Ministero della Salute

Transcription

1 Ministro dlla Salut Dirzion Gnral dlla Ricrca dll' Innovazion in Sanità BANDO 2013 PROGETTI ORDINARI RF GRADUATORIA PROGETTI Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt and implant of th photovoltaic artificial rtina in th pig with photorcptor dgnration: towards th human Phas 1 xprimntation Vnto Biomdica Bionginring Scincs and Tchnologis 5, Dfining molcular targts that govrn th capacity of platlts to support hpatitis B virus (HBV) associatd livr immunopathology SAN RAFFAELE MILANO Biomdica Immunology 5, ASSESSMENT OF THE PATHOBIOLOGICAL ROLE, DIAGNOSTIC AND PREDICTIVE VALUE OF THE NOVEL CYTOKINE IL 30 IN PROSTATE CANCER Abruzzo Biomdica Oncology 1 Basic Translational 5, Targting mitochondrial calcium handling in cor myopathis: an intgrativ approach towards novl thraputic stratgis Vnto Biomdica Musculoskltal, Oral and Skin Scincs 5, A NOVEL INTEGRATED GENOMIC AND IMMUNOLOGICAL STRATEGY FOR THE THERAPY OF CHRONIC HEPATITIS B Emilia Romagna Biomdica Immunology Pagina 1 di 228

2 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prnylcystin Lyas as a potntial novl playr in athrosclrosis MONZINO Biomdica Vascular and Hmatology 6, Th long pntraxin PTX3 in cancr: a novl playr in cancr rlatd inflammation HUMANITAS Biomdica Immunology 6, Rol of th p21 mdiatd DNA Damag Rspons in th immun survillanc of lukmia stm clls I.E.O. Biomdica Oncology 1 Basic Translational 6, CarToy: a smart Systm for arly hombasd intrvntion in infants at high risk for Crbral Palsy STELLA MARIS Clinicoassistnzial Brain Disordrs and Nuroscinc 6, NETosis in athrothrombotic disordrs Vnto Biomdica Vascular and Hmatology 6, Rab39b mous modls: pr clinical studis by using AMPA rcptors as possibl thraputic targts to unravl th rol of RAB39B in Intllctual Disability and Autism Spctrum Disordr SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc 6, No mor mrgncis in DNA spcis idntification: dvlopmnt and harmonization of molcular and nxt gnration mthods to dtrmin and quantify origin spcis in food and to discriminat frauds from unintntional contamination. IZSPLV Biomdica Vtrinary 6, Pagina 2 di 228

3 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt of a nanoparticl basd pharmacological approach for amyotrophic latral sclrosis MARIO NEGRI Biomdica Brain Disordrs and Nuroscinc Cll typ and subunit spcific altrations of NMDA rcptors in striatum at arly stags of Parkinson's disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Pancratic cancr thrapy basd on combination of DNA vaccination and PI3Kgammainhibition Pimont Biomdica Immunology BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY BACTERIOVORAX SPECIES. IZSUM Biomdica Vtrinary NSD1 PHD fingrs as potntial targts for Acut Myloid Lukmia SAN RAFFAELE MILANO Biomdica Biological Chmistry and Macromolcular Biophysics An intgratd approach to unravl th gntic causs and molcular pathognsis of pilptognic focal cortical dysplasia. Toscana Clinicoassistnzial Brain Disordrs and Nuroscinc 7, Vitamin E, mirna and inflammation: a tunabl ntwork in Alzhimr's disas. Umbria Biomdica Brain Disordrs and Nuroscinc 7, Pagina 3 di 228

4 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Distinct dvlopmntal programs of cord blood and bon marrow hamatopoitic stm clls rconstitut diffrnt B cll compartmnts in transplantd patints lading to transplant spcific immun impairmnt. Cllular and molcular charactrization of transi OSPEDALE BAMBINO GESU' Biomdica Immunology 7, Olfaction as an indx of convrsion from MCI to AD: a longitudinal functional connctivity study Emilia Romagna Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 7, Crvical cancr scrning in youngr womn. Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis 7, Rol of srotonin in modulating L DOPA inducd dyskinsia SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 7, MICRORNA IN PAPILLARY THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 7, Validation of a novl non invasiv tchniqu basd on ral tim ultrasound B mod to assss th jugular vnous puls Emilia Romagna Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 7, Modulation of visuospatial awarnss during multi tasking in right hmisphr strok patints: towards novl bhavioral and nurofunctional prdictors of impairmnt and rcovry of th attntional ntworks S.CAMILLO Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 7, Pagina 4 di 228

5 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not APRON: Assay for PRiONs. DEVELOPMENT OF AN ASSAY DETECTING PRIONS IN ANIMALS AND HUMANS AFFECTED WITH PRION DISORDERS IN A PRECLINICAL AND CLINICAL STAGE IZSPLV Biomdica Vtrinary 7, LEFT VENTRICULAR HYPERTROPHY IN AORTIC VALVE DISEASE AND HYPERTROPHIC CARDIOMYOPATHY: GENETIC BASIS, BIOPHYSICAL CORRELATES AND VIRAL THERAPY MODELS Toscana Clinicoassistnzial Cardiovascular and Rspiratory Scincs 7, Inhibition of ndocannabinoidshydrolyzing nzyms as a nw thraputic targt for migraintratmnt: studis in animal modls and prliminary valuation in humans MONDINO Biomdica Brain Disordrs and Nuroscinc 7, Nuroplasticity and Alzhimr's disas: intgratd approach to idntify biological and nurophysiological markrs. FATEBENEFRATELLI Biomdica Brain Disordrs and Nuroscinc 7, Targtting th intrlukin 6 rcptor as a novl thraputic approach in Duchnn muscular dystrophy to modulat muscl inflammation and rgnration OSPEDALE BAMBINO GESU' Biomdica Musculoskltal, Oral and Skin Scincs 7, Pagina 5 di 228

6 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Calcitonin oligomrs as a modl to study th amyloid nurotoxicity: th focal rol playd by lipid rafts in th prvntion and cur. Istituto Suprior di Sanita' Biomdica Biological Chmistry and Macromolcular Biophysics 7, Rol of nvironmnt gn intraction in tiology and promotion of pituitary tumours. Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 7, R organization of nural circuits bfor mmory loss in mic modls of Alzhimr s disas: xprimntal approach of th cognitiv rsrv concpt and implications for diagnosis and thrapy SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro suprior a (Valutazion F2F compltato SCIENTIFIC QUALITY : 2 METHODOLOGY : 1,5 NOVELTY : 1,5 MERIT : 1,5 FACILITY : 1,5) Idntification of biological and imaging vnts that prdict th progrssion of Takayasu artritis vascular lsions SAN RAFFAELE MILANO Clinicoassistnzial Immunology Effct of surgical or consrvativ approach in patints with adrnal incidntalomas on cardiovascular, mtabolic, nuropsychological and bon manifstations: rspctiv rols of cortisol scrtion and glucocorticoid snsitivity. MAGGIORE Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 6 di 228

7 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Sroprvalnc of Hpatitis E virus infction in Italian blood donors: a survy at national and rgional lvl Istituto Suprior di Sanita' Biomdica Population Scincs and Epidmiology Posizion Sub RankingN.1 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 1 METHODOLOGY: 2,5 NOVELTY : 1,5 MERIT : 1,5 FACILITY : 1,5) Cardiac amyloidosis: molcular mchanism and innovativ thrapis for a challnging aging rlatd cardiomyopathy SAN MATTEO Biomdica Biological Chmistry and Macromolcular Biophysics Posizion Sub Ranking N.2 RF Biomdici con scor a 8 (La Study Sssion ha assgnato il valor proposto nl F2F Forum nlla proposta di F2F com valor final prtanto gli scor dll vari voci nlla proposta di F2F valida sono i sgunti SCIENTIFIC QUALITY : 1,5 METHODOLOGY: 1,5 NOVELTY : 2 MERIT : 1,5 FACILITY : 1,5) Effcts of matrnal nutrition during prgnancy on ftal pigntic profil: st up of a rsarch infrastructur. MAGGIORE Biomdica Halthcar Dlivry and Mthodologis Posizion Sub Ranking N.3 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 1,5 METHODOLOGY: 1,5 NOVELTY : 2,5 MERIT : 1,5 FACILITY : 1) Pagina 7 di 228

8 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Inhibition of Glycolysis by 2 Doxy D Glucos as a Thraputic Stratgy for Polycystic Kidny Disas SAN RAFFAELE MILANO Biomdica Digstiv, Kidny and Urological Systms Posizion Sub Ranking N.4 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 1,5 METHODOLOGY : 2 NOVELTY : 1,5 MERIT : 1,5 FACILITY : 1,5) Rol of xtracllular vsicls in bon tumour pathognsis: implications for thrapy OSPEDALE BAMBINO GESU' Biomdica Musculoskltal, Oral and Skin Scincs Posizion Sub Ranking N.5 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 1,5 METHODOLOGY : 2,5 NOVELTY : 1,5 MERIT : 1,5 FACILITY : 1) Idntification of nw thraputical targts of cancr stm clls: study of th mchanistics of mitotic spindl alignmnt to cortical polarity in mammary stm cll asymmtric divisions I.E.O. Biomdica Biological Chmistry and Macromolcular Biophysics Posizion Sub Ranking N.6 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY : 1 NOVELTY : 2 MERIT : 1,5 FACILITY : 1,5) Mothr child immunogntic intractions in prgnancy and risk of Autism Spctrum Disordrs DON GNOCCHI Biomdica Brain Disordrs and Nuroscinc Posizion Sub Ranking N.7 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY : 1,5 NOVELTY : 2 MERIT : 1,5 FACILITY : 1) Pagina 8 di 228

9 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Assssmnt of th thraputic valu of targting cancr stm clls in Numbdficint brast cancr. I.E.O. Biomdica Oncology 1 Basic Translational Posizion Sub Ranking N.8 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY : 2 NOVELTY : 1,5 MERIT : 1 FACILITY : 1,5) Conncting DNA rpair and mtabolic altrations of obsity in a sarch for prdictiv biomarkrs Istituto Suprior di Sanita' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Posizion Sub Ranking N.9 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY : 2 NOVELTY : 2 MERIT : 1 FACILITY : 1) Impact of short trm fasting cycls on th fficacy of chmothrapy to trat pancratic cancr CASA SOLLIEVO SOFFERENZA Biomdica Oncology 1 Basic Translational Posizion Sub Ranking N.10 RF Biomdici con scor a 8 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY : 2,5 NOVELTY : 1,5 MERIT : 1 FACILITY : 1) A nw immunothrapy option for oral mlanoma and othr canin malignant tumors using a DNA vaccin coding for human chondroitin sulphat protoglycan 4 (CSPG4), intgratd with th validation of candidat gn usful for thraputic opportunitis and prog IZSPLV Biomdica Vtrinary 8, Finanziato pr risptto vincolo minimo progtti IZS Pagina 9 di 228

10 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th prognostic valu of collatral flow in acut ischmic strok scondary to occlusion of intracranial artris tratd by ndovascular thrapy. SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc 8, Rspiratory Syncytial Virus (RSV) infction in infants: th Ectont/IFNs axis as rgulator of inflammatory/adaptiv rsponss and as thraputic targt. Istituto Suprior di Sanita' Biomdica Immunology 8, Typ 4 Phosphodistrass as novl targts to rduc cardiovascular comorbiditis in COPD. Abruzzo Biomdica Cardiovascular and Rspiratory Scincs 8, INSIDE: INtgratd in SIlico and in vivo approach to uncovr th hiddn gntic basis of GnRH nuron DEficincy AUXOLOGICO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 8, Nurons drivd from inducd pluripotnt stm clls from multipl sclrosis patints as a tool for studying pathognic disas mchanisms and idntifying novl nuroprotctiv compounds SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc 8, Pharmacological targting of brain 5HT7 rcptor to rscu molcular, morphofunctional and bhavioral dficits in prclinical modls of Rtt Syndrom Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 8, Pagina 10 di 228

11 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th Impact of Hypoxia and MicroRNA Control on Dystrophin associatd Protin Complx (DPC )protins during Nuronal Diffrntiation: Implications for Cognitiv Dficits in Duchnn Muscular Dystrophy Istituto Suprior di Sanita' Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 8, Innovativ mthods for autologous pancratic bta clls and psudo islts production. MULTIMEDICA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 8, Manipulat cytokins to shift th chronic inflammatory ton inducd by prion disas as a rout to clinical thrapis HUMANITAS Biomdica Immunology 8, Dvlopmnt of an in vitro modl systm basd on clonal amniotic fluid stm clls for disscting th pigntic mchanisms undrlying pathognsis of Kabuki syndrom MAGGIORE Biomdica Biology of Dvlopmnt and Aging 8, SELECTIVE AXILLARY LYMPH NODE DISSECTION VS COMPLETE AXILLARY DISSECTION: A RANDOMISED CLINICAL TRIAL TO ASSESS THE PREVENTION OF LYMPHEDEMA IN BREAST CANCER TREATMENT ISTITUTO TUMORI MILANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 8, Th rol of Cardiac Ankyrin Rpat Protin in cardiac inflammatory pathways and rmodling associatd with human dilatd, hyprtrophic, and post inflammatory cardiomyopathy. HUMANITAS Biomdica Cardiovascular and Rspiratory Scincs Pagina 11 di 228

12 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Subthalamic nuclus dp brain stimulation in Tourtt syndrom CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc Effcts of diffrnt ditary fatty acids on non alcoholic fatty livr disas in patints with typ 2 diabts Campania Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Elucidating molcular and functional intractions btwn stroids and histon dactylas inhibitors in th tratmnt of nuromuscular disordrs SANTA LUCIA Biomdica Musculoskltal, Oral and Skin Scincs Axillary Rvrs Mapping (ARM).Try to idntify and spar lymphatic pathways in brast cancr surgry to prvnt brast cancr rlatd lymphdma (BCRL) Emilia Romagna Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Molcular undrstanding of E3 ligass involvd in signaling and cancr I.E.O. Biomdica Biological Chmistry and Macromolcular Biophysics TAVI vrsus Suturlss for th tratmnt of svr aortic stnosis in high risk patints: a multicntr prospctic randomizd study Emilia Romagna Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Novl thraputic approachs to slow muscular dystrophy progrssion: idntification ofpotntial targts through molcular dissction of th altrations in mitochondrial biognsisand in its pigntic control Lombardia Biomdica Musculoskltal, Oral and Skin Scincs Pagina 12 di 228

13 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th complmnt and coagulation systms: contribution to ischmia and microthrombosis in subarachnoid hmorrhag MAGGIORE Biomdica Brain Disordrs and Nuroscinc Early athrosclrosis in patints with statosis and with chronic hpatitis C: rol of viscral adiposity, procoagulant imbalanc and ndothlial dysfunction in vascular damag MAGGIORE Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs TOWARDS A PRECISION MEDICINE APPROACH TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE SAN MATTEO Biomdica Cardiovascular and Rspiratory Scincs Altration of lipoprotins in HIVinfctd patints: implications for cardiovascular disas. SPALLANZANI Biomdica AIDS and Rlatd Rsarch OPA1 rlatd blindnss in Italy: from gnotyp to phnotyp to disas modlling, towards a thrapy Istituto Scinz Nurologich Biomdica Brain Disordrs and Nuroscinc Virtual Rality Simulator and Computr Guiding Systm for ndoscopic and robotic platforms Lombardia Biomdica Halthcar Dlivry and Mthodologis Dtction of vctor born viruss in Sardinia by mtagnomics and valuation of Blutongu virus volution IZSAM Biomdica Vtrinary Pagina 13 di 228

14 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Anti Cholinrgic rcptors antibodis, HUMANITAS cardiovascular autonomic profil and dysautonomia symptoms rlationships in Pur Autonomic Failur, Amyotrophic Latral Sclrosis and Postural Orthostatic Tachycardia Syndrom: vidnc for a pathophysiology basd th Clinicoassistnzial Cardiovascular and Rspiratory Scincs ALS and FTD: changing paradigms in th gnotyp phnotyp corrlation du to C9orf72 and othr gn charactrization AUXOLOGICO Clinicoassistnzial Brain Disordrs and Nuroscinc A packaging sirna nanothraputic approach addrssing a causal dfct of dopaminrgic nurons to arrst nigrostriatal dgnration in xprimntal Parkinson's disas Associazion Oasi Maria SS Biomdica Brain Disordrs and Nuroscinc Ghrlin as a nw cardiomtabolic risk biomarkr: from population and patint studis to tissu and cll biology in hart and skltal muscl. Friuli Vnzia Giulia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS Lombardia Biomdica 9, Disscting Kabuki syndrom by cllular modlling and gnom wid analysis CASA SOLLIEVO SOFFERENZA Biomdica Gns, Gnoms and Gntics 9, From micro GIST to ovrt GIST: dissction of th molcular altrations involvd in GISTmalignant volution C.R.O. AVIANO Biomdica 9, Pagina 14 di 228

15 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Validation of th histon dmthylas LSD1 as a targt in acut myloid lukmia I.E.O. Biomdica Oncology 1 Basic Translational 9, Bridging th gap btwn molcular mchanism and clinical trial, a promising approach to spinocrbllar ataxias sharing Purkinj nurons dark dgnration SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc 9, Calcium Calmodulin Kinass mdiatd rgulation of human athrosclrotic plaqus: rol in vascularwall and infiltrating inflammatory clls Campania Biomdica Cardiovascular and Rspiratory Scincs 9, Endocannabinoids and growth factors cross talk in th procss of wound haling SAN GALLICANO Biomdica Cll Biology 9, rlvanc of constitutional nontruncating mutations in APC gn: an intgratd analysis to dfin th association btwn variants of uncrtain significanc and gntic risk of colo rctal polyposis and cancr C.R.O. AVIANO Biomdica Oncology 1 Basic Translational 9, ROLE OF THE NEUROTROPHIN BDNF AND ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS MONZINO Biomdica Vascular and Hmatology 9, Hydrogn Sulfid rol in th inflammatory rspons in Amyotrophic Latral Sclrosis SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 9, Pagina 15 di 228

16 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idiopathic Normal Prssur Hydrocphalus (inph), parkinsonism and dmntia: improving th accuracy of diagnosis and th patint car to rvrs th symptomatology MONDINO Clinicoassistnzial Brain Disordrs and Nuroscinc 9, Nurodgnration, Phnotyps and Outcom Masurs Chromosom 17 gn amplification hotspots as biomarkrs and thraputic targts for aggrssiv brast cancr. I.E.O. Biomdica Oncology 1 Basic Translational 9, GUT MICROBIOTA AND INFLAMMASOME IN THE PATHOGENESIS OF ALZHEIMER S DISEASE DON GNOCCHI Biomdica Brain Disordrs and Nuroscinc 9, Towards prcision mdicin for patints with biliary tract cancrs: tailord tratmnts basd on th mutational profil dtctd on tumor lsions and monitord in liquid biopsis (circulating tumor clls, CTC, and circulating tumor DNA, ctdna) ISTITUTO TUMORI MILANO Clinicoassistnzial 9, EARLY STUDY. MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEENEARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. Pimont Clinicoassistnzial Cardiovascular and Rspiratory Scincs 9, Pagina 16 di 228

17 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Omga 3 basd nutracuticals as modulators of ndocannabinoid signaling: a potntial stratgy for mchanistic undrstanding and managmnt of Alzhimr's disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 9, Rport AGE Projct: clinical and biological prdictors of physical function dclin in oldr patints with chronic cardiovascular disass I.N.R.C.A. Clinicoassistnzial Biology of Dvlopmnt and Aging 9, Novl approachs for scrning of humoral primary immunodficincis in adult patints Toscana Clinicoassistnzial Immunology 9, MECHANISMS CONTROLLING COGNITIVE IMPAIRMENT IN MORBIDLY OBESE PATIENTS Lazio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 9, Dvlopmnt of nw tchnologis to promot thymic rgnration for th tratmnt of Primary Immunodficincis SAN RAFFAELE MILANO Biomdica Gns, Gnoms and Gntics 9, Analytical dtrmination and xposur assssmnt of nanomatrials in food Istituto Suprior di Sanita' Biomdica Vtrinary 9, Hrditary Spastic Paraplgia: sarch for disas gns by a ntwork basd approach SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 9, P2X ionotropic rcptors as thraputic targts in dystrophin and sarcoglycan dficint muscular dystrophis GASLINI Biomdica Musculoskltal, Oral and Skin Scincs 9, Pagina 17 di 228

18 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Innovativ stratgis to harnss th immun systm against cancr with bispcific antibodis Lombardia Biomdica 9, Improving thraputic appropriatnss of Multipl Sclrosis tratmnts using biological approachs to prsonaliz thrapy and sav pharmacutical spnding Pimont Clinicoassistnzial Brain Disordrs and Nuroscinc 9, Effcts of multimodal training on cognition, biomarkrs, rs FMRI and brain structural intgrity in MCI patints Abruzzo Clinicoassistnzial Brain Disordrs and Nuroscinc Crop biofortification with iodin: a nw tool to fight iodin dficincy disordrs. Toscana Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Gnom basd dvlopmnt of nw diagnostic, virulnc and pidmiological markrs for nontubrculous mycobactria Emilia Romagna Biomdica Infctious Disass and Microbiology Gntic dissction of cystic fibrosis host suscptibility to Psudomonas aruginosa infctions using a highly gntically divrs mous rsourc population, th Collaborativ Cross mic SAN RAFFAELE MILANO Biomdica Infctious Disass and Microbiology Epidmiology of strok in th L'Aquila district Abruzzo Clinicoassistnzial Population Scincs and Epidmiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Pagina 18 di 228

19 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Mitochondrial dysfunction and iron (dys) mtabolism in Nurodgnration with Brain Iron Accumulation (NBIA): an intgratd approach basd on human nuronal cllular systms CARLO BESTA Biomdica Brain Disordrs and Nuroscinc A nw potntial thraputic for Rtt Syndrom: a prclinical study Istituto Suprior di Sanita' Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc NEUROPHYSIOLOGICAL AND OPTOGENETIC ASSESTMENT OF SYNAPTIC PLASTICITY IN DYT11 DYSTONIA SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Caffin as a potntial thraputic option for Alzhimr's disas Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc Gntic and antignic divrsity and pathognicity of viruss associatd with ntritis Emilia Romagna Biomdica Infctious Disass and Microbiology Multipl and inducibl gn thrapy for Pimont Biomdica Bionginring Scincs and improving priphral nrv rgnration. Tchnologis Th gntics of suddn cardiac dath in athlts and implication for risk prvntion Vnto Clinicoassistnzial Cardiovascular and Rspiratory Scincs Rol of th Transcriptional Rprssor REST/NRSF in Nuroinflammation HUMANITAS Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Svn Tsla MR imaging as prclinical biomarkr in populations at risk for Parkinson disas Toscana Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 19 di 228

20 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ar gntic, inflammatory and mtabolomic markrs of coronary hart disas rlatd to kidny function dclin in patints with typ 2 diabts? CASA SOLLIEVO SOFFERENZA Clinicoassistnzial Population Scincs and Epidmiology Gntic and pigntic mchanisms in Clustr Hadach: gnomic and plasma xosom mirna studis Emilia Romagna Biomdica Brain Disordrs and Nuroscinc Multicntr phas II clinical study of adoptiv immunothrapy with alloractiv NK clls as consolidation stratgy for ldrly acut myloid lukmia patints Emilia Romagna Clinicoassistnzial Mutatd calrticulin as a novl diagnostic markr and thraputic targt in chronic myloprolifrativ noplasms Toscana Biomdica Idntifying prclinical phnotypic and biological markrs of Alzhimr's Disas in halthy ldrly at risk subjcts SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmnt of human Msnchymal Stm Cll drivn bon marrow micronvironmnts/nichs supporting hmopoisis and controlling hmatopoitic and non hmatopoitic tumor growth in vivo IRCCS AOU San Martino IST (Gnova) Biomdica Cll Biology OstoCHONdral tissu REGENration by a novl anti INflammatory bi phasic scaffold (CHONREGENIN) GALEAZZI Biomdica Musculoskltal, Oral and Skin Scincs Pagina 20 di 228

21 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not and Exprimntal Pathway to Vitiligo Managmnt SAN GALLICANO Clinicoassistnzial Musculoskltal, Oral and Skin Scincs A comprhnsiv NGS basd approach for th dfinition of th molcular bass of th hrditary dysmylinating disordrs of th cntral nrvous systm CARLO BESTA Biomdica Gns, Gnoms and Gntics A novl playr in ovarian cancr vasculatur: biological rol and thraputic implications I.E.O. Biomdica Oncology 1 Basic Translational Vitamin D Supplmntation on Assistd Rproduction Tchnology (ART) outcoms: a randomizd clinical controlld trial and an invstigation of th involvd biological mchanisms MAGGIORE Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Discovring mtabolomic signaturs associatd with spcific gn mutations in mlanoma and thir rol in tumor radiosnsitivity and immunognicity. Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational utility of a nxt gnration squncing basd "oncochip" for thraputic dcision in mtastatic brast cancr I.E.O. Clinicoassistnzial Assssmnt of th risk for consumrs xposd to palytoxins contaminatd safood in th prsnc of Ostropsis cf. ovata bloom along th Italian coasts Istituto Suprior di Sanita' Biomdica Vtrinary Pagina 21 di 228

22 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prvnting mntal rtardation in two intrmdiat mtabolism disass: a prclinical invstigation for nw thrapy SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc A novl structural and functional MRIdrivd indx of axonal mylination: application to MS and corrlation with nurophysiology SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Nanoparticl dpndnt dlivry of stroids for th tratmnt of primary biliary cirrhosis to incras thir thraputic indx HUMANITAS Biomdica Digstiv, Kidny and Urological Systms 10, METABOHEARTFAIL GRAPE mirnas IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN 7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON ISCHEMIC CHRONIC HEART FAILURE Toscana Biomdica Cardiovascular and Rspiratory Scincs 10, Extracllular vsicls in th crosstalk btwn adipocyts and pancratic btaclls: link with obsity and diabts. Pimont Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 10, Rol of Extra virgin oliv oil in modulating post prandial oxidativ strss in Diabtic patints Lazio Clinicoassistnzial Risk, Prvntion and Halth Bhavior 10, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Pagina 22 di 228

23 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Changs in post transcriptional gn rgulation in ALSdu to xpansion of th c9orf72 rpats SANTA LUCIA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 10, BRIDGING THE TUMOR MACRO AND MICRO ENVIRONMENT: THE ROLE OF METABOLIC AND NEUROENDOCRINE FACTORS IN BREAST CANCER PROGRESSION Istituto Suprior di Sanita' Biomdica Biobhavioral and Bhavioral Procsss 10, Protostasis modulation as a novl thraputic stratgy for cystic fibrosis. GASLINI Biomdica Gns, Gnoms and Gntics 10, FTD gnotyp phnotyp corrlation in two population clustrs with common gntic background living in diffrnt continnts. Calabria Biomdica Brain Disordrs and Nuroscinc 10, Computr Assistd Evaluation of Fractur Risk in Tumor Spin Lsions RIZZOLI Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 10, Pharmacogntic modulation of Ras ERK signalling in mous modls of striatal nurodgnration and cognitiv dclin SAN RAFFAELE MILANO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 10, Targting hmatological malignancis by TCR gn ditd mmory stm T clls SAN RAFFAELE MILANO Biomdica 10, Multilinag diffrntiation of limbal stm clls for rgnrativ mdicin. Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 10, Pagina 23 di 228

24 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rgulation of SMN2 splicing in cll and mous modls of Spinal Muscular Atrophy SANTA LUCIA Biomdica Gns, Gnoms and Gntics 10, Thrapis for inborn rrors of mtabolism Campania Biomdica Gns, Gnoms and Gntics 10, Intrplay btwn th dcidual micronvironmnt and HLA Gxprssing rgulatory clls in promoting tolranc at th ftal matrnal intrfac. SAN RAFFAELE MILANO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 10, Anti SAP (scrtd aspartyl protinass) antibodis to fight mucosal and systmic candidiasis. Umbria Biomdica Infctious Disass and Microbiology 10, Discovry of Tat mimicking compounds to fight HIV latncy Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch 10, An pigntic stratgy to incras chmosnsitivity in cancr: Malignant Msothlioma as a modl SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational 10, Combining immunomodulatory drugs with standard chmothrapy to rvrt tumor promoting Th2 inflammation in pancratic cancr SAN RAFFAELE MILANO Biomdica Immunology 10, Pain in Parkinson's Disas. A multidisciplinary clinical, nurophysiological and transcranial brain stimulation approach. Vnto Biomdica Brain Disordrs and Nuroscinc 10, Pagina 24 di 228

25 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt of nw biguanids to targt cancr mtabolism IRCCS AOU San Martino IST (Gnova) Biomdica Oncology 1 Basic Translational 10, Occurrnc of Ostropsis gnus blooms in Tyrrhnian sa: tools to prvnt human intoxication du to palytoxins contaminatd safood. Istituto Suprior di Sanita' Biomdica Vtrinary 10, Nw ASIC channl inhibitors for th SAN RAFFAELE MILANO Biomdica Brain Disordrs and tratmnt of chronic nuro inflammation Nuroscinc 10, Computr aidd diagnosis of brain amyloidosis in PET imaging. IRCCS AOU San Martino IST (Gnova) Biomdica Brain Disordrs and Nuroscinc 10, Implmntation of th automatic, SUVRindpndnt scoring systm for EvaLuation of Brain Amyloidosis (ELBA) in two groups of subjcts, having maximum (i.., patints with crtifid Alzhimr's PYB Protct Your Back (Effctivnss of Back Protctor in prvnting spinal cord injuris) Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior 10, Invstigating th molcular mchanisms lading to gnom instability in tumours: analysis ofrol of th rplication strss rspons and its potntial for arly diagnosis and targt thrapy of cancr Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational 10, Pagina 25 di 228

26 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Alcohol rlatd nurodvlopmntal disordrs: prvntion and arly diagnosis of ftal alcohol spctrum disordrs and ftal alcohol syndrom. Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior 10, Association btwn childhood xposur to phthalats and bisphnol A, subclinical hypothyroidism and cardiomtabolic risk OSPEDALE BAMBINO GESU' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 10, Idntification of innovativ thraputic stratgis rgarding mtastatic ovarian cancrs Sicilia Biomdica 10, Molcular charactrization of pulmonary sarcomatoid carcinoma, a dadly subtyp of lung cancr, for patint managmnt ISTITUTO TUMORI MILANO Clinicoassistnzial Gns, Gnoms and Gntics 10, Posizion Sub Ranking N 1 RF Clinico assistnzial con scor a 10,5 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY: 2 NOVELTY : 2,5 MERIT : 2 FACILITY : 2) Pagina 26 di 228

27 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Pathophysiology of fatigu in Parkinson's disas and ffct of arobic rhabilitation SAN RAFFAELE PISANA Clinicoassistnzial Brain Disordrs and Nuroscinc 10, Posizion Sub Ranking N 2 RF Clinico assistnzial con scor a 10,5 (La Study Sssion ha assgnato il valor proposto nl F2F Forum nlla proposta di F2F com valor final prtanto gli scor dll vari voci nlla pèroposta di F2F valida sono i sgunti SCIENTIFIC QUALITY : 2 METHODOLOGY :2 NOVELTY : 3 MERIT : 1,5 FACILITY : 2) A halth Application for th managmnt of Alcohol Us Disordrs: A Randomizd Trial Lazio Clinicoassistnzial Brain Disordrs and Nuroscinc 10, Posizion Sub Ranking N 3 RF Clinico assistnzial con scor a 10,5 ((La Study Sssion ha assgnato la mdia com valor final prtanto gli scor mdi dll vari voci sono i sguntiscientific QUALITY : 2 METHODOLOGY: 2,25 NOVELTY : 2 MERIT : 2 FACILITY : 2,25) IMPROVING QUALITY AND CARE OPTIONS FOR THE END OF LIFE IN ADVANCED HEART FAILURE. Toscana Clinicoassistnzial Halthcar Dlivry and Mthodologis 10, Posizion Sub Ranking N 4 RF Clinico assistnzial con scor a 10,5 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY: 2,5 NOVELTY : 2 MERIT : 2,5 FACILITY : 1,5) Pagina 27 di 228

28 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Nuromlanin and iron dynamics in Parkinson s disas and othr synuclinopathis: invstigation of potntial nuroimaging markrs of nurodgnration and disas progrssion MONDINO Clinicoassistnzial Brain Disordrs and Nuroscinc 10, Posizion Sub Ranking N 5 RF Clinico assistnzial con scor a 10,5 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2 METHODOLOGY: 3 NOVELTY : 2 MERIT : 2 FACILITY : 1,5) Rfractory pilpsy or syncop incognito unmaskd by xhaustiv nurophysiologic and lctrocardiographic invstigations: a prospctiv, advancd diagnostic valuation that may allow an arly and altrnativ diagnosis in many patints with drug rsistant Calabria Clinicoassistnzial Brain Disordrs and Nuroscinc 10, Posizion Sub Ranking N 6 RF Clinico assistnzial con scor a 10,5 (La Study Sssion ha ffttuato un rscoring attribundo 4 alla Mthodology assgnado poi la mdia dll du valutazioni risultant dall'attribuzion dllo scor 4 a Mthodology. Prtanto gli scor finali validi sono i sgunti risultanti dal rscoring dlla Mthodology a 4 dalla mdia dll du valutazioni pr gli altri critri SCIENTIFIC QUALITY : 2 METHODOLOGY: 4 NOVELTY : 1,5 MERIT : 1,25 FACILITY : 1,75) Pagina 28 di 228

29 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Multicntr, opn, randomizd, prospctiv study for th valuation of safty and fficacy of normothrmic machin prfusion for organ prsrvation (Mtra ) in livr transplantation Toscana Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 10, Posizion Sub Ranking N 7 RF Clinico assistnzial con scor a 10,5 (La Study Sssion ha assgnato la mdia com valor final prtanto gli scor mdi dli critri sono i sgunti SCIENTIFIC QUALITY : 2,5 METHODOLOGY: 2,25 NOVELTY : 2 MERIT : 2,75 FACILITY : 1) Improving standards of car in Young Womn with Brast Cancr: a translational approach C.R.O. AVIANO Clinicoassistnzial Halthcar Dlivry and Mthodologis 10, Posizion Sub Ranking N 8 RF Clinico assistnzial con scor a 10,5 (Valutazion F2F compltata: SCIENTIFIC QUALITY : 2,5 METHODOLOGY: 2,5 NOVELTY : 1,5 MERIT : 2 FACILITY : 2) AUTOPHAGY IN PLASMA CELL ONTOGENESIS AND MALIGNANCY SAN RAFFAELE MILANO Biomdica Immunology 10, Cll intrinsic and xtrinsic mchanisms sustaining chmorfractorinss in Diffus Larg B Cll Lymphoma (DLBCL) and classical Hodgkin Lymphoma (chl): implications for diagnosis and thraputic targting HUMANITAS Biomdica Oncology 1 Basic Translational 10, ROLE OF THE DNAM 1/PVR PATHWAY IN THE PATHOGENESIS OF HIV 1 INFECTION OSPEDALE BAMBINO GESU' Clinicoassistnzial AIDS and Rlatd Rsarch Pagina 29 di 228

30 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not corrlats of crbral amyloid burdn in subjcts with nurodgnrativ cognitiv dclin SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc A multicntr study on th diagnosis, immun pathognsis and thrapy of chronic inflammatory dmylinating polyrardiculonuropathy (CIDP) and of its variants HUMANITAS Clinicoassistnzial Brain Disordrs and Nuroscinc Invstigating pigntic pattrns inducd by diffrnt dits and food for cancr prvntiv halth nhancmnt I.E.O. Biomdica Gns, Gnoms and Gntics Potntial rol of HDL Cholstrol Efflux Capacity in th valuation of cardiovascular risk in patints with Familial Hyprcholstrolmia (FH) IRCCS AOU San Martino IST (Gnova) Biomdica Cardiovascular and Rspiratory Scincs Immun rspons to human cytomgalovirus in th immunocomptnt and th immunocompromisd host: nw approachs and thir clinical impact SAN MATTEO Biomdica Infctious Disass and Microbiology Th transcription factor Prp1 as a novl molcular link for typ 2 diabts and adipocyt rlatd pathologis. Campania Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 30 di 228

31 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not ASSESSING A NOVEL RNA BASED THERAPEUTIC APPROACH FOR DOMINANT NEGATIVE MUTATIONS IN COLLAGEN TYPE VI RELATED MUSCULAR DYSTROPHIES: TARGETING SINGLE NUCLEOTIDE POLYMORPHISMS TO PROMOTE OUT OF FRAME EXON SKIPPING AND ALLELE SPECIFIC GENE SILENCING. Emilia Romagna Biomdica Gns, Gnoms and Gntics Prclinical dvlopmnt of anticoagulant compounds, slctiv inhibitors of thrombin and activatd Factor X, as potntial antitumor stratgis in pancratic cancr Lombardia Biomdica Oncology 1 Basic Translational Antidprssant activity of fingolimod in xprimntal animal modls and patints with multipl sclrosis NEUROMED Biomdica Brain Disordrs and Nuroscinc Survillanc of Multidrug Rsistant Organisms (MDROs) by a ntworkbasd stratgy: tracking molcular pidmiology and outcoms through th Nonatal Intnsiv Car Units Sicilia Clinicoassistnzial Infctious Disass and Microbiology Idntification of nuronal substrats of Phlan McDrmid syndrom to idntify thrapis in prclinical modls: corrlation btwn clinical outcom and molcular phnotyps of human nurons drivd from patint s hips clls CARLO BESTA Biomdica Brain Disordrs and Nuroscinc Pagina 31 di 228

32 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Mdium and long trm comparativ ffctivnss and costs analysis of TAVI vs AVR in patints with svr symptomatic aortic stnosis at mdiumlow risk Sicilia Clinicoassistnzial Halthcar Dlivry and Mthodologis Evaluation of nonatal fding on gut microbiota shaping: th nutritional valu of milks addd by bioactiv molculs OSPEDALE BAMBINO GESU' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Establishmnt of an Italian cohort study of psoriasis and psoriatic arthritis basd on rcord linkag of rgional halthcar administrativ databass, and assssmnt of th risk of svr infctions, major cardiovascular vnts, and cancr, in patints tr Lombardia Clinicoassistnzial Halthcar Dlivry and Mthodologis Add on short trm thrapy with pgylatd intrfron alfa in patints with HBAb positiv chronic hpatitis B who ar long trm rspondrs to nuclos(t)id tratmnt: dos it allow complt withdrawal of antiviral thrapy and dos it rduc th risk of liv Lazio Clinicoassistnzial Digstiv, Kidny and Urological Systms In vivo guidd rgnration of small diamtr artris (2 5 mm) using biodgradabl tubular scaffolds: rol of ndothlial prognitor clls in vasculognsis. Vnto Biomdica Bionginring Scincs and Tchnologis ATP P2X7R immunity promots Lombardia Biomdica Immunology brakdown of tolranc in typ 1 diabts Pagina 32 di 228

33 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not DEVELOPMENT AND IMPLEMENTATION OF NEW TOOLS FOR THE VERIFICATION AND CONTROL OF THE EFFECTIVENESS OF INTERVENTIONS IN PERSON WITH SPINAL CORD INJURY SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc "Stand and Walk". Optimizing th mbodimnt and agncy of rlvant robotic walkrs in spinal cord injury patints SANTA LUCIA Biomdica Bionginring Scincs and Tchnologis A multidisciplinary invstigation for th improvmnt of aortic ndografting: from biomdical nginring concpts to clinical implmntation SAN DONATO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Postural sway and facial mimicry as bhavioral markrs of covrt motor symptoms in Parkinson's disas in a nw diffrntial arly diagnostic protocol. SANTA LUCIA Biomdica Biobhavioral and Bhavioral Procsss Enhancmnt of mir 34a mdiatd nurognsis as novl thraputic approach for aging and nurodgnration Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc Analysis of th clinico pathological and prognostic valu of dfcts in transcriptional rgulation of ovarian cancr Lombardia Biomdica Oncology 1 Basic Translational Pagina 33 di 228

34 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Myo inositol in th prvntion of Sicilia gstational diabts in womn at high risk. A multicntric, randomizd, doublblind, placbo controlld study. Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Emrging halth&food safty/scurity risks from combind organic chmical, pharmacutical, and microbial hazards from civil wastwatr tratmnt plants sludgs rcycld as top soil improvrs in agricultur: "SAFE SOIL". Istituto Suprior di Sanita' Biomdica Vtrinary Idiopathic Parkinson Disas diagnosis and pathognsis: th sarch for rliabl biomarkrs Istituto Scinz Nurologich Clinicoassistnzial Brain Disordrs and Nuroscinc BONE, FATTY TISSUE AND CARDIOVASCULAR SYSTEM: STUDY OF INTERACTIONS AMONG THREE SYSTEMS IN OBESE CHILDREN Puglia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs and gntic prdisposition to gliomas and spinal tumors in nurofibromatosis typ 1. CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc Nw immunological markrs for improving th cur of inborn hamoglobinopathis by hmatopoitic stm cll transplantation Istituto Suprior di Sanita' Biomdica Vascular and Hmatology Pagina 34 di 228

35 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Safty, immunognicity and fficacy of vaccinations against Influnza, Pnumococcus, Hpatitis B, Papillomavirus and Hrps Zostr in patints with autoimmun disass undr immunosupprssiv tratmnt Lazio Clinicoassistnzial Immunology Tranxamic acid for hypracut primary IntraCrbral Hmorrhag Italy (TICH 2 Italy) Lombardia Clinicoassistnzial Brain Disordrs and Nuroscinc A longitudinal study on muscl synrgis during walking in sub acut strok prsons: rol of rcovry and rhabilitation DON GNOCCHI Biomdica Musculoskltal, Oral and Skin Scincs Gntic abnormalitis in C3 glomrulopathis and in immuncomplx associatd mmbranoprolifrativ glomrulonphritis MARIO NEGRI Biomdica Gns, Gnoms and Gntics 11, Charactrization of th molcular mchanisms allowing Nuroblastoma clls to supprss immun survillanc and st up of biothraputic approachs capabl to countract thir ffcts. GASLINI Biomdica Immunology 11, Rol of angiotnsin convrting nzyms inhibitors on cardioprotction against anticancr thrapy inducd cardiotoxicity: in vivo clinical vidncs along with in vitro studis I.E.O. Clinicoassistnzial 11, Pagina 35 di 228

36 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Molcular bass for prsonalizd ISTITUTO mdicin in psoriatic patints: analysis of DERMOPATICO xprssion and function of th PSORS1 DELL'IMMACOLATA locus gn CCHCR1 Biomdica Musculoskltal, Oral and Skin Scincs 11, Enginrd UC MSCs in multipl myloma tratmnt: a prclinical cytothrapy modl for both killing of tumor clls and haling ostolytic bon lsions. Puglia Biomdica 11, What maks a maltratd child bcom an adult drug abusr: uncovring nuroimaging/blood biomarkrs and dsigning rscu thraputic stratgis in prclinical modls SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 11, Transcriptional rgulatory ntworks in multipl sclrosis SAN RAFFAELE MILANO Biomdica Gns, Gnoms and Gntics 11, Macrophags and th dvlopmnt of fibrosis during nonalcoholic fatty livr disas: rol of intraction btwn iron mtabolism and hypoxia inducibl factor 2alpha Toscana Biomdica Digstiv, Kidny and Urological Systms 11, DEVELOPMENT AND VALIDATION OF A NOVEL LABORATORY IN VITRO ASSAY AIMED AT PREDICTING ALLERGIC OR TOLERANT RESPONSES TO CONTACT ALLERGENS SAN GALLICANO Biomdica Immunology 11, Pagina 36 di 228

37 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Failur of traditional risk factors in prdicting subclinical athrosclrosis. Sarch for novl imaging basd, biochmical and molcular markrs in a clinically halthy population. SAN MATTEO Biomdica Cardiovascular and Rspiratory Scincs 11, IS THERE A SYNERGYSM BETWEEN HEAD PAIN AND PELVIC PAIN IN WOMEN? THE CASE OF MIGRAINE AND ENDOMETRIOSIS A CLINICAL, NEUROPHYSIOLOGIC AND PHARMACOGENOMIC STUDY. SAN MATTEO Biomdica Brain Disordrs and Nuroscinc 11, Novl thraputic stratgis for Frontotmporal Lobar Dgnration by targting progranulin rlatd inflammatory pathways MARIO NEGRI Biomdica Brain Disordrs and Nuroscinc 11, Capturing human amniotic msnchymal stromal cll (hamsc) drivd ky ffctors that induc protction aftr traumatic brain injury MARIO NEGRI Biomdica Brain Disordrs and Nuroscinc 11, Combind targting of cancr clls and tumor supporting micronvironmnt by Natural Killr T lymphocyts nginrd with tumor spcific TCRs SAN RAFFAELE MILANO Biomdica Immunology 11, Pagina 37 di 228

38 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not GENOTYPE PHENOTYPE CORRELATION FOR MAGNETIC RESONANCE IMAGING FEATURES OF MOWAT WILSON SYNDROME WITH ZEB2 MUTATION/DELETION; A NEW INTERNATIONAL DATABASE AND FUTURE DISCOVERIES OF THE ROLE OF THE GENE ZEB2 IN THE DEVELOPMENT OF THE HUMAN BRAIN ARCISPEDALE Clinicoassistnzial Biobhavioral and Bhavioral Procsss 11, Istituto Suprior di Sanita' Biomdica EVALUATION OF THE THERAPEUTIC ACTIVITY OF UNIVERSAL, ANTI BETA GLUCAN ANTIBODIESAGAINST MAJOR HUMAN FUNGAL PATHOGENS Infctious Disass and Microbiology 11, Dvlompmnt of an innovativ 3D dynamic cultur modl in Bioractor to b usd as a surrogat Multipl Myloma micronvironmnt for th invstigation of tumor biology and th assssmnt of patint spcific rspons to drugs SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational 11, Th paradox of prsistnt 5 alpha rductas inhibition by finastrid: a modl of nuropathy and a pharmacogntic approach Emilia Romagna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 11, Food safty of bivalv molluscs: Dvlopmnt and application of molcular tools for idntification, quantification and valuation of antibiotic rsistanc and virulnc potntial of food associatd ntric and autochthonous bactrial pathogns IZSUM Biomdica Vtrinary 11, Pagina 38 di 228

39 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ultra high fild (UHF) sodium (23Na) MRI imaging as noninvasiv biomarkr for masuring structural changs and assssing prognosis of pathology in pdiatric brain tumors STELLA MARIS Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 11, Undrstanding th molcular bass of intllctual disability and autism spctrum disordrs associatd with macrocrania/macrosomia (IAMM). Istituto Suprior di Sanita' Biomdica Gns, Gnoms and Gntics 11, Intrplay btwn autophagy and S nitrosylation: implications in th gnsis, prolifration and rsistanc of glioblastoma stm clls SANTA LUCIA Biomdica Oncology 1 Basic Translational 11, Pr clinical dvlopmnt of radiolablld nanoparticls for molcular imaging of angiognsis Toscana Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 11, Myloid cll and adipocyt intraction in human bon marrow of frail ldrs: idntification of biomolcular markrs and thraputic targts of immun snscnc Vnto Biomdica Biology of Dvlopmnt and Aging 11, Pharmacological Targting of th nw GPR17 rcptor to prvnt advrs rmodling and hart failur in th ischmic hart MONZINO Biomdica Cardiovascular and Rspiratory Scincs 11, Pagina 39 di 228

40 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Comparing attndanc rat and advancd noplasia yild of colonoscopy and yarly FIT for post polypctomy survillanc of patints with intrmdiat and high risk adnomas Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis 11, A long trm valuation of th impact of a complx intrvntion to support Alzhimr's Disas patints and thir cargivrs. Th "Up Tch 2" projct I.N.R.C.A. Clinicoassistnzial Halthcar Dlivry and Mthodologis 11, Dfining th Combinatorial Supprssion of human Glioblastoma Cancr stm lik clls (hgscs) by th nurognic nich ffctors Ephrins and BMPs. Improving hgscs nrichmnt and sking nw hgsc spcific rgulators and novl thraputic options. CASA SOLLIEVO SOFFERENZA Biomdica Oncology 1 Basic Translational 11, An intgratd modl of multidisciplinary tools to targt th practic of prsonalizd mdicin in rhumatoid arthritis Emilia Romagna Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 11, Glycosaminoglycans as critical playrs in inflammation and tissu damag during chronic lung infction by Psudomonas aruginosa: prognostic and thraputic implications for cystic fibrosis SAN RAFFAELE MILANO Biomdica Infctious Disass and Microbiology 11, ERK5 and Hdghog pathways as novl targts for mlanoma tratmnt Toscana Biomdica 11, Pagina 40 di 228

41 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rduction into practic of a clinical grad stm cll markr basd signatur for th prognostic prdiction of brast cancr. I.E.O. Biomdica 11, Targting HMGB1 with BoxA in inflammation associatd cancr SAN RAFFAELE MILANO Biomdica 11, Epigntic marks and inflammatory profil of subcutanous adipos tissu in svrly obs subjcts bfor and aftr controlld caloric rstriction and xrcis training intrvntion. MAUGERI Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 11, Dlivring cognitiv stimulation through tlcommunication tchnology to prvnt dmntia S.CAMILLO Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs 11, Pathognsis and control of ostomylitis in priprosthtic infctions. Innat immun dfns against biofilm and dsign of antiinfctiv biomatrials RIZZOLI Biomdica Infctious Disass and Microbiology 11, Molcular mchanisms and thraputic implications of alpha 7 nachr antiinflammatory pathways in th prvntion of obsity linkd comorbiditis AUXOLOGICO Biomdica Cll Biology 11, PINOCCHIO: computd aidd Planning and monitoring biological bon rconstructions in CHIldrn Oncology. RIZZOLI Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 11, Pagina 41 di 228

42 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Targting strss rspons pathways in human mlanoma ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 11, T cll rspons to anti TNF alpha thraputical agnts in tratd patints to prvnt loss of rspons and advrs drug ractions Toscana Biomdica Immunology 11, Evaluation of biological proprtis and in vivo prsistnc of human mmorylik Natural Killr clls as a tool for a novl approach of antitumor cll thrapy in pdiatric patints with high risk solid tumors givn ithr autologous or allognic hmat SAN MATTEO Clinicoassistnzial Immunology 11, Slctiv uprgulation of KIR rcptors by hrpsvirus infction: a novl pathogntic mchanism in multipl Sclrosis SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc 11, Toward idntification of biomarkrs in patints with irritabl bowl syndrom (IBS) Emilia Romagna Clinicoassistnzial Digstiv, Kidny and Urological Systms 11, Intstinal microbiom biomarkrs for non cliac glutn snsitivity: nw diagnostic and thraputic targts. Emilia Romagna Biomdica Gns, Gnoms and Gntics 11, Primat to human cross spcis transmission of simian Typ D rtrovirus (SRV): sroprvalnc study in Italian cohorts. Istituto Suprior di Sanita' Clinicoassistnzial Infctious Disass and Microbiology 11, Pagina 42 di 228

43 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Inhibition of JNK PSD95 intraction: a novl stratgy to prvnt Alzhimr's disas MARIO NEGRI Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 11, Idntification of biological faturs accounting for priphral T cll lymphomas pathognsis and rfractorinss to Romidpsin in association with anthracyclin basd combination chmothrapy ISTITUTO TUMORI MILANO Clinicoassistnzial 11, Targting Endothlin 1/YAP signaling to circumvnt chmorsistanc in ovarian cancr REGINA ELENA Biomdica 11, Effcts on brain xcitability of antibodis drivd from pilptognic autoimmun ncphalitis CARLO BESTA Biomdica Brain Disordrs and Nuroscinc 11, bdsid to bnch invstigation of th cardiac advrs ffcts of protasom inhibition: obsrvational study in multipl myloma patints, and molcular invstigation in xprimntal modls of protasom failur dpndnt cardiomyopathy. Vnto Biomdica Cardiovascular and Rspiratory Scincs 11, Th impact of a modrat CAlori and protin REstriction PROgram (CARE PRO) as an fficint and affordabl thrapy in patints with Barrtt's Esophagus. I. O. V. Clinicoassistnzial Risk, Prvntion and Halth Bhavior 11, Pagina 43 di 228

44 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Phas II trial of carfilzomib and lnalidomid basd tratmnt for transplant ligibl and non ligibl nwly diagnosd patints with primary plasma cll lukmia: a total thrapy modl with focus on prognostic rol of gnomic signatur. CROB Biomdica 11, Targt idntification and rlvanc assssmnt of rgistrd drugs with mylin rpair potntial Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 11, Effcts of diffrnt nutritional supports on muscular and mtabolic outcoms in sarcopnic and pr sarcopnic patints with typ 2 diabts mllitus as add on to nuromuscular training pr Total Joint Rplacmnt Pimont Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 11, Dvlopmnt and Evaluation of Influnza Virus Polymras Inhibitors for Combination Antiviral Thrapy Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 11, Advancd thrapis in Parkinson s disas. and nurophysiological ffcts of continuous duodnal/jjunal lvodopa/carbidopa pump infusion and dp brain stimulation of th subthalamic nuclus (STN) NEUROMED Clinicoassistnzial Brain Disordrs and Nuroscinc 11, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Brain mitochondrial dysfunction, abnormal thrmodynamics and inflammation in Parkinson's disas: invstigation of thr intrrlatd putativ causs MAGGIORE Biomdica Brain Disordrs and Nuroscinc Pagina 44 di 228

45 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not STUDIES ON THE POTENTIAL USE OF EXTRACELLULAR VESICLES IN THE THERANOSTICS (THERAPY AND DIAGNOSIS, WHOLE IN ONE) OF CANCER Istituto Suprior di Sanita' Biomdica Rgulation and rol of CCAR2 in DNA damag rspons and brast cancr progrssion ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro suprior a Charactrisation of basal and postabsorptiv Glucagon Lik Pptids scrtory profil in patints with Mtabolic Syndrom and Inflammatory Bowl Disas SAN MATTEO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Futur scnario in HCV infction thrapis: idntification of viral dtrminants of tratmnt outcom succss Lombardia Clinicoassistnzial Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Analysis of plasma and urinary xtracllular vsicls in kidny transplant rcipints for th dtction and monitoring of immunologic and infctious complications Pimont Biomdica Digstiv, Kidny and Urological Systms Pagina 45 di 228

46 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt Of A Novl Adoptiv Cll Transfr Approach (ACT) For Cancr Immunothrapy Basd On Th Us Of Autologous IFN DC For Th Induction Of Anti Tumor Rspons And Implmntd By Stratgis Aimd At Extnding Th Rplicativ Lifspan Of Th Anti Tumo Istituto Suprior di Sanita' Biomdica Dtcting "brain at risk" for Vascular Dmntia: th rol of potntial prclinical markrs from Transcranial Magntic Stimulation Sicilia Biomdica Brain Disordrs and Nuroscinc Novl biomarkrs of rcurrnc and druggabl pathways to prvnt tumor rlaps inarly stag non small cll lung cancr (NSCLC) patints Umbria Clinicoassistnzial Oncology 1 Basic Translational A natural Aß variant with dominant ngativ ffct on amyloidognsis nginrd to tackl Alzhimr's disas CARLO BESTA Biomdica Brain Disordrs and Nuroscinc Impact of Diabts on th Rgnrativ Potntial of th Human Rnal Glomrulus. SAN RAFFAELE MILANO Clinicoassistnzial Biology of Dvlopmnt and Aging Fractal Lacunarity of Trabcular Bon in Magntic Rsonanc Imags of Lumbar Vrtbras: Validation of a Nw Diagnostic Tool for Ostoporosis and Fractur Risk I.N.R.C.A. Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Pagina 46 di 228

47 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Inducd Pluripotnt Stm Clls from schizophrnic patints as platforms for disas modling and for undrstanding th molcular and cllular basis of rfractorinss to clozapin tratmnts. Lombardia Biomdica Brain Disordrs and Nuroscinc Nanoformulatd antirtroviral drug for HIV radication from sanctuary sits Lombardia Biomdica AIDS and Rlatd Rsarch Us of Fluorin 18 fluorodoxyglucos (18F FDG) positron mission tomography (PET) scan in guiding tratmnt and dtrmining prognosis in pulmonary sarcoidosis SAN RAFFAELE MILANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Multi pitop ERBB2 targting with humanizd antibodis REGINA ELENA Biomdica Bionginring Scincs and Tchnologis Targtd gnom diting in Rcombination activating gn (RAG) 1: prcis corrction of th gntic dfct in human SCID. HUMANITAS Biomdica Immunology Th purinrgic P2X7 rcptor on human cardiac fibroblast: a nw thraputic targt for advrs cardiac rmodlling in chronic hart failur? Toscana Biomdica Cardiovascular and Rspiratory Scincs A multidisciplinary approach that combins volutionary analysis, protin modlling, clinical and pidmiological gntics to clarify th pathognic mchanisms undrlying viral/bactrial ncphalitis. MEDEA Biomdica Gns, Gnoms and Gntics Pagina 47 di 228

48 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Tratmnt of joint dgnration: a nw stratgy for a nw tiopathology targt. A comparativ study on cll fr scaffold vs bon marrow concntrat for subchondral bon lsions. RIZZOLI Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Padiatric Bipolar Disordr with comorbid Attntion Dficit / Hypractivity: nw priphral putativ biomarkrs and prclinical assssmnt of pharmaco thrapy. Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc Silk protin platform for fficint mimicking of th bon marrow vascular nich and functional platlt production: a translational rsarch stratgy to undrstand platlt rlatd disass and prdict fficacy for candidat thraputics SAN MATTEO Biomdica Bionginring Scincs and Tchnologis Oluropin aglycon fficacy against Alzhimr's disas: an advancd biological prclinical invstigation and a proof of concpt study in mild Alzhimr's disas patints Toscana Biomdica Brain Disordrs and Nuroscinc Analysis of th rol of oxystrols/lxrs in tumorignsis SAN RAFFAELE MILANO Biomdica Immunology Prokinticin 2 in autoimmun dmylinating disas of th cntral nrvous systm: a possibl novl targt for immun intrvntion CARLO BESTA Biomdica Immunology Pagina 48 di 228

49 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Quality of lif in spinal cord injury: mthods of masurmnts and corrlation with individual paramtrs MAUGERI Clinicoassistnzial Halthcar Dlivry and Mthodologis Intnsification with dolutgravir in patints who hav a stably supprssd HIV 1 virmia during boostd ritonavir protas inhibitor monothrapy (Dolutgravir Protas Inhibitor Monothrapy Intnsification DOLPHIN Study) SPALLANZANI Clinicoassistnzial AIDS and Rlatd Rsarch Protin aggrgation and dysrgulation of RNA mtabolism in FET modl of ALS SANTA LUCIA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Rol of gn mthylation in th risk of ischmic strok NEUROMED Biomdica Gns, Gnoms and Gntics Disscting WT1 mutations in lukmia I. O. V. Biomdica Oncology 1 Basic Translational Th us of classical conditioning with a tlmdicin approach for anomia rhabilitation in chronic aphasia: a clinical outcom rsarch SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Cll fr DNA mthylatd squncs in coronary artry disas: rol as nw potntial pathophysiologic markrs SAN DONATO Biomdica Gns, Gnoms and Gntics Dvlopmnt of anti giardial drugs targting g intractions. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Pagina 49 di 228

50 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not APPLICATIONS OF X RAY FLUORESCENCE BASED TECHNIQUES AND ADVANCED IMAGING METHODS TO UNRAVEL CHANGES IN IRON METABOLISM AND METAL TOXICITY IN CHILDREN BURLO GAROFALO Biomdica Biological Chmistry and Macromolcular Biophysics THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS). MONDINO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc How a multi organ (Hart, Thyroid, Kidnys) multi markr stratgy may improv risk prdiction in childrn undrgoing cardiac surgry: a modl to prov that biomarkrs in pdiatric cardiac surgry ar not mystrious but usful tools. Toscana Clinicoassistnzial Cardiovascular and Rspiratory Scincs Th alpha Mlanocyt Stimulating Hormon/ Proxisom Prolifrator Activatd Rcptor gamma connction: nw insights on mlanoma risk assssmnt SAN GALLICANO Biomdica Cll Biology Impact and ffctivnss of clinical pharmacyst's intrvntions in th multidisciplinary car of HIV infctd patints with comorbiditis including cancr, tratd with polypharmacy. A randomizd controlld clinical trial to assss halth outcoms by adop C.R.O. AVIANO Clinicoassistnzial Halthcar Dlivry and Mthodologis Pagina 50 di 228

51 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Intnsity modulatd clinical stting Hospitals: impact on Halth Population Outcoms Agnzia pr i Srvizi Sanitari Rgionali Clinicoassistnzial Halthcar Dlivry and Mthodologis Gastrointstinal Tract Prmability and Inflammation in HIV Infctd patints with mild to modrat Chronic Kidny Disas: a cross ovr, doubl blind, randomizd clinical trial Emilia Romagna Biomdica AIDS and Rlatd Rsarch Establishing a platform for th translatomic analysis of ALS/FTD pathognsis and disas progrssion in transgnic modls SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc Nurogn origin of hyprtnsion in Lazio hmodialytic patint: morphomtric study of rnal sympathtic innrvation, its pathogntic rol and fficacy of rnal bilatral dnrvation. Clinicoassistnzial Cardiovascular and Rspiratory Scincs Epigntics in nurodgnrativ dmntias: circulating clls and drivd pluripotnt stm clls (ipscs) from patints to idntify pathognic mchanisms and potntial biomarkrs SANTA LUCIA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Novl 2D and 3D human modls of cardiornal pathophysiology and drug discovry Vnto Biomdica Bionginring Scincs and Tchnologis Pagina 51 di 228

52 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Disscting th rol of th B cll rcptorrgulatd mir 132/212 clustr in mdiating anrgy and apoptosis in normal and malignant B clls C.R.O. AVIANO Biomdica Oncology 1 Basic Translational Estrogn dpndnt M1/M2 macrophag balanc as a novl cardiovascular risk biomarkr in rlation to hormonal status and pathological amnorrha in frtil womn Vnto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Intrplay btwn Myloid Drivd Supprssor Clls and Hmatopoitic Prognitor Clls: rol in th rgulation of immun rspons and immun rconstitution procss during HIV infction. SPALLANZANI Biomdica AIDS and Rlatd Rsarch Mtabolic rprogramming as thraputic stratgy to amliorat skltal muscl tissu nginring procdurs. SAN RAFFAELE PISANA Biomdica Musculoskltal, Oral and Skin Scincs Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro suprior a EMrging MEditrranan BIOtoxins in fish and shllfish products: mthods for th idntification of algal toxins and study on th mchanism of action, trophic transfr and potntial risk for th human halth (EMMEBIO) IZSUM Biomdica Vtrinary Hxabromocyclodcans (HBCDDs) and Novl Brominatd Flam Rtardants (NBFRs): food lvls, nvironmntal contamination and toxicological ffcts. IZSUM Biomdica Vtrinary 12, Pagina 52 di 228

53 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idiopathic Inflammatory Myopathis: idntification of a diagnostic pigntic biomarkr MYOMIRNA Emilia Romagna Biomdica Musculoskltal, Oral and Skin Scincs 12, Association btwn long trm xposur to air pollution and nurological and mtabolic impairmnt in adults of two larg Italian longitudinal studis Pimont Clinicoassistnzial Population Scincs and Epidmiology 12, Targting pigntic rgulation of proangiognic factors in malignant gliomas Vnto Biomdica Brain Disordrs and Nuroscinc 12, Novl pathways to chmorsistanc in chronic lymphocytic lukmia: study of Toll lik rcptors signaling molculs. SAN RAFFAELE MILANO Biomdica Immunology 12, Unravlling th impact of diffrnt tratmnt stratgis on intra clonal htrognity in Multipl Myloma Emilia Romagna Biomdica Gns, Gnoms and Gntics 12, Impact of asbstos mdiatd inflammation in msothlioma gnsis and progrssion. Implication for arly diagnosis, prognosis and thrapy HUMANITAS Biomdica Oncology 1 Basic Translational 12, A rtrospctiv pidmiological valuation of Multipl Sclrosis in Umbria Umbria Clinicoassistnzial Brain Disordrs and Nuroscinc 12, Pagina 53 di 228

54 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Assssmnt of th risk for consumrs xposd to industrial, urban and agricultural nvironmntal contaminants driving from th illgal disposal of wasts within th Land of Fir (Campania Rgion) Istituto Suprior di Sanita' Biomdica Vtrinary 12, Rol of 'non classical' rnin angiotnsinsystm in th progrssion of diabtic nphropathy in a rat modl of typ 1 diabts. SAN MATTEO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 12, Instrumntal Larning of Antrior Insular Cortx Activity with Ral tim fmri in AutismSpctrum Disordrs. S.CAMILLO Biomdica Brain Disordrs and Nuroscinc 12, Innovativ anti angiogntic compounds for human disass MULTIMEDICA Biomdica Vascular and Hmatology 12, Epigntics Mts Mtabolomics: A Novl Diagnostic and Thraputic Approach in Hart Failur Campania Biomdica Cardiovascular and Rspiratory Scincs 12, Idntification and valuation of noncliac glutn snsitivity by morphologic and functional magntic rsonanc imaging using dynamic contrast nhancd and diffusion wightd imaging mthods in comparison with a basic immunological study Lazio Biomdica Immunology 12, Pagina 54 di 228

55 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not semg dscriptors of fatigu as outcom masurs in facioscapulohumral dystrophy: analysis of th ffcts of branchd chain amino acid supplmntation MAGGIORE Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 12, Evnt basd modlling of Alzhimr's disas progrssion to assist clinicians in th arly diagnosis and prognosis on a singl patint scal SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc 12, Rol of glycosylation in Alzhimr's disas MARIO NEGRI Biomdica Brain Disordrs and Nuroscinc 12, Towards saf, ffctiv and fasibl adoptiv T cll thrapy of solid tumors SAN RAFFAELE MILANO Biomdica 12, Nw biomarkr for thrombotic strok in young patints: diagnostic and pathognic rol of anti phopsholipid antibodis (apl) spcific for bta2 glycoprotin I (B2GPI) Domain I AUXOLOGICO Biomdica Immunology 12, Nxt gnration squncing to uncovr novl markrs and thraputic targts for radioiodin rsistant papillary thyroid carcinoma ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 12, Pliotropic ffcts of proprotin convrtas subtilisin kxin typ 9 (PCSK9) targting: focus on xtra hpatic tissus. MULTIMEDICA Biomdica Cardiovascular and Rspiratory Scincs 12, Pagina 55 di 228

56 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Elvatd lvls of HbA1c in subjcts with normal glucos tolranc ar associatd with cardiovascular risk profil: rol of solubl Rcptor for Advancd Glycation End products (srage). Sicilia Biomdica Risk, Prvntion and Halth Bhavior 12, , gntics and pidmiological assssmnt of familial and sporadic frontotmporal dmntias in a population basd study with th validation of a clinical basd cohort. CASA SOLLIEVO SOFFERENZA Biomdica Brain Disordrs and Nuroscinc 12, Nw analytical stratgis to improv food safty: dvlopmnt of fast and high snsitiv mthods, basd on powrful and innovativ matrials, to dtct pathognic bactria and thir toxins IZSME Biomdica Vtrinary 12, Modulation of SHP2's allostric rgulation as a novl stratgy to trat hmatologic malignancis and RASopathis Istituto Suprior di Sanita' Biomdica 12, A comparativ study of polydoxyribonuclotid (PDRN) with hyprbaric oxygn (HBO) thrapy on th haling of chronic diabtic foot ulcrs. (THE POLYHBODFU study) Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 12, Pagina 56 di 228

57 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Daily monitoring of pdiatric asthmatic outpatints: pollution and halth rlationship. Studis of th adoption and dissmination of halth risk bhavior prvntiv intrvntions and srvics or adhrnc to tratmnt and/or complmntary tratmnts OSPEDALE BAMBINO GESU' Clinicoassistnzial Risk, Prvntion and Halth Bhavior 12, Dpicting common molcular OSPEDALE BAMBINO mchanisms of livr and hart damag in GESU' ordr to improv diagnostic and thraputic managmnt of hpatocardio mtabolic syndrom in childrn Biomdica Digstiv, Kidny and Urological Systms 12, MECHANISMS GOVERNING THE PERITONEAL DISSEMINATION AND THE CHEMORESISTANCE OF THE EPITHELIAL OVARIAN CANCER ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 12, Sxual orintation as a social dtrminant of halth: non gntic prdictors, quality of lif, halth status, and burdn of slctd mntal and nonmntal halth disordrs among young adults in Friuli Vnzia Giulia. Friuli Vnzia Giulia Clinicoassistnzial Population Scincs and Epidmiology 12, mtor inhibition and cardiovascular aging in chronic kidny disas Puglia Biomdica Cardiovascular and Rspiratory Scincs 12, Impact of prnatal xposur to nw anti HCV agnts on matrnal and nonatal outcoms. Istituto Suprior di Sanita' Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 12, Pagina 57 di 228

58 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Cardiac rmodlling in obs patints aftr diffrnt bariatric procdurs: novl tools in Cardiac Magntic Rsonanc and andslction of a novl clustr of cardio mtabolic biomarkrs. Lazio Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 12, CARDIOGEN DECODER: Intrprtation of clinical, pathologic, imaging and gntic big data in a larg population of gnotypd hritabl cardiomyopathis. SAN MATTEO Biomdica Cardiovascular and Rspiratory Scincs 12, Dvlopmnt and charactrization of non invasiv and clinically rlvant mous modls of drug rsistant lukmia: cllular, molcular, and functional studis dirctd to th idntification of thraputic targts for chmothrapy rsistant human lukmia c IZSLER Biomdica Oncology 1 Basic Translational 12, Activ survillanc or radical tratmnt in patints with nwly diagnosd low risk prostat cancr: a population basd comparativ ffctivnss study in th Oncological Ntwork of Pidmont and Vall d'aosta Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis 12, Analysis of dfcts in th dvlopmnt of intrnurons causd by dysrgulation of Rac signaling rlvant to nuropsychiatric disordrs. SAN RAFFAELE MILANO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 12, Novl multi analyt point of car tsting dvic for rapid diagnosis and managmnt of spsisand svr infction. Toscana Biomdica Intrdisciplinary Molcular Scincs and Training 12, Pagina 58 di 228

59 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Anti biopharmacutical immunization: valuation of immunognicity of biological agnts in immunomdiatd disass through th dtction of antidrug antibodis, analysis of its clinical rlvanc and risk factors Toscana Biomdica Immunology 12, Functional dissction of th bon marrow privilgd maturation nich of Plasmodium falciparum transmission stags in a humanizd mous modl Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 12, Atrial Tissu Charactristics and Mtabolic Dysrgulation in Post Oprativ Atrial Fibrillation. A Substudy of th OPERA Intrnational Trial Emilia Romagna Biomdica Cardiovascular and Rspiratory Scincs 12, Rol of GluD1 in Rtt syndrom: studis in a murin modl and human ips clls MARIO NEGRI Biomdica Gns, Gnoms and Gntics 12, Prospctiv Appraisal of Th Prvalnc of Primary Aldostronism in HYprtnsiv Patints Prsnting with Lon Atrial Fibrillation (PAPPHY Study): Undrstanding Th Mchanisms To Optimiz Th Diagnosis. Vnto Clinicoassistnzial Cardiovascular and Rspiratory Scincs 12, EMERGING ONCOGENIC PAPILLOMAVIRUS AND POLYOMAVIRUS IN WATER ENVIRONMENTS: A COMPREHENSIVE APPROACH TO ASSESS THE POTENTIAL FOR WATERBORNE TRANSMISSION Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 12, Pagina 59 di 228

