The largest catalog of the best antibodies in the world

The largest catalog of the best antibodies in the world Primary antibodies Secondary antibodies Proteins/peptides Kits Lysates Slides Custom antibody arrays www.abcam.com Other resources Downloadable pathways and posters We work hard to gather new pathways that complement our large range of antibodies. We have pathways and posters for each of the following research areas: Cancer Immunology Neuroscience Cardiovascular Microbiology Stem Cells Chromatin and Nuclear Signaling www.abcam.com/poster Other resources Protocol library We have over 100 protocols for antibody-related applications as well as detailed troubleshooting tips to assist with your research. Western blot ELISA Immunostaining Flow Cytometry/FACS Immunoprecipitation ChIP Dot blot ELISPOT www.abcam.com/protocol www.abcam.com

cell sciences www.cytokinecenter.com www.cellsciences.com Cytokine Center Browse our web site with over 1300 proteins, including recombinant cytokines, growth factors, chemokines and neurotrophins. Daily shipping and competitive pricing are offered. Bulk quantities of many proteins available. PROTEINS 4-1BBL 4-1BB Receptor 6 Ckine ACAD8 ACAT2 gacrp30/adipolean Activin A Activin B ACY1 ADAT1 Adiponectin ADRP AITRL Akt1 Alpha-Feto Protein (AFP) Alpha-Galactosidase A Angiopoietin-1 (Ang-1) Angiopoietin-2 (Ang-2) Angiostatin K1-3 Annexin-V apo-saa Apoliprotein A-1 Apoliprotein E2 Apoliprotein E3 Apoliprotein E4 APRIL Artemin ATF2 Aurora A Aurora B BAFF BAFF Receptor BCA-1 / BLC / CXCL13 BCMA BD-1 BD-2 BD-3 BDNF Betacellulin Bivalirudin BMP-2 BMP-4 BMP-6 BMP-7 BMP-13 sbmpr-1a Brain Natriuretic Protein BRAK Breast Tumor Antigen C5a C5L2 Peptide C-10 C-Reactive Protein C-Src Calbindin D-9K Calbindin D-28K Calbindin D-29K Calmodulin Calcitonin Acetate Carbonic Anhydrase III Carcino-embryonic Antigen Cardiotrophin-1 Caspase-3 Caspase-6 CD4 CD14 CD22 CD40 Ligand / TRAP CD95 / sfas Ligand CD105 / Endoglin CHIPS CNTF Collagen CREB CTACK / CCL27 CTGF CTGFL / WISP-2 CTLA-4 / Fc CXCL16 CYR61 Cytokeratin 8 DEP-1 Desmopressin Disulfide Oxidoreductase E-selectin ECGF EGF Elafin / SKALP EMAP-II ENA-78 / CXCL5 Endostatin Enteropeptidase Eotaxin / CCL11 Eotaxin-2 Eotaxin-3 (TSC) EPHB2 EPHB4 Epigen Epiregulin Eptifbatide Erk-2 Erythropoietin (EPO) Exodus-2 Fas Ligand Fas Receptor FGF-1 (acidic) FGF-2 (basic) FGF-4 FGF-5 FGF-6 FGF-7 / KGF FGF-8 FGF-9 FGF-10 FGF-16 FGF-17 