LC-MS/MS, the new reference method for mycotoxin analysis
|
|
- Pierce Chambers
- 8 years ago
- Views:
Transcription
1 LC-MS/MS, the new reference method for mycotoxin analysis What is necessary for the implementation of the multi-residue mycotoxin method in an analytical laboratory? Azel Swemmer AFMA Conference March 2009
2 Introduction Aspects that will be covered: Analytical processes Requirements for ISO accreditation Manpower, equipment, techniques and QA Detection, quantification of trace level analytes
3 ANALYTICAL PROCESS Sampling Sample Submission Certificate of Analysis Sample Extraction/ Clean-up Data Manipulation Instrumentation
4 Accreditation ISO standard Management requirements (section 4) Technical requirements (section 5) ISO 9001:2008 Method accreditation Large batches, routine matrices Technique accreditation Small batches, non-routine matrices
5 Technical Requirements Skilled manpower Sensitive equipment And methodology An appropriate QA system
6 ANALYTICAL PROCESS Sampling Sample Submission Certificate of Analysis Sample Extraction/ Clean-up Data Manipulation Instrumentation
7
8 ANALYTICAL PROCESS Sampling Sample Submission Certificate of Analysis Sample Extraction/ Clean-up Data Manipulation Instrumentation
9 Extraction and cleanup of the samples Most critical step in the analytical process essential to control this step Selection of; Sub-sample size, Extraction solvents - dependant on the matrix Cleanup step liquid/liquid or SPE or no cleanup? Concentration step to reach detection limits How can we control this step?
10 QA of the extraction step Use of Certified Reference Materials (CRM) Spiking of samples QC samples in batch Participation in proficiency testing schemes
11 SOP must clearly spell out the parameters to control during sample extraction Laboratory temperature ph meter fluctuations Centrifugation speed and time Scale calibration Auto-pipette calibration Grade of solvents/reagents specified in the method
12 ANALYTICAL PROCESS Sampling Sample Submission Certificate of Analysis Sample Extraction/ Clean-up Data Manipulation Instrumentation
13 Sensitivity depends on instrumentation used Potential for interferences MS-MS LC/GC-MS HPLC-F HPLC-UV ELISA Microbiological Ability to discriminate (Price increase)
14 Comparison of different techniques Method of Analysis Thin Layer Chromatography (TLC) Enzyme Linked Immunosorbant Assay (ELISA) High Performance Liquid Chromatography (HPLC) Gas chromatography (GC-MS) LC-MS/MS Costs/ group/sample (Rand) N= Method characteristics High Sensitivity Costs per single group Costs per single group Selected groups e.g. Trichothenescenes All groups
15 Mycotoxin Multi Residue Method The first multi-methods methods were published (Berger et al., Razzazi-Fazeli et al., Rundberget et al.,spanjer et al. etc.) At this time, LC-MS/MS was mainly a scientific approach and a lot of maintenance was necessary to run samples within a broad range of commodities Since the instruments getting more robust, LC-MS/MS has been increasingly applied for routine food control. Today, it seems that they are fit for purpose!
16 Instrumentation LC MS/MS Column oven Solvent delivery module Ion source MS/MS Auto sampler
17 Advantages of LC-MS/MS Sensitive detection for not one; but numerous mycotoxins in a single analysis. Does not require tedious and expensive sample preparation due to sensitive tandem mass spectrometer Results in fast turn around time for client. Currently the method of choice in analytical laboratories.
