Ministero della Salute

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1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 GIOVANI RICERCATORI e RICERCA FINALIZZATA Tutte le Sezioni RODDI New Robotic Platform for Rehabilitation of Children with Pervasive Developmental Disorders and Cognitive Impairments. CARLO BESTA CLI Biobehavioral and Behavioral Processes Multipotent Stem/Progenitor Cells in Human Extrahepatic Biliary Tree: isolation, culturing, differentiation in vitro and in vivo, identification of intracellular pathways modulating proliferation and differentiation and development of strategies for the t Marche Digestive, Kidney and Urological Systems 4, Role of morgana/chp 1 in myeloproliferative disorders Piemonte Oncology 1 Basic 4, EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread C.R.O. AVIANO Oncology 1 Basic 4, mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Istituto Superiore di Sanita' Oncology 1 Basic 4, Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach Oncology 1 Basic 4, Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity MAUGERI CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 4, Pagina 1 di 31

2 Definition of mechanisms controlling processing and secretion of IL 1beta in health and autoinflammatory diseases, search for novel therapeutic strategies IRCCS AOU San Martino IST (Genova) Immunology 4, NEW GENETIC LESIONS CHARACTERIZING HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS Piemonte EST Oncology 2 4, Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' Immunology strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Piemonte CLI Oncology Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA CLI Oncology Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO CLI Oncology High density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo EEG and post surgical outcome evaluation Lombardia CLI EST Brain Disorders and TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING HUMANITAS Oncology 1 Basic PROTECTIVE AND DANGEROUS IMMUNE RESPONSES DURING HIV 1 INFECTION OSPEDALE BAMBINO GESU' CLI EST AIDS and Related Research Gene therapy for thalassemia: preclinical studies of efficacy and safety Genes, Genomes and Genetics Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia SANTA LUCIA Brain Disorders and Pagina 2 di 31

3 The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets Istituto Superiore di Sanita' Oncology 1 Basic Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Molecular, Cellular, and Developmental Neuroscience Impaired Angiogenesis: a Novel Player and Potential Therapeutic Target in Muscular Dystrophy Istituto Superiore di Sanita' Musculoskeletal, Oral Characterization of the histone deacetylase SIRT1 in human Non Hodgkin Lymphomas and lymph nodes. ARCISPEDALE Oncology 1 Basic STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISER AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Role of Nuclear Receptor Coactivator PGC1 beta in the Intestinal Epithelium ONCOLOGICO DI BARI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration FATEBENEFRATELLI Brain Disorders and 5, Thrombolysis in Minor Stroke Emilia Romagna CLI Brain Disorders and 5, Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 5, Pagina 3 di 31

4 The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V Emilia Romagna CLI Digestive, Kidney and Urological Systems 5, Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche Molecular, Cellular, and Developmental Neuroscience 5, Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes Lazio CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia CLI Population Sciences and Epidemiology 5, Novel surface and intracellular targets for tailored nanotechnology based drug delivery in colorectal cancer SDN EST Oncology 1 Basic 5, Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA Musculoskeletal, Oral 5, Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 5, A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis Digestive, Kidney and Urological Systems 5, IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISERS BY NEXT GENERATION SEQUENCING GASLINI Genes, Genomes and Genetics 5, NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 5, Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Piemonte CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Pagina 4 di 31

5 TRANSLATING MELANOMA EPIGENETICS IN THE CLINICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Toscana Oncology 2 5, Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. PASCALE Oncology 1 Basic Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? S.CAMILLO Brain Disorders and "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. MAGGIORE Digestive, Kidney and Urological Systems CANDIDATE PREDICTORS OF GLUCOCORTICOID RESPONSE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE BURLO GAROFALO CLI Digestive, Kidney and Urological Systems In vivo confocal microscopy of corneal nerves as a novel diagnostic tool in peripheral neuropathies: correlation with skin biopsy, neurophysiology and clinical findings. Lombardia CLI Brain Disorders and Role of TNF related apoptosis inducing ligand (TRAIL) in diabetes mellitus and metabolic syndrome BURLO GAROFALO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA CLI Brain Disorders and THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES SAN DONATO CLI Population Sciences and Epidemiology Identification and functional validation of microrna biomarkers in lung cancer ISTITUTO TUMORI MILANO EST Oncology Pagina 5 di 31