60 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Fosl2 as a p53 antagonist in cancr dvlopmnt and progrssion C.R.O. AVIANO Biomdica Oncology 1 Basic Translational 12, Cardiovascular risk and gntic hyprcholstrolmias: improving risk assssmnt to optimiz tratmnt Sicilia Biomdica Gns, Gnoms and Gntics 12, Intractions btwn Epstin Barr virus and human cytomgalovirus infctions and systmic lupus rythmatosus: an intgratd virological, immunological and clinical analysis SAN MATTEO Biomdica Immunology 12, Th functional basis of crbrocrbllar connctivity: implications for dysfunction in Alzhimr disass MONDINO Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 12, Evaluation of bis maltolats, a novl class of maltol drivd compounds, as novl thraputic tool for th tratmnt of high risk mylodysplastic syndrom (MDS) as singl agnts or in combination with DNA dmthylating drugs. March Biomdica 12, Linking mtagnomic and mtabolomics profiling of th human intstinal microbiota to gut immun altrations in autoimmun Typ 1 Diabts SAN RAFFAELE MILANO Biomdica Immunology 12, Molcular targting of Notch signaling as a novl thraputic stratgy for multipl myloma tratmnt MAGGIORE Biomdica Oncology 1 Basic Translational 12, Pagina 60 di 228

61 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not OLEUROPEIN FOR TREATMENT OF ULCERATIVE COLITIS: FROM BENCH SIDE TO CLINICS. Calabria Biomdica Digstiv, Kidny and Urological Systms 12, Anti inflammatory ffcts of vagal activation in patints with ST lvation myocardial infarction tratd with primary prcutanus coronary intrvntion SAN MATTEO Biomdica Cardiovascular and Rspiratory Scincs 12, Epigntics in dystrophic pidrmolysis bullosa: towards novl thrapis to countract drmal fibrosis and carcinoma dvlopmnt ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Musculoskltal, Oral and Skin Scincs 12, Dvlopmnt of innovativ in vitro infction modls, basd on human cll rprogramming and gn diting, to invstigat th biology and pathognsis of nurotropic viruss and to tst nw antiviral molculs. Vnto Biomdica Infctious Disass and Microbiology 12, A multidisciplinary study for th discovry of nw clinical, mtabolomic and protomic markrs for th prdiction and dtction of gstational diabts Vnto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Evaluation of th immun rspons against Mycobactrium avium subsp. paratubrculosis (MAP) in humans and animals IZSUM Biomdica Immunology Pagina 61 di 228

62 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not dl oncolytic virus and innat immun rspons stimulation in Anaplastic Thyroid Carcinoma modls Campania Biomdica Th Hrditary Diffus Gastric Cancr syndrom: from suscptibility gns to clinical managmnt I.E.O. Biomdica Gns, Gnoms and Gntics Dndritic cll basd vaccin thrapy in msothlioma patints: prclinical and phas I clinical studis Istituto Suprior di Sanita' Biomdica Molcular dissction of th cross talk btwn cll plasticity and autophagy in brast cancr C.R.O. AVIANO Biomdica Oncology 1 Basic Translational Risk assssmnt from tattoos and lasr tattoo rmoval: valuation of drmal toxicity, cll toxicity and gn toxicity of nano and micro substancs SAN GALLICANO Biomdica Risk, Prvntion and Halth Bhavior Hony bs as a sntinl spcis for PAHs nvironmntal contamination IZSVE Biomdica Vtrinary Inducd pluripotnt stm clls (ips) as a nw modl for cardiac and skltal muscl pathognsis in myotonic dystrophy typ 1 (DM1). DON GNOCCHI Biomdica Gns, Gnoms and Gntics NK, hrpsvirus infction and HLA G molculs as prognostic markrs for primary unxplaind infrtility. Emilia Romagna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 62 di 228

63 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Changs in functional topography of th motor output aftr spinal cord injury SANTA LUCIA Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Thr Month Wkly Rifapntin/Isoniazid Vrsus 6 Month Slf administrd Daily Isoniazid with or without SMS Rmindrs for th Tratmnt of Latnt Tubrculosis Infction among Immigrants in Italy: a Randomizd Trial Lombardia Clinicoassistnzial Infctious Disass and Microbiology Ciliognisis and sonic hdghog signaling in Nimann Pick typ C disas: possibl rol in disas pathognsis. Friuli Vnzia Giulia Biomdica Brain Disordrs and Nuroscinc Th ffct of physiologically rprsntativ complx contxt on Total Kn Rplacmnt war. Toward th intrprtation and th knowldg of tribological procsss in joint prosthss. RIZZOLI Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Immunomdiatd mchanisms of disas progrssion in multipl myloma Puglia Clinicoassistnzial Oncology 1 Basic Translational Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Pagina 63 di 228

64 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not IDENTIFICATION OF GENETIC VARIANTS UNDERLYING BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS USING EXOME SEQUENCING AND CORRELATION TO THE CLINICAL PHENOTYPE SAN RAFFAELE MILANO Biomdica Cardiovascular and Rspiratory Scincs Evaluation of human xposur to Ads mosquitos: intgration of molcular and immunological approachs for th dvlopmnt of novl tools to assss vctor control stratgis and stimat arboviral disas risk. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Autoractiv mmory stm T clls gnration and xpansion post islt transplantation SAN RAFFAELE MILANO Biomdica Immunology Govrnanc for th smart managmnt of popl with cognitiv disordrs and dmntia Calabria Clinicoassistnzial Brain Disordrs and Nuroscinc Optimization of adoptiv immunothrapy protocols for EBVdrivn tumors xprssing a rstrictd pattrn of subdominant viral antigns C.R.O. AVIANO Biomdica charactrization and analytical confirmation of acut intoxications rlatd to nw psychoactiv substancs (NPS) of abus idntifid through th spcialist activity of a Poison Control Cntr: dfining a nw mrging public halth issu. MAUGERI Clinicoassistnzial Risk, Prvntion and Halth Bhavior Pagina 64 di 228

65 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Viral prsistnc, chronic immun activation, and drug pntration in th Cntral Nrvous Systm of HIV infctd subjcts: prdictors of viral compartmntalization in crbrospinal fluid and clinical outcoms (CENES Study). SPALLANZANI Clinicoassistnzial AIDS and Rlatd Rsarch MiRNA xprssion profil in Amyotrophic Latral Sclrosis and intraction with biomarkrs of clinical faturs Puglia Biomdica Brain Disordrs and Nuroscinc Biological profil of monocyt drivd macrophags and its corrlation with plaqu morphology in ischmic hart disas MONZINO Clinicoassistnzial Cardiovascular and Rspiratory Scincs and gntic charactrization of a rlvant cohort of Myasthnia gravis patints to prdict clinical pathways and dvlopmnt of tlconsultant activitis for rmot monitoring of th patint. Toscana Clinicoassistnzial Halthcar Dlivry and Mthodologis HAART and prgnancy: cllular/tissu impact analysis in prgnant womn and utro xposd nwborn, and idntification of nw strss rlatd biomarkr SPALLANZANI Biomdica AIDS and Rlatd Rsarch Pagina 65 di 228

66 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Functional and molcular charactrization of th pigntic ntwork that controls gn xprssion during nurognic muscl atrophy: nw potntial targts for thrapis against muscl wasting causd by nurognic disordrs and aging. SANTA LUCIA Biomdica Musculoskltal, Oral and Skin Scincs Bactricidal/prmability incrasing foldcontaining family B mmbr 4 NEUROMED Biomdica Cardiovascular and as a nw thraputic targt to fight cardiovascular disass Rspiratory Scincs Dciphring th rol of th mtor pathway in th rgulation of ASCL1 inducd invasivnss of glioblastoma cancr stm clls SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational Mmbran composition and dynamics in Plasmodium infctd rythrocyts: nw approachs for malaria control Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Rol of lipid signaling in Alzhimr s disas: idntification and modulation of survival molcular pathways to countract nurodgnration. SAN RAFFAELE PISANA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Evaluation of th vctor comptnc of mosquito spcis within th Culicina sub family for both circulating and importabl arboviruss, and assssmnt of th potntial xposur of animal and human populations to infctd vctors in North Eastrn Italy. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Pagina 66 di 228

67 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Strngthning th italian participation to indpndnt, nonprofit randomizd clinical trials in Europ by supporting and implmnting ItaCRIN, th italian hub of ECRIN consortium. Istituto Suprior di Sanita' Clinicoassistnzial Halthcar Dlivry and Mthodologis REWIND Rcovry of Equilibrium during Walking IN patints with strokrlatd Disass SANTA LUCIA Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Prclinical and phas II clinical study of cisplatin, ctuximab and valproic acid in rcurrnt and/or mtastatic squamous cll carcinoma of th had and nck PASCALE Clinicoassistnzial Abnormal phosphatidylcholin mtabolism as a bas for tailord molcular imaging and for thrapy targting in human tripl ngativ brast cancr Istituto Suprior di Sanita' Biomdica Influnc of mtallostrogns on risk of dvloping diffrnt brast cancr subtyps: an Italian cohort study ISTITUTO TUMORI MILANO Clinicoassistnzial Population Scincs and Epidmiology Phas 1 2 study of valproic acid combind with radiothrapy and chmothrapy in locally advancd nonsmall cll lung cancr (V LANCE study) PASCALE Clinicoassistnzial Muscular vibration asociatd with transcranial magntic stimulation may rliv spasticity in patints with multipl sclrosis NEUROLESI Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 67 di 228

68 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not PATHOGENIC CHARACTERIZATION OF AUTOSOMAL RECESSIVE SPASTIC ATAXIA OF CHARLEVOIX SAGUENAY TRHOUGH STUDIES IN VITRO AND IN VIVO STELLA MARIS Biomdica Brain Disordrs and Nuroscinc Gut Bactria (microbiota) in HpAtic EncphaLopathy and Possibl Utility of its Modulation (th GOAL study) DE BELLIS Clinicoassistnzial Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Action obsrvation tratmnt to improv cortical plasticity and uppr limb functions in chronic strok patints: a RCT study from basic nuroscinc to traditional and hom basd clinical rhabilitation. SAN RAFFAELE PISANA Clinicoassistnzial Biobhavioral and Bhavioral Procsss A nw diagnostic tool basd on Raman spctroscopy for fast, asy and chap dtrmination of plasmatic concntrations of antipilptic drugs CARLO BESTA Clinicoassistnzial Bionginring Scincs and Tchnologis Prdiction of livr adnoma and carcinoma onst by assssmnt of mirna in th blood GASLINI Biomdica Gns, Gnoms and Gntics Gn xprssion profil of priphral nrvs in patints with Amyotrophic Latral Sclrosis. SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc Pagina 68 di 228

69 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Mlanoma progrssion: idntification of nw pigntic, druggabl candidats of tumor growth in vivo. I.E.O. Biomdica Oncology 1 Basic Translational Th mrging rol of micrornas in autism spctrum disordrs Associazion Oasi Maria SS Biomdica Gns, Gnoms and Gntics Potntial impact of a traditional Mditrranan Dit on strogn, inflammation and cholstrol homostasis: a Brmuda triangl for CVD risk? Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs A randomizd clinical trial to valuat th fficacy of Horticultural Thrapy Protocol (HTP) on bhavioral disordrs in popl with mild to modrat Alzhimr s disas. Istituto Suprior di Sanita' Clinicoassistnzial Brain Disordrs and Nuroscinc Study of molcular mchanisms undrlying Altrnating Hmiplgia of childhood by a novl in vitro modl of human nuronal clls xprssing ATP1A3 gn mutations Lazio Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 13, Chss producd from raw milk: ffct of hat tratd milk on safty, charactristic organolptic and nutritional proprtis IZSLER Biomdica Vtrinary 13, Dynamic tracing of th impact of nutralising and inhibitory nonnutralising antibodis on HIV 1 infction of dndritic clls and macrophags at mucosal sits. SAN RAFFAELE MILANO Biomdica AIDS and Rlatd Rsarch 13, Pagina 69 di 228

70 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ingstibl capsul for photodynamic tratmnt of Hlicobactr pylori infction Toscana Biomdica Infctious Disass and Microbiology 13, Th rol of multiparamtric Magntic Rsonanc Imaging in th slction of patints with nwly diagnosd prostat cancr at vry low risk suitabl for activ survillanc: a prospctiv multiinstitutional study Emilia Romagna Clinicoassistnzial Digstiv, Kidny and Urological Systms 13, PHARMACOLOGICAL ACTIVATORS OF TMEM16A AND SLC26A9 CHLORIDE CHANNELS TO POTENTIATE MUCOCILIARY CLEARANCE AND INNATE DEFENSE MECHANISMS IN HUMAN AIRWAY DISEASES GASLINI Biomdica Cll Biology 13, Th molcular basis of th intrplay btwn lukotrin and purinrgic systms: nw thrapis in vascular inflammation Lombardia Biomdica Cardiovascular and Rspiratory Scincs 13, Dvlopmnt, tsting and dissmination of Communication stratgis and tools for vidnc basd Informd Dcision making in Italy (DCID.It) Lazio Clinicoassistnzial Halthcar Dlivry and Mthodologis 13, Infantil mitochondrial lukoncphalopathis: charactrization of nw phnotyps and idntification of novl disas gns CARLO BESTA Biomdica Gns, Gnoms and Gntics 13, Pagina 70 di 228

71 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idntification of novl diagnostic and thraputical targts in th managmnt of patints with polyps and colorctal carcinoma SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational 13, Prvnting mrgnc and transmission of multirsistant bactria in hospitalizd childrn: multi stratgy study of risk factors and ffctivnss of a tailord intrvntion OSPEDALE BAMBINO GESU' Clinicoassistnzial Infctious Disass and Microbiology 13, Prsonalizd multidisciplinary thrapy in had and nck cancr basd on clinical and molcular markrs C.R.O. AVIANO Biomdica Oncology 1 Basic Translational 13, ROLE OF ADIPOSE TISSUE IN THE PANCREATIC CANCER MICROENVIRONMENT Vnto Biomdica Oncology 1 Basic Translational 13, Pathognsis of Shiga toxin producing Eschrichia coli infctions: study of th kintics of Shiga toxins in th blood of infctd patints with bloody diarrha (hmorrhagic colitis) and/or hmolytic urmic syndrom, aimd at bttr undrstanding th mod Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 13, Disscting host pathogn intrplay: a systms biology approach to discovr Plasmodium falciparum and Anophls gambia intractors Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 13, Pagina 71 di 228

72 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Microglia/macrophags as cllular targt of novl CXCR4 antagonist and radiothrapy combind tratmnt in glioma modls Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 13, : RELATIONSHIP OF GLUCAGON LIKE PEPTIDE 1 WITH DEPRESSION AND COGNITIVE DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES. Toscana Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 13, A novl TRAIL basd thraputic by Msnchymal clls TARgting PAncratic Cancr (TARPAC) Emilia Romagna Biomdica Oncology 1 Basic Translational 13, Ergot alkaloids in crals: occurrnc, ffct of procssing and xposur assssmnt of th Italian consumr Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior 13, Mtabolomic profil of abdominal adipos tissu as a tool to idntify th ffct of ndocrin disruptors in human obsity: a potntial clu for diagnostic and thraputic approach. AUXOLOGICO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 13, Analysis of th intrplay btwn oxidativ strss and familiarity for atrial fibrillation Lazio Clinicoassistnzial Cardiovascular and Rspiratory Scincs 13, Ochratoxin A in gratd chs: occurrnc, study of surfac migration, risk managmnt and rgulatory activity proposal IZSLER Biomdica Vtrinary 13, Pagina 72 di 228

73 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Assssing th rlvanc of a targtorgan spcific mirna signatur in typ 1 diabts and in othr organ spcific autoimmun disass SAN RAFFAELE MILANO Biomdica Immunology 13, BIOENGINEERING OF A NOVEL CORNEAL DEVICE COLONIZED BY AUTOLOGOUS CELLS FOR TREATMENT OF DEEP CORNEAL PATHOLOGIES SAN RAFFAELE MILANO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 13, MicroRNA rgulation in th pathognsis of MD and in th mchanism of action ofantidprssant drugs FATEBENEFRATELLI Biomdica Gns, Gnoms and Gntics 13, Human nural stm/prognitor clls drivd from inducd pluripotnt stm clls (hinscs) as a rnwabl sourc of transplantabl nurons and oligodndrocyts. SAN RAFFAELE MILANO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 13, Cutanous and utrin lyomyomatosis occurrnc and fumarat hydratas gn xprssion: a potntial nw diagnostic algorithm for th scrning of th risk of cavrnomas and crbrovascular accidnts Lazio Clinicoassistnzial Risk, Prvntion and Halth Bhavior 13, Rgnrativ Ntworks: Influnc of adipos drivd stromal fraction on skin rpair SAN GALLICANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 13, Pagina 73 di 228

74 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Analysis of somatic mutations and rlatd altrd pathways for th idntification ofnw biomarkrs and molcular targts in tumors of th lowr fmal gnital tract PASCALE Clinicoassistnzial Gns, Gnoms and Gntics 13, Th inflammasom inducr IFI16, an alarmin that initiats and propagats inflammation in Inflammatory Bowl Disas and its rol as biomarkr of disas phnotyp htrognity and rspons to thrapy. SAN DONATO Biomdica Digstiv, Kidny and Urological Systms 13, Pr clinical and clinical (phas I) invstigation on th rol of umbilical cord wall drivd msnchymal stromal clls (UC MSC) to trat svr grad III/IV stroid rsistant acut graft vrsus host disas (GVHD) Lombardia Clinicoassistnzial 13, Prsistnt toxic pollutants (PTS) in Mditrranan safood: Analysis of tim trnds and ditary xposur risk assssmnt [MdFoodRisk] Istituto Suprior di Sanita' Biomdica Vtrinary 13, Assssing Amyloid PET Pattrns in MCI patints for an improvd prdiction of Convrsion to AD Liguria Clinicoassistnzial Brain Disordrs and Nuroscinc 13, Augmntation of nrv rgnration by iron oxid nanoparticls and lctromagntic fild: a study in rat mdian nrv lsion Toscana Biomdica Bionginring Scincs and Tchnologis 13, Pagina 74 di 228

75 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not MITOCHONDRIAL CALCIUM HOMEOSTASIS AND NEURODEGENERATION IN RODENT AND PRIMATE MODELS OF PARKINSON AND HUNGTINGTON DISEASE Vnto Biomdica Brain Disordrs and Nuroscinc 13, Cross disas Exprssion of Somatoform Phnotyps Epidmiology and Pathophysiology Abruzzo Biomdica Brain Disordrs and Nuroscinc 13, Insulin Rsistanc, Inflammation and Cardiovascular Risk: Molcular Bass, Pathophysiological, and Thraputic Implications of th High Mobility Group Protin AT Hook 1 (HMGA1) Calabria Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 13, IDENTIFICATION OF GENETIC ALTERATIONS ASSOCIATED WITH SECOND MALIGNANT NEOPLASMS HUMANITAS Biomdica Oncology 1 Basic Translational 13, Targting Mycobactrium surfac constitunts as a novl vaccination stratgy against tubrculosis aimd at dvloping nutralizing antibodis. Lazio Biomdica Infctious Disass and Microbiology 13, MOLECULAR AND IMMUNOLOGICAL PATHWAYS INVOLVED IN ONSET AND MALIGNANCY OF EXPERIMENTAL OSTEOSARCOMA AND HEMANGIOSARCOMA AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI Biomdica Oncology 1 Basic Translational 13, Pagina 75 di 228

76 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A nw modl to valuat surgical Sicilia radmission rats as hospitals' quality ofcar indicator Clinicoassistnzial Halthcar Dlivry and Mthodologis 13, Singl chain antibodis and transcription activator lik ffctor protin: a combind biotchnologis for advancd thraputic approach against HIV/AIDS Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch 13, Prsonalizd molcular mdicin in patints with dfind and undiffrntiatd autoinflammatory disass: a rational approach. GASLINI Clinicoassistnzial Immunology 13, Gnomic analysis of human mdulloblastomas and prclinical gn thrapy study to targt th rgulation of crbllar prcursor migration Lazio Biomdica Oncology 1 Basic Translational 13, Individual prdiction of urinary toxicity aftr radiothrapy of prostat cancr: incorporating clinical, dosimtric and gnomic/molcular paramtrs into prdictiv modls SAN RAFFAELE MILANO Biomdica 13, Pdiatric pilpsy: clinical and gnomic diagnosis. Application of ILAE 2013 tratmnt guidlins and validation of th rsults in pdiatric pilptic patints. Sicilia Biomdica Brain Disordrs and Nuroscinc 13, Innovativ thrapis for th rscu of intllctual disability in Down syndrom, a modl of gntic cognitiv dfct and Alzhimr's lik dmntia Campania Biomdica Brain Disordrs and Nuroscinc 13, Pagina 76 di 228

77 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not EZH2 pigntic rgulation of th HIPK2/p53/Pin1 circuitry in chmorsistant mlanoma: idntification of molcular switchs as nw thraputic targts ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Oncology 1 Basic Translational 13, Lipidomics and protomics of th skin prmability barrir vrsus blood lipidom/sphingolipidom towards th idntification of novl candidats involvd in th barrir disruption and th dsign of innovativ diagnostic tools and tratmnts in atopic drma SAN GALLICANO Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 13, Dsign of a doubl facd nanostructurd wound drssing with rgnrativ and antimicrobial proprtis Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis 13, Building a putativ univrsal modl for immun modulation of virus rlatd tumors: th rol of cll thrapy in had and nck cancr SAN MATTEO Clinicoassistnzial 13, Epigntic signatur of cardiomyocyts in modulating in th immun rspons of hart failur: a nw thraputic targt HUMANITAS Biomdica Cardiovascular and Rspiratory Scincs 13, mirna basd thraputics to targt protumorignic potntial of stromal fibroblasts in lung cancr ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 13, SYSTEMIC AND MUCOSAL CORRELATES OF PROTECTION IN HIV EXPOSED SERONEGATIVE INDIVIDUALS (HESN) Lombardia Biomdica AIDS and Rlatd Rsarch 13, Pagina 77 di 228

78 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dciphring TDP 43 proprtis in th Fronto Tmporal Dmntia/Amyotrophic Latral Sclrosis spctrum disordrs. SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 13, Innat immunity in HIV patints who do not rcovr th immun systm aftr succssful antirtroviral thrapy: th rol of th inflammasom. Emilia Romagna Clinicoassistnzial AIDS and Rlatd Rsarch 13, Crbrospinal fluid microparticls as biomarkrs of Primary Progrssiv Multipl Sclrosis: a cas control study Sicilia Biomdica Brain Disordrs and Nuroscinc 13, NOVEL AND SELECTIVE ANTITUMOR STRATEGIES FOR THE TREATMENT OF MALIGNANT MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica 13, Acoustic Spctroscopy of Lung Toscana Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 13, Exploring th link btwn antnatal matrnal dprssion and infants biobhavioral rgulation MEDEA Biomdica Biobhavioral and Bhavioral Procsss 13, Mutant p53 controls post transcriptionalmdiatd oncosupprssor mirnas maturation in colon cancr. REGINA ELENA Biomdica Gns, Gnoms and Gntics 13, Rol of CD8+CD57+ T clls in rspons to Epstin Barr Virus and in Multipl Sclrosis SANTA LUCIA Biomdica Immunology 13, Pagina 78 di 228

79 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not NEW THERAPEUTIC STRATEGIES TO IMPROVE T CELL FUNCTION BY TARGETING CO INHIBITORY RECEPTORS BY SMALL SYNTHETIC BLOCKING COMPOUNDS IN CHRONIC VIRAL INFECTIONS Emilia Romagna Biomdica Immunology 13, Halth Tchnology Assssmnt and Comparativ Effctivnss Rsarch to apprais th ral world valu of an improvd pharmacognomics assay and of a mtabolic assay for prdiction of individual rspons to th anti cancr agnt 5 Fluorouracil. Lazio Clinicoassistnzial Halthcar Dlivry and Mthodologis 13, Computr basd rhabilitation of communicativ disordrs in acquird crbral injury MAUGERI Biomdica Halthcar Dlivry and Mthodologis 13, Rol of anti LRP4 antibodis in motor nuron and nuromuscular junction altration in ALS CARLO BESTA Biomdica Brain Disordrs and Nuroscinc Th functional rol of Eukaryotic translation initiation factor 4h in Williams Burn Syndrom: sarching its dirct downstram targts. SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc Targting th Calcinurin GSK3 axis in T I. O. V. Biomdica cll acut lymphoblastic lukmia Dvlopmnt of an immunothraputic stratgy for an ffctiv thraputic HPV vaccin Istituto Suprior di Sanita' Biomdica Pagina 79 di 228

80 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ex vivo stratification of sarcoma patints who could bnfit of targtd adjuvant thrapy PASCALE Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Targting of lysophosphatidic acidmdiatd autocrin/paracrin growth signal as novl thraputic approach for livr cancr DE BELLIS Biomdica Oncology 1 Basic Translational Patho molcular mchanisms' dissction of bicuspid aortic valv: clinical and thraputic implications. Toscana Biomdica Gns, Gnoms and Gntics Cardio rspiratory ffcts in rlation to cigartt us: building a clinical and pidmiological nation wid knowldg bas Sicilia Clinicoassistnzial Risk, Prvntion and Halth Bhavior Rol of anti pilptic drugs in pilpsy and psychiatric/nurologic comorbidity: a translationalstudy. Calabria Clinicoassistnzial Brain Disordrs and Nuroscinc Cross talk btwn stromal clls, inflammation and ractiv oxygn spcis: Thir impact on cancr cll growth, survival, and cancr drug snsitivity SDN Biomdica Oncology 1 Basic Translational Rol of sirtuin 3 and its modulation in diabtic vascular disas: insights from clinical and prclinical approachs Vnto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Mtabolic Risk Profiling for Prostat Cancr Managmnt Emilia Romagna Clinicoassistnzial Population Scincs and Epidmiology Pagina 80 di 228

81 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ag rlatd Macular Dgnration: analysis of gn xprssion in th Rtina Pigmnt pithlium Choroid complx from human donors and validation of nwly idntifid gns in disasd patints. Vnto Biomdica Gns, Gnoms and Gntics Impact of intrmittnt and continuous hypoxia on factors dtrmining th dvlopmnt of athrosclrosis and cardiovascular risk in hyprtnsiv subjcts with obsity and mtabolic disordrs. AUXOLOGICO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Gut kidny axis: Rnal ffct of Mditrranan Dit and of Low protin Dit with Ktoacids to rstor th physiological intstinal microbiota in Chronic Kidny Disas (CKD) Campania Biomdica Digstiv, Kidny and Urological Systms Immun chckpoints blockad and pigntic immunomodulation: a novl thraputic approach in malignant msothlioma Toscana Biomdica Humoral and functional charactrization of xtracllular ncrnas in pathognsis of Myotonic Dystrophy typ 1 SAN DONATO Biomdica Musculoskltal, Oral and Skin Scincs EFFECTS ON THE INHALATION OF MOUNT ETNA'S VOLCANIC ASHES AND HEALTH RISK: STUDY IN VITRO OF THE POTENTIAL ALTERATIONS IN THE INNATE IMMUNOLOGIC RESPONSE AND IN THE ALVEOLAR ENVIRONMENT Sicilia Biomdica Cardiovascular and Rspiratory Scincs Pagina 81 di 228

82 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Myofibr micronvironmnt intraction as a triggr and a thraputic targt for muscl wasting in cancr cachxia. Lazio Biomdica Musculoskltal, Oral and Skin Scincs Epigntic/somatic altrations and intrcllular nuclic acids transfr associatd with an impaird control of ndognous rtrotransposabl lmnts in brast cancr: a study to invstigat pathognic mchanisms, nw prognostic disas markrs and xpri I.N.R.C.A. Biomdica Gns, Gnoms and Gntics Dit, PCDD/F, PCB, OCP, BPA, OP and NP xposur, intrautrin and arly postnatal growth, DNA mthylation and childhood obsity risk Vnto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs An intgratd ntwork of cntrs of xcllnc to prform a sris of clinical studis to assss fficacy, fficincy, safty, and appropriat clinical indications of xtracorporal mmbran oxygnation (ECMO) in patints with svr pulmonary failur Pimont Clinicoassistnzial Cardiovascular and Rspiratory Scincs Adipos tissu rlatd mchanisms and vascular dysfunction in diffrnt obs phnotyps. Lazio Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Study on th crbllar rol in Pathological Gambling: an insight into th nurobiological bass of th Impuls Control Disordrs. SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 82 di 228

83 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Influnc of diabts mllitus on tubrculosis: is autophagy dysfunction th missing link? SPALLANZANI Biomdica Infctious Disass and Microbiology Nxt gnration squncing tchniqus to idntify nw forms of inhritd thrombocytopnias and to chang th diagnostic approach to patints with low platlt count SAN MATTEO Clinicoassistnzial Vascular and Hmatology Advancd MRS, ASL prfusion and structural MRI in pdiatric migrain: a longitudinal study and corrlations with clinical and nurophysiological findings. OSPEDALE BAMBINO GESU' Clinicoassistnzial Brain Disordrs and Nuroscinc A pharmacogntic approach to sophagal cancr: constitutiv and somatic gntic variants as prdictiv, prognostic or disas risk markrs I. O. V. Clinicoassistnzial Brain and Hart (BraH): vidncs and biomarkrs that corrlat with cardiac and brain intgrity or with disas. A population basd study in th Cntnarians in Trist to prdict succssful aging. Friuli Vnzia Giulia Clinicoassistnzial Biology of Dvlopmnt and Aging Linking purinrgic P2X7 rcptor to inflammation in Multipl Sclrosis: a novl targt for thrapy. SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc RAVER2 mdiatd RNA procssing disrgulation in Autosomal Dominant Lukodystrophy Istituto Scinz Nurologich Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Pagina 83 di 228

84 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION Emilia Romagna Clinicoassistnzial THE EFFECT OF PRE TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION SAN MATTEO Biomdica Digstiv, Kidny and Urological Systms PARP inhibition as thraputic targt for Huntington's disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc IDENTIFICATION OF VASOACTIVE MEDIATORS CORRELATING WITH HEMODYNAMIC ALTERATIONS IN NEUROLOGICAL DISEASES: COMPARISON BETWEEN MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASES Toscana Biomdica Brain Disordrs and Nuroscinc 14, EPIDEMIOLOGICAL, CLINICAL AND MOLECULAR CHARACTERIZATION OF POST TRANSPLANT MALIGNANCIES: IMPLICATIONS FOR CANCER PREVENTION AND PROGNOSIS IN RECIPIENTS OF KIDNEY AND LIVER TRANSPLANTS C.R.O. AVIANO Clinicoassistnzial 14, Rol of th Plasmodium Subtilisin lik protas Sub1 in gamt grss from th host rythrocyt. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 14, Pagina 84 di 228

85 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Uncoupling protin 2 and incrasd strok suscptibility in strok pron spontanously hyprtnsiv rat. Rlvanc for th human disas. NEUROMED Biomdica Gns, Gnoms and Gntics 14, Nw thraputic options for nwborns with rtinopathy of prmaturity Toscana Biomdica Cll Biology 14, Improving Prognostic Accuracy in Svr Traumatic Brain Injury using advancd nuroimaging mthods and multivariat prognostic modling MAGGIORE Clinicoassistnzial Brain Disordrs and Nuroscinc 14, Virtual surgry to optimiz th oprativ procdur and improv th outcom in hart failur patints undrgoing surgical rshaping of th lft vntricl. SAN DONATO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 14, A markr basd approach to multimodal sophagal cancr tratmnt I. O. V. Biomdica 14, SELF REACTIVE T CELLS IN SEVERE OSTEOPOROSIS Pimont Biomdica Biology of Dvlopmnt and Aging 14, Innovativ HDACi/IFN alpha basd combination thrapy in solid tumors Istituto Suprior di Sanita' Biomdica 14, Disscting RBL2/p130 rol in apoptosis, and its intrplay with th AKT pathway, to fully xploit its tumor supprssor potntial thraputically PASCALE Biomdica Oncology 1 Basic Translational 14, Pagina 85 di 228

86 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Functional link btwn myloid supprssor clls and inhibition of protctiv T cll rsponss in mlanoma patints. GALEAZZI Biomdica Immunology 14, Idntification of small molculs activ against HIV 1 mmory T cll rsrvoirs through th inhibition of thir homostatic prolifration Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch 14, Intrautrin prvntion of prinatal and arly infancy obsity Emilia Romagna Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 14, Towards th dfinition of molcular altrations charactristic of indolnt prostat cancr: Implications for improvd slction of activ survillanc patints ISTITUTO TUMORI MILANO Clinicoassistnzial 14, Th bank vol as a novl animal modl for invstigating th prion lik proprtis of tauopathis. Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 14, Dvlopmnt of radiolabld amyloidsking agnts basd on protin and pptid scaffolds for PET imaging SAN MATTEO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 14, DEVELOPMENT OF INSULIN PRODUCING BIOHYBRID ORGAN FOR THE CURE OF TYPE I DIABETES Umbria Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 14, Pagina 86 di 228

87 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rsidual volution of HIV nv V3 squnc in virologically supprssd patints undrgoing Maravirocincluding antirtroviral thrapy. March Biomdica AIDS and Rlatd Rsarch 14, GENOTYPING OF POLYMORPHISM OF RS NOS C IN A COHORT OF MEN AFFECTED BY ERECTILE DYSFUNCTION AND ANALYSIS OF ITS IMPACT ON THE RESPONSE TO THERAPY WITH PDE5 I SAN RAFFAELE MILANO Clinicoassistnzial Digstiv, Kidny and Urological Systms 14, Dual targting of histon lysin dmthylas 1 (KDM1a) and histon dactylass (HDACs) or rtinoids with bifunctional inhibitors as novl anticancr agnts I.E.O. Biomdica Oncology 1 Basic Translational 14, Novl molcular and cllular pathophysiological mchanisms of diabtic vascular disas Abruzzo Biomdica Cardiovascular and Rspiratory Scincs 14, CDCP1 as a thraputic targt in mtastass of tripl ngativ brast cancr ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 14, Exploring th phnotypic htrognity in E200K Crutzfldt Jakob disas by intgratd association studis: a modl for improving th managmnt of nurodgnrativ disass. Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 14, Pagina 87 di 228

88 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not DISSECTION OF FATTY ACID SYNTHASE ROLE AS A DETERMINANT OF DRUG RESPONSE AND RESISTANCE IN DIFFUSE MALIGNANT PERITONEAL MESOTHELIOMA THROUGH THE INTEGRATION OF GENE AND microrna PROFILES ISTITUTO TUMORI MILANO Biomdica 14, CDKL5 rlatd nurodvlopmntal disass: a multidisciplinary study in a novl mous modl to fostr fficint thraputic approachs SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc 14, Th MINA PROJECT. Mirror Nurons In Alcoholics: can Mirror Nuron Systm hlp us toundrstand and trat Alcohol Addiction? Emilia Romagna Biomdica Brain Disordrs and Nuroscinc 14, idntification of mutatd shp prion IZSUM Biomdica Vtrinary 14, protin rsistnt to convrsion into PrPSc Mapping th multisnsory natur of th primary visual and auditory cortics with intracranial EEG and fmri CARLO BESTA Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 14, IN VITRO METABOLIC PROFILING OF EPITHELIAL OVARIAN CANCER CELLS AS A MARKER OF RESPONSE TO PLATINUM CHEMOTHERAPY I. O. V. Clinicoassistnzial 14, Dynamics of priphral blood molcular signaturs and circulating tumor clls to prdict rcurrnc in high risk tumor rsctd mlanoma patints Istituto Suprior di Sanita' Biomdica 14, Pagina 88 di 228