FGF-18 FGF-19 FGF-20 sfgfr-1 (IIIc) / Fc Chimera sfgfr-2 (IIIc) / Fc Chimera sfgfr-3 / Fc Chimera sfgfr-4 / Fc Chimera sflt-1 (native) sflt-1 (D3) sflt-1 (D4) sflt-1 (D5) sflt-1 (D7) Flt3-Ligand sflt-4 sflt-4 / Fc Chimera Follistatin FSH Fractalkine / CX3C G-CSF α-galactosidase A Galectin-1 Galectin-3 Gastrointestinal CA GCP-2 GDF-3 GDF-9 GDF-11 GDNF GLP-1 Glucagon GM-CSF Goserelin GPBB Granzyme B GROα GROβ GROγ GRO/MGSA Growth Hormone Growth Hormone BP GST-p21/WAF-1 HB-EGF HCC-1 HGF Histdyl-tRNA synthetase Histrelin HRG1-β1 I-309 I-TAC IFN-α IFN-α A IFN-α 2a IFN-α 2b IFN-β IFN-γ IFN-Omega IGF-I IGF-II proigf-ii IGFBP-1 IGFBP-2 IGFBP-3 IGFBP-4 IGFBP-5 IGFBP-6 IGFBP-7 IL-1α IL-1β IL-2 IL-3 IL-4 sil-4 Receptor IL-5 IL-6 sil-6 Receptor IL-7 IL-8 (72 a.a.) IL-8 (77 a.a.) IL-9 IL-10 IL-11 IL-12 IL-13 IL-13 analog IL-15 IL-16 (121 a.a.) IL-16 (130 a.a.) IL-17 IL-17B IL-17D IL-17E IL-17F IL-19 IL-20 IL-21 IL-22 IL-31 Insulin IP-10 JE JNK2a1 JNK2a2 KC / CXCL1 KGF L-asparaginase LAG-1 LALF Peptide LAR-PTP LBP LC-1 LD-78β LDH LEC / NCC-4 Leptin LIGHT LIX LKM LL-37 Lungkine / CXCL15 Lymphotactin slyve-1 M-CSF MCP-1 (MCAF) MCP-2 MCP-3 MCP-4 MCP-5 MDC (67 a.a.) MDC (69 a.a.) MDH MEC Mek-1 MIA Midkine MIG / CXCL9 MIP-1α / CCL3 MIP-1β / CCL4 MIP-3 / CCL23 MIP-3α / CCL20 MIP-3β / CCL19 MIP-4 (PARC) / CCL18 MIP-5 / CCL15 MMP-3 MMP-7 MMP-13 Myostatin Nanog NAP-2 Neurturin NFAT-1 β-ngf NOGGIN NOV NP-1 NT-1/BCSF-3 NT-3 NT-4 Ocreotide Oncostatin M Osteoprotegerin (OPG) OTOR Oxytocin p38-α PAI-1 Parathyroid Hormone PDGF-AA PDGF-AB PDGF-BB PDGF-CC Persephin PF-4 PIGF-1 PIGF-2 PKA α-subunit PKC-α PKC-γ Pleiotrophin PLGF-1 Polymyxin B (PMB) PRAS40 PRL-1 PRL-2 PRL-3 Prokineticin-2 Prolactin Protirelin PTHrP PTP1B PTP-IA2 PTP-MEG2 PTP-PEST srank srankl RANTES RELM-α RELM-β Resistin RPTPβ RPTPγ RPTPμ SCF SCGF-α SCGF-β SDF-1α SDF-1β Secretin SF20 SHP-2 STAT1 c-src TACI TARC TC-PTP TECK TFF2 TGF-α TGF-β1 TGF-β2 TGF-β3 Thymosin α1 stie-1/fc Chimera stie-2/fc Chimera TL-1A TNF-α TNF-β stnf-receptor Type I stnf-receptor Type II TPO strail R-1 (DR4) strail R-2 (DR5) TRAIL/Apo2L TSG TSH TSLP TWEAK TWEAK Receptor Urokinase EG-VEGF VEGF121 VEGF145 VEGF165 VEGF-C VEGF-C I125 VEGF-E HB-VEGF-E svegfr-1 svegfr-2 svegfr-3 Visfatin WISP-1 WISP-2 WISP-3 WNT-1 480 Neponset Street, Building 12A, Canton, MA 02021 TEL (781) 828-0610 EMAIL info@cellsciences.com CALL TOLL FREE (888) 769-1246 FAX (781) 828-0542 VISIT www.cellsciences.com

