Chemical Issues in Pharmaceutical Supply Chain: A Case of Tamiflu

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Gerald Hutchinson
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1 Chemical Issues in Pharmaceutical Supply Chain: A Case of Tamiflu Wang-Kin Chiu and Yui Yip Lau Hong Kong Community College, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 2016/1/14 1

2 Agenda The primary manufacturing site is responsible for the synthesis of the active ingredient of a drug. In the manufacture or design of new synthetic routes of a drug, the logistics cost, availability of starting materials, number of steps and overall yield are critical factors to be taken into account. 2016/1/14 2

In the manufacture or design of new synthetic routes of a drug, the logistics

3 Objectives Highlight the concepts of supply chain management (SCM) in pharmaceutical industry Describe the recent advance in the synthetic chemistry of Tamiflu, focusing on the new approaches based on inexpensive starting materials. 2016/1/14 3

in the synthetic chemistry of Tamiflu, focusing on the new

4 Avian Influenza (H5N1) Influenza virus: Type A Cause severe illness Bird to bird Bird to animals Bird to humans Human to human 2016/1/14 4

5 Avian Influenza (H5N1) Source: Tang, O., & Lau, Y.Y. (2013). of avian influenza pandemic in Hong Kong. International Journal of Logistics System Logistics aspects s and Management, 14(1), /1/14 5

6 Source: online source: yahoo and google 2016/1/14 6

7 Cumulative Number of Confirmed Human Cases for Avian Influenza (H5N1), Source: World Health Organization (2015).Website: /1/14 7

8 Structure of Oseltamivir Phosphate (Tamiflu) O CO 2 Et AcHN NH 2. H3 PO 4 Oseltamivir phosphate (Tamiflu) O Shikim 2016/1/14 8

9 Structure of Shikimic Acid CO 2 Et CO H 2. H3 PO 4 ate (Tamiflu) Shikimic acid 2016/1/14 9

10 Recent Synthetic Approaches for Tamiflu Thailand Kasetsart University Singapore Nanyang Technological University The Institute of Chemical and Engineering Sciences Japan Shionogi & Co., Ltd. South Korea Ewha Womans University 2016/1/14 10

Institute of Chemical and Engineering Sciences Japan

11 Recent Synthetic Approaches for Tamiflu Hong Kong The Hong Kong Polytechnic University China Sun Yat-sen University The United States Stanford University 2016/1/14 11

12 Recent Synthetic Approaches for Tamiflu (Structure of Starting Material) O O D-glucose D-glucal O D-ribose D-mannitol O O D-mannose Lactone O EtO 2 C CO 2 Et EtO 2 C 2016/1/14 12 Diethyl d-tartrate Ethyl benzoate

D-ribose D-mannitol O O D-mannose Lactone O EtO 2 C

13 Supply Chain Management: An Physical supply materials management inbound logistics Overview Value Added Solutions Physical distribution outbound logistics Supplier s Suppliers Suppliers Manufacturers Wholesalers Retailers Information Flow Product/Service Finance Customers 2016/1/14 13

outbound logistics Supplier s Suppliers Suppliers Manufacturers

14 Sustainable Supply Chain Management (SSCM) The management of material, information and capital flows as well as cooperation among companies along the supply chain while taking goals from all three dimensions of sustainable development, i.e., economic, environmental and social, into account which are derived from customer and stakeholder requirements. 2016/1/14 14

15 Sustainable Supply Chain Management (SSCM) Strategic Orientation Pro-activity Continuity Risk Management Collaboration 2016/1/14 15

16 Strategic Orientation Drug industry requires placing equal importance on all three dimensions (i.e., economic, social and environmental) of sustainability for their decision making 2016/1/14 16

17 Continuity Select qualified supply chain partners and establish long-term relationships with supply chain partners in the drug industry 2016/1/14 17

18 Collaboration Integrate the key information and partners in the process level of SSCM. In the drug industry, joint development could contribute to developing new technologies, processes and products 2016/1/14 18

19 Risk Management Individual monitoring of specific suppliers, pressure group management and standardization of standards and certification to minimize the supply chain risk 2016/1/14 19

20 Pro-activity Stakeholders are actively engaged and learning from each other in the supply chain. Innovation is the core elements in the dynamic environments of sustainable markets. 2016/1/14 20

Innovation is the core elements in the dynamic

21 The End 2016/1/14 21

22 Q & A 2016/1/14 22

Preparing for and responding to influenza pandemics: Roles and responsibilities of Roche. Revised August 2014

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