1 Introduction to Anatomy and Physiology: Tissues and Integumentary System Biology 105 Lecture 7 Chapter 4
2 Outline I. Tissues A. Epithelial B. Connective C. Muscle D. Nervous tissues II. Cell-to-cell contact III. Body cavities IV. Membranes V. Homeostasis VI. Integumentary System Includes: skin, hair, nails
4 Organization of the Human Body Multicellular organisms require specialized cells to perform specific tasks. These cells then organize into tissues, organs, and organ systems.
5 Tissues A tissue is a group of cells that work together to accomplish a common function. There are four primary tissue types: 1. Epithelial tissue 2. Connective tissue 3. Muscle tissue 4. Nervous tissue
6 Tissues Epithelial tissue covers the body surfaces, lines cavities and organs, and forms glands. Connective tissue binds and supports the body, provides protection for our organs, serves as a storage site for fat, and participates in immunity. Muscle tissue is responsible for movement. Nervous tissue receives stimuli and conducts nerve impulses.
7 Epithelial Tissue Epithelial tissues (epithelium) cover surfaces such as the outside of the body (our skin), as well as line internal cavities and tubes and the inside surface of the stomach and the lungs. Serves for protection, secretion and absorption, and may contain glands. Cells are tightly packed together.
8 Epithelial Tissue All epithelial tissues share two characteristics: 1. A free surface that may be specialized for protection, secretion, or absorption 2. A basement membrane, which binds the epithelial cells to underlying connective tissue
9 Epithelial Tissue - Shapes The three basic shapes of epithelial cells: 1. Squamous epithelium 2. Cuboidal epithelium 3. Columnar epithelium
10 Types of Epithelial Tissue Simple epithelial a single layer of cells classified according to cell type. Stratified epithelial two or more layers of cells, with one on top of the other. Pseudostratified epithelial looks like it has more than one layer, but really does not. Glandular epithelial secretes products like mucus, digestive enzymes, and hormones.
11 Simple Squamous Epithelium Simple squamous epithelium one layer of flattened cells Forms the lining of blood vessels and air sacs in lungs (= alveoli). Functions: exchange of nutrients, waste and gases, and protection
12 Simple Squamous Epithelium Simple Squamous One layer of flattened cells Located in air sacs of lungs, and forms the lining of the heart and blood vessels Allows exchange of nutrients, gases, and wastes Figure 4.1 (1 of 6)
13 Stratified Squamous Epithelium Several layers of flattened cells Located on surface of skin, and lining of mouth, esophagus, and vagina Functions: provides protection against abrasion, infection, and drying out
14 Stratified Squamous Epithelium Stratified Squamous Several layers of flattened cells Located on surface of skin, and lining of mouth, esophagus, and vagina Provides protection against abrasion, infection, and drying out Figure 4.1 (4 of 6)
15 Simple Cuboidal Epithelium Simple cuboidal epithelium one layer of cube-shaped cells Lines the kidney tubules, ovaries, and glands Functions: secretion and absorption
16 Simple Cuboidal Epithelium Simple Cuboidal One layer of cube-shaped cells Located in linings of kidney tubules and glands Functions in absorption and secretion Figure 4.1 (2 of 6)
17 Stratified Cuboidal Epithelium Stratified cuboidal epithelium more than one layer of cube-shaped cells Located in ducts of mammary glands, sweat glands, and salivary glands Functions: protection
18 Stratified Cuboidal Epithelium STRATIFIED EPITHELIUM Stratified Cuboidal Usually two layers of cube-shaped cells Located in ducts of mammary glands, sweat glands, and salivary glands Functions in protection Figure 4.1 (5 of 6)
19 Simple Columnar Epithelium Simple columnar epithelium one layer of rectangular cells Lines the digestive tract, respiratory tract, and the uterus Functions: absorption and secretion
20 Simple Columnar Epithelium SIMPLE EPITHELIUM Simple Columnar One layer of tall, slender cells Located in lining of gut and respiratory tract Functions in absorption and secretion Figure 4.1 (3 of 6)
21 Pseudostratified Ciliated Columnar Epithelium Pseudostratified ciliated columnar epithelium looks like it has more than one layer, but it does not Lines respiratory tract. Function: removes debris from the lungs
22 Stratified Columnar Epithelium Stratifed columnar epithelium more than one layer of rectangular cells Location (rare!): urethra, and junction of esophagus and stomach Functions: protection and secretion
23 Stratified Columnar Epithelium STRATIFIED EPITHELIUM Stratified Columnar Several layers of tall, slender cells Rare: located in urethra (tube through which urine leaves the body) Functions in protection and secretion Figure 4.1 (6 of 6)
24 Tissue Specialization Location Simple squamous Simple cuboidal Simple columnar Pseudostratified Diffusion Absorption and secretion Absorption and secretion Removing debris Alveoli and blood vessels Kidney tubules, ovaries, and glands Digestive tract, respiratory tract, and uterus Respiratory tract
25 Tissue Specialization Location Stratified squamous Stratified cuboidal Stratified columnar Protection Protection Protection and secretion Skin, mouth, esophagus, vagina Ducts of mammary, sweat, and salivary glands Urethra, junction of esophagus and stomach
26 Table 4.1 Epithelial Tissues Table 4.1
27 Glands Glands are composed of epithelial tissue. Exocrine glands secrete their products into ducts. Endocrine glands secrete their products directly into blood.