18 Time scale to perform a batch (12 24) of analyses Samples weighing 1,5 hours Samples are extracted with an extraction solvent 2 hours Samples are cleaned up on a SPE cartridge 3 hours Injection into LC-MS/MS 8 hours Data Analysis 2 hour Report 0.5 hour
19 LC-MS/MS Results. Blank samples Certified reference material at 3.2 ug/kg A) B) Blank feed sample (A) vs naturally contaminated deoxynivalenol wheat sample (B)
20 Quantitation of T2 and HT2 R = R = A B Figure 4: Typical Calibration Curves obtained for T2 Toxin (A) and HT2 Toxin (B). All data is calculated against matrix based calibration curves
21 Analysis performed against certified reference material. Day 1 Day 2 Deoxynivalenol (DON) Added amount (µg/kg) Value obtained (µg/kg) Day 1 Day 2 Aflatoxin B1 Added amount (µg/kg) Value obtained (µg/kg) Day Day Zearalenone Aflatoxin B2 Added amount (µg/kg) Value obtained (µg/kg) Added amount (µg/kg) Value obtained (µg/kg) Day Day Day Day Day Day
22 Conclusions Man-power must be skilled (VERY hard to find in SA) Equipment is expensive Technique accreditation most difficult QA requirements is laborious and difficult to control
23 ANALYTICAL PROCESS Sampling Sample Submission Certificate of Analysis Sample Extraction/ Clean-up Data Manipulation Instrumentation
24 This is our policy to resolve complaints
How To Test For Contamination In Large Volume Water
Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples Keywords Application Note ENV0212 This collaboration study was performed
More informationFast, Reproducible LC-MS/MS Analysis of Dextromethorphan and Dextrorphan
Fast, Reproducible LC-MS/MS Analysis of and Kimberly Phipps, Thermo Fisher Scientific, Runcorn, Cheshire, UK Application Note 685 Key Words Accucore C18, dextromethorphan, dextrorphan, SOLA CX Abstract
More informationCONFIRMATION OF ZOLPIDEM BY LIQUID CHROMATOGRAPHY MASS SPECTROMETRY
CONFIRMATION OF ZOLPIDEM BY LIQUID CHROMATOGRAPHY MASS SPECTROMETRY 9.1 POLICY This test method may be used to confirm the presence of zolpidem (ZOL), with diazepam-d 5 (DZP-d 5 ) internal standard, in
More informationMedical Cannabis Laboratory Approval Program
Medical Cannabis Laboratory Approval Program Application Process and Required Documentation After the publication of the Medical Cannabis Laboratory Application, currently expected by February 16, 2015,
More information2014 AAFCO Check Sample Mycotoxins Program. Samples Engineered to Contain Relevant Concentrations of Significant Mycotoxins.
2014 AAFCO Check Sample Mycotoxins Program Samples Engineered to Contain Relevant Concentrations of Significant Mycotoxins. The Samples Source the base feed. Materials thoroughly processed with regard
More informationPesticide residue analysis: New Trends. Michal Godula, Ph.D. EU Marketing Manager Food Safety & Environmental Thermo Fisher Scientific
Pesticide residue analysis: New Trends Michal Godula, Ph.D. EU Marketing Manager Food Safety & Environmental Thermo Fisher Scientific Why pesticide analysis? Extensively used in agriculture to control
More informationLC-MS/MS Method for the Determination of Docetaxel in Human Serum for Clinical Research
LC-MS/MS Method for the Determination of Docetaxel in Human Serum for Clinical Research J. Jones, J. Denbigh, Thermo Fisher Scientific, Runcorn, Cheshire, UK Application Note 20581 Key Words SPE, SOLA,
More informationLC-MS/MS for Chromatographers
LC-MS/MS for Chromatographers An introduction to the use of LC-MS/MS, with an emphasis on the analysis of drugs in biological matrices LC-MS/MS for Chromatographers An introduction to the use of LC-MS/MS,
More informationHow To Develop A Recipe Card
TSNA Method Development Dr Michael Intorp CORESTA Cooperation Center for Scientific Research Relative to Tobacco FDA Center for Tobacco Products Scientific Workshop Tobacco Product Analysis 30 31 July
More informationS olid Ph ase Extraction (SP E) Method:
Solid Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/ Tandem Mass Spectrometry Toni Hofhine, Horizon Technology,
More informationÁdám Tölgyesi Joerg Stroka. Report EUR 26496 EN
Report on the development of a method for the determination of Alternaria toxins and citrinin in wheat, tomato juice and sunflower seeds by liquid chromatography tandem mass spectrometry Ádám Tölgyesi
More informationEcology Quality Assurance Glossary
Ecology Quality Assurance Glossary Edited by William Kammin, Ecology Quality Assurance Officer Accreditation - A certification process for laboratories, designed to evaluate and document a lab s ability
