Domenico Andr Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD Near infrared technology for trafficking the fate of stem cells in vivo: a translational study for longitudinal tracking in a rodent model of Parkinson s disease AUXOLOGICO Cova Lidia Emerging Technologies and Training in s Neurotechnology NT HIV STDs coinfection in treated MSM patients: measurement of plasmatic and seminal HIV Viral Load Lombardia Gori Andrea CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Pagina 144 di 167

145 Effectiveness of multidisciplinary clinical approach and psychological treatment on enhanced recovery after surgery in patients with Inflammatory Bowel Diseases (IBD) Toscana Pavoni Vittorio CLI Risk, Prevention and Health Behavior Psychosocial Development, Risk, and Prevention PDRP GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS AS A DRUGGABLE TARGET TO DEVELOP A PHARMACOLOGICAL STRATEGY IN ALEXANDER DISEASE GASLINI Ceccherini Isabella Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROTICS Lombardia Bandera Alessandra CLI AIDS and Related Research AIDS Studies and Epidemiology ACE Identification of novel functional and biological parameters to predict the response to cardiac resynchronization therapy SAN MATTEO Ghio Stefano CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Investigation of link between Lung Cancer Stem Cells (CSCs) and Epithelial Mesenchymal Transition (EMT) for tumour progression and metastatis PASCALE Pirozzi Giuseppe Oncology 1 Basic Tumor Progression and Metastasis TPM Fluidodynamics of Fontan operation: A data base aiming at improvement of surgical outcome of the univentricular heart OSPEDALE BAMBINO GESU' Michielon Guido CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS COMPREHENSIVE APPROACH TO THE TREATMENT OF ATRIAL FIBRILLATION: NEW MULTIDISCIPLINAR FLOW CHART FOR EARLY DIAGNOSIS AND EARLY TREATMENT della bella paolo CLI Cardiovascular and Cardiovascular Sciences Small Business SECS NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana Berti Sergio CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 145 di 167

146 ROLE OF GENE POLYMORPHISMS IN PREDICTING EFFICACY AND TOXICITY IN DIFFUSE LARGE B CELL LYMPHOMA PATIENTS TREATED WITH R CHOP IMMUNOCHEMOTHERAPY Toscana Mini Enrico Oncology 2 Cancer Biomarkers CBSS Advanced diagnostics and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD). NEUROLESI Toscano Antonio CLI Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP Roles of ADP ribosylation in the regulation of the actin cytoskeleton and intracellular Ca2+ signaling Abruzzo Di Girolamo Maria Cell Biology Cellular Signaling and Regulatory Systems CSRS Development of methods to sub type Clostridium botulinum from animals to support epidemiological investigations and set up of a sera and vaccine bank for treatment and prevention of type C and D animal botulism Istituto Zooprofilattico Sperimentale delle Venezie Bano Luca Veterinary Animal Health ANHE Genetic characterization of supraventricular arrhythmias by whole exome sequencing Ferrari Maurizio Cardiovascular and Electrical Signaling, Ion Transport, and Arrhythmias ESTA Calcium sensitizer agents for improving organs protection in transplants. Piemonte Caimmi Philippe Primo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT MOLECULAR CHARACTERIZATION OF BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM MAGGIORE BERTI EMILIO Genes, Genomes and Genetics Molecular Genetics MGA Molecular modeling and functional analyses of EGFR for the selection of lung cancer patients eligible for targeted therapy with receptor kinase inhibitors ISTITUTO TUMORI MILANO tamborini elena Oncology 2 Developmental Therapeutics DT Identification of clinical and genetic factors for personalized opioid therapy of cancer pain ISTITUTO TUMORI MILANO CARACENI AUGUSTO CLI Oncology 2 Oncology CONC Pagina 146 di 167