6 PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO CLI Cardiovascular and Respiratory Sciences RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio Cell Biology IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO CLI Oncology THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING CLINICAL DISERS Vascular and Hematology Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Emilia Romagna Brain Disorders and Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man Population Sciences and Epidemiology Improving balance through gravity cues embedded in free falling target SANTA LUCIA Biobehavioral and Behavioral Processes Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Toscana Immunology FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. Genes, Genomes and Genetics Pagina 6 di 31

7 Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer Calabria Oncology Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high through put innovative approaches. GASLINI EST Digestive, Kidney and Urological Systems B7.1 on podocytes: a new therapeutic target for diabetic nephropathy Digestive, Kidney and Urological Systems Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling Lombardia Brain Disorders and And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA Biobehavioral and Behavioral Processes Neuroinflammation and synaptic function: an electrophysiological analysis in experimental multiple sclerosis Umbria Brain Disorders and Transcranial direct current stimulation in the treatment of dyslexia: a randomized double blind study OSPEDALE BAMBINO GESU' Brain Disorders and Insulin resistance and cancer:new strategies of intervention involving the insulin receptor isoform A Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Nurr1 puts a dampener on inflammation: a link between Nurr1 deregulation and Multiple Sclerosis. Piemonte Brain Disorders and Pagina 7 di 31

8 Autosomal Recessive Juvenile Parkinsonism (ARJP) caused by mutation in the PARK2 gene: Identification of the molecular mechanisms by which parkin can modify GluK2 activity and investigation of GluK2 as new target for a neuroprotective therapy AUXOLOGICO Brain Disorders and Perivascular adipose tissue mirnas: links between insulin resistance in type 2 diabetes and vascular disease ISTITUTO DERMOPATICO DELL'IMMACOLATA Endocrinology, Metabolism, Nutrition and Reproductive Sciences Standardizing tissue handling in pre analytical procedures: technological, environmentally safe innovation in solid tumour processing. Piemonte CLI COF Healthcare Delivery Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral Autophagy in the immune response against Mycobacterium tuberculosis: identification of novel rapamycin regulated host targets to improve BCG vaccine immunogenicity. Istituto Superiore di Sanita' EST Infectious Diseases and Microbiology Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer. Toscana CLI EST Oncology Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana CLI Cardiovascular and Respiratory Sciences 6, Generation and characterization of an anticd56 IL15 immunocytokine for functional reconstitution of NK cells in HIV infection Istituto Superiore di Sanita' AIDS and Related Research 6, Amyotrophic lateral sclerosis (ALS) swine models: production and characterization Sperimentale del Piemonte, Liguria e Valle d'aosta Brain Disorders and 6, Pagina 8 di 31

9 PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY C.R.O. AVIANO EST Vascular and Hematology 6, MitoCure: developing treatments for mitochondrial diseases CARLO BESTA Genes, Genomes and Genetics 6, MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio CLI Vascular and Hematology 6, The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial FATEBENEFRATELLI CLI Biobehavioral and Behavioral Processes 6, Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine SAN MATTEO EST Immunology 6, Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Piemonte CLI Brain Disorders and 6, BCR ABL specific T cell Infusion for the Treatment of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Emilia Romagna CLI Oncology 2 6, P2X7 receptor/mmp9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression EST Vascular and Hematology 6, Genetics of Hearing loss: from basic research to clinical applications BURLO GAROFALO CLI Genes, Genomes and Genetics 6, Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution CLI Brain Disorders and 6, Pagina 9 di 31

10 A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Emilia Romagna CLI Digestive, Kidney and Urological Systems 6, CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. Clinical applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 6, Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease IRCCS AOU San Martino IST (Genova) EST Molecular, Cellular, and Developmental Neuroscience 6, Preparatory, response related, outcome evaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation SANTA LUCIA CLI EST Biobehavioral and Behavioral Processes 6, Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO EST Oncology 2 6, Role of HMGB1 redox state in cardiac tissue regeneration and cardiac progenitor cell function MONZINO Cardiovascular and Respiratory Sciences 6, Novel markers based on autophagy proteins in Parkinson's disease NEUROMED CLI Brain Disorders and 6, Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy CLI Digestive, Kidney and Urological Systems 6, The Restless Mind: Default Mode Of Operation Or Risk Factor For Health? SANTA LUCIA Biobehavioral and Behavioral Processes 6, INTEGRATED ''OMIC'' APPROACH TO EXPLORE MOLECULAR PATHOGENESIS AND CLINICAL HETEROGENEITY IN FACIO SCAPULO HUMERAL MUSCULAR DYSTROPHY STELLA MARIS Musculoskeletal, Oral 6, Pagina 10 di 31

