Ministero della Salute

Transcription

1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA GRADUATORIA PROGETTI ORDINARI Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity MAUGERI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 4, mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Istituto Superiore di Sanita' Oncology 1 Basic 4, Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach Oncology 1 Basic 4, EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread C.R.O. AVIANO Oncology 1 Basic 4, Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA Oncology strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Piemonte Oncology TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING HUMANITAS Oncology 1 Basic Pagina 1 di 142

2 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Molecular, Cellular, and Developmental Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' Immunology Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia SANTA LUCIA Brain Disorders and The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets Istituto Superiore di Sanita' Oncology 1 Basic Gene therapy for thalassemia: preclinical studies of efficacy and safety Genes, Genomes and Genetics Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO Oncology Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration FATEBENEFRATELLI Brain Disorders and 5, Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. Surgical Sciences, Biomedical Imaging, and Bioengineering 5, Thrombolysis in Minor Stroke Emilia Romagna Brain Disorders and 5, Pagina 2 di 142

3 The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V Emilia Romagna Digestive, Kidney and Urological Systems 5, Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia Population Sciences and Epidemiology 5, Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 5, Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 5, NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 5, A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis Digestive, Kidney and Urological Systems 5, Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche Molecular, Cellular, and Developmental 5, IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING GASLINI Genes, Genomes and Genetics 5, Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. MAUGERI Oncology 1 Basic 5, (2) Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Pagina 3 di 142

4 TRANSLATING MELANOMA EPIGENETICS IN THE NICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Toscana Oncology 2 5, RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio Cell Biology IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO Oncology THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES SAN DONATO Population Sciences and Epidemiology Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA Brain Disorders and PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO Cardiovascular and Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA Biobehavioral and Behavioral Processes IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Emilia Romagna Brain Disorders and B7.1 on podocytes: a new therapeutic target for diabetic nephropathy Digestive, Kidney and Urological Systems Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer Calabria Oncology Pagina 4 di 142

5 FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. Genes, Genomes and Genetics Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Toscana Immunology Improving balance through gravity cues embedded in free falling target SANTA LUCIA Biobehavioral and Behavioral Processes Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling Lombardia Brain Disorders and "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. MAGGIORE Digestive, Kidney and Urological Systems Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. PASCALE Oncology 1 Basic Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? S.CAMILLO Brain Disorders and THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING NICAL DISORDERS Vascular and Hematology Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man Population Sciences and Epidemiology Pagina 5 di 142

6 MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio Vascular and Hematology 6, Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana Cardiovascular and 6, The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial FATEBENEFRATELLI Biobehavioral and Behavioral Processes 6, Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Oncology 1 Basic 6, Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy Digestive, Kidney and Urological Systems 6, Genetics of Hearing loss: from basic research to clinical applications BURLO GAROFALO Genes, Genomes and Genetics 6, Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution Brain Disorders and 6, A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Emilia Romagna Digestive, Kidney and Urological Systems 6, CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia Surgical Sciences, Biomedical Imaging, and Bioengineering 6, Novel markers based on autophagy proteins in Parkinson's disease NEUROMED Brain Disorders and 6, Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Piemonte Brain Disorders and 6, Pagina 6 di 142

7 Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Toscana Molecular, Cellular, and Developmental 6, Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6, Regulation of mitotic transitions I.E.O. Cell Biology 6, Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation CARLO BESTA Molecular, Cellular, and Developmental 6, ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria Brain Disorders and 6, Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Brain Disorders and 6, Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a GASLINI Genes, Genomes and Genetics 6, Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases Cell Biology 6, Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Istituto Superiore di Sanita' Brain Disorders and 6, DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO Oncology 2 6, Pagina 7 di 142

8 Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) Biological Chemistry and Macromolecular Biophysics 6, A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. Oncology 2 6, The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment SANTA LUCIA Genes, Genomes and Genetics 6, Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis Musculoskeletal, Oral and Skin Sciences 6, Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 6, Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. SAN RAFFAELE PISANA Brain Disorders and 6, Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. SDN Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6, Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences Reorganization of cortical function after surgery for lesional epilepsy in children Toscana Brain Disorders and GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinson s Disease SAN RAFFAELE PISANA Brain Disorders and Pagina 8 di 142

9 Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia SAN MATTEO Genes, Genomes and Genetics Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Lombardia Cardiovascular and SALUTE CKD (SALt lowering by Urine sodium selfmeasurement Trial in Chronic Kidney DiseasE) Calabria Risk, Prevention and Health Behavior Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Istituto Superiore di Sanita' Infectious Diseases and Microbiology To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics Role of APOBEC1 in the initiation and progression of cancer Toscana Oncology 1 Basic Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA Brain Disorders and Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Cardiovascular and Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development Lombardia Biology of Development and Aging Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) Immunology Pagina 9 di 142

10 Enhanced cell proliferation for muscle repair and regenerative medicine Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences Cytokines as biomarkers of disease and therapeutic targets in laminopathies RIZZOLI Biology of Development and Aging Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA Brain Disorders and A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. PASCALE Oncology PRENICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Istituto Superiore di Sanita' Infectious Diseases and Microbiology Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO Oncology 1 Basic Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Brain Disorders and A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Oncology 1 Basic CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Istituto Superiore di Sanita' AIDS and Related Research Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Oncology Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Oncology 1 Basic Pagina 10 di 142

11 Dysregulated RNA metabolism in multiple myeloma. Oncology 1 Basic Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation Sicilia Infectious Diseases and Microbiology Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA Brain Disorders and Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE Genes, Genomes and Genetics 7, Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multi pathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 7, IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED NICAL PARAMETERS MULTIMEDICA Oncology 2 7, (2) From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA Oncology 1 Basic 7, Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer poly peptide vaccine directed against the thymidylate synthase enzyme. Toscana Oncology 2 7, Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Piemonte Cardiovascular and 7, White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7, Pagina 11 di 142

12 Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cellbased immunotherapy in patients with refractory disease SAN MATTEO Oncology 2 7, Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' Oncology 1 Basic 7, Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia Genes, Genomes and Genetics 7, Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 7, Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Genes, Genomes and Genetics 7, IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS Molecular, Cellular, and Developmental 7, Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI Brain Disorders and 7, CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7, AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA Musculoskeletal, Oral and Skin Sciences 7, Role of novel modulators of ectopic mineralization during aortic valve disease progression Veneto Vascular and Hematology 7, Pagina 12 di 142

13 Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO Oncology 2 7, GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT NICAL IMPLICATIONS SANTA LUCIA Brain Disorders and 7, INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYC DI GMP METABOLISM Lazio Infectious Diseases and Microbiology 7, MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Oncology 1 Basic 7, The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE Oncology 1 Basic 7, Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. SAN RAFFAELE PISANA Brain Disorders and 7, Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 7, Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure AUXOLOGICO Cardiovascular and 7, Electronic health databases as a source of reliable information for effective health policy Puglia Healthcare Delivery and EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE FATEBENEFRATELLI Healthcare Delivery and Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Toscana Cardiovascular and Pagina 13 di 142

14 Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Sicilia Digestive, Kidney and Urological Systems Toward the development of an in vitro test for ALS: largescale validation of PBMC protein biomarkers Lombardia Brain Disorders and Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction BURLO GAROFALO Vascular and Hematology A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' Healthcare Delivery and MiRNAs in Forebrain Neurogenesis Biology of Development and Aging Role of autophagy in growth, progression and vascular mimicry of neuroblastoma GASLINI Oncology 1 Basic MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Oncology 1 Basic Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB Oncology 1 Basic Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) Oncology 1 Basic Development of novel cell products for their clinical use in cancer immunotherapy Istituto Superiore di Sanita' Oncology Pagina 14 di 142

15 MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. REGINA ELENA Oncology 1 Basic Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis Endocrinology, Metabolism, Nutrition and Reproductive Sciences Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation Piemonte Digestive, Kidney and Urological Systems NACHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER REGINA ELENA Oncology Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' Genes, Genomes and Genetics Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Calabria Brain Disorders and Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana Brain Disorders and Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCV associated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 1 Basic Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. MAUGERI Cardiovascular and NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' Infectious Diseases and Microbiology Pagina 15 di 142

16 Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneurons development. Molecular, Cellular, and Developmental Targeting CD99 to treat sarcomas RIZZOLI Oncology Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. Brain Disorders and Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration S.CAMILLO Brain Disorders and Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell permeable peptides in preclinical models MAUGERI Brain Disorders and Kinetochore spindle binding as a new anticancer drug target. I.E.O. Oncology IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS Genes, Genomes and Genetics Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia Cardiovascular and The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Toscana Brain Disorders and Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' Oncology Pagina 16 di 142

17 Optimization of alloreactive natural killer (NK) cell and invariant NKT (inkt) cell mediated anti leukemia effect in children with hematological malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel OSPEDALE BAMBINO GESU' Oncology MSC based therapy for the bone marrow and solid organs transplantations Lombardia Oncology Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Brain Disorders and A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) Piemonte Oncology 1 Basic EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody MONZINO Vascular and Hematology Istituto Superiore di Sanita' Immunology Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia Oncology 1 Basic 8, Pagina 17 di 142

18 THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Toscana Cardiovascular and 8, LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab I. O. V. Oncology 2 8, The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. Oncology 1 Basic 8, Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies Istituto Superiore di Sanita' Infectious Diseases and Microbiology 8, Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano Oncology 2 8, Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. BURLO GAROFALO Digestive, Kidney and Urological Systems 8, An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study ARCISPEDALE Healthcare Delivery and 8, The contribution of ICT to patient safety in surgical process Emilia Romagna Healthcare Delivery and 8, Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio Brain Disorders and 8, Pagina 18 di 142

19 Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 8, Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Emilia Romagna Brain Disorders and 8, MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL Toscana Infectious Diseases and Microbiology 8, Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA Brain Disorders and 8, Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department Toscana Healthcare Delivery and 8, Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. NEUROLESI Brain Disorders and 8, Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms Brain Disorders and 8, Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. Lombardia Brain Disorders and 8, ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA SDN Molecular, Cellular, and Developmental 8, Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients Genes, Genomes and Genetics 8, The use of an innovative microarray platform into the clinical setting Sicilia Genes, Genomes and Genetics 8, Pagina 19 di 142

20 Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Oncology 1 Basic 8, THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA Toscana Oncology 2 8, Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Molecular, Cellular, and Developmental 8, Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Cell Biology 8, DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8, Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 8, MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS MAGGIORE Genes, Genomes and Genetics 8, Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8, Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Emilia Romagna Immunology 8, Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8, Pagina 20 di 142

21 Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. REGINA ELENA Oncology 1 Basic 8, NUTRIGENOMICS IN PEDIATRIC INFLAMMATORY BOWEL DISEASES: A NEW BASIS FOR SERUM MARKERS DISCOVERY Veneto Digestive, Kidney and Urological Systems 8, NICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY:A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' Immunology 8, Development of beta cell specific aptamers as novel diagnostic and therapeutic tools for diabetes mellitus. Surgical Sciences, Biomedical Imaging, and Bioengineering 8, Redox dysfunctions in autoinflammatory syndromes. Role in disease course, novel therapeutic approaches IRCCS AOU San Martino IST (Genova) Immunology 8, Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis HUMANITAS Immunology 8, Paraganglioma syndrome associated with succinate dehydrogenase defects: toward the discovery of biomarkers and novel pharmacological therapies I. O. V. Oncology 1 Basic 8, Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches SAN MATTEO Biological Chemistry and Macromolecular Biophysics 8, Generation of artificial lymphoid organs with mutipotent stromal progenitors derived from induced pluripotent stem cells. Biology of Development and Aging 8, Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms AUXOLOGICO Genes, Genomes and Genetics 8, Purinergic modulation of SDF 1/CXCR4 directed endothelial and cardiac progenitors cell functions: theraupetic potential in cardiovascular regeneration. SAN RAFFAELE PISANA Cardiovascular and 8, Pagina 21 di 142

22 Heterotypic interactions in thrombo inflammatory processes associated with the thrombotic vascular occlusion in sepsis: the role of vitamin K dependent protein C Vascular and Hematology 8, A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. MAGGIORE Brain Disorders and 8, Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Lazio Population Sciences and Epidemiology MODULATING NEUREGULIN 1 SIGNALS TO TREAT HEREDITARY DEMYELINATING NEUROPATHIES Molecular, Cellular, and Developmental Molecular mechanisms of neutrophil recruitment as novel targets to curb lung damage in cystic fibrosis. Abruzzo Cardiovascular and Targeting altered proton dynamics of sarcomas as an effective therapeutic tool RIZZOLI Oncology NEURONAL POTASSIUM CHANNEL KV3.4 AS A NON TRADITIONAL MOLECULAR TARGET FOR THE DEVELOPMENT OF DRUGS PREVENTING NEURONAL CELL DEATH IN ALZHEIMER DISEASE SAN RAFFAELE PISANA Molecular, Cellular, and Developmental Dissecting the CLL lipidome in search for novel prognostic markers and targets for tailored therapy Oncology MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR NICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME HUMANITAS Integrative, Functional, and Cognitive Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments MONDINO Healthcare Delivery and Pagina 22 di 142

23 DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna Healthcare Delivery and IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA Healthcare Delivery and METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER SDN Digestive, Kidney and Urological Systems DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER2+ cancer patients Piemonte Oncology Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche Population Sciences and Epidemiology PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Lombardia Risk, Prevention and Health Behavior Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery SANTA LUCIA Brain Disorders and Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano Healthcare Delivery and The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 23 di 142

24 Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] Lazio Cardiovascular and IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE Emilia Romagna Digestive, Kidney and Urological Systems Exercise and inflammation in obesity. Evaluation of relationships and possible interventions. (ObInEx Project) DON GNOCCHI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer s Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an in vitro model of anesthetic inducing oligomerization NEUROLESI Brain Disorders and CHANGES IN STRUTTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA Integrative, Functional, and Cognitive Assessing the effect of an intensive rehabilitation treatment(irt) on neurotrophic factors production in patients with Parkinson s disease MAUGERI Brain Disorders and Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Cardiovascular and Polymeric films and magnetic forces for gallbladder retraction during a fully translumenal cholecystectomy Piemonte Surgical Sciences, Biomedical Imaging, and Bioengineering HIGH THROUGHPUT TECHNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC MARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) Puglia Digestive, Kidney and Urological Systems Pagina 24 di 142

25 Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary Aberrant choline metabolism in ovarian cancer as a source of multilevel data in prognosis and/or therapeutic guidance. ISTITUTO TUMORI MILANO Oncology Muscle fibrosis in DMD: Molecular characterization with a new human in vitro model and therapeutic approach CARLO BESTA Musculoskeletal, Oral and Skin Sciences Characterizations of the anti Tat adaptative immune responses in individuals naturally controlling HIV 1 replication AIDS and Related Research MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Oncology 1 Basic Genetic characterization of supraventricular arrhythmias by whole exome sequencing Cardiovascular and Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non invasive biomarkers in colon and rectal cancer I. O. V. Oncology Role of trace element in the pathogenesis of Multiple sclerosis Istituto Superiore di Sanita' Population Sciences and Epidemiology Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto Infectious Diseases and Microbiology Defining non invasive outcome measures and elucidating the molecular mechanisms underlying muscle degeneration in Facioscapulohumeral muscular dystrophy DON GNOCCHI Musculoskeletal, Oral and Skin Sciences Role of IBtk, a B cell signalling regulator, in cancer development. Calabria Cell Biology Pagina 25 di 142

26 Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE PISANA Infectious Diseases and Microbiology Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders SANTA LUCIA Integrative, Functional, and Cognitive Revealing brain mechanisms of Chronic Subjective Dizziness SANTA LUCIA Integrative, Functional, and Cognitive Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO Molecular, Cellular, and Developmental Characterization of the genomic architecture of myelodysplastic syndromes and definition of a molecular basis for their classification and prognostication SAN MATTEO Oncology 1 Basic MicroRNAs as molecular biomarkers for early detection of sporadic Fronto temporal Dementias Umbria Brain Disorders and Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment FATEBENEFRATELLI Biobehavioral and Behavioral Processes Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino IST (Genova) Oncology 1 Basic ADVANCED NICAL AND MOLECULAR EFFORTS IN HEREDITARY SPASTIC PARAPLEGIA STELLA MARIS Brain Disorders and Role of Chromatin Remodeling in Epigenetic Cell Memory SANTA LUCIA Genes, Genomes and Genetics Effect of proteasome and VEGF receptor inhibitors on NKG2D ligand expression on hepatocellular carcinoma cells: implications for immunotherapy of liver cancer. SAN MATTEO Oncology THE ROLE OF CALCIUM HOMEOSTASIS IN DEVELOPMENTAL ATAXIAS: genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ ATPase. OSPEDALE BAMBINO GESU' Molecular, Cellular, and Developmental Pagina 26 di 142

27 An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification MONZINO Brain Disorders and Pathogenesis of congenital human cytomegalovirus infection SAN MATTEO Infectious Diseases and Microbiology A combination of surveys, spatial analyses and molecular epidemiology to get an insight of pre harvest risks from Shiga toxin producing Escherichia coli. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice FATEBENEFRATELLI Brain Disorders and Predictive factors of response to therapies in colorectal and breast cancers. MAUGERI Oncology 1 Basic 9, Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease MAUGERI Brain Disorders and 9, Prognostic utility of biological indicators in human colorectal cancer: the chemokine axis CX3CL1/CX3CR1 HUMANITAS Oncology 1 Basic 9, Sirt1 and Sirt2 as targets for the manipulation of the proliferative processes associated to physiopathologic conditions of the skin ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 9, A CORRELATIVE, NEUROIMMUNOVIROLOGICAL AND MRI ANALYSIS OF PROGNOSTIC MARKERS IN ALZHEIMER'S DISEASE DON GNOCCHI Brain Disorders and 9, Understanding and enhancing the therapeutic effect of FTY720 (Fingolimod) in multiple sclerosis: a structural biology approach Biological Chemistry and Macromolecular Biophysics 9, Pagina 27 di 142

28 Circulating tumor cells, with stem like and/or epithelialmesenchymal transition features, detectable in peripheral blood of breast cancer patients: biological and clinical significance ISTITUTO TUMORI MILANO Oncology 2 9, Dominant optic atrophy (DOA) and OPA opathies in Italy: prevalence, phenotypes, genes and functional studies towards a therapy Istituto Scienze Neurologiche Brain Disorders and 9, An integrated genomic and immunologic approach to novel strategies of monitoring and therapy for HBV and HCV infections Emilia Romagna Infectious Diseases and Microbiology 9, Ageing at work: promoting health and safety of ageing workers according to changes of demography, labour market and social policies. MAGGIORE Risk, Prevention and Health Behavior 9, Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto Genes, Genomes and Genetics 9, Whole genome scanning in AML to develop a better prognostic stratification and personalized risk based therapies SAN MATTEO Oncology 2 9, Food irradiation: quality and detection of plant origin food with health benefits Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Veterinary 9, In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9, Molecular biomarkers and cellular biosensors of neurodegeneration Brain Disorders and 9, CENTRAL EFFECTS OF BOTULINUM NEUROTOXINS: THERAPEUTIC IMPLICATIONS Toscana Brain Disorders and 9, Role of Calcium/Calmodulin dependent Kinase Kinase 2 in metabolic stress and inflammatory response SAN RAFFAELE PISANA Immunology 9, Pagina 28 di 142

29 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors. ISTITUTO TUMORI MILANO Oncology 1 Basic 9, Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. OASI MARIA S.S. Interdisciplinary Molecular Sciences and Training 9, Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Toscana Oncology 2 9, Neural Stem Cell mediated Therapy of Amyotrophic Lateral Sclerosis CASA SOLLIEVO SOFFERENZA Brain Disorders and 9, Adverse Health Effects of Airborne Particle Pollution: a multidisciplinary study IRCCS AOU San Martino IST (Genova) Population Sciences and Epidemiology 9, Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Istituto Zooprofilattico Sperimentale della Sardegna Veterinary 9, Strategy of immunotherapy with specific T lymphocytes versus B cell acute lymphoblastic leukemia Piemonte Oncology 2 9, IDENTIFICATION OF PHENOTYPE MODULATOR VARIANTS IN LAMIN A/C MUTATION CARRIERS BY EXOME AND GENOME SEQUENCING Genes, Genomes and Genetics 9, Role of TIR8, a novel member of IL 1R/TLR family with a negative regulatory activity, in inflammation and cancer. HUMANITAS Immunology 9, Epigenetic memory and impairment of human endothelial and mesenchymal progenitor activity by cardiovascular risk factors MONZINO Cardiovascular and 9, Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Toscana Healthcare Delivery and 9, Pagina 29 di 142

30 Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Emilia Romagna Population Sciences and Epidemiology 9, Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Emilia Romagna Oncology 2 9, Telemedicine Services for UTAP Veneto Healthcare Delivery and 9, Screening of children at risk for language and communication disorders Lazio Biobehavioral and Behavioral Processes 9, Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets PASCALE Oncology 2 9, Soluble biomarkers predicting coronary bypass graft patency MONZINO Surgical Sciences, Biomedical Imaging, and Bioengineering 9, EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: NICAL/REHABILITATIVE IMPLICATIONS FOR DISORDERS OF SPATIAL ATTENTION IN STROKE PATIENTS SANTA LUCIA Brain Disorders and 9, Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Friuli Venezia Giulia Healthcare Delivery and 9, Optimization of the clinical management of endocrineresponsive early breast cancer patients IRCCS AOU San Martino IST (Genova) Oncology 2 9, Pathway Dissection In Leukocyte Migration: Identification And Validation Of Novel Therapeutic Targets In Nonresolving Inflammation Immunology 9, Pagina 30 di 142

31 Disease related biomarkers investigation in Multiple sclerosis by analysis of microvesicles isolated by CSF. Sicilia Molecular, Cellular, and Developmental 9, Identification of prognostic and predictive serum biomarkers for monitoring type 1 diabetes risk and progression in humans Toscana Immunology 9, Necdin role in myogenic stem cells self renewal and maintenance for the repair of the dystrophic muscle Musculoskeletal, Oral and Skin Sciences 9, Functional significance of manipulating endogenous neurogenesis for nigrostriatal dopaminergic neuroprotection/neurorepair in murine models of Parkinson s disease: focus on neuroinflammation OASI MARIA S.S. Brain Disorders and 9, A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 9, The key role of serotonin in the pathophysiology of phenylketonuria: from bench to bedside OASI MARIA S.S. Brain Disorders and 9, Oxidative stress and microrna 125b : from molecular mechanisms to therapeutic implications in Hailey Hailey disease Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 9, TISSUE PATCH ENGINEERING OF ADIPOSE DERIVED STEM CELLS FOR MEDICAL DEVICES. MAGGIORE Bioengineering Sciences and Technologies 9, HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9, Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Brain Disorders and 9, DEFINING INNOVATIVE TREATMENT STRATEGIES FOR OSTEOSARCOMA BASED ON THE INHIBITION OF ABC TRANSPORTERS AND PROTEIN KINASES RIZZOLI Oncology 2 9, Pagina 31 di 142

32 Corrected ipsc as therapeutic source for Spinal Muscular Atrophy MAGGIORE Molecular, Cellular, and Developmental 9, THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia Brain Disorders and 9, EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO Healthcare Delivery and 9, Prognostic marker of cytomegalovirus infection and transmission in pregnancy. Emilia Romagna Infectious Diseases and Microbiology 9, ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna Brain Disorders and 9, Vitamin D and Myasthenia Gravis: from the animal model to the human disease CARLO BESTA Brain Disorders and 9, Application of nanomechanical assays to detection of algal toxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 9, A study on molecular characteristics of the gp120 Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Istituto Superiore di Sanita' AIDS and Related Research 9, Efficacy of re treatment with anti TNF biologics in patients with psoriasis who have been previously treated with the same biological drug SAN GALLICANO Musculoskeletal, Oral and Skin Sciences HOME BASED COGNITIVE REHABILITATION AFTER BRAIN DAMAGE THROUGH VIRTUAL REALITY Lombardia Brain Disorders and Pagina 32 di 142