GE Healthcare Life Sciences Äsk process developers what they want in a protein purification system and what do you get? imagination at work ÄKTA, Amersham, Biacore and Whatman are trademarks of GE Healthcare companies. 2009 General Electric Company All rights reserved. First published September 2009 GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, Sweden GE12-09

Analyzing genetic differences Genotyping sample and assay technologies by QIAGEN ADNAGenotyp0909S1WW Rely on trusted automated and manual workflow solutions for: Sample collection and stabilization Genomic DNA purification, DNA storage, and whole genome amplification PCR amplification and automated QIAxcel fragment analysis HRM and Pyrosequencing detection Making improvements in life possible www.qiagen.com Sample & Assay Technologies

Antibodies and Related Reagents for Signal Transduction Research PTEN (-/-) mouse prostate using Phospho-Akt (Ser473) (D9E) XP Rabbit mab #4060 Announcing XMT a proprietary exceptional Monoclonal Technology exclusively from Cell Signaling Technology XMT enables the development and production of XP monoclonal antibodies with exceptional Performance. This revolutionary and proprietary technology provides us with access to a broad range of antibody-producing B cells unattainable with traditional monoclonal technologies, allowing more comprehensive screening and the identification of XP monoclonal antibodies with: Events Phospho-Akt (Ser473) kda 100 80 60 50 PC3 + + NIH/3T3 + for more information on XMT visit... www.cellsignal.com Phospho-Akt (Ser473) wortmannin LY294002 PDGF Insulin-treated C2C12 cells exceptional specificity + exceptional sensitivity + exceptional stability and reproducibility = exceptional Performance XMT coupled with our extensive antibody validation and stringent quality control delivers XP monoclonal antibodies with exceptional Performance in the widest range of applications. And as with all of our antibodies, the product will work the first and every time used. Phospho-Akt (Ser473) (D9E) XP Rabbit mab #4060 demonstrates exceptional Performance in a wide range of applications. See www.cellsignal.com for full validation details. 2009 Cell Signaling Technology, Inc. XMT, XP and Cell Signaling Technology are trademarks of Cell Signaling Technology, Inc Orders (toll-free) 1-877-616-2355 Technical support (toll-free) 1-877-678-8324 support@cellsignal.com Inquiries info@cellsignal.com Environmental Commitment eco.cellsignal.com

GE Healthcare Life Sciences Inspired Ägain Who better to draw inspiration for the new ÄKTA avant system than from customers using the 30,000 ÄKTA systems already in use around the world? Well, you spoke and we listened. The new ÄKTA avant system for process development is faster enabling quicker insights. It minimizes the chance of error, even while working at higher speeds. And it allows for direct, reliable scalability. At GE Healthcare Life Sciences, our focus is on helping scientists achieve even more, faster. It s a commitment we have in our genes. And all this is backed by the service, support, and investment in the future that being part of GE can bring. Want to know more? Why not talk with us today. Visit www.gelifesciences.com/aktaavant I ÄKTA I Amersham I Biacore I IN Cell Analyzer I Whatman I GE Service I The New ÄKTA avant

ÄKTA, Amersham, Biacore and Whatman are trademarks of GE Healthcare companies. 2009 General Electric Company All rights reserved. First published September 2009 GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, Sweden GE12-09

AMPLIFICATION // REAL-TIME PCR Flexible, high-throughput qpcr. Bio-Rad s CFX384 real-timepcrsystemisthebest solutionforyourhigh-throughputqpcrneeds.itcan beadaptedtoyouruniqueworkflowtoaccelerateyour discoveries with the unparalleled performance and reliability you know and trust from Bio-Rad. Get results faster with the streamlined experiment setup and powerful data analysis tools Save samples and reagents with low volume 4-target multiplex reactions; achieve optimal results with pre-developed assays Maximize your productivity even more with the CFX automation system,withwalkaway,worry-freeautomatedoperation Bring our 20 years of experience in PCR to your discovery. Visit www.bio-rad.com/ad/amplifamily/ or contact your Bio-Rad sales representative to learn more. To find your local sales office, visit www.bio-rad.com/contact/ In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) Visit us at www.bio-rad.com

