Advances in B Cell Biology:

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1 R.J. Fasenmyer Center for Clinical Immunology and Phoenix Rheumatology Association Advances in B Cell Biology: RA, SLE, and Vasculitis Saturday, February 18, 2012 Gainey Ranch Golf Club Scottsdale, AZ Register Today!

2 ADVANCES IN B CELL BIOLOGY: RA, SLE, AND VASCULITIS OVERVIEW Recent research efforts have increasingly focused on the efficacy, utility, and safety of B cell-targeted therapies for autoimmune rheumatic diseases (ARDs) including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and vasculitis. The increasing adoption of these targeted biologic agents into clinical practice challenges clinicians to remain informed regarding data from new and ongoing research studies and clinical trials, especially those presented at national and international meetings. Advances in B Cell Biology: RA, SLE, and Vasculitis is a CME-accredited activity in which expert faculty bridge the gap between the complexities of current immunologic data and how they can be incorporated into clinical practice. It is designed for busy clinicians interested in keeping abreast of cutting-edge data and novel therapies in treatment of ARDs information that can have significant positive impacts on patient outcomes. TARGET AUDIENCE This symposium is directed to rheumatologists, immunologists, allied health professionals, and other health care professionals interested in rheumatic diseases. LEARNING OBJECTIVES As a result of attending this symposium, the participant will be able to do the following: Summarize recent findings on B cell biology as they apply to understanding the pathophysiology of autoimmune and inflammatory diseases and describe how this knowledge has influenced the development of new and innovative therapeutics utilizing these pathways; Describe recent clinical trial data on the efficacy and safety of biologic therapeutics targeting B cell pathways in patients with RA; Describe the role of B cells in the pathogenesis of SLE and assess data from recent clinical trials of biologic therapeutics that target these pathways; Describe the role of B cells in the pathogenesis of systemic vasculitis and appraise recent clinical trial data on the efficacy and toxicity of traditional and biologic therapies. ACCREDITATION The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Cleveland Clinic Foundation Center for Continuing Education designates this live activity for a maximum of 3.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit.

3 ACTIVITY DIRECTORS Leonard Calabrese, DO Cleveland Clinic Lerner College of Medicine of Case Western Reserve University R.J. Fasenmyer Chair of Clinical Immunology Vice Chairman Department of Rheumatic and Immunologic Diseases Orthopaedic and Rheumatologic Institute Cleveland Clinic Cleveland, OH Gregg J. Silverman, MD Co-Director Musculoskeletal Center New York University School of Medicine Smilow Research Center New York, NY FACULTY Richard Furie, MD Hofstra North Shore LIJ School of Medicine Albert Einstein College of Medicine Chief, Division of Rheumatology and Allergy-Clinical Immunology North Shore-Long Island Jewish Health System Lake Success, NY Jonathan Kay, MD Director of Clinical Research Rheumatology Division University of Massachusetts Medical School Worcester, MA William Rigby, MD Vice-Chair Department of Medicine Microbiology and Immunology Dartmouth Hitchcock Medical Center Lebanon, NH FACULTY DISCLOSURE The Cleveland Clinic Foundation Center for Continuing Education has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus. ACKNOWLEDGEMENTS The Cleveland Clinic Foundation Center for Continuing Education acknowledges educational grants for partial support of this activity from: Genentech and Biogen Idec Human Genome Sciences

4 AGENDA SATURDAY, FEBRUARY 18, :00 am Registration and Continental Breakfast 8:20 am Welcome and Introduction 8:30 am New Perspectives on B Cell Immunobiology and Emerging B Cell Therapies Gregg Silverman, MD 9:15 am Advances in B Cell Therapy for RA William Rigby, MD 9:45 am Advances in B Cell-Directed Therapies in SLE Richard Furie, MD 10:15 am Refreshment Break 10:30 am Emerging Role of B Cell-Directed Therapies for Vasculitis Leonard Calabrese, DO 11:00 am Safety in Biologics Jonathan Kay, MD 11:30 am Advances in B Cell Biology Interactive Case Discussion Panel 12:00 pm Adjourn GENERAL INFORMATION LOCATION Gainey Ranch Golf Club 7600 Gainey Club Drive Scottsdale, AZ Phone: Website: HOTEL ACCOMMODATIONS Gainey Suites Hotel 7300 East Gainey Suites Dr Scottsdale, AZ Phone: A block of rooms has been reserved at the Gainey Suites Hotel. To make your reservations, contact the Hotel Reservations Department at Identify yourself as being with the Advances in B Cells Conference for a special rate of $179 studio king suite; $189 for one bedroom king or queen suite. REGISTRATION Preregistrations are accepted by fax or online until 12:00 pm ET on February 17, Please register onsite after this time. For more information about the symposium, contact the Cleveland Clinic Foundation Center for Continuing Education: Phone: Fax: For questions about registering: Phone: REGISTER TODAY!

5 Registration Form Advances in B Cell Biology: RA, SLE, and Vasculitis Course Office Use Only Fee Date MOP CXL/Fee Registration Fee: COMPLIMENTARY Includes: continental breakfast, refreshment breaks, and syllabus o Physician o Resident/Fellow o Nurse o Nurse Practitioner o Physician Assistant o Other (Specify: ) REGISTER ONLINE If you register online, please do not mail or fax in a registration form. Cleveland Clinic employee registration is available online only. Complete the information below if registering by mail or fax. Please Print Clearly First Name: Last Name: MI: Degree: Company Name: Address: City: State: Zip: Phone Number: Fax Number: Specialty: Address: Practice Type: o Office Based o Hospital Staff o Resident/Fellow o Other Fax: Mailing Address: The Cleveland Clinic Educational Foundation PO Box Cleveland, OH For questions about registering: Phone:

6 R.J. Fasenmyer Center for Clinical Immunology and Phoenix Rheumatology Association Advances in B Cell Biology: RA, SLE, and Vasculitis Saturday, February 18, 2012 Gainey Ranch Golf Club Scottsdale, AZ Register Today! The Cleveland Clinic Foundation Center for Continuing Education 9500 Euclid Avenue, AC313 Cleveland, Ohio NON-PROFIT ORG. U.S. Postage Paid Cleveland, OH Permit No. 1918

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