33 MicroRNAs as potential therapeutic strategies to prevent adverse vascular events and increase angiogenesis after limb ischemia. Calabria Cardiovascular and The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson s Disease OASI MARIA S.S. Brain Disorders and EFFECT OF DEACETILASE INHIBITORS ON EPIGENETIC BALANCE OF E CADHERIN: NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Piemonte Oncology 1 Basic Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying inherited thombophilias. A family study CASA SOLLIEVO SOFFERENZA Population Sciences and Epidemiology Aphasia. Theory for therapy. Therapy for theory. S.CAMILLO Brain Disorders and The modulation of T helper cell death as therapeutic approach to reduce the pathogenic cells in Multiple Sclerosis (MS). SANTA LUCIA Brain Disorders and Non invasive diagnosis on non alcoholic steatohepatitis and of significant/severe fibrosis among patients with non alcoholic fatty liver disease. Sicilia Digestive, Kidney and Urological Systems Autoimmune encephalopaties: better characterization of the antibody profile CARLO BESTA Brain Disorders and Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary Biomarkers and prognostic factors in psoriasis and psoriatic arthritis: a prospective cohort study Lombardia Musculoskeletal, Oral and Skin Sciences Telemedicine in cardiology:training of a virtual team SAN RAFFAELE PISANA Healthcare Delivery and Pagina 33 di 142

34 Impact of diet in shaping gut microbiota revealed by a prospective dietetic study of African children consuming a Western diet DE BELLIS Endocrinology, Metabolism, Nutrition and Reproductive Sciences RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia Romagna Oncology Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia Brain Disorders and EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Istituto Superiore di Sanita' Infectious Diseases and Microbiology AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR TREATMENT OF CHRONIC END STAGE LIVER DISEASE (ESLD) Emilia Romagna Digestive, Kidney and Urological Systems Phenotypes in Dislexia with genetic alteration: sensory and neuronal deficits STELLA MARIS Integrative, Functional, and Cognitive Structural and functional large scale brain networks across multiple sclerosis clinical phenotypes: a graph theory approach to identify neuronal system vulnerability as a target of future therapeutic interventions Brain Disorders and Implementation of a fracture liaison service for the identification, evaluation and management of patients with osteoporotic fractures Toscana Healthcare Delivery and Etiopathogenetic, diagnostic and prognostic role of hypermethylation and downregulation of IRX1 gene inducedby H. pylori infection in patients with gastric cancer. Oncology Pagina 34 di 142

35 HPV INFECTION IN A COHORT OF HIV POSITIVE MEN AND WOMEN: VIRO IMMUNOLOGICAL CORRELATES OF HPV DISEASE PROGRESSION AT GENITAL AND ORAL SITES Lombardia AIDS and Related Research Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment of the neurocognitive and clinical outcomes of premature newborns Brain Disorders and Preemptive donor lymphocyte infusions guided by realtime PCR host donor microchimerism for prevention of leukemia relapse after haploidentical stem cell transplantation Oncology Amelioration of diagnosis and therapy of steroid resistant nephrotic syndrome: a novel treatment approach by umbilical cord blood mesenchymal stem cells. MAGGIORE Digestive, Kidney and Urological Systems Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Digestive, Kidney and Urological Systems TIPS FOR DECOMPENSATED CIRRHOSIS: A RANDOMIZED NICAL TRIAL Sicilia Surgical Sciences, Biomedical Imaging, and Bioengineering Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' Endocrinology, Metabolism, Nutrition and Reproductive Sciences Target definition of tumors in positron emission tomography: development and validation of a software tool to be installed on radiotherapy treatment planning systems Piemonte Oncology Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer, cardiovascular diseases and neurodegenerative disorders in healthy subjects. SAN RAFFAELE PISANA Population Sciences and Epidemiology Pagina 35 di 142

36 SMALL PEPTIDES AS A NEW STRATEGY FOR THE THERAPY OF CELIAC DISEASE Istituto Superiore di Sanita' Digestive, Kidney and Urological Systems Short and long term effects of ART in restoring intestinal mucosal immunity and reducing systemic immune activation in HIV infected patients. WHOLE EXOME SEQUENCING TO IMPROVE DIAGNOSTIC, PROGNOSTIC AND LOGICAL CHARACTERIZATION OF AML WITH NORMAL KARYOTYPE Istituto Superiore di Sanita' AIDS and Related Research Umbria Vascular and Hematology Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenic brain malformation CARLO BESTA Brain Disorders and WNT signaling in the pathogenesis and treatment of Bipolar Disorder Brain Disorders and Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Infectious Diseases and Microbiology Adoptive therapy with tolerogenic T regulatory type 1 (Tr1) cells in islet transplanted T1D patients Immunology In vivo identification of molecular determinants critical to the metastatic process in melanoma I.E.O. Oncology 1 Basic Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. SAN RAFFAELE PISANA Infectious Diseases and Microbiology NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Brain Disorders and Imaging and radioimmunotherapy of pancreatic cancer I. O. V. Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 36 di 142

37 Hypothesized points of convergence in the pathogenesis of Alzheimer's disease, frontotemporal lobar dementia, schizophrenia and bipolar disorder with therapeutic implications Brain Disorders and Pentraxin 3 as a predictive biomarker of hemorrhagic transformation following acute stroke NEUROMED Brain Disorders and MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model Istituto Superiore di Sanita' Infectious Diseases and Microbiology In vivo analysis of the interactions between exogenouly administred mesenchymal stromal cells and primary acute leukemia cells or leukemia initiating cells growing in NOG mice: implications for selective delivery of anticancer drugs to leukemic niches GASLINI Oncology 1 Basic Evaluation of oxidative stress and inflammation in blood as possible non invasive markers for progression of alcoholic liver disease. IRCCS AOU San Martino IST (Genova) Digestive, Kidney and Urological Systems GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS.EFFECT OF MUTATIONS OF APOB AND ANGPTL3 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Emilia Romagna Cardiovascular and Steroid myopathy: pathogenies and prevention MAUGERI Musculoskeletal, Oral and Skin Sciences How innate immunity enhances aggressiveness of colorectal carcinoma in HIV individuals AIDS and Related Research Pre clinical evaluation of safety and efficacy of intraarterial infusion of mesenchymal stems cells in experimental models of neurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Brain Disorders and A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Biobehavioral and Behavioral Processes Pagina 37 di 142

38 Cell stress mediators in cancer stroma interaction as targets for drug development SDN Oncology 1 Basic mirna driven conditional attenuation of viral vaccines Infectious Diseases and Microbiology Targeting Hedgehog and Colony Stimulating Factor 1 pathways in triple negative breast cancers Toscana Oncology Innovative procedures for Transcranial Magnetic Stimulation of neuro patients, also in vegetative state NEUROLESI Surgical Sciences, Biomedical Imaging, and Bioengineering Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications Emilia Romagna Cardiovascular and Thematic network on Bovine Diarrhoea Virus (BVDV) to improve tools and strategies for BVDV control in Italy Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10, Prevalence of Neonatal Adverse Outcomes and Their Risk Factors and Study on Adverse Medication Effects on the Newborn Health. Veneto Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10, Assessing antibiotic resistance in nonpathogenic foodrelated bacteria: the impact on human gut microbiota Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 10, Campylobacter, L. monocytogenes and Verocytotoxinproducing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary 10, Human Cytomegalovirus (HCMV) specific T cell immunity monitoring and inflammatory response analysis in solid organ transplant recipients: from pathogenesis to clinical application Toscana Infectious Diseases and Microbiology 10, Pagina 38 di 142

39 Studying the tumour microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma: the role of Mesenchymal stem cells C.R.O. AVIANO Oncology 1 Basic 10, Allergy management based on the neonatal risk: a technological pathway. SAN MATTEO Risk, Prevention and Health Behavior 10, SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche Brain Disorders and 10, Prospective multicenter study on the efficacy of a new, taylored on risk class, antibiotic prophylaxis protocol in preventing neurosurgical Surgical Site Infection (SSIs). Lombardia Infectious Diseases and Microbiology 10, Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy and give new insight into monogenic type 2 diabetes. OSPEDALE BAMBINO GESU' Digestive, Kidney and Urological Systems 10, New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Surgical Sciences, Biomedical Imaging, and Bioengineering 10, Proposal for a multidisciplinary integrated approach to the health management of myotonic dystrophy type 1 (DM1) SAN RAFFAELE PISANA Healthcare Delivery and 10, The effect of pulmonary rehabilitation on the reduction of acute exacerbations in patients with COPD. The impact of inflammatory phenotype DON GNOCCHI Cardiovascular and 10, Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia Immunology 10, Role of Innate Immunity, Inflammasome and RAAS in the progression of type 2 diabetes through the regulation of hepatic, cardiovascular and endothelial function Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10, Pagina 39 di 142

40 Validation in genetic mouse models and in human cells of two gene therapy approaches against striatal degeneration and Huntington's Disease Brain Disorders and 10, In vitro and in vivo effects of post transplant cyclophosphamide as novel immunosuppressive regimen for hematopoietic stem cell transplantation from partially HLA matched donors IRCCS AOU San Martino IST (Genova) Immunology 10, Localizing the epileptogenic zone in presurgical evaluation of drug resistant focal epilepsies: a complex network based approach CARLO BESTA Surgical Sciences, Biomedical Imaging, and Bioengineering 10, Comparative analysis of the leukemia associated fusion proteins TEL/AML1 and AML1/ETO. I.E.O. Vascular and Hematology 10, Simultaneous inhibition of PARP and homologous recombination: a new hypothesis for radiosensitization ONCOLOGICO DI BARI Oncology 2 10, Pathogenesis of bone alterations in chronic liver diseases: study and identification of cellular and molecular mechanisms. AUXOLOGICO Musculoskeletal, Oral and Skin Sciences 10, The adenosine receptors: potential targets for diagnosis, prognosis and therapy of cancer Emilia Romagna Oncology 2 10, IN VITRO GENERATION OF HEMOGENIC ENDOTHELIUM FROM HUMAN CORD BLOOD: A NEW TOOL FOR STUDYING THE DEVELOPMENT OF THE HEMATOPOIETIC SYSTEM AND FOR REGENERATIVE MEDICINE Istituto Superiore di Sanita' Cell Biology 10, Macrophage polarization and HIV infection. A model of multiple restrictions of the virus life cycle. AIDS and Related Research 10, Insight into molecular events involved in the cooperation between bcl 2/bcl xl and hypoxia in the regulation of tumor progression and angiogenesis REGINA ELENA Oncology 1 Basic 10, Investigation of a novel engineered probiotic to treat Clostridium difficile infection Infectious Diseases and Microbiology 10, Pagina 40 di 142

41 Development of an exosome based in vivo test to detect prions in blood Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Molecular, Cellular, and Developmental 10, Study of the P2RX7 gene coding the purinergic P2X7 receptor for extracellular ATP, as a susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms identified in a cohort of ALS patients. SANTA LUCIA Brain Disorders and 10, Treatment of Neurological Impairment in Lysosomal StorageDiseases by the Use of Neural Stem Cells CASA SOLLIEVO SOFFERENZA Molecular, Cellular, and Developmental 10, Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections. Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 10, EXOME RESEQUENCING IN UNEXPLAINED RARE BLEEDING DISORDERS MAGGIORE Genes, Genomes and Genetics 10, NEW MOLECULES AS DISEASE MODIFYING DRUGS FOR OSTEOARTHRITIS TREATMENT Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 10, Neurobiological, pharmacological and clinical studies on Attention Deficit Hyperactivity Disorder (ADHD): from patients to animal models and back. STELLA MARIS Brain Disorders and 10, Patient specific Induced Pluripotent Stem Cells (ipscs) to model neurodegeneration and to test gene therapy approaches in Lysosomal Storage Disorders (LSDs). Genes, Genomes and Genetics 10, THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS MONDINO Molecular, Cellular, and Developmental 10, Structural analysis of nucleophosmin as a target for acute myeloid leukemia treatment Abruzzo Biological Chemistry and Macromolecular Biophysics 10, Pagina 41 di 142

42 An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 10, Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress OSPEDALE BAMBINO GESU' Vascular and Hematology 10, A cooperative translational study focused on inflammation and eicosanoids to identify mechanism and predictors of preeclampsia Veneto Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10, Study on the Mammalian Target of Rapamycin (mtor) signaling pathway as a potential antiepileptogenic therapy Calabria Brain Disorders and 10, GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS AS A DRUGGABLE TARGET TO DEVELOP A PHARMACOLOGICAL STRATEGY IN ALEXANDER DISEASE GASLINI Genes, Genomes and Genetics 10, Expression of estrogen receptors and neuroglobin as a new tool to assess stratification of Parkinson's disease patients Piemonte Brain Disorders and 10, Molecular determination of Salmonella serovars by using microsphere based suspension array Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 10, Combination of carfilzomib and pomalidomide, two last generation proteasome inhibitor and immunomodulating agents, for the treatment of patients with multiple myeloma relapsed after or refractory to lenalidomide: an international (EMNTG) phase I II clin CROB Oncology 2 10, System biology approach to define etiology and pathogenesis of idiopathic non histaminergic angioedema with normal C1 inhibitor Lombardia Genes, Genomes and Genetics 10, Pagina 42 di 142

43 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR SENTINELS FOR INFECTIOUS DISEASES? Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 10, Prof of Concept combination strategy for HIV prevention and control: does microbicide during vaccination impact on B cell immune responses? AIDS and Related Research 10, Chronic kidney disease and cardiovascular risk in Italy. A population based longitudinal study exploiting the CNESPS ISS biological specimen bank Istituto Superiore di Sanita' Population Sciences and Epidemiology 10, Striatal synaptic plasticity in experimental models of Parkinson's disease with different degrees of dopamine denervation: molecular mechanisms and therapeutics implications SANTA LUCIA Brain Disorders and 10, PRENICAL DEVELOPMENT OF NOVEL SMALL ANDROGEN RECEPTOR MODULATING MOLECULES (SARMS) IN EXPERIMENTAL HUMAN PROSTATE CANCER MODELS Emilia Romagna Oncology 2 10, AN INNERVATED TISSUE ENGINEERING APPROACH TO RECONSTRUCT THE ESOPHAGUS Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 10, Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO Oncology 2 10, Pathogenetic role and potential clinical exploitation of the CCL2/CCR2 axis in the regulation of immune responses in ALS HUMANITAS Immunology 10, Validation of a prognostic multigene classifier for larynx carcinoma, application to fine needle biopsies and functional analyses of classifier genes IRCCS AOU San Martino IST (Genova) Oncology 2 10, IMPLEMENTATION AND TESTING OF AN E HEALTH BASED SYSTEM FOR EARLY DIAGNOSIS AND INTERVENTION ON SPECIFIC READING DISORDERS MEDEA Healthcare Delivery and 10, Pagina 43 di 142

44 Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis. Emilia Romagna Infectious Diseases and Microbiology 10, Fast tracking of proximal femur fractures: evaluation of the efficacy by means of quantitative neuromotor conditions assessment at mid time follow up. RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 10, Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study. ARCISPEDALE Healthcare Delivery and 10, Bilateral sequential lung and pancreas transplantation and combined en bloc liver pancreas transplantation in patients with cystic fibrosis Lombardia Surgical Sciences, Biomedical Imaging, and Bioengineering 10, A study on the economic and social burden of Parkinson s Disease in Italy and a cost benefit analysis of disease modifying therapies. SAN RAFFAELE PISANA Healthcare Delivery and 10, Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedule in patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna Oncology 2 10, alpha7 nachr status and response to donepezil in AD patients SAN RAFFAELE PISANA Brain Disorders and 10, TELE PHYSICO TELEMEDICINE FOR PHYSICAL HEALTH PROMOTION IN TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre randomised controlled trial. FATEBENEFRATELLI Risk, Prevention and Health Behavior 10, Governance of diabetes management in non specialistic hospital settings. Emilia Romagna Healthcare Delivery and 10, Telemonitoring in Heart Failure Liguria Bioengineering Sciences and Technologies 10, Pagina 44 di 142

45 Prognostic role of serum pro PSA, circulating tumor cells and serum testosterone levels in prostate cancer patients with biochemical progression undergoing androgen deprivation therapy Piemonte Oncology 2 10, EXPERIMENTAL EVIDENCES ON POSSIBLE TOXIC EFFECTS OF LEVODOPA ON MAMMALIAN SUBSTANTIA NIGRA DOPAMINERGIC NEURONS SANTA LUCIA Brain Disorders and 10, EVALUATION OF THE ROLE OF HPV INDUCED IMMUNE RESPONSE IN VACCINE RELATED EFFICACY: COMPARISON BETWEEN BIVALENT AND QUADRIVALENT HPV VACCINES IN FEMALES AND MALES MAGGIORE Risk, Prevention and Health Behavior 10, Staphylococcal enterotoxin in traditional raw ewe milk Pecorino cheese: risk assessment and proteomic characterization Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 10, TRAIN: Training through Research Application Italian initiative Istituto Superiore di Sanita' Interdisciplinary Molecular Sciences and Training Exploiting the therapeutic and prognostic potential of micrornas in melanoma ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology Glioblastoma multiforme long survivors: impact of molecular profile on prognosis Toscana Oncology Allergens, chemical and biological contaminants in nursery and primary schools: a proposal of a multimethod approach for the assessment of the main risk pollutants Istituto Superiore di Sanita' Risk, Prevention and Health Behavior New therapeutic strategies for the control of fungal infections in the elderly Istituto Superiore di Sanita' Infectious Diseases and Microbiology Nanoparticle delivered gene therapy to overcome remyelination failure resulting from blocked mature oligodendrocytes in multiple sclerosis like disease CARLO BESTA Brain Disorders and Pagina 45 di 142

46 Estimation of cured patients among persons living with neoplasms C.R.O. AVIANO Population Sciences and Epidemiology Characterization of anal HPV infection and associated lesions in immunocompetent and immunocompromised hosts. SAN GALLICANO Oncology 1 Basic Role of the ghrelin gene derived peptides and growth hormone releasing hormone (GHRH) on microrna expression and function in the heart Piemonte Cardiovascular and Application of molecular techniques to identify zoonosis agents transmitted by arthropods. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary The role of mirna in MYC regulatory network Toscana Oncology 1 Basic IDENTIFYING CORRELATIONS BETWEEN GENOTYPES AND PHENOTYPES OF DENT'S DISEASE. PARTICIPATION TO THE INTERNATIONAL DENT S DISEASE REGISTRY Veneto Digestive, Kidney and Urological Systems Development of novel drugs targeting protozoan agents of tropical diseases imported in Italy Istituto Superiore di Sanita' Infectious Diseases and Microbiology Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease. Istituto Scienze Neurologiche Brain Disorders and Common pathogenic pathways in Motor Neuron Diseases : a study on the relation between SMN and TLS/FUS SANTA LUCIA Molecular, Cellular, and Developmental Pagina 46 di 142

47 MESOANGIOBLASTS FOR THE CELL THERAPY OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING SKELETAL MUSCLE DIFFERENTIATION OF FSHD MESOANGIOBLASTS IN VITRO AND IN VIVO IN SCID MICE AND IN A MOUSE MODEL OF FSHD. DON GNOCCHI Musculoskeletal, Oral and Skin Sciences GENETIC DETERMINANTS OF LEFT VENTRICULAR HYPERTROPHY AUXOLOGICO Cardiovascular and Exploiting the p53 p66shc signalling pathway to identify new molecular markers for the prevention of cancer and age related diseases I.E.O. Biology of Development and Aging Low dose effects: in vivo models of chemotherapyradiation therapy interactions Emilia Romagna Oncology ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCERCHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences Immunesurveillance of leukemia by CD1 restricted T cells specific for self lipid antigens Immunology Sp140 PHD finger as a potential target for chronic lymphocytic leukemia: a multidisciplinary approach Biological Chemistry and Macromolecular Biophysics Role of IL 4 producing granulocytes in thymic stromal lymphopoietin dependent Th2 type inflammation in pancreatic cancer Immunology gene environment and gene gene association analyses on cognitive phenotypes in Italian nuclear families of dyslexia MEDEA Brain Disorders and Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration : role of genome instability associated with tau mutations CARLO BESTA Brain Disorders and Safety and efficacy of infusion of human adipose derived mesenchymal cells in experimental models of whole and partial liver transplantation in large size animals. Emilia Romagna Digestive, Kidney and Urological Systems Pagina 47 di 142

48 LOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary Perinatal stress in human and non human offspring: a translational approach to study epigenetic impact on depression. Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes Evaluation of Opisthorchis felineus metacercariae infectivity after fish fillets freezing at different timetemperature combinations. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary Genetic polymorphisms and noninvasive scores for screening patients with progressive non alcoholic fatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Digestive, Kidney and Urological Systems Study of basic and clinical aspects of mitotane treatment in patients with adrenocortical carcinoma. Piemonte Oncology Quantitative evaluation of the function of the elbow operated through inertial devices RIZZOLI Musculoskeletal, Oral and Skin Sciences Diagnostic impact of circulating mirna and cancer cells in poorly differentiated carcinomas of the lung and breast. Emilia Romagna Oncology Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences VALIDATION OF NANOPARTICLES FOR DRUG DELIVERY IN HEREDITARY NEUROMUSCULAR DISEASES TREATMENTS OSPEDALE BAMBINO GESU' Molecular, Cellular, and Developmental Disentangling prenatal and postnatal influences on infant bio behavioral development: a prospective study. MEDEA Biobehavioral and Behavioral Processes Pagina 48 di 142

49 Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES CROB Vascular and Hematology GENOMIC VARIATION AND PROTEOMIC PROFILE IN NEONATAL BRONCOPULMONARY DYSPLASIA AND RESPIRATORY DISTRESS NICAL SPECTRUM Genes, Genomes and Genetics ABCB1/P glycoprotein expression: a biological stratification of the risk in patients with non metastatic osteosarcoma of the extremity. An Italian Sarcoma Group prospective study (ISG/OS 2). Emilia Romagna Oncology Hypothesis driven gene candidate study of copper involvement in the pathogenesis of Alzheimer s disease: detection of sequence changes, haplotype profile of ATP7B gene and their molecular and functional aspects SAN RAFFAELE PISANA Brain Disorders and INVESTIGATING PROGRESSION FROM PRENEOPLASTIC TO NEOPLASTIC DISEASE IN ESOPHAGEAL AND PANCREATIC CANCER BY MEANS OF AN INTEGRATIVE GENOMICS NEXT GENERATION SEQUENCING BASED APPROACH. Digestive, Kidney and Urological Systems Amantadine treatment for pathological gambling FATEBENEFRATELLI Brain Disorders and DISCHARGE FROM FORENSIC MENTAL HOSPITALS, COMMUNITY TENURE, AND RISK OF RECIDIVISM: A PROSPECTIVE FOLLOW UP STUDY Lombardia Healthcare Delivery and Pagina 49 di 142