Freedom of Expression Assays and Panels for Human Targets of Your Choice Function tested custom qpcr assays are now only a few clicks away with the new RealTime ready Configurator. Use this free online assay selection and shopping tool to order single assays or to configure your own custom panels on LightCycler 480 Multiwell Plates. Analyze your knockdown experiments or microarray results in the context of complex biological pathways or signaling cascades. Now online: realtimeready.roche.com Custom assay selection and custom panel configuration on the RealTime ready Configurator. For life science research only. Not for use in diagnostic procedures. This LightCycler 480 Real-Time PCR System is a real-time thermal cycler licensed for research use only under U.S. Patent No. 6,814,934 and corresponding claims in its non-u.s. counterparts, and under one or more of U.S. Patents Nosy. 5,475,610, 5,602,756, 6,703,236, 7,238,517, 7,504,241, 7,537,377 or corresponding claims in their non-u.s. counterparts, owned by Applied Biosystems, LLC. No rights are conveyed expressly, by implication or estoppels to any other patent claims. The LightCycler 480 Real-Time PCR System is not cleared for in vitro diagnostic use in the U.S. For further information on purchasing additional rights, contact the Director of Licensing at Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California, 94404, USA. No right is conveyed expressly, by implication, or by estoppels under any other patent claim, such as claims to apparatus, reagents, kits, or methods such as 5 nuclease methods. License rights to practice PCR methods under the foregoing Roche patents for research and other non-in vitro diagnostic applications may be purchased from Applied Biosystems or may be obtained by purchasing licensed reagents from Roche, Applied Biosystems, or other Authorized third party. For information on purchasing licenses for research and other non-in vitro diagnostic applications, contact the Director of Licensing at Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA. A license to practice PCR methods with other real-time detection under patents of F. Hoffmann-La Roche Ltd, and other Roche Molecular Systems ( Roche ) for in vitro diagnostic applications may be purchased from Roche or may be obtained by purchasing in vitro diagnostic reagents from Roche or any other Authorized third party. The LightCycler 480 Real-Time PCR System is not cleared for in vitro diagnostic use in the U.S. Practice of the patented 5 Nuclease Process requires a license from Applied Biosystems. The purchase of this product includes an immunity from suit under patents specified in the product insert to use only the amount purchased for the purchaser s own internal research when used with the separate purchase of Licensed Probe. No other patent rights are conveyed expressly, by implication, or by estoppel. Further information on purchasing licenses may be obtained from the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA. LIGHTCYCLER and REALTIME READY are trademarks of Roche. Other brands or product names are trademarks of their respective holders. 2009 Roche Diagnostics GmbH. All rights reserved. Conveniently select assays and configure your custom panel with interactive pathway maps or pre-selected targets. Simply add cdna and master mix to run these pre-plated, dried assays on your LightCycler 480 Instrument. Rely on function tested qpcr assays based on proven Universal ProbeLibrary technology. Visit www.realtimeready.roche.com tolearnmoreortostart configuring your next assay. Roche Diagnostics GmbH Roche Applied Science 82372 Penzberg, Germany

Inaugural issue launches 7 October 2009. Publishes every Wednesday. A new AAAS/Science resource for your library! Science Translational Medicine Integrating Medicine and Science Science Translational Medicine promotes health by facilitating communication and cooperation among those dedicated to basic, translational, and clinical research and its application. By integrating medicine and science, the original, peerreviewed research of the journal links basic scientists and clinical researchers to improve patient care worldwide. Science Translational Medicine will be presented for indexing in all leading medical, chemical, life science, and other principal indexing references as well as all major abstracting and indexing databases. Are you interested in Science Translational Medicine being available online at your institution to you and your colleagues? It s easy to recommend an institutional sitewide subscription to your library go to www.sciencemag.org/cgi/recommend_subscription Institutional sitewide subscriptions: 1-866-265-4152 (toll-free in the USA) +1-202-326-6730 (outside the USA) sciencemedicine@aaas.org ScienceTranslationalMedicine.org

Your Power for Health Improve your Microscopic Vision With CELLview Glass Bottom Cell Culture Dishes from Greiner Bio-One Designed for high-resolution microscopy and live cell imaging Embeded glass bottom for maximum planarity High transparent achromatic borsilicat glass Optimal spectral transmission and no autofluorescence Innovative design enabeling multiplex analysis Special surfaces for better cell attachment Germany (Main office): Greiner Bio-One GmbH, info@de.gbo.com l Austria: Greiner Bio-One GmbH, office@at.gbo.com Belgium: Greiner Bio-One BVBA/SPRL, info@be.gbo.com l Brazil: Greiner Bio-One Brasil, office@br.gbo.com l China: Greiner Bio-One GmbH, info@cn.gbo.com France: Greiner Bio-One SAS, infos@fr.gbo.com l Japan: Greiner Bio-One Co. Ltd., info@jp.gbo.com l Netherlands: Greiner Bio-One B.V., info@nl.gbo.com UK: Greiner Bio-One Ltd., info@uk.gbo.com l USA: Greiner Bio-One North America Inc., info@us.gbo.com www.gbo.com/bioscience

Expand your options. Automated applications that grow with you. Flexible automated systems. Easily configure your instrument to accommodate changes in your workflow. RELIABLE multichannel pipetting for plate replication Step-by-step method validation Span 8 tip shuck for reuse of tips Use your multichannel head for serial dilution by column or row Biomek 96-channel pipetting head with modified receiver sets For more information, visit www.beckmancoulter.com/labautosolutions Beckman Coulter Automation systems are part of the 2009 Stimulus PLUS Grant Award Program*, which offers special savings on Beckman Coulter products. To learn more, visit www.beckmancoulter.com/stimulus *Valid in the US only Genomics Cell Analysis Particle Characterization Capillary Electrophoresis Lab Automation Centrifugation Bioseparation Lab Tools 2009 Beckman Coulter, Inc. Beckman Coulter, the stylized logo and Biomek are registered trademarks of Beckman Coulter, Inc. Affymetrix is a registered trademark of Affymetrix, Inc.

