Scientific Program. Advances in the Treatment of Digestive Tumours. Symposium. International. Under the auspices of: Accredited by:

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1 Advances in the Treatment of Digestive Tumours Scientific Program 22 International Symposium Barcelona (Spain) 11th and 12th December 2014 HOTEL BARCELÓ SANTS Under the auspices of: FEDERATION OF SPANISH SOCIETIES OF ONCOLOGY Accredited by: Scientific and Sanitary Interest Accredited by: Organized by: MINISTRY OF HEALTH, SOCIAL SERVICES AND EQUALITY SPANISH COOPERATIVE GROUP FOR DIGESTIVE TUMOUR THERAPY

2 2 Introduction We are pleased to announce the XXII International Symposium of the TTD Group. This year we are striving to offer an innovative program which will not only include new topics, but also new formats which will greatly enable open discussions. Our objective is to facilitate a fluid dialog, a spontaneous exchange of ideas which, in addition to lending itself to a more enriching debate, will also ensure greater interest and participation on the part of the attendees. Along these lines there will be two open discussions whose format will be similar to that of the TV program 59 Seconds, a format that allows for a debate on colorectal biological markers and the clinical benefit versus cost efficiency in the therapeutic positioning of new drugs, similar to the debate format of Oxford Debate in which pancreatic cancer (Folfirinox versus GEM-Nab-Paclitaxel) will be discussed. Among the new topics this year we would like to highlight the clinical and biological features that are becoming clinically relevant in colorectal cancer, such as the importance of localizing the tumor or gender as it relates to prognosis and treatment, or the benefits of aspirin and metformin in prevention and treatment. Along with these topics, there will be talks that will help us better understand illness with an in-depth look at its molecular mechanisms in order to improve early detection, classification, and treatment. The program will also include a round-table discussion on neuroendocrine tumors with talks that will provide complementary information regarding the results of recent clinical studies with sights on a possible optimization of administration and sequencing. Because there is no room to include an exhaustive review of all tumors, we ve included a roundtable on new discoveries regarding other tumors. We hope that you join us with a desire to actively participate and that you find this new program format to your liking. Albert Abad (UCCO-Iradier, Campus CIMA Sanitas) José Luis Manzano (ICO. Hospital Universitari Germans Trias i Pujol) Ramon Salazar (ICO. Hospital Duran i Reynals) Josep Tabernero (Hospital Universitari Vall d Hebrón) Barcelona

3 Advances in the Treatment of Digestive Tumours 22 International Symposium Organization 3 ORGANIZING COMMITTEE: COORDINATOR Albert Abad UCCO-Iradier, Campus CIMA Sanitas José Luis Manzano ICO. Hospital Universitari Germans Trias i Pujol Badalona, Spain Ramón Salazar ICO. Hospital Duran i Reynals José Mª Tabernero Hospital Universitari Vall d Hebrón ORGANIZING COMMITTEE: VOCALS Antonio Antón Miguel Servet Zaragoza, Spain Enrique Aranda Reina Sofía Córdoba, Spain Manuel Benavides Hospital Regional Universitario Málaga, Spain Alfredo Carrato Ramón y Cajal Eduardo Díaz-Rubio Clínico San Carlos Pilar García Alfonso Gregorio Marañón Cristina Grávalos 12 de Octubre Bartomeu Massutí Hospital General Universitario Alicante, Spain Fernando Rivera Marqués de Valdecilla Santander, Spain Javier Sastre Clínico San Carlos Manuel Valladares Complejo Hospitalario Universitario La Coruña, Spain José María Viéitez Central de Asturias Oviedo, Spain Jesús García-Foncillas Fundación Jiménez Díaz

4 4 Faculty Albert Abad UCCO-Iradier, Campus CIMA Sanitas Antón, Antonio Miguel Servet Zaragoza, Spain Aranda, Enrique Reina Sofía Córdoba, Spain Arnold, Dirk Klinik fuer Tumorbiologie Freiburg, Germany Bardelli, Alberto University of Torino, Medical School Turín, Italy Benavides, Manuel Hospital Regional Universitario Málaga, Spain Capdevila, Jaume Vall d Hebron Carrato, Alfredo Ramón y Cajal Casanovas, Oriol IDIBELL, Hospitalet de Llobregat Clopés, Ana Farmacia ICO, Barcelona. Spain Díaz-Rubio, Eduardo Clínico San Carlos Dienstmann, Rodrigo Hospital Universitari Vall d Hebrón, y SAGE and Seattle, United States Gallego, Javier Hospital General Universitario de Elche Alicante, Spain García Alfonso, Pilar Gregorio Marañón García Carbonero, Rocío Hospital Virgen del Rocío Sevilla, Spain García-Foncillas, Jesús Fundación Jiménez Díaz Garrido, Pilar Spanish Society of Medical Oncology (SEOM) Gilabert, Antoni Gerencia de Farmacia y del Medicamento Generalitat de Catalunya Goel, Ajay Baylor University Medical Center Dallas, United States Gómez España, Auxiliadora Reina Sofía Córdoba, Spain González Flores, Encarnación Hospital Virgen de las Nieves Granada, Spain Grande, Enrique Ramón y Cajal Grávalos, Cristina 12 de Octubre López-Casasnovas, Guillem Universitat Pompeu Fabra