89 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Hospital hom clinical pathways in nurorhabilitation: cost ffctiv valuation of advancd tchnologis supporting cas managmnt and rhabilitation car NEUROMED Clinicoassistnzial Halthcar Dlivry and Mthodologis 14, Systms Mdicin & Chronic Rhinosinusitis with Nasal Polyps: Host Gnom and its Intractions with Microbiom and Environmnt SAN RAFFAELE MILANO Biomdica Infctious Disass and Microbiology 14, Biomarkrs of rspons to tratmnt in myasthnia gravis CARLO BESTA Clinicoassistnzial Immunology 14, Exploiting a cancr volatil signatur from xhald brath for brast cancr arly diagnosis ISTITUTO TUMORI MILANO Clinicoassistnzial Bionginring Scincs and Tchnologis 14, Antibodis long trm prsistnc and mmory clls rol aftr diffrnt pnumococcal vaccin stratgis in HIV adults Toscana Clinicoassistnzial Immunology 14, Prclinical valuation of Janus facd liposoms for th prvntion of infctious complications during immunomodulatory thrapy in autoimmun disass. Lazio Biomdica Immunology 14, Enabling BCI assistd bdsid dtction of intntion to communicat and communication in functional Lockd in syndroms aftr acquird brain injury SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 14, Pagina 89 di 228

90 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rol of ovarian cancr micronvironmnt and rlatd inflammatory and mtabolic changs in th pathognsis of patint's symptoms. Translational rsarch for th implmntation of a mchanism basd tratmnt approach. Sardgna Biomdica 14, Th tumorignic potntial of cancr stm clls and th influnc of inflammasom activation in th pathophysiology of cholangiocarcinoma. March Biomdica Oncology 1 Basic Translational 14, Exprssion and function of P2 rcptors in human psoriatic kratinocyts. Study of thir rol in psoriasis pathognsis and rsarch of nw potntial thraputic targts ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Musculoskltal, Oral and Skin Scincs 14, Nuclotid Excision Rpair and Acclratd Vascular Aging ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Biology of Dvlopmnt and Aging 14, Rmot controlld monitoring and clinical clustring of gait and postur disordrs in Parkinson Disas: an ovrlapping modl inst btwn individual falls rmitting and social rlapsing. Lazio Clinicoassistnzial Brain Disordrs and Nuroscinc 14, Idntification of novl biomarkrs prdictiv of rspons to mitotan in patints with adrnocortical carcinoma to implmnt a prsonalizd adjuvant tratmnt. Pimont Biomdica 14, Pagina 90 di 228

91 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Hmorhological disordrs and diabts mllitus: th Progtto Diabt Calabria Study. Calabria Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 14, Effctivnss of a cognitiv bhavioral and lifstyl intrvntion in rducing cardiovascular risk factors and cardiovascular morbidity among patints with svr mntal illnss tratd with antipsychotics Lombardia Clinicoassistnzial Risk, Prvntion and Halth Bhavior 14, Utility of liquid biopsy in th managmnt of arly stag and advancd colorctal cancr (CRC) Sicilia Biomdica 14, Cogan's Syndrom: application of functional nuroimaging to autoimmun crbral vssls' inflammation Emilia Romagna Clinicoassistnzial Immunology 14, Nw radiolabld thranostic agnts targting molcular pathways rsponsibl for mtastatic sprad PASCALE Biomdica Oncology 1 Basic Translational 14, PREDICTING FALLS AT HOME USING AN INTEGRATED ECG EMG EEG PAIN SENSORS (EEEPs) DETECTION SYSTEM NOT FALL Puglia Biomdica Emrging Tchnologis and Training in Nuroscincs 14, Immunologic and complmnt activation mchanisms for antibody mdiatd rjction and mixd rjction in hart and kidny transplantation: th rol of molcular biomarkrs for diagnostic, prognostic and thraputic stratgis. Vnto Clinicoassistnzial Cardiovascular and Rspiratory Scincs 14, Pagina 91 di 228

92 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not mirna signatur of arly nuroglial involvmnt in th rtina of diabtic patints. BIETTI Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 14, Intstinal microbiota and chronic inflammatory disas in childrn Toscana Biomdica Infctious Disass and Microbiology 14, Mnopaus: Impact on cardiovascular Risk AugmntatioN and Outcom worsning (MIRANO) Study Vnto Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 14, Th xposom of soccr playrs: valuation of potntial halth risks associatd with xposur to Substancs of Vry High Concrn (SVHC) idntifid in th framwork of th REACH Rgulation and to othr chmicals of concrn. Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior 14, THE TASTE OF BACTERIA : Idntifying th TAS2R38 gnotypic risk of rcurrnc of uppr rspiratory infctions. Campania Biomdica Infctious Disass and Microbiology 14, Rlasing th immun braks to nhanc th powr of anticancr vaccins for th tratmnt of HER2+ cancr patints" Pimont Biomdica Cration of a nw nxt gnration panl Associazion Oasi Maria SS Biomdica for th diagnosis of Mitochondrial disordrs with nuromuscular phnotyp Gns, Gnoms and Gntics Pagina 92 di 228

93 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not ObSity And rnal Function in pediatric ag: an pidmiological study in th CAlabrian rgion invstigating Rnal dysfunction in ovrwight/obs adolscnts. Th SAFEGUARDCKD projct. Calabria Clinicoassistnzial Biobhavioral and Bhavioral Procsss Immun and DNA rpair rlatd gn signaturs for th prdiction of risk of tumour rcurrncs and brain mtastasis in HER2 positiv brast cancr patints HUMANITAS Biomdica Th first Moyamoya disas Italian Ntwork: th intgration of clinics with gntic and cllular approachs for undrstanding th pathophysiology of this rar and complx disas CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc Rol of th stromal drivd factor 1 (SDF Toscana Biomdica Cll Biology )/CXCR7 cross talk btwn human hpatic stllat clls (hhsc) and cholangiocarcinoma (CCA) clls: a nw targt for CCA thrapy? Th prognostic valu of noangiognsis in Colo Rctal Cancr (CRC): a combination of stablishd and innovativ prob basd Confocal Lasr Endomicroscopy (pcle) approachs C.R.O. AVIANO Clinicoassistnzial Thr dimnsional musculoskltal ultrasound in juvnil idiopathic arthritis (JIA): dvlopmnt of a nw, fasibl tool for th assssmnt of disas activity and to support clinical dcisions and thraputic stratgy OSPEDALE BAMBINO GESU' Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Pagina 93 di 228

94 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Study of th HIV 1 cllular rsrvoir: impact of antirtroviral thrapy on HIV 1 DNA forms and idntification of archivd dfctiv viral variants. SAN MATTEO Clinicoassistnzial AIDS and Rlatd Rsarch A nw insight into th rol of aging in smoking rlatd disass: a study of cll snscnc and inflammation in Chronic Obstructiv Pulmonary Disas (COPD) and Idiopathic Pulmonary Fibrosis (IPF) Vnto Biomdica Cardiovascular and Rspiratory Scincs Nw Diagnostic and Thraputic Approachs To Prclampsia: Matrnal Circulating Biomarkrs for Early Diagnosis, Micronutrints Supplmntation and placntal drivd molcular tools Against Placntal Hypoxia, Oxidativ Strss and Endothlial Damag. Pimont Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs EARLY START EXERCISE TRAINING AFTER ACUTE HEMODYNAMIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE. A RANDOMIZED, CONTROLLED TRIAL ON FEASIBILITY AND SHORT AND MEDIUM TERM IMPACT ON FUNCTIONAL CAPACITY, SYMPTOMS AND REHOSPITALIZATIONS. MAUGERI Clinicoassistnzial Cardiovascular and Rspiratory Scincs DIMCAT: Don Gnocchi ICF Info Multicntr Application Trial DON GNOCCHI Clinicoassistnzial Halthcar Dlivry and Mthodologis Pagina 94 di 228

95 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Inflammasom and bladdr cancr: impacts on diagnosis and post surgical managmnt Umbria Biomdica Transmissibility and clinical significanc of Mycobactrium abscssus in patints with cystic fibrosis MAGGIORE Biomdica Infctious Disass and Microbiology Mutations of cytochrom c associat with rspiration dfcts and pculiar altrations of apoptotic pathways: pathogntic implications in Thrombocytopnia 4 and Mylodysplastic Syndroms. SAN MATTEO Biomdica Vascular and Hmatology Improving aphasia rhabilitation: Nw tools for administring and dircting thrapy SANTA LUCIA Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc Nuropptid Y as rgulator of macrophag phnotyp and functions: a nuroimmun cu in athrosclrosis rgrssion? Istituto Suprior di Sanita' Biomdica Immunology Xno fr nural crst drivd human stm clls from oral tissu as a nw tool for th modling and tratmnt of Multipl Sclrosis: towards prsonalizd mdicin in nuroinflammatory/nurodgnrativ disordrs. Abruzzo Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Pagina 95 di 228

96 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dndritic clls basd immun tratmnt in HIV 1 infctd patints from th Intrnational Consortium of DC Vaccin: whol gnom and functional xprssion analyss BURLO GAROFALO Biomdica AIDS and Rlatd Rsarch Nw stratgis for thraputic and clinical car in human glioblastoma NEUROMED Biomdica Brain Disordrs and Nuroscinc Us of nxt gnration squncing basd mtagnomic approach to improv th tiologic diagnosis of acut non bactrial mningoncfalitis SPALLANZANI Clinicoassistnzial Infctious Disass and Microbiology Tlhalth srvics for hom basd managmnt of patints with cardiovascular disas: multidimnsional assssmnt of Rmot Monitoring in Disas Managmnt Programs. Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis Involvmnt of cytosklton protins in mdiating pulmonary nurondocrin tumors clinical prsntation and progrssion HUMANITAS Biomdica Oncology 1 Basic Translational Prvntion of colorctal cancr with lowdos aspirin and mtformin in high risk subjcts. Liguria Clinicoassistnzial Cyclic joint loading and molcular cartilag homostasis: towards th dsign of rhabilitation programs limiting progrssion of human kn ostoarthritis RIZZOLI Biomdica Musculoskltal, Oral and Skin Scincs Pagina 96 di 228

97 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not CCR5 spcific antibody drivd mimtic pptid against HIV transmission SAN RAFFAELE MILANO Biomdica AIDS and Rlatd Rsarch A study dsignd to rplicat th wholxom squncing mdiatd idntification of novl variants involvd in inhibitor dvlopmnt in svr Italian Hmophilia A patints MAGGIORE Biomdica Gns, Gnoms and Gntics Exploiting th p53 pathway: Molcular mchanisms of th incrasing risk of brast cancr associatd with aging I.E.O. Biomdica Biology of Dvlopmnt and Aging BRAIN NETWORK DEGENERATION ASSESSED USING MULTIMODAL MRI TO EXPLAIN CLINICAL VARIABILITY IN ALZHEIMER'S DISEASE SAN RAFFAELE MILANO Clinicoassistnzial Biobhavioral and Bhavioral Procsss From nocicption to pain in disordrs of consciousnss (DoC) following svr acquird brain injury (ABI) SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Study of th intractions btwn lntiviruss and transposabl lmnts Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch A POPULATION BASED STUDY ON THE RELATIONSHIP BETWEEN EXPOSURE TO OUTDOOR AIR POLLUTION AND CIRCULATING BIOMARKERS. MAGGIORE Clinicoassistnzial Cardiovascular and Rspiratory Scincs Pagina 97 di 228

98 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Gastric cancr in th ag of prcision mdicin: Linking gnomic altrations to targtd drug rspons to validat novl thraputic stratgis Istituto Oncologico Candiolo Biomdica Safty and ffctivnss of a nw xoskltal robotic dvic for hand motor rcovry aftr strok. Toscana Biomdica Bionginring Scincs and Tchnologis Tumor and immun clls cross talk in ostosarcoma: additional tratmnt opportunitis RIZZOLI Biomdica Oncology 1 Basic Translational GAIT ROBOTIC REHABILITATION IN CHILDREN WITH CONGENITAL OR ACQUIRED BRAIN INJURIES OSPEDALE BAMBINO GESU' Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs Establishmnt of a clinical and biological (biobank) rgistry for chronic migrain: from knowldg of th phnomnon to implications for public halth Emilia Romagna Clinicoassistnzial Population Scincs and Epidmiology Priphral nrvous systm involvmnt and nuropathic pain in immunoglobulin light chain (AL) amyloidosis: pidmiology and idntification of novl "omic" markrs for diagnosis, outcom prdiction and rspons assssmnt SAN MATTEO Clinicoassistnzial Effcts of continuous and intrmittnt long trm ltrozol administration on cognitiv function in post mnopausal brast cancr patints I.E.O. Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 98 di 228

99 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A multiparamtric and risk basd monitoring approach to support clinical dcision in pdiatric cardiac intnsiv car OSPEDALE BAMBINO GESU' Clinicoassistnzial Cardiovascular and Rspiratory Scincs Extnsiv gntics and functional nuroimaging in ALS: rvaling mchanisms of disas progrssion (GNuPro ALS). IRCCS AOU San Martino IST (Gnova) Biomdica Gns, Gnoms and Gntics Patint Spcific Inducd Pluripotnt Stm Clls for Amyotrophic Latral Sclrosis drug scrning Pimont Clinicoassistnzial Brain Disordrs and Nuroscinc Prognostic valu of lung ultrasound in patints admittd for congstiv hart failur: a prospctiv obsrvational study Lombardia Biomdica Cardiovascular and Rspiratory Scincs Innovativ targtd thrapy for th tratmnt of B cll lukmia BURLO GAROFALO Biomdica Occupational skin disass: prvntiv masurs and individual suscptibility Friuli Vnzia Giulia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Idntification and validation of gns that control cllular plasticity, as novl cancr thraputic targts. I.E.O. Biomdica Oncology 1 Basic Translational D2 rsction and HIPEC (hyprthrmic intrapritonal chmoprfusion) in locally advancd gastric carcinoma: a randomizd and multicntric phas III study. SAN RAFFAELE MILANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring Pagina 99 di 228

100 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dsign, Synthsis and Prclinical valuation of novl pptidomimtic activ against ESKAPE pathogns and agnt of zoonosis Emilia Romagna Biomdica Infctious Disass and Microbiology In vivo molcular and imaging prdictors of dmntia in parkinsonism Toscana Clinicoassistnzial Brain Disordrs and Nuroscinc Efficacy of Albumin Rplacmnt and Balancd Solution in Patints with Sptic Shock (th ALBIOSS BALANCED trial): a 2 by 2 factorial, invstigator initiatd, opn labl, multicntr, randomizd, controlld trial. MAGGIORE Clinicoassistnzial Infctious Disass and Microbiology Can multi paramtric Magntic Rsonanc Imaging (mp MRI) rduc ovrdiagnosis and ovrtratmnt in scrning for Prostat Cancr? An onarm pilot study in th Flornc ara. Toscana Clinicoassistnzial 15, Molcular, immunological and imaging dtrminants of outcom in sorafnibtratd patints with hpatocllular carcinoma Emilia Romagna Biomdica 15, Targting attntion biass in dprssion: A longitudinal fmri study SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc 15, Idntification and targting of high risk subgroups in pdiatric acut lymphoblastic lukmia: Ph lik and Down Syndrom ALL Lombardia Biomdica 15, Pagina 100 di 228

101 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Cll thrapy clinical trial with Msnchymal Stm Clls (MSCs) as vhicl to dlivr paclitaxl for th tratmnt of lung mtastatic tumours in dogs IZSSI Biomdica 15, Innovativ approach to HIFU tratmnts for halth car costs rduction and patint complianc improvmnt. Sicilia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 15, Prdicting th individual's potntial for functional rcovry in Multipl Sclrosis using a combind nuroimaging and clinical approach SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 15, Colon Cancr: idntification of high risk individuals through gntic scrning SAN MATTEO Biomdica Gns, Gnoms and Gntics 15, CYTOKINES, GROWTH FACTORS AND HEART RATE VARIABILY MARKERS OF JOB STRAIN. A PROPOSPECTIVE COLLABORATIVE STUDY. Friuli Vnzia Giulia Clinicoassistnzial Risk, Prvntion and Halth Bhavior 15, Rol of th Transglutaminas typ 2 (TG2) in th pathognsis of M. tubrculosis SPALLANZANI Biomdica Infctious Disass and Microbiology 15, FECAL MICROBIAL TRANSPLANTATION IN HIV INFECTED PATIENTS WITH SUB OPTIMAL IMMUNOLOGICAL RESPONSE UNDER ANTIRETROVIRAL THERAPY Lombardia Biomdica AIDS and Rlatd Rsarch 15, Pagina 101 di 228

102 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rol of Mditrranan Dit on brast cancr rcurrnc in postmnopausal womn Calabria Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 15, ROLE OF THE IL 31/IL 31R AXIS IN B CELL MALIGNANCIES GASLINI Biomdica Oncology 1 Basic Translational 15, P2RX7, a gn modifir in ALS: gntic and functional analysis of polymorphisms in a cohort of ALS patints. SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 15, Epithlial ovarian cancr: affcting tumor growth by targting abrrant mtabolism ISTITUTO TUMORI MILANO Biomdica 15, Bioractor basd rcllularization of fixativ fr dcllularizd pricardium with aortic valv drivd intrstitial clls for drivation of living hart valv bioprosthss MONZINO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 15, Hrpsvirus DNA in lowr rspiratory tract of intnsiv car unit patints: significanc and implications. Toscana Biomdica Infctious Disass and Microbiology 15, Comparison btwn hospital admission and arly discharg from th mrgncy dpartmnt of nursing hom dwlling oldr popl diagnosd with pnumonia: a randomizd clinical trial Toscana Clinicoassistnzial Halthcar Dlivry and Mthodologis 15, Pagina 102 di 228

103 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Cllular snscnc biomarkrs in priphral blood mononuclar clls (PBMC) of Alzhimr Disas I.N.R.C.A. Biomdica Brain Disordrs and Nuroscinc 15, Abrrant gns on chromosom 10 opn nw prspctivs into th molcular pathognsis of Cutanous T cll Lymphoma ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Oncology 1 Basic Translational 15, Tratmnt of Subsyndromal Dlirium and Long trm Cognitiv Dysfunction aftr Cardiac surgry. Prdictiv valu of Nurobiochmical Markrs of brain injury and Rsting Stat Functional Connctivity valuation Emilia Romagna Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc 15, An innovativ and affordabl nxt gnration squncing basd stratgy for th diagnosis of drug rsistant tubrculosis and thrapy follow up. SAN RAFFAELE MILANO Biomdica Infctious Disass and Microbiology 15, Robot assistd rhabilitation of th uppr limb: a nw prspctiv for snsory and motor training MAUGERI Biomdica Emrging Tchnologis and Training in Nuroscincs 15, Th rol of Hdghog pathway in th crbllar functionality and rsilinc SANTA LUCIA Biomdica Biobhavioral and Bhavioral Procsss 15, Atypical Hmolytic Urmic Syndrom (ahus): Exprimntal protocol of patint monitoring by combind analysis of Eculizumab lvls and its inhibitory ffct and corrlation with clinical paramtrs and C5b 9 dposits on ndothlial clls MARIO NEGRI Clinicoassistnzial Immunology 15, Pagina 103 di 228

104 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Implmntation of innovativ procdurs for th tratmnt of cortical myoclonus, using non invasiv rptitiv Transcranial Magntic Stimulation: assssmnt of clinical fficacy with standardizd scals and monitoring of th changs on cortical xcitabili CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc 15, NON CONVENTIONAL PROGNOSTIC MARKERS AND THERAPEUTICAL TARGETS IN DEVELOPMENT AND PROGRESSION OF BLADDER CANCER SAN RAFFAELE MILANO Biomdica 15, Early diffrntiation of rspondrs from non rspondrs in patints with Crohn's disas through th quantitativ analysis of tim intnsity curvs obtaind aftr microbubbl contrast agnt injction Friuli Vnzia Giulia Biomdica Digstiv, Kidny and Urological Systms 15, Targting protin actylation for nonsmall cll lung cancr thrapy: opportunitis to ovrcom drug rsistanc REGINA ELENA Biomdica 15, Application of a standardizd ERAS (Enhancd Rcovry Aftr Surgry) prioprativ pathway in rsctiv sophagal surgry: ffcts on morbility, mortality, lnght of hospital stay, costs, and quality of lif SAN RAFFAELE MILANO Clinicoassistnzial Halthcar Dlivry and Mthodologis 15, Halth Tchnology Assssmnt of advrs drug ractions: clinical, conomical and organizational impact in a rgional halth systm Lazio Clinicoassistnzial Halthcar Dlivry and Mthodologis 15, Pagina 104 di 228

105 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt of a modl for quantitativ risk assssmnt of tick born disass in Italian city parks Istituto Suprior di Sanita' Biomdica Population Scincs and Epidmiology 15, Protomic analysis of tars of patints with glaucomatous optic nuropathy: pointing towards th dvlopmnt of novl diagnostic, prognostic and thraputic stratgis for glaucoma BIETTI Clinicoassistnzial Brain Disordrs and Nuroscinc 15, Srum sialic acid binding immunoglobulin lik lctin 7 (Siglc 7) as a biomarkr of livr inflammation and fibrosis in hpatitis C and othr chronic viral infctions SAN MATTEO Biomdica Infctious Disass and Microbiology 15, Tailord chmothrapy basd on biomarkrs xprssion in malignant plural msothlioma IRCCS AOU San Martino IST (Gnova) Clinicoassistnzial 15, Cancr Rhabiltation: dfinition of a multidimnsional and multidisciplinary approach. Patint mpowrmnt and Cost analysis. REGINA ELENA Clinicoassistnzial Halthcar Dlivry and Mthodologis 15, Cyclophosphamid as sol graft vs. host disas prophylaxis in allognic hmatopoitic stm cll transplantation from HLA idntical donors: ffcts on transplant rlatd toxicity and graft vs. lukmia tumor/ffct. Pimont Clinicoassistnzial 15, Pagina 105 di 228

106 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Cord blood xpandd ndothlial prognitors in patints with untratabl critical limb ischmia: manufactur and validation of a dfinit allognic cll thrapy product, safty assssmnt in patints candidat to amputation and study of th immunological Lazio Clinicoassistnzial Vascular and Hmatology 15, Effcts of Tumor associatd Fibroblasts and tumor clls on th availability of fficint NK clls within th tumor cor: charactrization of molcular targts for thrapy in mlanoma and colon cancr IRCCS AOU San Martino IST (Gnova) Biomdica Immunology 15, Mtal on mtal hip prosthsis: Cobaltinducd nurotoxicity RIZZOLI Clinicoassistnzial Brain Disordrs and Nuroscinc 15, A prospctiv randomizd phas II III study of continuous vrsus intrmittnt Dabrafnib and Tramtinib thrapy in BRAFV600 mutatd mtastatic mlanoma patints: clinical fficacy and translational rlvanc Lombardia Clinicoassistnzial 15, Inhibition of dyskrin as a nw approach to targt ribosom biognsis and cancr cll growth Emilia Romagna Biomdica 15, Signaling ntworks in crbllar nurodgnrativ disordrs and cancr: rol of Ataxia Tlangictasia Mutatd (ATM) kinas SANTA LUCIA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 15, Pagina 106 di 228

107 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Novl biomarkrs and thrapy targts for Anaplastic Thyroid Carcinoma thrapy: th BAG3 BRAF pathway PASCALE Biomdica Oncology 1 Basic Translational 15, Computrizd Intrconnctd Infusion Safty Systms (CIISSs) for prvnting administration rrors Istituto Scintifico Romagnolo Clinicoassistnzial Halthcar Dlivry and Mthodologis 15, Immunological radication of minimal rsidual disas in multipl myloma by chckpoint blockad and unlashing anti tumor immun rsponss Pimont Biomdica 15, Functional intrplay btwn mtabotropic glutamat and nicotinic rcptors in th modulation of plastic changs of striatal dopamin rlas: implications for Parkinson's Disas. SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 15, MULTICENTRIC RANDOMIZED PHASE I.E.O. II TRIAL OF TRANSORAL ROBOTIC SURGERY (TORS) FOLLOWED BY RISK BASED DEINTENSIFIED RADIOTHERAPY VERSUS DEINTENSIFIED CURATIVE RADIOCHEMOTHERAPY FOR T1 T2 WITH MINIMAL NODAL INVOLVMENT HPV POSITIVE OROPHARYNX CANCER Clinicoassistnzial 15, Cytokins and adipokins in phnotypd COPD as inflammatory biomarkrs in rlation to xtrapulmonary manifstations and dysmtabolism. Toscana Biomdica Cardiovascular and Rspiratory Scincs 15, Pagina 107 di 228

108 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not HIV 1 rgulatory protin Nf can contribut to incrasing suscptibility to malaria and opportunistic infctions in primary human macrophag through modulation of class B scavngr rcptor CD36 xprssion. Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch 15, Tissu protomics and SILAC basd quantitativ protomic analysis of scrtom of bnign and malignant parathyroid tumors: idntification of molcular and biochmical biomarkrs for arly diagnosis of parathyroid cancr. Toscana Biomdica 15, CirculAting VEsicls: Th hiddn sits of nurodgnration (CAVE) FATEBENEFRATELLI Biomdica Brain Disordrs and Nuroscinc 15, A multidisciplinary invstigation on th arly stags of dmntia aimd to idntify oldr popl with cognitiv frailty Vnto Biomdica Brain Disordrs and Nuroscinc 15, MicroRNA: nw markrs for th diagnosis of occult hpatitis B Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 15, IMMUNOLOGICAL MECHANISMS IMPLICATED IN THE DEVELOPMENT OF HYPERTENSION AND MORPHOFUNCTIONAL MICROVASCULAR ALTERATIONS. Lombardia Biomdica Cardiovascular and Rspiratory Scincs 15, A rsarch to improv th prdictability in th mammography scrning protocol Sicilia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 15, Pagina 108 di 228

109 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Emrging rol of Torqu Tno virus (TTV) in food chain IZSME Biomdica Vtrinary 15, Fatty acids in brast milk and prinatal xposurs to mtals and organic compounds may prdict child nuropsychological scors at 18 months in a mothr child cohort of 900 Friuli Vnzia Giulia Clinicoassistnzial Population Scincs and Epidmiology 15, Validation of th Long ncrna TRPM2 AS as a Novl Prognostic Markr and Thraputic Targt in Prostat Cancr Patints with Plvic Lymph Nod Invasion SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational 15, Dciphring th Systms Proprtis of th Mitochondrial Protom in Nurodgnrativ Disass SANTA LUCIA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 15, Th PRECISE (PRocdural failure aftr CardIovascular Surgry in th Eldrly) projct SAN DONATO Clinicoassistnzial Cardiovascular and Rspiratory Scincs 15, Byond th clinical vidnc: a longitudinal study on th ffct of physical rhabilitation in th muscl synrgis and in functional brain activity in arly Parkinson Disas patints Toscana Clinicoassistnzial Brain Disordrs and Nuroscinc 15, DC vaccination combind with radiothrapy and/or prmptiv IFNalpha in mlanoma: a phas II clinical study Istituto Scintifico Romagnolo Biomdica Pagina 109 di 228

110 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idntification of nuclar micrornas affcting hmatopoitic and nuronal cll diffrntiation and tumorignsis Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Priphral blood total nuclatd clls for th tratmnt of critical limb ischmia ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Cardiovascular and Rspiratory Scincs Thraputic targts in Chronic Lymphocytic Lukmia (CLL): a study basd on micronvironmnt and lukmic B clls cross talk. IRCCS AOU San Martino IST (Gnova) Biomdica Unmasking organ confind prostat tumors with highly invasiv profil SAN RAFFAELE MILANO Biomdica Immuno modulatory mchanisms may b rlvant in shaping th bon marrow micronvironmnt in patints with primary mylofibrosis: valuation of th possibl rol of msnchymal stromal clls. SAN MATTEO Biomdica Immunology Fatty Livr Scrning: Assssing th bst ffctiv scrning program for Non Alcoholic Fatty Livr Disas (NAFLD) Sicilia Clinicoassistnzial Digstiv, Kidny and Urological Systms Th Nural Bass of Impaird Facial Emotion Rcognition in Bordrlin Prsonality Disordr Emilia Romagna Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc Exploring th rol of gntics in juvnil strok: an xom pilot study. Toscana Biomdica Brain Disordrs and Nuroscinc Pagina 110 di 228

111 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th "Eldrly Projct" aimd at th prospctiv multidimnsional assssmnt of ldrly patints with Diffus Larg B Cll Lymphoma ARCISPEDALE Clinicoassistnzial Biology of Dvlopmnt and Aging Is rmot mmory impairmnt in amnstic Mild Cognitiv Impairmnt a prdictor of convrsion to Alzhimr's dmntia? CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc Targtd xom squncing to idntify novl putativ gntic variants associatd with Gstational Diabts Mllitus Calabria Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Duchnn Muscular Dystrophy: a study of th natural history of rspiratory muscls assssd by nw noninvasiv diagnostic tchniqus MEDEA Clinicoassistnzial Musculoskltal, Oral and Skin Scincs PI3Kgamma at th intrsction btwn hyprtnsion and immun systm. NEUROMED Biomdica Vascular and Hmatology Cognition and movmnt: bhavioural and brain rsponss to a mixd cognitiv and motor training in individuals with Parkinson's disas SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Olic acid countracts cathpsin B rlatd aggrssivnss of mtastatic mlanoma Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Pagina 111 di 228

112 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Targtd glomrular dlivry of Brain Drivd Nurotrophic Factor (BDNF) to rpair podocyt cytosklton in protinuric disass. MAGGIORE Biomdica Bionginring Scincs and Tchnologis Gn xprssion profils in ovarian cancr. Focus on Sgk1 and rlatd molculs in th dvlopmnt of patint tailord thrapis. Th modulation of Sgk1 kinas activity by Sgk1 intracting pptids and small molculs forinnovativ thraputic approach Calabria Biomdica Nw stratgis for prsonalizd diagnosis and tratmnt of nphrotic syndrom in childrn. Toscana Clinicoassistnzial Digstiv, Kidny and Urological Systms P2X7 and cancr: a doubl dg sword GASLINI Biomdica Oncology 1 Basic Translational Nw thrapis for glioblastoma IRCCS AOU San Martino IST (Gnova) Biomdica Idntification of novl biomarkrs for th chckpoint inhibitor tratmnt of mlanoma patints I. O. V. Clinicoassistnzial Functional and molcular charactrization of glutamat dpndnt mchanisms rgulating brain mtabolism in Alzhimr's disas March Biomdica Brain Disordrs and Nuroscinc Pagina 112 di 228

113 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not MOLECULAR ANALYSIS AND HISTOLOGICAL CHARACTERIZATION OF MELANOCYTIC METASTATIC PHENOTYPE ACCORDING TO THE EXPRESSION OF MCAM/MUC18 CELLULAR ADHESION MOLECULE, METALLOPROTEINASES AND ANGIOGENIC FACTORS Lazio Clinicoassistnzial Th implmntation of a nw stratgy to tailor mammography scrning population to diffrnt pattrns of brast cancr risk. Lombardia Clinicoassistnzial Population Scincs and Epidmiology Variclla zostr infctions in patints on immunosupprssant thrapy: prognostic rol and valu of vaccin prvntion Puglia Clinicoassistnzial Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto A bnch to bdsid approach to th rational us of targtd thrapis in ultra rar ntitis: th cas of xtraskltal myxoid chondrosarcoma and antiangiognics ISTITUTO TUMORI MILANO Clinicoassistnzial Food safty in childrn nutrition. Exposur of young childrn to chmicals migratd from tablwar into foods: xtnsiv study on migration, risk charactrization and risk assssmnt. Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior Nw cll and rcptor suspcts in autoimmun typ 1 diabts SAN RAFFAELE MILANO Biomdica Immunology Pagina 113 di 228

114 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not IN VIVO EVALUATION OF THE ROLE OF METFORMIN IN THE TREATMENT OF ENDOMETRIAL CANCER Lazio Biomdica Targtd multipl dy dopd NIR mitting silica nanoparticls as optical imaging probs for cancr diagnostic applications BURLO GAROFALO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Vitamin D to improv cllular killing of HIV 1. SPALLANZANI Biomdica AIDS and Rlatd Rsarch Scrning for silnt atrial fibrillation in th ldrly: potntial for strok prvntion Umbria Clinicoassistnzial Halthcar Dlivry and Mthodologis Nxt gnration squncing in Nural Tub Dfcts: idntification of suscptibility gns in ordr to improv prvntion and gntic counsling GASLINI Biomdica Gns, Gnoms and Gntics Prostat Cancr Survillanc: a nw stratgy to slct and monitor patints using rpatd PSA tst and Magntic Rsonanc Imaging Istituto Oncologico Candiolo Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Looking for spontanous prion disass in wild typ bank vols: a nw animal modl for sporadic, ag rlatd, nurodgnrativ disordrs Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc Butyrat as innovativ thraputic stratgy against pdiatric obsity complications Campania Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 114 di 228

115 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Thory of mind aftr tmporal lob pilpsy surgry: A prospctiv study CARLO BESTA Clinicoassistnzial Brain Disordrs and Nuroscinc EPINEPHRINE (ADRENALINE) REFORMULATION IN IMPROVED STABILITY DRUG DELIVERY SYSTEMS, FOR INNOVATIVE USE IN EMERGENCY SITUATIONS SAN MATTEO Biomdica Bionginring Scincs and Tchnologis Complianc to clinical guidlins for pithlial ovarian cancr in rlation to patint outcom. A population basd clinical audit in th Pidmont Rgional Cancr Ntwork Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis Undrstanding Human Papillomavirus (HPV) Natural Infction in Had and Nck Cancr to Dvlop Nw Prvntiv, Diagnostic, and Tratmnt Stratgis Pimont Clinicoassistnzial CANCER IN IMMUNOCOMPROMIzED POPULATIONS: NEW SURVEILLANCE STRATEGIES FOR SOLID TUMOURS C.R.O. AVIANO Clinicoassistnzial NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES IN PATIENTS WITH ALCOHOLIC AND DYSMETABOLIC CIRRHOSIS AND ALCOHOL CONSUMPTION Emilia Romagna Clinicoassistnzial Digstiv, Kidny and Urological Systms 16, Dvlopmnt of innovativ compoundsfor th tratmnt of rnal cll carcinoma and Von Hippl Lindau Syndrom Abruzzo Biomdica 16, Pagina 115 di 228

116 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not ROLE OF THE NOVEL PROTEIN DEPDC5 IN NEURONAL PHYSIOLOGY AND PATHOGENESIS OF FAMILIAL FOCAL EPILEPSIES: POTENTIAL THERAPEUTIC IMPLICATIONS. Istituto Scinz Nurologich Biomdica Brain Disordrs and Nuroscinc 16, Standardization of innovativ mthods of molcular diagnostics for th dvlopmnt of a prognostic and thraputic prsonalizd approach to patints affctd with colo rctal cancr Lazio Clinicoassistnzial 16, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Corrlation btwn gnotypic linags and pidmiological and clinical faturs of Mycobactrium tubrculosis infctions occurring in immigrant and authochtonous population living in th urban ara of Milan, Italy. Lombardia Clinicoassistnzial Infctious Disass and Microbiology 16, Nw stratgis for diagnostic, thraputic and clinical car in Infctious and immunological disass OSPEDALE BAMBINO GESU' Biomdica Immunology 16, CONTROLLED PHYSICAL ACTIVITY, WELLNESS EDUCATION AND ACTIVE AGINGA cohort study on cardiovascular and hmodynamic rsponss to physical activity in th ldrly. Lazio Clinicoassistnzial Cardiovascular and Rspiratory Scincs 16, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Pagina 116 di 228

117 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not GENOTYPE CHARACTERIZATION IN LIQUID BIOPSIES FOR THE EARLY IDENTIFICATION OF LETHAL DISEASE IN PROSTATE CANCER PATIENTS WITH PSA PROGRESSION AFTER PRIMARY TREATMENT Lombardia Clinicoassistnzial 16, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Study of th ffct of intravnous immunoglobulin thrapy on T cll rprtoir in AChR positiv Myasthnia Gravis as a modl for prsonalizd mdicin Lazio Biomdica Immunology 16, Comparativ ffctivnss of a homcar tlmdicin intrvntion to monitor th rspiratory prformanc of patints with ALS. Friuli Vnzia Giulia Clinicoassistnzial Brain Disordrs and Nuroscinc 16, Pathogntic rol of ndothlial clls in psoriasis: idntification of thraputic targts and prdictiv factors of comorbiditis ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Musculoskltal, Oral and Skin Scincs 16, Patints and citizns involvmnt in Halth Tchnology Assssmnt Agnzia pr i Srvizi Sanitari Rgionali Clinicoassistnzial Halthcar Dlivry and Mthodologis 16, Sphingolipid inflammatory mdiators in Alzhimr disas pathognsis and sprad FATEBENEFRATELLI Biomdica Brain Disordrs and Nuroscinc 16, Th P2X7/inflammasom axis: a ky playr in adipos tissu mtabolism in halth and disas. Toscana Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 16, Pagina 117 di 228

118 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Early vrticalization using ERIGO may improv functional and cognitiv outcom following Svr Acquird Brain Injury NEUROLESI Clinicoassistnzial Brain Disordrs and Nuroscinc 16, Dndritic clls nginrd with th transcription factors IRF1 and IRF8 as an innovativ tool for novl immunothrapy stratgis. Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational 16, Strngthning th public halth through th us of bivalv molluscs as indicators of nvironmntal contamination by human activity that affct food safty IZSUM Biomdica Vtrinary 16, Modulation of TIMELESS xprssion by mir 139.5p influncs cancr cll bhavior and incrass chmosnsitivity in colorctal cancr CASA SOLLIEVO SOFFERENZA Biomdica Oncology 1 Basic Translational 16, Angiognsis impairmnt in diabts: rol of Nuclophosmin HMGB1 intraction ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Cll Biology 16, Facilitating strok rcovry through hom basd rhabilitation training SANTA LUCIA Biomdica Halthcar Dlivry and Mthodologis 16, Enriching young popl with Intllctual Disability Disordr: prsonalizd tlrhabilitation programs vrsus ordinary car. STELLA MARIS Clinicoassistnzial Brain Disordrs and Nuroscinc 16, Pagina 118 di 228

119 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Assssmnt of th rol of gns associatd with brast cancr prdisposition in th dvlopmnt of pdiatric cancrs ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 16, Dvlopmnt of diagnostic tools for foodborn viruss dtction in outbrak sttings: rapid scrning mthods and high throughput squncing for a comprhnsiv rspons IZSLER Biomdica Vtrinary 16, Impact of Digital Information and Libraris on Lvls of car, Intrvntions, and Outcoms: IDILLIO Study. Lazio Clinicoassistnzial Halthcar Dlivry and Mthodologis 16, Tlstrok plus hom tlmonitoring projct. Fasibility, rliability, impact on quality of car and halth costs of a nodal tlmdicin ntwork for a nonstop monitoring of strok patints from th acut to th chronic phas of th disas. MONDINO Clinicoassistnzial Halthcar Dlivry and Mthodologis 16, PROTECTING THE HEALTH AND DEVELOPMENT OF INFANTS SINCE THE EARLY DAYS : HUMAN VERSUS COWS MILK Campania Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 16, NEUROPATHIC PAIN IN GAUCHER DISEASE TYPE 1: CLINICAL AND MOLECULAR ASPECTS Friuli Vnzia Giulia Clinicoassistnzial Brain Disordrs and Nuroscinc 16, Pagina 119 di 228

120 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idntification of nw candidat Brugada Syndrom gns and advancd functional analysis in patint spcific inducd pluripotnt stm cll modls. SAN RAFFAELE MILANO Biomdica Gns, Gnoms and Gntics 16, A MULTICENTRE PHASE II RANDOMIZED STUDY OF FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST AND SECOND LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER 2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. REGINA ELENA Clinicoassistnzial 16, D.Ha.R.P.: Ditary Habits, Nuclar Rcptors, and Pancratic Cancr Toscana Biomdica Oncology 1 Basic Translational 16, Nuron targting of nanoparticlconjugatd sirnas to corrct th mitochondrial phnotyp in nurological disass Campania Biomdica Bionginring Scincs and Tchnologis 16, Artificial nural ntworks and risk stratification tools for syncop in th mrgncy dpartmnt Liguria Clinicoassistnzial Cardiovascular and Rspiratory Scincs 16, Rol of FDG positron mission tomography (PET) and immunological markrs in prdicting outcom in largvssl vasculitids (giant cll artritis and Takayasu artritis) ARCISPEDALE Clinicoassistnzial Vascular and Hmatology 16, Pagina 120 di 228

121 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Randomizd controlld study on th valuation of rhabilitation tratmnts for mild cognitiv impairmnt in patints with rlapsing rmitting and scondary progrssiv multipl sclrosis Istituto Scinz Nurologich Clinicoassistnzial Brain Disordrs and Nuroscinc 16, HEALTH OUTCOME AND MOLECULAR BASIS OF PRIMARY HYPOBETALIPOPROTEINEMIAS Emilia Romagna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 16, Rol of th intraction btwn nurotnsin and mtabotropic glutamat rcptors at cllular lvl: possibl involvmnt in th dvlopmnt and xprssion of lvodopainducd dyskinsia. SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 16, Gnomic and post gnomic analysis of patints with rhumatoid arthritis tratd with biological agnts complicatd by srious infctions Lombardia Biomdica Gns, Gnoms and Gntics 16, Alloimmunity and infction: insight into SAN MATTEO pathogn drivn alloractivity to dvlop prvntiv stratgis for lat kidny graft failur Clinicoassistnzial Digstiv, Kidny and Urological Systms 16, Killing rplicating and nonrplicating bacilli to fight tubrculosis Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 16, Influnc of microbioma on biological activity of CXCR4, CCR5 and CCR6 during a mucosal chronic inflammation. SAN RAFFAELE MILANO Biomdica Immunology 16, Pagina 121 di 228

122 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Frquncy, impact on th prgnancy, and long trm clinical outcoms on th mothr and th ftus of prgnancyassociatd cancrs: a rcord linkag study. MARIO NEGRI Clinicoassistnzial Population Scincs and Epidmiology 16, Lipid biomarkrs of nuroaxonal damag for disability progrssion prdiction in Multipl Sclrosis Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 16, Fasibility of LINAC basd StroBody Radiothrapy (SBRT) in 3 fractions for low to intrmdiat/low risk prostat cancr REGINA ELENA Clinicoassistnzial 16, Innovativ stratgis for ostochondral lsions tratmnt: nw stm cll sourcs and nw biomimtic polymric scaffold RIZZOLI Biomdica Musculoskltal, Oral and Skin Scincs 16, HIGH RESOLUTION GENOMIC ANALYSIS AND BIOMARKER PROFILING OF AMYOTROPHIC LATERAL SCLEROSIS Sicilia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 16, How to fac th mrgnc of multidrug rsistant carbapnmass producing Klbsilla pnumonia strains causing bactrmia/spticmia. Toscana Biomdica Infctious Disass and Microbiology 16, Italian Platform on Nurodgnrativ Disordrs of Aging. A Mta Databas of Italian Cohort studis SANTA LUCIA Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc 16, Pagina 122 di 228

123 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Diffrntial Rols of Lft & Right Antrior/Polar Prfrontal Cortx (BA 10/11) in Ral World Problm Solving S.CAMILLO Biomdica Biobhavioral and Bhavioral Procsss 16, Idntification of nw prognostic/diagnostic markrs of Nuroblastoma: ips clls basd study of Lamin A dysrgulation MULTIMEDICA Biomdica Gns, Gnoms and Gntics Ostopontin and ICOS/B7h signaling pathways as possibl targts for novl thraputic stratgis in psoriasis GALEAZZI Biomdica Immunology Whol xom squncing and inducd Pluripotnt Stm Clls tchnology: nw tools to xplor th gntic causs of intllctual disability CASA SOLLIEVO SOFFERENZA Biomdica Gns, Gnoms and Gntics Nw onst diabts aftr transplantation (NODAT) and glucocorticoids thrapy: looking for clinical, biochmical and gntics dtrminants March Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Toward a prnatal non invasiv diagnosis of Congnital Hart Disass (CHDs): idntification of arly plasmatic markrs (mirnas) Lazio Biomdica Gns, Gnoms and Gntics Effctivnss of rpatd immunizations with DNA plasmids ncoding HER 2/nu in th longtrm prvntion of mammary cancr in HER 2/nu I.N.R.C.A. Biomdica Biology of Dvlopmnt and Aging Pagina 123 di 228

124 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not COULD AN HOME BASED LONG TERM TELEMEDICINE PROGRAMME BE FEASIBLE AND REDUCE CARDIOVASCULAR RISK IN PATIENTS WITH METABOLIC SYNDROME? MAUGERI Clinicoassistnzial Halthcar Dlivry and Mthodologis Effcts of a wb controlld hom basd xrcis intrvntion in modulating ndothlial dysfunction and rlatd humoral markrs in coronary patints across th spctrum of abnormal glucos mtabolism. DON GNOCCHI Biomdica Cardiovascular and Rspiratory Scincs From gns to connctom: intractions btwn gntic, nvironmntal, cognitiv and brain factors in patints with prclinical and clinical Alzhimr s Disas. SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc A doubl blind randomizd controlld placbo trial to valuat th fficacy of oral ttrabnazin and trihxyphnidyl in patints with dyskintic crbral palsy STELLA MARIS Clinicoassistnzial Brain Disordrs and Nuroscinc Mitochondrial functional Indx through Translational approach focusd on Oxidativ mtabolism SAN GALLICANO Biomdica Cll Biology Evaluating Atrial Fibrillation and Rlatd Outcoms Using a Validatd Halthcar Databas. Effctivnss of Nw vs Old Anticoagulants and Physicians' Prscription Bhavior. Umbria Clinicoassistnzial Population Scincs and Epidmiology Pagina 124 di 228

125 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Exploiting Rho GTPas signaling: a novl thraputic avnu in th tratmnt of Fragil X Syndrom Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc NEURO SCD: Suddn Cardiac Dath (SCD) and Nuropsychiatric drugs consumption. Lazio Clinicoassistnzial Cardiovascular and Rspiratory Scincs MICROTISSUE PRODUCTION FROM HUMAN GLIOBLASTOMA STEM CELLS: A NEW PRECLINICAL MODEL TO INVESTIGATE NOVEL TARGETS FOR PRECISION TREATMENTS Istituto Scintifico Romagnolo Biomdica Oncology 1 Basic Translational A randomizd controlld trial of a psychosocial INTERvntion on rlaps prvntion in patints in th first 5 yars from psychosis onst and thir rlativs in th VENEto rgion: fasibility, ffctivnss, prdictors of outcom and impact on Mntal Halt Vnto Clinicoassistnzial Biobhavioral and Bhavioral Procsss Prdictiv biomarkrs of rspons to PARP 1 inhibition as thraputic stratgy to improv DNA damaging agnts fficacy in bon and soft tissu sarcomas Istituto Oncologico Candiolo Biomdica Validation of novl assays to dtrmin HIV nutralization and to masur th virus rsrvoir, ky biomarkrs of thraputic fficacy and clinical outcom, for us in th clinical practic SAN GALLICANO Biomdica AIDS and Rlatd Rsarch Pagina 125 di 228

126 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Non Alcoholic Fatty Livr Disas (NAFLD), vitamin D and cardiomtabolic risk: a proof of concpt study Lombardia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Idntification of signalling pathway activation profils in colorctal cancr stm clls by mass cytomtry and corrlation with snsitivity to pathwaytargting drugs. Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Antimicrobial stwardship and dvlopmnt of nw laboratory procdurs to assss biofilm production and drug rsistanc for nosocomial survillanc and prvntion of halthcar associatd infctions SAN GALLICANO Biomdica Infctious Disass and Microbiology Molcular bass of host pathogn intraction in brucllosis: comparativ study in dairy larg ruminants. IZSME Biomdica Vtrinary Th dvlopmnt of a nw systm to optimiz th tratmnt of Cystic Fibrosis in adults: intllignt polymric nanovctors and microcapsuls to ovrcom mucus barrir. A translational rsarch to satisfy a still unmt mdical nd. Pimont Biomdica Bionginring Scincs and Tchnologis Molcular bass for th idntification of novl clinical approachs in patints with HPV inducd cancr REGINA ELENA Clinicoassistnzial Pagina 126 di 228

127 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Transcranial dirct currnt stimulation (tdcs) and spch thrapy in Primary Progrssiv Aphasias (PPA) FATEBENEFRATELLI Biomdica Brain Disordrs and Nuroscinc Mchanical vntilation guidd by osophagal prssur in svr burn patints. Pimont Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring A randomizd approach to dfin th bst tratmnt stratgy for prostat cancr patints with lymphnodal rcurrnc: prsonalizd thrapis or androgn dprivation thrapy? SAN RAFFAELE MILANO Clinicoassistnzial Endocrin valuation in patints with traumatic brain injury. Study corrlation btwn ndocrin paramtrs, body composition, and nurocognitiv, nurobhavioral and quality of lif aspcts SDN Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Fasibility of ntwork among Hospitals to provid a high quality, cost ffctiv frtility prsrvation with ovarian tissu banking to girls and womn undrgoing gonadotoxic tratmnts. IRCCS AOU San Martino IST (Gnova) Clinicoassistnzial Halthcar Dlivry and Mthodologis Assssmnt of th diagnostic valu of novl protomic biomarkrs within salivary microvscicls for th arly noninvasiv diagnosis of primary Sjögrn s syndrom Toscana Biomdica Musculoskltal, Oral and Skin Scincs Pagina 127 di 228

128 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Brain mapping in aslp conditions in th tratmnt of high grad gliomas in th languag aras CARLO BESTA Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring ROLE OF HLA AND NATURAL KILLER CELL RECEPTORS IN THE OUTCOME OF CYTOMEGALOVIRUS (CMV) INFECTION: GENETIC AND FUNCTIONAL ANALYSIS OF KILLER IMMUNOGLOBULIN LIKE RECEPTORS (KIR), HLA AND NKG2 RECEPTORS VARIANTS IN THE CONTROL OF CMV INFECTION Sicilia Biomdica Gns, Gnoms and Gntics MicroRNAs in xhald brath condnsat and plasma: novl non invasiv biomarkrs for nonsmall cll lung cancr diagnosis. MAGGIORE Biomdica Oncology 1 Basic Translational Msnchimal stromal clls for congnital and acquird skin lsions. Translational rsarch in pdiatric surgry SAN MATTEO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring A thr yar rsarch projct conductd in a pdiatric hospital cardiology unit dsignd to invstigat whthr activly liciting prfrncs and wishs in young patints with hart failur and thir parnts in vidnc basd diagnostic and thraputic o OSPEDALE BAMBINO GESU' Clinicoassistnzial Halthcar Dlivry and Mthodologis Dvlopmnt of miniaturizd assays for th timly diagnosis of rar disass Pimont Biomdica Musculoskltal, Oral and Skin Scincs Pagina 128 di 228

129 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dysrgulatd JAK function in acut lymphoblastic lukmia Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Biotchnological ragnts combind with plasmonic and nanomchanical snsors for improvd foodborn viruss dtction IZSLER Biomdica Bionginring Scincs and Tchnologis Rol of th motor cortx in th pathognsis of th Amyotrophic Latral Sclrosis disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Rmot ischmic prconditiong in patints undrgoing non cardiac surgry. A multicntr randomizd trial. SAN RAFFAELE MILANO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Assssing th in vivo fficacy of pptid thraputics towards th progrssion of Amyotrophic Latral Sclrosis MAUGERI Biomdica Brain Disordrs and Nuroscinc Unravling th molcular mchanisms that undrli brain mtastasis formation from brast cancr. I.E.O. Biomdica Oncology 1 Basic Translational METABOLOMIC ANALYSIS IN HUMAN URINE TO IDENTIFY PROGNOSTIC BIOMARKERS OF PRETERM LABOR AND PRETERM PRELABOUR RUPTURE OF MEMBRANES. Sardgna Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs ROLE OF THE ACVR1 GENE AND THE BMP PATHWAY IN PEDIATRIC ASTROCYTIC TUMORS GASLINI Biomdica Oncology 1 Basic Translational Pagina 129 di 228

130 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idntifying if rcommndd glucos targts ar associatd with an incrasd risk on ngativ outcoms in ldrly frail patints with Typ 2 Diabts I.N.R.C.A. Clinicoassistnzial Population Scincs and Epidmiology Campania Rgistry study on Acut dcompnsatd Hart Failur (CRAHF): significanc, implmntation and rduction of clinical outcoms Campania Clinicoassistnzial Halthcar Dlivry and Mthodologis Volatil Organic Compounds analysis for arly stag lung cancr diagnosis. ARCISPEDALE Biomdica CDKL5 RARE DISEASE: CHARACTERIZATION OF THE DISORDER AND DEVELOPMENT OF THERAPEUTIC STRATEGIES Istituto Scinz Nurologich Biomdica Brain Disordrs and Nuroscinc 17, Gn ntworks controlling motor nuron dgnration in spinal muscular atrophy for th dvlopmnt of nw thraputic stratgis: a comparativ transcriptomic approach basd on inducd pluripotnt stm clls and mous modls MARIO NEGRI Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 17, Rduction/limination of xposur to ionizing radiation in intrvntional lctrophysiologyprocdurs in childrn using tchnology basd on 3D mapping systms OSPEDALE BAMBINO GESU' Clinicoassistnzial Cardiovascular and Rspiratory Scincs 17, Pagina 130 di 228

131 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Markrs and Biofilm Rlatd Infction DiaGnostic Evolution [M BRIDGE]: dvlopmnt of a nw platform for prosthtic and joint infctions GALEAZZI Biomdica Infctious Disass and Microbiology 17, Effcts of snsory stimulation on cognitiv prformanc in normal subjcts and in brain injurd patints: an ERP analysis Toscana Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 17, FOODBORNE BOTULISM IN ITALY: IMPROVEMENT OF MEASURES FOR DIAGNOSIS, PREVENTION AND CONTROL OF THE DISEASE Istituto Suprior di Sanita' Biomdica Vtrinary 17, Novl pharmacological stratgis for Wilson's disas cur: corrction of mutant ATP7B protins through supprssion of intracllular dgradation procsss. From thrapy to pathognsis of damag inducd by coppr accumulation. Campania Biomdica Cll Biology 17, Nw Doxorubicin hpatic dlivry stratgy by ultrasound microbubbls and sonoporation, and ffcts of hm oxygnas 1 induction and inhibition, in th tratmnt of hpatocllular carcinoma (HCC) in rats: valuation of antinoplastic ffcts, prvntion o Vnto Biomdica 17, Food Safty and Endocrin Disruptors: a) lvls of Bisphnols into cannd food and bvrags producd in Italy and b) dirct risk assssmnt for humans IZSME Biomdica Vtrinary 17, Pagina 131 di 228

132 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not FIBRIN CLOT PROPERTIES, FIBRINOGEN OXIDATION AND OXIDATIVE STRESS IN ISCHEMIC STROKE: AN `IN VIVO' STUDY IN THE ACUTE PHASE AND AFTER INTRAVENOUS AND INTRA ARTERIAL TROMBOLYSIS Toscana Biomdica Vascular and Hmatology 17, Implmntation and valuation of th Mting Cntrs Support Programm for popl with dmntia and thir carrs (MCSP): cost ffctivnss in Italy DON GNOCCHI Clinicoassistnzial Halthcar Dlivry and Mthodologis 17, MESENCHYMAL STROMAL CELLS BEHAVIOR IN DIFFERENT JOINT ENVIROMENTS TO DEVELOP POTENCY ASSAYS STRATEGIC FOR CLINICAL APPLICATION IN RHEUMATIC DISEASES RIZZOLI Biomdica Musculoskltal, Oral and Skin Scincs 17, Fluorscnc guidd surgical rsction of high grad gliomas with sodium fluorscin: a phas III clinical trial CARLO BESTA Clinicoassistnzial 17, Nw Computational Tools for Patint Safty in IntraOprativ Elctron Radiation Thrapy Umbria Biomdica 17, Idntification of novl molcular mchanisms and implmntation of nw diagnostic tools for growth disordrs, invstigatd by using high throughput gnom approachs AUXOLOGICO Biomdica Gns, Gnoms and Gntics 17, Pagina 132 di 228

133 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Oropharyngal dysphagia in Myotonic Distrophis: diagnosis, managmnt and implications for clinical practic and rsarch CARLO BESTA Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 17, Cost analysis of managmnt of ldrly sub acut strok patints in Italy; halthcar costs rduction and quality lif bnfits on strok patints using a ICT program of th trtiary prvntion of cognitiv dclin and motor function through cognitiv fun SAN RAFFAELE PISANA Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs 17, RESPIRATORY GATED DEEP INSPIRATION BREATH HOLD AND SURFACE IMAGING FOR RADIOTHERAPY OF LEFT SIDED BREAST CANCER Pimont Clinicoassistnzial 17, Environmntal and allrgic factors affcting th prvalnc and th diagnostic thraputic approachs of asthma in childrn MARIO NEGRI Clinicoassistnzial Population Scincs and Epidmiology 17, Exosom mdiatd RNA intrfrnc: a nw thraputic stratgy for HPVinducd cancr Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis 17, Study of th rol playd by S100B and RAGE in Amyotrophic Latral Sclrosisinducd astrocytosis and motonuron dath Lazio Biomdica Brain Disordrs and Nuroscinc 17, Pagina 133 di 228

134 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Exploring th molcular mchanisms of glioblastoma stm lik cll survival and diffrntiation to dsign novl thraputic stratgis: micrornas as potntial supportrs to tumor vascularization Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational 17, EXPRESSION PROFILING IN HUMAN HORMONE SECRETING NEUROENDOCRINE TUMORS IN ASSOCIATION WITH CLINICAL AND BIOCHEMICAL FEATURES AUXOLOGICO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 17, INHIBITION OF DRUGGABLE GENE ABERRATIONS IN ER POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Emilia Romagna Clinicoassistnzial 17, Right Intrnal Thoracic Artry as Blood Supply for Saphnous Vin Bypass Graft Friuli Vnzia Giulia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 17, Hpatitis B Vaccination in HIV Positiv Adults with Isolatd Antibodis to HBV Cor Antign (Anti HBc): Evaluation of Humoral and Cllular Immun Rspons SAN RAFFAELE MILANO Clinicoassistnzial Infctious Disass and Microbiology 17, Th impact of th Intrnal Body Prcption and imag in Aging: dvlopmnt of an innovativ tool SANTA LUCIA Clinicoassistnzial Biology of Dvlopmnt and Aging 17, Pagina 134 di 228

135 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prdiction of Cardiovascular Risk by Cardiopulmonary Exrcis Tsting: th EURO(pan) EX(rcis) Population Basd Study SAN DONATO Clinicoassistnzial Cardiovascular and Rspiratory Scincs 17, A prospctiv randomizd study for outpatint managmnt of chronic hart failur: Lung Ultrasound and Noninvasiv Cntral Vnous Prssur Masurmnt as additional diagnostic tools to standard physical xamination SAN RAFFAELE MILANO Clinicoassistnzial Cardiovascular and Rspiratory Scincs 17, Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro infrior a ASSESSMENT OF DIFFERENT WHEAT CULTIVAR EFFECTS IN A MOUSE MODEL OF ENTEROPATHY Campania Biomdica Digstiv, Kidny and Urological Systms 17, Risk assssmnt for and stratgis to rduc prioprativ complications and organ damag for patints undrgoing cardiac surgry Friuli Vnzia Giulia Biomdica Cardiovascular and Rspiratory Scincs 17, Nw diagnostic and thraputic approachs in oncology basd on th UN1/CD43 tumor antign. Calabria Biomdica 17, Dcrasing nuronal cll loss in Parkinsonisms by idntifying stm cll mdiatd rparativ mchanisms: a pilot study in Progrssiv Supranuclar Palsy. MAGGIORE Biomdica Brain Disordrs and Nuroscinc 17, Ditary advancd glycation nd products and cardiovascular risk: animal and human studis Istituto Suprior di Sanita' Biomdica Cardiovascular and Rspiratory Scincs 17, Pagina 135 di 228

136 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Circulating micrornas as biomarkrs for diagnosis and prognosis of hpatocllular and cholangiocllular carcinomas Emilia Romagna Biomdica 17, Impact of dit and physical activity on quality of lif and outcom of patints opratd for lung cancr I.E.O. Clinicoassistnzial Population Scincs and Epidmiology 17, , diagnostic, pharmacological and pharmacogntic managmnt of Gambling disordr in Calabria, Italy. A prospctiv study. Calabria Clinicoassistnzial Risk, Prvntion and Halth Bhavior 17, Circulating Endothlial Prognitor Clls and Aquaporins as prdictiv biomarkrs of onst and growth of hmangioblastomas and cysts in von Hippl Lindau disas. Emilia Romagna Biomdica 17, Evaluation of changs of fcal microbioma in patints infctd/colonizd with Klbsilla pnumonia carbapnams producrs (KPC Kp) aftr th us of dcontamination protocols SPALLANZANI Biomdica Infctious Disass and Microbiology 17, Cardiac dysfunction inducd by tyrosin kinas inhibitors: from arly diagnosis to thrapy Sicilia Clinicoassistnzial Cardiovascular and Rspiratory Scincs 17, Diabts Ktoacidosis in childrn and adolscnts: an Italian nationwid study on clinical, social and conomic impact March Clinicoassistnzial Population Scincs and Epidmiology 17, Pagina 136 di 228

137 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not An approach basd on AZP531, th unacylatd ghrlin (UnAG) analogu, to improv blood flow and support skltal muscl rgnration in diabts and priphral artry disas (PAD). Pimont Biomdica Vascular and Hmatology 17, A Knowldg Translation Platform for masuring rhabilitation outcoms and cost for patints in car pathways Friuli Vnzia Giulia Clinicoassistnzial Biobhavioral and Bhavioral Procsss 17, Klbsilla pnumonia carbapnmass (KPCs) positiv strains in hospitalizd patints non rspondrs to antibiotic thrapy and without any othr thraputic option: valuation of a rscu thrapy basd on facalmicrobiota transplantation (FMT). SAN MATTEO Clinicoassistnzial Infctious Disass and Microbiology 17, Cllular and animal modls of Panthothnat Kinas Associatd Nurodgnration (PKAN): from pathognsis to drug scrning. Lombardia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 17, Markrs of disas progrssion in mtabolic and cardiovascular disass causd bymutations in lamins. RIZZOLI Biomdica Gns, Gnoms and Gntics 17, Involvmnt of gut ndothlial barrir modifications in cliac disasassociatd hyprtransaminasmia: a modl to invstigat th gut livr axis SAN MATTEO Biomdica Digstiv, Kidny and Urological Systms 17, MicroRNAs as plasma biomarkrs of carotid plaqu instability Vnto Biomdica Gns, Gnoms and Gntics 17, Pagina 137 di 228

138 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Xnotransplantation of primary cancr sampls in zbrafish mbryos: towards prsonalisd mdicin Toscana Clinicoassistnzial 17, NEW STRATEGIES FOR MUCOSAL VACCINATION AGAINST HELICOBACTER PYLORI AND CLOSTRIDIUM DIFFICILE INFECTIONS Toscana Biomdica Infctious Disass and Microbiology 17, Idntification of ncrnas as biomarkrs for arly dtction of aggrssiv prostat cancr in plasma and tissus Pimont Clinicoassistnzial 17, THE IMPACT OF INTENSIVE TUBERCULOSIS CASE FINDING WITH MOLECULAR TESTS IN HIV INFECTED PATIENTS Istituto Suprior di Sanita' Clinicoassistnzial AIDS and Rlatd Rsarch 17, Lung transthoracic US lastography imaging and contrast imaging US: a comparisonaddrssd to US guidd biopsis of subplural cancr Sicilia Clinicoassistnzial 17, Charactrization of multidrug rsistant (MDR) Klbsilla pnumonia strains in Sicilian animals compard with clinical isolats IZSSI Biomdica Infctious Disass and Microbiology 17, SCREENING FOR OSTEOPOROSIS AND FRACTURE RISK: TARGETING THE LINK BETWEEN CIRCULATING MONOCYTES AND BONE REMODELING RIZZOLI Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 17, Pagina 138 di 228

139 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Botanicals usd in products marktd for human and animal halth: phytochmical profils and thir toxicity valuation Istituto Suprior di Sanita' Biomdica Risk, Prvntion and Halth Bhavior 17, Chronothrapy in Hart Failur:Convntional vrsus Tmporizd thrapy in Hart Failur (CONVERT HF) Emilia Romagna Clinicoassistnzial Cardiovascular and Rspiratory Scincs 17, Exosoms omics: a vhicl for tumorstroma communication and clinical translation in pancratic cancr Vnto Biomdica Oncology 1 Basic Translational 17, Thraputic stratgis against Influnza virus infction basd on lactofrrindrivd pptids Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro infrior a Assssing th Risk of Falls in th Eldrly of Long trm car institutions through Instrumntal Sit to stand tst (ARFELIS) DON GNOCCHI Clinicoassistnzial Risk, Prvntion and Halth Bhavior Innovativ biotchnologis for th assssmnt of Excssiv Physical Activity (EPA), hart rat variability and strss lvls in arly adolscnts with anorxia nrvosa rstrictiv subtyp (ANR) STELLA MARIS Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 139 di 228

140 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prognostic valu of EndoPrdict (EP) scor in prmnopausal womn with nwly diagnosd ndocrin rsponsiv brast cancrs tratd with hormonal thrapy in th IBCSG (Intrnational Brast Cancr Study Group) SOFT and TEXT trials. I.E.O. Clinicoassistnzial Assssmnt of botulinum toxin ffct on skltal muscl CARLO BESTA Biomdica Musculoskltal, Oral and Skin Scincs Assssmnt of gastrointstinal comorbiditis in Autism Spctrum Disordrs (ASD) Campania Biomdica Digstiv, Kidny and Urological Systms Childhood Cancr Survivors ntring adulthood: prvalnc of chronic conditions and th Survivorship Passport as a tool for transition to adult car and follow up GASLINI Clinicoassistnzial Halthcar Dlivry and Mthodologis Rol of altrd prsynaptic protinsmdiatd synaptic plasticity in cognitiv dclin in th aging brain I.N.R.C.A. Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc USE OF LABELED MESENCHYMAL STEM CELLS AS DELIVERY VECTORS OF ANTI CANCER DRUGS Istituto Suprior di Sanita' Biomdica Evaluation of th anti tumor ffcts and mchanisms of antirtroviral drugs in crvical cancr: prclinical and human studis Istituto Suprior di Sanita' Biomdica Pagina 140 di 228

141 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Slp in Subjctiv Mmory Impairmnt NEUROMED Biomdica Brain Disordrs and (SMI) as a pr clinical stag of Alzhimr Nuroscinc Disas: a nuroimaging study Embryonal tumors of th brain: analysis of pigntic ntworks NEUROMED Biomdica Oncology 1 Basic Translational A gnom basd and functional approach to improv th diagnosis and dfin th molcular bass of syndromic and non syndromic intllctual disability. Pimont Biomdica Brain Disordrs and Nuroscinc Tailord communication stratgis to improv lifstyl habits in womn at intrmdiat/high risk of dvloping brast cancr: a Randomisd Control Trial in a scrning stting. Pimont Clinicoassistnzial Risk, Prvntion and Halth Bhavior MRI nurography assssmnt of nrv rgnration du to tratmnt in injury, comprssiv and dgnrativ priphral nuropathis. SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc BRAIN CONNECTIVITY IN EARLY POST SURGICAL PRIMARY BRAIN TUMOR PATIENTS: RELEVANCE FOR PREDICTING INTENSIVE EARLY POST SURGICAL REHABILITATION OUTCOME MAUGERI Biomdica Brain Disordrs and Nuroscinc N formyl pptid rcptors (FPRs) xprssion in Systmic Sclrosis substs a markr of fibrosis or vascular dysfunction? Campania Biomdica Immunology Pagina 141 di 228

142 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Epignomics of padiatric multipl sclrosis Sicilia Biomdica Gns, Gnoms and Gntics Prvntion of obsity through prbiotic ffct of plant drivd insulin mimtic substancs SAN RAFFAELE MILANO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Dvlopmnt of diagnostic and prognostic pigntic tools for facioscapulohumral muscular dystrophy (FSHD) NEUROMED Biomdica Musculoskltal, Oral and Skin Scincs stm clls on structural fat grafting Emilia Romagna Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Th rol of priostin in th pathognsis and progrssion of ndomtriosis and ovarian cancr ndomtriosis rlatd. Calabria Clinicoassistnzial Oncology 1 Basic Translational LIVER REGENERATION ENHANCEMENT: PRE CLINICAL AND FIRST IN MAN CLINICAL STUDY TO ASSESS THE SAFETY AND EFFICACY OF HUMAN ADIPOSE DERIVED MESENCHYMAL STEM CELLS. Sicilia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring On Halth approch to valuat Hpatitis E virus infction burdn in humans and swin in March and Lazio rgions, risk factors and pathognic potntial of diffrnt virus strain IZSUM Biomdica Infctious Disass and Microbiology Pagina 142 di 228

143 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Toll Lik rcptors (TLRs) a nw biomarkr for undrstanding oral and oro pharyngal carcinognsis and tumor progrssion rlatd to Human Papillomavirus (HPV) infction?a multicntr study on low/high grad pithlial dysplasia and cancr HPV+v vrsu Sicilia Biomdica Targting macrophag polarization to ovrcom trabctdin rsistanc in myxoid liposarcoma. Lazio Biomdica Oncology 1 Basic Translational BRADEION AS A URINARY MARKER OF TRANSITIONAL CELL CANCER OF THE BLADDER: VALIDATION BY RT PCR OF SEPT4 TRANSCRIPTS AND DEVELOPMENT OF A DIAGNOSTIC TEST Sicilia Biomdica Bta cll gns and diabts: from MODY to atypical typ 1 or typ 2 diabts Emilia Romagna Biomdica Gns, Gnoms and Gntics Validation of Nxt Gnration Squncing (NGS) basd Lysosomal Storag Disas Diagnostic Panls and Charactrisation of Novl Gn Variants by Functional Studis through Transint Gnration of Zbrafish Mutants GASLINI Biomdica Gns, Gnoms and Gntics Mtagnomic analysis of infctious agnts involvd in colon polyps and cancr as innovativ prvntion and tratmnt stratgis Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Pagina 143 di 228

144 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Molcular taxonomy of (familial) spinal nurofibromatosis Sicilia Biomdica Gns, Gnoms and Gntics A promising tratmnt option for Bisphosphonat Rlatd Ostoncrosis of th Jaw (BRONJ) basd on ostoblasts/ostoclasts co culturing on multifunctional scaffolds. Abruzzo Biomdica Musculoskltal, Oral and Skin Scincs QUANTIFICATION OF IGF 1 ISOFORMS AND ANALYSIS OF THEIR FUNCTION IN BREAST CANCER ISTITUTO TUMORI MILANO Biomdica Thraputic xploitation of corrlats of mlanoma cll rsistanc to targtd drugs through immunobiologic approachs C.R.O. AVIANO Biomdica A modl to assss th ffct of tissu ozonisation as a nw stratgy to trat ndomtriosis Friuli Vnzia Giulia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pr tratmnt Immun Activation/Exhaustion as a Factor Affcting Post cart Immun Rconstitution Lvl and Function in Naiv HIV infctd Prsons Undrgoing Tratmnt SPALLANZANI Biomdica AIDS and Rlatd Rsarch Circulating ndothlial clls (CEC) and microrna as novl biomarkrs prdicting th rspons to antiangiogntic thrapy in pithlial ovarian cancr C.R.O. AVIANO Biomdica Pagina 144 di 228

