Ministero della Salute

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1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA Elenco Progetti Collaborazione con Ricercatore Italiano All'Estero Presentati Development of new strategies to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, genetic and epigenetic analysis Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise D'Addario Claudio Molecular, Cellular, and Developmental Molecular Neuropharmacology and Signaling MNPS Impact of influenza vaccination in HIV 1 multi treated elderly patients Istituto Superiore di Sanita' Michelini Zuleika AIDS and Related Research AIDS Immunology and Pathogenesis AIP DERMATOLOGIC PROBLEMS IN ONCOLOGICAL PATIENTS. A PREVENTIVE AND THERAPEUTIC APPROACH SAN GALLICANO Mariano Maria Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Targeting Histone Acetylation as a Approach to Cancer Therapy REGINA ELENA Trisciuoglio Daniela Oncology 2 Drug Discovery and Molecular Pharmacology DMP Fighting Alzheimer: new prospectives and therapeutical strategies SANTA LUCIA Matrone Carmela Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Mesenchymal stem cells and islet co transplantation in diabetic rats: natural chemistry and physical Energy to improve graft revascularization and function by human adipose derived stem cells Emilia Romagna Bianchi Francesca Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Role of Mcl 1 protein in tumor angiogenesis and progression REGINA ELENA Gabellini Chiara Oncology 1 Basic Tumor Progression and Metastasis TPM2 Pagina 1 di 40

2 Pathway association and genetic interaction analysis for genome wide association study of cerebrovascular ischemic diseases in the Italian population CARLO BESTA Boncoraglio Giorgio Battista CLI Genes, Genomes and Genetics Genetics of Health and Disease GHD Iron in cholangiocarcinoma: from understanding the role to possible development of novel treatments HUMANITAS Bernuzzi Francesca Oncology 1 Basic Tumor Cell Biology TCB Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy Emilia Romagna Dei Cas Alessandra Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD Molecular determinants of tumour resistance to radio/chemotherapies Veneto Agostini Marco Oncology 2 Oncology 2 Small Business [SBIR/STTR] Radiation Therapy and Biology SETA] Effects of cognitive and aerobic training on cognitive performances and the resting state brain activity in aging individuals Abruzzo Sestieri Carlo Biobehavioral and Behavioral Processes Cognition and Perception CP The role of macrophages in Primary Biliary Cirrhosis: novel targets for immune intervention HUMANITAS Lleo Ana Immunology Hypersensitivity, Autoimmune, and Immune Understanding and treating impairment in automatic movements execution in Parkinson's disease IRCCS AOU San Martino IST (Genova) Marinelli Lucio CLI Integrative, Functional, and Cognitive Cognitive COG Identification of new genetic variations involved in Bipolar I disorder via all exome sequencing of families with high genetic vulnerability from a founder Sardinian population FATEBENEFRATELLI Ducci Francesca Genes, Genomes and Genetics Genetics of Health and Disease GHD Biotherapy of Colorectal Carcinoma by enhancing HLAclass II expression and cooperation with CD16+ myeloid cells in the CRC microenvironment Lazio sileri pierpaolo Oncology 2 Cancer Biomarkers CBSS Pagina 2 di 40

3 The role of internal models in locomotor schemas and neurorehabilitation of children with cerebral palsy SANTA LUCIA Iosa Marco Brain Disorders and Developmental Brain Disorders DBD Cancer stem cells as a model of carcinogenesis for head and neck squamous cell carcinoma: new technologies with potential to translate from the laboratory into the clinic. CROB Sartini Davide Oncology 2 Developmental Therapeutics DT MicroRNA as predictive biomarkers in Hepatoblastoma pediatric tumour Istituto Superiore di Sanita' Salvatore Marco Oncology 1 Basic Cancer Molecular Pathobiology CAMP Novel strategies for tackling obesity epidemics by targeting the resting energy expenditure (EE) AUXOLOGICO Bonomi Marco CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes IPOD Risk assessment and safety procedures for MRI examination on patients with deep brain stimulators Istituto Superiore di Sanita' Mattei Eugenio Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging MEDI NEUROREHABILITATIVE PROGRAM FOR LIMB APRAXIA BY NEUROMODULATION OF LINGUISTIC VICARIOUS SKILLS FATEBENEFRATELLI Sozzi Matteo Integrative, Functional, and Cognitive Cognitive COG HUNT FOR NEW DISEASE GENES IN CONGENITAL MUSCULAR DYSTROPHY WITH HYPOGLYCOSYLATED ALPHA DYSTROGLYCAN STELLA MARIS Cassandrini Denise Alessand Brain Disorders and and NAD dependent signaling as a target in cerebrovascular disease: a preclinical assessment in mouse disease models IRCCS AOU San Martino IST (Genova) Nencioni Alessio Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Congenital Myopathies: genetic screening starting from a new diagnostic algorithm OSPEDALE BAMBINO GESU' D'AMICO ADELE CLI Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD MacroH2A1 in the pathogenesis of metabolic syndromeassociated hepatocellular carcinoma CASA SOLLIEVO SOFFERENZA Pazienza Valerio Oncology 1 Basic Cancer Molecular Pathobiology CAMP Pagina 3 di 40

4 Long term safety and efficacy of thalidomide in IBD. BURLO GAROFALO Lazzerini Marzia CLI Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Autoimmunity in Diabetes: a Holistic Hypothesis of the Diabetes Syndrome SAN DONATO CODELLA ROBERTO Immunology Cellular and Molecular Immunology A CMIA Multimodality MR imaging (DTI, fmri and quantitative relaxometry) for the evaluation of cerebral modifications induced by different rehabilitation protocols in children with cerebral palsy and traumatic brain injury. MEDEA ARRIGONI FILIPPO SILVIO CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE A novel in vivo model to study molecular determinants in lymphopoietic disorders C.R.O. AVIANO Berton Stefania Oncology 1 Basic Tumor Cell Biology TCB Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine SAN MATTEO Lilleri Daniele Immunology Vaccines Against Microbial Diseases VMD INTERMED Self Assessment Study (IMSAS) Selfassessed clinical evaluation of bio psycho social complexity Emilia Romagna Ferrari Silvia CLI Healthcare Delivery and Methodologies Health Services Organization and Delivery HSOD DO INHIBITORY NETWORKS SUSTAIN SEIZURE GENESIS IN FOCAL EPILEPSY? CARLO BESTA Uva Laura Maria Brain Disorders and Acute Neural Injury and Epilepsy ANIE High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices Calabria Perozziello Gerardo Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD The role of T cells in postmenopausal bone loss: focus on autoreactive T cells in peripheral blood of patients affected by severe form of osteoporosis. Piemonte D'AMELIO PATRIZIA Immunology Hypersensitivity, Autoimmune, and Immune Identification of mirnas involved in the regulation of ALK expression in neuroblastoma IRCCS AOU San Martino IST (Genova) Longo Luca Oncology 1 Basic Molecular Oncogenesis MONC Pagina 4 di 40

5 Mitochondria involvement in synaptic dysfunction during early stage of Alzheimer's disease SANTA LUCIA D'Amelio Marcello CLI Brain Disorders and Cell Death in CDIN Neural response to behavioral treatments in Focal Hand Dystonia Veneto Fiorio Mirta CLI Brain Disorders and and PHENOTYPE VARIABILITY IN PRNP E200K MUTATION CARRIERS: A CLINICAL, GENETIC AND PROTEOMIC STUDY Istituto Superiore di Sanita' Poleggi Anna Genes, Genomes and Genetics Genetics of Health and Disease GHD The role of B cells in Graft versus Host Disease after allogeneic hemopoietic cell transplantation Provincia autonoma Bolzano Deola Sara Immunology Transplantation, Tolerance and Tumor Immunology TTT Evaluation of chemotherapy induced liver damage in patients with colorectal liver metastasis using of non invasive tools REGINA ELENA Scarinci Andrea CLI Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Impaired VitaminD metabolism in Rheumatoid Arthritis. Implication for disease pathogenesis and treatment. Piemonte Sainaghi Pier Paolo CLI Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Genetic polymorphism and bisphosphonate related osteonecrosis of the jaws: a case control study Emilia Romagna Manfredi Maddalena Genes, Genomes and Genetics Genetics of Health and Disease GHD GENERATION OF PRION PROTEIN BASED COMPOUNDS AS NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE Lombardia Balducci Claudia Brain Disorders and Cell Death in CDIN Synaptic alteration of mglur signaling underlying SHANK3 mutations in intellectual disability and their rescue by pharmacological therapies CARLO BESTA Verpelli Chiara Molecular, Cellular, and Developmental Molecular Neuropharmacology and Signaling MNPS Pagina 5 di 40

6 Gaining new insights into the molecular mechanisms underlying the cholangiocarcinoma REGINA ELENA Di Filippo Simona Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Engineering the microenvironment of implantable matrices to enhance the host response to tissue damages: a new regenerative medicine approach for wound healing IRCCS AOU San Martino IST (Genova) Tasso Roberta Cell Biology Cellular Signaling and Regulatory Systems CSRS Molecular tools for the diagnosis and treatment of early placentation defects and related pregnancy pathologies BURLO GAROFALO Agostinis Chiara Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Development of minimally invasive techniques in treatment of skull base tumors. Anatomic and clinical study. Lazio Lenzi Jacopo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Acid Retinoic Producing Dendritic Cells as New Therapy for Type 1 Diabetes Sicilia Di Caro Valentina Immunology Hypersensitivity, Autoimmune, and Immune Role of hypoxia induced mir 210 in tissue response to peripheral ischemia ISTITUTO DERMOPATICO DELL'IMMACOLATA Fasanaro Pasquale Vascular and Hematology Vascular Cell and Molecular Biology VCMB A defect in TLR7 gene expression impaires innate and adaptive immunity in Multiple Sclerosis patients: intracellular mechanisms as therapeutic targets Istituto Superiore di Sanita' Severa Martina Immunology Hypersensitivity, Autoimmune, and Immune Oncolytic HSV vector strategy for the study of TRIM8 role in the pathogenesis of glioblastoma and therapy. CASA SOLLIEVO SOFFERENZA Micale Lucia Oncology 1 Basic Cancer Molecular Pathobiology CAMP and biological markers in unipolar vs bipolar depression FATEBENEFRATELLI Nivoli Alessandra Matil Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Role of type I IFN in dictating the immunogenicity of chemotherapy and in predicting the therapeutic efficacy of anticancer treatments Istituto Superiore di Sanita' Bracci Laura Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 6 di 40

7 Autoantibodies specific to ATP synthase in the pathogenesis of Alzheimer disease SAN RAFFAELE PISANA Colasanti Tania Brain Disorders and and Synergistic anticancer effects of the ibraf, imek1/2 and ipi3k in melanoma and possible strategies to overcome the drug resistance PASCALE Capone Mariaelena Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Prospective, Randomized, Multi Center Trial of Lateral Trendelenburg versus Semi Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator Associated Pneumonia MAGGIORE Panigada Mauro CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Circuitry rearrangement and clinical outcome of high technological platform based restorative therapy in an ovine model of stroke: definition of microenvironment interactions and epigenetic modification contribution CARLO BESTA Marfia Giovanni Brain Disorders and Brain Injury and Neurovascular Pathologies BINP mtor dependent oscillatory metabolic switch controlling self immune tolerance SANTA LUCIA De Rosa Veronica Immunology Transplantation, Tolerance and Tumor Immunology TTT Evaluation of effect of PARP inhibitors with or without irradiation in preclinical models of soft tissue sarcomas. Toscana Mangoni Monica Oncology 2 Radiation Therapeutics and Biology RTB Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow up FATEBENEFRATELLI Lougaris Vassilios Immunology Hypersensitivity, Autoimmune, and Immune EARLY EVENTS IN THE INDIRECT PATHWAY IN ANIMAL MODELS OF PARKINSON S DISEASE. NEUROMED Biagioni Francesca Brain Disorders and and Pagina 7 di 40

8 Vaccine platform for oncogenic viruses. PASCALE Tagliamonte Maria Immunology Vaccines Against Microbial Diseases VMD Investigations on the multifaceted role of Enhancer of Zeste 2 (EZH2) in glioblastoma biology CARLO BESTA PELLEGATTA SERENA Oncology 1 Basic Tumor Microenvironment TME Tailoring electrical parameters of subthalamic nucleus stimulation to treat behavioural symptoms in Parkinson s disease MAGGIORE GIANNICOLA GAIA CLI Brain Disorders and and Transcranial Direct Current Stimulation as treatment in depressive illness: mechanism of action and efficacy MAGGIORE FERRUCCI ROBERTA CLI Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS Deregulation of molecular cross talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment. CASA SOLLIEVO SOFFERENZA Muscarella Lucia Anna Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT LONGITUDINAL CHANGES IN MICROARCHITECTURE AND NEURONAL METABOLISM ASSOCIATED WITH PROPRIOCEPTIVE TRAINING TO AMELIORATE BALANCE IN MULTIPLE SCLEROSIS REGINA ELENA Prosperini Luca CLI Emerging Technologies and Training in s Brain Disorders and Related s Fellowship F Role of FOXP3 in breast cancer metastatic process and possible therapeutic targeting ISTITUTO TUMORI MILANO Triulzi Tiziana Oncology 1 Basic Tumor Progression and Metastasis TPM Genetic and functional analysis of circulating micrornas in multiple sclerosis: potential prognostic biomarkers of disease course? MAGGIORE Fenoglio Chiara Brain Disorders and Neuroimmunology and Brain Tumors CNBT Diabetes and neurocognition: the role of glycemic control and vascular comorbidities in elderly people with diabetes NEUROLESI Marino Silvia CLI Biology of Development and Aging Aging Systems and Geriatrics ASG Pagina 8 di 40

9 Modularity for sensory motor control: implications of muscles synergies in motor recovery after stroke. S.CAMILLO Turolla Andrea CLI Biobehavioral and Behavioral Processes Motor Function, Speech and Rehabilitation MFSR Gene Expression Profiles of the aneurysm wall and Genome wide screen in patients with Ruptured and Unruptured Intracranial Aneurysm: are there genetic determinants identifying Ruptured Aneurysm and patients at risk of rupture in Aneurysm Population? CARLO BESTA Acerbi Francesco Vascular and Hematology Vascular Biology Special Emphasis Panel SEVB NEW GENETIC LESIONS CHARACTERIZING HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS Piemonte Rossi Davide Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Targeting neuroprotective endogenous neural stem cells in stroke SANTA LUCIA Nisticò Robert Giovanni CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP MICROBEAM STEREOTACTIC RADIOSURGICAL SUBTHALAMOTOMY AS A NEW SYMPTOMATIC TREATMENT FOR PARKINSON S DISEASE NEUROMED Busceti Carla Letizia Brain Disorders and Cell Death in CDIN New specific calcium inhibitor BZ194 as potential modulator of Myasthenia Gravis CARLO BESTA CORDIGLIERI CHIARA Brain Disorders and Neuroimmunology and Brain Tumors CNBT Cerebrospinal fluid and serum biomarkers of brain damage in epilepsy NEUROLESI Italiano Domenico CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE SiPIMIS (Single Portal with Intraperitoneal Magnetic Instruments Surgery): a brand new no scar surgical approach for major abdominal intervention. Lombardia Zonta Sandro Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Enteric glial cells: at the crossroads of obesity, gastrointestinal neurodysfunction and gut bacterial endotoxins MEDEA Brun Paola Digestive, Kidney and Urological Systems, Integrative and Molecular Gastroenterology CIMG Pagina 9 di 40

10 Assessment of the diagnostic value of novel salivary and lachrymal biomarkers for the early non invasive diagnosis of primary Sjögren s syndrome Toscana Baldini Chiara Musculoskeletal, Oral and Skin Sciences Oral, Dental and Craniofacial Sciences ODCS Diffusion Weighted Imaging (DWI) for the detection and monitoring of pulmonary inflammation: preliminary assessment and validation with molecular imaging. Veneto Morana Giovanni Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering and Imaging Fellowship F Exploring the role of Epstein Barr virus infection and innate immune signalling pathways in the pathogenesis of myasthenia gravis CARLO BESTA Cavalcante Paola Brain Disorders and Neuroimmunology and Brain Tumors CNBT Autoimmunity to PDGF receptor and DNA instability: a novel pathogenic mechanism with implications for new diagnostic and therapeutic tools in fibrotic diseases Marche Moroncini Gianluca Immunology Hypersensitivity, Autoimmune, and Immune In vivo imaging of microglia signature: from mouse models to brain injured patients MAGGIORE Ortolano Fabrizio Molecular, Cellular, and Developmental Cellular and Molecular Biology of Glia CMBG Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer. Toscana Erba Paola Anna CLI Oncology 2 Oncology CONC New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids SAN MATTEO allegri massimo CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Effects of Antidepressant Drugs on Autophagy pathway in neurons MONDINO Russo Rossella Brain Disorders and and Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach. MAGGIORE Vadalà Gianluca Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE Pagina 10 di 40