5 Advances in the Treatment of Digestive Tumours 22 International Symposium 5 Manzano, José Luis ICO. Hospital Universitari Germans Trias i Pujol Badalona, Spain Martínez-Balibrea, Eva Catalan Institute of Oncology (ICO) and Health Sciences Research Institute of the Germans Trias i Pujol Foundation Badalona. Spain Massutí, Bartomeu Hospital General Universitario Alicante, Spain Montagut, Clara Hospital del Mar Nadal, Cristina Hospital Clínic Navarro, Mª Dolors Spanish Patients Forum Páez, David Hospital Santa Creu i Sant Pau Pollak, Michael McGill University / Jewish General Hospital Montreal, Canada Rivera, Fernando Marqués de Valdecilla Santander, Spain Robles, Luis 12 de Octubre Ruszniewski, Philippe Beaujon Hospital Clichy, France Safont, Mª José Hospital General Universitario Valencia, Spain Salazar, Ramón ICO. Hospital Duran i Reynals Sastre, Javier Clínico San Carlos Sobrero, Alberto IRCCS Ospedale San Martino Genoa, Italy Tabernero, José María Hospital Universitari Vall d Hebrón Thirlwell, Chrissie UCL Cancer Institute London, United Kingdom Valladares, Manuel Complejo Hospitalario Universitario La Coruña, Spain Viéitez, José Mª Hospital Central de Asturias Oviedo, Spain

6 6 Scientific Program WEDNESDAY DECEMBER 10th 19:00-20:30 SATELLITE SYMPOSIUM (Sponsored by Bayer) THURSDAY DECEMBER 11th 09:00-10:00 SATELLITE SYMPOSIUM (Sponsored by Sanofi) 10:30-11:00 Welcome and introduction 1st TABLE (1st PART): CLINICAL AND MOLECULAR FACTORS OF TUMORAL VARIABILITY AND HOST Moderators: C. Montagut (Hospital del Mar, Barcelona. Spain) A. Sobrero (IRCCS Ospedale San Martino, Genoa. Italy) 11:00-11:20 11:20-11:40 11:40-12:00 12:00-12:30 Unusual prognostic and predictive factors, and biological background: primary site: proximal vs distal; gender: male vs female C. Nadal (Hospital Clínic, Barcelona. Spain) Role of Aspirin as preventive and/or therapeutic agent in mutated PI3K colorectal cancer A. Sobrero (IRCCS Ospedale San Martino IST, Genoa. Italy) Role of metformin and biguanides as preventative and/ or therapeutic agents in colorectal cancer M. Pollak (McGill University / Jewish General Hospital, Montreal. Canada) Debate and Discussion

7 Advances in the Treatment of Digestive Tumours 22 International Symposium 7 MASTER LECTURE 12:30-13:10 13:10-13:30 13:30-15:00 Molecular mechanisms of resistance to anti-egfr therapies in colorectal cancer and liquid biopsy A. Bardelli (University of Torino, Medical School, Torino. Italy) Debate and Discussion Lunch 1st TABLE (2nd PART): CLINICAL AND MOLECULAR FACTORS OF TUMORAL VARIABILITY AND HOST Moderators: JL. Manzano (ICO. Hospital Universitari Germans Trias i Pujol, Badalona. Spain) J. García-Foncillas (Fundación Jiménez Díaz, Madrid. Spain) 15:00-15:20 15:20-15:40 15:40-16:00 16:00-16:20 16:20-16:50 New molecular early detection of colon cancer A. Goel (Baylor University Medical Center, Dallas. United States) Polymorphisms and other biomarkers of resistance to oxaliplatin and fluoropyrimidines E. Martínez-Balibrea (Catalan Institute of Oncology (ICO) and Health Sciences Research Institute of the Germans Trias i Pujol Foundation (IGTP); Badalona, Spain) Polymorphisms and other biomarkers of toxicity and resistance to irinotecan D. Páez (Hospital Santa Creu i Sant Pau, Barcelona. Spain) New consensus in molecular classification for colorectal cancer R. Dienstmann (Hospital Universitari Vall d Hebrón, and SAGE, Seattle. United States) Debate and Discussion