145 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Androgn xcss, hormonal rcptors, aromatas and 5alfa rductas activity, in brast cancr growth and prognosis ISTITUTO TUMORI MILANO Biomdica Anthropomtric, mtabolic, inflammatory and cntral hamodynamic paramtrs associatd to nwly diagnosd hyprtnsion, inadquatly controlld blood prssar and vascular aging in a larg sampl of gnral population: thraputic and prognostic implicati Emilia Romagna Clinicoassistnzial Cardiovascular and Rspiratory Scincs Biological aging and urban pollution Vnto Biomdica Cardiovascular and Rspiratory Scincs Rd orang juic daily consumption and human halth: a pilot study in high cardio mtabolic risk subjcts and Typ 2 Diabtic patints Istituto Suprior di Sanita' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Liquid biopsis to dtct microscopic rsidual disas and monitor its volution aftr surgry for arly brast cancr Istituto Scintifico Romagnolo Biomdica In sarch of nw drugs and drug targts for th diagnosis and thrapy of Invasiv Fungal Infctions (IFIs) Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology MULTI MODAL CHARACTERISATION OF CORTICO SPINAL TRACT LESIONS DON GNOCCHI Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 18, Pagina 145 di 228

146 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A molcular orintd approach as a slction tool for multimodal tratmnt of gastric cancr. Multicntr biomarkr validation conductd by th Italian Rsarch Group for Gastric Cancr (GIRCG) ntwork Toscana Biomdica 18, Effct of strss ( and psychological factors) on immun and ndocrin systms in patints affctd by brast carcinoma and hormon corrlatd tumours. I.N.R.C.A. Clinicoassistnzial Biobhavioral and Bhavioral Procsss 18, Ischmic Prconditioning and th vascular rspons to ischmia in chronic kidny disas (CKD) patints (PROTECT CKD) Calabria Clinicoassistnzial Cardiovascular and Rspiratory Scincs 18, Epilpsy and suddn dath: Idntification and prvntion of rlativs using gntic diagnosis Lazio Biomdica Brain Disordrs and Nuroscinc 18, Nw tchnologis for a prdictiv, prsonalizd, prvntiv and participatory (4P) mdicin in atrial fibrillation Istituto Suprior di Sanita' Biomdica Halthcar Dlivry and Mthodologis 18, Virological and molcular charactristics of Human Papillomavirus (HPV) : a study on prvalnc and prsistnc in oral cavity and ano gnital sits in HIVpositiv patints SPALLANZANI Biomdica Infctious Disass and Microbiology 18, Pagina 146 di 228

147 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Nurobiological Mchanisms Undrlying Effctivnss of Cognitiv Bhaviour Tratmnt in childhood and adolscnc Anxity Disordrs MEDEA Biomdica Biobhavioral and Bhavioral Procsss 18, Study th rpurposd drug Auranofin to find nw low cost thraputic stratgy for cancr patints ngativ and positiv for HIV infction C.R.O. AVIANO Biomdica 18, Evaluation of monoamin oxidas A (MAO) as a targt for tratmnt of Prostat Cancr. I.E.O. Clinicoassistnzial 18, A study to improv rmovabl dntur adhsion with oral mucosa: from th molcular basis to translational applications Pimont Biomdica Musculoskltal, Oral and Skin Scincs 18, LONGITUDINAL MRI STUDY IN PRE MCI SUBJECT: IMAGING BIOMARKERS OF EARLY PRODROMAL NEURODEGENERATIVE CHANGES SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc 18, Paratubrculosis in shp and goats in southrn Italy, and risk rlatd to th consumption of dairy products contaminatd by Mycobactrium avium subsp. paratubrculosis IZSLER Biomdica Vtrinary 18, Prvalnc and burdn of chronic hpatitis C virus infction in Italy: a rprsntativ nationwidstudy in th gnral population. Istituto Suprior di Sanita' Clinicoassistnzial Infctious Disass and Microbiology 18, Pagina 147 di 228

148 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Transmmbran Rcptors/Trasforming Growth Factor Bta Rcptors Biasd Crosstalk: A Novl Concpt for Nanothrapy of Cardiac Fibrosis in Hart Failur Campania Biomdica Cardiovascular and Rspiratory Scincs 18, Modna Familial Cancr Clinic: organizing an halth car srvic dvotd to assss, counsl and manag popl with hrditary cancr syndroms. Emilia Romagna Clinicoassistnzial Gns, Gnoms and Gntics 18, Estimation of human halth risk to mthyl mrcury: hair and nail as noninvasiv bio indicators. IZSPLV Biomdica Vtrinary 18, Thraputic targting of cancr stm clls and idntification of biomarkrs prdictiv of drug rspons in lung cancrs Istituto Suprior di Sanita' Biomdica 18, Sarching for nw biomarkrs in Autism Spctrum Disordrs (ASDs) by DNA mthylation profil and gn xprssion analysis of ASD discordant sibpairs Vnto Biomdica Gns, Gnoms and Gntics 18, Invstigating hparanas in synovial sarcoma as a targt of innovativ thrapis ISTITUTO TUMORI MILANO Biomdica 18, Prognostic vidnc in Halth Tchnology Assssmnt Agnzia pr i Srvizi Sanitari Rgionali Clinicoassistnzial Halthcar Dlivry and Mthodologis 18, Pagina 148 di 228

149 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not UNDERSTANDING SPACE AND ACTION PERCEPTION IN SPINAL CORD INJURED PEOPLE: NEUROSCIENTIFIC AND TRANSLATIONAL IMPLICATIONS Vnto Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 18, Alzhimr's disas as a systmic disordr: molcular targts and clinical corrlats Sicilia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 18, ICAROS Indagin sui Clustr di Aumnto dl Rischio Oncologico in Salnto Puglia Clinicoassistnzial Population Scincs and Epidmiology 18, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto EVA: Early Vascular Abnormalitis in IUGRPrnatal and postnatal dtction of cardiovascular disordrs in intrautrin growth rstrictd ftuss and nonats: a multicntric clinical and biochmical study Vnto Clinicoassistnzial Cardiovascular and Rspiratory Scincs 18, Rhabilitation for bdriddn patints: incrasing prformanc and appropriatnss by mans of cognitiv and autonomic data analysis Istituto Suprior di Sanita' Biomdica Intgrativ, Functional, and Cognitiv Nuroscinc 18, Potntial us of Circulating Mlanoma Clls (CMCs) in dog: a spontanous cancr modl for studying mtastasis IZSVE Biomdica Vtrinary 18, Pagina 149 di 228

150 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Oxidativ strss and arly prgnancy complications Lazio Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 18, Novl biomarkrs and thraputic targts for th human malignant plural msothlioma. Emilia Romagna Biomdica Oncology 1 Basic Translational 18, Molcular charactrization of lobular carcinoma of th brast and its variants. Emilia Romagna Clinicoassistnzial Oncology 1 Basic Translational 18, ExoND Cross disas idntification and analysis of xosomal cargo signatur: implication for nuroprotction and thraputics in nurodgnrativ disass. MONDINO Biomdica Brain Disordrs and Nuroscinc 18, LIPID NANOCARRIERS FOR PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 18, Dvlopmnt of novl biomarkrs for th arly diagnosis of chronic antibody mdiatd rjction in rnal transplantation Vnto Biomdica Digstiv, Kidny and Urological Systms 18, A mtabolomics approach to idntify abrrant signaling pathways in patints at risk for major cardiovascular vnts:studis in human subjcts with diabts and athrosclrosis Lazio Biomdica Vascular and Hmatology 18, Pagina 150 di 228

151 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Idntification of gntic profils associatd with IgE variability in bakrs xposd to occupational allrgns by xom squncing Vnto Biomdica Population Scincs and Epidmiology 18, Attacking amyotrophic latral sclrosis from th priphry: will th immun systm hlp to win th battl? Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 18, Study of th molcular mchanisms undrlying oncogn dpndnt DNA rplication strss I.E.O. Biomdica Oncology 1 Basic Translational 18, Early and lat graft failur in livr transplantation: impact of pr formd and d novo spcific antibodis, dfinition of histological damag and antibodis mdiatd failur and nw immunosupprssion stratgy to prvnt antibodis graft failur Emilia Romagna Clinicoassistnzial Immunology 18, Rol of HMGB1 in Doxorubicin inducd cardiotoxicity MONZINO Biomdica Cardiovascular and Rspiratory Scincs 18, Mtabolic profiling of cancr stm lik clls from glioblastoma patints: 1H NMR spctroscopic fingrprints coupld to biological, radiobiological and clinical data. Istituto Suprior di Sanita' Biomdica 18, QUANTITATIVE MRI OF THE BRAIN AND SPINAL CORD FOR THE EVALUATION OF ADRENOMYELONEUROPATHY SEVERITY AND PROGRESSION SAN RAFFAELE MILANO Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 18, Pagina 151 di 228

152 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not and molcular charactrization of corpus callosal abnormalitis: towards a bttr undrstanding of thir gntic basis. Campania Biomdica Brain Disordrs and Nuroscinc 18, Intimat Partnr Violnc and Woman's Mntal, Social and Physical Wll bing: analysis of risk factors and th bio bank for pigntic studis Liguria Clinicoassistnzial Population Scincs and Epidmiology 18, Pulmonary infctions by Psudomonas aruginosa in a third lvl padiatric univrsity hospital: study of mchanisms involvd in adaptation, virulnc, transmission, dvlopmnt of antibiotic rsistanc Toscana Clinicoassistnzial Infctious Disass and Microbiology 18, Adaptiv radiothrapy concomitant with chmothrapy in proprativ tratmnt of rctal adnocarcinoma. Dos finding and clinical fficacy of adaptiv radiothrapy; assssmnt of radiologic, functional, and gntic paramtrs prdicting pathologic complt SAN RAFFAELE MILANO Clinicoassistnzial 18, Fighting drug rsistanc in tripl ngativ brast cancr (TNBC): a combinatorial approach basd on anti Kit ligand vaccination Pimont Biomdica 18, Intgration, Harmonization and Standardization of laboratory tools for disas monitoring and outcom prdiction in non Hodgkin Lymphoma (NHL) in th contxt of th "Fondazion Italiana Linfomi" (FIL) ntwork Pimont Clinicoassistnzial 18, Pagina 152 di 228

153 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not MUTATIONAL ANALYSIS, NEOANGIOGENESIS, AND CELL LINEAGE TRACING AS NEW COMPLEMENTARY APPROACHES TO DISCRIMINATE THE RISK OF MALIGNANT TRANSFORMATION IN ADENOMATOUS LIVER LESIONS. Emilia Romagna Clinicoassistnzial 18, Zoonotic potntial and pathognic rol of th intstinal parasit Dintamoba fragilis in pigs IZSUM Biomdica Infctious Disass and Microbiology 18, Burdn of Cancr in thr Italian population basd cancr rgistris and attributabl fraction to main risk factors Istituto Scintifico Romagnolo Clinicoassistnzial Population Scincs and Epidmiology Influnc of phosphat mtabolism in th clinical phnotyp and pathognsis of bon, minral and cardiomtabolic disordrs CASA SOLLIEVO SOFFERENZA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Idntification of nw mtabolic thraputic targts of clar cll Rnal Cll Carcinoma cancr stm clls through th study of lipid and glucos mtabolism Lombardia Biomdica Oncology 1 Basic Translational Noadjuvant pptid rcptor radionuclid thrapy (PRRT) with 90Y DOTATOC in pancratic nurondocrin tumors. I.E.O. Clinicoassistnzial Short trm starvation as a stratgy to improv th fficacy of tyrosin kinas inhibitors in cancr GASLINI Biomdica Oncology 1 Basic Translational Pagina 153 di 228

154 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rol of havy mtals in th onst and progrssion of human gastrointstinal inflammation Campania Biomdica Digstiv, Kidny and Urological Systms Gntic markrs in ldrly to stimat Sicilia Biomdica Gns, Gnoms and th risk for vascular disass by using th Gntics priphral artrial disas modl No adjuvant systmic chmothrapy plus intra artrial chmothrapy plus xtrnal capacitiv hyprthrmia followd by prcutanous irrvrsibl lctroporation and than by adjuvant thrapy in locally advancd pancratic cancr: a phas 1 2 clinical trial ONCOLOGICO DI BARI Clinicoassistnzial T10 cllular immunothrapy in kidny transplantation to induc donor spcific tolranc SAN RAFFAELE MILANO Clinicoassistnzial Immunology Sarch for Markrs of Damag in Hmatopoitic Clls in patints curd aftr childhood cancr GASLINI Biomdica Oncology 1 Basic Translational Pathological biominralization: nw insights in human bioapatit dposits in th calcific aortic valv and aortic wall in th prvntion of arly calcification Vnto Biomdica Cardiovascular and Rspiratory Scincs Intstinal microbiom in Parkinson's disas: idntification of disas biomarkrs along th gut brain axis Provincia autonoma Trnto Biomdica Gns, Gnoms and Gntics Pagina 154 di 228

155 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not EXOME SEQUENCING IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) PATIENTS Emilia Romagna Biomdica Gns, Gnoms and Gntics Undrstanding th molcular bass of congnital hart dfcts: from gn discovry to molcular diagnosis OSPEDALE BAMBINO GESU' Biomdica Gns, Gnoms and Gntics MicroRNAs as a novl diagnostic biomarkrs for Non Alcoholic Fatty Livr Disas (NAFLD) and Non Alcoholic StatoHpatitis (NASH). Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Implmntation of adhrnc work up by thraputic drug monitoring (TDM) and intgratd hmodynamic status assssmnt, for th managmnt of rsistant hyprtnsion (RH) Pimont Clinicoassistnzial Vascular and Hmatology Effct of CHRNA7 gnotyps on th cognitiv rspons to actylcholinstras inhibitor (AChEI) tratmnt (Donpzil) at Diffrnt Stags of Alzhimr's Disas SAN RAFFAELE PISANA Clinicoassistnzial Brain Disordrs and Nuroscinc Intgratd multidisciplinary approach OSPEDALE BAMBINO and not convntional GESU' ndoscopic/surgical basd stratgis in padiatric morbid obsity: clinical trials and idntification of novl potntial noninvasiv biomarkrs for pr and postoprativ monitoring Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 155 di 228

156 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Non traditional biomarkrs of CKDassociatd cardiovascular disas: potntial nw avnus for prvntion and thrapy. Campania Biomdica Digstiv, Kidny and Urological Systms Intrfron rgulatory factor 4 (IRF4) in chronic lymphocytic lukmia: functional, prognostic and thraputic implications Emilia Romagna Biomdica Oncology 1 Basic Translational GERIATRIC ASSESSMENT IN THE ONCOLOGY SETTING: VALIDATION OF A MULTIDIMENSIONAL PROGNOSTIC INDEX Emilia Romagna Clinicoassistnzial Molcular profiling of myloid noplasms for dvloping innovativ prcision mdicin stratgis SAN MATTEO Clinicoassistnzial Idntification of nw molcular CASA SOLLIEVO thraputic targts in Mdullary thyroid SOFFERENZA cancr using nxt gnration squncingbasd approachs Biomdica Analysis of EMT lik bhaviour of hmatopoitic clls xprssing th lukmognic fusion protin AML1/ETO. I.E.O. Biomdica Oncology 1 Basic Translational Validation of pharmacogntic nhancmnt of Ras ERK signalling to prvnt nurodgnration and cognitiv dficits in mous modls of Parkinson's Disas. SAN RAFFAELE MILANO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Pagina 156 di 228

157 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt of a biotch systm for natural compound production, by plant in vitro tissucultur, for th prvntion and tratmnt of human dismtabolic disass. Istituto Suprior di Sanita' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs UltraSound, Contrast Enhancd UltraSound (CEUS) and 5 aminolvulinic acid (5 ALA) in tumour dtction at th bordr of high grad gliomas: A prospctiv study basd on a histopathological assssmnt. CARLO BESTA Clinicoassistnzial Long trm prognosis and mortality fiftn aftr acut coronary syndrom: th ABC* study on acut coronary syndrom (*ABC is acronym for Adria, Bassano, Congliano, and Padova Hospitals): malignancis, strok, gndr prognostic diffrnc. Vnto Clinicoassistnzial Population Scincs and Epidmiology Th possibl influnc of fat solubl vitamins on cognition and brain structural intgrity in patints with Scondary Progrssiv Multipl Sclrosis: a longitudinal study. SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Exploitation of ctdna (liquid biopsy) for thraputic dcision in mcrc Istituto Oncologico Candiolo Biomdica Th contribution of gntic and mtabolic factors to drug rsistanc in pdiatric nphrotic syndrom. MAGGIORE Clinicoassistnzial Digstiv, Kidny and Urological Systms Pagina 157 di 228

158 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Insid th mchanism of immun disrgulation du to EBV infction in MS SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Th rol of vitamin D and B status on cllular aging and ag rlatd disass Provincia autonoma Bolzano Clinicoassistnzial Biology of Dvlopmnt and Aging GENE ENVIRONMENT INTERACTIONS IN SARCOIDOSIS. ROLE OF ENVIRONMENTAL INFLUENCES ON SARCOIDOSIS SUSCEPTIBILITY GENES Emilia Romagna Biomdica Cardiovascular and Rspiratory Scincs Improvmnt of gliomas diagnosis and tratmnt: gnomic altration, imaging charactristic and circulating mirna studis REGINA ELENA Clinicoassistnzial Microbiom assssmnt in th myocardial tissu of patints with dilatd cardiomyopathy andmyocarditis ngativ to th known cardiotropic viruss. SPALLANZANI Biomdica Infctious Disass and Microbiology Q fvr in Italy: pilot study to invstigat prsnc, diffusion and gntic divrsity of Coxilla burntii IZSAM Biomdica Gns, Gnoms and Gntics Rol of non coding RNAs in ostosarcoma stmnss Toscana Biomdica Gns, Gnoms and Gntics Otoacoustic missions as biomarkrs of possibl synrgistic intraction in inducing haring damag: an xprimntal study INAIL Biomdica Population Scincs and Epidmiology Pagina 158 di 228

159 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not GENtic suscptibility, Thrombin gnration and whol blood viscolasticity assays: a nw intgrativ thranostic approach for hamostasis managmnt of PEdiatric patints with congnital disas (GENoTYPE) Toscana Clinicoassistnzial Cardiovascular and Rspiratory Scincs Innovativ tsting of bon substitut Istituto Suprior di Sanita' Biomdica bioavailability for oral surgry procdur. Musculoskltal, Oral and Skin Scincs Msnchimal stm cll drivd xtracllular vsicls as pharmacutical tool for th tratmnt and prvntion of pilpsy du to brain inflammation. OSPEDALE BAMBINO GESU' Biomdica Brain Disordrs and Nuroscinc Small Intstinal Bactrial Ovrgrowth (SIBO) syndrom in Multipl Sclrosis (MS) patints and strok survivors. Umbria Clinicoassistnzial Brain Disordrs and Nuroscinc Escluso dal Finanziamnto pr conflitto con critri bando:richista fondi al Ministro infrior a Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Gndr rlatd comparisons of lif habits, frtil lif charactristics and advancd MRI paramtrs in multipl sclrosis Sicilia Clinicoassistnzial Brain Disordrs and Nuroscinc Quality of lif in prsons with svr traumatic brain injury and thir cargivrs SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 159 di 228

160 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not DNA global dmthylation and spcific somatic mutation pattrns as potntial biomarkrs of risk for colorctal noplasm. Istituto Oncologico Candiolo Biomdica A NANOMEDICINE APPROACH FOR TRIPLE NEGATIVE BREAST CANCER (TNBC). TARGETING THROUGH INNOVATIVE NANOPARTICLE APTAMER BIOCONJUGATES. Toscana Biomdica Idntification of arly and prdictiv markrs of individual risk for had and nck cancr Toscana Biomdica Oncology 1 Basic Translational Exploring th suscptibility to fracturs in youth for its prvntion in adulthood: a phnotypic, functional and gnomic charactrization of bon fragility in childrn and adolscnts and thir familis. SAN RAFFAELE MILANO Biomdica Gns, Gnoms and Gntics 19, Improving Diagnostic and Thraputic C.R.O. AVIANO Pathway in Ovarian Cancr: taking advantag of a spcializd rfrral cntr. Clinicoassistnzial Halthcar Dlivry and Mthodologis 19, Immigrants and sanitation: an accurat diagnosis to assss th sprad of parasitic infctions and th associatd immun modulation Campania Biomdica Infctious Disass and Microbiology 19, GENDER RELATED INSIGHT INTO CARDIOVASCULAR RISK: A SYSTEM MEDICINE APPROACH Toscana Biomdica Risk, Prvntion and Halth Bhavior 19, Pagina 160 di 228

161 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Nw tchnolgis in th diagnosis and survillanc of invasiv bactrial infctions in Italy:an ssntial tool in th planning and monitoring of prvntion stratgis Toscana Clinicoassistnzial Infctious Disass and Microbiology 19, Dvlopmnt and production of a novl dcllularizd drmal matrix for rconstructiv surgry procdurs. Pimont Biomdica Bionginring Scincs and Tchnologis 19, Epilptic sizurs prdiction through nonlinar dynamic analysis of EEG signals Sardgna Biomdica Brain Disordrs and Nuroscinc 19, HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? IZSPLV Biomdica Vtrinary 19, Cockayn syndrom: targting mitochondrial dysfunction as a novl thraputic approach to prvnt nurodgnration Istituto Suprior di Sanita' Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 19, Usfulnss of non invasiv tst Gastropanl in ordr to improv th Protonic Pomp Inhibitors (PPIs) administration appropriatnss in ldrly population in Parma ara. Emilia Romagna Clinicoassistnzial Digstiv, Kidny and Urological Systms 19, Complmntary vaccination with dndritic clls pulsd with autologous tumor lysat in rsctd stag III and IV mlanoma patints: a phas II randomizd trial Istituto Scintifico Romagnolo Biomdica 19, Pagina 161 di 228

162 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rol of xosoms on immun rspons inflammatory/rgulatory balanc during chronic HCV and HBV infctions SPALLANZANI Biomdica Immunology 19, Innat immun rsponss in Multipl Sclrosis SANTA LUCIA Biomdica Immunology 19, High dnsity of tumor associatd macrophags (TAM) prdicts th rsponsivnss of stag III colorctal cancr (CRC) to adjuvant chmothrapy. HUMANITAS Clinicoassistnzial 19, CARDIOVASCULAR SCREENING OF LONG TERM CANCER SURVIVORS AFTER CHEST RADIATION THERAPY. C.R.O. AVIANO Clinicoassistnzial Cardiovascular and Rspiratory Scincs 19, Off labl us of sildnafil in nwborn and infants with pulmonary hyprtnsion: pharmacogntic/ pharmacokintic analysis and possibl influnc on cognitiv functions OSPEDALE BAMBINO GESU' Clinicoassistnzial Cardiovascular and Rspiratory Scincs 19, Nw biomarkrs to prdict prognosis and tailor systmic thrapy in patints with Psudomyxoma Pritoni ISTITUTO TUMORI MILANO Clinicoassistnzial 19, SAFETY AND EFFICACY OF PHYTOSOMIAL CURCUMIN IN NON ALCOHOLIC FATTY LIVER DISEASE: A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL. Pimont Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 19, Pagina 162 di 228

163 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Gntic Assssmnt of Rproductiv Activity in BUffalo and CAttl IZSME Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 19, Mutational analysis of Hdghog signaling pathway gns in basal cll carcinomas from tacrolimus/cyclosporin tratd rnal transplant rcipints Pimont Biomdica 19, Epidmiology of Tinnitus in Italy using a Comprhnsiv Approach (ETICA) MARIO NEGRI Clinicoassistnzial Population Scincs and Epidmiology 19, Gnotyp/phnotyp corrlation in rtinitis pigmntosa: us of multipl animal modls of photorcptors dgnration to lucidat molcular mchanisms of disas and rspons to diffrnt thrapis Lazio Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 19, Calcinurin inhibitors (CNIs) monitoring in priphral blood mononuclar clls (PBMCs) in th clinical car of d novo hart transplantd patints Pimont Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training 19, Pyrimthamin drivativs: a nw class of "low cost" antifolat drugs for tratmnt of mtastatic mlanoma. A prclinical study. Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational 19, Pagina 163 di 228

164 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Nw molcular dp squncing approach for minimal rsidual disas dtction in adult Acut Lymphoblastic Lukmia patints for risk stratification and tratmnt dfinition. Lombardia Clinicoassistnzial 19, Dvlopmnt of nw biomarkrs to stratify th PML risk in multipl sclrosis patints during Natalizumab thrapy: study of th potntial corrlation btwn prsnc of human Polyomavirus JC DNA in blood/urin sampls and cytokin chmokin profiling in p Lazio Clinicoassistnzial Infctious Disass and Microbiology 19, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Advancd in vitro fficacy prdictivo tools for prsonalizd dsign of immun chckpoint blockad immunothrapy Lazio Biomdica 19, Nw insights in th diagnosis and managmnt of patints with mitochondrial disordrs in th viw a nw thraputic ra: natural history, biomarkrs, outcom masurs and quality of lif Sicilia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 19, Rlationship btwn cognitiv function, typ 1 and typ 2 diabts Friuli Vnzia Giulia Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc 19, Addrssing th rol of RPF 1 dvlopmntal factor in th pigntic landscap of Wilms tumor and Nuroblastoma pdiatric cancrs ISTITUTO TUMORI MILANO Biomdica Oncology 1 Basic Translational 19, Pagina 164 di 228

165 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A nw stratgy against nurodgnration: pharmacological modulation of th Ca2+ prmability of ionotropic glutamat rcptors NEUROMED Biomdica Brain Disordrs and Nuroscinc 19, Antnatal human hart dvlopmnt Lombardia Clinicoassistnzial Cardiovascular and Rspiratory Scincs 19, Tumor charactristics and snsitivity to diffrnt tratmnts in human pancratic adnocarcinoma : towards an individualizd thrapy of cancr Lombardia Biomdica 19, Dsign of rational and innovativ immunogns basd on HIV 1 clad C Env protins spcifically mutatd in slctd consrvd glycans for broadly ffctiv vaccin purpos Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch 19, Idntification of novl gns involvd in inhritd nphropathis causing ndstag rnal disas at a young ag through whol xom squncing and copy numbr analysis. Pimont Clinicoassistnzial Digstiv, Kidny and Urological Systms 19, Non invasiv brain stimulation in rhabilitation of nurological and cognitiv dfcts in post strok patints. Sicilia Clinicoassistnzial Brain Disordrs and Nuroscinc 19, Immun rsponss of man and animals to infctious and non infctious strssors: idntification of cross spcis host paramtrs of immunocomptnc IZSLER Biomdica Immunology 19, Pagina 165 di 228

166 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A translational study of dysautonomia and othr non motor symptoms in parkinsonism NEUROMED Biomdica Brain Disordrs and Nuroscinc 19, THE MEVALONATE PATHWAY AND CXCR4 SIGNALING CROSS TALK IN CHRONIC LYMPHOCYTIC LEUKEMIA: A TARGET TO OVERCOME FLUDARABINE RESISTANCE? Pimont Biomdica Oncology 1 Basic Translational 19, Explor, Idntify and Validat prdictiv/prognostic biomarkrs for Diabtic Macular Edma: an onsit analysis. BIETTI Biomdica Cll Biology 19, IMPLEMENTATION OF LIVER CIRRHOSIS DIAGNOSIS AND DEVELOPMENT OF A TELEMEDICINE PROJECT FOR TERRITORIAL MANAGEMENT Vnto Clinicoassistnzial Digstiv, Kidny and Urological Systms 19, Biosafty in shllfish farming: study of mrging zoonoss and application of an intgratd modl for biological risk managmnt in livstock production, food scurity and nvironmntal assssmnt in supply chains IZSSA Biomdica Vtrinary 19, ß D GLUCAN DRIVEN EARLY DE ESCALATION OF ANTIFUNGAL THERAPY IN CRITICALLY ILL PATIENTS: AN INNOVATIVE ANTIFUNGAL STEWARDSHIP PROGRAM Emilia Romagna Clinicoassistnzial Infctious Disass and Microbiology 19, Pagina 166 di 228

167 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A PHASE II STUDY OF AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE. Emilia Romagna Clinicoassistnzial Digstiv, Kidny and Urological Systms 19, Exposur to chmicals, psticids and substancs of abus in prgnant womn: valuation of DNA damag and oxidativ strss paramtrs in priphral lymphocyts as biomarkrs of rproductiv risk Toscana Biomdica Risk, Prvntion and Halth Bhavior 19, Disscting th molcular ntwork of intrlukin 1ß in non alcoholic statohpatitis in ordr to idntify novl potntial thraputic targts OSPEDALE BAMBINO GESU' Biomdica Digstiv, Kidny and Urological Systms 19, Lvls of mirna from srum xosoms as potntial prdictiv biomarkrs of clinical outcom in pancratic ductal carcinoma patints ONCOLOGICO DI BARI Biomdica 19, Sustainability and quality of car: th rol of ffctiv multi dimnsional and multi lvl PRfOrmanc managmnt systm (PMS) in halthcare organizations (PROCARE) Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis Studio multicntrico ossrvazional sull'pidmiologia l'outcom dll'arrsto cardiaco in Italia. Efftti dll'implmntazion di una rilvazion sistmatica sull'sito. Emilia Romagna Biomdica Halthcar Dlivry and Mthodologis Pagina 167 di 228

168 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Halth and halthcar for ldrly immigrants and minoritis in an italian ara with high immigration and aging indx: an intgratd approach basd on cultural comptncy and thnogriatric prsonalizd car Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis Implmntation and sustainability of a systms mdicin approach in patints affctd by cardiovascular disas and dysmtabolic status. Toscana Clinicoassistnzial Cardiovascular and Rspiratory Scincs Blood Managmnt Program in cancr surgry ARCISPEDALE Clinicoassistnzial Halthcar Dlivry and Mthodologis Us of mropnm in critically ill patints with gram ngativ infctions. A multicntr randomizd study. SAN RAFFAELE MILANO Clinicoassistnzial Infctious Disass and Microbiology Study on micrornas as arly prdictors Emilia Romagna of contrast inducd nphropathy in patints with acut myocardial infarction tratd with prcutanous coronary intrvntion. Clinicoassistnzial Cardiovascular and Rspiratory Scincs Ethical Counsling Srvic I.E.O. Clinicoassistnzial Halthcar Dlivry and Mthodologis Validation of a nw Low Cost Point of Car systm for bilirubin dtrmination in nwborns Impact on hyprbilirubinmia prvntion and cost rduction for th National Halth Systm (SSN) BURLO GAROFALO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 168 di 228

169 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Constitution of an infrastructur for advancd srvics in Public Halth Istituto Suprior di Sanita' Biomdica Halthcar Dlivry and Mthodologis Evidnc of a thraputic rol of NGF in multipl sclrosis: clinical and xprimntal studis. BIETTI Clinicoassistnzial Brain Disordrs and Nuroscinc PROSPECTIVE MULTICENTER STUDY ON RESEARCH AND VALIDATION OF PREDICTIVE BIOMARKERS OF RESPONSE TO AZACITIDINE IN PATIENTS WITH HIGH RISK MYELODYSPLASTIC SYNDROMES. Emilia Romagna Biomdica A Multidisciplinary Magntic Rsonanc Imaging and Immunohistochmical study of human ftal malformation of cortical dvlopmnt. CARLO BESTA Biomdica Brain Disordrs and Nuroscinc Cardiac and Vascular strss cho during normobaric hypoxia in coronary hart disas patints and halthy subjcts: A nw non invasiv, low cost tst to improv safty of rcrational mountain climbrs and workrs at high altitud. Vall d'aosta Clinicoassistnzial Cardiovascular and Rspiratory Scincs Extracllular microrna in bronchoalvolar lavag for arly dtction of lung cancr IRCCS AOU San Martino IST (Gnova) Biomdica Pagina 169 di 228

170 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Effct of adaptd physical activity (APA) training programs on xrcis tolranc, cardio pulmonary functionality, muscl strngth, symptoms, inflammatory cytokins rspons, quality of lif in subjcts affctd by multipl sclrosis (MS). SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc Cardiovascular disass and impact of comorbid rspiratory disass (CADICORD) Umbria Clinicoassistnzial Cardiovascular and Rspiratory Scincs Nar road xposur and halth ffcts of Ultrafin Particls INAIL Biomdica Population Scincs and Epidmiology Novl nanotchnology basd stratgis for diagnostic, thraputic and and clinical car in lymphoma. Toscana Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training Thyroid dysfunction and chmical compound xposur in th tiology of Attntion Dficit/Hypractivity Disordr (ADHD) Istituto Suprior di Sanita' Clinicoassistnzial Brain Disordrs and Nuroscinc Dvlopmnt of aptamrs as novl diagnostic and thraputic tools for Diabts Mllitus HUMANITAS Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Lycopn, Slnium and Polydoxyribonuclotid: a tripl thraputic approach in conditions of mal infrtility Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Pagina 170 di 228

171 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Familial brast and mlanoma disass: common and diffrnt gntic and pigntic faturs ONCOLOGICO DI BARI Biomdica Comparativ approachs to th molcular immunopathognsis of Paratubrcolosis IZSLER Biomdica Vtrinary Intgratd/tird approach as a tool for valuating potntial toxicity of nanomatrials of concrn for human halth. Idntification of rlvant biomarkrs for immun, rproductiv, ndocrin and gno toxicity Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis TROPHIC ACTIVITY OF SPERMIDINE SUPRAMOLECULAR COMPLEXES IN OSTEOARTHRITIS RIZZOLI Biomdica Musculoskltal, Oral and Skin Scincs Inactivation of th tumor supprssor IRF 1 by th IkappaB kinas (IKK) psilon in brast cancr: idntification of druggabl targts through protomic analysis Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Multidrug Rsistanc of th Blood Brain Barrir: clinical implications and pharmacological activity of anticancr agnts Toscana Biomdica Human adipos msnchymal stm clls trasplantation in dgnrativ disc disas: in vitro and invivo study of th molcular mchanism involvd in immunomodulation and cll rcovry. CARLO BESTA Biomdica Bionginring Scincs and Tchnologis Pagina 171 di 228

172 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dvlopmnt of synthsis tools for orthopadic surgry using biomatrials basd on custom mad 3D printing tchnology Toscana Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Natural y drops from allognic umbilical cord blood plasma Istituto Suprior di Sanita' Biomdica Halthcar Dlivry and Mthodologis Approach to patints with shock du to systmic capillary lak syndrom (Clarkson Disas) admittd to mrgncy dpartmnts of Rgion Lombardia and idntification of th mchanisms lading to th incras in ndothlial prmability rsponsibl for th Lombardia Biomdica Cardiovascular and Rspiratory Scincs DATA MINING IN CLINICAL TRIALS: INVESTIGATING SYMPTOM NETWORKS TO IMPROVE THERAPEUTIC STRATEGIES FOR MAJOR DEPRESSION Istituto Suprior di Sanita' Biomdica Biobhavioral and Bhavioral Procsss Physiothrapy and Ostoporosis: Idntification of clinical and biological markrs for th optimisation of th individualizd approach to rhabilitation Programs Sicilia Biomdica Musculoskltal, Oral and Skin Scincs SEARCHING NEW DIAGNOSTIC/PROGNOSTIC MARKERS OF CANDIDEMIA Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology Pagina 172 di 228

