WORKSHOP IN LUNG CANCER CLINICAL RESEARCH Improving opportunities in the LATAM region

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1 WORKSHOP IN LUNG CANCER CLINICAL RESEARCH Improving opportunities in the LATAM region April Santiago - Chile Hotel Diego de Almagro San Pío X 2530, Providencia, Santiago. INFORMATION Under the auspices of

2 COMMITTEES WORKSHOP IN LUNG CANCER CLINICAL RESEARCH Scientific Committee Organizing Committee CEO IASLC Prof. Fred Hirsch, MD, PhD University of Colorado School of Medicine DENVER, USA. Workshop Director Prof. Christian Rolfo, MD, PhD, MBAh Head of Phase I- Early Clinical Trials Unit ANTWERP, BELGIUM. Local Chair Christian Caglevic, MD Head of Early Clinical Trials Unit Local Coordinator Eva Bustamante Barra, MSc, PhD LATAM Coordinator Denisse Bretel, MD LIMA, PERU. FALP Medical Subdirector Head of Medical Oncology Unit Dr. Mauricio Mahave, MD FALP Medical Director Prof. Hugo Marsiglia, MD FALP Academic Director Luis Marín, MD APRIL 2016

3 FACULTY Felipe Bannura, MD Dept. of Thoracic Surgery FALP, CHILE. Eva Bustamante Barra, MSc, PhD Head Investigation and Development FALP, CHILE. Luis Raez, MD, FACP, FCCP, MACSG Medical Director MEMORIAL CANCER CENTER, USA. Christian Caglevic, MD Head of Early Clinical Trials Unit FALP, CHILE. Biostatistics Edgardo Santos, MD, FACP Dept. Medical Oncology LYNN CANCER INSTITUTE, USA. Felipe Cardona Zorrilla, MSc, PhD Instituto de Oncologia of Fundación Santa Fe BOGOTÁ, COLOMBIA. Isabel Gil Aldea, MD Biobank Director. NAVARRABIOMED - FUNDACIÓN MIGUEL SERVET, SPAIN. Enrique Chajon, MD Dept. of Radiotherapy CENTRE EUGENE MARQUIS, FRANCE. Ignacio Gil Bazo, MD, PhD Director Dept. Medical Oncology NAVARRA UNIVERSITY HOSPITAL, SPAIN. Marileila Varella Garcia, PhD Professor Division of Medical Oncology UNIVERSITY OF COLORADO, USA. Ana Belén Oton, MD, Associate Professor Division of Medical Oncology UNIVERSITY OF COLORADO, USA. Aung Naing, MD, FACP Associate Professor DEP. INVESTIGATIONAL CANCER THERAPEUTICS. MD ANDERSON CANCER CENTER, USA. Fred Hirsch, MD, PhD Professor of Medicine Division of Medical Oncology UNIVERSITY OF COLORADO, USA. Christian Rolfo, MD, PhD, MHBA - Professor Head of Phase I- Early Clinical Trials Unit - UNIVERSITY HOSPITAL ANTWERP BELGIUM. SANTIAGO - CHILE

4 PROGRAMME Inaugural Symposium (Open Access) WORKSHOP IN LUNG CANCER CLINICAL RESEARCH Wednesday April 27 th HOTEL DIEGO DE ALMAGRO, SALÓN PRÍNCIPE DE ASTURIAS 18:00-18:30 Inauguración PROF. HUGO MARSIGLIA, PROF. FRED HIRSCH 18:30-19:00 Charla 1 NOMBRE DEL EXPOSITOR 19:00-19:20 Charla 2 NOMBRE DEL EXPOSITOR 19:20-19:40 Charla 3 NOMBRE DEL EXPOSITOR 19:40-20:00 Charla 4 NOMBRE DEL EXPOSITOR 20:00-21:00 Cóctel APRIL 2016