50 Treatment optimization of recurrent glioblastoma Emilia Romagna Oncology Person/Patient and Family centred care PCC & FCCUnderstanding health care experiences and perceptions of parents of hospitalized premature infants, children with a chronic condition and their parents and health professionals in South Tyrol and other reg Provincia autonoma Bolzano Healthcare Delivery and HBV related chronic hepatitis: bone metabolism study in naïve patients and in long term therapy with nucleos(t)ide analogue Piemonte Digestive, Kidney and Urological Systems Multicenter,Italian,randomized,open label,parallelgroup, non inferiority phase III clinical trial comparing cisplatin 5Fluorouracil cetuximab vs. carboplatinpaclitaxel cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck Lombardia Oncology PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) AMONG ITALIAN REGIONS Lazio Risk, Prevention and Health Behavior Effect of lower limb end effector robot assisted therapy with body weight support vs treadmill gait training in Parkinson Patients. SAN RAFFAELE PISANA Brain Disorders and New paradigms for Tuberculosis (TB) management using rapid molecular detection of Mycobacterium tuberculosis and Rifampin resistance Emilia Romagna Infectious Diseases and Microbiology Whole Exome sequencing a novel modality for diagnostics and disease gene discovery in Cardiomyopathies MULTIMEDICA Genes, Genomes and Genetics An Italian multidisciplinary clinic for Wolfram Syndrome GASLINI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Role of acetylcholinesterase R in the treatment of Myastenia Gravis. SAN RAFFAELE PISANA Oncology Pagina 50 di 142

51 Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO Oncology Multimodal evaluation of stroke patient's mindbrain state during upper limb robot aided therapy SAN RAFFAELE PISANA Emerging Technologies and Training in s DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO Emerging Technologies and Training in s Integrated approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and long term auxological, neurodevelopmental and metabolic outcomes Piemonte Risk, Prevention and Health Behavior Efficacy of a neuromotor and cognitive behavioural training for disability, kinesiophobia and gait disturbances in chronic non specific low back pain MAUGERI Musculoskeletal, Oral and Skin Sciences Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening AUXOLOGICO Healthcare Delivery and Biological nurturing and exclusive breastfeeding at 12 weeks: a randomised controlled trial BURLO GAROFALO Healthcare Delivery and DEVELOPMENT OF A THYROID CANCER DATABASE TO IMPROVE THE QUALITY OF NICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Lazio Oncology Early integration of palliative care with standard oncologic care in advanced non small cell lung cancer. A prospective, multi center observational study to evaluate how this approach impact on patient s survival and quality of life with an additional ana I. O. V. Healthcare Delivery and SENESCENCE ASSOCIATED micrornas (SAmiRs) IN CELLULAR SENESCENCE AND ORGANISMAL AGING SDN Biology of Development and Aging 11, Pagina 51 di 142

52 Proteomic signatures as biomarkers of breast cancer risk andas predictors of outcome in women with early breast cancer. IRCCS AOU San Martino IST (Genova) Oncology 2 11, Mobile genetic elements: new approaches to molecular epidemiology of antimicrobial resistance genes in Gramnegative clinical isolates Abruzzo Infectious Diseases and Microbiology 11, Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severe Gram positive infections Toscana Healthcare Delivery and 11, Citicoline treatment for traumatic brain injury NEUROLESI Brain Disorders and 11, A randomized multi center study for the evaluation of efficacy and safety of two different daily doses of low molecular weight heparin (LMWH) in subjects with cancer and incidentally detected non symptomatic pulmonary embolism SAN MATTEO Cardiovascular and 11, Electronic Medical Record for PDD: A powerful tool for health care, clinical governance and epidemiological studies Istituto Superiore di Sanita' Healthcare Delivery and 11, Genotoxicity, biochemical and tissutal responses in aquatic organisms exposed to chlorpyrifos and deltamethrin, assessing their risk for animal and human health Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 11, Identification of signaling pathway activation profiles in cancer stem cells by mass cytometry, comparison with the reverse phase protein array approach and correlation with sensitivity to pathway targeting drugs. Istituto Superiore di Sanita' Oncology 1 Basic 11, Cotransplantation of pancreatic islets and engineered third party human umbilical cord mesenchymal stem cells. A novel approach to increase graft survival and immune tolerance in type 1 diabetes patients Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11, Pagina 52 di 142

53 Cutaneous sensory and autonomic innervation in early parkinsonism. A new tool to predict clinical evolution toward PD, MSA and PSP. MAUGERI Brain Disorders and 11, Neurophysiological approach to evaluate cerebrocerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA Brain Disorders and 11, High throughput monitoring of pathogen specific cellular immunity as guidance for treatment of opportunistic infections in immunocompromised children. OSPEDALE BAMBINO GESU' Immunology 11, Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach Brain Disorders and 11, Targeting patients with recurrent depression and traumas: Comparison of the efficacy of EMDR and of CBT versus standard clinical management, their neurobiological correlates, and the associated health sanitary costs. Piemonte Biobehavioral and Behavioral Processes 11, A Pharmacogenomic Approach to Retinal Neuroprotection in Age Related Macular Degeneration. Lazio Cell Biology 11, Reducing the need for intensive care unit in hospitalized patients with early respiratory failure using the noninvasive ventilation technique. A multicentre randomized study. Surgical Sciences, Biomedical Imaging, and Bioengineering 11, Prospective Study on infectious complications in patients receiving biological drugs, either monoclonal antibodies or TNF alpha antagonists. Emilia Romagna Infectious Diseases and Microbiology 11, Virus associated tumors: identification of novel diagnostic, prognostic and treatment strategies SAN MATTEO Oncology 2 11, Health and equity effects of natural policy experiments in the fields of structural policies and health care organization Piemonte Healthcare Delivery and 11, Pagina 53 di 142

54 The treatment adherence in children and adolescents with Spina Bifida and neurogenic bladder: relations with demographic, medical, occupational, cognitive and psycho social variables. Lombardia Healthcare Delivery and 11, and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Toscana Musculoskeletal, Oral and Skin Sciences 11, ZnO nanoparticles as selective killers of liver metastasis derived from colon cancer SAN MATTEO Bioengineering Sciences and Technologies 11, IDENTIFICATION OF MOLECULAR MECHANISMS INVOLVED IN SYNOVIAL OSTEOCHONDROMATOSIS PATHOGENESIS Toscana Musculoskeletal, Oral and Skin Sciences 11, Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines Toscana Immunology 11, Development of innovative rapid screening methods of corticosteroids agents in cattle as growth promoters using MEA and an enhanced histopathological approach Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 11, and Molecular aspects of Sunitinib related hyperlipidemia. Toscana Oncology 2 11, Effect of exposure to environmental and food contaminants, on bone and liver diseases. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 11, Brain Tumor Banking: a tool for research, diagnosis and therapy MONDINO Oncology 1 Basic 11, Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 11, Pagina 54 di 142

55 Role of CREB protein family members in human lymphoid malignancies Abruzzo Cell Biology 11, Protective role of high density of tumor associated macrophages in stage III colorectal cancer HUMANITAS Oncology 2 11, GENE EXPRESSION PROFILING IN HUMAN ACTH SECRETING PITUITARY TUMORS IN ASSOCIATION WITH NICAL AND CHEMICAL FEATURES. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11, Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies Sicilia Vascular and Hematology 11, Viral respiratory infections in intensive care patients. Toscana Infectious Diseases and Microbiology 11, MITO 7 A Multicenter phase 3 Randomized Study with weekly paclitaxel in patients with Ovarian Cancer treated with first line chemotherapy PASCALE Oncology 2 11, An epigenetic approach to treatment of triple negative breast cancer Friuli Venezia Giulia Oncology 1 Basic 11, Management of couples with asymptomatic urogenital infections and ART failure Toscana Infectious Diseases and Microbiology 11, Novel predictive biomarkers for bevacizumab in colorectal cancer I. O. V. Oncology 2 11, Reproductive toxicity of Engineered Nanomaterials: mechanisms, effects, biomonitoring and tools for prevention Lazio Bioengineering Sciences and Technologies 11, Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Integrative, Functional, and Cognitive 11, GABAA receptor and chloride transporter physiopathological role in ALS SANTA LUCIA Molecular, Cellular, and Developmental 11, Pagina 55 di 142

56 EFFECTS OF NUTRACEUTICAL SPIRULINA AND DOCOSAHEXAENOIC ACID ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENT AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY Istituto Superiore di Sanita' Molecular, Cellular, and Developmental 11, Identification of EphA3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutic approach with a specific monoclonal antibody CROB Oncology 1 Basic 11, LOW INVASIVE MARKERS DEVELOPMENT IN COLLAGEN 6 MYOPATHIES AND DUCHENNE MUSCULAR DYSTROPHY FOR DISEASE STAGING AND RESPONSE TO TREATMENT RIZZOLI Musculoskeletal, Oral and Skin Sciences 11, Proteomics and metabonomics strategies to characterize functional biomarkers of Polycyclic aromatic hydrocarbons contamination on dairy products Abruzzo Veterinary 11, Telemedicine for monitoring of asthmatic patients Evaluation of the outcome of treatment accordin to the style of life. OSPEDALE BAMBINO GESU' Risk, Prevention and Health Behavior 11, Posttraumatic stress disorder in parents of children with surgically correctable anomalies requiring surgery at birth OSPEDALE BAMBINO GESU' Biobehavioral and Behavioral Processes 11, Sharing of medical resources for the diagnosis and treatment of status epilepticus by a computer assisted telemedicine system Emerging Technologies and Training in s 11, In vivo manipulation of gamma delta T cells with zoledronate and low dose IL 2 for immunotherapy of malignant melanoma Sicilia Oncology 2 11, value of decompressive craniectomy associated to haematoma evacuation in the first 72 hours after traumatic events: a multicenter randomized controlled trial Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 11, Pagina 56 di 142

57 A novel in vivo system for functional reconstitution of bone and a functional bone marrow microenvironment/hematopoietic stem cell niche: a lead into scaffold free, cell only bone regeneration strategies, and into direct modeling of leukemic and cancer st Lazio Vascular and Hematology 11, Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 11, Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A preclinical study. Istituto Superiore di Sanita' Oncology 2 11, DELIVERY OF THERAPEUTICAL AGENTS INTO MELANOMA BY TGF β SWITCH DEPENDENT HOMING OF MESENCHYMAL STEM CELLS (MSC), ENDOTHELIAL PROGENITOR CELLS (EPC) AND ANTIGEN PRESENTING CELLS (APC) Toscana Oncology 1 Basic 11, Fertility preservation in women affected by endometriosis through oocyte vitrification Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11, The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Emilia Romagna Brain Disorders and 11, Molecular determinants of immune evasion in childhood acute leukemia. OSPEDALE BAMBINO GESU' Immunology 11, Combined therapeutic cancer vaccine strategy for HCVrelated HCC PASCALE Oncology 2 11, Quantitative Advanced Imaging (PET/MRI) in the Surgery and Radiotherapy of High Grade Brain Tumours ARCISPEDALE Oncology 2 11, IDENTIFICATION OF GENES REGULATING SKIN FIBROSIS IN SCLERODERMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 11, Pagina 57 di 142

58 Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cells and gamma/delta T lymphocytes and regulation of their cross talk. TAT AND ENV BIND TO FORM A NOVEL HIV ENTRY COMPLEX THAT TARGETS CELLS AT THE PORTAL OF ENTRY AND HIV RESERVOIRS: IMPLICATIONS FOR THE DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC INTERVENTIONS AGAINST HIV/AIDS Istituto Superiore di Sanita' Immunology 11, Istituto Superiore di Sanita' AIDS and Related Research 11, Caveolin 1, PTRF expression and function in Non Small Cell Lung Cancer. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 11, Rethinking neuroinflammation in sporadic AD: exploring novel therapeutic and prognostic tools Istituto Superiore di Sanita' Brain Disorders and 11, Targeting epithelial to mesenchymal transition and chemoresistance mediated by endothelin 1 signaling in epithelial ovarian cancer REGINA ELENA Oncology 1 Basic 11, BPIFB4 longevity associated variants: evaluation by in vitro and in vivo studies for their potential modulation of diseases of aging MULTIMEDICA Biology of Development and Aging 11, Role of Dbl in epithelial cell transformation: identification of new therapeutic targets for carcinomas Liguria Oncology 1 Basic 11, Evaluation of the role of Copy Number Variations in the pathogenesis of inherited neurological and neuromuscular disorders through the development and validation of a rapid and efficient laboratory assay IRCCS AOU San Martino IST (Genova) Genes, Genomes and Genetics 11, Epigenetic therapy of leukemic stem cells in acute myeloid leukemias. I.E.O. Oncology 1 Basic 11, Beta adrenergic receptor blockade as a new, effective and safe therapy in the treatment of retinopathy of prematurity Toscana Cell Biology 11, Pagina 58 di 142

59 Rehabilitation of somatic deficits after stroke through training and non invasive brain stimulation AUXOLOGICO Integrative, Functional, and Cognitive 11, WHOLE EXOME SEQUENCING OF ADENOMATOUS POLYPOSIS PATIENTS FOR A GENETIC DIAGNOSIS AND NICAL APPLICATIONS C.R.O. AVIANO Oncology 1 Basic 11, DEVELOPMENT OF A NETWORK BASED MODEL FOR A COMPREHENSIVE NICAL DIAGNOSTIC MANAGEMENT OF HEREDITARY CANCER PATIENTS AND THEIR FAMILY MEMBERS I. O. V. Healthcare Delivery and 11, Caffeine as a potential therapeutic option for Alzheimer's disease. Istituto Superiore di Sanita' Brain Disorders and 11, Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA Biobehavioral and Behavioral Processes 11, Tailoring micro nanocarriers structural and surface properties to finely modulate the activation or regulation of immune responses: the allergy immunotherapy proof of concept Istituto Superiore di Sanita' Immunology 11, Nutritional factors in Rett syndrome and autism spectrum disorders: preclinical evaluation of dietary choline during early developmental phases Istituto Superiore di Sanita' Brain Disorders and Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Bioengineering Sciences and Technologies Diagnosis and pathogenesis of Opisthorchis felineus, an emerging foodborne parasite in Italy Istituto Superiore di Sanita' Infectious Diseases and Microbiology Hypoxia, inflammation and stem cells in cancer progression SAN RAFFAELE PISANA Oncology 1 Basic Roles of ADP ribosylation in the regulation of the actin cytoskeleton and intracellular Ca2+ signaling Abruzzo Cell Biology Pagina 59 di 142

60 NF kb signaling pathway,innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI Brain Disorders and Development of a novel test for detection of Bacillus anthracis DNA in urine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Infectious Diseases and Microbiology NEW DRUGS FOR BONE MASS RECOVER IN OSTEOPOROTIC PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS (RA): NICAL/MEDICAL STUDY. Emilia Romagna Musculoskeletal, Oral and Skin Sciences Identification of gender related differences in oxidative stress biomarkers associated with atherosclerotic disease progression Istituto Superiore di Sanita' Cardiovascular and COPD global proteomics: a systems biology approach. SAN RAFFAELE PISANA Cardiovascular and Normal and pathological development of locomotion in the first year of life SANTA LUCIA Brain Disorders and Sentinel animals to monitor pollution around the former Balangero asbestos mine Piemonte Population Sciences and Epidemiology SAFE FISH: safety and nutritional value assessment of Italian marine farmed fish Istituto Zooprofilattico Sperimentale della Sicilia Healthcare Delivery and A new approach to cancer early diagnosis based on the identification of breast cancer related metabolites in human breath ISTITUTO TUMORI MILANO Oncology Italian study on gene environment interactions in lymphoma aetiology: translational aspects Toscana Oncology 1 Basic PanCareSurFupPanCare Childhood and Adolescent Cancer Survivor Care and Follow up Studies, Italian branch Piemonte Oncology Pagina 60 di 142

61 Characterization of the role of HIV1 Tat in establishment and maintenance of viral reservoirs: implications for new strategies toward HIV eradication Emilia Romagna AIDS and Related Research Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana Oncology 1 Basic Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood Abruzzo Genes, Genomes and Genetics Gene expression profile at the onset of severe cardiac failure:identification and validation of new biomarkers Liguria Cardiovascular and mir34a: clarifying its value in prognosis and therapy of Ewing s sarcoma. RIZZOLI Oncology 1 Basic Novel immunotherapeutic strategies for the cure of human prostate cancer Immunology G15 expression in pancreatic cancer:its prognostic and diagnostic value as a clinical/molecular marker and as a pharmacological target Veneto Oncology 1 Basic Dissecting the molecular regulatory networks in human myeloid derived suppressor cells. I. O. V. Immunology Mechanisms of interplay between Mycobacterium avium subspecies paratuberculosis and intestinal cells in Crohn s disease Istituto Zooprofilattico Sperimentale delle Venezie Digestive, Kidney and Urological Systems Identification of downstream targets of BAG3/BRAFmediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma PASCALE Oncology Role of mir in the cytokine mediated regulation of gene expression in neoplastic B cells IRCCS AOU San Martino IST (Genova) Oncology 1 Basic Pagina 61 di 142

62 Effective functional measurements in musculoskeletal rehabilitation: guidelines, methodologies and tools for accreditation, assessment and appropriate performance of Movement Analysis Laboratories Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Emilia Romagna Immunology Protein profile of red blood cell and exosomes signature for early diagnosis of ovarian cancer Veneto Oncology Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary EPIGENETIC DETERMINANTS OF DRUG SENSITIVITY AND NICAL OUTCOME IN OVARIAN CANCER HUMANITAS Oncology Characterization of interactions among tumor, stromal and immune cells for the identification of potential targets in melanoma therapy. IRCCS AOU San Martino IST (Genova) Immunology Identification of immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease Isolation and characterization of interferon gammaproducing myeloid cells from the bone marrow of Severe Aplastic Anemia patients (SAA) Istituto Superiore di Sanita' Immunology GASLINI Vascular and Hematology Next Generation Targeted resequencing Panels as a tool for multi gene testing in the diagnosis of Parkinson Disorder SAN RAFFAELE PISANA Genes, Genomes and Genetics The role of oxidative damage to DNA and its repair in human gastrointestinal cancer Istituto Superiore di Sanita' Oncology 1 Basic Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences Pagina 62 di 142

63 Development of novel gene therapy approaches to cure the primary ciliary dyskinesia Toscana Cardiovascular and Development of an in vitro assay for the diagnosis of latent tuberculosis infection (LTBI) based on a novel human immunodominant T cell epitope of the antigen PPE44 of Mycobacterium tuberculosis Toscana Infectious Diseases and Microbiology Exploring the interactome of the high risk Human Papillomavirus oncoproteins to understand and dismantle its oncogenic power REGINA ELENA Oncology 1 Basic Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Toscana Brain Disorders and IDENTIFICATION OF MARKERS AND DEVELOPMENT OF SENSORS FOR EARLY PANCREATIC CANCER DIAGNOSIS Piemonte Bioengineering Sciences and Technologies A marker of homeostatic failure locates seizure onset zone in surgically remediable focal epilepsies CARLO BESTA Brain Disorders and Autoreactive T cell expansion profiles and mechanisms in patients with type I diabetes during beta cell replacement therapy Immunology HIV drug resistance in resource limited settings : an assessment in naïve pregnant women in Malawi and the evaluation of the impact of a triple antiretroviral combination strategy for PMTCT Istituto Superiore di Sanita' AIDS and Related Research Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma and in liver regeneration: mirnome and proteome analysis in experimental and clinical settings Istituto Superiore di Sanita' Oncology Discovery of small molecules capable of eliminating the HIV T cellular reservoir Istituto Superiore di Sanita' AIDS and Related Research Telomere Length, Risk of Ischemic Stroke and Prediction of Poststroke Recurrent Events NEUROLESI Brain Disorders and Pagina 63 di 142

64 Extreme Obesity and Sleep Apnoea Syndrome: Redox Balance, Inflammation and Vitamin Profile. Effect of metabolic rehabilitation and non invasive mechanical ventilation. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Prospective study in premanifest Huntington disease mutation carriers: new clinical and neuroradiological assessment tools for long term follow up and early signs evaluation CARLO BESTA Brain Disorders and Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana Genes, Genomes and Genetics REGENERATION OF SCAPHOID BONE DEFICIENCY BY USING AUTOLOGOUS EX VIVO EXPANDED, GMP GRADE, BONE MARROW MESENCHYMAL STEM CELLS Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering A comprehensive immunological strategy for the prevention of relapse in elderly patients with acute myeloid leukemia according to genotype: adoptive immunotherapy with NK cells and anti WT1 vaccination Emilia Romagna Oncology Health (cancer and atherosclerotic) risks from radiological medical imaging in grown up congenital heart disease patients Toscana Cardiovascular and Telecare and Home Care: assessing cost effectiveness of a new approach to increase safety in home care avoiding the need to hospitalize for elderly, polypathologic, chronically ill, unstable subjects with movement handicaps Toscana Healthcare Delivery and Sacral neuromodulation as treatment of urge incontinence in frail elderly female patients: a study of feasibility, safety and cost effectiveness analysis. Lazio Digestive, Kidney and Urological Systems Investigating Huntington disease stage related biomarkers in the nervous and cardiovascular systems NEUROMED Brain Disorders and Pagina 64 di 142

65 Individual risk for lung cancer and low dose CT Scan screening for occupationally ex exposed to asbestos. Toscana Oncology Fluidodynamics of Fontan operation: A data base aiming at improvement of surgical outcome of the univentricular heart OSPEDALE BAMBINO GESU' Cardiovascular and Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia Infectious Diseases and Microbiology A prospective study on Oxaliplatin neurotoxicity: from basic science to rehabilitation looking for early preclinical signs of neuropathy. S.CAMILLO Oncology A phase III study (IRMA3): breast cancer at low risk of local recurrence: irradiation and accelerated partial threedimensional conformal radiotherapy (3D CRT) versus standard radiotherapy and intraoperative radiotherapy(iort) versus standard radiotherapy Emilia Romagna Oncology Motor underpinnings to screen autism (MUSA). Prospective study on movement perception and performance in younger siblings of children with Autism Spectrum Disorders. Searching for clinical predictors and neural correlates of early autism. STELLA MARIS Brain Disorders and Prostate cancer and visceral obesity: an epidemiological, hormonal, metabolic and molecular study Veneto Digestive, Kidney and Urological Systems The reactivity to 35% CO2 challenge as predictor of pharmacological treatment outcome and relapse in Panic Disorder. Lombardia Biobehavioral and Behavioral Processes Collaborative model for the psychosocial care of the adult cancer patients and their caregivers: cluster, randomized trial to test a new way of care coordination. (HuCare 2: Humanization of cancer care, project 2) Lombardia Healthcare Delivery and Pagina 65 di 142

66 Endothelial Dysfunction and Insulin Resistance: an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signaling and cardiovascular damage Toscana Cardiovascular and Cerebellar transcranial magnetic stimulation as a treatment option for levodopa induced dyskinesias and tremor NEUROMED Brain Disorders and 12, Readthrough of Premature Termination Codons to treat Kabuki syndrome CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 12, Exploring Ng MIP Neisseria gonorrhoeae Macrophage Infectivity Potentiator) and Ng OMPA (Neisseria gonorrhoeae Outer Membrane Protein A) as novel candidates to fight gonococcal infection due to resistant or multi drug resistant gonococci Istituto Superiore di Sanita' Infectious Diseases and Microbiology 12, ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROTICS Lombardia AIDS and Related Research 12, Malignancy and invasiveness molecular determinants in oro pharyngeal squamous cell carcinomas. REGINA ELENA Oncology 1 Basic 12, CREATION OF A NATIONAL NETWORK FOR THE DIAGNOSIS OF MALIGNANT LYMPHOMAS Emilia Romagna Oncology 2 12, Development and assesment of a regional palliative care network. The Ligurian Palliative Care Demonstration Project. IRCCS AOU San Martino IST (Genova) Healthcare Delivery and 12, EBV reactivation and CD8+ T cell responses in Multiple Sclerosis SANTA LUCIA Immunology 12, Home based palliative care for people with severe multiple sclerosis: Developmental and pilot phases of the Palliative Network for Severely Affected Adults with MS in Italy (PeNSAMI) study CARLO BESTA Brain Disorders and 12, Pagina 66 di 142