8 8 Scientific Program 16:50-17:00 17:00-17:30 Clinical cases awards ceremony Coffee-break LECTURE 17:30-18:00 Biological sequence in colorectal cancer D. Arnold (Klinik fuer Tumorbiologie, Freiburg. Germany) 18:00-19:00 Round Table discussion Moderator: J. Tabernero (Hospital Universitari Vall d Hebrón, Barcelona. Spain) Speakers: P. García Alfonso ( Gregorio Marañón, Madrid. Spain), C. Grávalos ( 12 de Octubre, Madrid. Spain), J. Sastre (Hospital Universitario Clínico San Carlos, Madrid. Spain), M. Valladares (Complejo Hospitalario Universitario, La Coruña. Spain), M. J. Safont (Hospital General Universitario, Valencia. Spain) and J. Gallego (Hospital General Universitario de Elche, Alicante. Spain) LECTURE 19:00-19:30 Positioning of new drugs. Clinical benefit vs cost-effectiveness A. Abad (UCCO-Iradier, Campus CIMA Sanitas, Barcelona. Spain) 19:30-20:30 Round Table discussion Moderator: E. Aranda ( Reina Sofía, Cordoba. Spain) Speakers: A. Clopés (Farmacia ICO, Barcelona. Spain), G. López-Casasnovas (Departamento de Economía y Empresa de la Universitat Pompeu Fabra, Barcelona. Spain), A. Gilabert (Gerencia de Farmacia y del Medicamento, Generalitat de Catalunya, Barcelona. Spain), E. González (Hospital Virgen de las Nieves, Granada. Spain), E. Díaz-Rubio (Hospital Universitario Clínico San Carlos, Madrid. Spain), Mª D. Navarro (Spanish Patients Forum, Barcelona. Spain) and P. Garrido (Chairperson of SEOM) 20:30-21:30 Welcoming cocktail

9 Advances in the Treatment of Digestive Tumours 22 International Symposium 9 FRIDAY DECEMBER 12th 09:00-09:45 SATELLITE SYMPOSIUM (Sponsored by Celgene) 2nd Table: NEUROENDOCRINE TUMOURS: NEW MOLECULAR FINDINGS AND UPDATING OF THE TREATMENT OF ADVANCED DISEASE Moderators: R. García Carbonero (Hospital Virgen del Rocío, Sevilla. Spain) O. Casanovas (IDIBELL, Hospitalet de Llobregat. Barcelona. Spain) 10:00-10:20 10:20-10:40 10:40-11:00 11:00-11:20 11:20-11:50 11:50-12:20 Genomic landscape of neuroendocrine tumours: next steps forward into the molecular characterization of the disease Ch. Thirlwell (UCL Cancer Institute, London. United Kingdom) Using biomarkers for patient selection in advanced neuroendocrine tumours: fact or fiction? J. Capdevila (Hospital Universitari Vall d Hebrón, Barcelona. Spain) Antiproliferative effects of somatostatin analogs: clinical practice changing and future view Ph. Ruszniewski (Beaujon Hospital, Clichy. France) Sequencing strategy in advanced neuroendocrine tumours: The GETNE1002_PAZONET Experience E. Grande ( Ramón y Cajal, Madrid. Spain) Debate and Discussion Coffee-break

10 10 Scientific Program 3rd TABLE: LATEST DEVELOPMENTS IN OTHER TUMOURS Moderators: A. Antón (Hospital Miguel Servet, Zaragoza. Spain) L. Robles ( 12 de Octubre, Madrid. Spain) 12:20-12:40 12:40-13:00 13:00-13:30 Developments in the treatment of gastric cancer F. Rivera ( Marqués de Valdecilla, Santander. Spain) Developments in the treatment of rectal cancer A. Gómez España ( Reina Sofía, Córdoba. Spain) Debate and Discussion

11 Advances in the Treatment of Digestive Tumours 22 International Symposium 11 OXFORD DEBATE Optimal combination to choose for patients with advanced pancreatic cancer and PS 0: Folfirinox vs GEM-Nab-Paclitaxel Moderator: R. Salazar (ICO. Hospital Duran i Reynals, Hospitalet. Spain) 13:30-13:34 Voting 13:34-13:42 13:42-13:50 13:50-14:00 14:00-14:02 In favour of Folfirinox J. M. Viéitez ( Central de Asturias, Oviedo. Spain) In favour of GEM-Nab-Paclitaxel A. Carrato ( Ramón y Cajal, Madrid. Spain) Debate Voting 14:02-14:10 14:10-14:18 14:18-14:28 14:28-14:30 In favour of GEM-Nab-Paclitaxel B. Massutí (Hospital General Universitario, Alicante. Spain) In favour of Folfirinox M. Benavides (Hospital Regional Universitario, Málaga. Spain) Debate Voting 14:30-14:45 14:45-15:45 Final Conclusions and closure Lunch