11 Group I metabotropic glutamate receptors and regulation of synaptic plasticity in a mouse model of Angelman syndrome NEUROMED Molinaro Gemma Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Study of the role of epigenetics in the regulation of microrna expression in heart failure to identify novel therapeutic targets HUMANITAS Papait Roberto Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF The VERY SHINING (Vessels, Endothelium and Risk in the next Years. Sodium Handling and INtake: INteractions with Genes) Study. Veneto Tikhonoff Valerie CLI Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Dual ErbB 3 and PI3K/AKT pathway inhibition as a novel approach to targeting cancer Abruzzo Sala Gianluca Oncology 2 Developmental Therapeutics DT Robotic Therapy for balance recovery and evaluation in pediatrics OSPEDALE BAMBINO GESU' patane fabrizio Integrative, Functional, and Cognitive Sensorimotor Integration SMI The role of enos in neoplastic progression induced by chronic stress. PASCALE Barbieri Antonio Oncology 1 Basic Tumor Microenvironment TME Integration of high throughput and analytical data to discover biomarkers of cell products quality and therapy efficacy in dendritic cells based cancer immunotherapy studies Istituto Superiore di Sanita' Aricò Eleonora Oncology 2 Cancer Biomarkers CBSS Identification of predictive biomarkers of pegifn alphainduced depression and comprehension of the underlying mechanisms FATEBENEFRATELLI Cattaneo Annamaria Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Circulating micrornas as biomarkers of Atrial Fibrillation MONZINO Casella Michela CLI Cardiovascular and Respiratory Sciences Electrical Signaling, Ion Transport, and Arrhythmias ESTA Pagina 11 di 40

12 Loss related pain as reflected by cortical responses to nociceptive stimuli in healthy subjects and individuals with complicated grief: perception, electrophysiology and a tentative pharmacological approach SANTA LUCIA Valentini Elia Integrative, Functional, and Cognitive Cognitive COG Collaboratory and remote mentoring: a strategy to optimize pancreatic islet isolation. Sicilia Casu Anna Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Neuroinflammation in cerebral ischemia: discerning the role of G protein beta/gamma complex translocation in reactive gliosis Sicilia Chisari Mariangela Molecular, Cellular, and Developmental Cellular and Molecular Biology of Glia CMBG Integration of expression profiles and genetic mapping data to identify risk variants in IgA nephropathy Puglia COX SHARON NATA Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney CMBK Empowering the brain. Induction of Hebbian like plasticity in cortico cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients Lazio Avenanti Alessio Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Quantitative gait analysis in older adults with Alzheimer s disease and mild cognitive impairment: pathophysiological meaning and possible clinical applications Toscana Mossello Enrico CLI Brain Disorders and and Neurophysiological indices of functional network integration in vegetative and minimally conscious patients and their relation to awareness and prognosis SANTA LUCIA Astolfi Laura CLI Brain Disorders and and Chimeric antigen receptor redirected T cells targeting CD19 for therapy of high risk/relapsed childhood acute lymphoblastic leukemia OSPEDALE BAMBINO GESU' Pagliara Daria Oncology 2 Cancer Immunopathology and Immunotherapy CII Nanometer size Gold Clusters Bioconjugates for Efficient Drug Delivery C.R.O. AVIANO Rizzolio Flavio Oncology 2 Developmental Therapeutics DT Pagina 12 di 40

13 ELBA.PSDEcological Language Behaviour Assessment For Post Stroke Dementia S.CAMILLO Franco Ludovico CLI Biobehavioral and Behavioral Processes Language and Communication LCOM Involvement of micrornas in triple negative breast cancer: from biology to possible therapeutic applications. ISTITUTO TUMORI MILANO Iorio Marilena Oncology 1 Basic Tumor Cell Biology TCB Structure, Function and New Insight Strategies for Prevention of Left Atrium Remodeling In Mouse Heart Failure MONZINO COLAZZO FRANCESCA Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF Linguistic competence screening for dementia in patients with ischemic stroke. S.CAMILLO Zampieri Elisa CLI Biobehavioral and Behavioral Processes Language and Communication LCOM Extracellular iron as a key signal in muscle necrosis and regeneration SAN RAFFAELE MONTE TABOR Gianfranca Corna Immunology Innate Immunity And Inflammation III Indoleamine 2,3 Dioxygenase and Peripheral Tolerance to Exogenous Factor VIII:A Multi Centre Study Umbria Matino Davide Vascular and Hematology Hemostasis and Thrombosis HT Biomarkers of adverse neuropsychological outcomes in pre term newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) and genetics Abruzzo CAULO MASSIMO CLI Brain Disorders and Developmental Brain Disorders DBD Novel multi scale approach to 3d cancer models for the discovery of new therapeutic strategies for bone metastases GALEAZZI Moretti Matteo Giovanni Oncology 1 Basic Tumor Progression and Metastasis TPM Development and preclinical assessment of an innovative endovascular device to occlude prosthetic paravalvular leakage Veneto ANDREA COLLI Bioengineering Sciences and Technologies Instrumentation and Systems Development ISD Pulmonary Valve Implantation using Self expanding Tissue Valve without Cardiopulmonary Bypass: a Controlled Randomised Trial MAGGIORE URICCHIO NICOLA CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 13 di 40

14 Neural correlates of apathy and Executive Dysfunction in Parkinson s disease. NEUROLESI Varanese Sara Brain Disorders and and Unravelling the susceptibility to develop rotator cuff tears and its role onto surgical outcome OSPEDALE BAMBINO GESU' Longo Umile Giuseppe CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO Investigation of B cell function and diversity in patients with SCID X1 following HSCT or gene therapy Toscana Lippi Francesca Immunology Cellular and Molecular Immunology B CMIB Modulation of HIF by new synthetic PHD2 inhibitors for a new and effective treatment of ischemic heart failure SAN DONATO Anastasia Luigi Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism MIM Fragile X Protein in breast cancer progression CASA SOLLIEVO SOFFERENZA Barbano Raffaela Oncology 1 Basic Tumor Progression and Metastasis TPM Sodium channel Nav1.1: the most relevant epilepsy gene. Pathomechanisms and development of novel therapeutic strategies. Lombardia scalmani paolo Molecular, Cellular, and Developmental Neurotransporters, Receptors, Channels and Calcium Signaling NTRC Traditional Chinese Medicine Herbal Drugs as Modulators of Multidrug Resistance in Cancer Cells Toscana Vannacci Alfredo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT "mirna and protein expression profile in Colorectal cancer: analysis of their potential as screening, prognosis and therapeutic response biomarkers and as therapeutic targets?" Piemonte Tarallo Sonia Oncology 2 Cancer Biomarkers CBSS Identification of new genes responsible for Albinism phenotype Lombardia Mauri Lucia Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 14 di 40

15 Daily at home follow up of Parkinson s Disease patients motor performance through robotic and portable devices SAN RAFFAELE PISANA Tombini Mario Brain Disorders and and Scaffold assisted mesenchymal stem cells therapy for cartilage tissue engineering GALEAZZI de Girolamo Laura Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE Pre clinical assessment of innovative treatments against malignancies based on micrornas ISTITUTO DERMOPATICO DELL'IMMACOLATA Russo Giandomenico Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Studies on the functional role and regulation of a restricted signature of micrornas in acute myeloid leukemia REGINA ELENA Rizzo Maria Oncology 1 Basic Molecular Oncogenesis MONC Modulation of FoxO1 antioxidant function to prevent aging related disorders:diabetes and atherosclerosis Abruzzo consoli agostino Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Novel therapeutic approaches to counteract neuronal loss and cognitive decline in an animal model of AD Abruzzo Sensi stefano Brain Disorders and Cell Death in CDIN IN PURSUIT OF NOVEL THERAPEUTIC STRATEGIES FOR NON ALCOHOLIC FATTY LIVER DISEASE: UNDERSTANDING THE ROLE OF LITAF PROTEIN. OSPEDALE BAMBINO GESU' Alisi Anna Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Nanotechnology for the multiplex diagnosis of infectious diseases Istituto Superiore di Sanita' Nisini Roberto Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Innovation, education and treatment of drug abuse with dual diagnosis (INNUENDO) Abruzzo rossi alessandro CLI Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA Pagina 15 di 40