11 Spinal Muscular Atrophy with Respiratory Distress (SMARD1): gene therapy as novel therapeutic approach MAGGIORE Genes, Genomes and Genetics 6, Role of the Wnt/beta catenin pathway in orchestrating epigenetic events in Cancer Stem Cells Toscana Genes, Genomes and Genetics 6, The ubiquintin editing enzyme A20 (TNFAIP3) as a peacekeeper in inflammation and immunity: a link between TNFAIP3 deregulation and Multiple Sclerosis Piemonte Brain Disorders and 6, Impact of lincrnas on high serous ovarian cancer C.R.O. AVIANO Oncology 1 Basic 6, Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Sperimentale della Lombardia e dell'emilia Veterinary 6, (5) Production and characterization of clinical grade stem cellderived conditioned medium for treatment of ischemic heart disease. SAN MATTEO Cardiovascular and Respiratory Sciences 6, mtor dependent oscillatory metabolic switch controlling self immune tolerance SANTA LUCIA EST Immunology 6, Brain plasticity in Alzheimer Disease and Mild Cognitive Impairment. Functional, structural and neuropsychological effects of a computer based cognitive treatment SANTA LUCIA CLI Brain Disorders and Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis RIZZOLI CLI Musculoskeletal, Oral Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI CLI Musculoskeletal, Oral Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Lombardia CLI Cardiovascular and Respiratory Sciences Pagina 11 di 31

12 Role of peripheral Schwann cells and muscle in the regeneration of degenerated nerve terminals at the neuromuscular junction. Veneto Brain Disorders and GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinson s Disease SAN RAFFAELE PISANA CLI Brain Disorders and Idiopathic epilepsy: search for new mutations in HCN ion channels CARLO BESTA Brain Disorders and Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' CLI Infectious Diseases and Microbiology FEEDING LOW GRADE INFLAMMATION AND INSULIN RESISTANCE OF THE FOETUS OSPEDALE BAMBINO GESU' Endocrinology, Metabolism, Nutrition and Reproductive Sciences Brain and cognitive dynamics of multiple object processing in normal aging, MCI and Alzheimer disease FATEBENEFRATELLI Biobehavioral and Behavioral Processes Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia SAN MATTEO CLI Genes, Genomes and Genetics New nuclear genes responsible for mitochondrial disorders: identification by high throughput exome sequencing and functional characterization of the corresponding proteins CARLO BESTA Genes, Genomes and Genetics Reorganization of cortical function after surgery for lesional epilepsy in children Toscana CLI Brain Disorders and Micro RNAs regulated by the proto oncogene Pbx1 as therapeutic targets to induce differentiation of cancer cells HUMANITAS Oncology Pagina 12 di 31

13 The role of IG20, a novel human gene, and its potential use as therapeutic target in the anaplastic thyroid cancer. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences Role of ATM kinase in ErbB2 signaling: a novel therapeutic target to hit ErbB2 positive breast cancer stem cells? SANTA LUCIA Oncology MULTITHERAPEUTIC APPROACH TO THE SPINAL C INJURY BYSMART HYDROGEL DELIVERY MAGGIORE Brain Disorders and Adipose Derived Stem Cells (ADSCs) in Suspension: Phenotyping, Differentiation and Engineering for Cranial Vault Reconstruction. Sicilia Surgical Sciences, Biomedical Imaging, and Bioengineering The effects of diabetic autonomic neuropathy on postischemic bone marrow mobilization of endothelial progenitor cells. A translational study focusing on the role of Sirtuin 1 Veneto Vascular and Hematology TArgeted Multistage vector (MSV) for the DIagnosis and treatment of Solid tumors Veneto EST Bioengineering Sciences and Technologies SALUTE CKD (SALt lowering by Urine sodium selfmeasurement Trial in Chronic Kidney DiseasE) Calabria CLI Risk, Prevention and Health Behavior Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1. Toscana EST Molecular, Cellular, and Developmental Neuroscience Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine Istituto Superiore di Sanita' EST Musculoskeletal, Oral Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs. Emilia Romagna CLI EST Healthcare Delivery Noncoding RNAs and cancer IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic Pagina 13 di 31

