2011 Waters Corporation

Transcription

1 2011 Waters Corporation Waters Overview

2 Introduction to Waters Established in 1958 Publicly traded corporation (NYSE:WAT) $1.84 billion in annual revenue Headquartered in Milford, Massachusetts Manufacturing and distribution centers worldwide 5,700 employees many of whom were once customers Average of >10 years of service (>16 yrs in the field) > 2,400 sales and service within the field organization maintains direct link with end users Greatest proportion of revenue derived from new products 1.84$B All facilities cgmp-compliant & ISO certified 20,000 instruments 180,000 columns 1,400,000 parts / year 320$M 795$M Waters Corporation 2

3 Breakthrough Technology First liquid separations System GPC-150 High-performance liquid chromatography M6000 HPLC Pump Solid phase Extraction Sep-Pak Cartridges 1988 PC-based Chromatography software Maxima Software 2012 UPC Quadrupole Time-of-flight MS Q-Tof TM Mass Spectrometer 2006 High-Definition MS SYNAPT HDMS TM System 2010 ACQUITY H-class Patrol 2004 First UPLC System ACQUITY UPLC System 2008/2009 XEVO TM TQ MS XEVO QTof MS 2013 Waters Corporation 3

4 Application Focus Pharmaceutical Biopharmaceuticals Chemical/Industrial Environmental Clinical Food Safety 2013 Waters Corporation 4

5 2013 Waters Corporation 5

6 Waters Technologies 2013 Waters Corporation 6

7 Waters Technologies 2013 Waters Corporation 7

8 The ACQUITY Difference Demand for UHPLC systems has continued to outpace demand for other HPLC techniques. UHPLC systems are fast becoming the standard tool for research and routine applications. Strategic Directions International 2013 Waters Corporation 8

9 UPLC: Bridging the Gap From Laboratory to Manufacturing Floor Discovery/ Development Lab QC Lab Process Lab Manufacturing Floor 2013 Waters Corporation 9

10 La più ampia scelta di colonne per UPLC Cinque substrati differenti 130Å, 200Å e 300Å BEH [Ethylene Bridged Hybrid], HSS [High Strength Silica] e CSH [Charged Surface Hybrid] Tutte disponibili per HPLC e UPLC Ampio spettro fasi stazionarie 18 fasi stazionarie BEH 130Å C 18, C 8, Shield RP 18, Phenyl, HILIC ed Amide, IEX BEH 300Å C 18 e C 4 BEH 200Å SEC HSS-C 18, HSS-T3, HSSC 18 -SB, HSS-PFP, HSS-CN CSH C 18, Fluoro-Phenyl e Phenyl-Hexyl Colonne per applicazioni speciali AAA, OST, PST, PrST e Glycan Transferibilità tra HPLC ed UPLC XBridge HPLC = ACQUITY BEH HSS HPLC and= ACQUITY HSS XSelect HPLC = ACQUITY CSH BEH C 18 BEH C 8 BEH Phenyl BEH Shield RP18 BEH HILIC BEH Amide HSS T3 HSS C 18 HSS C 18 SB CSH C 18 CSH Fluoro-Phenyl CSH Phenyl-Hexyl 2013 Waters Corporation 10

11 Evolution of Separation Technology Gas Chromatography Liquid Chromatography Convergence Chromatography GC HPLC SFC Capillary GC UPLC UPC Waters Corporation 11

12 The Advent of Convergence Chromatography SFC UltraPerformance Convergence Chromatography Convergence Chromatography UltraPerformance Convergence Chromatography is the result of significant technological advancements in Supercritical Fluid Chromatography instrumentation and chemistry design while providing exceptional increases in available selectivity Data courtesy of Davy Guillarme, Jean-Luc Veuthey LCAP, University of Geneva, Switzerland 2013 Waters Corporation 12

13 ACQUITY UPC² System Built upon proven UPLC Technology Quantifiable increase in productivity Exceptional increase in available selectivity Solve routine and complex separation challenges 2013 Waters Corporation 13

14 Where is CC Applicable? Pharmaceutical and Life Sciences Metabolite ID, stability-indicating, impurity profiling Purity assessment, final product analysis Chiral Orthogonal method screening (vs. RPLC) Food and environment Vitamins, essential oils, pesticides, lipids, triglycerides, food additives Chemical materials Polymers, organometallics, dyes, petroleum, surfactants, petrochemicals, biodiesel Clinical research Vitamin D metabolites Steroids 2013 Waters Corporation 14

15 Soluzioni MS SQD2 XevoTQD XevoTQ XevoTQ-S Xevo G2 Tof Xevo G2 QTof Synapt G2-S Synapt G2 HDMS 2013 Waters Corporation 15

16 2013 Waters Corporation 16

17 Sessioni 2013 Waters Corporation 17

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19 Grazie 2013 Waters Corporation 19