28 Which of the following is a location where you would find simple cuboidal epithelium? 1. Blood vessels 2. Uterus 3. Kidneys 4. Digestive tract 25% 25% 25% 25% Blood vessels Uterus Kidneys Digestive tract
29 Connective Tissue Connective tissues stabilize, bind, and support other tissues. Cells in connective tissue are usually separated from each other by extracellular material (examples: fibers, carbohydrates). The connective tissue cells secrete this extracellular material.
30 Connective Tissue Many different types of connective tissue: 1. Areolar 2. Adipose 3. Dense (tendons and ligaments) 4. Cartilage 5. Bone 6. Blood
31 1. Loose Areolar Connective Tissue Cells: fibroblasts Fibroblasts secrete protein fibers Functions bind and support Locations under skin, around organs, between muscles
32 Cells = fibroblasts
33 2. Loose Adipose Connective Tissue Cells: adipose cells Stores triglycerides Functions energy storage, insulation, cushioning for organs Locations under skin, and around kidneys and heart
34 Loose Adipose Tissue Adipose (Fat) Tissue Found under skin, around kidneys and heart Functions in energy storage and insulation; provides cushioning for organs Figure 4.2 (2 of 6)
35 3. Dense Connective Tissue Cells: fibroblasts Functions: attaches bone to bone (ligaments), and attaches muscle to bone (tendons) Locations tendons and ligaments
36 Dense Connective Tissue Dense Connective Tissue Found in tendons and ligaments Forms strong bands that attach bone to muscle or bone to bone Figure 4.2 (3 of 6)
37 4. Cartilage (Specialized Connective Tissue) Cells: chondrocytes Cells are located in chambers = lacunae Lacunae are surrounded by a matrix: This type of tissue is strong but flexible. Functions: support and protection (cushioning) Locations: nose, ends of long bones, ribs, in joints, outer ear, and between the vertebrae in the backbone There is not a direct blood supply, so this type of tissue heals slowly.
39 5. Bone (Specialized Connective Tissue) Bone cells: osteocytes Cells are found in lacunae. Rigid connective tissue. Made of hard matrix (provides strength), and protein fibers including collagen (provide strength and flexibility) Functions: 1. Protects and supports internal structures 2. Facilitates movement along with the muscles 3. Stores lipids, calcium, and phosphorus 4. Produces blood cells
41 Bone SPECIALIZED CONNECTIVE TISSUE Bone Found in the skeleton Functions in support, protection (by enclosing organs), and movement Figure 4.2 (5 of 6)
42 6. Blood (Specialized Connective Tissue) Blood consists of liquid (plasma) and formed elements including: Red Blood Cells (RBC) transport oxygen to body cells White Blood Cells (WBC) fight infection Platelets cell fragments necessary for blood clotting.