147 LIMIT LOAD AND THE MECHANICAL RESPONSE TO THE PHYSIOTHERAPY TREATMENT OF THE NEURO MUSCULAR DEFICIENCY MAUGERI Springhetti Isabella CLI Bioengineering Sciences and Technologies Biomaterials and Biointerfaces BMBI Role of nicotinic receptor subtypes in alcohol tobacco dependence Emilia Romagna Pini Luigi Alberto Genes, Genomes and Genetics Genetics of Health and Disease GHD Integrated approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and long term auxological, neurodevelopmental and metabolic outcomes Piemonte Todros Tullia CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Viral respiratory tract infections in infants and young children: the IFNs/CD38/Ectonet axis as possible therapeutic target. Istituto Superiore di Sanita' Fedele Giorgio Immunology Innate Immunity And Inflammation III Transient Receptor Potential Canonical 1 (TRPC1) in pancreatic cancer: a new actor for NF kb inactivation CASA SOLLIEVO SOFFERENZA di Sebastiano Pierluigi Oncology 2 Drug Discovery and Molecular Pharmacology DMP IDENTIFICATION OF PHENOTYPE MODULATOR VARIANTS IN LAMIN A/C MUTATION CARRIERS BY EXOME AND GENOME SEQUENCING Benedetti Sara Genes, Genomes and Genetics Genetics of Health and Disease GHD Epitope mapping of Pru p 3 with multiple antigen or linear peptides: new approaches for the diagnosis and follow up of patients with severe IgE mediated reactions to food Toscana Caponi Laura Immunology Hypersensitivity, Autoimmune, and Immune ROLE OF micrornas IN THE PATHOGENESIS OF BARRETT S ESOPHAGOUS Sicilia Fiorentino Eugenio Oncology 2 Cancer Biomarkers CBSS A cooperative translational study focused on inflammation and eicosanoids to identify mechanism and predictors of preeclampsia Veneto Minuz Pietro Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Pagina 147 di 167

148 Obstructive sleep apnea as a cause of resistant hypertension: impact of CPAP treatment on blood pressure and number of antihypertensive medications FERINI STRA Luigi CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model Istituto Superiore di Sanita' Gabriele Lucia Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP The unawareness of illness and executive dysfunctions in bipolaroutpatients Piemonte keller roberto CLI Brain Disorders and and CNN and prognostic evaluation of thoracic aortic aneurysms: integration between MRI indexes, biological and biomechanical properties Toscana Bevilacqua Stefano Cardiovascular and and Integrative Cardiovascular Sciences CICS High detection of chronic kidney disease (CKD) in general population by combination of estimated glomerular filtration rate (GFR) and microalbuminuria Puglia Manno Carlo CLI Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities SERU Anaplastic lymphoma kinase (ALK) gene status assessment to improve treatment of pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO Pelosi Giuseppe CLI Oncology 2 Cancer Biomarkers CBSS THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Toscana Antoniucci David CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Evaluation of triethylamine / triethylamine oxidized (TMA / TMAO) in patients with autosomal dominant familial hypercholesterolemia (ADH) Sicilia Di Gaudio Francesca Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes INMP Pagina 148 di 167

149 Role of trace element in the pathogenesis of Multiple sclerosis Istituto Superiore di Sanita' Nicoletti Alessandra Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME A proteomic and lipidomic approach to discover diagnostic and predictive markers of lung cancer. Emilia Romagna Rossi Giulio Oncology 2 Cancer Biomarkers CBSS Study on the Mammalian Target of Rapamycin (mtor) signaling pathway as a potential antiepileptogenic therapy Calabria De Sarro Giovambattista Brain Disorders and Acute Neural Injury and Epilepsy ANIE HBV related chronic hepatitis: bone metabolism study in naïve patients and in long term therapy with nucleos(t)ide analogue Piemonte Durazzo Marilena CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Borrello Maria Grazia Oncology 1 Basic Tumor Cell Biology TCB Telemedicine for monitoring of asthmatic patients Evaluation of the outcome of treatment accordin to the style of life. OSPEDALE BAMBINO GESU' CUTRERA RENATO CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM A translational approach to hypertrophic cardiomyopathy: new therapeutic targets for a personalized drug therapy Toscana Olivotto Iacopo Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF and experimental investigations of novel disease mechanisms in pain processing and Parkinson Disease MONDINO Tassorelli Cristina Brain Disorders and and CNN Innovative procedures for Transcranial Magnetic Stimulation of neuro patients, also in vegetative state NEUROLESI vermiglio giuseppe Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Pagina 149 di 167