More informationA commitment to quality and continuous improvement
Guidance for the Validation of Analytical Methodology and Calibration of Equipment used for Testing of Illicit Drugs in Seized Materials and Biological Specimens A commitment to quality and continuous
More informationChemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography
Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography INTRODUCTION The analysis of soft drinks for caffeine was able to be performed using UV-Vis. The complex sample
More informationCORESTA RECOMMENDED METHOD N 72
CORESTA RECOMMENDED METHOD N 72 DETERMINATION OF TOBACCO-SPECIFIC NITROSAMINES IN SMOKELESS TOBACCO PRODUCTS BY LC-MS/MS (February 216). INTRODUCTION The CORESTA Smokeless Tobacco Sub-Group studied various
More informationAutomation of Solid Phase Extraction and Column Chromatographic Cleanup
Automation of Solid Phase Extraction and Column Chromatographic Cleanup Haibin Wan Ltd. Problems with Manual Operation 1. Unstable flow rate affects reproducibility and throughput. 2. Not convenient for
More information# LCMS-35 esquire series. Application of LC/APCI Ion Trap Tandem Mass Spectrometry for the Multiresidue Analysis of Pesticides in Water
Application Notes # LCMS-35 esquire series Application of LC/APCI Ion Trap Tandem Mass Spectrometry for the Multiresidue Analysis of Pesticides in Water An LC-APCI-MS/MS method using an ion trap system
More informationAnalysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS
Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS Stephen Lock 1 and Matthew Noestheden 2 1 AB SCIEX Warrington, Cheshire (UK), 2 AB SCIEX Concord, Ontario (Canada) Overview A rapid,
More informationControl Charts and Trend Analysis for ISO 17025. Speakers: New York State Food Laboratory s Quality Assurance Team
Control Charts and Trend Analysis for ISO 17025 Speakers: New York State Food Laboratory s Quality Assurance Team 1 ISO 17025 Requirements, 5.9.1: The laboratory shall have quality control procedures for
More informationThermo Scientific HyperSep Solid Phase Extraction Method Development Guide
chromatography Thermo Scientific HyperSep Solid Phase Extraction Method Development Guide The following guide provides considerations, tips and general guidelines for developing SPE methods using the Thermo
More informationMultiQuant Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples
MultiQuant Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples Fast and Efficient Data Review, with Automatic Flagging of Outlier Results Adrian M. Taylor and Michael
More informationNUVISAN Pharma Services
NUVISAN Pharma Services CESI MS Now available! 1st CRO in Europe! At the highest levels of quality. LABORATORY SERVICES Equipment update STATE OF THE ART AT NUVISAN CESI MS Now available! 1st CRO in Europe!
More informationSIMULTANEOUS DETERMINATION OF NALTREXONE AND 6- -NALTREXOL IN SERUM BY HPLC
SIMULTANEOUS DETERMINATION OF NALTREXONE AND 6- -NALTREXOL IN SERUM BY HPLC Katja SÄRKKÄ, Kari ARINIEMI, Pirjo LILLSUNDE Laboratory of Substance Abuse, National Public Health Institute Manerheimintie,
More informationApplication Note # LCMS-62 Walk-Up Ion Trap Mass Spectrometer System in a Multi-User Environment Using Compass OpenAccess Software
Application Note # LCMS-62 Walk-Up Ion Trap Mass Spectrometer System in a Multi-User Environment Using Compass OpenAccess Software Abstract Presented here is a case study of a walk-up liquid chromatography
More informationThermo Scientific Prelude SPLC System FPO. Making LC/MS accessible. to clinical research and toxicology labs
Thermo Scientific Prelude SPLC System FPO Making LC/MS accessible to clinical research and toxicology labs Specifically designed to make the power of LC/MS accessible Analysis of target compounds in complex
More informationImproving mycotoxins measurements by combining rapid analysis with dust sampling
Improving mycotoxins measurements by combining rapid analysis with dust sampling Project presentation Dr. Scarlett Biselli, Mareike Reichel Mycotoxin Forum 5-6.09.13, Brussel www.eurofins.de Dust Sampling
More informationOptimizing the Post-implementation Monitoring of a LC-MS/MS Method
Optimizing the Post-implementation Monitoring of a LC-MS/MS Method Julianne Cook Botelho, PhD Centers for Disease Control and Prevention Atlanta, GA AACC- Mass Spectrometry in the Clinical Lab: Best Practice
More informationDetermination of Anabolic Steroids in Horse Urine by SPE and LC-MS/MS