16 RELEVANCE OF TMEM16A PROTEIN (ANOCTAMIN 1) IN THE PATHOPHYSIOLOGY OF CYSTIC FIBROSIS AND GASTROINTESTINAL MOTILITY DISORDERS GASLINI Galietta Luis Juan Vicent Cell Biology Membrane Biology and Protein Processing MBPP IDENTIFICATION AND VALIDATION OF NEW THERAPEUTIC TARGETS FOR MULTIPLE MYELOMA PATIENTS Emilia Romagna Giuliani Nicola Oncology 1 Basic Molecular Oncogenesis MONC EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF DIFFERENT MEMORY TESTS FOR ALZHEIMER S DISEASE SAN RAFFAELE MONTE TABOR CAPPA Stefano CLI Brain Disorders and and Development of new peptide mimetic compounds and small organic molecules targeting the ErbB3/p85 interaction to improve ErbB2 overexpressing metastatic breast cancers therapy REGINA ELENA Falcioni Rita Oncology 1 Basic Tumor Progression and Metastasis TPM Adjuvant therapy for resected stage III N1 melanoma patients Istituto Superiore di Sanita' Minutilli Ettore CLI Oncology 2 Cancer Immunopathology and Immunotherapy CII Role of Human Papilloma Virus in Head and Neck Cancer. I.E.O. Chiocca Susanna Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB PREGNANCIES IN WOMEN WITH PREVIOUS ADVERSE OBSTETRIC EVENTS AND PREGNANCY RELATED VENOUS THROMBOEMBOLISM : NEW DIAGNOSTIC TOOLS AND IMPROVEMENT OF THERAPEUTHIC STRATEGIES CASA SOLLIEVO SOFFERENZA Chinni Elena Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology PN Assessing the immunomodulatory effect of probiotics in the Experimental Model of Myasthenia Gravis CARLO BESTA Baggi Fulvio Brain Disorders and Neuroimmunology and Brain Tumors CNBT Pagina 16 di 40

17 Correction of Beta Haemoglobinopathies after in situ gene transfer by homologous recombination Liguria FORNI GIANLUCA Genes, Genomes and Genetics Gene Therapy and Inborn Errors GTIE Special Emphasis Panel Turning expression into advantage: a new tool for regulatory T cell therapy BURLO GAROFALO Gasparini Chiara Immunology Transplantation, Tolerance and Tumor Immunology TTT Genomic and Proteomic Biomarkers in Patients with Subarachnoid Hemorrhage Sicilia Germano' Antonino Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Development of vaccines to control salmonellosis using attenuated strains with altered metal uptake capability Istituto Superiore di Sanita' Pasquali Paolo Veterinary Animal Health ANHE Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome GASLINI Varesio Luigi Oncology 1 Basic Tumor Progression and Metastasis TPM Cancer and Heart study: Cancer from Radiological medical imaging in cardiovascular patients Toscana Caramella Davide CLI Cardiovascular and Respiratory Sciences and Integrative Cardiovascular Sciences CICS A web based intervention to educate patients with type 2 diabetes to healthy lifestyles Emilia Romagna Marchesini Reg Giulio CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Autophagy in the immune response against Mycobacterium tuberculosis: identification of novel rapamycin regulated host targets to improve BCG vaccine immunogenicity. Istituto Superiore di Sanita' Coccia Eliana M Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP TArgeted Multistage vector (MSV) for the DIagnosis and treatment of Solid tumors Veneto Nitti Donato Bioengineering Sciences and Technologies Nanotechnology NANO TLR2 at the crossroads between infections and Multiple Sclerosis in human and experimental pathology Lazio Ria Francesco Immunology Hypersensitivity, Autoimmune, and Immune Pagina 17 di 40

18 Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease IRCCS AOU San Martino IST (Genova) Odetti Patrizio Molecular, Cellular, and Developmental Cellular and Molecular Biology of CMND Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs. Emilia Romagna Grilli Roberto CLI Healthcare Delivery and Methodologies Health Services Organization and Delivery HSOD Development of Training Optimization Techniques for Robot assisted Neurorehabilitation. MAUGERI Colombo Roberto Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Noncoding RNAs and cancer IRCCS AOU San Martino IST (Genova) Gherzi Roberto Oncology 1 Basic Molecular Oncogenesis MONC Identification and functional validation of microrna biomarkers in lung cancer ISTITUTO TUMORI MILANO Sozzi Gabriella Oncology 2 Cancer Biomarkers CBSS RAPAMYCIN PLUS DPPIV INHIBITOR IN IMPROVING BETA CELL FUNCTION IN LONG STANDING TYPE 1 DIABETES: PROSPECTIVE RANDOMIZED TRIAL SAN RAFFAELE MONTE TABOR Piemonti Lorenzo Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Molecular and metabolic signature of Gleason grading in prostate cancer Emilia Romagna FIORENTINO MICHELANGEL Oncology 1 Basic Cancer Molecular Pathobiology CAMP HEREDITARY EARLY ONSET ATAXIAS: DIAGNOSTIC PROTOCOLS AND THERAPEUTIC STRATEGIES OSPEDALE BAMBINO GESU' Bertini Enrico CLI Brain Disorders and and Lysophosphatidic acid (LPA) as a lipid modulator of tumor/stroma cross talk during HCC tumor progression ONCOLOGICO DI BARI Giannelli Gianluigi Oncology 1 Basic Tumor Microenvironment TME ECHOCARDIOGRAPHIC EPICARDIAL FAT THICKNESS AS NEW PREDICTIVE MARKER OF CARDIOVASCULAR EVENTS AND CARDIAC REMODELLING SAN DONATO Malavazos Alexis Elias CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Pagina 18 di 40

19 Molecular genetic variants and circulating levels of natriuretic peptides: assessment of their predictive role for cardiovascular acute events and cardiovascular diseases in a general Italian population NEUROMED RUBATTU SPERANZA CLI Cardiovascular and Respiratory Sciences and Integrative Cardiovascular Sciences CICS Wilson disease: methionine metabolism and epigenetic regulation of gene expression Veneto STURNIOLO GIACOMO CAR Genes, Genomes and Genetics Genetics of Health and Disease GHD Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high through put innovative approaches. GASLINI Ghiggeri Gian Marco Digestive, Kidney and Urological Systems Urologic and Kidney Development and Genitourinary Diseases UKGD Exploiting endoplasmic reticulum aminopeptidases modulation for innovative strategies of anticancer immunotherapy OSPEDALE BAMBINO GESU' Fruci Doriana Immunology Transplantation, Tolerance and Tumor Immunology TTT Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV 1 infection and reactivation from latency Interleukin 27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg / mice with human immune system Istituto Superiore di Sanita' Battistini Angela AIDS and Related Research AIDS Immunology and Pathogenesis AIP GASLINI Airoldi Irma Immunology Transplantation, Tolerance and Tumor Immunology TTT THE GASTRIC SUBMUCOSAL SPACE(GSMS) AS A SITE FOR ISLET ALLOTRANSPLANTATION WITH THE USE OF ALEMTUZUMAB Sicilia Veroux Massimiliano Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) ADVANCED THERAPY IN THE TREATMENT OF SKIN LOSS: HUMAN ALLODERMIS WITH PLATELET GEL AND MINIMALLY MANIPULATED MESENCHIMAL STEM CELLS. Toscana FIMIANI MICHELE CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Pagina 19 di 40

20 Reactive oxygen species (ROS) and phosphoinositide 3 kinase (PI3K) signalling in breast cancer Abruzzo Favaloro Bartolo Oncology 1 Basic Tumor Cell Biology TCB New insigths in the treatment of necrotizing enterocolitis: Modulation of the cholinergic antiinflammatory pathway with the use of melanocortins in an experimental neonatal model. Sicilia Romeo Carmelo Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma SAT Brain heart axis impairment in stroke patients: integration of neuroimaging data with cardiovascular variability signals. Istituto Superiore di Sanita' Calcagnini Giovanni Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Characterization and functions of ROR{gamma}t+ IL22 producing innate lymphoid cells in autoimmune and neoplastic human diseases Sicilia Ferlazzo Guido Immunology Innate Immunity And Inflammation III Role of Ezh2 in DNA damage response REGINA ELENA fanciulli maurizio Oncology 1 Basic Tumor Cell Biology TCB Analysis of pattern recognition receptor activation in cognitively impaired subjects SANTA LUCIA Bossu' Paola Brain Disorders and Neuroimmunology and Brain Tumors CNBT Role of purinergic receptor P2X7R in ischemic tissue damage and collateral vessels development SAN RAFFAELE PISANA LA SALA ANDREA Cardiovascular and Respiratory Sciences Cardiovascular Differentiation and Development CDD IDENTIFICATION OF NEW DISEASE GENES IN MITOCHONDRIAL COMPLEX I DEFICIENCY OSPEDALE BAMBINO GESU' Carrozzo Rosalba Brain Disorders and Cell Death in CDIN A novel in vivo diagnostic test for Creutzfeldt Jakob disease (CJD) patients by nasal brushing Istituto Superiore di Sanita' Pocchiari Maurizio Brain Disorders and and Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO Baldassarre Gustavo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 20 di 40

21 Hereditary spastic paraplegia: generation of cellular and animal models to dissect the complex interplay of the pathways involved combined with novel tools for disease diagnosis MEDEA Bassi Maria Teresa Brain Disorders and and Pemphigus vulgaris as a paradigm of autoantibodymediated organ specific autoimmune disorder: pathophysiology and novel tools for diagnosis and therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA Zambruno Giovanna Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS SURVEILLANCE OF MULTI DRUG RESISTANT (MDR) MICRO ORGANISM AND FUNGI COLONIZATION AND INFECTIONS ACQUIRED IN A NOSOCOMIAL SETTING, WITH PARTICULAR REFERENCE TO SURGICAL INFECTIONS IN CANCER PATIENTS AND EMERGENCY SURGERY PATIENTS. Sicilia Di Carlo Paola CLI Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions RPIA Targeting myeloid cells with novel nanotechnology based platforms to control metastatic disease Veneto Bronte Vincenzo Oncology 1 Basic Tumor Progression and Metastasis TPM PROTECTIVE AND DANGEROUS IMMUNE RESPONSES DURING HIV 1 INFECTION OSPEDALE BAMBINO GESU' Rossi Paolo CLI AIDS and Related Research AIDS Immunology and Pathogenesis AIP Study and application of innovative instrumentation and diagnostic protocols in the clinical electrophysiology of vision Istituto Superiore di Sanita' Fadda Antonello Emerging Technologies and Training in s Neurotechnology NT Production and optimization of cartilage and bone spherules for repairing large bone losses and osteoarthritis. Istituto Superiore di Sanita' Valtieri Mauro Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration SBSR Recruitment, computer assisted electroencephalographic analysis and functional evaluation in Encephalopathy with Status Epilepticus during Sleep/Continuous Spike and Waves during Sleep. MONDINO Veggiotti Pierangelo CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Pagina 21 di 40

22 Role of Th22 lymphocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA Cavani Andrea Immunology Cellular and Molecular Immunology A CMIA Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine Istituto Superiore di Sanita' Pajalunga Deborah Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering MTE Gene identification in muscle disorders disrupting cellextracellular matrix interactions CARLO BESTA Mora Marina Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP A toxicological redox assay as a new tool for the discovery of susceptibility biomarkers in Parkinson s disease MONDINO PACCHETTI CLAUDIO Brain Disorders and and The neurobiology of social behaviour: physiological and pathological processes in mice and humans Istituto Superiore di Sanita' Alleva Enrico Biobehavioral and Behavioral Processes Biobehavioral Regulation, Learning and Ethology BRLE Hexanucleotide repeat expansion in c9orf72 as a bridge between amyotrophic lateral sclerosis and other neurodegenerative diseases. AUXOLOGICO Silani Vincenzo Brain Disorders and and Identification of humoral and cellular biomarkers for cerebro and coronary acute vascular events NEUROMED VOLPE MASSIMO CLI Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS ROLE OF THE DNAM 1/PVR PATHWAY IN THE PATHOGENESIS OF HIV 1 INFECTION OSPEDALE BAMBINO GESU' Doria Margherita AIDS and Related Research AIDS Immunology and Pathogenesis AIP Genetics and molecular biomarkers of Food Allergy Toscana Novembre Elio Massimo Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 22 di 40

23 The KidsInPlaces Initiative: an international partnership for the study of societal resilience and early child development Emilia Romagna NICOLI AUGUSTA CLI Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Improving the diagnostic homogeneity in schizophrenia using cognitive endophenotypes: an integrated genetic, neuroimaging and neurocognitive approach SANTA LUCIA Spalletta Gianfranco CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Using hyperbaric hyperoxigenated transportable machine to preserve liver to be transplanted.a new preservation method evaluated throught an animal model transplantation study. Emilia Romagna Rubbini Michele Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS ULTRA HIGH FIELD(7T)MAGNETIC RESONANCE SYSTEM: NEUROMUSCOLAR APPLICATIONS STELLA MARIS Battini Roberta CLI Brain Disorders and and ROLE OF TGFbeta AND HER 2 PATHWAYS IN THE DEVELOPMENT OF EMT, ENDOCRINE RESISTANCE AND BREAST CANCER PROGRESSION Sicilia Veroux Pierfrancesco Oncology 2 Cancer Biomarkers CBSS ANALYSIS OF PHERIPHERAL BLOOD DENDRITIC CELLS IN ALZHEIMER S DISEASE SANTA LUCIA Ciaramella Antonio Brain Disorders and Neuroimmunology and Brain Tumors CNBT Multimodal MRI in the degenerative brain diseases SANTA LUCIA Sabatini Umberto CLI Brain Disorders and and Lower limb robotic exoskeleton for children with motor impairment OSPEDALE BAMBINO GESU' CASTELLI ENRICO CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences MRS Pagina 23 di 40

24 The role of mineralocorticoid receptor (MR) overactivation in obesity:effects of MR blockade in human and animal models of overfeeding. SAN RAFFAELE PISANA Caprio Massimiliano Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Toxins produced by intestinal bacteria and predisposing genetic variations: a dangerous link for colorectal cancer development? Istituto Superiore di Sanita' Fabbri Alessia Oncology 1 Basic Cancer Etiology CE Role of Notch in regulation of mesenchymal cells from adipose tissue of heart failure patients: consequences for cell therapy MAUGERI RIZZO PAOLA Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF Effects of testosterone supplementation on erythropoiesis: potential therapeutic implications in the anemia of older patients Emilia Romagna maggio marcello CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Endocrinology and Reproduction ICER MicroRNAs as potential diagnostic and therapeutic tools for Multiple Osteochondromas disease RIZZOLI SANGIORGI LUCA Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease SBDD Molecular characterization of the epithelial mesenchimal transition process underlying idiopathic pulmonary fibrosis and lung cancer. SAN MATTEO Luisetti Maurizio Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling LIRR Role of relaxin in bone metastasis Veneto Ferlin Alberto Oncology 1 Basic Tumor Progression and Metastasis TPM Cellular and molecular determinants of mitral valve prolapse MONZINO Parolari Alessandro Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems PPCR Pagina 24 di 40

25 Neurobiological bases of the Impulse Control Disorders: the role of the cerebellum. SANTA LUCIA Leggio Maria CLI Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS EVALUATION OF HUMAN ADIPOSE TISSUE DERIVED STROMAL CELLS FOR THE TREATMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS SAN RAFFAELE PISANA Guadagni Fiorella Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity CADO Wnt/b catenin signaling in melanoma: in vitro and in vivo investigations SAN GALLICANO Bellei Barbara Oncology 1 Basic Molecular Oncogenesis MONC The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth. C.R.O. AVIANO Mongiat Maurizio Oncology 1 Basic Tumor Progression and Metastasis TPM Phenotypic characterization and genomic sequencing in schizophrenia SAN RAFFAELE PISANA frustaci alessandra Genes, Genomes and Genetics Genetics of Health and Disease GHD Adipocyte derived leptin as a new tool to manipulate immune response in Tuberculosis Istituto Superiore di Sanita' Palma Carla Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP Unlocking tumor immune recognition through self HLA E molecules REGINA ELENA Giacomini Patrizio Immunology Transplantation, Tolerance and Tumor Immunology TTT Assessment and management of risk factors for sleep disordered breathing and sleep bruxism in pediatric populations. The role of Orthodontics. Emilia Romagna Macaluso Guido Maria CLI Integrative, Functional, and Cognitive Biological Rhythms and Sleep BRS Experimental and clinical evaluation of the role of obesity and its treatment in determining and treating decompensation in chronic liver disease Emilia Romagna Villa Erica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology HBPP Tuberculosis control among immigrants in Italy: a costeffectiveness assessment. Piemonte Migliore Enrica CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Pagina 25 di 40

26 Role of HIF factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti leukemia therapy SAN RAFFAELE MONTE TABOR Bernardi Rosa Oncology 1 Basic Tumor Microenvironment TME The role of microbial agents in prostate cancer pathogenesis C.R.O. AVIANO Tedeschi Rosamaria Oncology 2 Cancer Biomarkers CBSS Amniotic Fluid Stem Cells (AFSCs): molecular markers of osteogenic differentiation and pre clinical studies of orthopedic and odontoiatric diseases. Abruzzo Stuppia Liborio Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Early detection and treatment of recurrent, chemotherapy resistant ovarian cancer stem cells by CPE peptide complexed superparamagnetic iron oxide nanoparticles (CPE SPIONs) ISTITUTO TUMORI MILANO Odicino Franco Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Use of antisense oligonucleotides to PTPN22 gene variant conjugated to immuno liposomes as a novel therapeutic approach in type 1 diabetes and autoimmune polyendocrine syndrome type 3 variant OSPEDALE BAMBINO GESU' FIERABRACCI ALESSANDRA CLI Immunology Hypersensitivity, Autoimmune, and Immune Hypoxia, necrosis, NF kb activation and proinflammatory genes expression in mesothelioma progression. SAN RAFFAELE PISANA Pucci Bruna Oncology 1 Basic Tumor Progression and Metastasis TPM Exploitation of immunogenic tumor cell death for improved dendritic cell based cancer vaccines C.R.O. AVIANO Dolcetti Riccardo Oncology 2 Cancer Immunopathology and Immunotherapy CII Hormonal implications in the mesothelioma pathogenesis. REGINA ELENA Galati Rossella Oncology 1 Basic Tumor Cell Biology TCB Innovative therapeutic approaches against CD49d driven microenvironmental interactions in chronic lymphocytic leukemia C.R.O. AVIANO Gattei Valter Oncology 1 Basic Tumor Microenvironment TME Pagina 26 di 40

27 Enpowering neuromodulation by individually tuned brain behavior frequency Istituto Superiore di Sanita' Ruspantini Irene Emerging Technologies and Training in s Brain Disorders and Related s Fellowship F ASSESSMENT OF THE PHYSIOPATHOLOGICAL MECHANISMS UNDERLYING GLIAL AND NEURONAL DAMAGE AND EVALUATION OF THE NEUROPROTECTIVE EFFECTS EXERTED BY RECOMBINANT ERYTHROPOIETIN AND OTHER TISSUE PROTECTIVE MEDIATORS. Sicilia GRASSO GIOVANNI CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Nutrient Signaling Pathways and Immune Response in the Sensitization of Neuroblastoma and Breast Cancer to Chemotherapy GASLINI Raffaghello Lizzia Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Effect of Human C Peptide on the Prevention of Diabetic Retinopathy and Nephropathy in a Rat Model of Type 2 Diabetes SAN RAFFAELE MONTE TABOR Zerbini Gianpaolo Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Modulation of pharmacogenomic and pharmacodynamic biomarkers of glucose metabolism by metronomic chemotherapy in cancer and endothelial cells Toscana Bocci Guido Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT DOPAMINERGIC MODULATION OF TONIC GABAA INHBITION: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS FOR ABSENCE SEIZURES NEUROMED Ngomba Teke Richard Brain Disorders and Acute Neural Injury and Epilepsy ANIE Myocardial Toll like receptors in human myocarditis. SAN RAFFAELE PISANA Chimenti Cristina CLI Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF NEURAL BASIS OF FREE WILL AND VOLITIONAL INHIBITION IN PARKINSON S AND PHARMACORESISTANT EPILEPTIC PATIENTS NEUROMED MIRABELLA GIOVANNI CLI Brain Disorders and and Pagina 27 di 40

28 Multimodal optical imaging platform for video rate intraoperative near infrared fluorescence cardiac imaging. Provincia autonoma Trento Graffigna Angelo Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences BTSS Vitiligo as model for autoinflammatory induced degenerative disease. SAN GALLICANO Dell'Anna Maria Lucia CLI Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business SEMO MEDITERRANEAN DIET, PHYTO ESTROGENS AND RECURRENCE OF COLORECTAL ADENOMAS. A MULTICENTER RANDOMIZED CONTROLLED TRIAL. DE BELLIS Misciagna Giovanni Oncology 2 Chemo/Dietary Prevention CDP The hmena alternative splicing program and host immune response in EMT and breast tumor progression REGINA ELENA NISTICO' PAOLA Oncology 1 Basic Tumor Microenvironment TME PRE CLINICAL EVALUATIONS OF CELL THERAPY FOR OSTEOARTHRITIS TREATMENT RIZZOLI LISIGNOLI GINA Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Post partum depression:chronobiology, sleep related risk factors and light therapy Emilia Romagna Cirignotta Fabio CLI Risk, Prevention and Health Behavior Psychosocial Risk and Disease Prevention PRDP Identification of a panel of enteric hepatic biomarkers in children with an elevated risk of cardiovascular disease and type 2 diabetes Toscana Pollini Iva CLI Cardiovascular and Respiratory Sciences and Integrative Cardiovascular Sciences CICS Bioengineering of TAVI Istituto Superiore di Sanita' Daniele Carla Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF Myocardial regeneration and functional recovery of the infarcted heart:role of pericardial fluids SAN RAFFAELE PISANA Limana Federica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism MIM Pagina 28 di 40

29 Role of squamous cell differentiation regulators in lung cancer. SDN Missero Caterina Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ACTS Genomic and proteomic profiling in Traumatic Brain Injury patients. Sicilia Tomasello Francesco Brain Disorders and Acute Neural Injury and Epilepsy ANIE Effect of dopamine treatment on neurocognitive functioning in Parkinson s disease: a fmri study SANTA LUCIA Carlesimo Giovanni Brain Disorders and and Muscle Catabolism Fuels Anabolic Tumor Growth: and Therapeutic Implications GASLINI Minetti Carlo Oncology 1 Basic Cancer Etiology CE and molecular genetic spectrum of Coenzyme Q10 deficiencies: identifications of new phenotypes and genetic variants. Implications for the pathogenesis and therapeutic approach. NEUROLESI Musumeci Olimpia CLI Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases TAG Plasma mirnas as prognostic factors in patients with Chronic Lymphocytic Leukemia (CLL) ARCISPEDALE MERLI FRANCESCO Oncology 2 Cancer Biomarkers CBSS Genetics of cardiovascular disease in patients with type 2 diabetes. An integrated approach, including epidemiology, gene expression profiles and cell biology functional studies CASA SOLLIEVO SOFFERENZA Trischitta Vincenzo Genes, Genomes and Genetics Genetics of Health and Disease GHD EARLY ENVIRONMENTAL RISK FACTORS AND THE RISK OF DEVELOPING ANOREXIA NERVOSA FATEBENEFRATELLI Favaro Angela CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Innovative combinatorial therapeutic strategies to revert resistance to target therapy in NSCLC PASCALE Budillon Alfredo Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Pagina 29 di 40

30 Role of multiple HPV infections in the development of cervical diseases. BURLO GAROFALO Comar Manola CLI Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma Lombardia Vermi William Oncology 1 Basic Tumor Microenvironment TME Host biomarkers in exhalate breath condensate and other accessible body fluids for clinical and incipient tuberculosis detection SAN RAFFAELE MONTE TABOR Cirillo Daniela Maria Infectious Diseases and Microbiology Research and Field Studies of Infectious Diseases CRFS P2X7 receptor/mmp9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression SAN RAFFAELE MONTE TABOR Foglieni Chiara Vascular and Hematology Vascular Biology Special Emphasis Panel SEVB Research Strategies for Treatment of Acute Neurodegenerative Disorders CARLO BESTA Gorio Alfredo Brain Disorders and Acute Neural Injury and Epilepsy ANIE Genetic contribution to acquired Long QT Syndrome in cancer patients receiving Tyrosine Kinase Inhibitors MAUGERI Riccardi Alberto CLI Oncology 2 Oncology CONC HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES: PREVALENCE ANDVIRO IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE IRCCS AOU San Martino IST (Genova) DE MARIA ANDREA Immunology Immunity and Host Defense IHD PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY C.R.O. AVIANO De Marco Luigi Vascular and Hematology Hemostasis and Thrombosis HT Molecular bases of phenotypic heterogeneity of Alzheimer's disease: diagnostic and therapeutic implications CARLO BESTA Di Fede Giuseppe Brain Disorders and and Pagina 30 di 40