150 Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA Bertolino Alessandro Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA THE ROLE OF ALCOHOL USE IN PATIENTS WITH A FIRST EPILEPTIC SEIZURE IN DIFFERENT POPULATIONS. Piemonte Leone maurizio Angelo CLI Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology NAME In vivo manipulation of gamma delta T cells with zoledronate and low dose IL 2 for immunotherapy of malignant melanoma Sicilia Cordova Adriana CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Multiple Chronic Conditions Prevalence, Care Management, Implications for Quality, and Health Costs Lombardia Catapano Alberico Luigi CLI Healthcare Delivery and Health Services Organization and Delivery HSOD LOGICAL BANK TO IDENTIFY MARKERS OF DISEASE ACTIVITY RELATED TO CLINICAL VARIABLES AND MODIFYING DRUGS IN MULTIPLE SCLEROSIS Emilia Romagna Granieri Enrico CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Myocardial Fibrosis in Valvular Heart Disease Lazio Melina Giovanni CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack Istituto Zooprofilattico Sperimentale del Mezzogiorno Proroga Yolande Therese Veterinary Food Safety FOSA Impact of patient's and physician's gender on the prescriptions of cardiovascular and antidiabetic pharmacological agents in a community setting Toscana Ballo Piercarlo CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS In vitro and in vivo effects of post transplant cyclophosphamide as novel immunosuppressive regimen for hematopoietic stem cell transplantation from partially HLA matched donors IRCCS AOU San Martino IST (Genova) raiola annamaria Immunology Transplantation, Tolerance and Tumor Immunology TTT Pagina 150 di 167

151 Emerging contaminants in the feed food chain: integrated models to support risk analysis Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Abete Cesarina Veterinary Food Safety FOSA Exposure to low arsenic concentrations via drinking water and health effects in 91 municipalities of the Lazio region, Italy Lazio Michelozzi Paola Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Type 2 Diabetes Mellitus and Alzheimer's Disease: towards a common treatment? Piemonte RAINERO INNOCENZO CLI Integrative, Functional, and Cognitive Neurobiology of Learning and Memory LAM Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases Sitia Roberto Cell Biology Membrane Biology and Protein Processing MBPP Global prospective evaluation of the in vivo clinical efficacy and of the ex vivo bio mechanical properties of the biological meshes employed in thoracic abdominalpelvic wall reconstructive surgery. Veneto tiengo cesare Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS A study on the economic and social burden of Parkinson s Disease in Italy and a cost benefit analysis of disease modifying therapies. SAN RAFFAELE PISANA stocchi fabrizio CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Proteomics and metabonomics strategies to characterize functional biomarkers of Polycyclic aromatic hydrocarbons contamination on dairy products Abruzzo Sacchetta Paolo Veterinary Food Safety FOSA Glioblastoma multiforme long survivors: impact of molecular profile on prognosis Toscana taddei gian luigi Oncology 2 Cancer Biomarkers CBSS ROLE OF PERFUSION COMPUTED TOMOGRAPHY(PCT)AND VASCULAR ENDOTHELIAL GROWTH FACTOR A(VEGF A)SERUM LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS(HGG):NEW METHODS OF MONITORING TREATMENT? NEUROMED tomao silverio CLI Oncology 1 Basic Tumor Progression and Metastasis TPM2 Pagina 151 di 167

152 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) Bolognesi Claudia Oncology 1 Basic Cancer Etiology CE Pharmacogenomics of clopidogrel in acute coronary syndromes. Emilia Romagna Ardissino Diego CLI Cardiovascular and Cardiovascular Sciences Small Business SECS Development of predictive models based on clinical indicators, dosimetry and bioimaging to describe the dose effect due to laser treatment of skin cancer lesions SAN GALLICANO Bucher Stefania Oncology 2 Radiation Therapeutics and Biology RTB Assessment of left ventricular systolic and diastolic dysfunction in patients with pre clinical and overt heart failure. Sicilia Cipolla Tommaso CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia Avitabile Teresio CLI Interdisciplinary Molecular Sciences and Training Fellowship: Cell Biology and Development F Role of polymorphisms of genes involved in alloreactive response in kidney transplantation: implications for personalized post transplant therapies Abruzzo PAPOLA FRANCO Immunology Transplantation, Tolerance and Tumor Immunology TTT Impact of thrombophilia on risk of perinatal stroke in neonates: a prospective study OSPEDALE BAMBINO GESU' Luciani Matteo CLI Vascular and Hematology Hemostasis and Thrombosis HT Characterization of melanoma cells from primary and metastatic human melanoma in culture: prognostic and therapeutic implications Emilia Romagna Magnoni Cristina Oncology 1 Basic Tumor Progression and Metastasis TPM Molecular profiles in Male Breast Cancer (MBC) Sicilia RUSSO ANTONIO Oncology 2 Cancer Biomarkers CBSS Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients Bacchetta Rosa Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 152 di 167

153 Metabolomic analysis of primary immunodeficiency and its application to a low cost neonatal screening program. Toscana Azzari Chiara Immunology Cellular and Molecular Immunology B CMIB An endoscopic information system for the achievement and the distribution of clinical images and video associated to the surgical procedures Sicilia Russo Arcangelo Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Disease related biomarkers investigation in Multiple sclerosis by analysis of microvesicles isolated by CSF. Sicilia Ragonese Paolo Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND AN ALTERNATIVE APPROACH TO CLINICAL MANAGEMENT OF GESTATIONAL DIABETES Lombardia BONOMO MATTEO ANDR CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Validation of a new algorithm for HPV status assessment in head and neck carcinoma ISTITUTO TUMORI MILANO GLOGHINI Annunziata CLI Oncology 2 Cancer Biomarkers CBSS RANDOMIZED CONTROLLED TRIAL OF MULTIDIMENSIONAL STIMULATION THERAPY IN PRODROMAL TO MODERATE STAGES OF ALZHEIMER'S DISEASE: CLINICAL, FUNCTIONAL MRI ASSESSMENT AND COST EFFECTIVENESS ANALYSIS. DON GNOCCHI Nemni Raffello CLI Brain Disorders and and CNN Beneficial impact of Caribbean dances and Mediterranean diet on patients with cardiovascular risk Puglia Pertosa Giovanni CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Targeting MicroRNA profile in cancer associated angiogenesis: new therapeutical and prognostic tools. Abruzzo Giacomelli Roberto Oncology 2 Developmental Therapeutics DT FRACTURE UNIT MULTIREGIONAL EXPERIMENTATION PROJECT (FRAME Project) Toscana BRANDI MARIA LUISA CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 153 di 167

154 management of viral infections in pediatric hematopoietic stem cell transplant recipients. Piemonte Cavallo Rossana CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Old and new hypoglycemic agents and incidence of cancer in a large cohort of type 2 diabetic patients: the RIACE Study Toscana Anna Solini CLI Risk, Prevention and Health Behavior Psychosocial Risk and Disease Prevention PRDP Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) Uccelli Antonio Immunology Hypersensitivity, Autoimmune, and Immune Governance of diabetes management in non specialistic hospital settings. Emilia Romagna zavaroni ivana CLI Healthcare Delivery and Health Services Organization and Delivery HSOD CT scan evaluation of vertebral body derotation in adolescent idiopathic scoliosis surgery RIZZOLI Di Silvestre Mario CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Prof of Concept combination strategy for HIV prevention and control: does microbicide during vaccination impact on B cell immune responses? Scarlatti Gabriella AIDS and Related Research HIV/AIDS Vaccines VACC Characterization of the role of HIV1 Tat in establishment and maintenance of viral reservoirs: implications for new strategies toward HIV eradication Emilia Romagna SIGHINOLFI LAURA AIDS and Related Research AIDS Immunology and Pathogenesis AIP IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS Naldini Luigi Genes, Genomes and Genetics Gene Therapy and Inborn Errors GTIE Special Emphasis Panel Genotoxic effects related to pesticide exposure: a novel bio monitoring approach IRCCS AOU San Martino IST (Genova) Ceppi Marcello Population Sciences and Epidemiology Epidemiology of Cancer EPIC Longitudinal, comprehensive, integrated study of outcome in patients with prolonged disorders of consciousness (DOC) MAUGERI ESTRANEO ANNA CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Pagina 154 di 167

155 Multimodal evaluation of stroke patient's mindbrain state during upper limb robot aided therapy SAN RAFFAELE PISANA Rossini Paolo CLI Emerging Technologies and Training in s Brain Disorders and Related s Fellowship F PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO Pompilio Giulio CLI Cardiovascular and Myocardial Ischemia and Metabolism MIM HOME BASED COGNITIVE REHABILITATION AFTER BRAIN DAMAGE THROUGH VIRTUAL REALITY Lombardia BOTTINI GABRIELLA CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Olfactory dysfunction: neurophysiological, neuropsychological and functional magnetic resonance assessment for the early detection of Alzheimer's disease. Toscana Sartucci Ferdinando CLI Brain Disorders and and CNN Identification and validation of co morbidity scores and analysis of their impact on the fitness for treatment in patients with solid and haematological tumours HUMANITAS santoro armando CLI Healthcare Delivery and Research on Ethical Issues in Human Studies REHS Generation of artificial lymphoid organs with mutipotent stromal progenitors derived from induced pluripotent stem cells. Brendolan Andrea Biology of Development and Aging Development 1 DEV Thermalism role in the management of arthralgia in women treated with aromatase inhibitors Piemonte VARESE PAOLA CLI Oncology 2 Oncology CONC Long term efficacy of non pharmacological computer assisted treatment in Alzheimer s Disease and MCI (Mild Cognitive Impairment) patient Lombardia Galante Emanuela CLI Brain Disorders and and CNN Application of nanomechanical assays to detection of algal toxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia BERTASI BARBARA Veterinary Animal welfare ANWE Pagina 155 di 167

156 Health and equity effects of natural policy experiments in the fields of structural policies and health care organization Piemonte COSTA GIUSEPPE CLI Healthcare Delivery and Community Level Health Promotion CLHP Gio why not? A perspective observational study to improve early diagnosis of andrologic pathologies in young people. Lesma Arianna CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio Salvetti Marco CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Detailed virological characterisation of patients with virological failure receiving integrase inhibitors and/or CCR5 inhibitors: RNA and DNA resistance profile, plasma and cell viral load, V3 loop characterisation and pharmacokinetic profile Istituto Superiore di Sanita' Baroncelli Silvia AIDS and Related Research AIDS Immunology and Pathogenesis AIP Health Technology assessment on mesenchymal stem cells and growth factors in orthopedics and traumatology Agenzia per i Servizi Sanitari Regionali Gigante Antonio Pompili CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Semicarbazide sensitive amine oxidases (SSAOs) and matrix degrading metalloproteases (MMPs): a multidisciplinary study of their possible contribution to cerebral amyloid angiopathy (CAA) in Alzheimer's disease. SAN RAFFAELE PISANA Squitti Rosanna CLI Brain Disorders and and CNN RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY MAUGERI La Rovere Maria Teresa Cardiovascular and and Integrative Cardiovascular Sciences CICS How to evaluate Efficacy In the framework of costeffectiveness analysis for Growth Hormone (rhgh) Therapy in paediatric patients with Growth Hormone deficiency Piemonte Matarazzo Patrizia CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Pagina 156 di 167

157 Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana Camiciottoli Gianna CLI Cardiovascular and Small Business Activities ZRRS Physiological effects of extracellular guanosine triphosphate (GTP) on renal cells and water transport Abruzzo Pietrangelo Tiziana Cell Biology Molecular and Integrative Signal Transduction MIST Nanomedicine applied to cerebral ischemia NEUROLESI Osculati Francesco Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Role of mir 155 in FLT3 ITD mutated acute myeloid leukemia: studies of network, signalling and silencing. Sicilia Santoro Alessandra Oncology 1 Basic Cancer Molecular Pathobiology CAMP New paradigms for Tuberculosis (TB) management using rapid molecular detection of Mycobacterium tuberculosis and Rifampin resistance Emilia Romagna VIALE PIERLUIGI CLI Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship F Brain Tumor Banking: a tool for research, diagnosis and therapy MONDINO Schiffer Davide Oncology 1 Basic Cancer Molecular Pathobiology CAMP HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy. RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lombardia Squillace Nicola CLI AIDS and Related Research AIDS Molecular and Cellular Biology AMCB Lazio Matteocci Antonella Cell Biology Membrane Biology and Protein Processing MBPP Evaluation of Diagnostic Accuracy of DW and DCE Magnetic Resonance Imaging in the Mesorectal Nodes staging of Rectal Carcinoma ISTITUTO TUMORI MILANO Scaramuzza Davide Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI Autoimmune encephalopaties: better characterization of the antibody profile CARLO BESTA Andreetta Francesca CLI Brain Disorders and Neuroimmunology and Brain Tumors CNBT Pagina 157 di 167

158 Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI Manfrini Marco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ZRCM Combination of carfilzomib and pomalidomide, two last generation proteasome inhibitor and immunomodulating agents, for the treatment of patients with multiple myeloma relapsed after or refractory to lenalidomide: an international (EMNTG) phase I II clin CROB Palumbo Antonio Oncology 2 Cancer Biomarkers CBSS Evaluation of the pharmaco/toxicological profile of new smart drugs of abuse and optimization of targeted analytical procedures for their detection in biological samples Toscana Chericoni Silvio Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA MicroRNAs as potential therapeutic strategies to prevent adverse vascular events and increase angiogenesis after limb ischemia. Calabria INDOLFI CIRO Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with difficult diagnosis: Implications for Disease Definition, Diagnosis, and Treatment. ISTITUTO DERMOPATICO DELL'IMMACOLATA DE LUCA CHIARA CLI Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Identification of prevalence of urinary incontinence in breast cancer women in hormonal treatment. Identification of a diagnostic and therapeutic path. Toscana NICITA GIULIO CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Prevalence and clinical impact of Chronic Obstructive Pulmonary Disease (COPD) in patients with cardiovascular disease and predictive power of cardiovascular risk factors in patients with COPD SAN RAFFAELE PISANA Iellamo Ferdinando CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Pagina 158 di 167