14 Role of influenza virus infection in the etiopathogenesis of diabetes Sperimentale delle Venezie EST Infectious Diseases and Microbiology Pemphigus vulgaris as a paradigm of autoantibodymediated organ specific autoimmune disorder: pathophysiology and novel tools for diagnosis and therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Musculoskeletal, Oral Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications. Abruzzo EST Oncology 1 Basic Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma Lombardia EST Oncology 1 Basic Early detection and treatment of recurrent, chemotherapyresistant ovarian cancer stem cells by CPE peptide complexed superparamagnetic iron oxide nanoparticles (CPE SPIONs) ISTITUTO TUMORI MILANO EST Oncology HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES: PREVALENCE ANDVIRO IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE IRCCS AOU San Martino IST (Genova) EST Immunology Interleukin 27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg / mice with human immune system GASLINI EST Immunology The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth. C.R.O. AVIANO EST Oncology 1 Basic Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach. MAGGIORE EST Musculoskeletal, Oral Nerve Growth Factor eye drops as a novel treatment for vision loss in patients with Retinitis Pigmentosa: from preclinical to clinical Phase II trial. CLI COF Brain Disorders and Pagina 14 di 31

15 Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multi pathogen detection in ticks and biological samples Sperimentale delle Venezie Veterinary 7, (5) Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE CLI Genes, Genomes and Genetics 7, Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Sperimentale della Lombardia e dell'emilia Veterinary 7, (5) Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models MEDEA Brain Disorders and 7, Role of the meniscus in OA pathology and symptoms RIZZOLI Musculoskeletal, Oral 7, Development of optical methods for preclinical imaging using radiotracers Bioengineering Sciences and Technologies 7, Role of micrornas 143 and 145 in cardiovascular physiology and disease: from bench to bedside MULTIMEDICA Vascular and Hematology 7, Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Piemonte CLI Cardiovascular and Respiratory Sciences 7, MacroH2A1 in the pathogenesis of metabolic syndromeassociated hepatocellular carcinoma CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 7, (4) Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cell based immunotherapy in patients with refractory disease SAN MATTEO CLI Oncology 2 7, Pagina 15 di 31

16 Tailoring the choice of P2Y12 oral receptor blocker by integrating clopidogrel loss of function alleles to phenotype assessment via point of care testing versus standard of care in patients who undergo percutaneous coronary intervention: A randomized mult MAUGERI Cardiovascular and Respiratory Sciences 7, Involvement of micrornas in triple negative breast cancer: from biology to possible therapeutic applications. ISTITUTO TUMORI MILANO EST Oncology 1 Basic 7, (4) Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' CLI Oncology 1 Basic 7, The topological organization of anatomical and functional cortical brain networks in patients with the behavioral variant of frontotemporal dementia and primary progressive aphasia CLI Biobehavioral and Behavioral Processes 7, Deregulation of molecular cross talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment. CASA SOLLIEVO SOFFERENZA EST Oncology 2 7, (4) Fall prevention and locomotion recovery in post stroke patients: a multimodal training towards a more autonomous daily life MAUGERI CLI Musculoskeletal, Oral 7, Health literacy and patient empowerment through the development of an e health information system Istituto Superiore di Sanita' CLI Healthcare Delivery 7, Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anticancer poly peptide vaccine directed against the thymidylate synthase enzyme. Toscana CLI Oncology 2 7, Alteration in cortical parvalbuminergic System in murine model of Huntington s Disease: Pharmacological effect of Phosphodiesterase type 4 (PDE4) inhibition. SANTA LUCIA Brain Disorders and 7, Pagina 16 di 31