67 Development of a novel lubricating gel containing antimicrobial loaded nanoparticles to prevent urinary catheter associated infections particularly in patients with neurogenic bladder requiring long term catheterization. SANTA LUCIA Infectious Diseases and Microbiology 12, NICAL AND PHARMACOLOGICAL EVALUATION OF TRABECTEDIN (T) IN BRCA MUTATION CARRIER AND BRCANESS PHENOTYPE OVARIAN CANCER PATIENTS ISTITUTO TUMORI MILANO Oncology 2 12, FRACTURE UNIT MULTIREGIONAL EXPERIMENTATION PROJECT (FRAME Project) Toscana Healthcare Delivery and 12, Mechanisms of mood control by inflammatory cytokines in Multiple Sclerosis. SANTA LUCIA Brain Disorders and 12, Evaluation of the effectiveness of ADL based exercises Vs point to point reaching tasks in robot mediated therapy of the upper limb for sub acute stroke patients SAN RAFFAELE PISANA Emerging Technologies and Training in s 12, ENDOGENOUS OUABAIN IS IMPLICATED IN ACUTE KIDNEY INJURY IN CARDIAC SURGERY AND CRITICALLY ILL PATIENTS: A METABOLOMIC STUDY Digestive, Kidney and Urological Systems 12, Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus Istituto Superiore di Sanita' Immunology 12, Predictive value of FDG PET/CT Metabolic Tumour Volume in patients treated with neoadjuvant chemoradiation therapy for locally advanced rectal cancer Liguria Oncology 2 12, TOOLS FOR THE IMPROVEMENT OF ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES: AN INTERVENTION STUDY DON GNOCCHI Risk, Prevention and Health Behavior 12, Identification of clinical and genetic factors for personalized opioid therapy of cancer pain ISTITUTO TUMORI MILANO Oncology 2 12, Pagina 67 di 142

68 Validation of a new algorithm for HPV status assessment in head and neck carcinoma ISTITUTO TUMORI MILANO Oncology 2 12, WAC Project (Web Based Asthma Control) evaluation of the utility of a web based electronic health diary to improve control of moderate severe asthma Toscana Cardiovascular and 12, Co Amplification of the ERBB2 and RARA genes in breast cancer: a potential target for retinoid based therapy MAUGERI Oncology 2 12, ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES SDN Genes, Genomes and Genetics 12, Advanced diagnostics and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD). NEUROLESI Musculoskeletal, Oral and Skin Sciences 12, RELATIOSHIPS BETWEEN VASOACTIVE MEDIATORS AND HEMODYNAMIC ALTERATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS. Toscana Brain Disorders and 12, Exposure to occupational carcinogens and pathogenetic mechanisms in sinonasal adenocarcinomas Piemonte Oncology 1 Basic 12, Multiple gene analysis in bronchoscopic specimens from patients with advanced non small cell lung cancer I.E.O. Oncology 2 12, Effects of high intensity robot assisted training in hand function recovery and ADL independence after stroke: a multicentre randomized controlled single blind trial SAN RAFFAELE PISANA Brain Disorders and 12, MOLECULAR EVENTS IN MELANOMA PROGRESSION: REGULATION OF AP 2 TARGET GENES AND INVOLVEMENT IN TUMOR GROWTH AND METASTASIS. Piemonte Oncology 2 12, Exploring the role of drusen in the retinas as possible markers for the Alzheimer s disease pathology: a multidisciplinary approach. Istituto Superiore di Sanita' Brain Disorders and 12, Pagina 68 di 142

69 Inflammation and cancer: relevance of chemokines in myeloid cells recruitment, activation and cross talk with NK cells in tumor biology Understanding the adaptive immune response defects of WHIM syndrome patients HUMANITAS Immunology 12, HUMANITAS Immunology 12, Biological aging in dilated cardiomyopathy and chronic obstructive pulmonary disease Veneto Cardiovascular and 12, A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATIONS IN ATM, OCT and MATE GENES IN THE GLYCAEMIC RESPONSE TO METFORMIN IN DRUG NAÏVE TYPE 2 DIABETIC PATIENTS AUXOLOGICO Genes, Genomes and Genetics 12, Characterization of new molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian cancers CROB Oncology 2 12, GADD45beta cell permeable inhibitor peptide against cerebral ischemia Lombardia Brain Disorders and 12, Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Brain Disorders and 12, MicroRNA replacement therapy for the treatment of Neuroblastoma Liguria Oncology 2 12, Nanotecnology based drug delivery : new generation nanovector for drug delivery in human bone diseases. GALEAZZI Musculoskeletal, Oral and Skin Sciences 12, ROLE OF PERFUSION COMPUTED TOMOGRAPHY(PCT)AND VASCULAR ENDOTHELIAL GROWTH FACTOR A(VEGF A)SERUM LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS(HGG):NEW METHODS OF MONITORING TREATMENT? NEUROMED Oncology 1 Basic 12, Pagina 69 di 142

70 Molecular and Functional Characterization of a Polycystin/Nephrocystin Complex Digestive, Kidney and Urological Systems 12, Definition of the prognostic and biological roles of tissueassociated and soluble biomarkers in epithelial ovary cancer exploiting well characterized retrospective and prospective clinical series of samples ISTITUTO TUMORI MILANO Oncology 2 12, Physiological effects of extracellular guanosine triphosphate (GTP) on renal cells and water transport Abruzzo Cell Biology 12, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS Lombardia Interdisciplinary Molecular Sciences and Training 12, A proteomic and lipidomic approach to discover diagnostic and predictive markers of lung cancer. Emilia Romagna Oncology 2 12, Predictive biomarkers of melanoma progression and clinical response to chemo immunotherapeutic therapies using new medical imaging approaches SAN GALLICANO Oncology 2 12, Relevance of host factors in the pathogenesis of HCVrelated lymphoproliferative disorders Toscana Oncology 1 Basic 12, Whole transcriptome changes induced by vaccineelicited immune responses in melanoma patients: providing the rationale for the development of dynamic antigen updating of dendritic cell vaccines Emilia Romagna Immunology 12, Immunogenic cell death as predictive and real time marker of response to EGFR targeted therapy in CRC patients I.E.O. Oncology 2 12, Mast cells translate external challenges into immune regulation affecting colitis and colorectal cancer. ISTITUTO TUMORI MILANO Immunology 12, Nociceptin/Orphanin FQ as a biomarker for Parkinson s disease Friuli Venezia Giulia Brain Disorders and 12, Pagina 70 di 142

71 Functional studies of deregulated micrornas in Sezary Syndrome ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 1 Basic 12, Efficacy of nicotine dependence pharmacotherapy based on individual pharmacokinetic profile and identification of pharmacogenetic determinants of drug response Toscana Brain Disorders and 12, NICAL IMPACT OF TISSUE AND CIRCULATING MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF THYROID CANCER Toscana Oncology 2 12, ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES: A MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS MONDINO Brain Disorders and 12, Role of stromal cells in lymphoma mediated immunosuppression: a novel target for the treatment. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 12, Parkinson's Disease: a new approach to motor and cognitive neurorehabilitation FATEBENEFRATELLI Brain Disorders and 12, Integrated risk assessment for food safety emerging risks in sustainable farming systems (IRASF) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 12, STem cells Mobilization in Acute Myocardial Infarction Outcome Trial (STEM AMI OUTCOME Trial): efficacy and functional substudies Lombardia Cardiovascular and 12, Colorectal cancer: Vitamin D, VDR and beta Catenin expression study: from biological pathways to clinical prevention. I.E.O. Oncology Evaluation of chemotherapy induced cardiotoxicity utilizing cardiac byomarkers doppler echocardiography and Magnetic Resonance Imaging Lazio Brain Disorders and Pagina 71 di 142

72 CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF EPITHELIAL SKIN CANCERS MAUGERI Surgical Sciences, Biomedical Imaging, and Bioengineering CHRONIC KIDNEY DISEASE (CKD) AND CARDIOVASCULAR RISK. MOLECULAR MECHANISMS, NICAL IMPLICATIONS AND NEW PREVENTIVE STRATEGIES Lombardia Digestive, Kidney and Urological Systems LOGICAL BANK TO IDENTIFY MARKERS OF DISEASE ACTIVITY RELATED TO NICAL VARIABLES AND MODIFYING DRUGS IN MULTIPLE SCLEROSIS Emilia Romagna Brain Disorders and A randomized multicenter study to compare the efficacy of additional tumor debulking surgery versus chemotherapy (CT) alone for recurrent platinum(p) sensitive ovarian cancer (OC) PASCALE Oncology NICAL IMPACT OF CIRCULATING TUMOR CELLS AND MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF SOLID TUMORS Toscana Oncology Semicarbazide sensitive amine oxidases (SSAOs) and matrix degrading metalloproteases (MMPs): a multidisciplinary study of their possible contribution to cerebral amyloid angiopathy (CAA) in Alzheimer's disease. SAN RAFFAELE PISANA Brain Disorders and Sgk1: a novel regulator of genomic stability in human cancer Calabria Oncology 1 Basic Combined use of transcranial direct current stimulation and speech therapy to treat patients with aphasic stroke: short and long term effects on anomia MAUGERI Emerging Technologies and Training in s BDNF polymorphism, calprotectin and clinical phenotype in Rett syndrome Toscana Brain Disorders and Pagina 72 di 142

73 Functional and effective connectivity evaluation in drugresistant epileptic patients candidates to surgery.a new tool for identification of the seizure onset zone and prediction of memory and cognitive outcome. Toscana Brain Disorders and "Distribution of allelic polymorphism (TAAA)n in the Sex Hormone Binding Globulin (SHBG) gene in breast cancer patients with or without hormone therapy:relations with SHBG plasma levels and nutrictional factors". ONCOLOGICO DI BARI Genes, Genomes and Genetics Experimental models for investigation of interrelationship between CSCs/TICs and metastasis Emilia Romagna Oncology 1 Basic Cytoreduction and Hipec in the treatment of OvaRIaN cancer CHORINE StudyStage IIIC unresectable epithelial ovarian/tubal cancer with partial or complete response after 1st line neoadjuvant chemotherapy (3 Lombardia Oncology cycles CBDCA+Paclitaxel): a phase 3 pros The use of Nanoparticles in food technology: release assessment and development of analytical methods through selected case studies Istituto Zooprofilattico Sperimentale delle Venezie Bioengineering Sciences and Technologies Effects of conventional rehabilitation terapy and combined restorative interventions in patients with post stroke deficits of the upper limb S.CAMILLO Brain Disorders and Potential relevance of HLA G, gelatinases and herpes viruses as markers of tumor invasion and progression and their association with CT and MRI perfusion findings in patients with high grade glioma Emilia Romagna Brain Disorders and Internet addiction disorder in adolescents: identification of possible biological and personality markers Toscana Brain Disorders and Pagina 73 di 142

74 DEVELOPMENT IN ACUTE MYELOID LEUKEMIA PATIENTS OF A GENOMIC TEST BASED ON PROFILING OF APOPTOTIC MACHINERY AND OF mi RNA FOR REFINEMENT OF PROGNOSTIC RISK CLASSIFICATION AND TO GUIDE POST REMISSIONAL THERAPEUTIC STRATEGY Sicilia Oncology Development and evaluation of a reverse transcriptase Real Time PCR assay for the study of the presence of viable Toxoplasma gondii in vegetable and meat Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary Understanding the function of WRNIP1 in the maintenance of common fragile site stability and in lung cancer development Istituto Superiore di Sanita' Oncology 1 Basic Therapeutic strategies in refractory chronic daily headache: A multicenter, open, randomized, controlled trial. Istituto Scienze Neurologiche Emerging Technologies and Training in s User participation in payment of health treatments(copayement) Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of associated carcinogenic risk Istituto Superiore di Sanita' Oncology 1 Basic CIRCULATING ANTI TRANSGLUTAMINASE ANTIBODIES: A NOVEL MARKER OF RECURRENT ABORTION AND A KEY INFLUENCER OF NEO ANGIOGENESIS Molise Cell Biology Hydrogen sulphide (H2S) as a novel player in endothelial dysfunction associated to hypertension SAN RAFFAELE PISANA Cardiovascular and COMBINATORIAL IMMUNOLOGICAL AND NANOPARTICLE MEDIATED TARGETING OF THE EARLY STEPS OF THE METASTATIC DISEASE C.R.O. AVIANO Oncology 1 Basic Fatigue relief in Multiple Sclerosis by transcranial Direct Current neurostimulation (tdcs). [FaMuSne] SAN RAFFAELE PISANA Brain Disorders and Pagina 74 di 142

75 Custom made devices for bone regenerative medicine. RIZZOLI Musculoskeletal, Oral and Skin Sciences Emerging contaminants in the feed food chain: integrated models to support risk analysis Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary Characterization and validation of new prognostic markers in high grade ovarian cancer. C.R.O. AVIANO Oncology 1 Basic In vivo modeling glioblastoma to identify new therapeutic targets and assay a novel oncolytic therapy IRCCS AOU San Martino IST (Genova) Oncology 1 Basic Biomaterial functionalization to improve biofunctionality and osteointegration of medical devices for healthy and osteopenic bone. RIZZOLI Musculoskeletal, Oral and Skin Sciences The response to intestinal microbiota in peripheral blood and gut mucosa from patients with Crohn's Disease: from the definition of immune profiles to the development of induced pluripotent stem cells for pharmacologic studies. BURLO GAROFALO Digestive, Kidney and Urological Systems Role of host pathogen interplay in genital cancer pathogenesis: gene mutations and nucleotide polymorphisms as determinants of cancer susceptibility and response to therapy PASCALE Oncology 1 Basic Identification and pathways to care of children with complex or chronic health conditions and special health care needs Emilia Romagna Healthcare Delivery and Chemical protection against ionizing radiation in subjects undergoing radiodiagnostic procedures: analysis of the role of natural compounds in a translational research plan Istituto Superiore di Sanita' Risk, Prevention and Health Behavior NICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT RIZZOLI Musculoskeletal, Oral and Skin Sciences Pagina 75 di 142

76 IMmunity, Inflammation and Carotid ATherosclerosis: the IMICAT study MONZINO Vascular and Hematology Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology SAN RAFFAELE PISANA Brain Disorders and MOLECULAR AND FUNCTIONAL PROFILES OF NON SELF SUFFICIENCY ELDERLY:FROM DIAGNOSIS TO CARE MODELS Calabria Healthcare Delivery and and biological studies on the increased thyroid cancer incidence in the volcanic area of Sicily. Sicilia Oncology Non cancer (atherosclerotic, neurocognitive, reproductive) health effects of chronic low dose radiation exposure in cardiac catheterization lab workers (the Healthy Cath Lab Study) Sicilia Cardiovascular and A randomized intervention study to assess the effect of the Mediterranean Diet on plasma fatty acid profile. MONZINO Cardiovascular and Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in the Italian NHS Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and Predictive value of heart rate viariability in fetuses of high risk pregnancies. Development of a new method for accurate and rapid signal detection and analysis. Friuli Venezia Giulia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS Surgical Sciences, Biomedical Imaging, and Bioengineering Proteomics of benign and malignant parathyroid tumors: identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer Toscana Oncology 1 Basic Pagina 76 di 142

77 ROLE OF HOST AND VIRAL FACTORS ON THE EXPERIMENTAL INFECTIONS OF CYNOMOLGUS MACAQUES WITH SIMIAN OR SIMIAN HUMAN IMMUNODEFICIENCY VIRUS. Istituto Superiore di Sanita' AIDS and Related Research FROM HUMAN TO CANINE. SERUM TUMOUR MARKERS EXPRESSION IN MAMMARY CANCER: NEW PERSPECTIVE IN VETERINARY ONCOLOGY? Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary Role of mir 155 in FLT3 ITD mutated acute myeloid leukemia: studies of network, signalling and silencing. Sicilia Oncology 1 Basic Circulating Tumour Cells (CTC) and Cancer Stem Cells from human prostate: new device and tools for markers detection,cell isolation and their ex vivo expansion as three dimensional structures Lazio Digestive, Kidney and Urological Systems Explaining coronary heart disease mortality trend in Italy between 2000 and 2010 and forecasting health and economic scenarios for prevention strategies Istituto Superiore di Sanita' Population Sciences and Epidemiology A perspective study in HIV infected individuals to determine the impact of HAART and the role of specific antiviral immune responses on the establishment and maintenance of virus reservoirs, which are key for chronic virus persistence and disease progress SAN GALLICANO AIDS and Related Research Splicing variants of L1CAM in human cancer cells: functional relevance in modulating NK cell mediated antitumor activity. HUMANITAS Immunology Mechanisms and actions of Regorafenib, a new hepatoma (HCC) therapy DE BELLIS Oncology Whole exome resequencing in familial Neural Tube Defects GASLINI Genes, Genomes and Genetics Biological and biomechanical experimentation using a new vetro ceramic scaffold for bone regeneration in order to evaluate surgical and pharmacological treatments before testing on the patient. Piemonte Bioengineering Sciences and Technologies Pagina 77 di 142

78 Multiplex Ligation Probe Amplification (MLPA) analysis, 5p 13.2 Loss Of Heterozygosity (LOH),CA SSR1 EGFR microsatellite analysis and NIPBL Illumina Solexa sequencing in Thymic Epithelial Tumors and Squamous Cell Lung Carcinomas metastatic to the medias REGINA ELENA Oncology 1 Basic Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) Veneto Vascular and Hematology Analysis of macrophage and neutrophil subpopulations in the vascular remodelling occurring in HCC genesis and progression. Implications for early diagnosis, prognosis and therapy. HUMANITAS Oncology Continuity of mental disorders from childhood to early adulthood in Emilia Romagna and Piemonte: comparison with the Danish population Emilia Romagna Risk, Prevention and Health Behavior New candidate gene for hemiplegic migraine and episodic ataxia Lazio Genes, Genomes and Genetics Papillomavirus (HPV) genital infection in men: genotypes prevalence, presence of viral transcripts and association with genital clinical signs and sperm function Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13, Characterization of melanoma cells from primary and metastatic human melanoma in culture: prognostic and therapeutic implications Emilia Romagna Oncology 1 Basic 13, Innovative tools to predict the response to chemotherapy in cancer patients Oncology 1 Basic 13, PLERIXAFOR ADMINISTRATION AND MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS TO PROMOTE NEO VASCULARIZATION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA Cardiovascular and 13, Fertility preservation in young Oncological female patients REGINA ELENA Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13, Pagina 78 di 142

79 Priority setting in healthcare: the case of home care program in Tuscany Region for heart failure patients Toscana Healthcare Delivery and 13, Biological markers in bone metastases from prostate cancer: evaluation of live and apoptotic Circulating (CTC) and Disseminated tumor cells (DTC) in patients undergoing chemotherapy and correlation with tumor response and bone turnover rate. I. O. V. Oncology 2 13, GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO Genes, Genomes and Genetics 13, Patient participation in Change of Shift Procedures. The Implementation of the Bedside handover for the improvement of nursing quality ARCISPEDALE Healthcare Delivery and 13, Health Technology assessment on mesenchymal stem cells and growth factors in orthopedics and traumatology Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 13, Diurnal and Inter visit IOP fluctuations: a risk factor for conversion from ocular hypertension to primary openangle glaucoma? FATEBENEFRATELLI Risk, Prevention and Health Behavior 13, GENETIC AND NEUROLOGICAL INFLUENCES ON RISK TAKING PROPENSITY Istituto Superiore di Sanita' Population Sciences and Epidemiology 13, Vg9Vd2 T cells in combination with zoledronate as novel immunotherapeutic approach for human neuroblastoma GASLINI Oncology 2 13, Pathogenic mechanisms and animal models of hereditary neurodegenerative cerebellar diseases due to mitochondrial defects. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Genes, Genomes and Genetics 13, THE EFFECTIVENESS OF STRUCTURED PSYCHOEDUCATION FOR RELAPSE PREVENTION IN BIPOLAR DISORDERS FATEBENEFRATELLI Biobehavioral and Behavioral Processes 13, Comparative efficiency and risk assessment of grafting human gabaergic neural precursors from different sources in experimental models of Huntington disease. SAN MATTEO Brain Disorders and 13, Pagina 79 di 142

80 RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY MAUGERI Cardiovascular and 13, Metabolomic analysis of primary immunodeficiency and its application to a low cost neonatal screening program. Assessment and longitudinal monitoring of thymic output and immune status in the 22q11.2 deletion syndrome Toscana Immunology 13, Toscana Immunology 13, The role of Integrin alpha5/beta1 as a potential I. O. V. Oncology 2 therapeutic target in bone metastasis: a translational study 13, A translational study to identify and validate predictive molecular and cytogenetic biomarkers of durable complete response to trastuzumab containing chemotherapy for HER2 positive metastatic or locally advanced breast cancer HUMANITAS Oncology 2 13, Adult Niemann Pick type C disease as a model of tauopathy. Implications for the pathogenesis of Alzheimer disease. CARLO BESTA Brain Disorders and 13, PTPRJ and EGFR as targets for innovative molecular therapies of lung cancer Calabria Oncology 2 13, Role of the mitogen activated protein kinase ERK5 in chronic liver injury and hepatocellular carcinoma Toscana Digestive, Kidney and Urological Systems 13, Analysis of the clinical heterogeneity on a wide cohort of Rett patient through a biochemical and molecular approach AUXOLOGICO Genes, Genomes and Genetics 13, Impact of screening on survival in breast cancer patients: the role of tumor biology Toscana Population Sciences and Epidemiology 13, Pharmacoepidemiology, pharmacosurveillance and identification of predictive factors of oxaliplatin neurotoxicity in colorectal cancer: development and validation of a prognostic score Toscana Oncology 2 13, Pagina 80 di 142

81 Study of a method of calculation of the optimum radionuclide activity in radioimmunotherapy of tumors based on the reduction of the target mass Veneto Oncology 2 13, Proteomic salivary analysis and a mathematical model for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis. Toscana Musculoskeletal, Oral and Skin Sciences 13, Antiplatelet aspirin therapy and megakaryocytic gene expression: molecular and cellular mechanisms underlying "drug resistance" in preventing cardiovascular events. Istituto Superiore di Sanita' Vascular and Hematology 13, ROLE OF MATERNAL INTRAPARTUM ANTITIC PROPHYLAXIS ON NEONATAL GUT MICROTA FLORA AND ONSET OF LATER ALLERGY RELATED DISEASES. Lombardia Infectious Diseases and Microbiology 13, Pathogenesis of idiopathic thromboembolism: role of antiendothelial auto antibodies and endothelial cell dysfunctions. HUMANITAS Immunology 13, Identification and validation of co morbidity scores and analysis of their impact on the fitness for treatment in patients with solid and haematological tumours HUMANITAS Healthcare Delivery and 13, Multidisciplinary study of the motor function in obese subjects with Prader Willi syndrome: from molecular control to muscular performance. AUXOLOGICO Musculoskeletal, Oral and Skin Sciences 13, Metal ions levels in symptomatic and asymptomatic patients with metal on metal replacement Lombardia Risk, Prevention and Health Behavior 13, THE ROLE OF ALCOHOL USE IN PATIENTS WITH A FIRST EPILEPTIC SEIZURE IN DIFFERENT POPULATIONS. Piemonte Population Sciences and Epidemiology 13, Identification and characterization of new SHOX related and SHOX unrelated mutations by Next Generation Sequencing analysis and pharmacogenomics evaluation of rhgh treatment Emilia Romagna Genes, Genomes and Genetics 13, Pagina 81 di 142