159 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Altavilla Domenica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in the aetiopathogenesis of the Williams Beuren Syndrome. Pannese Maria Brain Disorders and Developmental Brain Disorders DBD The use of an innovative microarray platform into the clinical setting Sicilia Cavallaro Sebastiano Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Strategy of immunotherapy with specific T lymphocytes versus B cell acute lymphoblastic leukemia Piemonte Fagioli Franca Oncology 2 Cancer Immunopathology and Immunotherapy CII IntraOperative Imaging Technologies (IOIT): supporting decision making process in the Italian National Health Care System (NHS) Agenzia per i Servizi Sanitari Regionali Marchetti Marco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS implementation of Adaptive Radiotherapy (ART) head and neck cancer. Evaluation of ART IMRT potential in reducing xerostomia and dysphagia. I. O. V. Paiusco Marta CLI Oncology 2 Oncology CONC From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA Fazio Vito Michele Oncology 1 Basic Cancer Molecular Pathobiology CAMP Pagina 159 di 167

160 Long term Legionella control in hospital hot water distribution systems by water treatment with natural terpenoid based products: assessment of their antimicrobial and toxicological activities in batch, pilotplant and real scale conditions. Istituto Superiore di Sanita' Veschetti Enrico CLI Infectious Diseases and Microbiology Small Business: Non HIV Infectious Agent Detection/Diagnostic s, Food Safety, Sterilization/Disinfect ion and Bioremediation SBID Analysis of the clinical heterogeneity on a wide cohort of Rett patient through a biochemical and molecular approach AUXOLOGICO Russo Silvia Genes, Genomes and Genetics Genetics of Health and Disease GHD Heart failure specialist nurse services (HFSN) Marche Moretti Luciano CLI Healthcare Delivery and Health Services Organization and Delivery HSOD Negative pressure therapy : model of Haealth management Hospital to territory Veneto AZZENA BRUNO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT New therapeutic strategies for the control of fungal infections in the elderly Istituto Superiore di Sanita' Stringaro Annarita Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance DDR Develop of new whole body Dosemeter for measuring ionizing Radiation to Operators in medical practice and of STErilizable wrist dosemeter (DROSTE) Toscana Rossi Francesco CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Small Business Biomedical Imaging SBMI Quitline for smoking cessation in women adhering cervical cancer screening Piemonte Giordano Livia CLI Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA Development, Implementation and Evaluation of a Complex Program Focused on Quality of Life Assessment in the Palliative Care Network of the Ligurian Region IRCCS AOU San Martino IST (Genova) Catania Gianluca CLI Healthcare Delivery and Nursing Science: Adults and Older Adults NSAA IDENTIFICATION AND ANALYSIS OF MOLECULAR MECHANISM IN SPORADIC AND FAMILIAL FORMS OF CCM. NEUROLESI SIDOTI ANTONINA Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Pagina 160 di 167

161 Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody Istituto Superiore di Sanita' Campitelli Laura Immunology Immunity and Host Defense IHD The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Toscana Pantoni Leonardo CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Piemonte Ranieri V. Marco CLI Cardiovascular and Small Business Activities ZRRS Titanium based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO Benazzo Francesco Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE MITO 7 A Multicenter phase 3 Randomized Study with weekly paclitaxel in patients with Ovarian Cancer treated with first line chemotherapy PASCALE Pignata Sandro CLI Oncology 2 Oncology CONC Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? S.CAMILLO Venneri Annalena Brain Disorders and and CNN Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors. ISTITUTO TUMORI MILANO Sensi Marialuisa Oncology 1 Basic Tumor Cell Biology TCB Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non invasive biomarkers in colon and rectal cancer I. O. V. Pucciarelli Salvatore Oncology 2 Cancer Biomarkers CBSS IDENTIFICATION OF GENETIC RISK FOR MELANOMA AND CANCERS OTHER THAN MELANOMA IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA SAN MATTEO Borroni Giovanni CLI Oncology 1 Basic Cancer Genetics CG Pagina 161 di 167