12 12 General Information VENUE Hotel Barceló Sants Plaça dels Països Catalans, s/n Tel: ACCREDITATION All registered attendees will receive a certificate of attendance issued in their Symposium documentation. This Symposium has been awarded 11 ESMO MORA (European Society of Medical Oncology Recertification Approval) category 1 points. Symposium accredited by the Catalan Council for Continuing Education and Health Professions Continuing Education Committee of the National Health System with 1,7 credits. LANGUAGES The official languages of the Symposium will be English and Spanish, simultaneous translation will be available. WELCOMING COCKTAIL December 11th Thursday, at 20:30 h Hotel Barceló Sants LUNCH BREAKS December 11th Thursday, at 13:30 h December 12th Friday, at 14:45 h Hotel Barceló Sants Hotel Barceló Sants CONFERENCE SECRETARIAT SPANISH COOPERATIVE GROUP FOR DIGESTIVE TUMOUR THERAPY Susana Rodríguez Fernández Plaza de Castilla 3, 8º D Madrid. Spain Tel.: Fax: Mobile Phone: simposiottd@ttdgroup.org Website:

13 Advances in the Treatment of Digestive Tumours 22 International Symposium 13 REGISTRATION FEES Registration fee: 795,00 Included in the registration fee are: attendance to scientific sessions, conference materials, certificate of attendance, refreshment breaks, lunch breaks and welcoming cocktail. ACCOMMODATION Hotel Barceló Sants**** Plaça dels Països Catalans, s/n Barcelona Tel: Single room 116,90 Double room 127,85 Prices are per room and night. Breakfast and taxes included. Hotel room assigned on a first-come, first-served basis. Please, check with the Conference Secretariat for availability before the payment. FORM OF PAYMENT Registration fees can be paid by: Checks payable to: Grupo de Tratamiento de los Tumores Digestivos. Bank Transfer to: Grupo de Tratamiento de los Tumores Digestivos. Bankia. Sucursal Plaza de Castilla, 3.. Account Nº: IBAN ES BIC: CAHMESMMXXX A photocopy of payment must be sent to the conference secretariat together with the registration form. Please, include the assistant name in the bank transfer. * Cancellations: Cancellations and refund request must be submitted in writing to the Conference Secretariat. There will be a refund of 50% of the total amount for cancellations received before 14 November After this date no refunds will be made. All refunds will be processed after the conference.

14 14 Map Carrer de Numancia Carrer de Nicaragua Carrer de Robrenyo Sans Estació Carrer Enric Barges Carrer de Vallespir Carrer de Puiggan Carrer de Viriat Sans Estació Passeig de Sant Antoni Carrer Països Catalans Barcelona Sans Plaça dels Països Catalans Carrer de Provença Carrer de Tarragona Carrer Països Catalans Av. de Roma Av. de Roma Carrer de Santa Caterina Plaça de Joán Peiró Passeig de Sant Antoni HOTEL BARCELÓ SANTS Passeig de Sant Antoni Carrer de Bejar Carrer del Rector Triado Carrer de Salou Carrer de l Autonomia Carrer de Riesgo Carrer de Premià Carrer de Walt Carrer del Masnou Parc de L Espanya Industrial Carrer de Muntadas Carrer de Ermengarda Carrer del Forn

15 Advances in the Treatment of Digestive Tumours 22 International Symposium Registration Form 15 Return the complete registration form in this program by mail or fax with payment to Spanish Cooperative Group for Digestive Tumour Therapy: Mail: Plaza de Castilla 3, 8º D Madrid- Spain (Att. Susana Rodríguez Fernández) Fax: Please, keep a copy for your records. ADDRESS INFORMATION Name:... Surname:... Hospital/Institution:... Address:... Zip Code:... City:... Telephone:... Fax: ACCOMMODATION DETAILS Hotel: Barceló Sants Arrival Date:... Departure Date:... Nº nights: Type of room: Double Double PAYMENT Registration fee:... Accommodation:... Total amount to be paid:... Form of payment: By check By bank transfer Note: only forms with the corresponding payment attached will be accepted. By filling out this form and in accordance with established Organic Law 15/1999, of personal information protection, the interested party is hereby informed that the information provided of a personal nature shall be added to the files owned by the Spanish Cooperative Group for Digestive Tumour Therapy, who will be managing the 22 International Symposium of the TTD group. Additionally, we advise you that your personal data may be assigned to entities fundamentally devoted to the management and organization of the symposium, strictly to manage your attendance at the Congress properly. We would also like to inform you that you have the right to access, change, cancel and oppose this information, addressing yourself to the Group s headquarters in Plaza Castilla 3, 8th floor, D-1, 28046, Madrid. By filling out this document, you are giving your permission for manual and computerized processing of your personal details for the above mentioned usage

16 Major Sponsors: Sponsors: Other contributors: