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1 of Biochemistry and Molecular Biology 1. Master the knowledge base of current biochemistry, molecular biology, and cellular physiology Describe current knowledge in metabolic transformations conducted by living cells, and their integration M Pathways and Regulation Public Non- Outline the current understanding of the structure, function and regulatory circuits in eukaryotic cells Apply the principles of Mechanistic Organic Chemistry to selected biological problems Describe in detail the current state of research on the molecular bases of heredity, gene regulation and development Identify the physical principles and limitations of current methods for analyzing macromolecules M The Nucleus M The Cytoskeleton M Cell Structure and Dynamics M Organic Mechanisms in Biology M Mechanisms in Bioorganic Chemistry Mechanisms for Preservation of Genome Integrity M Molecular Biology and Genomics M Genetics M Epigenetics M Transcription Mechanisms M Developmental Biology M Macromolecular Structure and Analysis M Biochemical and Biophysical Principles M Structure Determination M Single Molecule Biophysics X X X X X X M = of Medicine course described at M is offered by of Physiology, graduate program M , , are offered by Cell Biology M , are offered by Pharmacology and Molecular Sciences M is offered by of Physiology, graduate program M is offered by Molecular Biology and Genetics , , M are required for SOM Biological Chemistry degree M are offered by Biophysics and Biophysical Chemistry M is offered by of Physiology, graduate program 1

2 of Biochemistry and Molecular Biology 2. Develop and demonstrate breadth of knowledge in biomedical sciences and in public health Recognize the scope of modern public Public Health Perspectives on health investigations, and the role of the al Seminars molecular sciences in them Public Non- X X X Describe human health across the lifespan, identify the major root and proximate causes of morbidity and mortality, and effective strategies for promoting health and preventing disease in human populations Identify the scientific methods used in public health research and practice Discuss the interface between science and policy Molecular Biology of Carcinogenesis Public Health Perspectives on Public Health Perspectives on al Seminars Ethics and Integrity Ethics Public Health Perspectives on al Seminars X 2

3 of Biochemistry and Molecular Biology 2a. Develop and demonstrate breadth of knowledge in biomedical sciences and in public health with emphasis on the cancer problem and its relationship to the environment Discuss and evaluate current laboratory Molecular Biology of Carcinogenesis research in carcinogenesis and cancer Mechanisms For Preserving Genome Integrity biology Short s in the Oncology Center Hopkins Hospital al Seminars and s Electives in of Public Health* Public Non- X X X Identify the mechanisms of action of selected environmental genotoxins, and describe how such agents are activated and inactivated Molecular Biology of Carcinogenesis Environmental Health Principles of Toxicology al Seminars and s Electives in of Public Health* X X *Students must take 18 credits in another department of the of Public Health 2b. Develop and demonstrate breadth of knowledge in biomedical sciences and in public health with emphasis on reproductive biology Identify and describe the processes of Fundamentals of Reproductive Biology male and female gametogenesis, Reproductive Biology For Biomedical Scientists fertilization, and gestation in mammals and al Seminars and s in humans Public Non- 3

4 of Biochemistry and Molecular Biology Describe the current status of research in Molecular Endocrinology hormonal regulation in reproductive Molecular And Cellular Mechanisms of physiology. Relate these findings to the Reproduction underlying molecular alterations al s, Laboratory Meetings X X Outline the current state of knowledge of the aging of the mammalian reproductive system Molecular Endocrinology Molecular And Cellular Mechanisms of Reproduction al s, Laboratory Meetings Electives in of Public Health* X X *Students must take 18 credits in another department of the of Public Health 3. Use sequence and structural data repositories, other databases, and publication archives essential to the field Identify the principal sources of M Overview of Bioinformatics and Genomics published data and information in M Molecular Biology and Genomics molecular bioscience Current Literature al Seminars and s Use search engines to find information Use computer facilities to explore and display sequences and structures Identify uses and limitations inherent in current methods for comparing sequence and structure data Develop a program for reading the current literature in the area of interest and using these materials in research work M Computational Biology and Bioinformatics al Seminars Consultations with Adviser and Committee Public Non- X X X X M = of Medicine course described at M is offered by Molecular Biology and Genetics M is offered by Biophysics and Biophysical Chemistry 4

5 of Biochemistry and Molecular Biology Read and critically evaluate the primary literature in the area of thesis research Read and critically evaluate the primary literature in at least one area not directly relevant to current research interests Read and critically evaluate the primary literature in the area of thesis research Special Topics in Biochemistry: Molecular Regulation of Cellular Aging Special Topics in Biochemistry: Nuclear Structure and Function Special Topics in Biochemistry: Structural Basis of Macromolecular Machines al Seminars Applying for Post-Doc Position Directed Reading Preliminary Exam Preparation Independent Study X X X X X Read and critically evaluate the primary literature in at least one area not directly relevant to current research interests Special Topics In Biochemistry and Molecular Biology Seminar Directed Reading Preliminary Exam Preparation Independent Study Seminars Planning a Post-Doctoral Period X X 5

6 of Biochemistry and Molecular Biology 4. Conduct independent scholarly and experimental investigations in an area of interest Develop familiarity with research themes of Biochemical Techniques current interest al s, Laboratory Meetings Public Non- In consultation with faculty preceptor, design an experimental approach to a research problem suitable for a thesis study Design an experimental approach to a research problem in an unfamiliar area Consultation with Faculty Independent Study X X X X 5. Meet the legal and ethical requirements for research in biomedical areas Follow the ethical and legal regulations Ethics or and principles that constitute responsible Ethics and Integrity: US and research conduct International Issues Academic Ethics Module Public Non- Conduct In Laboratory X Qualify for permission to use radioisotopes, animals, and human materials as appropriate to research Radiation Safety and Dosimetry Animal Care and Use on-line Training HIPAA Training Module Committee on Human on-line Training Module X X X 6

7 of Biochemistry and Molecular Biology 6. Communicate the results of scholarship and research clearly and professionally Present research findings in a professional Biochemical Techniques fashion al Seminars and Faculty Guidance Informal s at Professional Meetings Public Non- X X Write up research results in proper form for publication in appropriate journals Readings in the Literature Written Reports and Summaries Preparing Manuscripts for Submission 7. Develop and use the skills of a competent experimental biochemist Maintain an acceptable professional laboratory notebook Biochemical Techniques Public Non- Conduct in Laboratory Prepare reagents for experimental work Biochemical Techniques Published Methods Prior Experience Laboratory Instructions 7

8 of Biochemistry and Molecular Biology Practice the safe use of radioactive Radiation Safety and Dosimetry materials, corrosive and toxic chemicals, Animal Care and Use on-line Training biohazardous materials, and any special HIPAA Training Module compounds used in active research Laboratory instructions and guidelines Prior experience and knowledge Practice the rules and principles for appropriate use of experimental subjects, both human and animal Use reagents and materials to obtain reliable and reproducible experimental results Ethics or Ethics and Integrity: US and International Issues Academic Ethics Module Animal Care and Use on-line Training HIPAA Training Module Committee on Human on-line Training Module Instruction in laboratory Instruction, demonstrations Published methods Consultation X X X 8

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