Alp Nano bio International School 4. January 27-31, 2014, Sterzing, Vipiteno (I)

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1 Alp Nano bio International School 4 January 27-31, 2014, Sterzing, Vipiteno (I) Program MONDAY 27 January 13:00-14:30 Registration 14:30-14:45 Opening Mariano Anderle, PAT Knowledge Department (Trento) Alessandro Quattrone, University of Trento RNA Biology 14:45-15:45 15:45-16:45 Irene Bozzoni, University of Rome La Sapienza Biogenesis and function of long non-coding RNAs in muscle differentiation Rory Johnson, Centre Genomic Regulation (Barcelona) Surprises from the genomic garbage dump: long non-coding RNAs after ENCODE 16:45-17:15 Coffee break 17:15-18:15 18:15-19:15 Ana Eulalio, University of Würzburg Unraveling microrna function using high-content screening Reini Fernandez De Luco, Institute of Human Genetics CNRS (Montpellier) Beyond the DNA: the role of Epigenetics and non-coding RNAs in Alternative Splicing regulation 19:15-20:00 Get together TUESDAY 28 January Methods in RNA research 08:30-09:30 09:30-10:30 Höfler Lajos, University of Oxford Nanosensors for label free DNA/RNA analysis Loredana Casalis, Elettra-Sincrotrone Trieste Single molecule atomic force microscopy imaging: a tool to study conformational properties of long DNA/RNA molecules 10:30-11:00 Coffee break 11:00-12:00 Chiara Dal Fiume, Illumina Italy ENCODE Your Research: Gene Expression and Regulation Updates 12:00-13:00 Poster viewing

2 13:00-15:00 Snow time 15:00-16:00 16:00-17:00 Markus Landthaler, Max-Delbruck Centrum (Berlin) Crosslinking-immunoprecipitation approach (PAR-CLIP) in combination with deep-sequencing to identify functional RNA-protein interactions at a nucleotide resolution Grzegorz Kudla, University of Edinburgh New methods to study the roles of protein-rna and RNA-RNA interactions in gene regulation 17:00-17:30 Coffee break 17:30-18:30 Sebastian Vencken, Royal College of Surgeons (Dublin) MicroRNA Affinity Capture Technology Paolo Gasparini, University of Trieste Public event: 20:30-22:30 "Tell me what you eat, and I will tell you what you are: from genetics of taste to sensory education" Dimmi cosa mangi e ti indicherò i tuoi geni: dalla genetica del gusto all educazione sensoriale Sag mir was du isst und ich werde Dir Deine Gene zeigen: von der Genetik des Geschmacks bis zur sinnlichen Bildung WEDNESDAY 29 January Biomedical Applications 09:00-10:00 10:00-11:00 Franco Pagani, ICGEB Trieste Fighting for the same transcript: a battle between spliceosome and microprocessor on splice site overlapping micrornas Franco Pagani, ICGEB Trieste Correction of exon skipping using Exon Specific U1 snrnas Paolo Gasparini, University of Trieste Non coding RNAs and inherited diseases 11:00-12:30 Coffee break with poster viewing 12:30-19:00 Snow time 20:30 Social dinner

3 THURSDAY 30 January Nano-on-micro approaches NEWTON project Coordinator Federico Bussolino, University of Torino 08:30-9:30 Roman Truckenmüller, University of Twente (The Netherlands) Tools for engineering artificial cellular microenvironments I session: How do cells respond to 3D microenvironment? 09:30-10:00 10:00-10:30 Luca Primo, Institute for Cancer Research and Treatment (Torino) Collective and 3D cell migration Salvatore Pece, European Institute of Oncology (Milano) Stem cells and breast cancer heterogeneity 10:30-11:00 Coffee break 11:00-11:30 Alessio Noghero, University of Torino Deciphering gene regulatory networks in sprouting angiogenesis: a next-gen approach II session: How does technology improve 3D cell culture? 11:30-12:00 12:00-12:30 12:30-13:00 Vincenzo Guarino, CNR IMCB (Napoli) Polymer based electrospun fibres for tissue engineering and cancer therapy Valentina Comunanza, University of Napoli Federico II Development of 3D organoid culture to study the tumor-microenviroment interaction Domenico Mombello, Politecnico di Torino Different technological approaches for fabrication of microfluidic 3D cells culture platforms 13:00-15:30 Snow time III session: How does technology improve 3D cell culture? 15:00-15:30 15:30-16:00 16:00-16:15 Emiliano Descrovi and Carlo Ricciardi, Politecnico di Torino Biosensing platforms based on optical and nano-mechanical transduction methods Cristina Potrich, FBK LaBSSAH (Trento) On-chip microrna purification Livio Cognolato, elab LAMP srl (Scarmagno Torino) Lab-on-Chip diagnostic platform for automated early detection of oncological RNA biomarkers

4 16:15-16:45 Filippo Causa, University of Napoli Federico II Microgel for microrna detection 16:45-17:15 Coffee break IV session: micrornas, 3D cell cultures and clinical meanings 17:15-17:45 17:45-18:15 18:15-18:45 Manuela Ferracin, University of Ferrara microrna profiling for prognostic stratification and early detection in human cancer Valentina Martino, CNR ITB (Milano) micrornas in mammary stem cells and cancer Paola Tiberio, Istituto Tumori Milano Circulating nucleic acid biomarkers in breast cancer: where we are and where we are going 20:30 Newton internal meeting FRIDAY 31 January Bioinformatics 09:00-10:00 10:00-11:00 Stefano Volinia, University of Ferrara The role of micrornas in breast cancer Davide Corà, University of Torino Integrating micrornas and long-non-coding-rnas in regulatory circuits 11:00-11:30 Coffee break 11:30-12:30 12:30 13:30 Raffaele A. Calogero, Center for Molecular Biotechnologies (Torino) Alternative Splicing Variants and Translocation-Induced Chimera detection: strength and limits of state-of-the-art bioinformatics approaches Marc Friedländer, Centre for Genomic Regulation (Barcelona) Computational analyses of small RNA sequencing data: possibilities and pitfalls 13:30-14:00 Closing and farewell lunch

5 Bozzoni Irene Calogero A. Raffaele Casalis Loredana Causa Filippo Cognolato Livio Comunanza Valentina Corà Davide Dal Fiume Chiara De Luco Reini Fernandez Descrovi Emiliano Eulalio Ana Ferracin Manuela Friedländer Marc Gasparini Paolo Guarino Vincenzo Höfler Lajos Johnson Rory Kudla Grzegorz Landthaler Markus Martino Valentina Mombello Domenico Noghero Alessio Pagani Franco Pece Salvatore Potrich Cristina Primo Luca Ricciardi Carlo Tiberio Paola Truckenmüller Roman Vencken Sebastian Uni. of Rome La Sapienza, Dept. of Biology and Biotechnology (Italy) Uni. Torino, Center for Molecular Biotechnologies (Italy) NanoInnovation Laboratory, Elettra Sincrotrone Trieste (Italy) University of Napoli Federico II (Italy) elab LAMP srl (Scarmagno Torino) (Italy) University of Torino (Italy) Institute for Cancer Research and Treatment (IRCC), Dept. of Oncology, University of Torino (Italy) Illumina srl Italy (Milano) Institute of Human Genetics CNRS, Department of Genome Dynamics Montpellier (France) Institute for Molecular Infection Biology, Uni. of Würzburg (Germany) University of Ferrara, Department of Experimental and Diagnostic Medicine (Italy) Xavier Estivill Lab, Bioinformatics and Genomics, Centre for Genomic Regulation Barcelona (Spain) University of Trieste/IRCCS Burlo Garofalo (Italy) CNR, Inst. Composite and Biomedical Materials, Napoli (Italy) University of Oxford, Chemistry Research Laboratory Centre Genomic Regulation (CRG), Computational Biology of RNA Processing Barcelona (Spain) MRC Human Genetics Unit MRC IGMM, University of Edinburgh Western General Hospital (Scotland) Max Delbruck Centrum fur Molekulare Medizin Berlin Buch (Germany) CNR, Institute of Biomedical Technologies Milano (Italy) University of Torino, Department of Oncology, Laboratory of Vascular Oncology (Italy) International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste (Italy) European Institute of Oncology, Milano (Italy) FBK, LaBSSAH Trento (Italy) Institute for Cancer Research and Treatment, Torino (Italy) Istituto Tumori Milano, Dipartimento di Oncologia Sperimentale e Medicina Molecolare (Italy) MIRA Inst. for Biomedical Technology and Technical Medicine Dept. of Tissue Regeneration, Uni. of Twente (The Netherlands) Royal College of Surgeons in Ireland, Department of Medicine Dublin (Ireland)

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