Summary: Determination of Anabolic Steroids in Horse Urine by SPE and LC-MS/MS UCT Part Numbers: CUNAX226 - Clean-Up C8+NAX, 2mg/6mL BETA-GLUC- ml Beta-Glucuronidase Enzyme, liquid form SLAQ1ID21-3UM -
More informationQuantitative analysis of anabolic steroids in control samples from food-producing animals using a column-switching LC-HESI-MS/MS assay
PO-CON1484E Quantitative analysis of anabolic steroids in control samples from food-producing animals using a column-switching ASMS 014 TP85 David R. Baker 1, John Warrander 1, Neil Loftus 1, Simon Hird
More informationFOOD FOR THOUGHT Topical Insights from our Subject Matter Experts UNDERSTANDING WHAT IS NEEDED TO PRODUCE QUALITY DATA
FOOD FOR THOUGHT Topical Insights from our Subject Matter Experts UNDERSTANDING WHAT IS NEEDED TO PRODUCE QUALITY DATA The NFL White Paper Series Volume 7, January 2013 Overview and a Scenario With so
More informationMaking the Leap to LC/MS/MS: Enhancing and Accelerating Clinical Research and Forensic Toxicology Applications
TECHNICAL NOTE Toxicology Making the Leap to LC/MS/MS: Enhancing and Accelerating Clinical Research and Forensic Toxicology Applications Introduction The resolving power of chromatography combined with
More informationVitamin B 12 - A review of analytical methods for use in food. Government Chemist Programme Report
Vitamin B 12 - A review of analytical methods for use in food Government Chemist Programme Report March 2015 Vitamin B12 - A review of analytical methods for use in food Author: Paul Lawrance Contact point:
More informationA High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS
A High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS AB SCIEX QTRAP 4500 LC/MS/MS System and Gerstel, Inc. MultiPurpose Sampler
More informationOverview. Purpose. Methods. Results
A ovel Approach to Quantify Unbound Cisplatin, Carboplatin, and xaliplatin in Human Plasma Ultrafiltrate by Measuring Platinum-DDTC Complex Using LC/M/M Min Meng, Ryan Kuntz, Al Fontanet, and Patrick K.
More informationMaking the Leap to LC/MS/MS: Enhancing and Accelerating Clinical Research and Forensic Toxicology Applications
Making the Leap to LC/MS/MS: Enhancing and Accelerating Clinical Research and Forensic Toxicology Applications Introduction The resolving power of chromatography combined with the sensitivity and selectivity
More informationGuidance for Industry
Guidance for Industry Q2B Validation of Analytical Procedures: Methodology November 1996 ICH Guidance for Industry Q2B Validation of Analytical Procedures: Methodology Additional copies are available from:
More informationSPE, LC-MS/MS Method for the Determination of Ethinyl Estradiol from Human Plasma
SPE, LC-MS/MS Method for the Determination of Ethinyl Estradiol from uman Plasma Krishna Rao Dara, Dr. Tushar N. Mehta, Asia Pacific Center of Excellence, Thermo Fisher Scientific, Ahmedabad, India Application
More informationSimultaneous Qualitative and Quantitative Data Acquisition for Research of Diabetes Drugs
Liquid Chromatography Mass Spectrometry SSI-LCMS-068 Simultaneous Qualitative and Quantitative Data Acquisition for Research of Diabetes Drugs LCMS-8050 Summary By utilizing the LCMS-8050 s ultrafast scan
More informationInnovative vs Traditional
And in the red corner, introducing the challenger NASDAQ April 4 2011 243.47 $ 1.38 $ 0.58 % 0.07 $ 0.02 $ 39.4 % Technology DVD Digital Streamline Instant Play Internet Access Unlimited Selection No Late
More informationFipronil Analysis By GC/XSD following Post-Extraction Gel Permeation Chromatography Cleanup
Application Note 25570306 Fipronil Analysis By GC/XSD following Post-Extraction Gel Permeation Chromatography Cleanup Keywords Gel Permeation Chromatography GPC AutoPrep 2000 Pesticides RapidVap N2 System
More informationThe Facts on Equine Drug Testing
The Facts on Equine Drug Testing CONTACT Travis Mays, MS Interim Section Head Analytical Chemistry, Drug Testing Laboratory Toxicology Laboratory 979.845.3414 tmays@ LIMITATIONS IN DRUG TESTING While advancements
More informationASSURING THE QUALITY OF TEST RESULTS
Page 1 of 12 Sections Included in this Document and Change History 1. Purpose 2. Scope 3. Responsibilities 4. Background 5. References 6. Procedure/(6. B changed Division of Field Science and DFS to Office
More informationOverview. Introduction. AB SCIEX MPX -2 High Throughput TripleTOF 4600 LC/MS/MS System
Investigating the use of the AB SCIEX TripleTOF 4600 LC/MS/MS System for High Throughput Screening of Synthetic Cannabinoids/Metabolites in Human Urine AB SCIEX MPX -2 High Throughput TripleTOF 4600 LC/MS/MS