17 Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure AUXOLOGICO CLI Cardiovascular and Respiratory Sciences 7, The role of TRAP1 in the resistance to anti EGFR1 agents in human colorectal carcinoma CROB Oncology Definition of the epigenetic signature in Multiple Myeloma by high resolution DNA methylation profiling and integrated analysis with genomic imbalance, gene and microrna expression. CROB Oncology 1 Basic Climate, global drivers and immunodeficiency: effects on the leishmaniosis transmission patterns in Central Italy and appropriate diagnostic flow charts Sperimentale del Lazio e della Toscana Veterinary Development of novel DNA based analytical methods for bacteria detection to improve food safety Sperimentale del Lazio e della Toscana Veterinary Search for novel genes involved in heterogeneous Cryopyrin associated periodic syndromes (CAPS) like autoinflammatory disorders GASLINI Genes, Genomes and Genetics A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' CLI Healthcare Delivery Striatal cholinergic interneurons as a novel target for the treatement of Parkinson's disease Umbria Brain Disorders and Planar haptic device and virtual reality tools for hand and finger rehabilitation S.CAMILLO CLI COF Musculoskeletal, Oral Molecular mechanisms involved in skeletal muscle repair and muscular dystrophy SAN RAFFAELE PISANA Musculoskeletal, Oral Pagina 17 di 31

18 Deleted in Breast Cancer 1, a new player in the DNA damage response. ISTITUTO TUMORI MILANO AREA Sezione Classificazione Oncology 1 Basic Frontal circuit dysfunction as a marker of dementia in parkinsonism NEUROLESI Brain Disorders and Undifferentiated thyroid carcinoma: role of the Twist1 transcription factor SDN Oncology 1 Basic Nanostructured Coatings Enhancing Material Performances in Joint Arthroplasty RIZZOLI Bioengineering Sciences and Technologies New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids SAN MATTEO CLI EST Surgical Sciences, (4) Biomedical Imaging, and Bioengineering EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary (5) High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices Development and preclinical assessment of an innovative endovascular device to occlude prosthetic paravalvular leakage IMMUNOLOGICAL IMPACT OF SILIBININ TREATMENT FOR HCV RECURRENCE IN STABLE LIVER TRANSPLANTED PATIENTS Calabria EST Bioengineering Sciences (4) and Technologies Veneto EST Bioengineering Sciences (4) and Technologies Puglia CLI COF Immunology INVESTIGATION OF THE MOLECULAR BASES OF CARDIOMYOPATHY IN IMMUNOGLOBULIN LIGHT CHAIN (PRIMARY) AMYLOIDOSIS SAN MATTEO Cardiovascular and Respiratory Sciences Pagina 18 di 31

19 Immune gene expression and white matter pathology in first manic patients before and after treatment. A multimodal imaging genetic study Veneto CLI Brain Disorders and Unravelling the genetic basis of limb defects through a combined genomic and functional approach Emilia Romagna Genes, Genomes and Genetics Electronic health databases as a source of reliable information for effective health policy Puglia CLI Healthcare Delivery Toward the development of an in vitro test for ALS: largescale validation of PBMC protein biomarkers Lombardia CLI Brain Disorders and Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction BURLO GAROFALO CLI Vascular and Hematology The endocannabinoid system as a therapeutic target to counteract remote degeneration after spinal cord injury. SANTA LUCIA CLI Brain Disorders and Attention control in complex environments: mechanisms of spatial orienting in the intact and the damaged human brain SANTA LUCIA CLI Integrative, Functional, and Cognitive Neuroscience Optimization of alloreactive natural killer (NK) cell and invariant NKT (inkt) cell mediated anti leukemia effect in children with hematological malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel OSPEDALE BAMBINO GESU' CLI Oncology Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial Piemonte CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Toscana CLI Brain Disorders and Pagina 19 di 31

20 MSC based therapy for the bone marrow and solid organs transplantations Lombardia CLI Oncology Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Toscana CLI Cardiovascular and Respiratory Sciences EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE FATEBENEFRATELLI CLI Healthcare Delivery Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Sicilia CLI Digestive, Kidney and Urological Systems Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Istituto Superiore di Sanita' CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia CLI Oncology 1 Basic 8, Congenital Myopathies: genetic screening starting from a new diagnostic algorithm OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, Oral 8, (4) MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL Toscana CLI Infectious Diseases and Microbiology 8, Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Emilia Romagna CLI Brain Disorders and 8, Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio CLI Brain Disorders and 8, Pagina 20 di 31

21 INNOVATIVE METHOD FOR THE TREATMENT OF TOTAL LIMBAL STEM CELLS DEFICIENCY (LSCD) THROUGH A TISSUE ENGINEERED HEMICORNEA Veneto CLI Bioengineering Sciences and Technologies 8, The contribution of ICT to patient safety in surgical process Emilia Romagna CLI Healthcare Delivery 8, Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department Toscana CLI Healthcare Delivery 8, An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study ARCISPEDALE CLI Healthcare Delivery 8, Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. BURLO GAROFALO CLI Digestive, Kidney and Urological Systems 8, Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow up FATEBENEFRATELLI EST Immunology 8, (4) TARTEGED TREATMENT OF HAIRY CELL LEUKEMIA Umbria CLI Oncology 2 8, Empowering the brain. Induction of Hebbian like plasticity in cortico cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients Lazio EST Brain Disorders and 8, (4) Anosognosia in preclinical and clinical Alzheimer disease as early marker of illness outcome prediction: impact of precocious clinical diagnosis and rehabilitative intervention SANTA LUCIA CLI Brain Disorders and 8, Pagina 21 di 31

22 A machine learning approach to pharmacogenomics. Application to therapy of autoimmune diseases, Myastenia Gravis and Multiple Sclerosis. CARLO BESTA CLI Genes, Genomes and Genetics 8, Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA CLI Brain Disorders and 8, Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies Istituto Superiore di Sanita' CLI Infectious Diseases and Microbiology 8, Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 8, Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano CLI Oncology 2 8, LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab I. O. V. CLI Oncology 2 8, Identification of mirnas involved in the regulation of ALK expression in neuroblastoma IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic 8, (4) ROLE OF RIBOFLAVIN TRANSPORTERS IN MOTOR NEURON DISEASES: Genetic analysis of the Brown Vialetto Van Laere and Fazio Londe syndromes and development of potential treatment strategies for motor neuron diseases. MAGGIORE Molecular, Cellular, and Developmental Neuroscience 8, THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Toscana CLI Cardiovascular and Respiratory Sciences 8, DESIGNING MOLECULAR CHAPERONS FOR PROTEINS: A NEW STRATEGY FOR DRUG DISCOVERY IN NEURODEGENERATIVE DISEASES Istituto Superiore di Sanita' Molecular, Cellular, and Developmental Neuroscience 8, Pagina 22 di 31

23 SPES Service for detection of Pre psychoses: from geneenvironment interactions to phenomenology MEDEA Brain Disorders and 8, Disentangling endogenous resident adult cardiac stem cell biology and aging for clinical protocols of myocardial regeneration without cell transplantation Calabria Cardiovascular and Respiratory Sciences 8, Investigating KAP1 mediated epigenetic control of differentiation and function of adaptive immune system Immunology 8, Perinatal life threatening arrhythmias and Sudden Infant death SAN MATTEO Genes, Genomes and Genetics 8, Targeting strategies in Numb defective cancers I.E.O. Oncology 1 Basic 8, Functional and structural changes induced by repetitive transcranial magnetic stimulation on corticostriatal pathway in models of Parkinson s disease and dyskinesia SANTA LUCIA Brain Disorders and 8, Integration of advanced molecular analyses and magnetic resonance imaging for the identification of biomarkers of disease progression in multiple sclerosis. Istituto Superiore di Sanita' Brain Disorders and 8, lipidomic investigations in Multiple Sclerosis: research ofmolecular biomarkers Abruzzo Biological Chemistry and Macromolecular Biophysics 8, MEF promotes stemness in the pathogenesis of gliomas FATEBENEFRATELLI Oncology 1 Basic 8, Hyperthophic cardiomyopathy: new insights from deep sequencing and psycosocial evaluation. Lombardia CLI COF Cardiovascular and Respiratory Sciences 8, UNRESECTABLE IN TRANSIT METASTATIC MELANOMA: ELECTROCHEMO THERAPY VERSUS ELECTROIMMUNOTHERAPY. LOCAL AND SYSTEMIC EFFECTS. PASCALE CLI COF Oncology 2 8, Pagina 23 di 31