173 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prclinical and clinical study on Schizophrnia Bipolar Disordr Spctrum (SZ BPDs) and Frontotmporal Dmntia (FTD) shard gntic and nurobiological profil Vnto Biomdica Brain Disordrs and Nuroscinc Non mlanoma skin cancrs and inflammation: Rols of NF kb rgulatd Gadd45b gn Abruzzo Biomdica Oncology 1 Basic Translational Halth rlatd quality of lif in childrn with Nurofibromatosis 1: a nation wid survy projct on dtrmining factors CARLO BESTA Clinicoassistnzial Halthcar Dlivry and Mthodologis Idntification of causativ gn(s) for rar ntric nuropathis by nxt gnration squncing and functional studis in zbrafish GASLINI Biomdica Gns, Gnoms and Gntics Unravling th molcular basis of icosapntanoic acid (EPA) ffcts on nural dvlopmnt and nurodgnration Istituto Suprior di Sanita' Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc Mtallothionins as prdictiv biomarkrs for cardiovascular vnts in patints with svr carotid or priphral athrosclrosis I.N.R.C.A. Biomdica Vascular and Hmatology Systms data for individual rnal cancr mdicin ISTITUTO TUMORI MILANO Clinicoassistnzial Nw mthodologis for oncologic diagnostic in thyroid cancr Toscana Biomdica Pagina 173 di 228

174 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Projct Titl: Birth outcoms in womn with cancr: a population basd cohort study ISTITUTO TUMORI MILANO Clinicoassistnzial Population Scincs and Epidmiology Rol of Mycobactrium avium subspcis paratubrculosis (Map) as a triggr in Typ 1 Diabts, Hashimoto Thyroiditis and Multipl Sclrosis Sardgna Biomdica Infctious Disass and Microbiology Radiation Inducd abscopal/bystandr Effcts (RIBEs) upon Strotactic Body RadioThrapy (SBRT) in oligomtastatic patints: idntification of th molcular/cllular playrs involvd REGINA ELENA Clinicoassistnzial Sr/Thr protin phosphatass as potntially druggabl biomarkrs to prdict trastuzumab thraputic rsponsivnss, and countract th dvlopmnt of rsistanc in brast cancr SAN RAFFAELE MILANO Biomdica Oncology 1 Basic Translational 20, Dtrminants of halthy aging in th EPIC Italy cohort ISTITUTO TUMORI MILANO Clinicoassistnzial Risk, Prvntion and Halth Bhavior 20, Kynurnin Pathway Mtabolits and Suicid risk; a potntial biomarkr for suicid prvntion Lazio Clinicoassistnzial Risk, Prvntion and Halth Bhavior 20, Nw Biomolcular tools for Murin Typhus Diagnosis Calabria Biomdica Infctious Disass and Microbiology 20, Pagina 174 di 228

175 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Biomchanical charactrization of Carotid Plaqu by innovativ ultrasound in strok(biocap): Validation Against Magntic Rsonanc Imaging and Immunoistochmistry of Radiofrquncy Basd Mthods Intgrating 3D Imaging and Flow Vlocity Distribution, and Toscana Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 20, Halthy Math S.CAMILLO Clinicoassistnzial Biobhavioral and Bhavioral Procsss 20, IMPROVEMENT OF PET 2 PROGNOSTIC IMPACT FOR A TAILORED THERAPY FOR HODGKIN LYMPHOMA Sicilia Biomdica 20, Lifstyls, risk factors, and mrging biomarkrs for th prdiction of chronic non communicabl disass in th gnral adult population Istituto Suprior di Sanita' Clinicoassistnzial Risk, Prvntion and Halth Bhavior 20, Panallrgns in Pdiatrics: volution of th molcular allrgnic profil in childrn with pollinosis Emilia Romagna Biomdica Population Scincs and Epidmiology 20, From lifstyl to mitochondrial bnfits: study on a combind thraputic approach tohuntington's disas Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc 20, Effcts of Nuropptid Y on th cntral nrvous systm nurons of rat modls of Alzhimr Disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 20, Pagina 175 di 228

176 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Immunologic biomarkrs for clinical and thraputic managmnt of Autoimmun disass SAN GALLICANO Biomdica Immunology 20, Mtastatic potntial of CD44v6 + circulating tumor clls in gastrointstinal malignancis CROB Clinicoassistnzial 20, High risk pigntic biomarkrs in th onst of malignant plural msothlioma in asbstos xposd subjcts ONCOLOGICO DI BARI Biomdica 20, Idntification of a biological ntwork as potntial usful tool for monitoring, prvnting and dvloping prsonalisd tratmnts for sporadic thoracic aortic anurysm Sicilia Biomdica Vascular and Hmatology 20, Idntification of indpndnt biomarkrs prdicting aortic dissctions in patints with Marfan syndrom. AUXOLOGICO Clinicoassistnzial Cardiovascular and Rspiratory Scincs 20, Rol of ApoL1 in th Pathognsis of HIV Associatd Nphropathy HUMANITAS Biomdica AIDS and Rlatd Rsarch 20, Idntification of human gns involvd in th pathognsis of kratoconus Vnto Biomdica Brain Disordrs and Nuroscinc 20, PROJECT RANDOM: AXILLARY DISSECTION OR NOT IN SENTINEL NODE MACROMETASTASIS OF BREAST CANCER HUMANITAS Clinicoassistnzial 20, Pagina 176 di 228

177 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Bta actin oxidation: a nw prdictiv biophysical biochmical markr for autism Toscana Biomdica Biological Chmistry and Macromolcular Biophysics 20, Innovativ thrapy for prcancrous skin lsions : improving fficacy and incrasing patint complianc, whil rducing sid ffcts Emilia Romagna Biomdica 20, Slf Expandabl Mtal Stnts As Bridg To Surgry Tratmnt For Acut Malignant Colonic Obstruction Sicilia Clinicoassistnzial Digstiv, Kidny and Urological Systms 20, MOTOR REHABILITATION IN SPINAL CORD INJURY: ENHANCING RECOVERY THROUGH COGNITION. Lombardia Clinicoassistnzial Brain Disordrs and Nuroscinc 20, For patints' sak: how rsarch Emilia Romagna translats into practic. A study on th impact of publicly fundd halth rsarch Clinicoassistnzial Halthcar Dlivry and Mthodologis 20, Pharmacogntic study on Busulfan and hpatic vno occlusiv disas in padiatric patints undrgoing hmatopoitic stm cll transplantation BURLO GAROFALO Clinicoassistnzial 20, Pntraxin 3: a novl biomarkr for diagnosing prostat cancr. A validation study. Puglia Biomdica 20, Psudoviral Immunity and Podocyt strss protins in Lupus Erithmatosus. From 'in vivo' rsarch on autoantibodis to mchanisms GASLINI Biomdica Digstiv, Kidny and Urological Systms 20, Pagina 177 di 228

178 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not PREDICTION OF HIGH GRADE GLIOMAS GENOMIC SUBTYPES BY MEANS OF ADVANCED MAGNETIC RESONANCE IMAGING BIOMARKERS CASA SOLLIEVO SOFFERENZA Biomdica 20, Digging dpr into molcular mchanisms of bcl 2 mdiatd rgulation of diffrnt functions in mlanoma REGINA ELENA Biomdica Oncology 1 Basic Translational 20, Improving clinical car, optimizing th rsarch ntwork for nurological patints: a Novl ORganizational MAtrix (NORMA). CARLO BESTA Clinicoassistnzial Halthcar Dlivry and Mthodologis 20, Diffrnt NHERF1 subcllular localizations in brast cancr: could gntic and posttranslational altrations shd light on its us in clinical practic? ONCOLOGICO DI BARI Biomdica Oncology 1 Basic Translational 20, Evaluation of two diffrnt postpartum and post abortion rublla vaccination protocols in a sampl of Italian hospitals. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 20, A pilot study of prthraputic sorafnib valuation in primary clls, and in tumor xnografts, in papillary aggrssiv thyroid cancr. Toscana Biomdica 20, Brain Dvlopmnt in Childrn Born Prtrm: an fmri, Psychological and Nurological Follow up at Scholar Ag SAN RAFFAELE MILANO Clinicoassistnzial Brain Disordrs and Nuroscinc 20, Pagina 178 di 228

179 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not PREDICTIVE SERUM EPIGENETICS IN HEAD AND NECK CANCER Pimont Biomdica 20, Dcoding th transcriptom of circulating msnchymal stm clls in patints with skltal disass and obsity. Vnto Biomdica Gns, Gnoms and Gntics 20, Nonatal cardioplgia projct (NECAP): invstigations on protction of ischmic immatur harts. Emilia Romagna Biomdica Cardiovascular and Rspiratory Scincs 20, Early dtction and prvntion of subtl cognitiv dclin: nuropsychological and imaging signatur of asymptomatic at risk adults SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 20, Comparing ffctivnss and costffctivnss of social car halth car trajctoris xprincd by frail oldr popl in ral lif Lombardia Clinicoassistnzial Population Scincs and Epidmiology 20, IDENTIFICATION OF NEW STRATEGIES TO IMPROVE THE OUTCOME OF TRAUMATICBRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEWTARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Sicilia Biomdica Brain Disordrs and Nuroscinc 20, Protin and microrna xprssion profils of multipl sclrosis patints in glatiramr actat tratmnt: potntial biomarkrs Puglia Biomdica Emrging Tchnologis and Training in Nuroscincs 20, Pagina 179 di 228

180 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Improving chronic pain tratmnt using nw formulatd topical nanomdicins. Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis 20, An addrssd nutrigntic approach to calcium nphrolithiasis SAN RAFFAELE MILANO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 20, An intgratd gnomic and protomic approach for cancr scrning and targtd thrapy in arly stag lung adnocarcinoma Abruzzo Biomdica Association btwn intstinal microbiom and cardiornal syndrom in chronic hart failur patints Puglia Clinicoassistnzial Cardiovascular and Rspiratory Scincs Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Blood brain barrir prmability in ALS from in vitro to in vivo AUXOLOGICO Biomdica Brain Disordrs and Nuroscinc Hippocampal msolimbic ntwork dysfunction: a vicious worsning loop of cognitiv dclin in Alzhimr's disas? A molcular, lctrophysiological and bhavioral invstigation on a murin modl SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc Pagina 180 di 228

181 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not USING VIRTUAL REALITY AND ROBOTICS REHABILITATION INTERVENTION TO IMPROVE SOCIAL AND COGNITIVE ABILITY IN ADOLESCENTS AND CHILDREN WITH AUTISM Abruzzo Clinicoassistnzial Brain Disordrs and Nuroscinc Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto A DCE MRI quantitativ indx for prdiction and arly assssmnt of rspons to no adjuvant radiochmothrapy in locally advancd rctal cancr (LARC) PASCALE Clinicoassistnzial PAIN ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH SUCCESSIVE NEURODEVELOPMENTAL INJURIES BURLO GAROFALO Clinicoassistnzial Brain Disordrs and Nuroscinc Evaluation of patint prfrncs around th diffrnt cancr srvics dimnsions: nwvidncs for improving srvic organisation. Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis Coming full circl on prnatal noninvasiv gntic tsts: from halth tchnology assssmnt, through rcommndations for clinical practic/rsarch, to support for dcisions on covrag Emilia Romagna Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Rprogramming and stmnss in ovarian cancr: function, signaturs and clinical rlvanc I.E.O. Biomdica Oncology 1 Basic Translational Pagina 181 di 228

182 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Validation of PTEN as diagnostic, prognostic and thraputic prdictiv bio markr in colorctal cancr and idntification of nw thraputic targts. Campania Biomdica Oncology 1 Basic Translational Rol of autophagy in growth, progrssion and ndothlial transdiffrntiation of nuroblastoma clls GASLINI Biomdica Oncology 1 Basic Translational ROLE OF TUMOR MICROENVIRONMENT IN IMMUNE MODULATION Toscana Biomdica Oncology 1 Basic Translational REDOX REGULATION OF MUTYH DNA GLYCOSYLASE ACTIVITY VIA ITS IRON SULFUR CLUSTER AND ROLE IN INFLAMMATION Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Optimizing managmnt of svr infctions du to drug rsistant gramngativ bactria in hospitalisd patints Campania Clinicoassistnzial Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Comprhnsiv gntic analysis in Parkinson Disas. Campania Biomdica Gns, Gnoms and Gntics Dtction of DNA mutations in urin of patints with prostat cancr for th idntification of arly prognostic biomarkrs Emilia Romagna Biomdica Oncology 1 Basic Translational Pagina 182 di 228

183 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Charactrization of ipsc drivd nurons from individuals with Autism Spctrum Disordrs: an in vitro modl for prclinical drug scrning Toscana Biomdica Brain Disordrs and Nuroscinc Rol of GALNT2 on insulin rsistanc and glucos homostasis CASA SOLLIEVO SOFFERENZA Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Early Onlin Rhabilitation of Dvlopmntal Dyslxia: a randomizd clinical study BURLO GAROFALO Clinicoassistnzial Brain Disordrs and Nuroscinc E cadhrin and signalling pathway componnts for using in clinic as diagnostic and prognosticvalu in gastric carcinoma C.R.O. AVIANO Biomdica RELATIONSHIP BETWEEN OBESITY, DIABETES MELLITUS, DYSLIPIDEMIA AND CARDIOVASCULAR DISEASES Toscana Clinicoassistnzial Cardiovascular and Rspiratory Scincs Outcoms and cost of car in diabtic subjcts ovr 70 yars old living in Rgion March (Italy): rsults from a rcord linkag analysis of administrativ and clinical data btwn 2008 and 2012 I.N.R.C.A. Clinicoassistnzial Halthcar Dlivry and Mthodologis Extracllular matrix (ECM): nw stratgis for diagnostic, thraputic and clinical car in Oncology Vnto Biomdica Validation of th prdictiv rol of LH Rcptor xprssion for ndomtrial cancr patints stratification. Toscana Clinicoassistnzial Pagina 183 di 228

184 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Anglman Syndrom: a clinicalnurophysiological, functional imaging and biochmical invstigation to uncovr nw thraputic stratgis MEDEA Biomdica Brain Disordrs and Nuroscinc Impact of gndr and of rproductiv status on livr damag and cardiovascular dysfunction in patints with Nonalcoholic Fatty Livr Disas Pimont Clinicoassistnzial Digstiv, Kidny and Urological Systms Mtabolomic profil of th amniotic fluid collctd during amniocntsis in th scond trimstr of gstation: prdictability for rnal and rspiratory disass in infancy Vnto Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Unicllular ukaryots as biomarkrs of intstinal dysbiosis in patints with Irritabl Bowl Syndrom (Diarrhoa prvalnt, IBS D) and Functional Diarrhoa Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology A molcularly basd diagnostic and pharmacological approach to IgA nphropathy Lazio Biomdica Immunology Rducing ovrwight and obsity in patints as a stratgy to improv disas activity and svrity and to rduc th nd for biological drugs in chronic inflammatory rhumatic disass. Lazio Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Pagina 184 di 228

185 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Study of nw biomarkrs for diagnoss of disordrs of bil acid synthsis by mass spctromtry and mtabolomics approach. Vnto Biomdica Digstiv, Kidny and Urological Systms Idntification of arly markrs of Panic Disordr: a gn by nviromnt invstigation in a dvlopmntal framwork. SAN RAFFAELE MILANO Biomdica Brain Disordrs and Nuroscinc Prdicting chmothrapy toxicity in th ldrly: a prformanc assssmnt of xisting tools vs. aging biomarkrs in th Ligurian population Liguria Biomdica How is it possibl to dfin rhabilitation car appropriatnss? Th impact of an altrnativ valuation systm on th appropriatnss of halth car rsourcs Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis 21, W Nd TYME: th Italian "hub and spok" ntwork for cntralizd clinical and translational rsarch to nsur multidisciplinary xprtis and to promot drug dvlopmnt and biomarkr discovry for ThYmic MalignanciEs ISTITUTO TUMORI MILANO Clinicoassistnzial 21, Molcular mchanisms mdiating mtastasis in rnal angiomyolipoma and lymphangioliomyomatosis formation: possibl clus for idntification of nw pharmacological tratmnts Pimont Biomdica Digstiv, Kidny and Urological Systms 21, Pagina 185 di 228

186 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ktognic dit in th tratmnt of child drug rsistant pilpsis: a longitudinal multicntr study on mtabolic factors and pigntic prdictors of fficacy and tolrability MONDINO Clinicoassistnzial Brain Disordrs and Nuroscinc 21, Altrations of gut barrir and lipid mtabolism in subjcts with livr statosis: novl insights into molcular targts and intrvntions using prbiotics DE BELLIS Biomdica Risk, Prvntion and Halth Bhavior 21, Circulating microrna signaturs for glioblastoma multiform Vnto Biomdica 21, Targtd Nxt gnration squncing: implmntation of a novl diagnostic tool in th clinical routin of nwborn scrning Emilia Romagna Biomdica Gns, Gnoms and Gntics 21, Efficacy and safty of an innovativ hrbal tratmnt on an ancint disas: th coxarthrosis Toscana Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 21, EVALUATING AND RANKING PATIENT ORIENTED OUTCOME MEASURES IN BRAIN TUMOR PATIENTS WITH EVIDENCE BASED CRITERIA Vnto Clinicoassistnzial 21, Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro infrior a Gnom wid Association study to valuat gntic risk factors for SPlanchnic vnousthrombosis (GASP Study) MAGGIORE Biomdica Vascular and Hmatology 21, Pagina 186 di 228

187 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Can w idntify th structural and gntic traits of bon impairing dismtabolisms? A pilot study in Ostognsis Imprfcta and Klinfltr Syndrom patints. RIZZOLI Biomdica Musculoskltal, Oral and Skin Scincs 21, Undrstanding th intraction btwn inflammatory factors profil in strok patints to dsign a tailord thraputic approach MONDINO Biomdica Brain Disordrs and Nuroscinc 21, From migrain to Mdication Ovrus: nvironmntal, clinical and molcular risk stratification for prdicting migrain progrssion and for planning of prvntion stratgis. Istituto Scinz Nurologich Biomdica Brain Disordrs and Nuroscinc 21, Vascular complications in patints with chronic myloid lukmia: valuation of possibl advrs ffcts of nilotinib on ndothlial function. IRCCS AOU San Martino IST (Gnova) Biomdica 21, Nonicotinoids and pyrthroids, an mrging halth issu for bs and humans IZSAM Biomdica Vtrinary 21, Hart rmodlling and xrcis tolranc in chronic obstructiv pulmonary disas rlatd to diffrnt phnotyps of th disas Emilia Romagna Biomdica Cardiovascular and Rspiratory Scincs 21, Diagnostic validation of circulating micrornas as novl NSTEMI biomarkrs in old and vry old patints. I.N.R.C.A. Clinicoassistnzial Cardiovascular and Rspiratory Scincs 21, Pagina 187 di 228

188 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rol of gut microbioma and circulatingrna in cliac patints Lombardia Biomdica Digstiv, Kidny and Urological Systms 21, A multidisciplinary approach to optimiz th clinical managmnt of patints and mak it rady to th nw diagnostic and thraputic opportunitis. Th cas of arrhythmognic inhritd disass. Pimont Clinicoassistnzial Cardiovascular and Rspiratory Scincs 21, Host rspons to hrps simplx virus 1 (HSV1) rcurrnt infctions and Alzhimr's disas: looking for pathogntic corrlations and thraputic vaccins. SAN RAFFAELE PISANA Biomdica Infctious Disass and Microbiology 21, Mutational profil of HCV non structural SAN RAFFAELE MILANO Biomdica Infctious Disass and rgions (NS3, NS5a and NS5b) associatd with dirct acting antivirals rsistanc in HIV/HCV coinfctd individuals naiv or non rspondr to dual (Pg intrfron plus ribavirin, P R) anti HCV tratmnt: possibl i Microbiology 21, Scond Primary Malignancis in Thyroid Cancr Survivors: Epidmiological Impact, Pathogntic Factors and Implications ARCISPEDALE Biomdica Population Scincs and Epidmiology 21, An Animal Bhavior Analysis Systm xploiting th passiv RFID Tchnology in UHF band Istituto Suprior di Sanita' Biomdica Biobhavioral and Bhavioral Procsss 21, Tissu nginrd gut as a novl modl to study th mchanisms of Crohn s disas intstinal fibrosis SAN MATTEO Biomdica Digstiv, Kidny and Urological Systms 21, Pagina 188 di 228

189 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prvalnc of infctions in prgnancy among immigrant compard to rsidnt mothrs: ffct of th inappropriatnss of prnatal car on th incidnc, svrity and long trm outcoms of congnital infctions in ach group's babis. OSPEDALE BAMBINO GESU' Clinicoassistnzial Infctious Disass and Microbiology 21, Sodium calcium xchangr (NCX): a nw playr in nuronal dgnration occurring in Parkinson's Disas SDN Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 21, Proprativ computr assistd planning and intraoprativ navigation in complx surgry of musculoskltal tumors RIZZOLI Clinicoassistnzial 21, A randomizd controlld clinical trial to assss th rol of msalazin as a modulator of gut microbial translocation and systmic immun activation in chronically infctd, ART tratd HIV subjcts Istituto Suprior di Sanita' Clinicoassistnzial AIDS and Rlatd Rsarch 21, Impact on clinical car of th rorganization of tst for antiphospholipid antibodis in laboratory analysis. Friuli Vnzia Giulia Clinicoassistnzial Vascular and Hmatology 21, Implmntation and improvmnt of a prdicting modl of all caus mortality in patints with typ 2 diabts mllitus living in Apulia, Southrn Italy. CASA SOLLIEVO SOFFERENZA Clinicoassistnzial Population Scincs and Epidmiology 21, Pagina 189 di 228

190 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Dp squncing and functional analysis of th mirnom in brast cancr progrssion: particular focus on xosoms, hypoxia and mir 328 Calabria Biomdica Oncology 1 Basic Translational 21, Sarch for pathognic mchanisms of haploinsufficincy of LETM1 and WHSC1 in Wolf Hirschhorn syndrom and thraputic trial with Vitamin C. Lazio Biomdica Biobhavioral and Bhavioral Procsss 21, Dvlopmnt and institution of a rar cancrs ntwork in th "Rgion Abruzzo" Abruzzo Clinicoassistnzial Population Scincs and Epidmiology Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro infrior a Analysis of human pididymis protin 4 in pithlial ovarian cancr: biological rol and prdictiv significanc Lombardia Biomdica Novl srum biomarkrs of livr disas progrssion in obs patints with livr statosis Sicilia Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Mild cognitiv impairmnt and progrssion to Alzhimr's disas: association with hrps viruss infctions. Emilia Romagna Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 190 di 228

191 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Global Rar Tumor Ntworking and nw staging/prognostic concpts in Thymic Epithlial Tumors and in Non Small Cll Lung Carcinomas mtastatic to th Mdiastinum: an intgratd clinicopathological and molcular study REGINA ELENA Clinicoassistnzial Enginrd nanoparticls: potntial rol in inducing bronchial hyprrsponsivnss in xposd workrs. SAN RAFFAELE PISANA Biomdica Bionginring Scincs and Tchnologis REGENERATIVE THERAPY OF OSTEOCHONDRAL LESIONS: FACTORS THAT INFLUENCE CELLULAR MEDICINE RIZZOLI Biomdica Bionginring Scincs and Tchnologis Rol of diaphragmatic ultrasonography in th diagnosis and prognosis in rspiratory valuation in patint with amyotrophic latral sclrosis (Eco.Di.SLA) Emilia Romagna Clinicoassistnzial Cardiovascular and Rspiratory Scincs Acquisition, analysis and managmnt of clinical, social and go mdical data aiming at studying and dvloping pidmiological modls of disass with high social and conomic impact in Calabria rgion Calabria Biomdica Population Scincs and Epidmiology Pagina 191 di 228

192 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not EVALUATION OF STANDARD VIDEODERMATOSCOPY AND LOW COST VIDEOMICROSCOPES AS NON INVASIVE DIAGNOSTIC TOOLS FOR SCABIES AND OTHER SKIN ECTOPARASITOSES OF THE MIGRANTS: A COST EFFECTIVE ANALYSIS Sicilia Clinicoassistnzial Infctious Disass and Microbiology Enhancd rcovry program in pancratic surgry. An innovativ approach to improv outcom and optimiz rsourcs. Lombardia Clinicoassistnzial Halthcar Dlivry and Mthodologis Rol of mirna/mrna ntwork and msnchymal stromal clls in th pathognsis of th aortopathy associatd with bicuspid and tricuspid aortic valv and as arly biomarkrs Campania Biomdica Cardiovascular and Rspiratory Scincs Idntification of imaging biomarkrs for th biological charactrisation of high grad crbral tumours. HUMANITAS Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Phosphotargting of NG2/CSPG4 in Chordoma ISTITUTO TUMORI MILANO Clinicoassistnzial Prformanc of univrsal Lynch Syndrom scrning using Mismatch Rpair (MMR) Immunohistochmical tst ISTITUTO TUMORI MILANO Clinicoassistnzial Pagina 192 di 228

193 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F FDG PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT Sicilia Clinicoassistnzial Evaluation of Biomarkrs of Rsistanc/Snsitivity to diffrnt Adjuvant Endocrin Tratmnts in a Randomizd Trial to Optimiz Tratmnt Dcision Making and to Idntify Novl Pharmacological Targts in Estrogn Rcptor (ER) Positiv Brast Canc PASCALE Biomdica Gntics of tast prcption, lif styl, halth status and colorctal cancr risk. Pimont Biomdica Gns, Gnoms and Gntics Gntic and nvironmntal dtrminants of lft vntricular mass and artrial function: a twin study Umbria Biomdica Cardiovascular and Rspiratory Scincs Rnal Dnrvation in Patints with Advancd ChronicHart Failur (NYHA f. C. III), Nding High Loop Diurtic Dos. MULTIMEDICA Clinicoassistnzial Cardiovascular and Rspiratory Scincs Dvlopmnt and tsting of an activ, light wight, warabl lowr limb xosklton for gait assistanc in oldr prsons. DON GNOCCHI Biomdica Musculoskltal, Oral and Skin Scincs Pagina 193 di 228

194 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Slf monitoring tst basd on prfrntial hypracuity primtry vrsus standard clinical monitoring procdurs in dtcting th ncssity of rptition of intravitral tratmnt with anti angiognic drugs for patints affctd by novascular ag rlatd Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis 22, An intgrativ approach to th dsign of rational targtd thraputics in cholangiocarcinoma REGINA ELENA Biomdica Oncology 1 Basic Translational 22, Novl computr basd motor rhabilitation and brain connctivity in Huntington's Disas SANTA LUCIA Biomdica Brain Disordrs and Nuroscinc 22, TISSUE ENGINEERING IN ORGAN TRASPLANTATION: THE USE OF POLYMERIC SCAFFOLDS IN HEPATIC VASCULAR AND BILIARY RECOSTRUCTION Sicilia Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 22, Evaluation of diagnostic accuracy in intrprtation of scrning mammograms: dvlopmnt of advancd ddicatd softwar ISTITUTO TUMORI MILANO Clinicoassistnzial Risk, Prvntion and Halth Bhavior 22, Th Italian National Quitlin and thr Rgional Tlphon Srvics to follow smokrs in thir quit attmpts through tlphon counslling and facilitating contacts with local Tobacco Cssation Srvics Toscana Clinicoassistnzial Risk, Prvntion and Halth Bhavior 22, Pagina 194 di 228

195 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not AN INNOVATIVE TECHNOLOGICAL MEDEA MODEL FOR REHABILITATION OF CHILDREN WITH CEREBRAL PALSY: VIRTUAL REALITY (VR), VIDEO GAMES AND ON LINE TUTORING FOR COORDINATIVE TRAINING AND HOME CARE ASSISTANCE. EFFICACY AND COST AFFORDANCE Clinicoassistnzial Emrging Tchnologis and Training in Nuroscincs 22, MOLECULAR DISSECTION OF THE PI3K/AKT PATHWAY IN GLIOBLASTOMA: IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL TARGET THERAPIES BASED ON SMALL MOLECULES. CASA SOLLIEVO SOFFERENZA Biomdica Oncology 1 Basic Translational 22, Auditory survillanc: dsigning tools and protocols for an ffctiv follow up aftr nwborn haring scrning BURLO GAROFALO Clinicoassistnzial Intgrativ, Functional, and Cognitiv Nuroscinc 22, Dvlopmnt of pr oprativ invstigation tools and surgical procdurs for th tratmnt of movmnt disordrs in childhood OSPEDALE BAMBINO GESU' Clinicoassistnzial Brain Disordrs and Nuroscinc 22, Non coding RNA Signaturs: Novl Biomarkrs for arly dtction of Colorctal Cancr CASA SOLLIEVO SOFFERENZA Biomdica 22, NOVEL STRATEGIES FOR MOLECULAR DIAGNOSIS AND RISK STRATIFICATION OF PATIENTS WITH CHRONIC HEART FAILURE. Campania Biomdica Cardiovascular and Rspiratory Scincs 22, Pagina 195 di 228

196 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Us of lctrical stimulation in th rhabilitation of dysphagia aftr strok: randomizd controlld trial to tst th ffctivnss of tratmnt on outcom Emilia Romagna Clinicoassistnzial Brain Disordrs and Nuroscinc 22, Amniotic stm clls to improv congnital kidny damag: a ftal lamb modl SAN MATTEO Biomdica Digstiv, Kidny and Urological Systms 22, Physically drivn nanocarrirs for th controlld dlivry of apomorphin and lvodopa in Parkinson's disas AUXOLOGICO Biomdica Bionginring Scincs and Tchnologis 22, A RANDOMIZED OPEN LABEL STUDY COMPARING EVEROLIMUS AT DIFFERENT DOSES WITH STANDARD THERAPY IN THE ABILITY TO DELAY THE PROGRESSION OF DIABETIC NEPHROPATHY Puglia Biomdica Digstiv, Kidny and Urological Systms 22, A Twin Study on th Rlation btwn Psychological and Immunological Functioning Istituto Suprior di Sanita' Biomdica Biobhavioral and Bhavioral Procsss 22, Biological scaffold and clls for soft tissu rgnration aftr dbulking surgry in oncologic fmal patints Emilia Romagna Biomdica 22, A systmatic us of computr support finalizd to prvnt th rnal toxicity of drugs intraction and dosag. Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis 22, Pagina 196 di 228

197 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Circulating ndothlial prognitor clls as potntial prdictiv and prognostic markrs inmtastatic colorctal cancr patints Toscana Biomdica 22, IS CHOLESTERYL ESTER STORAGE DISEASE AN UNDER RECOGNIZED CAUSE OF ATHEROSCLEROSIS AND LIVER DYSFUNCTION? Pimont Biomdica Vascular and Hmatology 22, Molcular profiling of EGFR mutant lung carcinoma through analysis of liquid biopsis PASCALE Clinicoassistnzial 22, Dvlopmnt and validation of a production procss for homologous srum y drops and fibrin platlt gl prparation from umbilical cord blood. Vnto Biomdica Vascular and Hmatology 22, Inappropriat mdical prscriptions: a ntwork for patints' safty. From pidmiology to mdical lgal aspcts: valuation of an ducativ/informativ stratgy for prvntion. Molis Clinicoassistnzial Halthcar Dlivry and Mthodologis 22, Radiation xposur optimization by wirlss tchnology for profssionals involvd in th managmnt and car of patints undrgoing thrapy with radionuclids. Implmntation of nvironmntal monitoring. CROB Clinicoassistnzial Halthcar Dlivry and Mthodologis 22, Pagina 197 di 228

198 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Adjunctiv corticostroid tratmnt in critically ill patints with sptic shock. A multicntr randomisd blindd placbo controlld trial of hydrocortison in critically ill patints with sptic shock SAN RAFFAELE MILANO Biomdica Infctious Disass and Microbiology 22, Idntification of halth intrvntions to b offrd to populations living in aras affctd by nvironmntal pollution: dvlopmnt and pilot application of an vidnc basd approach. Pimont Clinicoassistnzial Population Scincs and Epidmiology 22, Comparisons of Hpatic Transint Elastography and Acoustic Radiation Forc Impuls Masurmnts of Livr and Spln, Prformd Bfor Livr Biopsy. Sicilia Clinicoassistnzial Digstiv, Kidny and Urological Systms 22, Exom squncing to idntify nw disas gns for Essntial Trmor Sicilia Biomdica Gns, Gnoms and Gntics Monitoring and biofdback for postur analysis on th workplac Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis Angiognic and anti angiognic factors in childrn with Infantil Hamangioma: how thy chang undr tratmnt with oral propranolol. Toscana Biomdica Vascular and Hmatology IDENTIFICATION OF A CIRCULATING micrornas SIGNATURE ABLE TO PREDICT RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN ADVANCED OVARIAN CANCER Umbria Clinicoassistnzial Pagina 198 di 228

199 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not KILLER IMMUNOGLOBULIN LIKE RECEPTOR AND HUMAN ENDOGENOUS RETROVIRUS K (HERVK) AS TUMOR BIOMARKERS OF ONCOGENESIS AND RESPONSE TO TREATMENT IN ONCO HEMATOLOGY Sardgna Clinicoassistnzial AGEING RELATED HEART AND BONE FUNCTIONAL IMPAIRMENTS: A CLINICAL AND EXPERIMENTAL STUDY ON POTENTIALLY SHARED PATHOGENETIC PATTERNS SAN RAFFAELE MILANO Biomdica Cardiovascular and Rspiratory Scincs "Charactrization of mylopoisis disordrs: unrvaling th rol of GATA2 and rlatd factors in prdicting patints' clinical outcom and stablishing a timly tratmnt" Toscana Biomdica Gns, Gnoms and Gntics Study of gn xprssion of th major allrgns producd by Anisakis snsu lato for risk assssmnt in fishry products of gratst commrcial intrst along Tyrrhnian coast IZSLT Biomdica Vtrinary Giv scrning a chanc SAN MATTEO Clinicoassistnzial AIDS and Rlatd Rsarch Pagina 199 di 228

200 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Non invasiv prnatal tsting: ftal anuploidis risk dtrmination, mutation analysis in prgnancis at risk for monognic disordrs and circulating cll fr DNA dosag as a markr of prgnancy outcom. Toscana Biomdica Gns, Gnoms and Gntics Comparison of prsonality and priphral biological markrs in young Italians with and without intrnt addiction Toscana Biomdica Brain Disordrs and Nuroscinc Strngth arobic training to trat priphral artrial disas: a nw approach to contrast athrosclrosis and disability. Vnto Clinicoassistnzial Cardiovascular and Rspiratory Scincs Nxt gnration squncing and nw disas modls to idntify th molcular mchanisms and thraputic targts of astrocyt dysfunction in autism pilpsy phnotyp Istituto Suprior di Sanita' Biomdica Brain Disordrs and Nuroscinc Spatially variant prscription of dos radiation according to hypoxic tumor distribution assssd by hypoxia markrs and biological imaging: a phass I II study in non small cll lung cancr. CROB Biomdica CoNan Cobalt Nanoparticls for Multimodal Molcular Imaging Emilia Romagna Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Pagina 200 di 228