82 Metabolic syndrome and liver cancer: surveillance program on large population in Veneto Veneto Risk, Prevention and Health Behavior 13, Evaluation of Neuroprotection with NGF Mimetic Compounds Using Molecular Microimaging of Apoptotic Post ischemic Neuronal Death Toscana Brain Disorders and 13, Dietary patterns in midlife and occurrence of Alzheimer disease in old ages Lombardia Population Sciences and Epidemiology 13, Long term Legionella control in hospital hot water distribution systems by water treatment with natural terpenoid based products: assessment of their antimicrobial and toxicological activities in batch, pilotplant and real scale conditions. Istituto Superiore di Sanita' Infectious Diseases and Microbiology 13, Mitochondrial dysfunction in ALS : a study of novel molecular partners as targets for therapeutic interventions Emilia Romagna Molecular, Cellular, and Developmental 13, Gender and age related differences in motility and permeability responses in human colon: role of estrogens. DE BELLIS Digestive, Kidney and Urological Systems Modulation of mir 221 and mir 222 in skeletal muscle cells: impact on muscle physiology and pathology Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences Molecular modeling and functional analyses of EGFR for the selection of lung cancer patients eligible for targeted therapy with receptor kinase inhibitors ISTITUTO TUMORI MILANO Oncology Antiprotons vs photons: a new hypothesis for radiotherapy ONCOLOGICO DI BARI Oncology STUDIES OF NEOPLASTIC PREVALENCE IN SINATHROPUS ANIMALS LIVING ON NATIONAL INTEREST SITES(SIN)IN CAMPANIA REGION AND EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENTAL ONCOLOGICAL RISKS Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary Pagina 82 di 142

83 Glia immune crosstalk in multiple sclerosis Molecular, Cellular, and Developmental Ovarian serous carcinoma:identification of prognostic and predictive markers and risk assessment. Calabria Oncology 1 Basic Integrated approach to investigate the effect of environmental pollution on reproductive outcomes Emilia Romagna Genes, Genomes and Genetics Circulating microrna as potential biomarkers of prediabetic and diabetic complications Veneto Cardiovascular and A therapeutic approach to Fragile X syndrome based on the pharmacology of Rho GTPases Istituto Superiore di Sanita' Brain Disorders and Sensitizing cancer stem cells driven glioma to radiotherapy via pharmacological inhibition of Ataxia Telangiectasia Mutated protein IRCCS AOU San Martino IST (Genova) Oncology Innate immune signaling networks in intestinal epithelial cells and their role in shaping T cell responses in inflammatory bowel diseases Istituto Superiore di Sanita' Immunology Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health Istituto Superiore di Sanita' Oncology CDKL5 variant of Rett s syndrome: clinical phenotype and effects of mutations on the development of the central nervous system in view of future therapeutic approaches Istituto Scienze Neurologiche Brain Disorders and New treatments for alleviation of neuropathy and regenerative impairment in diabetes. MULTIMEDICA Cardiovascular and Post Transplant Hematopoiesis: a model to understand the mechanisms of hematopoietic stem cells (HSC) aging and the interactions between HSC and microenvironment. IRCCS AOU San Martino IST (Genova) Vascular and Hematology Pagina 83 di 142

84 Development of bispecific antibodies for therapeutic approaches against HIV infection. Istituto Superiore di Sanita' AIDS and Related Research Studies of the pathogenic mechanisms and zoonotic role of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary Genetic and epigenetic mechanisms in addiction: An opportunity for development of new pharmacotherapeutic strategies for alcoholism. FATEBENEFRATELLI Brain Disorders and How to improve and rationalize targeted head and neck squamous cell carcinoma treatments ISTITUTO TUMORI MILANO Oncology The mevalonate (Mev) pathway as a common metabolic target to modulate the susceptibility of Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) tumor cells to chemotherapy, environmental prosurvival signals, and immune recognition by Vgamma9Vde Piemonte Oncology Identification of novel targets in thyroid carcinogenesis by sirna based loss of function screening ISTITUTO TUMORI MILANO Oncology 1 Basic Monitoring allogeneic Hematopoietic stem cells transplant patients for viral load and CMV drug resistance genotypes GASLINI Infectious Diseases and Microbiology MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Cardiovascular and Development and progression of breast cancer: when EMT meets stemness C.R.O. AVIANO Oncology 1 Basic Personalising curative treatment decision for locally advanced head and neck cancer through identification of biological markers ISTITUTO TUMORI MILANO Oncology Analysis of the effect of chemotherapeutic treatment on trastuzumab cytotoxic activity ISTITUTO TUMORI MILANO Oncology Pagina 84 di 142

85 Enhancing Transparency of Reporting of Systematic Reviews to Improve Health Care Emilia Romagna Healthcare Delivery and CHARACTERIZATION OF NEW MOLECULAR MARKERS OF NEUROINFLAMMATION ASSOCIATED WITH ALZHEIMER'S DISEASE Sicilia Molecular, Cellular, and Developmental Opportunistic virus infections in transplant recipients and patients with chronic inflammatory diseases treated with biological immunosuppressive drugs SAN MATTEO Immunology Studies on the cardiovascular effects of mandibular stretching and on their potential application in the treatment of arterial hypertension Toscana Cardiovascular and USE OF NEXT GENERATION SEQUENCING IN NICS: EVALUATION OF MODELS OF EARLY OR COMPREHENSIVE DIAGNOSIS IN A REGIONAL ASSET Liguria Genes, Genomes and Genetics Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost benefit analysis. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with difficult diagnosis: Implications for Disease Definition, Diagnosis, and Treatment. ISTITUTO DERMOPATICO DELL'IMMACOLATA Population Sciences and Epidemiology Effectiveness of multidisciplinary clinical approach and psychological treatment on enhanced recovery after surgery in patients with Inflammatory Bowel Diseases (IBD) Toscana Risk, Prevention and Health Behavior Response Evaluation Criteria in Solid Tumors: a comparative study between Imaging and Biomolecular indices Sicilia Oncology Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Brain Disorders and Pagina 85 di 142

86 Brain complexity and complexity matching for enhancing the positive effects of environmental enrichment on psychopathology Istituto Superiore di Sanita' Integrative, Functional, and Cognitive PREDICTION OF AWAKENING FROM ACUTE COMA USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS AND PAIN RELATED FUNCTIONAL BRAIN MAGNETIC RESONANCE. Veneto Brain Disorders and Long term efficacy of non pharmacological computer assisted treatment in Alzheimer s Disease and MCI (Mild Cognitive Impairment) patient Lombardia Brain Disorders and AN ALTERNATIVE APPROACH TO NICAL MANAGEMENT OF GESTATIONAL DIABETES Lombardia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Long term cancer survivors: a comparison between treatments and disease free persons and persons with active disease under therapeutic control. C.R.O. AVIANO Oncology Randomized Trial Of Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy In Peritoneal Carcinomatosis Arising From Colorectal Cancer ARCISPEDALE Oncology Anaplastic lymphoma kinase (ALK) gene status assessment to improve treatment of pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO Oncology governance and occupational well being: a new organizational approach to healthcare performance Emilia Romagna Healthcare Delivery and HIV patient s adherence: a study of predictive factors Lombardia AIDS and Related Research The effectiveness of music therapy on depression and on Quality of Life in patients with Amyotrophic Lateral Sclerosis and in post Stroke condition. MAUGERI Healthcare Delivery and Pagina 86 di 142

87 NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA. NEUROLESI Molecular, Cellular, and Developmental Role of glucocorticoid induced leucine zipper (GILZ) in autoimmunity Istituto Superiore di Sanita' Immunology BiS trial: randomized controlled trial on biologic vs synthetic mesh for the treatment of large defect congenital diaphragmatic hernia. OSPEDALE BAMBINO GESU' Surgical Sciences, Biomedical Imaging, and Bioengineering Evaluation of AIFA monitored antineoplastic drugs in advanced cancer patients in the last months of life in Regione Emilia Romagna Emilia Romagna Healthcare Delivery and New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering Improving quality of research: a complex intervention trial Emilia Romagna Healthcare Delivery and Combined molecular and functional studies to identify novel targets for neuroprotection against brain and spinal cord damage: from bench to bedside. Toscana Brain Disorders and IDENTIFICATION OF NEW GENETIC, PROTEIC AND METABOLIC MARKERS TO DISTINGUISH BENIGN FROM MALIGNANT THYROID CELLS. Toscana Genes, Genomes and Genetics VENOUS THROMBOEMBOLISM IN FAMILIES WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE NICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY INVESTIGATION OF INDIVIDUALS WITH INHERITED THROM Lazio Population Sciences and Epidemiology Pagina 87 di 142

88 NICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG FIVE IMPORTANT ACUTE HOSPITALS Toscana Risk, Prevention and Health Behavior Policystic ovary syndrome and nitric oxide. Effects of the treatment with N acetylcysteine Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences High detection of chronic kidney disease (CKD) in general population by combination of estimated glomerular filtration rate (GFR) and microalbuminuria Puglia Digestive, Kidney and Urological Systems Autism Epilepsy: endophenotypic characterization and correlation with astrocyte neuron interaction defects. STELLA MARIS Biobehavioral and Behavioral Processes Complex Interventions at Work: comparative analysis of case studies on implementation of process oriented organization of hospital care in community and teaching hospitals Emilia Romagna Healthcare Delivery and 14, Epigenetic profiles of prognostic markers and therapeutic targets in non small cell lung cancer Emilia Romagna Oncology 1 Basic 14, HYPOPLASTIC LEFT HEART SYNDROME (HLHS): FROM DISCOVERY OF GENETIC BASIS TO MOLECULAR CLASSIFICATION FOR THERAPEUTIC STRATEGIES Lombardia Genes, Genomes and Genetics 14, Gio why not? A perspective observational study to improve early diagnosis of andrologic pathologies in young people. Risk, Prevention and Health Behavior 14, Pancreatic Islet Cell Transplantation for Treatment of Type 1 Diabetes ONCOLOGICO DI BARI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14, Identification of new molecular targets in preclinical models of cholangiocarcinoma and in tumor derived xenopatients Piemonte Oncology 2 14, Pagina 88 di 142

89 Functional BRAIN CHIP INTEGRATOR (fbci): A pilot study to implement novel rehabilitation strategies through neurochips technology in patients with disorders of consciousness. CARLO BESTA Brain Disorders and 14, Epidemiology of primary biliary cirrhosis in Lombardia: a validation and geographical clustering study HUMANITAS Population Sciences and Epidemiology 14, Titanium based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO Musculoskeletal, Oral and Skin Sciences 14, Ring annuloplasty versus Suture repair for the treatment of Not Severe Tricuspid Regurgitation in patients undergoing surgery for Mitral Valve disease: a Prospective, Randomized Study. Surgical Sciences, Biomedical Imaging, and Bioengineering 14, Electroclinical and genetic characterization of Epilepsy in a population of patients with ring 20 chromosome syndrome. EEG fmri study and comparison with a group of patients with frontal lobe epilepsies (genetic and structural etiologies) Lombardia Brain Disorders and 14, HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy. Lombardia AIDS and Related Research 14, Heart failure specialist nurse services (HFSN) Marche Healthcare Delivery and 14, Peri operative stress in cardiac surgery: psycho social aspects, genetic predisposition and biohumoral characterization Toscana Cardiovascular and 14, What is better for the therapy of chronic inflammatory demyelinating polyneuropathy? Intravenous Immunoglobulins versus steroids and intravenous immunoglobulins versus sub cutaneous immunoglobulins: a nationwide cost utility study. Piemonte Brain Disorders and 14, Metabolic syndrome in the etiology and prognosis of hepatocellular carcinoma: a multicentre study. PASCALE Oncology 2 14, Pagina 89 di 142

90 New radiotherapic technologies(t): role of hypofractionated(h) Intensity Modulated Image Guided Radiotherapy in Locally Advanced Non Small Cell Lung cancer (Stage IIIA IIIB) Emilia Romagna Oncology 2 14, Evaluation of neuroendocrine derangements after severe acquired brain injuries: influence on clinical progression and functional recovery during rehabilitation Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14, Exploring the role of the HIV integrase inhibitor Raltegravir as a treatment of Secondary Progressive Multiple Sclerosis. Istituto Superiore di Sanita' Brain Disorders and 14, Interactive mapping of pathways and targets in renal cancers ISTITUTO TUMORI MILANO Oncology 2 14, Possibility to calculate the 131I activity based on the desired thyroid mass reduction in the radionuclide therapy of Graves' disease Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14, THERAPEUTIC DEVICE OF AREA FOR ADOLESCENCE WITH SEVERE PSYCHIATRIC DISORDERS. PROSPECTIVE STUDY ON EFFICACY. Lombardia Risk, Prevention and Health Behavior 14, Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Population Sciences and Epidemiology 14, Improving surgical treatment of traumatic nerve injuries by artificial nerve guides: a benefit for the patient and the community Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering 14, Individual and social effects of a sensitisation campaign on headache Lazio Healthcare Delivery and 14, The effect of moderate aerobic activity (fitwalking) on the metabolic and cardiovascular complications induced by antiretroviral therapy in patients with HIV infection AIDS and Related Research 14, Pagina 90 di 142

91 Neuropsychological, neuropshysiological and neuroimaging markers of progression in prodromal Alzheimer disease (AD): an interdisciplinary approach to the early detection of AD patients SAN RAFFAELE PISANA Biology of Development and Aging 14, UNMET NEEDS, QUALITY OF LIFE AND FAMILY BURDEN AMONG ICHTHYOSIS PATIENTS ISTITUTO DERMOPATICO DELL'IMMACOLATA Healthcare Delivery and 14, Integrating ehealth technologies for Patient and General Practitioner Empowerment Lazio Healthcare Delivery and 14, Risk benefit assessment of cardiovascular drug use in elderly and very old patients affected by cardiovascular disease: a multicentre pharmaco epidemiological study Lazio Healthcare Delivery and 14, Effect of chemotherapy on ovarian reserve oocytes and role of p63 Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14, A multidisciplinary approach to study Frontotemporal lobar degeneration FATEBENEFRATELLI Genes, Genomes and Genetics 14, GENETIC MODULATION OF COELIAC DISEASE CASA SOLLIEVO SOFFERENZA Digestive, Kidney and Urological Systems 14, MZN, a new natural herbal compound to combat HIV infection AIDS and Related Research 14, Identification of novel biomarkers for Renal Cell Carcinoma early diagnosis by peptidome and exosome analysis Puglia Oncology 2 14, Involvement of mutant p53 gain of function in tumor microenvironment REGINA ELENA Oncology 1 Basic 14, ROLE OF INFLAMMATION/IMMUNITY IN ATHEROSCLEROSIS: ANALYSIS OF POTENTIAL NOVEL MORPHOLOGIC AND/OR CHEMICAL MARKERS OF PLAQUE PROGRESSION/STABILIZATION SAN RAFFAELE PISANA Vascular and Hematology 14, Pagina 91 di 142

92 Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular indicators for clinical/disease staging and vaccine efficacy Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 14, Influence of metabolic factors on inflammation of colorectal mucosa in colorectal cancer risk assessment Emilia Romagna Oncology 2 14, The role of C1 (Chloride channel 1) in the tumorigenicity of glioblastoma cancer stem cells I.E.O. Oncology 1 Basic 14, Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention of Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia Romagna Oncology 2 14, Growth and oncolytic properties of Influenza A viruses in human pancreatic tumour cells and animal models Istituto Zooprofilattico Sperimentale delle Venezie Infectious Diseases and Microbiology 14, From sarcoma genetics and genomics to novel diagnostic and therapeutic strategies: a deep sequencing approach C.R.O. AVIANO Oncology 1 Basic 14, Advanced personal and environmental teledosimetry system Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 14, Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Integrative, Functional, and Cognitive 14, Application of new PET tracers for early imaging of radiation induced lung fibrosis in a mouse model Toscana Oncology 2 14, Novel assays for the diagnosis of scleroderma Marche Immunology 14, Characterization of HIV related mechanisms involved in the development of Burkitt s lymphoma Emilia Romagna AIDS and Related Research 14, Pagina 92 di 142

93 DEVELOPMENT OF A METHOD FOR NON INVASIVE ROUTINE PRENATAL DIAGNOSIS OF MONOGENIC DISORDERS USING CELL FREE DNA IN MATERNAL PLASMA Veneto Genes, Genomes and Genetics 14, An integrated pharmacogenetic approach to the optimization of adjuvant hormonal treatment of estrogen receptor positive breast cancer Toscana Oncology 2 14, Breast Cancer targeting through innovative drug delivery systems. IRCCS AOU San Martino IST (Genova) Oncology 2 14, Nd:YAG laser ablation for mininvasive endoscopic treatment of pancreatic neoplastic lesions: from animal model to human application Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering 14, Biomolecular Markers Involved in the Development of Hepatitis Virus Infections Associated Lymphomas: A Multicentric Case Control Study C.R.O. AVIANO Oncology 2 14, THE DOMOTIC GERIATRICS UNIT (DOMO_GER): AN INTELLIGENT SENSOR NETWORK FOR THE PREVENTION OF NEGATIVE OUTCOMES (DELIRIUM, FALLS, SUDDEN DEATH) IN HOSPITALIZED OLDER PATIENTS. Veneto Bioengineering Sciences and Technologies 14, Genome Remodeling in Luminal B and Ductal Triple Negative Breast Cancer Metastasis and Xenograft: Exome sequencing analysis for identification of driver pathways to overcome resistance I.E.O. Oncology 2 14, Mathematical modelling of mosquito borne diseases in Italy Istituto Superiore di Sanita' Population Sciences and Epidemiology 14, POST TRANSCRIPTIONAL REGULATION AND MITOCHONDRIAL LOCALIZATION OF BRCA1 IN HUMAN BREAST CANCER ONCOLOGICO DI BARI Oncology 1 Basic 14, Surveillance of the circulation of rotaviruses in the infantile population of Sicily in view of the introduction of rotavirus vaccination. Sicilia Infectious Diseases and Microbiology 14, Pagina 93 di 142

94 The use of a numerical model of the cardiovascular system to personalize and optimize cardiac resynchronization therapy (CRT) Lazio Cardiovascular and ROLE OF COLECALCIPHEROL IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT. Piemonte Brain Disorders and Personalized and optimized Road Map of effective integration between intensive medical treatment and secondary liver surgery in liver limited metastatic colorectal cancer (MCRC) through biomolecular characterization. Abruzzo Oncology Evaluation of the role of CD 133+/CD44+ colorectal TICs in patterns of metastatization and possible subsequent their clinical investigation ONCOLOGICO DI BARI Oncology Targeted resequencing of genomic regions by next generation sequencing technologies GASLINI Genes, Genomes and Genetics Identification of mirna based Therapeutical Targets in Gliomas by Integrated Genomic Analyses. CASA SOLLIEVO SOFFERENZA Oncology 1 Basic Early onset anorexia nervosa: the role of hyperactivity as predictor of outcome STELLA MARIS Risk, Prevention and Health Behavior Gender specific oncology: psychoncology s contribution to global care and rehabilitation of young adult male and female patients C.R.O. AVIANO Oncology C Choline PET/CT as Image Guide for radiotherapic treatment of prostate cancer recurrent lymphnodes Oncology Development, implementation and evaluation of a population based informational and educational package to improve knowledge on palliative care. A quasiexperimental study in the Liguria Region. IRCCS AOU San Martino IST (Genova) Healthcare Delivery and Telemonitoring in long term ventilator dependent patients: a multicenter randomized controlled study Toscana Cardiovascular and Pagina 94 di 142

95 SAFETY AND TOLERABILITY OF SECOND GENERATION ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROACTIVE/PROSPECTIVE PHARMACHOVIGILANCE STUDY MEDEA Biobehavioral and Behavioral Processes Early detection of lung cancer in asymptomatic high risk population by low dose CT scan and molecular markers. I.E.O. Oncology Title: Developing and Evaluation of innovative methods for detecting and trace infective pathogens in foods: molecular correlation with human cases Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary Sarcopenic obesity in hospitalized older persons: prevalence, associations with the geriatric syndrome of frailty, and effect on clinically relevant adverse health outcomes Emilia Romagna Biology of Development and Aging New perspectives in colorectal cancer for early diagnosis and therapy ONCOLOGICO DI BARI Oncology 1 Basic Use of Tranexamic acid in elective orthopaedic prosthetic surgery for preventing blood loss. Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering Role profiles and clinical competencies: a new approach for healthcare workforce Emilia Romagna Healthcare Delivery and NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana Cardiovascular and implementation of Adaptive Radiotherapy (ART) head and neck cancer. Evaluation of ART IMRT potential in reducing xerostomia and dysphagia. I. O. V. Oncology Multiple Chronic Conditions Prevalence, Care Management, Implications for Quality, and Health Costs Lombardia Healthcare Delivery and Pagina 95 di 142

96 RANDOMIZED CONTROLLED TRIAL OF MULTIDIMENSIONAL STIMULATION THERAPY IN PRODROMAL TO MODERATE STAGES OF ALZHEIMER'S DISEASE: NICAL, FUNCTIONAL MRI ASSESSMENT AND COST EFFECTIVENESS ANALYSIS. DON GNOCCHI Brain Disorders and Longitudinal, comprehensive, integrated study of outcome in patients with prolonged disorders of consciousness (DOC) MAUGERI Brain Disorders and CT scan evaluation of vertebral body derotation in adolescent idiopathic scoliosis surgery RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering How to evaluate Efficacy In the framework of costeffectiveness analysis for Growth Hormone (rhgh) Therapy in paediatric patients with Growth Hormone deficiency Piemonte Healthcare Delivery and Relationship between biomarkers, diastolic left ventricular recoil reserve measurement and ventriculararterial coupling to improve diagnosis and risk stratification in diastolic heart failure. Umbria Cardiovascular and The challenge of risk stratification in cardiac surgery: the ACEF PLUS to catch extreme conditions SAN DONATO Risk, Prevention and Health Behavior Establishing the early profile of chronic renal allograft dysfunction with functional magnetic resonance and contrast enhanced ultrasound Surgical Sciences, Biomedical Imaging, and Bioengineering EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF ERYTHRODERMIC CUTANEOUS T CELL LYMPHOMA: NICAL ACTIVITY, TOXICITIES, QUALITY OF LIFE IMPROVEMENT AND RESPONSE ASSOCIATED LOGICAL MARKERS Piemonte Oncology Prevalence of risk factors for cardiovascular and non viral hepatic diseases: an epidemiological study in two Italian populations Istituto Superiore di Sanita' Population Sciences and Epidemiology Pagina 96 di 142

97 Study of the interaction between polyomavirus JC (JCV) and stem cells Toscana Infectious Diseases and Microbiology Mechanisms of the antitumor activity of HIV protease inhibitors treatment in HIV negative patients affected by classical Kaposi s sarcoma or cervical intraepithelial neoplasia Istituto Superiore di Sanita' Oncology Producing ips cells: a biobank service for translational genetic research Liguria Genes, Genomes and Genetics ADJUSTING THE ENVIRONMENTAL CONTEXT TO IMPROVE SEROTONINERGIC ANTIDEPRESSANT EFFICACY Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes ARTEMIS (Augmented Realism in Teleconsulting and Education in MinimallyInvasive Surgery) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering TRANSMISSION OF SPORADIC CREUTZFELDT JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES Istituto Superiore di Sanita' Population Sciences and Epidemiology Role of oncogene induced senescence in thyroid carcinogenesis ISTITUTO TUMORI MILANO Oncology 1 Basic Viral respiratory tract infections in infants and young children: the IFNs/CD38/Ectonet axis as possible therapeutic target. Istituto Superiore di Sanita' Immunology Unraveling the fingerprint of a new subset of human tolerogenic dendritic cells Immunology Isolation and characterization of mesenchymal stem cells: therapeutic implications for cardiac disease Emilia Romagna Cardiovascular and Research of biomarkers in peripheral blood and tissue specimens for early diagnosis and prediction of therapy response in patients with colorectal cancer. Emilia Romagna Oncology Pagina 97 di 142

98 Danger associated molecular patterns: revealing the molecular signals dictating the communication between dying cells with the immune system Istituto Superiore di Sanita' Oncology Exposure to low arsenic concentrations via drinking water and health effects in 91 municipalities of the Lazio region, Italy Lazio Population Sciences and Epidemiology Identification of biomarkers for an early diagnosis of periprosthetic osteolysis Piemonte Musculoskeletal, Oral and Skin Sciences Abscisic acid, a new endogenous modulator of insulin release and glucose uptake: pre clinical studies of its use to improve the clinical assessment and design novel therapies for diabetes mellitus. IRCCS AOU San Martino IST (Genova) Endocrinology, Metabolism, Nutrition and Reproductive Sciences Ingestible device for the intragastric treatment of Helicobacter pylori infection Toscana Infectious Diseases and Microbiology A translational approach to hypertrophic cardiomyopathy: new therapeutic targets for a personalized drug therapy Toscana Cardiovascular and Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in tumor cells: breast cancer targeting and biodistribution Lombardia Bioengineering Sciences and Technologies Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Sicilia Risk, Prevention and Health Behavior Bio Molecular markers in the secondary prevention, diagnosis, prognosis and personalized therapy of hepatocellular carcinoma. Veneto Oncology strategy for developing rationale combinations of molecularly targeted agents in patients with non Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) HUMANITAS Oncology Pagina 98 di 142

99 Next generation approaches to identify novel pathophysiological mechanisms of coronary intra stent thrombosis and intra stent restenosis Toscana Cardiovascular and Ensuring the safety of human stem cells: evaluation of genomic stability and metrological assessment of regenerative medicine products Piemonte Genes, Genomes and Genetics Role of Copy Number Variations in determining the individual susceptibility to essential hypertension AUXOLOGICO Cardiovascular and Long term immune monitoring of patients with psoriasis or psoriatic arthritis treated with drugs targeting key mediators of the immune response to identify key parameters of therapeutic efficacy and/or disease progression SAN GALLICANO Immunology Association between Chronic Obstructive Pulmonary Disease and lung cancer: mechanisms of immune regulation Veneto Cardiovascular and Innovative analytical procedures and rapid diagnostic methods for the assessment of hygienic sanitary status of the fishery and mariculture production chains for the presence of emerging organic and inorganic micropollutants and emerging zoonotic pathoge Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary Development and exploitation of a platform able to produce antibody based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology ISTITUTO TUMORI MILANO Oncology Genome wide SNP identification for high resolution molecular genotyping of Listeria monocytogenes Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Infectious Diseases and Microbiology 15, Functional and viability impairment of cardiomyocytes in familial amyloid polyneuropathy Toscana Cardiovascular and 15, Pagina 99 di 142

100 Novel strategies in the pathogenesis, epidemiology and prognostic factors of papillary thyroid cancer Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15, Genetic predisposition to severe and recurrent infections: unravelling the pathogenic mechanisms of susceptibility EVALUATION OF HUMORAL AND CELLULAR REACTIVITY IN KIDNEY ALLOGRAFT PATIENTS: NEW TOOL TO TRIM THE IMMUNOSUPPRESIVE THERAPY IN ACCORDING TO THE AGE SAN MATTEO Immunology 15, Piemonte Immunology 15, A multidisciplinary approach to personalized medicine in CRC Sicilia Oncology 2 15, Effects of an educational intervention for reducing inappropriate prescribing in elderly exposed to polypharmacy in general practice Lombardia Healthcare Delivery and 15, Molecular subtype based follow up program in patients treated for early breast cancer Emilia Romagna Oncology 2 15, Calcium sensitizer agents for improving organs protection in transplants. Piemonte Surgical Sciences, Biomedical Imaging, and Bioengineering 15, Calcific arteriopathy in chronic kidney disease: genetic determinants, molecular biology and clinical markers Biology of Development and Aging 15, UPPER LIMB IMPAIRMENT IN CHARCOT MARIE TOOTH PATIENTS: MOTOR STRATEGIES, IMPACT ON QUALITY OF LIFE AND CORTICAL FUNCTIONAL REORGANIZATION DON GNOCCHI Musculoskeletal, Oral and Skin Sciences 15, Role of local synthesis and of systemic administration of Brain Derived Neurotrophic Factor (BDNF) in the striatum of the murine model of Huntington s disease. SANTA LUCIA Brain Disorders and 15, Pagina 100 di 142

101 Assessment of the role of image guided radiotherapy (IGRT) in the treatment of head and neck cancers. A randomized phase III study of chemo radiation for stage III IVa oropharynx cancers: IGRT Intensity Modulated Radiotherapy (IMRT) with dose fraction esc ARCISPEDALE Oncology 2 15, POSSIBLE ROLE OF 18F FDG PET/CT IN DEFINING THE APPROPRIATE USE OF PRRT IN PATIENTS WITH METASTATIC GEP NETs WITH EVIDENCE OF TUMOUR PROGRESSION FOLLOWING TREATMENT WITH SOMATOSTATIN ANALOGUES. ISTITUTO TUMORI MILANO Oncology 2 15, The burden of arterial and venous thromboembolism in the Italian active population: a twenty years long prospective VITA (VIcenza Thrombophilia and Atherosclerosis) COhort STudy (VITA COST) Veneto Vascular and Hematology 15, Non invasive assessment of liver steatosis and fibrosis, and lymph nodes diseases in pediatric patients. SAN MATTEO Surgical Sciences, Biomedical Imaging, and Bioengineering 15, Homocysteine serum levels in patients with cutaneous lupus erythematosus: pathogenetic and therapeutic implications. Toscana Musculoskeletal, Oral and Skin Sciences 15, Prevention of recurrence of idiopathic calcium stones and risk of developing associated diseases: a study of saltsensitivity genetics, urinary phenotype risk and body composition. Emilia Romagna Digestive, Kidney and Urological Systems 15, HIV STDs coinfection in treated MSM patients: measurement of plasmatic and seminal HIV Viral Load Lombardia Infectious Diseases and Microbiology 15, Interim FDG PET/CT in the assessment of early response to concurrent chemo radiotherapy in patients with nonsmall cell lung cancer stage IIIA IIIB ARCISPEDALE Oncology 2 15, Genetic polymorphisms in genes of drug related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma. I. O. V. Oncology 2 15, Pagina 101 di 142

102 D.A.I.P.P. Assessment of influencing factors in diabetes incidence and progression in paediatric immigrant population Piemonte Healthcare Delivery and 15, ROLE OF HUMAN PAPILLOMAVIRUS IN THE DEVELOPMENT OF PENILE CANCER IN PATIENTS WITH LICHEN SCLEROSUS: NICAL, VIDEODERMATOSCOPIC, HISTOPATHOLOGIC AND MOLECULAR STUDY Sicilia Oncology 1 Basic 15, Innovative biomarkers for prevention, diagnosis and prognosis of colorectal cancer ARCISPEDALE Oncology 2 15, Resistin as a biomarker of coronary artery disease, major cardiovascular events and all cause mortality in patients with type 2 diabetes. CASA SOLLIEVO SOFFERENZA Vascular and Hematology 15, Role of extracellular Tat in HIV infection Istituto Superiore di Sanita' AIDS and Related Research 15, High resolution array CGH study in patients with infancy epileptic encephalopathies of unknown etiology. OASI MARIA S.S. Brain Disorders and 15, Na+ Ca2+ exchanger 1 (NCX1) as new potential therapeutic target in the management of bacteriainduced heart hypertrophy and related complications Marche Cardiovascular and 15, Role of polymorphisms of genes involved in alloreactive response in kidney transplantation: implications for personalized post transplant therapies Abruzzo Immunology 15, Imaging and molecular analysis of brain inflammation in depression: a translational approach Brain Disorders and 15, Development of an easily available Monte Carlo based tool to improve dose delivery accuracy in helical tomotherapy Istituto Superiore di Sanita' Oncology 2 15, Pagina 102 di 142

103 ANORECTAL MALFORMATIONS (ARM): A MULTIDISCIPLINARY RESEARCH TO IDENTIFY PREDISPOSING FACTORS AND NEW THERAPEUTICAL APPROACHES Veneto Genes, Genomes and Genetics 15, The Salivary Proteomics biomarkers for Alzheimer's disease study (SaP AD study) Sicilia Brain Disorders and 15, Allergic contact dermatitis to nickel and related alloys SAN GALLICANO Cardiovascular and 15, High throughput sequencing to reveal the undesired microbiota in raw cheeses Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 15, Detailed virological characterisation of patients with virological failure receiving integrase inhibitors and/or CCR5 inhibitors: RNA and DNA resistance profile, plasma and cell viral load, V3 loop characterisation and pharmacokinetic profile Istituto Superiore di Sanita' AIDS and Related Research 15, Liver Factory SAN MATTEO Surgical Sciences, Biomedical Imaging, and Bioengineering 15, Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation of prevention strategies. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 15, Development and preclinical testing of novel adenosine 2A receptor antagonists for the treatment of Parkinson s disease and clinical implementation of potential adenosine receptor related biomarkers MONDINO Brain Disorders and 15, Novel approaches to the functional characterization of unclassified variants in BRCA genes. ISTITUTO TUMORI MILANO Oncology 1 Basic 15, Urinary FDG loss and measurement of standardized uptake value "SUV" IRCCS AOU San Martino IST (Genova) Surgical Sciences, Biomedical Imaging, and Bioengineering 15, Pagina 103 di 142

104 Food pyramids and nutritional prevention campaigns CROB Healthcare Delivery and 15, Mice models of osteosarcoma and hemangiosarcoma development. Early molecular and immunological mechanisms involved in tumor onset and malignancy as targets of innovative therapies. RIZZOLI Oncology 1 Basic 15, FACES IV: A DIAGNOSTIC INSTRUMENT TO EVALUATE FAMILY FUNCTIONING IN A SAMPLE OF PATIENTS IN THE PEDIATRIC AGE OSPEDALE BAMBINO GESU' Biobehavioral and Behavioral Processes 15, PROBING THE ROLE OF ION CHANNELS IN NEUROPATHIC PAIN CARLO BESTA Molecular, Cellular, and Developmental 15, INNOVATIVE TREATMENTS FOR NEUROGENETIC DISEASES AND THEIR COMPLICATIONS: ATAXIA TELANGIECTASIA Lazio Genes, Genomes and Genetics 15, Prevalence and clinical impact of Chronic Obstructive Pulmonary Disease (COPD) in patients with cardiovascular disease and predictive power of cardiovascular risk factors in patients with COPD SAN RAFFAELE PISANA Cardiovascular and Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development Istituto Superiore di Sanita' Population Sciences and Epidemiology Epidemiology, Biomolecular Characterization, Phylogenetic Analysis, and Evaluation of Urine Testing Strategy for Diagnosis of Chlamydia and HPV Infections in Migrant Women with Limited Access to Health Care Lombardia Infectious Diseases and Microbiology Cardiac output regulation in artificial hearts MONZINO Cardiovascular and Cardiotoxicity of anticancer treatments. Biomarkers and diagnostic tools for evaluation of cardiological risk of oncological patients MULTIMEDICA Cardiovascular and Pagina 104 di 142

105 Maternal metabolic hormones impact on human breast during pregnancy. Abruzzo Endocrinology, Metabolism, Nutrition and Reproductive Sciences Role of nicotinic receptor subtypes in alcohol tobacco dependence Emilia Romagna Genes, Genomes and Genetics A MULTIDISCIPLINARY EMERGENCY APPROACH TO IMPROVE QUALITY OF CARE AND REDUCE POST TRAUMATIC STRESS DISORDER IN CHILDREN Emilia Romagna Healthcare Delivery and One year follow up of infected fetuses.1) Implementation of clinical pathways for an appropriate/comprehensive care of women infected during pregnancy and of infants with congenital infection.2) Role of innate immunity in the susceptibility to infect OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology INTERMEDIATE INTENSIVE CARE UNIT (IICU CRITICAL AREA ) Emilia Romagna Healthcare Delivery and Evaluation of CARDIac function in patients with chronic LIVER disease (CARDIO LIVER) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering Rehabilitation in Chronic Disability: Connecting Care 2.0 Lombardia Healthcare Delivery and Ultraviolet solar radiation and aromatic hydrocarbons as carcinogenic factors in outdoor workplaces: exposure quantification and biomarkers identification aimed at the identification of principal effects and possible synergistic effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Population Sciences and Epidemiology TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI Oncology Effect of eyes covering on variations of melatonin secretion, electroencephalographic pattern and outcome in patients with severe neurological damage. Emilia Romagna Brain Disorders and Pagina 105 di 142

106 Pharmacological enhancement of tumor cell death by soluble or membrane bound TRAIL and SMAC mimetics ISTITUTO TUMORI MILANO Oncology 1 Basic MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs FATEBENEFRATELLI Biobehavioral and Behavioral Processes Extraneuronal airway cholinergic system and ß2ARs function in stable COPD and control subjects Emilia Romagna Cardiovascular and "Leading nanomedicine into the therapy for Leukodystrophies: nanoparticles overcoming the bloodbrain barrier to treat the mouse model of Krabbe Disease" BURLO GAROFALO Molecular, Cellular, and Developmental Bone Morphogenetic Protein pathway induces Cancer Stem Cells differentiation enhancing the chemosensitivity of breast and colorectal cancers to conventional chemotherapy Sicilia Oncology management of viral infections in pediatric hematopoietic stem cell transplant recipients. Piemonte Infectious Diseases and Microbiology Identification of organs that are reservoir of immunosoppressive cells during tumor development and progression Immunology Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. MAGGIORE Cardiovascular and Human infection from exposure to norovirus: improving diagnostic techniques and correlation analysis between clinical cases and infected food. Developing a network among hospital units and IIZZSS in some Italian regions Istituto Zooprofilattico Sperimentale delle Venezie Infectious Diseases and Microbiology Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area DE BELLIS Population Sciences and Epidemiology Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis Istituto Superiore di Sanita' Digestive, Kidney and Urological Systems Pagina 106 di 142

107 Epigenetic determinants of psoriasis and psoriatic arthritis: diagnostic and prognostic values of DNA methylation patterns Emilia Romagna Musculoskeletal, Oral and Skin Sciences Evaluation of the pharmaco/toxicological profile of new smart drugs of abuse and optimization of targeted analytical procedures for their detection in biological samples Toscana Risk, Prevention and Health Behavior Nanomedicine applied to cerebral ischemia NEUROLESI Brain Disorders and Quitline for smoking cessation in women adhering cervical cancer screening Piemonte Risk, Prevention and Health Behavior Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients with Medullary Thyroid Cancer PASCALE Oncology MicroRNA regulation of cellular signalling pathways: Identification of prognostic and therapeutic biomarkers in high risk soft tissue sarcoma patients RIZZOLI Oncology 1 Basic and molecular mechanisms of accelerated aging in dialysis patients. Abruzzo Biology of Development and Aging 16, Therapeutic heart rate lowering in coronary artery disease patients and endothelial shear stress: the likely beneficial link MAUGERI Cardiovascular and 16, NEW MOLECULAR APPROACHES FOR THE DETECTION OF DIOXINS AND DIOXIN LIKE COMPOUNDS IN EXPOSED SHEEP Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 16, A Multi center 3T MR Assessment of T2 Perfusion and T1 Permeability in brain Gliomas: the MAPPING study Oncology 2 16, Near infrared technology for trafficking the fate of stem cells in vivo: a translational study for longitudinal tracking in a rodent model of Parkinson s disease AUXOLOGICO Emerging Technologies and Training in s 16, Pagina 107 di 142

108 CCRL2 as a new therapeutic target in rheumatoid arthritis HUMANITAS Immunology 16, Study of cerebral glucose metabolism by means of positron emission tomography (PET) in psoriatic patients with and without depression major before and after effective anti psoriatic therapies SAN GALLICANO Musculoskeletal, Oral and Skin Sciences 16, MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII ISOLATES BY RAPD AND MLVA ANALYSES Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 16, PROTIC TREATMENT TO PREVENT ALLERGEN SENSITIZATION: A PRENICAL STUDY IN PREGNANT AND NEWBORN MICE Istituto Superiore di Sanita' Immunology 16, PHARMACOGENETICS OF PEMETREXED AND CARBOPLATIN IN MALIGNANT PLEURAL MESOTHELIOMA (MPM) PATIENTS. HUMANITAS Oncology 2 16, and experimental investigations of novel disease mechanisms in pain processing and Parkinson Disease MONDINO Brain Disorders and 16, Salivary gland tumours: molecular and molecularcytogenetic studies to identify diagnostic/prognostic markers and risk factors Istituto Superiore di Sanita' Genes, Genomes and Genetics 16, Development of an innovative strategy based on the use of lytic bacteriophages for an effective and safe treatment of irrigation and washing waters of crops Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 16, TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES AND NICAL APPROACHES IN GASTRIC CARCINOMA THAT PROVIDE INFORMATIVE CLUES FOR EARLY DIAGNOSIS AND TREATMENT OF GASTRIC CANCER C.R.O. AVIANO Oncology 2 16, Search for new mutations and polymorphisms of FSHR and LHR genes in hypergonadotropic hypogonadic patients without obvious testicular pathogenic noxa. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16, Pagina 108 di 142

109 High throughput parallel sequencing of Mycobacterium avium subsp. paratuberculosis in sheep, of affected/non affected sheep transcriptome and of environmental samples. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary 16, Detection of Mycobaceterium avium subsp. paratuberculosis in human Crohn s disease and in ruminants and possible role of contaminated food Istituto Zooprofilattico Sperimentale del Mezzogiorno Infectious Diseases and Microbiology 16, The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiency on alterations of bone mineral metabolism in young women with chronic bowel diseases: a pilot study. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16, PGD in genetic alteration and repeated failures in IVF patients Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16, A pharmacogenomic approach for Interferons treatment in multiple sclerosis Brain Disorders and 16, PAIN AND ANALGESIA IN THE PRETERM NEWBORN: A LONGITUDINAL STUDY ON NON PHARMACOLOGIC METHODS EFFICACY AND THEIR INFLUENCE ON PAIN PROCESSING CORTICAL MATURATION BURLO GAROFALO Brain Disorders and 16, Development and validation of a set of indicators based on administrative data to monitor long term care for disabled elderly Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 16, Detection and management of Thyroid nodules: assessment of a screening program carried out by General Practitioners ARCISPEDALE Healthcare Delivery and 16, Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating Patients Satisfaction and Multidisciplinary Team Working ISTITUTO TUMORI MILANO Healthcare Delivery and 16, Pagina 109 di 142

110 EasyHIFU: simplified lesion localization for HIFU treatment Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 16, The role of diet in psoriasis ISTITUTO DERMOPATICO DELL'IMMACOLATA Risk, Prevention and Health Behavior 16, Therapeutic targeting of HSP105 in human non Hodgkin lymphomas ISTITUTO TUMORI MILANO Oncology 2 16, Prognostic role of arterial stiffness and vascular calcifications on peripheral arterial occlusive disease in chronic kidney disease. A multi center, observational, prospective, non invasive study. AUXOLOGICO Vascular and Hematology 16, Performance of serum SMRP as screening tool (the cancer predictive values of SMRP ) surveilling a cohort of asbestos exposed individuals Liguria Oncology 2 16, Physiopathological mechanisms of freezing of gait in Parkinson disease and development of rehabilitative therapeutic strategies S.CAMILLO Brain Disorders and 16, Oxidative stress in animals cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumours Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary Guided bone regeneration with innovative degradable scaffolds RIZZOLI Musculoskeletal, Oral and Skin Sciences New prognostic markers and therapies for Merkel cell carcinoma SAN GALLICANO Oncology Hepatitis C virus (HCV) infection beyond the liver: bone and cardiovascular manifestations. Sicilia Musculoskeletal, Oral and Skin Sciences Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, Cost Effective Algorithm Sicilia Oncology Pagina 110 di 142

111 Effectiveness of cognitive remediation in schizophrenia: a prospective, multicenter study in the "real world" setting of Italian psychiatric services Lombardia Brain Disorders and Protective ventilatory strategy in severe brain injured patients: a randomized control trial Piemonte Cardiovascular and The SHARP Study: Simultaneous Hybrid Revascularization by Carotid Stenting and Coronary Artery Bypass Grafting Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering A NEW CARE MODEL TO MAINTAIN FUNCTION IN STROKE PATIENTS:EARLY THERAPEUTIC PATIENT EDUCATION AND LONG TERM GROUP PHYSICAL ACTIVITY(e TEAM2011 : early Therapeutic Education Associated with Movement) ARCISPEDALE Risk, Prevention and Health Behavior Use and integration of clinical and administrative databanks to evaluate the quality and continuity of care processes for epidemiological study and for health planning for patients affected by heart brain vascular diseases. Lombardia Healthcare Delivery and Development and validation of a simple and wearable new system for monitoring sleep and respiratory variables Toscana Bioengineering Sciences and Technologies Post genomic approach to heart failure in diabetic patients SAN DONATO Cardiovascular and The pathophysiological substrates of myoclonic syndromes: implementation of innovative multimodal functional approach and treatments CARLO BESTA Brain Disorders and From diet to cancer: an integrated approach to study the complex path from visceral fat associated inflammation to colon cancer Istituto Superiore di Sanita' Immunology Mechanisms of beneficial effects of physical exercise on healthy aging and neurological age related diseases MAUGERI Biology of Development and Aging Pagina 111 di 142

112 Evaluation of Diagnostic Accuracy of DW and DCE Magnetic Resonance Imaging in the Mesorectal Nodes staging of Rectal Carcinoma ISTITUTO TUMORI MILANO Surgical Sciences, Biomedical Imaging, and Bioengineering The impact of depressive disorders on endothelial progenitor cells in patients with ischemic heart disease Toscana Cardiovascular and Frameless localisation technique for brain stereotactic radiotherapy Toscana Oncology The BRCAness profile: from the molecular basis to the clinical relevance Toscana Oncology 1 Basic GENERATION OF HUMAN MONOCLONAL ANTIBODIES INTERFERING WITH HIV TRANSCYTOSIS FOR THE PREVENTION OF MUCOSAL INFECTION Istituto Superiore di Sanita' AIDS and Related Research Biological foundations of self control and potential diagnostic implications Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes HIV 1 Nef protein affects opportunistic infections in human macrophages Istituto Superiore di Sanita' AIDS and Related Research Glycation/glycoxidation products in the pathogenesis of cardiovascular diseases: a search for new biomarkers of cardiovascular risk Istituto Superiore di Sanita' Cardiovascular and The Italian National Program on Surveillance of Antiretroviral Treatment in Pregnancy Istituto Superiore di Sanita' AIDS and Related Research BREAST CANCER RISK AND DIETARY MICRONUTRIENTS ASSOCIATED WITH ONE CARBON METABOLISM PATHWAY IN BRCA1/2 SUBJECTS: AN OBSERVATIONAL STUDY C.R.O. AVIANO Population Sciences and Epidemiology 17, MULTI CENTER STUDY ON METABOLIC COMPLICATIONS IN HIV INFECTED PEDIATRIC PATIENTS Lombardia AIDS and Related Research 17, Pagina 112 di 142