24 Modulation of calcium release activated calcium modulator 1 (ORAI 1) and Stromal interaction molecule 1 (STIM1) activity as a new therapeutical strategy in stroke SAN RAFFAELE PISANA Brain Disorders and 8, A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. MAGGIORE CLI Brain Disorders and 8, A combination of surveys, spatial analyses and molecular epidemiology to get an insight of pre harvest risks from Shiga toxin producing Escherichia coli. Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary (5) Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Sperimentale della Lombardia e dell'emilia Veterinary (5) CERVICAL PLETHYSMOGRAPHY: A NEW TOOL FOR NON INVASIVE ASSESSMENT OF CEREBRAL VENOUS RETURN, AND A POSSIBLE SCREENING DEVICE FOR CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY Emilia Romagna CLI COF Vascular and Hematology Porous titanium combined with an osteoinductive hydrogel and cells: an innovative strategy to improve prosthetic implants osteointegration GALEAZZI COF Musculoskeletal, Oral Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Lazio CLI Population Sciences and Epidemiology METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER SDN CLI Digestive, Kidney and Urological Systems DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna CLI Healthcare Delivery Pagina 24 di 31

25 Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche AREA Sezione Classificazione CLI Population Sciences and Epidemiology Manufacturing information of orthopedic articular prosthesis. Analysis of specific safety issues for radiotherapy, magnetic resonance, orthopedic surgery and identification of a traceability model. Emilia Romagna CLI Healthcare Delivery A randomized controlled trial of diet and physical activity in BRCA mutation carriers ISTITUTO TUMORI MILANO CLI Risk, Prevention and Health Behavior BORON NEUTRON CAPTURE THERAPY (BNCT) IN CUTANEOUSRECURRENCES OF BREAST CANCER: THE DIAGNOSTIC AND THERAPEUTICUTILITY OF 18F FBPA PET/CT I. O. V. CLI Oncology The Lausanne Trilogue Play used as a psychodiagnostic and therapeutic tool in a Neuropsychiatric Unit: an innovative clinical experience working with psychitric children and adolescent Veneto CLI Risk, Prevention and Health Behavior Systematic review on the interventions to reduce waiting lists for elective procedures Emilia Romagna CLI Healthcare Delivery Supporting an early autism spectrum disorders diagnosis through the support vector machine approach STELLA MARIS CLI Brain Disorders and Early Detection in Autism Spectrum Conditions STELLA MARIS CLI Brain Disorders and IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA CLI Healthcare Delivery Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments MONDINO CLI Healthcare Delivery Pagina 25 di 31

26 IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE Emilia Romagna CLI Digestive, Kidney and Urological Systems PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Lombardia CLI Risk, Prevention and Health Behavior Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery SANTA LUCIA CLI Brain Disorders and Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano CLI Healthcare Delivery The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Emilia Romagna CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI CLI Surgical Sciences, Biomedical Imaging, and Bioengineering Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] Lazio CLI Cardiovascular and Respiratory Sciences Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto CLI Infectious Diseases and Microbiology MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR CLINICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME HUMANITAS CLI Integrative, Functional, and Cognitive Neuroscience Pagina 26 di 31

27 Longitudinal clinical neuropsychological study of subjective memory complaints Toscana CLI Brain Disorders and 9, Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease MAUGERI CLI Brain Disorders and 9, Evaluation of extrapyramidal involvement in amyotrophic lateral sclerosis (ALS): a prospective cohort survey Piemonte CLI Brain Disorders and 9, Improved pre surgical evaluation of the human epileptogenic zone with a novel intracranial recording/analysis platform CARLO BESTA COF Brain Disorders and 9, Individualized treatment of patients with advanced NSCLC: potential application for Circulating Tumor Cells (CTC) molecular and phenotypical profiling I. O. V. CLI Oncology 2 9, A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Sperimentale della Sicilia Veterinary 9, (5) FEASIBILITY AND COST EFFECTIVENESS OF A MULTIDISCIPLINARY HOME TELEHEALTH INTERVENTION PROGRAMME TO REDUCE FALLS AMONG ELDERLY DISCHARGED FROM HOSPITAL: A PILOT RANDOMIZED CONTROLLED TRIAL MAUGERI CLI Risk, Prevention and Health Behavior 9, Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Sperimentale della Sardegna Veterinary 9, (5) THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia CLI Brain Disorders and 9, Optimization of the clinical management of endocrineresponsive early breast cancer patients IRCCS AOU San Martino IST (Genova) CLI Oncology 2 9, Pagina 27 di 31