43 Blood Blood Found within blood vessels Transports nutrients, gases, hormones, wastes; fights infections Figure 4.2 (6 of 6)
44 Connective Tissue Table 4.2
45 Which cells are found in dense connective tissue? 1. Chondrocytes 2. Osteocytes 3. Fibroblasts 4. Osteoblasts 25% 25% 25% 25% Chondrocytes Osteocytes Fibroblasts Osteoblasts
46 Muscle Tissue Muscle tissue can contract and shorten There are three types of muscle tissue that vary in structure, location, and control mechanisms: 1. Skeletal 2. Cardiac 3. Smooth
47 Skeletal Muscle Tissue Location: attached to bones Type of Control: under voluntary control
48 Skeletal Muscle Tissue Nucleus Striation Width of one muscle cell Skeletal Muscle Long cylindrical striated cells with many nuclei Voluntary contraction Most are found attached to the skeleton Responsible for voluntary movement Figure 4.3 (1 of 3)
49 Cardiac Muscle Tissue Location: walls of the heart Type of Control: under involuntary control
50 Cardiac Muscle Tissue Striation Specialized Nucleus junction Cardiac Muscle Branching striated cells with one nucleus Involuntary contraction Found in wall of heart Pumps blood through the body Figure 4.3 (2 of 3)
51 Smooth Muscle Tissue Locations: surrounds other organs and structures (examples: blood vessels, digestive system, lungs) Type of Control: under involuntary control
52 Smooth Muscle Tissue Nucleus Smooth muscle cell Smooth Muscle Cells tapered at each end with one nucleus Involuntary contraction Found in walls of hollow internal organs such as the intestines, and tubes such as blood vessels Contractions in digestive system move food along When arranged in circle, controls diameter of tube Figure 4.3 (6 of 6)
53 Muscle Tissue Table 4.3
54 This type of muscle is under voluntary control: 1. Skeletal 2. Smooth 3. Cardiac 33% 33% 33% Skeletal Smooth Cardiac
55 Nervous Tissue Nervous tissue: Consists of neurons and neuroglia Neurons nerve cells that conduct the message Neuroglia cells that support neurons Makes up the brain, spinal cord, and nerves Functions conducts messages throughout the body
57 Cell Junctions The cells that make up tissues are held together by three types of junctions: 1. Tight junctions 2. Adhesion junctions 3. Gap junctions
58 Tight Junctions Function prevent substances from leaking across tissues Locations urinary and digestive tracts
59 Tight Junctions Creates an impermeable junction that prevents the exchange of materials between cells Found between epithelial cells of the digestive tract, where they prevent digestive enzymes and microorganisms from entering the blood Plasma membrane Intercellular space Tight junction protein Basement membrane Connective tissue Figure 4.5a
60 Adhesion Junctions Function holds adjacent cells together and allows tissues to be flexible Locations skin, and opening of the uterus
61 Adhesion Junctions Holds cells together despite stretching Found in tissues that are often stretched, such as the skin and the opening of the uterus Intercellular space Figure 4.5b
62 Gap Junctions Function open channels between cells allowing rapid communication due to quick transfer of ions and small molecules between neighboring cells Locations heart and smooth muscle
63 Gap Junctions Allows cells to communicate by allowing small molecules and ions to pass from cell to cell Found in epithelia where the movement of ions coordinates functions, such as the beating of cilia Found in excitable tissue, such as heart and smooth muscle Protein channels Intercellular space Figure 4.5c
64 Which junction allows rapid communication between neighboring cells? 1. Tight 2. Adhering 3. Gap 33% 33% 33% Tight Adhering Gap
65 Which junction prevent substances from leaking across tissues? 1. Tight 2. Adhering 3. Gap 33% 33% 33% Tight Adhering Gap
66 Body Cavities We have two main body cavities: Dorsal cavity (posterior) Ventral cavity (anterior)
68 Ventral Body Cavity The ventral cavity is divided into two cavities: Thoracic cavity The thoracic cavity is further subdivided into: Pleural cavities contains lungs Pericardial cavity contains heart Abdominal cavity The abdominal cavity contains the digestive system, the urinary system, and the reproductive system. The diaphragm is a broad sheet of muscle that divides the two cavities.