201 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Combining intgratd oxidativ protomic and mtabolism profils for th idntification of novl pathogntic mchanisms and thrapis against hyprtrophic cardiomiopathy and pigmntary rtinopathy in mitochondrial trifunctional protin OSPEDALE BAMBINO GESU' Biomdica Gns, Gnoms and Gntics Impact of Tlmdicin in th managmnt of vry ldrly patints affctd by svr chronic hart failur: clinical outcoms, conomic and quality of lif analysis I.N.R.C.A. Clinicoassistnzial Halthcar Dlivry and Mthodologis Intgratd us of multipl tchniqus for th undrstanding and tratmnt of spatial awarnss and motor disordrs following strok Pimont Biomdica Brain Disordrs and Nuroscinc Association btwn svr psoriasis and subclinical athrosclrotic vascular damag ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Cardiovascular and Rspiratory Scincs Scurity in animal nutrition: Th us of formaldhyd and zinc as additivs for animal fd production IZSSI Biomdica Vtrinary AN INTEGRATED WORKFLOW TO DISCOVER COMPOUNDS ABLE TO MODULATE THE BONE MORPHOGENETIC PROTEIN SIGNALING GASLINI Biomdica Cll Biology Pagina 201 di 228

202 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not ErbB rcptors and TGF bta crosstalk in H.pylori rlatd in gastric disass: molcular signalling and thraputic opportunitis Abruzzo Biomdica Oncology 1 Basic Translational 23, AN INTEGRATIVE APPROACH TO EPISODIC VERTIGO SAN RAFFAELE MILANO Clinicoassistnzial Molcular, Cllular, and Dvlopmntal Nuroscinc 23, Assssmnt of horizontal transfr of toxin and antibiotic rsistanc gns btwn pathognic clostridia and probiotic bactria. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 23, RECONSTRUCTION OF HUMAN URETHRA WITH A REGENERATIVE MEDICINE PROCOL IN URETHRAL STRICTURE REPAIR Umbria Biomdica Digstiv, Kidny and Urological Systms 23, LIPID METABOLISM AND VASCULAR HEALTH IN MORBID OBESITY: IMPACT OF BARIATRIC SURGERY Umbria Clinicoassistnzial Vascular and Hmatology 23, p73/hif 1alpha axis in physiological and pathological conditions ISTITUTO DERMOPATICO DELL'IMMACOLATA Biomdica Oncology 1 Basic Translational 23, MOLECULAR AND SEROLOGICAL SURVEY FOR EMERGING ENTERIC VIRUSES WITH ZOONOTIC POTENTIAL IN WILD ANIMALS IN ITALY IZSPLV Biomdica Vtrinary 23, Pagina 202 di 228

203 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Vitamin D and Microbiota in colorctal cancr I.E.O. Clinicoassistnzial 23, In vitro and in vivo studis of homocystin inducd nurodgnration and potntial protctiv/rparativ ffcts of nutracutical compounds Sicilia Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 23, Study of an innovativ PET with nlargd fild of viw (FOV) providd with vry high snsitivity and fficincy. Essntial for th vry arly diagnosis of cancr, INFLAMMATORY as wll as dgnrativ disass and thir mor consrvativ tratmnt. Const SAN MATTEO Biomdica Bionginring Scincs and Tchnologis 23, "Primary car managmnt" to addrss patints with complx halth car nds in an ara basd halth car systm Vnto Clinicoassistnzial Halthcar Dlivry and Mthodologis 23, Cancr and adolscnc: improv undrstanding of clinical and traslational rsarch C.R.O. AVIANO Clinicoassistnzial Halthcar Dlivry and Mthodologis 23, RANDOMIZED PLACEBO CONTROLLED STUDY OF LOW MOLECULAR WEIGHT HEPARIN (LMWH) FOR THE PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN NEWLY DIAGNOSED NON HODGKIN LYMPHOMA PATIENTS (NHL) Pimont Biomdica Vascular and Hmatology 23, Pagina 203 di 228

204 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not IMPACT OF A RESCUE COURSE OF ANTENATAL CORTICOSTEROIDS ON DEVELOPING BRAIN: A RANDOMISED CONTROLLED TRIAL ON SHORT TERM AND LONG TERM OUTCOMES Emilia Romagna Biomdica Brain Disordrs and Nuroscinc 23, Pathogntic aspcts of bolavirus infction SPALLANZANI Biomdica Infctious Disass and Microbiology 23, Dvlopmnt of an intgratd risk communication wb basd modl associatd with th consumption of food additivs IZSVE Biomdica Halthcar Dlivry and Mthodologis 23, Rigorous maintnanc of normoxia vrsus hyproxia in critically ill patints admittd in intnsiv car unit. A randomizd multicntr study. Emilia Romagna Clinicoassistnzial Brain Disordrs and Nuroscinc 23, Diagnostic and thraputic cours of oncologic patints with focus on biological drugs Sardgna Clinicoassistnzial 23, Chronic kindy disas, Artrial Stiffnss and Targt blood prssur (Th CAST Study) MAGGIORE Clinicoassistnzial Cardiovascular and Rspiratory Scincs 23, Providing indication for novl thraputic stratgis and drugs to improv outcom of rcurrnt ostosarcoma patints RIZZOLI Biomdica Pagina 204 di 228

205 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Italian study on gn nvironmnt intractions in lymphoma atiology: translational aspcts Toscana Biomdica Population Scincs and Epidmiology Srum Cholstrol fflux capacity (CEC) Emilia Romagna as an indx of plaqu vulnrability in patints with carotid athrosclrosis: corrlation with mbolic potntial valuatd by trans cranial Dopplr (TCD) Clinicoassistnzial Cardiovascular and Rspiratory Scincs Organic vs convntional: sprading IZSSA Biomdica Vtrinary assssmnt of crtain dairy hrds disass DEVELOPMENT AND CLINICAL APPLICATION OF A NOVEL RADIOGUIDED SURGERY TECHNIQUE IN BRAIN TUMORS CARLO BESTA Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring DIAMOND (DIt, Activity and MONitoring): a prsonalizd lifstyl intrvntion trial for brast cancr patints. I.E.O. Clinicoassistnzial Autologous Adipos Tissu Drivd Msnchymal Stm Clls Enrichmnt and Isolation for th Tratmnt of Patints with Dgnrativ Hip Ostoarthritis Pimont Clinicoassistnzial Musculoskltal, Oral and Skin Scincs Human Ewing Sarcoma Family Tumor (ESFT) Rvisitd From Cancr Stm Clls (CSCs) toth Epigntic Rgulation: cross talk btwn ncrna and DNA mthylation Lombardia Biomdica Oncology 1 Basic Translational Pagina 205 di 228

206 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Box of rain for Critical limb ischmia: a phas II singl arm trial. SAN MATTEO Clinicoassistnzial Cardiovascular and Rspiratory Scincs Intgratd approach to optimiz th tratmnt with S(+) scitalopram in MDD patints. Provincia autonoma Bolzano Clinicoassistnzial Biobhavioral and Bhavioral Procsss Cholin mtabolism assssd by Fluorocholin Positron Emission Tomography for monitoring th rspons to trastuzumab in advancd brast cancr I. O. V. Clinicoassistnzial Prsonalizd tratmnt of arly/locally advancd and mtastatic brast cancr patints by gnomic analysis Abruzzo Biomdica 24, Mobil halth car systm for symptoms monitoring in patints with mtastatic brast cancr rcving targtd trapy Abruzzo Clinicoassistnzial 24, Studis on th rol of th nuronastrocyt microglia triad in th pathognsis of crbral ischmia Toscana Biomdica Brain Disordrs and Nuroscinc 24, Complications in spinal surgry ar too high. A prospctiv monitoring to rduc and avoid thm. RIZZOLI Clinicoassistnzial Risk, Prvntion and Halth Bhavior 24, Ontology and radmission: rol of halth communications tchnologis in frail patints dischargd from intrnal mdicin dpartmnt Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis 24, Pagina 206 di 228

207 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Epidmiological mthodology of Salmonlla spp in Puglia isolatd from human and non human sourcs: isolation, idntification, drug rsistanc and clustr analysis. Puglia Clinicoassistnzial Infctious Disass and Microbiology 24, Escluso dal Finanziamnto pr conflitto con critri bando: Richista fondi al Ministro infrior a Immunoprofiling as prdictiv biomarkr to slct patints candidat to b tratd with agnts modulating immun chck points ISTITUTO TUMORI MILANO Clinicoassistnzial 24, Outcom and socio conomic impact of th dfinitiv tratmnt for th cardiac dvic rlatd infctions Sicilia Clinicoassistnzial Halthcar Dlivry and Mthodologis 24, IODINE NUTRITIONAL STATUS IN NEWBORNS AND CHILDREN 1 5 YEARS OLD: A STRATEGY TO REDUCE IODINE DEFICIENCY IN HIGH RISK CATEGORIES OF THE POPULATION GASLINI Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 24, Risks of Occupational xposur to Nanomatrials: an intgratd approach to valuat xposur and halth ffcts at workplac INAIL Biomdica Bionginring Scincs and Tchnologis 24, A study of th molcular and cllular mchanisms inducd by macronvironmnt (nrichd nvironmnt) on tumor micronvironmnt of xprimntal mous glioma NEUROMED Biomdica Oncology 1 Basic Translational 24, Pagina 207 di 228

208 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Evaluation of th rol of pathogns and nvironmntal factors in dtrmining Unusual Mortality Evnts (UMEs) of ctacans in th Mditrranan, and dvlopmnt of a UMEs prdictiv modl IZSPLV Biomdica Vtrinary 24, Novl diagnostic/prognostic prspctivs of 18KDa Translocator Protin (TSPO) masurmnt in an Alzhimr Disas (AD) mous modl: a micropet study. Toscana Biomdica Brain Disordrs and Nuroscinc 24, Modulating th dynamic molcular intrplay btwn carnosin lik pptids, mtal ions and abrrant ß amyloid pptids in CNS and in Alzhimr's Disas: intgratd modl approach for countracting nurodgnration SAN RAFFAELE MILANO Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 24, Idntificazion di sistmi di rilascio ottimali pr i Nuclic Acid Basd Drugs studio di mccanismi di azion in alcuni modlli di patologi uman infiammatori /Idntification of optimal dlivry systms for th Nuclic Acid Basd Drugs and study of t Campania Clinicoassistnzial Cardiovascular and Rspiratory Scincs 24, Adhrnc to Mditrranan Dit and prgnancy outcom: clinical, biochmical and pigntic ffcts. Campania Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 24, PREDICTIVE GENETIC ALTERATIONS IN OVARIAN CANCER (PREGIO) Emilia Romagna Biomdica 24, Pagina 208 di 228

209 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Modulating sizur xprssion and brain damag with convntional and innovativ thraputic stratgis in a rat modl of human cortical dysplasia CARLO BESTA Biomdica Brain Disordrs and Nuroscinc 24, EVALUATING THE COST EFFECTIVENESS OF AN ORGANIZATIONAL MODEL OF RISK ANALYSIS AND PROBLEM SOLVING FOR HEALTHCARE ASSOCIATED INFECTIONS Sicilia Clinicoassistnzial Infctious Disass and Microbiology 24, Epidmiology and cost valuation of strok in Italy Toscana Clinicoassistnzial Halthcar Dlivry and Mthodologis 24, PROSTATE CANCER: A STUDY ON THE MOLECULAR MECHANISMS UNDERLYING THE DEVELOPMENT OF CASTRATION RESISTANT PHENOTYPE IRCCS AOU San Martino IST (Gnova) Biomdica Oncology 1 Basic Translational 24, DEVELOPMENT, VALIDATION AND CLINICAL APPLICATION OF NEXT GENERATION SEQUENCING MULTIGENIC PIPELINES FOR DETECTION AND DYNAMIC CHARACTERIZATION TOWARD PERSONALIZATION OF CANCER PREVENTION AND TREATMENT. Abruzzo Biomdica 24, INSECTS FOR FEED: EXPOSURE ASSESSMENT FROM FEED TO FOOD IZSPLV Biomdica Vtrinary Pagina 209 di 228

210 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A NUTRITIONAL APPROACH TO CANCER: A PILOT STUDY IN TWO AREAS OF CAMPANIA CHARACTERIZED BY DIFFERENT ENVIRONMENTAL RISK Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational Continuous car modl for ldrly patints who nd hospital rsourcs in th last yars of thir lif Lombardia Clinicoassistnzial Halthcar Dlivry and Mthodologis Addrssing th pancratic bta clls for th prvntion and tratmnt of typ 2 diabts Toscana Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Srum tryptas and chymas: nw biomarkrs in patints with acut coronary syndrom. Lombardia Clinicoassistnzial Cardiovascular and Rspiratory Scincs Rcognition of a spcific mtabolic fingrprint of diabtic cardiomyopathy, in ordr to clarify its pathophysiology, dlay clinical manifstations of disas and improv th tratmnt Sardgna Biomdica Cardiovascular and Rspiratory Scincs Dvlopmnt of a dos rport softwar and its application in ach radiology dpartmnt of Sicilian Public Hospitals Sicilia Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring TP53 Polymorphisms in glioblastoma and Had & Nck cancrs: th clinical impact of corrlation btwn gnomic information and radio chmiothrapy tratmnt. Lombardia Biomdica Pagina 210 di 228

211 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Ostopnia and ostoporosis in HIV infctd patints: th rol of th virus and antirtroviral drugs. Emilia Romagna Biomdica AIDS and Rlatd Rsarch Shdding nw light on wlldiffrntiatd follicular drivd thyroid carcinoma: microfluidic thyroid on chip dvic as a tool for th idntification of novl diagnostic/prognostic biomarkrs toward a patint spcific tratmnt Lazio Biomdica Oncology 1 Basic Translational Gn xprssion profiling and protomic analysis on tndons and singl muscl fibrs from childrn with Crbral Palsy HUMANITAS Biomdica Musculoskltal, Oral and Skin Scincs Flavors and mtabolic altrations rlatd to impropr fding bhavior in mammals Istituto Suprior di Sanita' Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Discovry of distinct plasma micro RNA xprssion pattrn in ndomtriosis and ndomtriosis associatd ovarian cancr Sicilia Biomdica Monitoring infction in complx wounds in pdiatric patints. Nw stratgis and modl for diagnostic, thraputic and clinical car for prvntion of infction OSPEDALE BAMBINO GESU' Clinicoassistnzial Halthcar Dlivry and Mthodologis 25, Flow dynamic valuation of ndovascular aortic arch rconstruction by cardiovascular MRI with 4D tchnology and computational analysis Vnto Clinicoassistnzial Bionginring Scincs and Tchnologis 25, Pagina 211 di 228

212 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Cration and implmntation of an intgratd ntwork for th managmnt of diabtic foot Sicilia Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 25, Common pathognic stps in nuromuscular disass: disscting th rol of mir 21 and mir 206 in SMA and ALS mic and human patints. CARLO BESTA Biomdica Molcular, Cllular, and Dvlopmntal Nuroscinc 25, Dtction of prdictiv markrs for thraputic stratification of salivary glands tumors PASCALE Clinicoassistnzial 25, This study aims to invstigat th bioavailability, fficacy and safty of pdiatric frindly formulation not commrcially availabl, cntrally prpard by th Hospital Pharmacy OSPEDALE BAMBINO GESU' Clinicoassistnzial Bionginring Scincs and Tchnologis 25, Patint drivd xnografts to xplor th usfulnss of prclinical modls on prsonalizd mdicin Emilia Romagna Biomdica 25, Nw prspctivs in th prvntion of Diabts dpndnt cognitiv dclin Calabria Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs 25, Comparison among diffrnt chronic disas modls in Lombardia Rgion and analysis and dsign of innovativ stratgis to improv quality of car and optimis rsourcs' utilisation. Intgration of th diffrnt modls, with halth and tlmdicin su Lombardia Clinicoassistnzial Halthcar Dlivry and Mthodologis 25, Pagina 212 di 228

213 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prsonnl and workrs with pacmakr or implantabl dfibrillator in th MRI nvironmnt: mthods and xprimntal data collction for th risk assssmnt Istituto Suprior di Sanita' Biomdica Halthcar Dlivry and Mthodologis 25, Isolation, immunophnotypic molcularbiological charactrization and banking of human msnchymal stm clls; idntification of novl, sustainabl mthods for x vivo xpansion and unilinag diffrntiation for clinical applications Calabria Biomdica Musculoskltal, Oral and Skin Scincs 25, ROLE OF NGF IN CHRONIC ALLOGRAFT NEPHROPATY Calabria Biomdica Digstiv, Kidny and Urological Systms 25, Ticagrlor vs. aspirin for prvntion of cardiovascular vnts in aspirin tratd patints with strok or TIA. Umbria Clinicoassistnzial Brain Disordrs and Nuroscinc Nw halth car modl for intgratd multidisciplinary managmnt and surgical tratmnt of complx plvic floor dysfunctions: conomic valuation, carflow managmnt and applicability to othr clinical srvics Emilia Romagna Clinicoassistnzial Halthcar Dlivry and Mthodologis Dvlopmnt of a modl of cardiac survillanc for cancr patints candidats to molcular targtd agnts thrapis. Campania Clinicoassistnzial A novl intgratd approach to th diagnosis and prognosis of Disordrs of Consciousnss Emilia Romagna Clinicoassistnzial Brain Disordrs and Nuroscinc Pagina 213 di 228

214 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not camp PCT CGRP axis as a potntial molcular targt in th diagnosis and tratmnt of pr clampsia BURLO GAROFALO Biomdica Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Early idntification of lft vntricular dysfunction du to anthracyclins and novl HER 2 targtd thrapis in adjuvant tratmnt of brast cancr: rol of nw imaging tchniqus and biomarkrs PASCALE Biomdica Cardiovascular and Rspiratory Scincs Modulation of glycosphingolipid mtabolism for nhancing cll rsistanc to hypoxic strss: a nw possibl thraputic approach for ischmic cardiovascular disass SAN DONATO Biomdica Cardiovascular and Rspiratory Scincs Effcts of an ndoscopic tchniqu, th duodnal jjunal bypass linr, on body wight, glyco mtabolic control and som adipocytokins in typ 2 diabtic patints SAN MATTEO Clinicoassistnzial Endocrinology, Mtabolism, Nutrition and Rproductiv Scincs Analysis of th impact of systmic autoimmun disass on frtility, family planning, and on th family structur of patints. Toscana Clinicoassistnzial Population Scincs and Epidmiology Protocol for th tratmnt of Critical Limb Ischmia no option thrapy with bon marrow stm cll concntrat harvstd with a point of car dvic Emilia Romagna Clinicoassistnzial Cardiovascular and Rspiratory Scincs 26, Pagina 214 di 228

215 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Mtagnomics and mdicin: analysis and modling of gut and gastric microbiota in Barrtt's sophagus and sophagitis. Toscana Clinicoassistnzial 26, On Halth Approach for Listriosis: intgration of th xisting laboratory survillanc and control activitis in th mdical and food/vtrinary sctors Istituto Suprior di Sanita' Biomdica Vtrinary 26, Biological faturs,rol of biomarkrs and xtnt of surgical rsction in Right Colon Cancr: idntification of a scor of probability of local and mtastatic sprad for prsonalizd surgry Emilia Romagna Biomdica 26, Intgrating srum mtabolomic, circulating micrornas profiling and adrnomdullin lvls in arly scrning of pancratic carcinoma in nw onst diabts patints Lazio Biomdica 26, Evaluation of nw approachs for prvntion and control of Lgionlla and othr watrborn pathogns through th analysis of microbiom of drinking watr systms. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 26, Population basd pidmiology of arly acquird disabilitis: to qualify and quantify th unmt car nds of disabld individuals, to xplor th implmntation of targtd and innovativ intrvntion. Abruzzo Clinicoassistnzial Population Scincs and Epidmiology 26, Pagina 215 di 228

216 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not TWIN ANALYSIS OF FINE NEEDLE ASPIRATION AND CIRCULATING TUMOR CELLS FOR GENOTYPE AND PHENOTYPE CHARACTERIZATION OF ADVANCED LUNG CANCER Toscana Clinicoassistnzial 26, Nitrosation of pharmacuticals of clinical us in humans: mchanism of transformation in human saliva at th acidic ph of th stomach, and valuation of th associatd potntial gnotoxic and carcinognic risk. Istituto Suprior di Sanita' Biomdica Oncology 1 Basic Translational 26, High throughput, population wid, rflx tsting of colo rctal cancr: molcular charactrization, idntification of individualizd thrapy targts and prvntion of familial cass IRCCS AOU San Martino IST (Gnova) Clinicoassistnzial 26, Idntification and validation of a Panl of suitabl biomarkrs usful for radiation Risk Assssmnt associatd with low and protractd DOSs ncountrd in nuclar mdicin (PARADOS) Istituto Suprior di Sanita' Biomdica 26, Diagnostic and thraputic dvics mitting lctromagntic filds: ffctivnss and safty for patints and workrs Istituto Suprior di Sanita' Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 26, Eracl: daring with motions. Psychological support in th srvics of cancr patints and thir familis Sicilia Clinicoassistnzial 26, Pagina 216 di 228

217 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th Activity Basd Managmnt applid to a comprhnsiv cancr cntr. IRCCS AOU San Martino IST (Gnova) Clinicoassistnzial Halthcar Dlivry and Mthodologis 26, Prinatal Asphyxia, Nuroprotctiv Stratgis and Brain Biomarkrs Pimont Biomdica Brain Disordrs and Nuroscinc 26, Saf Nanotchnology: Assssing Nanoparticl Toxicity of Environmntal Intrst by an Intgratd In Vitro Cll Basd Tst Stratgy. MAUGERI Biomdica Bionginring Scincs and Tchnologis 26, Th apicoplast translational apparatus as a targt for th dvlopmnt and charactrization of nw antimalarial agnts. Istituto Suprior di Sanita' Biomdica Infctious Disass and Microbiology 26, Epigntic and molcular mchanisms involvd in th onst/progrssion of vulvar lichn sclrosus and vulvar squamous cll carcinoma. Emilia Romagna Biomdica Oncology 1 Basic Translational Improvmnt of diagnostic accuracy of FNA and brushing citology by FISH tchniqu and K ras mutation analysis in patints with suspctd pancratobiliary malignancis Friuli Vnzia Giulia Clinicoassistnzial Rsarch, dsign, analysis, dvlopmnt, tst and tuning of a wb basd informatic systm to b usd vn on Tablt Android to support and coordinat all activitis of inspction, monitoring and sampling In th fild of occupational safty, building sits Lazio Biomdica Halthcar Dlivry and Mthodologis Pagina 217 di 228

218 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A multidisciplinary and intgratd study of th bhavioral, gntics and nurobiological corrlats of impulsiv and violnt bhavior. Implications for th dvlopmnt of rhabilitation stratgis in convictd offndrs. Toscana Biomdica Biobhavioral and Bhavioral Procsss High dfinition Vido Thrmography (VTG): a nw mthod of imaging in paraclinical diagnosis of Non Mlanoma Skin Cancrs and in th "Skin Cancrization Fild" SAN GALLICANO Clinicoassistnzial Cancr survivorship: xtnsion of th italian mdical psychosocial paradigm to prsons with activ disas undr thraputical control. C.R.O. AVIANO Clinicoassistnzial Risk Communication for food born disas prvntion IZSME Biomdica Vtrinary HIV 1 Env protins variability in variants from diffrnt HIV 1 subtyps and rcombinant forms and its corrlation with disas stag and rsistanc/snsitivity to nutralization. Istituto Suprior di Sanita' Biomdica AIDS and Rlatd Rsarch Th nw implmntation of EUntHTA Cor Modl by intgrating th Analytic Hirarchy Procss: a validation of this mthodology usd in halth tchnology assssmnt for supporting halth car dcision making and its application for driving th procss of ad OSPEDALE BAMBINO GESU' Clinicoassistnzial Halthcar Dlivry and Mthodologis Pagina 218 di 228

219 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th fficacy of tratmnts of priimplant disass on oral halth SAN RAFFAELE MILANO Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring Gnom wid association study on Follicular lymphoma ONCOLOGICO DI BARI Biomdica Un innovativ way to improv cancr patint outcoms. Th ffctivnss of a nurs ld tlphon follow up aftr thraputic cancr tratmnt. A randomizd controlld trial. Pimont Clinicoassistnzial Halthcar Dlivry and Mthodologis 27, PREVENTION OF REPEATED FIRST TRIMESTER VOLUNTARY ABORTION AMONG WOMEN WITH LOW CONTRACEPTIVE COMPLIANCE IMPROVES REPRODUCTIVE HEALTH AND REDUCES SOCIAL AND HOSPITAL COSTS Sicilia Clinicoassistnzial Halthcar Dlivry and Mthodologis 27, Nxt Gnration squncing in Midlin Dfcts associatd with hypopituitarism GASLINI Clinicoassistnzial Gns, Gnoms and Gntics 27, Rol of migrants in tubrculosis, vctors and vctor born disas sprad IZSSI Biomdica Infctious Disass and Microbiology 27, Influnza pathways: rlas and xposur assssmnt to idntify th virus maintnanc stratgis IZSPLV Biomdica Vtrinary 27, Pagina 219 di 228

220 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Strngth and rsistanc Exrcis Thrapy (ET) to control Aromatas Inhibitors (AIs) muscloskltal advrs ffcts and improv Quality of Lif (QoL) in ldrly brast cancr survival womn PASCALE Clinicoassistnzial 27, Rducd aspirin action in diabtic patints at high risk of cardiovascular vnts: cllular and molcular studis on mgakaryocyt prognitor clls and platlts. Istituto Suprior di Sanita' Biomdica Vascular and Hmatology 27, Evaluation of cognitiv impairmnt in patints with svr stnosis of th xtracranial carotid artris: bnficial ffcts of carotid artry stnting (CAS) Campania Biomdica Cardiovascular and Rspiratory Scincs 27, Th morphomtric study of nrv: suprrsolution Mosaicing analysis (PNS MoMa) SAN RAFFAELE MILANO Biomdica Bionginring Scincs and Tchnologis 27, Long trm vs short trm survivors patints with Malignant Plural Msothlioma: molcular markrs, scrtom and xom analysis Toscana Biomdica 27, Impact of an Enhancd Rcovry Aftr Surgry (ERAS) program on physical prformanc and muscl strngth in ldrly patints undrgoing lctiv colorctal rsction for cancr Emilia Romagna Clinicoassistnzial Surgical Scincs, Biomdical Imaging, and Bionginring 27, Pagina 220 di 228

221 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not A ddicatd informatics tool to assist both mdical dcision making and costs burdn valuation in surgry intrvntion for thyroid patints REGINA ELENA Clinicoassistnzial 27, Towards a prsonalizd tratmnt of mtastatic mlanoma: study on intrinsic rsistanc to MAPK inhibitors. I. O. V. Clinicoassistnzial 27, Can dit and mtabolic factors affct fficacy and toxicity of chmothrapy in cancr patints? Sicilia Clinicoassistnzial PENETRATION OF METAL NANOPARTICLES THROUGH BIOLOGICAL MEMBRANES AND IMMUNOLOGICAL RESPONSE Friuli Vnzia Giulia Biomdica Musculoskltal, Oral and Skin Scincs Prvntion of post hospital syndrom in ldrly through nutritional support Calabria Clinicoassistnzial Biology of Dvlopmnt and Aging Falls Prvntion in hospitals and longtrm car through intllignt vido survillanc and monitoring of fallrlatd bhavioral pattrns. Liguria Clinicoassistnzial Halthcar Dlivry and Mthodologis 28, A mdical dvics submission tmplat for th Italian contxt (TmplaIT) Agnzia pr i Srvizi Sanitari Rgionali Clinicoassistnzial Halthcar Dlivry and Mthodologis 28, Pagina 221 di 228

222 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Nurobhavioral problms in autistic spctrum disordr patints undrgoing pdiatric dntistry car: an obsrvational and xprimntal study aimd at an innovativ, tailord approach in spcialnds patints Istituto Suprior di Sanita' Clinicoassistnzial Halthcar Dlivry and Mthodologis 28, A nw organizational modl for th managmnt of th diabtic foot ulcrs Sicilia Clinicoassistnzial Halthcar Dlivry and Mthodologis Nw Halthcar Nano/Micromatrials for Paint and Floors Coatings Istituto Suprior di Sanita' Biomdica Bionginring Scincs and Tchnologis COMPARATIVE EFFICACY OF OMOLOGOUS BLOOD BASED EYEDROPS FROM DIFFERENT SOURCES IN THE TREATMENT OF SEVERE KERATOPATHY A RANDOMIZED CLINICAL TRIAL Emilia Romagna Clinicoassistnzial Vascular and Hmatology Sdation Practics in Intnsiv Car Evaluation: Early Goal Dirctd Sdation Compard with Standard Car in Mchanically Vntilatd Patints in Intnsiv Car SAN RAFFAELE MILANO Biomdica Cardiovascular and Rspiratory Scincs A SYSTEMYC APPROACH TO ENSURE THE SAFETY OF SICILIAN FOOD PRODUCTS IZSSI Biomdica Vtrinary Molcular scrning for a prsonalizd tratmnt approach in hpatocllular carcinoma. Campania Biomdica Oncology 1 Basic Translational Pagina 222 di 228

223 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Modulation of microrna profils in modls of cliac disas by toxic and immunomodulatory gliadin pptids : potntial thraputic implication for cliac disas Istituto Suprior di Sanita' Biomdica Digstiv, Kidny and Urological Systms 29, Dvlopmnt of nw laboratory approachs to idntify immunological markrs in th ovin uddr and milk during infction and vaccination against contagious agalactia. IZSSI Biomdica Vtrinary 29, Us of agricultural by products as fd supplmnt for prvntion of Campylobactriosis IZSME Biomdica Vtrinary 29, Effcts of continuous and intrmittnt hypoxia on Oncognsis Puglia Clinicoassistnzial Intrdisciplinary Molcular Scincs and Training 29, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Optimization of cardiac stm cll rplicativ capacity in prclinical and clinical modls of ischmic cardiomyopathy. SAN RAFFAELE PISANA Biomdica Cardiovascular and Rspiratory Scincs 29, Intgration of information sourcs (administrativ and txtual databass plus clinical rgistris) into modls for quality valuation, outcom analysis, tchnology and conomic assssmnt, and support for clinical dcision and halthcar planning focus Lombardia Clinicoassistnzial Risk, Prvntion and Halth Bhavior Pagina 223 di 228

224 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Prclinical assssmnt of th radiosnsitizing activity of NEDD8 pathway inhibition in rctal cancr Istituto Oncologico Candiolo Biomdica EFFECTIVENESS OF 3D ULTRASOUND GUIDED SURGERY IN IMPROVING PATIENTS CLINICAL OUTCOME AND SURVIVAL IN BRAIN TUMOURS SAN RAFFAELE MILANO Clinicoassistnzial Brain Disordrs and Nuroscinc RISK FACTORS FOR INVASIVE CANDIDIASIS IN INTERNAL MEDICINE AND GERIATRIC UNITS Puglia Clinicoassistnzial Infctious Disass and Microbiology Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Capacitiv Coupling Elctric Filds (CCEF) in th Tratmnt of Vrtbral Comprssion Fracturs (VCFs) Puglia Clinicoassistnzial Musculoskltal, Oral and Skin Scincs 30, Escluso dal Finanziamnto pr conflitto con critri bando: Progtto Clinico Assistnzial szion RF GR con richista fondi al Ministro suprior al 50% dl total progtto Ultrasound on bioffcts and safty: an intgratd approach in valuating ultrasound mdiatdcll altrations at both cll mmbran and gntic lvl INAIL Biomdica Cll Biology 30, Pagina 224 di 228

225 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not COmparativ Rsarch of Diffrnt Antithrombotic Stratgis in patints with acut coronary syndrom without prsistnt ST lvation, undrgoing coronary rvascularization (CORDAS Projct): outcoms rsarch and fficacysafty data. Emilia Romagna Clinicoassistnzial Cardiovascular and Rspiratory Scincs 30, Mditrranan plants for Human and a Sustainabl Livstock Halth car IZSSI Biomdica Vtrinary 30, Cognitiv impairmnt in Nurodvlopmnt Disordrs and in arly onst Multipl Sclrosis: sarching for distinctiv/common pathognic insights and prdictiv biomarkrs of clinical cours Puglia Biomdica Brain Disordrs and Nuroscinc Dvlopmnt of a nw diagnostic tool, in th fild of in vivo clinical imaging, basd on a hybrid tchnology consisting of a combination btwn optical contrast (lasr) and ultrasound imaging. Campania Biomdica Surgical Scincs, Biomdical Imaging, and Bionginring 31, A nw approach for prvntion of nosocomial infctions: dvlopmnt of advancd protocols and guidlins for intgratd survillanc procdurs basd on molcular monitoring of ndoscops and rusabl dvics. Campania Biomdica Infctious Disass and Microbiology INCIDENCE OF OSTEONECROSIS OF THE JAW IN PATIENTS IN THERAPY WITH DENOSUMAB AND ANTIANGIOGENIC DRUGS: AN OBSERVATIONAL STUDY SAN MATTEO Clinicoassistnzial Pagina 225 di 228

226 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Authnticity of oliv oil: Paramtrs and innovativ mthods to prsrv th originality of Italian products IZSSI Biomdica Vtrinary Dsign of innovativ composit biomatrials using transglutaminasmdiatd cross links for bon tissu rgnration and possibl applications for thrapy. Sicilia Biomdica Bionginring Scincs and Tchnologis 32, THE IMPACT OF SONICATION ON INFECTION DIAGNOSIS AND TREATMENT. SAN MATTEO Clinicoassistnzial Infctious Disass and Microbiology Effctivnss and cost/ffctiv solutions for non slf sufficint popl SANTA LUCIA Clinicoassistnzial Brain Disordrs and Nuroscinc FOLLOW UP OF NEOPLASTIC CASES IN SENTINEL ANIMALS LIVING IN THE TERRITORY SO CALLED TERRA DEI FUOCHI IN CAMPANIA REGION IZSME Biomdica Oncology 1 Basic Translational Strotactic body radiation thrapy (SBRT) with th Tomothrapy platform in primary and mtastatic lung and livr tumor Sicilia Clinicoassistnzial 34, Th Pharmacomtrics for NuroBlastoma (P4NB) Projct: Intgratd Systms Biology and Quantitativ Analyss to Guid Prsonalizd Tratmnt and Orphan Drug Dvlopmnt in High Risk NB GASLINI Biomdica Pagina 226 di 228

227 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Th rol of 3TMRI HIFU in th priostal nurolysis of th productiv lytic bon mtastats CROB Clinicoassistnzial Rsarch projct for idntification and valuation of a nw tchnical and organizational modl abl to nsur complianc with suspnsion tim aftr slaughtr in livstock in trms of Pharmacosurvillanc, using a systm dvlopd in wb tchnology and hig Lazio Biomdica Vtrinary 35, Early discharg and rmot managmnt of hart failur patint at "Policlinico Casilino" Lazio Clinicoassistnzial Halthcar Dlivry and Mthodologis 35, Assssmnt and rmdiation of cognitiv functions and communicativ abilitis in traumatic brain injurd patints. Bhavioral improvmnt and crbral changs in functional brain connctivity. Pimont Clinicoassistnzial Biobhavioral and Bhavioral Procsss Counslling and Srvic Dlivry program to incras th adhrnc to Mditrranan Dit and to rduc th risk of cardiovascular disas Emilia Romagna Clinicoassistnzial Risk, Prvntion and Halth Bhavior 39, PROJECT TITLE: ArmòniaRsarchaction of work rlatd strss and psychosocial risk assssmnt in a Halthcar Enstablismnt Sicilia Clinicoassistnzial Risk, Prvntion and Halth Bhavior 39, Pagina 227 di 228

228 Tipologia Classificazion 1 Budgt Richisto Finanziamnto Not Rsarch, dsign, analysis, dvlopmnt, tst and tuning of a wb basd informatic systm vn usd on Tablt Android to support and coordinat all activitis of inspction, monitoring and sampling aimd at improvmnt of data xchang with Local Halth A Emilia Romagna Biomdica Vtrinary Rsarch projct on Colony Collaps Disordr on apiaris basd on th storag into a singl rgional databas of all rsults of sampling and information rgistris, halth car and gorfrncd positions, using wb tchnologis and accssd vn by tabl Lazio Biomdica Vtrinary Pagina 228 di 228