28 Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Friuli Venezia Giulia CLI Healthcare Delivery 9, EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: CLINICAL/REHABILITATIVE IMPLICATIONS FOR DISERS OF SPATIAL ATTENTION IN STROKE PATIENTS SANTA LUCIA CLI Brain Disorders and 9, Soluble biomarkers predicting coronary bypass graft patency MONZINO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering 9, Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets PASCALE CLI Oncology 2 9, Telemedicine Services for UTAP Veneto CLI Healthcare Delivery 9, Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Emilia Romagna CLI Oncology 2 9, Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Emilia Romagna CLI Population Sciences and Epidemiology 9, Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Toscana CLI Healthcare Delivery 9, Screening of children at risk for language and communication disorders Lazio CLI Biobehavioral and Behavioral Processes 9, Food irradiation: quality and detection of plant origin food with health benefits Sperimentale della Puglia e della Basilicata Veterinary 9, (5) Pagina 28 di 31

29 EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO CLI Healthcare Delivery 9, Prognostic marker of cytomegalovirus infection and transmission in pregnancy. Emilia Romagna CLI Infectious Diseases and Microbiology 9, ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna CLI Brain Disorders and 9, An intervention aimed at improving the cognitive, physical, and psychiatric functioning of patients with Mild Cognitive Impairment: A randomized control trial of physical exercise and cognitive stimulation. Lazio CLI Risk, Prevention and Health Behavior 9, Development and optimization of a dedicated selfshielded system to perform accelerated partial breast irradiation in prone position after breast conserving surgery. REGINA ELENA CLI COF Oncology Cancer biomarker detection using micro structured/superhydrophobic surfaces and advanced spectroscopy techniques Calabria COF Bioengineering Sciences and Technologies Cost Utility of Conventional Hemodialysis (CHD) versus Short Daily Hemodialysis (SDHD) for patients coming from Automated Peritoneal Dialysis (APD): A randomized controlled trial Puglia CLI COF Healthcare Delivery A new automatic device for personalized clinical monitoring of thrombotic and hemorraghic risk assessment in cancer patients C.R.O. AVIANO COF Oncology Development of brain targeted epigenetic drugs for the treatment of neurodegenerative disorders and brain ischemia S.CAMILLO COF Brain Disorders and Pagina 29 di 31

30 Role of SAMITAL in prevention of chemo radiation (CT/RT) induced oral mucositis in cancer patients. A Phase 2 Randomized Controlled trial in adults and a feasibility study in paediatric patients I. O. V. CLI COF Oncology Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary (5) Assessing antibiotic resistance in nonpathogenic foodrelated bacteria: the impact on human gut microbiota Sperimentale delle Venezie Veterinary 10, (5) Campylobacter, L. monocytogenes and Verocytotoxinproducing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Sperimentale dell'abruzzo e del Molise Veterinary 10, (5) Molecular determination of Salmonella serovars by using microsphere based suspension array Sperimentale delle Venezie Veterinary 10, (5) DOSE WARPING METHODS FOR IGRT AND ADAPTIVE RT: DOSE ACCUMULATION BASED ON ORGAN MOTION AND ANATOMICAL VARIATIONS OF THE PATIENTS DURING RADIATION THERAPY TREATMENTS Emilia Romagna COF Oncology 2 10, ß amyloid control of peripheral and neuronal glucose uptake NEUROMED COF Brain Disorders and 10, An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Sperimentale dell'umbria e delle Marche Veterinary 10, (5) FREMS for Acute Inflammatory Bowel Disease: a Phase I/II Clinical trial Lazio CLI COF Digestive, Kidney and Urological Systems 10, Pagina 30 di 31

31 Sebum lipidomics: a new tool to correlate skin and systemic lipid metabolism. SAN GALLICANO COF Musculoskeletal, Oral LEGENDA : NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso anche se in altra sezione NOTA 4 = Progetto Giovane Ricercatore Estero Finanziato in quanto con punteggio uguale od inferiore a 8,5 score Limite Finanziamento GR NOTA 5 = Progetto Finanziato per riserva Veterinaria/Sicurezza Alimentare Pagina 31 di 31