31 Induced pluripotent stem cell (ipsc) technology in the study of human genetic diseases of the hematologic system: modelling and correcting the cellular and genetic defect HUMANITAS Vezzoni Paolo Maria Immunology Cellular and Molecular Immunology B CMIB New basic and clinical approaches to improve diagnosis and therapeutics strategies in extreme phenotypes of type 2 diabetic patients Piemonte boccuzzi giuseppe Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Membrane remodeling and its role in malaria parasite infection and pathogenesis Istituto Superiore di Sanita' Ponzi Marta Infectious Diseases and Microbiology Pathogenic Eukaryotes PTHE Search for new genes and new therapies for Neonatal Diabetes Mellitus (NDM) and Hyperinsulinism and Hypoglycemia (HH). OSPEDALE BAMBINO GESU' Barbetti Fabrizio CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Role of HIV 1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies Istituto Superiore di Sanita' Toschi Elena AIDS and Related Research AIDS Associated Opportunistic Infections and Cancer AOIC Optimizing the combined use of electrical stimulation and dopaminergic drugs in temporal and spatial aspects of action neuro rehabilitation Lazio Pazzaglia Mariella CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Identification and validation of mirnas as novel biomarkers and therapeutic targets in diffuse malignant peritoneal mesothelioma ISTITUTO TUMORI MILANO Zaffaroni Nadia Oncology 2 Developmental Therapeutics DT Biocompetent dendrons (BD) vs platelet rich plasma (PRP) finalized to induce angiogenesis and bone regeneration in osteonecrosis. Marche Marinelli Mario Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration SBSR impact of accurate patient specific threedimensional treatment planning in molecular radiotherapy ARCISPEDALE Federica Fioroni Oncology 2 Radiation Therapeutics and Biology RTB Pagina 31 di 40

32 New molecular pathways involved in coronary and carotid atherosclerosis SAN RAFFAELE MONTE TABOR Monti Lucilla D. Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS DEVELOPMENT OF VALIDATED INSTRUMENTS TO ASSESS SPINAL CORD INJURY (SCI) SUBJECTS. SANTA LUCIA Scivoletto Giorgio CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Plasma factors, integrins and modulators of podocyte shape. A new window on focal segmental glomerulosclerosis and its treatment GASLINI Candiano Giovanni Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease PBKD A new approach to diagnosis in muscular diseases CARLO BESTA Bernasconi Pia Genes, Genomes and Genetics Genomics, Computational Biology and Technology GCAT Air pollution, Epigenomic Arterial Signatures, and Post Heart Surgery Risk of Cardiovascular Events MAGGIORE BERTAZZI PIETRO ALBER Genes, Genomes and Genetics Genetics of Health and Disease GHD Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1. Toscana Renieri Alessandra Molecular, Cellular, and Developmental Neurodifferentiation, Plasticity, and Regeneration NDPR LCAT MODULATION TO TREAT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE Lombardia Eberini Ivano Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System AICS POST STROKE DYSPHAGIA:CLINICAL, COGNITIVE AND NEUROANATOMICAL CORRELATES Lazio Lenzi Gian Luigi CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Unveiling the microbial signature of Coeliac Disease SDN Ciacci Carolina Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens HIBP Cognitive changes associated with adjuvant chemotherapy (AC) in breast cancer: a FDG PET study Toscana PUPI ALBERTO CLI Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS Pagina 32 di 40

33 Prediction of targeted therapies for hepatocellular carcinoma through molecular profiling of tumorous and cirrhotic tissue Emilia Romagna Cariani Elisabetta Oncology 2 Cancer Biomarkers CBSS Biochemical markers of brain damage following epileptic seizures in children and correlation with cognitive outcome and quantitative imaging data Toscana Guerrini Renzo CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Predicting recidivism of driving under the influence of alcohol and drug. A genetic, neuropsychological and evoked potential study. Veneto TERRANOVA CLAUDIO Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health MESH Glucocorticoid receptor polymorphisms and Corticosteroid Binding Globulin polymorphisms may modulate the clinical effects of immunosuppressive therapy with corticosteroids in determining the risk of developing diabetes after kidney transplantation. Marche Arnaldi Giorgio CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology MCE Molecular mechanisms underlying metabotropic glutamate (mglu) receptor dysfunction in Fragile X syndrome OASI MARIA S.S. Catania Maria Vincenza Molecular, Cellular, and Developmental Molecular Neuropharmacology and Signaling MNPS Cognitive, physiological and imaging correlates of visual hallucinations in Lewy body dementia: a multimodality functional study S.CAMILLO Cagnin Annachiara CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Antigen presentation defects and immunoevasion during colorectal cancer progression HUMANITAS Laghi Luigi Oncology 2 Cancer Immunopathology and Immunotherapy CII Novel surface and intracellular targets for tailored nanotechnology based drug delivery in colorectal cancer SDN Salvatore Francesco Oncology 1 Basic Molecular Oncogenesis MONC Mechanism of hypertrophy in genetically determined Hypertrophic Cardiomyopathy (HCM) Lombardia Gavazzi Antonello Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure CCHF Pagina 33 di 40

34 Use of saliva as biological matrix for non invasive screening of oral cancer ONCOSAL (ONCOlogical Diagnosis by SALiva) CROB Lo Muzio Lorenzo Oncology 2 Cancer Biomarkers CBSS Susceptibility to heat in cohorts of births, children and elderly: a multi centric study to identify short term effects of heat, effect modifiers and to study long term exposure effects over a ten year period Lazio schifano patrizia Population Sciences and Epidemiology Social Sciences and Population Studies SSPS Role of influenza virus infection in the etiopathogenesis of diabetes Istituto Zooprofilattico Sperimentale delle Venezie Capua Ilaria Infectious Diseases and Microbiology Virology A and B Study Sections VIRA and VIRB The impact of the insulin/igf I pathway in bladder cancer invasion and metastasis Calabria Belfiore Antonino Oncology 1 Basic Tumor Progression and Metastasis TPM Shaping the autoimmune response in the gut: the role of intestinal microbiota in immune regulation of Type 1 Diabetes SAN RAFFAELE MONTE TABOR Falcone Marika Maria ca Immunology Hypersensitivity, Autoimmune, and Immune Autoimmunome driven immunotherapy of Alzheimer's Disease Piemonte COMI CRISTOFORO Brain Disorders and and Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications. Abruzzo Berardi Anna Concetta Oncology 1 Basic Tumor Microenvironment TME Role of the immunological impairment in progression of from MGUS to Multiple Myeloma Sicilia Di Raimondo Francesco Oncology 1 Basic Tumor Microenvironment TME Prevention and Treatment of Hardware Infection Through Titanium Surface Modifications and Improved Wound Healing Through Nanoparticle Delivery Mechanisms. MAUGERI Visai Livia Bioengineering Sciences and Technologies Nanotechnology NANO Pagina 34 di 40

35 Mother delivered infant massage in preterm infants to promote neurodevelopment and bonding: effects on infant sleep and brain maturation STELLA MARIS Guzzetta Andrea CLI Brain Disorders and Developmental Brain Disorders DBD CLINICAL AND GENETIC CHARACTERIZATION OF EARLY COMPLICATIONS IN JUVENILE OBESITY OSPEDALE BAMBINO GESU' Cappa Marco CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences and Integrative Diabetes and Obesity CIDO Identification of new biomarkers in rhabdomyosarcoma: potential targets of novel therapeutic strategies. OSPEDALE BAMBINO GESU' Rota Rossella Oncology 1 Basic Cancer Molecular Pathobiology CAMP ROLE OF REGULATORY T CELLS IN THE PATHOGENESIS AND THERAPY OF PRIMARY MYELOFIBROSIS SAN MATTEO Barosi Giovanni Oncology 2 Cancer Immunopathology and Immunotherapy CII Preparatory, response related, outcome evaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation SANTA LUCIA Doricchi Fabrizio CLI Biobehavioral and Behavioral Processes Cognition and Perception CP Hypertension in high school students: Genetic and Environmental Factors Toscana Bigazzi Roberto CLI Population Sciences and Epidemiology Kidney, Nutrition, Obesity and Diabetes KNOD Effects of ambulatory oxygen on breathlessness, mobility and quality of life in patients with idiopathic pulmonary fibrosis Toscana Sestini Piersante CLI Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling LIRR OVERCOMING TARGETED TREATMENT RESISTANCE IN HUMAN CANCER: NOVEL STRATEGIES TO INHIBIT SURVIVAL AND ESCAPE SIGNALS AND TARGETED DELIVERY OF ANTI CANCER NANOPARTICLES REGINA ELENA Milella Michele Oncology 2 Developmental Therapeutics DT Global and gene specific DNA methylation in maternalinfant pairs, environmental exposures, and subsequent respiratory and neurobehavioral phenotypes in childhood Lazio PORTA DANIELA Genes, Genomes and Genetics Genetics of Health and Disease GHD Pagina 35 di 40