69 Body Cavities Thoracic cavity Pleural cavity contains a lung Pericardial cavity contains heart Ventral cavity Thoracic cavity Diaphragm Abdominal cavity Figure 4.6 (1 of 6)
70 Dorsal Cavity The dorsal cavity is divided into two cavities: Cranial contains brain Spinal contains spinal cord
71 Body Cavities Dorsal cavity Cranial cavity contains brain Spinal cavity contains spinal cord Vertebra Figure 4.6 (2 of 2)
72 The arrow is pointing to the: 1. Cranial 2. Thoracic 3. Abdominopelvic 33% 33% 33% Cranial Thoracic Abdominopelvic
73 The arrow is pointing to the: 1. Cranial 2. Thoracic 3. Abdominopelvic 33% 33% 33% Cranial Thoracic Abdominopelvic
74 The arrow is pointing to the: 1. Pleural 2. Pericardial 50% 50% Pleural Pericardial
75 Membranes Body cavities and surfaces of organs are covered with membranes. Membranes are sheets of epithelium supported by connective tissues. Membranes protect tissues and organs.
76 Membranes There are four types of membranes: 1. Mucous 2. Serous 3. Synovial 4. Cutaneous
77 Mucous Membranes Mucous line passages to the exterior world, including those of the respiratory, digestive, reproductive, and urinary systems in the body Secrete mucus
78 Serous Membranes Serous line thoracic and abdominopelvic cavities and the organs contained in them Secrete lubricating fluid
79 Synovial Membranes Synovial line cavities of freely movable joints Secrete a lubricating fluid
80 Cutaneous Membranes Cutaneous skin, lines the outside of the body (thick and dry)
81 Organs and Organ System An organ is a group of tissues that work together to perform a specific function. In turn, organs work together to form an organ system.
82 Example Organ: Stomach 1. Epithelium lines the stomach and secretes acid to digest the food. 2. Nervous tissue stimulates cells to release the acid. 3. Muscles contract to push food through the stomach. 4. Connective tissue supports these other tissues.
84 Remember Homeostasis?!? Homeostasis the ability to maintain a relatively stable environment in the body How does the body accomplish this daunting task?!?
85 Feedback The body uses the nervous system and the endocrine systems to maintain homeostasis. Controlled by negative or positive feedback
86 Feedback Figure 4.12
87 Feedback Mechanism A sensor/receptor detects a change (= stimulus) in the internal or external environment. A control center, such as a part of the brain, integrates the information coming from all receptors and sends out an appropriate response. The effector carries out the response, returning the system to homeostasis again.
88 Hormones Hormone a substance released into the blood that carries a message to other parts of the body. When hormones are released from one part of the body, they cause another part of the body to react.
89 Feedback In general, Negative Feedback is used to keep the body in balance, and it maintains the status quo. Positive Feedback is used to change the situation.
90 Negative Feedback Example: Calcium Example: calcium regulation Calcium is stored in the bones and circulates in the blood stream. Cells in the bones, osteoclasts, release calcium from bone.
91 Negative Feedback Example: Calcium Stimulus: calcium levels drop too low in the blood stream Sensor/receptor: parathyroid glands Control center: the parathyroid gland releases parathyroid hormone Effectors: osteoclast cells in bone release calcium and the kidneys reabsorb more calcium
92 Negative Feedback Example: Calcium Stimulus: calcium levels increase too high in the blood stream Sensor/receptor: parathyroid glands Control center: the parathyroid gland stops releasing parathyroid hormone Effectors: osteoclast cells in bone stop releasing calcium and the kidneys reabsorb less calcium
93 Negative Feedback Example: Temperature Read pages 79-81: temperature regulation in the body Hyperthermia: abnormally elevated body temperature Hypothermia: abnormally low body temperature The thermostat for the body is located in the hypothalamus.
94 Positive Feedback Example: Childbirth Stimulus: when the baby leaves the uterus, the muscles in the cervix stretch. Nerves in the cervix send a message to the hypothalamus gland. Sensor/receptor: stretch receptors in the cervix Control Center: hypothalamus gland causes the pituitary gland to release oxytocin Effector : muscles of uterus contract
95 Positive Feedback Example: Childbirth More pressure stimulates the stretch receptors, which signal the hypothalamus to tell the pituitary gland to release more oxytocin.
96 Integumentary System Components of the integumentary system: Skin Nails Hair Exocrine glands (sweat and oil glands)
97 Integumentary System Functions 1. Provides protection from bacteria, UV radiation, chemicals, physical injury 2. Reduces water loss 3. Temperature regulation 4. Vitamin D production 5. Contains sensors that detect pain, temperature, and pressure
98 Skin Layers The skin has two layers: 1. Epidermis thin outer layer of stratified squamous epithelial tissue 2. Dermis thick underlying layer of mainly connective tissue
101 Epidermis Epidermis consists of several layers of squamous epithelial cells (stratified). Deepest layer contains rapidly dividing cells. Outer surface is made up of dead skin cells. Protective properties come from keratin. Melanocytes produce melanin.
