ESO INSIDE TRACK CONFERENCE. 4 th FAMILIAL CANCER CONFERENCE. 7-8 June 2010 Madrid, Spain. Chair: J. Benítez, ES - H. Vasen, NL MADRID 07/06/10

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1 ESO INSIDE TRACK CONFERENCE MADRID 07/06/10 4 th FAMILIAL CANCER CONFERENCE 7-8 June 2010 Madrid, Spain Chair: J. Benítez, ES - H. Vasen, NL

2 APPLICATION AND ABSTRACT SUBMISSION Poster abstract deadline 2 MAY You may apply and submit your abstract to the organising secretariat online at: Instructions for application and abstract submission Participants with new data relevant to the subject of the conference may submit one abstract to be considered for poster presentation. Only papers whose abstracts have been reviewed and approved by the conference coordinators will be presented. Abstracts should be written in English and the text should not exceed 2000 characters (or 450 words), title included. The title should appear in capital letters. For each author, type surname first, followed by first name and initials (presenting author in capital letters). List of affiliations after the author's list. Indicate 3-5 keywords at the end of the text. The full address with telephone, fax number and of the corresponding author must be provided. The corresponding author will receive all the subsequent communication concerning this abstract. Please also indicate your approval for publication in case the abstracts are issued in a journal. Six posters will be selected for the oral presentation. We will notify it to the first author before May 15th. It is the responsibility of the presenting author to ascertain whether all authors are aware of the content of the abstract before submission. FACULTY J. Palacios, Hospitales Universitarios Virgen L. Aaltonen, University of Helsinki, FI del Rocio, Sevilla, ES A. Antoniou, University of Cambridge, UK P. Radice, Fondazione IRCCS Istituto J. Benítez, Centro Nacional de Nazionale Dei Tumori, Milan, IT Investigaciones Oncológicas, Madrid, ES M. Robledo, Centro Nacional de B. Bressac de Paillerets, Institute Gustave Investigaciones Oncológicas, Madrid, ES Roussy, Villejuif, FR S. Romeo, University of Las Palmas, Las A. Castells, Hospital Clínic, Barcelona, ES Palmas de Gran Canaria, ES D. Goldgar, University of Utah, Salt Lake City, US S. Shanley, Royal Marsden Hospital, London, UK C. Houdayer, Institut Curie, Paris, FR D. Stoppa-Lyonet, Institut Curie, Paris, FR Z. Kote-Jarai, The Institute of Cancer J. Surralles, Universitat Autónoma de Research, Sutton, UK Barcelona, ES F. Lalloo, St Mary s Hospital, Manchester, UK A.M. Taylor, University Birmingham, UK P. Lapunzina, Hospital La Paz, Madrid, ES S. Thorlacius, University of Turin, IT C. Lázaro, Institut Català d'oncología, I. Tomlinson, University of Oxford, UK Barcelona, ES J. Lubinski, Pomeranian Academy of Medicine, Szczecin, PL E.R. Maher, University of Birmingham, UK A. Osorio, Centro Nacional de Investigaciones Oncológicas, Madrid, ES M. Urioste, Centro Nacional de Investigaciones Oncológicas, Madrid, ES H. Vasen, Leiden University Medical Centre, Leiden, NL

3 MONDAY, 7 JUNE GENERAL CONCEPTS IN FAMILIAL CANCER Chair: J. Benítez, ES 9:00 Welcome J. Benítez, ES 9:10 Genetic predisposition. Hereditary cancer syndromes J. Benítez, ES 9:30 Familial cancer epidemiology J. Lubinski, PL 9:50 Genetic factors and cancer predisposition A. Antoniou, UK 10:10 Evaluation of unclassified variants D. Goldgar, US 10:30 Group picture and coffee break. Poster discussion 11:00 Genetic counseling in familial cancer D. Stoppa-Lyonet, FR 11:20 Legal and ethical issues of genetic testing S. Romeo, ES 11:40 Round table HEREDITARY BREAST AND OVARIAN CANCER Chair: J. Lubinski, PL 12:00 The family of breast cancer genes A. Osorio, ES 12:20 The pathology of BRCA1 and BRCA2 breast cancer J. Palacios, ES 12:40 Selection criteria and management choices in families at high genetic risk for breast/ovarian cancer F. Lalloo, UK 13:00 Early detection and new treatments for women at high risk S. Shanley, UK 13:20 Round table 13:40 Lunch break 15:15 Oral presentation from selected posters Chair: P. Radice, IT 16:30 Coffee break and poster discussion 17:00 Clinical cases Chair: H. Vasen, NL TUESDAY, 8 JUNE COLORECTAL CANCER Chair: D. Stoppa-Lyonet, FR 9:00 Germinal genetic and epigenetic alterations in HNPCC P. Radice, IT

