CTL RSV RSV. CTL T cell receptor TCR HLA class HLA B52 B7. clonal expansion CTL CTL clone B52 B7. T cytotoxic T lymphocyte MHC CTL B52 B7
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1 2014 Vol. 26No RS RS RSV RSV 1978 T cytotoxic T lymphocyte CTL MHCHLA ZinkernagelDoherty 1 CTL MHC CTL HLA B52 B7 2 3 CTL T cell receptortcr HLAclass 3 CTL HLA B52B7 TCR CTL clonal expansion CTL CTL clone B52B7 B52B NY Ogra
2 CTL 1 CTL 23 RSV 20 3 RSV RSV 1 RSV RSV A B AB 2 CTL HLA HLA B52B7
3 2014 Vol. 26No RSV HEp PCR RSV G RSV G 60 B RSV AB
4 RSV RSV IgAIgG IgA IgG 2 IgA 0.1 mgml RSV 1 RSV RSV RSV RSV RSV nasopharyngeal secretionnps IgA IgG IgG 12 5 RSV RSV RSV 7 RSV 2 12 RSV IL6TNF 8 13 in vitro RSV
5 2014 Vol. 26No RSV RSV IgAIgG RSV IgAIgG IgA 0.1 mgml mrna ,15 in vitro RSV NO 16,17 9 RSV RSV TLR3 TLR4 2 RNARSV F LPS HDM house dust miteil 8 RANTES l l 7RSV 2 HE 8RSV IL6 TNF IL6TNF IgA 0.1 mgml 1821 LT
6 RSV 10RSV 10RSV RSV TLR4 SNPs RSV 3 RS RSV 11 RSV 2 in vivo in vitro RSV htert in vivo
7 2014 Vol. 26No RSV RSV RSV 24 RSV RSV RSV occludinclaudin 4 RSV RSV TGFPKCHIF1NF B 12 24,25 26,27 RS RSV reactive airway diseaserad NTT RSV 1 1 RSV RSV 28 RSV MMPmatrix metalloproteinase MMP10 29 MMP10 RSV RAD RS 20 RSV 2
8 RSV RSV TGFPKCHIF1NFB RSV RSV RSV RSV RSV RSV RSV RSV RSV RSVF MAbFDA CLD CHD RSV RSV ELISA RSV RSV MedImmune 1998 RSV complementarity determining regioncdr IgG RSV AB RSV RSV
9 2014 Vol. 26No RSV 33 RSV RSV serendipity 2 1Zinkernagel RM, et alrestriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature , Tsutsumi H, et altcellmediated cytotoxic response to mumps virus in humans. Infect Immun , Chiba Y, et alhuman leukocyte antigenlinked genetic controls for T cellmediated cytotoxic response to mumps virus in humans. Infect Immun , Tsutsumi H, et almonoclonal antibodies to the large glycoproteins of respiratory syncytial virus possible evidence for several functional antigenic sites. J Gen Virol , Tsutsumi H, et aloccurrence of respiratory syncytial virus subgroup A and B strains in Japan, 1980 to J Clin Microbiol , Tsutsumi H, et alantigenic variation of human RSV strains isolated in Japan. J Med Virol , Seki K, et algenetic variability of respiratory syncytial virus subgroup a strain in 15 successive epidemics in one city. J Med Virol , Kamasaki H, et algenetic variability of respiratory syncytial virus subgroup B strain isolated during the last 20 years from the same region in Japanexistence of timedependent linear genetic drifts. Arch Virol , Kuroiwa Y, et ala phylogenetic study of human respiratory syncytial viruses group A and B strains isolated in two cities in Japan from J Med Virol , Nagai K, et alnosocomial outbreak of respiratory syncytial virus subgroup B variants with the 60 nucleotidesduplicated G protein gene. J Med Virol , Tsutsumi H, et aldifferent kinetics of antibody responses between IgA and IgG classes in nasopharyngeal secretion in infants and children during
10 primary respiratory syncytial virus infection. Acta Pediatr Jpn , respiratory syncytial virus Matsuda K, et aldevelopment of interleukin 6 and tumor necrosis factor alpha activity in nasopharyngeal secretions of infants and children during infection with respiratory syncytial virus. Clin Diagn Lab Immunol , Matsuda K, et alcharacteristics of IL6 and TNFalpha production by respiratory syncytial virusinfected macrophages in the neonate. J Med Virol , Tsutsumi H, et alrespiratory syncytial virus induced cytokine production by neonatal macrophages. Clin Exp Immunol , Takeuchi R, et alrespiratory syncytial virus infection of human alveolar epithelial cells enhances interferon regulatory factor 1 and interleukin1betaconverting enzyme gene expression but does not cause apoptosis. J Virol , Tsutsumi H, et alrespiratory syncytial virus infection of human respiratory epithelial cells enhances inducible nitric oxide synthase gene expression. J Leukoc Biol , Groskreutz DJ, et alrespiratory syncytial virus induces TLR3 protein and protein kinase R, Leading to increased doublestranded RNA responsiveness in airway epithelial cells. J Immunol , KurtJones EA, et alpattern recongnition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nature Immunol , Monick MM, et alrespiratory syncytial virus upregulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Birol Chem , Hammad H, et alhouse dust mite allergen induces asthma via Tolllike receptor 4 triggering of airway structural cells. Nature Med , Tal G, et alassociation between common Toll like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis , Fernandes RM, Bialy LM, Vandermeer B, et al Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev CD004878, Masaki T, et ala NFB signaling pathway via protein kinase C regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells. Mol Biol Cell , Tsutsumi H, et alrespiratory syncytial virus infection and the tight junctions of nasal epithelial cells. Adv Otorhinolaryngol , Obata K, et alcurcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One 188e70225, Fuchimoto J, et alhumulone suppresses replication of respiratory syncytial virus and release of IL8 and RANTES in normal human nasal epithelial cells. Med Mol Morphol , RS , Hirakawa S, et almarked induction of matrix metalloproteinase10 by respiratory syncytial virus infection in human nasal epithelial cells. J Med Virol , RSV respiratory syncytial virusrsv Directigen RSV respiratory syncytial virus Kuroiwa Y, et alcomparison of an immunochromatography test with multiplex reverse transcriptionpcr for rapid diagnosis of respiratory syncytial virus infections. J Clin Microbiol , RS
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