36 DEVELOPMENT OF AN INTEGRATED STATISTICS AND INFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW MARKER TECHNOLOGIES ISTITUTO TUMORI MILANO Biganzoli Elia Mario Oncology 2 Cancer Biomarkers CBSS Targeting mitochondria associated Heat Shock Proteins, autophagy and bioenergetics in human solid tumors MAGGIORE Bosari Silvano Oncology 2 Cancer Biomarkers CBSS Early risk indicators and prevention of dementia following stroke. S.CAMILLO Meneghello Francesca CLI Brain Disorders and and DIALECTICAL BEHAVIOR THERAPY (DBT) VS. HIGH QUALITY OUTPATIENT CARE FOR BORDERLINE PERSONALITY DISORDER. A PRAGMATIC RANDOMIZED TRIAL. Emilia Romagna Sanza Michele CLI Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging APDA High density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo EEG and post surgical outcome evaluation Lombardia Nobili Lino CLI Brain Disorders and Acute Neural Injury and Epilepsy ANIE Studies on antibodies in single chain format against the HPV16 E6, E7 oncoproteins as a novel therapeutic approach for HPV associated lesions. Istituto Superiore di Sanita' Accardi Luisa Oncology 2 Basic Mechanisms of Cancer Therapeutics BMCT Quantitative assessment of spasticity: physiopathology and clinical application SANTA LUCIA Cincotti Febo CLI Biobehavioral and Behavioral Processes Motor Function, Speech and Rehabilitation MFSR Comprehensive analysis for identification of prognostic and predictive epigenetic signature in Renal Cell Carcinoma REGINA ELENA Gallucci Michele Oncology 1 Basic Cancer Genetics CG Corticostriatal alterations in dopamine graft transplanted parkinsonian rats: implications for L DOPA therapy SANTA LUCIA Picconi Barbara Brain Disorders and and Pagina 36 di 40

37 Nanotechnology based approach for induction of immune tolerance Lazio magrini andrea Bioengineering Sciences and Technologies Nanotechnology NANO Effect of long term Physical Activity training on health: epigenetic and OMICs integrated approaches SDN Buono Pasqualina Interdisciplinary Molecular Sciences and Training Fellowship: Genes, Genomes, and Genetics F Study of the interactions between noise and vibration exposure in view of the assessment of synergistic effect on the cochlea Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Marchetti Enrico Risk, Prevention and Health Behavior Psychosocial Development, Risk, and Prevention PDRP Whole exome approach to identify the gene responsible for a novel condition associating severe mental retardation with skeletal dysplasia (SEMD Mental Retardation) ARCISPEDALE Garavelli Livia Genes, Genomes and Genetics Molecular Genetics MGA UNRAVELING MECHANISMS UNDERLYING THE RECOVERY OF WALKING ABILITY IN STROKE SURVIVORS Emilia Romagna BASAGLIA NINO CLI Brain Disorders and Brain Injury and Neurovascular Pathologies BINP Preventing onset of psychosis in high risk youths: identification and treatment MONDINO BALOTTIN UMBERTO CLI Brain Disorders and Pathophysiological Basis of Mental Disorders and Addictions PMDA Controlled Ex Vivo Expansion of Human Mesenchymal Stem Cells Methodologies: A First Step Toward ly Relevant Bone Regeneration RIZZOLI Ciapetti Gabriela Cell Biology Intercellular Interactions ICI Associations between ambulatory blood pressure monitoring profiles, cognitive decline, and diastolic dysfunction in the very elderly population: a multicentre study to identify novel, population specific, management algorithms. AUXOLOGICO Bilo Grzegorz CLI Cardiovascular and Respiratory Sciences and Integrative Cardiovascular Sciences CICS Multi criteria decision approach (MCDA) to analyse priority setting decisions in the context of a transition from acute focused towards chronic care focused healthcare systems: implications for the Italian SSN Emilia Romagna Cencetti Stefano CLI Healthcare Delivery and Methodologies Health Services Organization and Delivery HSOD Pagina 37 di 40

38 Disability related chronic conditions in older adults: an innovative approach to estimate the disease burden and the adherence to evidence based pharmacological treatments using linked clinical and administrative data. Lazio Agabiti Nera CLI Healthcare Delivery and Methodologies Health Services Organization and Delivery HSOD Hormonal changes and impaired spermatogenesis in young males with different levels of spinal cord injury: A longitudinal study MAUGERI Rotondi Mario CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel F Gene identification in rare genetic disorders affecting lysosomal degradation pathways in skeletal muscle. CARLO BESTA Di Blasi Claudia Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology SMEP From personality to molecular mechanisms through neurocognitive phenotypes: a translational study of liability to compulsive drug seeking SANTA LUCIA Cabib Simona Brain Disorders and Neural Basis of Psychopathology, Addictions and Sleep Disorders NPAS THERapeutically relevant STEM cells for THALassemia (THERSTEMTHAL) Emilia Romagna GAMBERINI MARIA RITA Genes, Genomes and Genetics Gene Therapy and Inborn Errors GTIE Special Emphasis Panel Identification of slow proliferating cancer cells with stemlike features Istituto Superiore di Sanita' Molinari Agnese Oncology 1 Basic Cancer Molecular Pathobiology CAMP Preclinical studies on TM9SF4, a novel potential biomarker associated with malignancy in patients with skin cancers Istituto Superiore di Sanita' Lozupone Francesco Oncology 1 Basic Tumor Cell Biology TCB Immunological properties of fetal stem cells retrieved from placenta and amniotic fluid Veneto Giacomello Luca Immunology Transplantation, Tolerance and Tumor Immunology TTT Pagina 38 di 40

39 Validation of a health technology for calculating fractionated doses for pediatric drugs Piemonte Bertino Enrico CLI Healthcare Delivery and Methodologies Biomedical Computing and Health Informatics BCHI Regulation of cancer stem cell symmetric divisions by myc I.E.O. Pelicci Pier Giuseppe Oncology 1 Basic Molecular Oncogenesis MONC Functional validation of candidate oncogenes in pancreatic cancer SAN RAFFAELE MONTE TABOR Doglioni Claudio Oncology 2 Cancer Biomarkers CBSS Control of Feral Dog Populations by Immunocontraception Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Fico Rosario Veterinary Animal Health ANHE Mechanisms of altered DNA methylation in sporadic and hereditary colorectal cancer REGINA ELENA Anti Marcello Genes, Genomes and Genetics Molecular Genetics MGA The early phases of diabetic retinopathy: possible role of Pigmented Epithelium Derived Factor in contrasting neuroglial dysfunction Istituto Superiore di Sanita' Pricci Flavia Cell Biology Biology and Diseases of the Posterior Eye BDPE Study of SP A polymorphisms as a predictor of over all lung transplant outcome. SAN MATTEO Meloni Federica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling LIRR Neurophysiological and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinson s Disease with Dementia NEUROLESI Thomas Astrid Maria Brain Disorders and and Optoelectronic retinal prosthesis: the astrocyte approach to visual restoration. Toscana GIANSANTI FABRIZIO Emerging Technologies and Training in s Neurotechnology NT NOVEL APPROACH FOR BONE REGENERATION AND REPAIR USING SULFUR DONOR BASED THERAPY RIZZOLI Grassi Francesco Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration SBSR Pagina 39 di 40

40 MRI imaging of tumor associated macrophages in the early development of lung and bone metastasis SAN RAFFAELE PISANA Santini Daniele Oncology 2 Cancer Biomarkers CBSS The impact of local sleep on awake human behavior Toscana Pietrini Pietro Integrative, Functional, and Cognitive Biological Rhythms and Sleep BRS TUMORIGENIC CELLS OF PANCREATIC CANCER. IN SITUIDENTIFICATION AND CLINICAL SIGNIFICANCE Lazio Coppola Roberto Interdisciplinary Molecular Sciences and Training Fellowship: Oncological Sciences F FK 506 Pharmacogenetics/Pharmacogenomics and new approaches in FK 506 therapeutic drug monitoring in pediatric and adult liver transplantation Piemonte Calvo Pier Luigi Immunology Transplantation, Tolerance and Tumor Immunology TTT Oxidative stress induced DNA damage response and autophagy in skeletal muscle cells: mechanisms and implication for muscle dystrophy SANTA LUCIA Latella Lucia Biology of Development and Aging Cellular Mechanisms in Aging and Development CMAD Pagina 40 di 40