4 9:20 The genetic bases of FAP syndrome M. Urioste, ES 9:40 Management of patients with FAP syndrome A. Castells, ES 10:00 Other CRC genes L. Aaltonen, FI 10:20 Round table 10:40 Coffee break and poster discussion OTHER INHERITED CANCER SYNDROMES Chair: L. Altonen, FI 11:10 New advances in Multiple Endocrine Neoplasia type 2 M. Robledo, ES 11:30 The genetic portrait of familial melanoma B. Bressac de Paillerets, FR 11:50 Genetic complexity of neurofibromatosis 1 (NF1) C. Lázaro, ES 12:10 Clinical features and molecular genetics of VHL syndrome E.R. Maher, UK 12:10 Genetic and management of hereditary pancreatic syndromes H. Vasen, NL 12:50 Round table 13:10 Lunch break CANCER IN CHILDHOOD Chair: F. Lalloo, UK 14:45 The Fanconi Anemia Syndrome J. Surralles, ES 15:05 The overgrowth syndromes and cancer predisposition P. Lapunzina, ES 15:25 Familial retinoblastoma (Rb). Genotype-phenotype correlations C. Houdayer, FR 15:45 The ATM gene and Ataxia telangiectasia syndrome A.M. Taylor, UK 16:05 Round table 16:25 Coffee break and poster discussion NEW STRATEGIES IN THE SEARCH FOR CANCER GENES Chair: M. Robledo, ES 16:55 Searching for high penetrance genes by linkage studies I. Tomlinson, UK 17:15 High throughput sequencing: Searching for cancer genes S. Thorlacius, IT 17:35 GWAS and prostate cancer Z. Kote-Jarai, UK 17:55 Round table

5 HOTEL ACCOMMODATION FORM FAMILIAL CANCER, 7-8 JUNE 2010, Madrid, Spain Please fill in this form in BLOCK CAPITALS and send to: Virginia Miguel/Laura Fernández, Viajes el Corte Inglés. C/Princesa, 47 4ªPlanta Madrid, Spain Tel: Fax: Please reserve hotel accommodation by 10 May 2010 to ensure availability. After this date availability and rates will not be guaranteed and are to be confirmed on request. PARTICIPANT S DETAILS Surname PAYMENTDETAILS CREDIT CARD Visa/Mastercard American ExpressCard Holder's name Card Number / / / Exp. Date / Signature Name Address Zip Code City Country Tel Fax Mobile LIST OF HOTELS Prices are expressed in Euro and include VAT and breakfast where not indicated separately. Please indicate preferred hotel. Hotel Occidental Miguel Ángel ( ) Miguel Ángel, 31 Double room or Double for single use breakfast included 162,00 Hotel ABBA Castilla Plaza ( ) Paseo de la Castellana, 220 Double for single use breakfast included 120,00 Double occupancy breakfast included 130,00 AC Cuzco ( ) Paseo de la Castellana, 133 Double for single use breakfast included 140,00 Double occupancy breakfast included 153,00 AC Los Vascos ( ) Los Vascos, 27 Double for single use breakfast included 151,00 Double occupancy breakfast included 157,00 Tryp Centro Norte ( ) Mauricio Ravel, 10 Double for single use breakfast included 93,00 Double occupancy breakfast included 107,00 Date of arrival Date of departure Rate per (nr.)nights = Total due BANK TRANSFER: All payments made by bank transfer must include the guest's name and the Ref. 'Familial Cancer'. El Corte Ingles Travel Agency must receive a copy of the bank transfer via fax not later than 24 hours after the confirmation has been sent to the client, otherwise the reservation will be cancelled. BANK TRANSFER DETAILS Bank transfers must be made with no cost to the beneficiary addressed to: BANCO BILBAO VIZCAYA ARGENTARIA IBAN: ES BIC/SWIFT: BBVAESMMXXX OBSERVATIONS Once the confirmation is made, the cancellation policy will be send by depending on the selected hotel. El Corte Inglés Travel Agency will charge the amount to the credit card previously established as the confirmation. All cancellations must be sent writing to El Corte Inglés Travel Agency.

6 GENERAL INFORMATION ORGANISING SECRETARIAT Ana Sofia Contreiras Cordeiro/Danielle Rouse Centro Nacional de Investigaciones Oncológicas (CNIO) - Scientific Events Melchor Fernández Almagro, 3 E Madrid - Spain Tel: Fax: CONFERENCE VENUE Centro Nacional de Investigaciones Oncológicas (CNIO) Melchor Fernández Almagro, 3 E Madrid - Spain ESO SECRETARIAT Daniela Mengato European School of Oncology Via del Bollo Milan - Italy Tel: Fax: REGISTRATION AND ABSTRACT SUBMISSION AVAILABLE ONLY AT: CONFIRMATION OF REGISTRATION Registration may be carried out online (www.cnio.es/meetings). Registration fee is 200. Registration and payment must be processed by 15 May After this date registration will only be available on site at the rate of 300. The registration fee covers admission to the conference, a copy of the programme book, coffee and lunch throughout the conference as indicated in the programme. CANCELLATION OF REGISTRATION In case of cancellation without replacement, the fee less handling charges of 60 will be refunded, provided a written request is received by the Centro Nacional de Investigaciones Oncológicas (CNIO) before 15 May No refund can be made if notice of cancellation is received after this date. Refunds will be settled after the conference only. Replacements will be accepted only before 24 May OFFICIAL LANGUAGE The official language of the conference will be English. No simultaneous translation will be provided. CERTIFICATES All participants will be issued with a certificate of attendance at the close of the conference. BADGE The badge is the only official evidence of registration and should be worn at all times during the conference. Loss of badge means loss of registration. INSURANCE The organisers bear no responsibility for untoward events in connection with, before, during and after the conference. Participants are strongly advised to take out their own personal and travel insurance coverage. IMPORTANT DEADLINES 02/05/2010: poster abstracts deadline 15/05/2010: registration deadline (after this date, registration will only be available on-site) 15/05/2010: cancellation deadline 24/05/2010: replacement deadline

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