102 Dermis The dermis consists primarily of connective tissue. Also contains vascular tissue, hair follicles, sweat glands, nerves, and sensory receptors Collagen and elastic fibers are found in the lower layer, which allows the skin to stretch and return to its original shape.
103 Hypodermis The hypodermis is a layer of loose connective tissue beneath the dermis and epidermis, connecting them to other tissues. The hypodermis is not a part of the skin it lays underneath the skin.
104 Accessory Organs of the Skin Nails - sheets of hard keratinized cells forming a protective covering for the fingers and toes. Hair follicles - found in the dermis and where sebum is released to lubricate the hair. Sweat glands - play a role in modifying body temperature and have ducts that lead to a pore at the surface of the skin. Sebaceous glands - secrete sebum, an oily substance that lubricates the skin and hair.
105 Skin Cancer Melanin protects against UV radiation. Three types of skin cancer: 1. Basal cell carcinoma from rapidly dividing cells deep in the epidermis 2. Squamous cell carcinoma from newly formed cells as they flatten 3. Melanoma from melanocytes; far more dangerous than other skin cancers and more likely to spread to other body parts
106 Figure 4.A Three skin cancers
107 Melanoma in the United States 2005 Estimates Ref: the American Cancer Society New Cases 59,600 Deaths Per Year 7,800 5-Year Overall Survival Rate 91% 5-Year Localized Survival Rate 98% 5-Year regional Survival Rate 60% 5-Year distant Survival Rate 14%
108 These cells found in skin produce pigments: 1. Chondrocytes 2. Melanocytes 3. Fibroblasts 4. Osteocytes 25% 25% 25% 25% Chondrocytes Melanocytes Fibroblasts Osteocytes
109 Important Concepts Read chapter 4 What are the four tissue types, their functions, and examples of each type? What are examples, functions, and locations of each of the types of connective tissue? Why does it take longer for cartilage to heal? What cell types are found in each type of connective tissue?
110 Important Concepts What are the functions of red blood cells, white blood cells, and platelets? What are the three types of muscle? What are their functions, and where they are found? Are they under voluntary or involuntary control? What are the two types of nervous tissue cells and their functions? What are the types of epithelial tissue, where are they found, and what are their functions?
111 Important Concepts What are the two types of glands? How do negative and positive feedback mechanisms work? Be able to describe the examples of negative and positive feedback given in class and in the textbook (e.g. identify the sensor, control center, and effector for each example). What are the three cell-to-cell junctions and their functions?
112 Important Concepts Identify the body cavities: what are their locations and what is contained in each of the cavities? What are the four types of membranes, their functions and locations? What are the functions of the integumentary system? Components of the integumentary system and their functions
113 Important Concepts What are the two layers of the skin? Which type of tissues comprise each layer, and where are the layers located? What layer is found underneath the skin, and which tissue type comprises this layer? What are the three types of skin cancer, where do they originate, and which is more likely to spread to other parts of the body? What are melanocytes, and what is their function?
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Human Body Systems Project By Eva McLanahan Students will work in groups to research one of the eleven body systems as found in Holt, Rinehart, and Winston Modern Biology (2002). Research will focus on
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67 The Human Skeleton Skull SCIENCE EXPLORER Focus on Life Science Prentice-Hall, Inc. Clavicle (collarbone) Scapula (shoulder blade) Carpals Metacarpals Phalanges Femur Tibia Humerus Ulna Sternum (breastbone)
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Structure & Function Introduction Prof Kumlesh K. Dev Department of Physiology What is Structure & Function? Integration is key structure and function requires integration of physiology, anatomy and biochemistry
Skeletal System Chapter 11 11.1 Overview of the skeletal system What are the functions of the skeletal system? 1. Supports the body 2. Protects the soft body parts 3. Produces blood cells 4. Stores minerals
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Endocrine System: Practice Questions #1 1. Removing part of gland D would most likely result in A. a decrease in the secretions of other glands B. a decrease in the blood calcium level C. an increase in