113 Healthy diet: evaluation of antioxidant capacity of a weekly selected menu in elderly people, and factors affecting its strength. Emilia Romagna Healthcare Delivery and 17, REGISTRY FOR HEREDITARY AND FAMILIAL BREAST CANCER AND IDENTIFICATION OF NEW DISEASE CAUSING GENES AND REGIONS Lombardia Oncology 2 17, Leukocyte telomere length and risk of ischemic vascular disease in an Italian population. Molise Genes, Genomes and Genetics 17, STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST UTILITY ANALYSIS Healthcare Delivery and 17, The effectiveness of Individual Placement and Support (IPS) in clients with first episode of psychosis. Emilia Romagna Healthcare Delivery and 17, High field MR evaluation in low level consciousness patients NEUROLESI Brain Disorders and 17, ROLE OF ENPP1 AND HSP70 SERUM LEVELS ON CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS CASA SOLLIEVO SOFFERENZA Vascular and Hematology 17, Fibrin resistance to lysis in pulmonary hypertension Toscana Cardiovascular and 17, RNA sequencing for the detection of progressive HPV lesions REGINA ELENA Oncology 2 17, Study of three dimensional model analysis for evaluation of pelvic volume in patients with hemodynamic instability due to pelvic fracture. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 17, Identification of prevalence of urinary incontinence in breast cancer women in hormonal treatment. Identification of a diagnostic and therapeutic path. Toscana Healthcare Delivery and 17, Andrological Screening and Reproductive Health in Young Adult Males Veneto Population Sciences and Epidemiology 17, Pagina 113 di 142

114 Molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy of Huntington disease Istituto Superiore di Sanita' Brain Disorders and 17, The effects of different rehabilitation treatments on left unilateral neglect S.CAMILLO Risk, Prevention and Health Behavior 17, Gene expression profile and epigenetic regulation in human white adipose tissue AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 17, Novel POCT device for sepsis diagnosis based on a multiassay optical biochip Toscana Bioengineering Sciences and Technologies Hypertension in children adolescents:predictors,risk factors and intra uterine growth retard Toscana Healthcare Delivery and Effectiveness and cost effectiveness of eating disorder networks in Italy Emilia Romagna Biobehavioral and Behavioral Processes QUANTEC:QUantitative Analysis of Normal Tissue Effects in the Clinic.A Multicenter Italian prospective contribute to international research on radiation therapy damage,through a correlation between clinic,imaging,dosimetry and biology. Lombardia Oncology Association of all trans retinoic acid (ATRA) and trastuzumab for HER 2 positive metastatic breast cancer: a phase II evaluation of ATRA potential immunomodulatory activity for myeloid derived suppressor cells (MDSC). I. O. V. Oncology Reducing the costs associated to post stroke rehabilitation: a novel robot assisted treatment protocol Veneto Emerging Technologies and Training in s Proteomics and transcriptomics studies to define a new role of REP1: insights in the molecular pathogenesis of Choroideremia SDN Cell Biology Pagina 114 di 142

115 Emerging technologies for genome manipulation, detection and characterization of West Nile virus strains Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary IMPROVEMENT OF BREAST CANCER THERAPY BY USING NANOVECTOR DELIVERY SYSTEMS Istituto Superiore di Sanita' Oncology Genotoxic effects related to pesticide exposure: a novel bio monitoring approach IRCCS AOU San Martino IST (Genova) Population Sciences and Epidemiology Identification of new heart related mirnas as tools for diagnosis and terapy of heart malformations and diseases Emilia Romagna Cardiovascular and Continuity of CAre for severe chronic REspiratory patients (CARE) Puglia Healthcare Delivery and Human Mesenchymal Stem Cells as site regulated medicinal cells stimulating endogenous repair mechanisms in tissue injury IRCCS AOU San Martino IST (Genova) Musculoskeletal, Oral and Skin Sciences Neuroplasticity, rehabilitation and work ability Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Brain Disorders and Human Autologous Cardiospheres For The Treatment Of Paediatric Heart Failure OSPEDALE BAMBINO GESU' Cardiovascular and CORRELATIONS OF THE NICO NEUROPHYSIOLOGICAL FEATURES WITH THE HISTOPATHOLOGICAL FINDINGS AND microrna EXPRESSION IN DRUG RESISTANT TEMPORAL LOBE EPILEPSY Istituto Scienze Neurologiche Brain Disorders and Mesenchymal stem cells and T cells in head and neck squamous cell carcinoma: a unified vision of the tumoral stroma for the identification of new prognostic markers and possible therapeutical targets. Toscana Immunology Pagina 115 di 142

116 Functional modifications of Substantia nigra pars reticulata neurons firing upon high frequency stimulation in the Subthalamic nucleus: a parallel investigation on Parkinson s disease patients treated with Deep Brain Stimulation and on rat midbrain slice SANTA LUCIA Brain Disorders and Biomarkers of clinical outcomes in stroke patients. Role of Alfa Melanocortin and Brain Derived Neurotrophic Factor polimorfisms in neurorehabilitation. S.CAMILLO Brain Disorders and Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia Interdisciplinary Molecular Sciences and Training Coronary arteriogenesis with combined pharmacological (dipyridamole and heparin) therapy Toscana Cardiovascular and Primary prevention of Neural Tube Defects (NTD) by Inositol: the ASBI case control study Liguria Risk, Prevention and Health Behavior Effects of early microbiological diagnosis (molecular tests vs standard) on length of stay in Intensive Care Unit Emilia Romagna Infectious Diseases and Microbiology Adenosine receptor imaging and function, and therapeutic targets in Chronic Heart Failure Toscana Cardiovascular and Cranioplasty and rehabilitation for brain injured patients Emilia Romagna Brain Disorders and CORRELATION BETWEEN BREST ARTERIAL CALCIFICATIONS AT MAMMOGRAPHY AND CORONARY ARTERY CALCIUM SCORE IN ASYMPTOMATIC DIABETIC PATIENTS: TWO SCREENING IN ONE SAN DONATO Cardiovascular and New nanotools for permeabilization of Brain Blood Barrier and early detection of Alzheimer disease NEUROMED Emerging Technologies and Training in s Randomized controlled trial on the role of telemonitoring for the management of chronic obstructive pulmonary disease (COPD) Sicilia Cardiovascular and Pagina 116 di 142

117 CORONARY ATHEROSCLEROSIS IN THE YOUNG: EARLY DIAGNOSIS AND IDENTIFICATION OF RISK FACTORS FOR SUDDEN DEATH PREVENTION Veneto Cardiovascular and Effects of ALR administration, a physiological antiapoptotic and anti oxidative molecule, on Parkinson's Disease transgenic mice during the progression of the disease. DE BELLIS Brain Disorders and Next Generation Sequencing approaches for Diagnostics of common and rare genetic diseases NEUROMED Genes, Genomes and Genetics microrna deregulation in atrial fibrillation: identification of pathogenetic mechanisms and of peripheral blood biomarkers SAN DONATO Cardiovascular and Deployment of the trigger tools within the electronic medical record to enhance error detection in Neonatal Intensive Care Units (NICU): a cluster, randomized trial Lombardia Healthcare Delivery and Four dimensions augmented reality navigation system for medical interventions CASA SOLLIEVO SOFFERENZA Surgical Sciences, Biomedical Imaging, and Bioengineering Identification of novel functional and biological parameters to predict the response to cardiac resynchronization therapy SAN MATTEO Cardiovascular and Surgical aortic valve replacement versus transcatheter aortic valve implantation in patients 80 years and older at low surgical risk:the ELDERLY VALVE Trial Cardiovascular and Study of the role of immune activation and immune senescence in the pathogenesis of atherosclerosis and bone metabolism disorders in HIV infected patients undergoing highly active antiretroviral therapy (HAART) Lombardia AIDS and Related Research Investigation of link between Lung Cancer Stem Cells (CSCs) and Epithelial Mesenchymal Transition (EMT) for tumour progression and metastatis PASCALE Oncology 1 Basic 18, Pagina 117 di 142

118 Cognitive rehabilitation after stroke: a randomized controlled trial to compare the efficacy of different protocols. Sicilia Brain Disorders and 18, Predictive models of genito urinary and sexual dysfunction after high dose radiotherapy for prostate cancer ISTITUTO TUMORI MILANO Oncology 2 18, THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A NICAL, MORPHOLOGIAL CEREBRAL AND LOGICAL COMPARISON STUDY FATEBENEFRATELLI Brain Disorders and 18, IDENTIFICATION OF GENETIC RISK FOR MELANOMA AND CANCERS OTHER THAN MELANOMA IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA SAN MATTEO Oncology 1 Basic 18, Biomarkers for optimization of Attention Deficit Hyperactivity Disorder (ADHD) pharmacological therapy FATEBENEFRATELLI Biobehavioral and Behavioral Processes 18, Optimising Natural Killer (NK) cell activation for liver anti fibrogenic immunotherapy. Epstein Barr virus infection and risk of developing autoimmune disease SAN MATTEO Immunology 18, Istituto Superiore di Sanita' Immunology 18, Deciphering the Transcriptional Signature of Sporadic Brain Arteriovenous Malformations: a Genome Wide Expression Study Istituto Superiore di Sanita' Brain Disorders and 18, DESIGN OF NOVEL RATIONAL THERAPEUTIC STRATEGIES FOR RET DRIVEN MEDULLARY THYROID CARCINOMA ISTITUTO TUMORI MILANO Oncology 1 Basic 18, Congenital malformations in domestic ruminant calves in southern Italy: a study of the main genetic, toxicological and infective causes Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 18, Pagina 118 di 142

119 Metabolic and cardiovascular risk in non obese and obese patients with obstructive sleep apnea: long term follow up Sicilia Population Sciences and Epidemiology 18, ANTIOXIDANT PROTECTION IN HIV RELATED NEURODEGENERATIVE DISORDERS Improving accuracy in cardiovascular disease risk prediction by metabolic markers in the Italian population Calabria AIDS and Related Research 18, Lombardia Vascular and Hematology 18, Role of hypoxia in glioblastoma metabolism. Looking for new therapeutic strategies to counteract tumor progression and recurrencies Abruzzo Oncology 1 Basic 18, OBESITY AND MALE HYPOGONADISM: WHO COMES FIRST? SAN DONATO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 18, BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by The Program of Molecular & Endocrinology and Women s Endocrine Health. Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 18, Identification and biological characterization of individuals at risk for hereditary colorectal tumors Emilia Romagna Genes, Genomes and Genetics 18, A study to identify and validate predictive biomarkers for clinical outcome after oxaliplatin based adjuvant chemotherapy (CT) in early stage colorectal cancer (ecrc) and bevacizumab based CT in metastatic colorectal cancer (mcrc) HUMANITAS Oncology 2 18, THE ROLE OF EARLY SCREENING IN PERINATAL DEPRESSION Toscana Risk, Prevention and Health Behavior 18, Prediction of response to targeted therapies in esophageal adenocarcinoma patients using an endoscopic biopsies xenograft rat model. I. O. V. Oncology 2 18, Pagina 119 di 142

120 A MULTIMODALITY APPROACH TO PREVENT THE NEUROLOGICAL DYSFUNCTION IN CARDIAC SURGERY Veneto Brain Disorders and 18, Strategies of psychological support in the context of clinical medical treatments aimed at preserving fertility in oncology, for women of childbearing age and girls of prepubertal age candidate for ovarian tissue banking. REGINA ELENA Risk, Prevention and Health Behavior 18, Natural Chemistry and Physical Energy to Optimize Stem Cell Therapy of Vascular Diseases Emilia Romagna Vascular and Hematology 18, Does adolescents perception of parental and peer drinking habits and lifestyle affect their approach to alcohol consumption? Molise Healthcare Delivery and 18, Emerging and Re emerging Viral Infections in the Tuscany Region Toscana Infectious Diseases and Microbiology 18, Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of low and intermediate risk prostate cancer Emilia Romagna Oncology Mediterranean Dietary to prevent conversion of Mild Cognitive Impairment to Alzheimer Disease: a randomized trial. CARLO BESTA Brain Disorders and HOSPITAL PROCEDURES FOR ACUTE HEART FAILURE AND INTEGRATED COUNTRY/HOSPITAL CARE Sicilia Cardiovascular and Host/Tumor Tailored Clock Chemotherapy: fighting cancer around the clock CASA SOLLIEVO SOFFERENZA Oncology 1 Basic AEQUITAS: Inequality and Quality of regional clinical pathways in diabetes management Marche Population Sciences and Epidemiology Impact of tobacco control policies and implementation of tobacco control interventions Toscana Risk, Prevention and Health Behavior Pagina 120 di 142

121 Development of a Preclinical Model of Peritoneal Carcinomatosis with Cells from patients with Human Gastric Cancer Oncology 1 Basic Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresistance Veneto Oncology Cheyne Stokes respiration in heart failure patients: from the identification of individual pathophysiological mechanisms to individualized treatment MAUGERI Cardiovascular and Metformin plus standard chemotherapy: a new weapon to target tumor initiating cells in colorectal cancer treatment and prevention ISTITUTO TUMORI MILANO Oncology The personalized antidepressant therapy: from the genetic to clinical impact Provincia autonoma Bolzano Emerging Technologies and Training in s A stem cell platform to identify adverse effects of toxicants: an integrated environmental analysis (food, air and water) MAUGERI Cardiovascular and Next Generation Sequencing techniques open up new possibilities in the knowledge and diagnosis of hereditary arrhythmogenic diseases Piemonte Cardiovascular and and prognostic evaluation of thoracic aortic aneurysms: integration between MRI indexes, biological and biomechanical properties Toscana Cardiovascular and Autophagy inhibition in chronic myelogenous leukemia stem cells: the way to the cure? IRCCS AOU San Martino IST (Genova) Vascular and Hematology Development of predictive models based on clinical indicators, dosimetry and bioimaging to describe the dose effect due to laser treatment of skin cancer lesions SAN GALLICANO Oncology Genetic determinants of heart failure (HF) Friuli Venezia Giulia Cardiovascular and Pagina 121 di 142

122 EXPERIMENTAL MODELLING OF TUMOR RELAPSE FOR THE DESIGN AND PRE NICAL VALIDATION OF COMBINATORIAL APPROACHES OF TARGETED THERAPY IN ORAL CAVITY CARCINOMAS Emilia Romagna Oncology Identification of metabolic and immunological parameters predictive for the risk of diseases or fertility problems in periparturient dairy cows Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary The early identification of the free radical disease of the newborn. New therapeutic strategies. Toscana Healthcare Delivery and Technological advancement in deep brain stimulation surgery for Parkinsonian patients: use of neuronavigated frameless system Sicilia Brain Disorders and IGF PATHWAY IN NEUROENDOCRINE TUMORS: PROGNOSTIC ROLE AND NOVEL TARGET THERAPY SDN Endocrinology, Metabolism, Nutrition and Reproductive Sciences THE IMPACT OF EPIGENOMICS ON THE IDENTIFICATION OF NEW PROGNOSTIC MARKERS AND INNOVATIVE THERAPIES IN NEUROENDOCRINE TUMORS (NETs) AUXOLOGICO Oncology 1 Basic Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (15 24 years), in Italy Istituto Superiore di Sanita' Population Sciences and Epidemiology 19, Development of a DNA microarray for a rapid and reliable detection of pathogens in ready to eat foods. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 19, Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolyl hydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy MAUGERI Digestive, Kidney and Urological Systems 19, Defective DNA polymerase beta isoforms as protective factors against Alzheimer's disease OASI MARIA S.S. Biology of Development and Aging 19, Pagina 122 di 142

123 Transgenic zebrafish model to visualize proliferation in vivo. PEPTIDE FROM PARIETARIA JUDAICA POLLEN WITH ANTI MICROBIAL ACTIVITY AS A NEW THERAPEUTICAL TOOL: EVALUATION OF INTERACTION WITH THE IMMUNE SYSTEM PRE NICAL DEVELOPMENT OF A HUMAN MONOCLONAL ANTIBODY AGAINST FAS LIGAND FOR THE TREATMENT OF PEMPHIGUS Evaluation of the therapeutic role of mesenchimal stromal cells in a murine model of systemic lupus erythematosus. REGINA ELENA Cell Biology 19, Istituto Superiore di Sanita' Immunology 19, Emilia Romagna Immunology 19, Toscana Immunology 19, Enhancement of NKG2D ligands induced anti tumor response in Hodgkin s lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin metalloproteinase as possible therapeutic targets. Immunology 19, Sudden sensorineural hearing loss: searching for new molecular markers. Emilia Romagna Vascular and Hematology 19, Microvesicles as mediators of cell to cell interaction in hematological malignancies: biological characterization and clinical relevance in Chronic Lymphocytic Leukemia and Myelodysplastic Syndrome Piemonte Oncology 2 19, NCRpos Vd1 T cells: role of a newly disclosed gammadelta T cell subset in eradicatingtumors, in suppressing HIV 1 replication and in modulating the homeostasis of gut mucosalimmunity. HUMANITAS Immunology 19, HEART KIDNEY INTERACTIONS IN CHRONIC AND ACUTE DECOMPENSATED HEART FAILURE Emilia Romagna Cardiovascular and 19, RNA silencing of the Gene for the Augmenter of Liver Regeneration in Hepatocarcinogenesis in vivo. DE BELLIS Oncology 1 Basic 19, Pagina 123 di 142

124 DIGITAL KIDS Emilia Romagna Healthcare Delivery and 19, A longitudinal study to evaluate personality and mood disorders in patients with Multiple sclerosis SANTA LUCIA Brain Disorders and 19, PCA3,ADVANCED MAGNETIC RESONANCE IMAGING TECHNIQUES AND TISSUE AND CIRCULATING MOLECULAR MARKERS IN PROSTATE CANCER: DEFINING A NOVEL DIAGNOSTIC AND PROGNOSTIC ALGORITHM PASCALE Oncology 2 19, Old and new hypoglycemic agents and incidence of cancer in a large cohort of type 2 diabetic patients: the RIACE Study Toscana Risk, Prevention and Health Behavior Physical activity as a strategic measure to reduce drugs consumption and interactions in elderly patients with cardiovascular disease and comorbidity Molise Healthcare Delivery and COCAINE CHEST PAIN Emilia Romagna Risk, Prevention and Health Behavior INSTITUTION OF A REGIONAL MULTIDISCIPLINARY NETWORK FOR FERTILITY PRESERVATION IN CANCER SURVIVORS. CREATION AND IMPLEMENTATION OF AN INNOVATIVE ORGANIZATIONAL MODEL ISTITUTO TUMORI MILANO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Perioperative markers of neurological and lung damage in infants with congenital heart diseases (CHD). A three years follow up study. OSPEDALE BAMBINO GESU' Cardiovascular and EARLY START EXERCISE TRAINING AFTER ACUTE DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE: FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, NEUROHUMORAL ACTIVATION AND QUALITY OF LIFE. MAUGERI Cardiovascular and Analysis of immunogenicity of putative GPI anchored proteins of Babesia for vaccine and diagnostic purposes Istituto Zooprofilattico Sperimentale della Sicilia Veterinary Pagina 124 di 142

125 Analysis of epidemiology and molecular characteristics of emerging salmonella serovars in Italy Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary effect of different therapeutic approaches for thyroidrelated orbitopathy (Graves' orbitopathy) Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences Overcoming chemoresistance in adrenocortical cancer Emilia Romagna Oncology Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury: a latepreclinical study NEUROLESI Brain Disorders and PARP 1 and PARP 2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors in cell lines and in vivo. Toscana Oncology GABAergic modulation of resting state and stimulusinduced activity within the default mode network: a translational investigation on depression. SANTA LUCIA Brain Disorders and Bergamot Polyphenol Fraction as a treatment for metabolic syndrome and related cardiovascular complications: focus on mechanisms and bases of in vivo efficacy SAN RAFFAELE PISANA Endocrinology, Metabolism, Nutrition and Reproductive Sciences ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia Romagna Infectious Diseases and Microbiology Eco epidemiology of M. bovis in a complex rural zoothenic system and identification of wild animals reservoirs Istituto Zooprofilattico Sperimentale della Sicilia Veterinary Pagina 125 di 142

126 PHENOTYPE GENOTYPE CORRELATION IN PATIENTS AFFECTED BY HYPOGONADISM: IMPLICATIONS FOR NICAL MANAGEMENT. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Infectious Diseases and Microbiology Differentiating Ehrlich carcinoma cells and reducing ascites in rats in vivo. A preclinical study. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Oncology 1 Basic Action and object observation treatment in acute stroke patients NEUROMED Brain Disorders and Role of autophagy in the control of regulatory T cells and autoimmunity SANTA LUCIA Immunology Determinants of FDG uptake in Hodgkin disease IRCCS AOU San Martino IST (Genova) Bioengineering Sciences and Technologies TESTING A MODEL FOR THE ASSESSMENT OF APPROPRIATENESS OF THE USE OF DRUGS, WITH ACTIONS TO SUPPORT HEALTH AND SOCIAL CARE TO FRAIL ELDERLY PEOPLE IN THE HOME VIA HOME DELIVERY OF THERAPY AND CONSEQUENT REDUCTION IN PHARMACEUTICAL EXPENDITURE WITHIN THE NA Marche Healthcare Delivery and Vaccination strategies to prevent infections in splenectomized patients SAN MATTEO Immunology Myocardial Fibrosis in Valvular Heart Disease Lazio Cardiovascular and Multimodal approach to the presurgical evaluation of drug resistant epilepsy S.CAMILLO Brain Disorders and Pagina 126 di 142

127 Effect of intensive control of glycemia and associated cardiovascular ( CV ) risk factors on the evolution of severe psychiatric disorders. Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences The unawareness of illness and executive dysfunctions in bipolaroutpatients Piemonte Brain Disorders and Benefits of cognitive training in healthy older adults after identification of risk factors for neurodegeneration MAGGIORE Biology of Development and Aging Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences Neurodegenerative disorders and tumors: epidemiologic and genetic investigation on their relationship. Sicilia Population Sciences and Epidemiology Identification of new gender associated biomarkers in metabolic syndrome Istituto Superiore di Sanita' Cardiovascular and Role of chest physical examination to identifiy patients with early idiopathic pulmonary fibrosis: a multicenter prospective study Emilia Romagna Cardiovascular and Study on transmission patterns of Salmonella enterica serovar 4, 5, 12:i: within pig units Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary Identification of molecular biomarkers to improve the preoperative diagnosis of follicular type thyroid cancer in the TIR3 cytologic stage as determined by classic FNA cytology Emilia Romagna Oncology Multidisciplinary Network for Chronic Pain Prevention. Interregional Model SAN MATTEO Healthcare Delivery and Pharmacogenetics in Psychiatry: genetic susceptibility to psychotropic drugs metabolism CASA SOLLIEVO SOFFERENZA Brain Disorders and 20, Pagina 127 di 142