162 CIRCULATING ANTI TRANSGLUTAMINASE ANTIBODIES: A NOVEL MARKER OF RECURRENT ABORTION AND A KEY INFLUENCER OF NEO ANGIOGENESIS Molise gasbarrini antonio Cell Biology Cellular Signaling and Regulatory Systems CSRS Endothelial Dysfunction and Insulin Resistance: an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signaling and cardiovascular damage Toscana Natali Andrea Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Novel POCT device for sepsis diagnosis based on a multiassay optical biochip Toscana Metelli Maria Rita Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD Microvesicles as mediators of cell to cell interaction in hematological malignancies: biological characterization and clinical relevance in Chronic Lymphocytic Leukemia and Myelodysplastic Syndrome Piemonte Tarella Corrado Oncology 2 Cancer Biomarkers CBSS Role of peritoneal dialysis in the treatment of refractory heart failure Puglia IACOVIELLO MASSIMO CLI Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF Proteomics and transcriptomics studies to define a new role of REP1: insights in the molecular pathogenesis of Choroideremia SDN esposito gabriella Cell Biology Biology and Diseases of the Posterior Eye BDPE Ovarian serous carcinoma:identification of prognostic and predictive markers and risk assessment. Calabria Costanzo Francesco Oncology 1 Basic Cancer Molecular Pathobiology CAMP Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Toscana Lombardi Massimo CLI Cardiovascular and Myocardial Ischemia and Metabolism MIM A randomized multi center study for the evaluation of efficacy and safety of two different daily doses of low molecular weight heparin (LMWH) in subjects with cancer and incidentally detected non symptomatic pulmonary embolism SAN MATTEO Piovella Franco CLI Cardiovascular and Cardiovascular Sciences Small Business SECS Pagina 162 di 167

163 Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Marenzi Giancarlo Cardiovascular and and Integrative Cardiovascular Sciences CICS Citicoline treatment for traumatic brain injury NEUROLESI Bramanti Placido CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure AUXOLOGICO Parati Gianfranco CLI Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department Toscana Di Bari Mauro CLI Healthcare Delivery and Health Services Organization and Delivery HSOD IDENTIFICATION OF NEURODEVELOPMENTAL RISK FACTORS FROM GESTATION TO BIRTH: PRENATAL DIAGNOSIS OF NEUROLOGICAL DISEASE, MANAGEMENT IN NICU AND EARLY REHABILITATION CARE.ESTABLISHMENT OF A MULTIDISCIPLINARY DIAGNOSTIC AND THERAPEUTIC PATHWAY FOR THE NEWBO Sicilia trapolino emanuele CLI Brain Disorders and Developmental Brain Disorders DBD Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines Toscana Moriondo Maria Immunology SBIR none HIV Polymeric films and magnetic forces for gallbladder retraction during a fully translumenal cholecystectomy Piemonte AREZZO ALBERTO Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Integrated approach to investigate the effect of environmental pollution on reproductive outcomes Emilia Romagna Colacci Annamaria Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Pagina 163 di 167

164 Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCV associated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA Fiorilli Massimo Oncology 1 Basic Molecular Oncogenesis MONC Custom made devices for bone regenerative medicine. RIZZOLI Grigolo Brunella Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE A randomized intervention study to assess the effect of the Mediterranean Diet on plasma fatty acid profile. MONZINO VEGLIA FABRIZIO CLI Cardiovascular and and Integrative Cardiovascular Sciences CICS Development of a new synthetic coronary bypass graft for coronary artery bypass grafting Toscana GLAUBER MATTIA Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS BDNF polymorphism, calprotectin and clinical phenotype in Rett syndrome Toscana DE FELICE CLAUDIO CLI Brain Disorders and Developmental Brain Disorders DBD The use of a numerical model of the cardiovascular system to personalize and optimize cardiac resynchronization therapy (CRT) Lazio Romeo Francesco Cardiovascular and Cardiac Contractility, Hypertrophy, and Failure CCHF CLINICAL IMPACT OF TISSUE AND CIRCULATING MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF THYROID CANCER Toscana Pupilli Cinzia CLI Oncology 2 Cancer Biomarkers CBSS Exposure to occupational carcinogens and pathogenetic mechanisms in sinonasal adenocarcinomas Piemonte d'errico Angelo CLI Oncology 1 Basic Molecular Oncogenesis MONC EVALUATION OF THE ROLE OF HPV INDUCED IMMUNE RESPONSE IN VACCINE RELATED EFFICACY: COMPARISON BETWEEN BIVALENT AND QUADRIVALENT HPV VACCINES IN FEMALES AND MALES MAGGIORE Torresani Erminio Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM1 Pagina 164 di 167