More informationVALIDATION OF ANALYTICAL PROCEDURES: TEXT AND METHODOLOGY Q2(R1)
INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE ICH HARMONISED TRIPARTITE GUIDELINE VALIDATION OF ANALYTICAL PROCEDURES: TEXT AND METHODOLOGY
More informationExtraction of Epinephrine, Norepinephrine and Dopamine from Human Plasma Using EVOLUTE EXPRESS WCX Prior to LC-MS/MS Analysis
Application Note AN844 Extraction of, and from Human Plasma Using EVOLUTE EXPRESS WCX Page 1 Extraction of, and from Human Plasma Using EVOLUTE EXPRESS WCX Prior to LC-MS/MS Analysis Introduction Catecholamines
More informationAppNote 1/2014. Automated Hydrolysis, DPX Extraction and LC/MS/MS Analysis of Pain Management Drugs from Urine KEYWORDS ABSTRACT
AppNote 1/2014 Automated Hydrolysis, DPX Extraction and LC/MS/MS Analysis of Pain Management Drugs from Urine Fred D. Foster, John R. Stuff, Edward A. Pfannkoch GERSTEL, Inc., 701 Digital Dr. Suite J,
More informationThe Use of Micro Flow LC Coupled to MS/MS in Veterinary Drug Residue Analysis
The Use of Micro Flow LC Coupled to MS/MS in Veterinary Drug Residue Analysis Stephen Lock AB SCIEX Warrington (UK) Overview A rapid, robust, sensitive and specific LC-MS/MS method has been developed for
More informationOverview. Triple quadrupole (MS/MS) systems provide in comparison to single quadrupole (MS) systems: Introduction
Advantages of Using Triple Quadrupole over Single Quadrupole Mass Spectrometry to Quantify and Identify the Presence of Pesticides in Water and Soil Samples André Schreiber AB SCIEX Concord, Ontario (Canada)
More informationSPE and HPLC. Dr Iva Chianella Lecturer in Analytical Chemistry Cranfield Health +44 (0) 1234 758322. i.chianella.1998@cranfield.ac.
SPE and HPLC Dr Iva Chianella Lecturer in Analytical Chemistry Cranfield Health +44 (0) 1234 758322 i.chianella.1998@cranfield.ac.uk Solid-Phase Extraction- SPE Simple, fast and efficient sample preparation
More informationThermo Scientific SOLAµ SPE Plates Technical Guide. Consistent excellence. for bioanalysis
Thermo Scientific SOLAµ SPE Plates Technical Guide Consistent excellence for bioanalysis SOLAµ - delivering reproducible low volume extractions. Everytime! Thermo Scientific SOLAµ plates are designed for
More informationValidation and Calibration. Definitions and Terminology
Validation and Calibration Definitions and Terminology ACCEPTANCE CRITERIA: The specifications and acceptance/rejection criteria, such as acceptable quality level and unacceptable quality level, with an
More informationMethod development for analysis of formaldehyde in foodsimulant. melamine-ware by GC-MS and LC-MS/MS. Internal Technical Report
of melamine-ware by GC-MS and LC-MS/MS Page 1 of 15 Method development for analysis of formaldehyde in foodsimulant extracts of melamine-ware by GC-MS and LC-MS/MS December 2012 Contact Point: Chris Hopley
More informationHigh sensitivity assays using online SPE-LC-MS/MS -How low can you go? Mohammed Abrar Unilabs York Bioanalytical solutions, York, UK
High sensitivity assays using online SPE-LC-MS/MS -How low can you go? Mohammed Abrar Unilabs York Bioanalytical solutions, York, UK Background Unilabs YBS are a bioanalytical CRO based in York (Uk) Copenhagen
More informationAccurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances
Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances TripleTOF 5600 + LC/MS/MS System with MasterView Software Adrian M. Taylor AB Sciex Concord, Ontario (Canada) Overview
More informationAppNote 1/2012. Rapid Cleanup and Comprehensive Screening of Pain Management Drugs in Urine using Automated Disposable Pipette Extraction and LC-MS/MS
AppNote 1/2012 Rapid Cleanup and Comprehensive Screening of Pain Management Drugs in Urine using Automated Disposable Pipette Extraction and LC-MS/MS Oscar G. Cabrices, Fred D. Foster, John R. Stuff, Edward
More informationSTANDARD OPERATING PROCEDURES
PAGE: 1 of 33 CONTENTS 1.0 SCOPE AND APPLICATION 2.0 METHOD SUMMARY 3.0 SAMPLE PRESERVATION, CONTAINERS, HANDLING, AND STORAGE 4.0 INTERFERENCES AND POTENTIAL PROBLEMS 5.0 EQUIPMENT/APPARATUS 6.0 REAGENTS
More informationSimultaneous Quantitation of 43 Drugs in Human Urine with a Dilute-and-Shoot LC-MS/MS Method
Simultaneous Quantitation of 4 Drugs in Human Urine with a Dilute-and-Shoot LC-MS/MS Method Xiang He and Marta Kozak, Thermo Fisher Scientific, San Jose, CA Application Note 76 Key Words TSQ Quantum Access
More informationAnalysis of Organophosphorus Pesticides in Milk Using SPME and GC-MS/MS. No. GCMS-1603. No. SSI-GCMS-1603. Shilpi Chopra, Ph.D.