128 Immunomodulatory effects of umbilical cord Wharton jelly derived human adult mesenchymal stem cells (hucms) on circulating Tc subsets of patients with systemic autoimmune disorders such as: 1) Type 1 diabetes mellitus (T1DM); 2) Connective tissue diseases Umbria Immunology 20, Beneficial impact of Caribbean dances and Mediterranean diet on patients with cardiovascular risk Puglia Cardiovascular and 20, High risk preterm infants: an early diagnostic therapeutic intervention Piemonte Biobehavioral and Behavioral Processes 20, Accuracy and clinical impact of 68 Ga labeled octreotide analogues PET in diagnosis and staging of duodenopancreatic neuroendocrine tumours; proposal of a multicenter, prospective, non randomized clinical trial. ARCISPEDALE Surgical Sciences, Biomedical Imaging, and Bioengineering 20, Evaluation of tolerability and efficacy of sorafenib treatment in patients with hepatocellular carcinoma. Sicilia Oncology 2 20, ENVIROMENTAL ENRICHMENT AS A TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS WITH INTELLECTUAL DISABILITY STELLA MARIS Brain Disorders and 20, Cardiotoxicity from antracyclines and trastuzumab in the adjuvant treatment of breast cancer: early identification of high risk patients with a panel of biomarkers compared to traditional ecocardiographic evaluation. I. O. V. Oncology 2 20, Integration of an inpatient clinical research in medical oncology within an intensity of care focused hospital (ICFH) model Liguria Healthcare Delivery and 20, Genetic and malformation risk associated with techniques of fertilization in vitro (IVF): a comparative prospective study of genetic and ultrasound analyses of fetuses conceived with IVF and spontaneously. BURLO GAROFALO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20, Environmental and biological monitoring of exposure to traffic related air pollution for outdoor workers and evaluation of genotoxic and cardiovascular effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Population Sciences and Epidemiology 20, Pagina 128 di 142

129 INNATE IMMUNE CELL RESPONSE TO HYPOXIC MICROENVIRONMENT: IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS FOR JUVENILE IDIOPATHIC ARTHRITIS Obesity as an intermediate phenotype of cardiovascular disease and cancer: in vivo and in vitro studies on tissue factor expression and related processes GASLINI Immunology 20, Molise Vascular and Hematology 20, Transient Receptor Potential Canonical 1 (TRPC1) in pancreatic cancer: a new actor for NF kb inactivation CASA SOLLIEVO SOFFERENZA Oncology 2 20, New frontiers in breast imaging: contrast enhanced digital mammography. performance of contrastenhanced spectral mammography (CESM SenoBright) in pre surgical evaluation of extent of malignancy in a population of women with breast cancer. I.E.O. Oncology 2 20, BCL XL GENE EXPRESSION QUANTIFICATION FOR MINIMAL RESIDUAL DISEASE DETECTION IN PMF: A NEW MOLECULAR MARKER TO PREDICT EARLY RELAPSE IN JAK2V617F NEGATIVE PATIENTS. IRCCS AOU San Martino IST (Genova) Oncology 2 20, MOLECULAR CHARACTERIZATION OF BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM MAGGIORE Genes, Genomes and Genetics Path to cure CML and Ph+ leukemias Emilia Romagna Oncology Development, Implementation and Evaluation of a Complex Program Focused on Quality of Life Assessment in the Palliative Care Network of the Ligurian Region IRCCS AOU San Martino IST (Genova) Healthcare Delivery and Generic substitution of antidepressant drugs NEUROLESI Brain Disorders and Vitamin D supplements in geriatric major depression Emilia Romagna Brain Disorders and Identification of a multi SNP profiling to predict metabolic syndrome in children OSPEDALE BAMBINO GESU' Genes, Genomes and Genetics Pagina 129 di 142

130 Epigenetic alterations in nicotine and alcohol dependence Emilia Romagna Brain Disorders and ROLE OF GENE POLYMORPHISMS IN PREDICTING EFFICACY AND TOXICITY IN DIFFUSE LARGE B CELL LYMPHOMA PATIENTS TREATED WITH R CHOP IMMUNOCHEMOTHERAPY Toscana Oncology Purification and utilization of adult adipose derived mesenchymal stem cells (ADMSC) from rat adipose tissue and their transdifferentation toward endothelial cells for kidney function recovery Istituto Zooprofilattico Sperimentale della Sicilia Digestive, Kidney and Urological Systems Sonochemotherapy. A new combined approach of sonoporation plus chemotherapy for the treatment of poorly chemosensitive cancers. Emilia Romagna Oncology Innovative Tool for Uni compartmental Knee Prostheses & Evolution of Guidelines. RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 21, Role of PPAR (Peroxisome Proliferator Activated Receptors) alpha ligands in modulating allergen induced inflammatory and dysfunctional alterations of the airways. MAUGERI Cardiovascular and 21, Conservative and surgical care pathway in patients with neuromuscular scoliosis RIZZOLI Musculoskeletal, Oral and Skin Sciences 21, relevance of detecting EpCAM+ tumour cells in peripheral blood and in bone marrow in patients with hepatocellular carcinoma Piemonte Digestive, Kidney and Urological Systems 21, Markers of gluten sensitivity in unipolar and bipolar disorders Toscana Immunology 21, Impact of thrombophilia on risk of perinatal stroke in neonates: a prospective study OSPEDALE BAMBINO GESU' Vascular and Hematology 21, Major Depression in Systemic lupus erythematosus: a possible link between neurobiological aspects and biohumoral milieu Toscana Brain Disorders and 21, Pagina 130 di 142

131 Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in the aetiopathogenesis of the Williams Beuren Syndrome. Brain Disorders and 21, Development of a multiplex standard polymerase chain reaction assay for identification of infectious agents from aborted ruminants clinical samples Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 21, The role Inflammation and wound healing mechanisms in lung cancer biological behaviour and outcome prediction after surgical resection HUMANITAS Oncology 1 Basic 21, Cytokine secretion phenotype of airway immune cells in inflammatory and infectious diseases of the human lung Toscana Immunology 21, Study of bacterial, parasitic and viral pathogens found in animal and vegetables food matrices, currently not covered by the national and European laws, with particular reference to the list of zoonotic agents. Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 21, EARLY NEURAL CONNECTIVITY DEVELOPMENT: A PRENATAL FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Veneto Biology of Development and Aging Prognostic role of melanoma follow upa prospective randomised study I.E.O. Oncology In Vivo Detection of Cholangiocarcinoma at ERCP: Confocal Laser Endomicroscopy and Intraductal Aspiration. Sicilia Oncology Imaging in clinical MR spectroscopy: reconstruction of high spatial resolution metabolic maps Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering Development of a new synthetic coronary bypass graft for coronary artery bypass grafting Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 131 di 142

132 Corrective cardiac surgery in utero: a new frontier for the management of the unborn child and for perinatal medicine Toscana Cardiovascular and Smoking behavior in patients with established ischemic vascular disease from the Moli sani cohort study Molise Population Sciences and Epidemiology Towards the understanding of the molecular bases of HIV latency AIDS and Related Research mirna and vascular diseases: role of mir149, mir155, mir31, mir126, mir17 3p in endothelial dysfunction IRCCS AOU San Martino IST (Genova) Vascular and Hematology Thyroid hormone treatment as a novel therapeutic strategy to prevent post ischemic cardiac remodeling Toscana Cardiovascular and Effects of sleep disturbances on the occurrence of postextubation respiratory failure and related mortality Emilia Romagna Cardiovascular and Learn and live: extended training for a safer hospital HUMANITAS Healthcare Delivery and Assessment of left ventricular systolic and diastolic dysfunction in patients with pre clinical and overt heart failure. Sicilia Cardiovascular and Pediatric headaches: utility of "RED FLAGS" in the use of CT and MRI Sicilia Healthcare Delivery and Clinic evaluation of Cervista(TM)HR HPV as Screening Test Abruzzo Interdisciplinary Molecular Sciences and Training IMMUNE RESPONSE AND VDRS POLYMORPHISMS IN INFANTS AND CHILDREN EARLY SUPPLEMENTED WITH ORAL CHOLECALCIFEROL. Lombardia Immunology Enhancing the efficacy and the efficiency of obesity treatment through the psicological assessment of obese patients. Piemonte Risk, Prevention and Health Behavior Pagina 132 di 142

133 Pulmonary Rehabilitation in Lung Cancer surgical patients. SAN RAFFAELE PISANA Cardiovascular and Possible role of injured vascular cell derived microvesicles on pericyte vessel destabilization. Piemonte Oncology 1 Basic 22, Identification of mechanisms of resistance to EGFR tyrosine kinase inhibitors in non small cell lung carcinoma (NSCLC) and monitoring the molecular evolution of lung tumors PASCALE Oncology 2 22, Observational prospective study of pulmonary groundglass nodules: meaning and efficacy of CAD detection for neoplastic patients. I. O. V. Oncology 2 22, Tubercolosis in neonates and infants: novel approach to the diagnosis and to the management. OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology 22, Pharmacogenomics of clopidogrel in acute coronary syndromes. Emilia Romagna Cardiovascular and 22, Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. Toscana Population Sciences and Epidemiology Olfactory dysfunction: neurophysiological, neuropsychological and functional magnetic resonance assessment for the early detection of Alzheimer's disease. Toscana Brain Disorders and Evaluation of triethylamine / triethylamine oxidized (TMA / TMAO) in patients with autosomal dominant familial hypercholesterolemia (ADH) Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Omic's in Blastocoele Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 133 di 142

134 Characterization of a mouse model of creatine transporter deficiency:development of new therapeutic strategies for an untreatable inherited disorder of metabolism STELLA MARIS Brain Disorders and BACKGROUND VALUES OF ESSENTIAL TRACE ELEMENTS, TOXICANTS AND THEIR METABOLITES IN THE ITALIAN GENERAL POPULATION MAUGERI Population Sciences and Epidemiology An Innovative Microchip based Deep Brain Stimulation Device for Improved Treatment and Rehabilitation of Parkinson s Patients GALEAZZI Brain Disorders and WIRVA Wireless control of Internal Routes and Vital signs monitoring for patients moving within hospital Areas Sicilia Healthcare Delivery and ESTABLISHMENT OF A SENIOR EMERGENCY ROOM FOR FRAIL ELDERLY AND PATIENTS WITH DEMENTIA Emilia Romagna Healthcare Delivery and Visual function in newborn at term and preterm at risk of brain damage: a new neonatal assessment visual european grid and correlations with neurodevelopmental outcome at short term (Naveg Project) MONDINO Integrative, Functional, and Cognitive Negative pressure therapy : model of Haealth management Hospital to territory Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering COMPREHENSIVE APPROACH TO THE TREATMENT OF ATRIAL FIBRILLATION: NEW MULTIDISCIPLINAR FLOW CHART FOR EARLY DIAGNOSIS AND EARLY TREATMENT Cardiovascular and Obstructive sleep apnea as a cause of resistant hypertension: impact of CPAP treatment on blood pressure and number of antihypertensive medications Risk, Prevention and Health Behavior Intrabone cord blood transplantation for hematological malignancies Emilia Romagna Vascular and Hematology Pagina 134 di 142

135 Oxidative stress and fat profile in neuromuscular disorders with pediatric onset before and after a rationally modified dietary regimen. Istituto Scienze Neurologiche Brain Disorders and Global prospective evaluation of the in vivo clinical efficacy and of the ex vivo bio mechanical properties of the biological meshes employed in thoracic abdominalpelvic wall reconstructive surgery. Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 23, Wnt related proteins in the peripheral blood as potential predictors of response to lithium treatment in bipolar patients. NEUROMED Brain Disorders and 23, research in breast cancer metastases to the brain: a multidisciplinary approach to identify molecular pathways for the development of new therapeutic strategies I.E.O. Oncology 2 23, From new cancer drug registries to appropriateness of care and determinants of (regional) variability: implementing a new monitoring system to evaluate evidence based guidelines Emilia Romagna Oncology 2 23, Echografic detection of Hepatocellular carcinoma with a 3 dimensional ultrasound with contrast media in cirrhotic patients. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 23, Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility: prevention and treatment in Italian and Sudanese/Ethiopian populations. MEDEA Brain Disorders and 23, Identification of molecular markers to determine new therapeutic strategies for Phase II Trials (GCP criteria) in patients with Glioblastomas NEUROMED Oncology 2 23, Development of methods to sub type Clostridium botulinum from animals to support epidemiological investigations and set up of a sera and vaccine bank for treatment and prevention of type C and D animal botulism Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 23, Pagina 135 di 142

136 A multicentric case control study on Gastrointestinal (GI) microbiota, diet and immune system activation: effects of microbial modulation in healthy subjects and patients affected by Irritable Bowel Sydrome and Inflammatory Bowel Disease. Istituto Superiore di Sanita' Infectious Diseases and Microbiology 23, Effects of the prebiotic inulin in the treatment of chemotherapy induced mucositis and related alterations in gut microbiota DE BELLIS Oncology Impact of patient's and physician's gender on the prescriptions of cardiovascular and antidiabetic pharmacological agents in a community setting Toscana Cardiovascular and Identification in patients with gastric cancer of molecular events predictive of peritoneal carcinomatosis and of the response to heated intraperitoneal chemotherapy. Digestive, Kidney and Urological Systems Type 2 Diabetes Mellitus and Alzheimer's Disease: towards a common treatment? Piemonte Integrative, Functional, and Cognitive NICAL AND LOGICAL INVESTIGATIONS IN PATIENTS WITH PRIMARY PLASMA CELL LEUKEMIA RECEIVING A TRIPLE COMBINATION OF BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE AS FIRST LINE TREATMENT CROB Oncology A COMMON SCORE TO EVALUATE NICAL AND LOGICAL ASPECTS OF ACUTE MYELOID LEUKEMIA (AML) IN ELDERLY PATIENTS AIMED TO ENSURE HOMOGENEOUS DIAGNOSTIC AND TREATMENT CRITERIA IN THE HAEMATOLOGY UNITS IN EMILIA ROMAGNA. Emilia Romagna Oncology IDENTIFICATION OF NEURODEVELOPMENTAL RISK FACTORS FROM GESTATION TO BIRTH: PRENATAL DIAGNOSIS OF NEUROLOGICAL DISEASE, MANAGEMENT IN NICU AND EARLY REHABILITATION CARE.ESTABLISHMENT OF A MULTIDISCIPLINARY DIAGNOSTIC AND THERAPEUTIC PATHWAY FOR THE NEWBO Sicilia Brain Disorders and Pagina 136 di 142

137 Optimization of diagnostic and clinical management of patients with combined chronic obstructive pulmonary and ischemic heart disease. MAUGERI Cardiovascular and Inflammation, angiogenesis and micrornas in malignant mesothelioma. Toscana Oncology 1 Basic Bioethical issues in the use of the new criteria for Prodromal Alzheimer disease: disclosure of the diagnosis, clinical trials, social impact. FATEBENEFRATELLI Brain Disorders and Array CGH analysis of copy number variation (CNV) in patients with Hemophilia A: possible relationship with FVIII inhibitor development CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics Virus host interaction in Influenza A and Hepacivirus infections: ecological and molecular studies Istituto Superiore di Sanita' Veterinary Systemic Treatment plus Radiofrequency Ablation versus systemic treatment alone in patients with non resectable colorectal liver metastases. Emilia Romagna Oncology Diagnosis and Management in Sicilian patients with Rare Diseases leading to Intellectual Disability: a Community evaluation and shared plan of improvement. OASI MARIA S.S. Healthcare Delivery and IntraOperative Imaging Technologies (IOIT): supporting decision making process in the Italian National Health Care System (NHS) Agenzia per i Servizi Sanitari Regionali Surgical Sciences, Biomedical Imaging, and Bioengineering 24, Efficacy and safety of early and intensive rehabilitative interventions in patients with stroke. A randomized controlled trial SANTA LUCIA Brain Disorders and 24, Antimicrobial resistance and Zoonoses in Wildlife: Emerging Issues. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 24, Targeting MicroRNA profile in cancer associated angiogenesis: new therapeutical and prognostic tools. Abruzzo Oncology 2 24, Pagina 137 di 142

138 Optimization of the number of fractions in hypofractionated external beam radiation therapy: suggestions from fitting a reoxygenation including TCP model to in vivo and to clinical data. Veneto Oncology 2 24, MARKERS OF ENDOTHELIAL PROLIFERATION IN BREAST AND COLORECTAL CANCERS: A NEW PROSPECTIVE FOR TARGET THERAPY. Sicilia Oncology 2 24, DETECTION OF C KIT ; BRAF AND N RAS MUTATION IN NAIL MELANOMA Emilia Romagna Genes, Genomes and Genetics 24, Characterization of extrapyramidal features in mitochondrial disorders S.CAMILLO Brain Disorders and 24, Epitope mapping of Pru p 3 with multiple antigen or linear peptides: new approaches for the diagnosis and follow up of patients with severe IgE mediated reactions to food Toscana Immunology 24, THE SIGNATURE OF TRANSCRIPTION FACTORS INVOLVED IN AGGRESSIVE OVARIAN CANCER Molise Oncology 2 24, Pain in post surgical hip and knee rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain free therapeutic algorithm. DON GNOCCHI Musculoskeletal, Oral and Skin Sciences Cognitive stimulation versus music therapy in patients with cognitive impairment secondary to multiple sclerosis or brain tumor CARLO BESTA Brain Disorders and Role of peritoneal dialysis in the treatment of refractory heart failure Puglia Cardiovascular and NICAL AND SOCIAL GOVERNANCE OF MIGRANTS OF MEDITERRANEAN Sicilia Healthcare Delivery and Cluster randomized trial to assess the effectiveness of a population based educational campaign on stroke symptom recognition in reducing pre hospital delay. Emilia Romagna Healthcare Delivery and Pagina 138 di 142

139 Affective symptoms dimensions and treatment outcome in unipolar and bipolar depression. Sicilia Brain Disorders and 25, ESTABLISHING THE IN VIVO THRESHOLD FOR AMYLOID DEPOSITION IN PRODROMAL TYPICAL AND ATYPICAL ALZHEIMER DISEASE Toscana Brain Disorders and 25, The role of oxytocin in anxiety disorders FATEBENEFRATELLI Brain Disorders and 25, IATRIS neuroscience: a critical reassessment of preclinical studies in neurologic diseases. Istituto Superiore di Sanita' Brain Disorders and 25, Taxi Doctor Healthcare Delivery and 25, Monitoring of heavy metals and nanoparticles in fishes and babyfoods of animal origin Istituto Zooprofilattico Sperimentale della Sicilia Risk, Prevention and Health Behavior EXPERIMENTAL AND NICAL USE OF STEM CELLS IN THE TREATMENT OF HEART FAILURE Sicilia Cardiovascular and CPAP (CONTINUOUS POSITIVE AIRWAY PRESSURE) FOR SLEEP DISORDERS IN CHRONIC HEART FAILURE Emilia Romagna Cardiovascular and Identification of biomarkers to be predictive of response to anti CTLA4 treatment in the peripheral blood and tissues of melanoma patients. Pathogenesis of Multiple Sclerosis: role of Fas/FasLigand and TNFalfa/TNFR1 and TNFR2 systems in the apoptosis of T cells autoreactive to myelin PASCALE Immunology NEUROLESI Immunology 26, Treatment of Kaposi s Sarcoma by Electrochemotherapy: and Virological evaluation SAN GALLICANO Surgical Sciences, Biomedical Imaging, and Bioengineering 26, Analysis of specific markers of mental health, after time by admissions to a hospital, for onset of psychiatric disorders in developmental age. Sicilia Biobehavioral and Behavioral Processes 26, Pagina 139 di 142

140 Title: Study on target therapies Impact in breast cancer patients on a wide area ofnorthern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma,Piacenza Tumour Registry ARCISPEDALE Oncology LIMIT LOAD AND THE MECHANICAL RESPONSE TO THE PHYSIOTHERAPY TREATMENT OF THE NEURO MUSCULAR DEFICIENCY MAUGERI Bioengineering Sciences and Technologies IDENTIFICATION AND ANALYSIS OF MOLECULAR MECHANISM IN SPORADIC AND FAMILIAL FORMS OF CCM. NEUROLESI Brain Disorders and Development of autoantibody signatures as powerful diagnostic/prognostic biomarkers of inflammatory disorders of the nervous system Evaluation of circulating endothelial cells as a biomarker of endothelial damage in patients undergoing allogeneic stem cells transplantation (allobmt): correlation with graft versus host disease (GVHD) onset. Toscana Immunology Lombardia Vascular and Hematology Induced Pluripotent Stem Cells for neurodegenerative disease Abruzzo Emerging Technologies and Training in s How to personalize the classic and atypical antipsychotic therapy in elderly patients affected by dementia: a pharmacogenetic study. Piemonte Brain Disorders and 27, Mechanisms of T lymphocyte immunomodulation: role of IL 27 in the Th1/Tc1 induction in chronic obstructive pulmonary disease (COPD) MAUGERI Cardiovascular and 27, Alpha Synuclein as a possible predictive and prognostic marker for Parkinson's Disease Istituto Superiore di Sanita' Brain Disorders and Thermalism role in the management of arthralgia in women treated with aromatase inhibitors Piemonte Oncology Pagina 140 di 142

141 Value of MR combined Imaging in assessment of early response to neoadjuvant theraphy in Locally Advanced Breast Cancer PASCALE Oncology Randomized controlled clinical trial comparing Y90 TARE (Transarterial Radioembolisation with Y90) to sorafenib in the treatment of advanced HCC complicated with portal vein thrombosis Emilia Romagna Digestive, Kidney and Urological Systems 28, TREATMENT OF EARLY STAGE (I II) OROPHARYNGEAL CANCER WITH TRANSORAL ROBOTIC SURGERY VERSUS ESCLUSIVE RADIOTHERAPY: PROSPECTIVE MULTICENTER RANDOMIZED STUDY. I.E.O. Oncology 2 28, A MODEL TO EVALUATE EFFECTIVENESS AND APPROPRIATENESS OF DRUGS USING THE ITALIAN RFOM REGISTRY I. O. V. Healthcare Delivery and Develop of new whole body Dosemeter for measuring ionizing Radiation to Operators in medical practice and of STErilizable wrist dosemeter (DROSTE) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering Molecular profiles in Male Breast Cancer (MBC) Sicilia Oncology Role of T cell subpopulations in the pathogenesis of Multiple Sclerosis NEUROLESI Immunology Realization of a complete model of the cardiocirculatory system, by means of hybrid modelling, for testing implant strategies of prosthetic devices. Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 29, An endoscopic information system for the achievement and the distribution of clinical images and video associated to the surgical procedures Sicilia Surgical Sciences, Biomedical Imaging, and Bioengineering 29, Prevention and treatment of atherosclerotic vascular disease in people living in the same geographical area. Veneto Vascular and Hematology Pagina 141 di 142

142 Genotypes of Toxoplasma gondii their phylogeny, pathogenicity and transmission among wildlife, livestock and humans. Eating ectoparasites is an additional factor of risk for infection? Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary CONTROL AND MANAGEMENT OF LOGICAL FOOD RISKS: SETUP AND APPLICATION OF INNOVATING MODELS BASED ON TECHNOLOGICAL METHODS FOR DETECTION OF VIRUS, PARASITES AND BACTERIA Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 30, SUICIDE ATTEMPTS: FROM EPIDEMIOLOGY TO NICAL DIAGNOSIS Emilia Romagna Risk, Prevention and Health Behavior 30, A GROUP COGNITIVE/BEHAVIOURAL INTERVENTION FOR METABOLIC SYNDROME RISK REDUCTION, IN PATIENTS TREATED WITH ATYPICAL ANTIPSYCOTICS Emilia Romagna Biobehavioral and Behavioral Processes 30, Preliminary Study on Bone Tissue Regeneration in Massive Loss of Substance in MusculoSkeletal Oncology REGINA ELENA Musculoskeletal, Oral and Skin Sciences ROLE OF micrornas IN THE PATHOGENESIS OF BARRETT S ESOPHAGOUS Sicilia Oncology Screening of the genetic alterations in patients affected by high myopia Veneto Genes, Genomes and Genetics 33, Role of the master transcription factor Yin Yang 1 (YY1) in the diagnosis of bone lesions SDN Oncology (3) LEGENDA : NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal Bando NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso Bando anche se in altra sezione Pagina 142 di 142