165 THERAPEUTIC DEVICE OF AREA FOR ADOLESCENCE WITH SEVERE PSYCHIATRIC DISORDERS. PROSPECTIVE STUDY ON EFFICACY. Lombardia BOLCHI GIANLUCA CLI Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes BMIO Studies on the cardiovascular effects of mandibular stretching and on their potential application in the treatment of arterial hypertension Toscana Ghione Sergio CLI Cardiovascular and Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Purification and utilization of adult adipose derived mesenchymal stem cells (ADMSC) from rat adipose tissue and their transdifferentation toward endothelial cells for kidney function recovery Istituto Zooprofilattico Sperimentale della Sicilia Damiano Giuseppe Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities SERU Pharmacoepidemiology, pharmacosurveillance and identification of predictive factors of oxaliplatin neurotoxicity in colorectal cancer: development and validation of a prognostic score Toscana Mazzei Teresita Oncology 2 Cancer Biomarkers CBSS Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach Comi Giancarlo CLI Brain Disorders and and CNN An integrated pharmacogenetic approach to the optimization of adjuvant hormonal treatment of estrogen receptor positive breast cancer Toscana Danesi Romano Oncology 2 Cancer Biomarkers CBSS Metabolic syndrome and liver cancer: surveillance program on large population in Veneto Veneto Iacono Calogero CLI Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan TPM TREATMENT OF EARLY STAGE (I II) OROPHARYNGEAL CANCER WITH TRANSORAL ROBOTIC SURGERY VERSUS ESCLUSIVE RADIOTHERAPY: PROSPECTIVE MULTICENTER RANDOMIZED STUDY. I.E.O. Ansarin Mohssen CLI Oncology 2 Oncology CONC Pagina 165 di 167

166 CENTRAL EFFECTS OF BOTULINUM NEUROTOXINS: THERAPEUTIC IMPLICATIONS Toscana CALEO MATTEO Brain Disorders and Neuroplasticity and Neurotransmitters CNNT Enhancing the efficacy and the efficiency of obesity treatment through the psicological assessment of obese patients. Piemonte cardetti silvia CLI Risk, Prevention and Health Behavior Psychosocial Risk and Disease Prevention PRDP Proteomic salivary analysis and a mathematical model for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis. Toscana bazzichi laura Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS How to personalize the classic and atypical antipsychotic therapy in elderly patients affected by dementia: a pharmacogenetic study. Piemonte Fantò Fausto Brain Disorders and Developmental Brain Disorders DBD TISSUE PATCH ENGINEERING OF ADIPOSE DERIVED STEM CELLS FOR MEDICAL DEVICES. MAGGIORE TORRENTE YVAN Bioengineering Sciences and Technologies Gene and Drug Delivery Systems GDD Prevention of recurrence of idiopathic calcium stones and risk of developing associated diseases: a study of saltsensitivity genetics, urinary phenotype risk and body composition. Emilia Romagna MESCHI TIZIANA CLI Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD Association between Chronic Obstructive Pulmonary Disease and lung cancer: mechanisms of immune regulation Veneto Saetta Marina Cardiovascular and Lung Cellular, Molecular, And Immunobiology LCMI STUDIES OF NEOPLASTIC PREVALENCE IN SINATHROPUS ANIMALS LIVING ON NATIONAL INTEREST SITES(SIN)IN CAMPANIA REGION AND EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENTAL ONCOLOGICAL RISKS Istituto Zooprofilattico Sperimentale del Mezzogiorno DEGLI UBERTI BARBARA Veterinary Animal Health ANHE The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Emilia Romagna FEO CARLO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 166 di 167

167 Analysis of epidemiology and molecular characteristics of emerging salmonella serovars in Italy Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Pongolini Stefano Veterinary Food Safety FOSA Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana Amedei Amedeo Oncology 1 Basic Tumor Microenvironment TME DETECTION OF C KIT ; BRAF AND N RAS MUTATION IN NAIL MELANOMA Emilia Romagna Balestri Riccardo Genes, Genomes and Genetics Genetics of Health and Disease GHD Possibility to calculate the 131I activity based on the desired thyroid mass reduction in the radionuclide therapy of Graves' disease Toscana Mariani Giuliano CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F An Italian multidisciplinary clinic for Wolfram Syndrome GASLINI d'annunzio Giuseppe CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Assessment and longitudinal monitoring of thymic output and immune status in the 22q11.2 deletion syndrome Toscana CONSOLINI RITA Immunology Hypersensitivity, Autoimmune, and Immune Benefits of cognitive training in healthy older adults after identification of risk factors for neurodegeneration MAGGIORE Zago Stefano CLI Biology of Development and Aging Aging Systems and Geriatrics ASG Pagina 167 di 167