Gas Chromatograph Mass Spectrometer No. GCMS-1603 Analysis of Organophosphorus Pesticides in Milk Using SPME and GC-MS/MS Shilpi Chopra, Ph.D. Introduction Organophosphorus (OP) pesticides are a class
More information1.2 This TAP is applicable to concrete, charcoal, coral, debris, wipes and soil.
March 2012 8 1 of 17 1.0 SCOPE 1.1 This procedure describes the preparation and analysis of solid matrices and wipe samples. 1.2 This TAP is applicable to concrete, charcoal, coral, debris, wipes and soil.
More informationGUIDELINES ON THE USE OF MASS SPECTROMETRY (MS) FOR IDENTIFICATION, CONFIRMATION AND QUANTITATIVE DETERMINATION OF RESIDUES CAC/GL 56-2005
CAC/GL 56-2005 Page 1 of 6 GUIDELINES ON THE USE OF MASS SPECTROMETRY (MS) FOR IDENTIFICATION, CONFIRMATION AND QUANTITATIVE DETERMINATION OF RESIDUES CAC/GL 56-2005 CONFIRMATORY TESTS When analyses are
More information8. SUMMARY AND CONCLUSION
238 8. SUMMARY AND CONCLUSION The present work aimed to assess the applicability of High Performance Liquid Chromatography with Mass Spectrometry (HPLC-MS) for analysis of different class of drugs in rat,
More informationDetermination of Tetracycline Antibiotics in Milk Using a Simple Strong Cation-Exchange SPE Cleanup Procedure and LC-MS/MS Analysis
Determination of Tetracycline Antibiotics in Milk Using a Simple Strong Cation-Exchange SPE Cleanup Procedure and LC-MS/MS Analysis UCT Product Numbers: CSDAU26: 2mg / 6mL SPE cartridge SLDA1ID21-3UM:
More informationGuide to Quality in Analytical Chemistry
CITAC / EURACHEM GUIDE Guide to Quality in Analytical Chemistry An Aid to Accreditation Prepared jointly by CITAC (The Cooperation on International Traceability in Analytical Chemistry) and EURACHEM (A
More informationTechnical Report. Automatic Identification and Semi-quantitative Analysis of Psychotropic Drugs in Serum Using GC/MS Forensic Toxicological Database
C146-E175A Technical Report Automatic Identification and Semi-quantitative Analysis of Psychotropic Drugs in Serum Using GC/MS Forensic Toxicological Database Hitoshi Tsuchihashi 1 Abstract: A sample consisting
More informationDaniel M. Mueller, Katharina M. Rentsch Institut für Klinische Chemie, Universitätsspital Zürich, CH-8091 Zürich, Schweiz
Toxichem Krimtech 211;78(Special Issue):324 Online extraction LC-MS n method for the detection of drugs in urine, serum and heparinized plasma Daniel M. Mueller, Katharina M. Rentsch Institut für Klinische
More informationImproved Method for the Analysis of 31 Drugs of Abuse in Oral Fluid samples using the Thomson extreme FV by LC-MS/MS
htslabs.com folks@htslabs.com 800 541.4792 760 757.8080 760 757.9367 Improved Method for the Analysis of 31 Drugs of Abuse in Oral Fluid samples using the Thomson extreme FV by LC-MS/MS Nadine Koenig 2,
More informationQuality Assurance (QA) & Quality Control (QC)
Quality Assurance (QA) & Quality Control (QC) In the laboratory Georges Ruta Water Quality Scientist City West Water 1 City West Water Water Supply & Sewerage Authority Melbourne Pop. >800,000 Area 580