5 PROGRAMME Molecular Biology Thursday April 28 th HOTEL DIEGO DE ALMAGRO, SALÓN 8:00-8:30 Registrations 8:30-9:30 Chairs Welcome: Fred Hirsch, Christian Rolfo, Christian Caglevic & Personal presentations of participants. 9:30-10:00 Knowing the IASLC: introduction, history, work and future perspectives. 10:00-10:20 Epidemiology and perspectives of Lung Cancer in Latin America. 11:00-11:15 Coffee break. 11:15-11:45 Clinical Lung Cancer research Worldwide. 11:45-12:15 Clinical Lung Cancer Research in Latin-America. 12:15-13:00 Meet the pathway I: Biomarkers in Lung Cancer I: EGFR, ALK, ROS1, MET, RAS. 13:00-13:45 Lunch & Meet the professor: integrating surgery and Immunotherapy in clinical trials. 13:45-14:30 Meet the pathway II: RET, NRTK, HER2, PI3K, BRAF and others. 14:30-15:00 Guest Starring: The molecular pathologist and his integration in multidisciplinary team. 15:00-16:20 Understanding the new technology: NGS in clinical practice. 16:20-16:30 Coffee break. 16:30-17:15 The role of Biobank in Clinical Research: Molecular Tumor Board, implementation and benefits. 17:15-18:15 Update of gold standards in Lung Cancer target therapy. 18:15-20:00 Group Excercises with Clinical Cases: Integration of Multidisciplinar Team in Clinical Research (one faculty member per group). 20:00 Reception Dinner and meet the professor. SANTIAGO - CHILE

6 PROGRAMME Implementation of Clinical Trials WORKSHOP IN LUNG CANCER CLINICAL RESEARCH Friday April 29 th HOTEL DIEGO DE ALMAGRO, SALÓN 8:00-10:15 Clinical Trials Definitions and examples Phase I Randomized trials Phase II Phase III Phase IV 10:15-11:00 Statistics: Bullet points and definitions 11:00-11:15 Coffee break 11:15-12:00 Statistics: How to integrate biomarkers in clinical the new trails design:basket, umbrella, etc 12:00-12:40 Understanding the current sacre grial of Lung Cancer: Immunotherapy Biological rationale 12:40-13:10 Current treatments in immunotherapy in Lung Cancer: critical view on evidence and response assesment 14:15-15:00 How to design a clinical trial in Lung Cancer 15:00-16:00 Group Exercise: Design your own clinical trial & Discussion (one faculty member per group) 16:00-16:20 Early Research in Radiation Oncology: SBRT and New drugs 16:20-16:50 How to read a paper? How to write a paper? 16:50-18:20 Group Exercise with Lung Cancer published papers (one faculty member per group) 18:20-18:35 Coffee break 18:35-20:30 Good Clinical Practice in Lung Cancer I 20:30-22:30 Faculty Dinner 13:10-13:30 What s after PD1- PDL1 era? New combinations and new biomarkers 13:30-14:15 Lunch & Meet the professor: APRIL 2016

7 PROGRAMME GCP and Regulatory Affairs Saturday April 30 th HOTEL DIEGO DE ALMAGRO, SALÓN 8:00-8:40 Same target different trials design, same conclusions? Stastistician and oncologist 8:40-9:10 Robotic surgery: the future for lung cancer surgical treatment? 9:10-10:00 Regulatory agencies: FDA, EMA and local (Peru,Chile, Argentina, others) Role of Pharma, Academia and CRO in Clinical Research 10:00-10:15 Coffee break 10:15-11:00 Improving the Networking in your region. Let you know: visibility in social media: LinkedIn, research gate and twitter Cooperative groups Membership of associations passive and active way 11:00-13:00 Good Clinical Practice in Lung Cancer II 13:00-13:30 Survey and exam of GCP 13:30-14:00 Close and Chairs Final Remarks 14:00-15:30 Cocktail and Certificates. SANTIAGO - CHILE

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