More informationDetermination of Haloacetic Acids and Dalapon in Drinking Water by SPE and GC/ECD*
Method 552.1 Revision 1.0 Determination of Haloacetic Acids and Dalapon in Drinking Water by SPE and GC/ECD* UCT Products: EUQAX156 (quaternary amine with Cl - counter ion, 6 ml cartridge)** CLTTP050 (CLEAN-THRU
More informationA feasibility study of the determination of B-group vitamins in food by HPLC with Mass Spectrometric detection. LGC/R/2011/181 LGC Limited 2011
A feasibility study of the determination of B-group vitamins in food by HPLC with Mass Spectrometric detection LGC/R/2011/181 LGC Limited 2011 GC11/0005A A feasibility study of the determination of B-group
More informationPerformance and advantages of qnmr measurements
Return to Web Version This is the first of a series of articles related to the launch of new organic CRMs certified by quantitative NMR under double accreditation. In this issue, we focus on CRMs intended
More informationHow To Get A Laboratory License In Washington
Application for Initial Certification as a Third-Party Laboratory allowed to conduct required quality assurance tests under WAC 314-55-102 V.1.0 Overview An expectation of the Washington State Liquor Control
More informationORGANIC SAMPLE PREPARATION
ORGANIC SAMPLE PREPARATION W W W.LA BT E C H S R L.CO M WSPE MANUAL VACUUM MANIFOLD SPE Process control of the flow rate is critical to guarantee reproducible extractions. Differently then any other systems,
More informationAUDIT PROTOCOL FOR THE VICTORIAN WATER QUALITY MONITORING NETWORK
AUDIT PROTOCOL FOR THE VICTORIAN WATER QUALITY MONITORING NETWORK ENVIRONMENT PROTECTION AUTHORITY June 1999 AUDIT PROTOCOL FOR THE VICTORIAN WATER QUALITY MONITORING NETWORK, June 1999 David Robinson
More informationGuide to achieving reliable quantitative LC-MS measurements
Guide to achieving reliable quantitative LC-MS measurements Guide to achieving reliable quantitative LC-MS measurements RSC Analytical Methods Committee Editor Mike Sargent First Edition 2013 Contributors
More informationStep-by-Step Analytical Methods Validation and Protocol in the Quality System Compliance Industry
Step-by-Step Analytical Methods Validation and Protocol in the Quality System Compliance Industry BY GHULAM A. SHABIR Introduction Methods Validation: Establishing documented evidence that provides a high
More informationDetermination of PCDD/Fs in Environmental Samples using Accelerated Solvent Extraction (ASE) and GC-MS/MS
Determination of PCDD/Fs in Environmental Samples using Accelerated Solvent Extraction (ASE) and Paul Silcock, 1 David Gardner, 2 John Fardon, 2 Steve Moss 2 and Inge de Dobbeleer 1 1 Thermo Scientific
More informationAgilent Enhanced Matrix Removal Lipid LOSE THE LIPIDS, FIND YOUR ANALYTES
Agilent Enhanced Matrix Removal Lipid LOSE THE LIPIDS, FIND YOUR ANALYTES AGILENT ENHANCED MATRIX REMOVAL LIPID ARE LIPIDS WEIGHING YOUR SAMPLES DOWN? Interference from lipids is a problem for labs measuring
More informationThe Automated SPE Assay of Fipronil and Its Metabolites from Bee Pollen.
The Automated SPE Assay of Fipronil and Its Metabolites from Bee Pollen. Mark Crawford Single Presenter Name Abstract With the recent decline in hive bee populations this year the investigation of acaricides
More informationC 5. chemical development contract research custom synthesis cgmp API manufacturing commercial production. Welcome to
C 5 chemical development contract research custom synthesis cgmp API manufacturing commercial production Welcome to ChemCon Company profile Company profile ChemCon offers outstanding chemical services
More informationOnline SPE-LC-APCI-MS/MS for the Determination of Steroidal Hormones in Drinking Water
Online SPE-LC-APCI-MS/MS for the Determination of Steroidal ormones in Drinking Water presented by Paul Fayad, Ph.D. Candidate under the supervision of Sébastien Sauvé, Ph.D. Department of Chemistry paul.fayad@umontreal.ca
More informationQuality Assurance Manual
Clinical Laboratory of San Bernardino, Inc. Quality Assurance Manual Clinical Laboratory of San Bernardino, Inc. 21881 Barton Road, Grand Terrace, CA 92313 Telephone (909) 825-7693 Facsimile (909) 825-7696
More informationCERTIFICATE OF ANALYSIS
Attention: Angela Mazza / Kathleen Wilson Catholic Education Centre 80 Sheppard Ave E North York, ON M2N 6E8 Your Project #: ANNUNCIATION Your C.O.C. #: na Report #: R3046860 Version: 1 MAXXAM JOB #: B488250
More informationANALYTICAL METHODS INTERNATIONAL QUALITY SYSTEMS
VALIDATION OF ANALYTICAL METHODS 1 GERT BEUVING INTERNATIONAL PHARMACEUTICAL OPERATIONS TASKS: - Internal auditing - Auditing of suppliers and contract manufacturers - Preparing for and guiding of external
More informationExtraction of Cannabinoids in Marijuana and Edibles by QuEChERS
Extraction of Cannabinoids in Marijuana and Edibles by QuEChERS UCT Part Numbers: ECQUEU750CT-MP - QuEChERS, Mylar packs containing 4 g magnesium sulfate, 1 g sodium chloride, 0.5 g sodium citrate dibasic
More informationAnalysis of Pesticides in Vegetables Using the Agilent 1260 Infinity Analytical SFC System with Triple Quadrupole MS Detection
Analysis of Pesticides in Vegetables Using the Agilent 1260 Infinity Analytical SFC System with Triple Quadrupole MS Detection Application Note Food Testing & Agriculture Authors Edgar Naegele and Thomas
More informationOpiates in Urine by SAMHSA GC/MS
application Note Gas Chromatography/ Mass Spectrometry Author Timothy D. Ruppel PerkinElmer, Inc. Shelton, CT 06484 USA Opiates in Urine by SAMHSA GC/MS Introduction The United States Department of Health
More information1 Quality Assurance and Quality Control Project Plan
1 Quality Assurance and Quality Control Project Plan The purpose of this section is to describe the quality assurance/quality control program that will be used during the system specific field testing
More informationAnalysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column
Analysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column Sachiki Shimizu, FUJIFILM Fine Chemicals Co., Ltd., Kanagawa, Japan Kenneth J. Fountain, Kevin Jenkins, and Yoko Tsuda,
More informationCertifying Reference Materials to ISO Guide 34
Certifying Reference Materials to ISO Guide 34 Gill Holcombe Head of Reference Materials Production Environmental Laboratory Quality Day 17 November 2011 4005 Outline LGC background Quality systems - ISO
More informationRequest for Quotes Goods/Trade Services RFQ for Gas Chromatograph Mass Spectrometer (GCMS) (PCS# 600000-1621-RFQ)
Request for Quotes Goods/Trade Services RFQ for Gas Chromatograph Mass Spectrometer (GCMS) Closing Date and Time: Wednesday, April 13, 2016 at 5:00 p.m. (Pacific Time) Contact: Aaron Galloway Fax: 541-888-3250
More informationIncreasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening
Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening Application Note Forensics Author Erin Shonsey Director of Research Alabama Department of Forensic Science Abstract
More informationCriteria for Quality Control Protocols for Various Algal Toxin Methods [Project #2942]
Criteria for Quality Control Protocols for Various Algal Toxin Methods [Project #2942] ORDER NUMBER: 2942 DATE AVAILABLE: April 2012 PRINCIPAL INVESTIGATORS: John Papageorgiou, Brenton Nicholson, Wasa
More informationQA/QC. Standard methods in field. QA/QC in the field. QA/QC in analysis
QA/QC To identify, measure and keep systematic and random errors under control in planning, sampling, analysis and reporting of data. Quality assurance = how samples and data are collected and managed.
More informationTechnical Guidance Manual for the Implementation of the Hawai`i State Contingency Plan. Interim Final SECTION 10
Technical Guidance Manual for the Implementation of the Hawai`i State Contingency Plan SECTION 10 DATA QUALITY ASSURANCE AND QUALITY CONTROL (QA/QC) Hawai`i HEER TGM 10-1 December 31, 2008 CONTENTS Acronyms
More informationBenzo[a]pyrene Method Development
Benzo[a]pyrene Method Development Dr Michael Intorp CORESTA Cooperation Center for Scientific Research Relative to Tobacco FDA Center for Tobacco Products Scientific Workshop Tobacco Product Analysis 30
More informationImplementing New USP Chapters for Analytical Method Validation
Implementing New USP Chapters for Analytical Method Validation March 2010 Ludwig Huber Fax.: +49 7243 602 501 E-mail: Ludwig_Huber@labcompliance.com Today s Agenda Handling Method Changes vs. Adjustments
More information