N urosc nc Milliplex Map. Hot n w t rg ts for grow ng body of work. inf mm t on a rg s, asthm, auto mmun endocr n isoty ng To c ty M t bo sm Sk n R roduct on C nc r Bon M t bo sm C S gn ng immuno ogy Th mu t r sourc s dyn m c s your r s rch. MILLIPLEX map offers the broadest selection of biomarker immunoassay kits and reagents in a wide range of therapeutic areas, providing over 250 analytes to run on the Luminex platform plus the instruments, software and services you need, all in one place. And as your research grows, so will we. Featured Products To c ty: Kidney Toxicity Panels based on FDA/EMEA guidelines for identifying drug-induced renal damage M t bo c: Metabolic Multiplex Panels the right analytes for studying metabolic pathways across multiple organ systems N urosc nc : Human Neuropeptide Panel the premier panel in a unique neuroscience multiplex offering advancing life SCieNCe TOGeTHeR R s rch. D v o m nt. product on. D scov r STeM STeM on -sto Cell Cell ReSeaRCH: mu t ng ReSeaRCH: t www.m or.com/m a www.m or.com/st mc www.m or.com/st mc Millipore and MILLIPLEX are registered trademarks of Millipore Corporation. Luminex is a registered trademark of Luminex Corporation. Advancing Life Science Together and the Millipore logo are trademarks of Millipore Corporation. 2009 Millipore Corporation. All rights reserved.

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Your favorite cell line YOUR GENE OF INTEREST ADD. DELETE. SWAP. EDIT FOR THE BETTER. permanently Sigma and Sigma-Aldrich are registered trademarks belonging to Sigma-Aldrich Co. and its affiliate Sigma-Aldrich Biotechnology, L.P. CompoZr is a trademark of Sigma-Aldrich Co. and its affiliate Sigma-Aldrich Biotechnology, L.P.

National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health A NewNational Cancer Institute Initiative The NCI Experimental Therapeutics Program The NCI Experimental Therapeutics (NExT) Program (http://dctd.cancer.gov) is requesting project applications. The NExT program is not a grant program, but makes available to investigators the newly consolidated oncology drug discovery and development resources at NCI. The program is designed to expedite the movement of new agents from the bench to the bedside. Priority will be given to applications that focus on areas with disproportionate unmet needs. For successful applicants, whose proposals are reviewed for scientific merit, NExT provides project management support and access to resources contributed by NCI. Deadlines for the NExT program will be quarterly: November 15, February 15, May 15, and August 15 of each year. To learn more about NExT or to submit an application, go to: http://dctd.cancer.gov. ACCEPTING APPLICATIONS NOW Learn how current events are impacting your work. ScienceInsider, the new policy blog from the journal Science, is your source for breaking news and instant analysis from the nexus of politics and science. Produced by an international team of science journalists, ScienceInsider offers hard-hitting coverage on a range of issues including climate change, bioterrorism, research funding, and more. Before research happens at the bench, science policy is formulated in the halls of government. Make sure you understand how current events are impacting your work. Read ScienceInsider today. www.scienceinsider.org Breaking news and analysis from the world of science policy ENVIRONMENTAL ehp HEALTH PERSPECTIVES Published by the National Institute of Environmental Health Sciences Why read the top monthly journal in 2 categories? Number 1 monthly journal in environmental sciences and public, environmental, and occupational health Informing the environmental health community for 37 years Top resource for peer-reviewed environmental health research Objective, balanced, and current news content Discover today why EHP is number 1. Science subcriber special offer: $99 (12 issues/yr) PLUS you will receive an additional three issues for FREE when you accept our special offer. Order online at www.ehponline.org/sci09 or call 1-866-541-3841. IMPACT FACTOR 6.12 Top Monthly Journal in Environmental Sciences Public, Environmental, & Occupational Health

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AAAS/Science Business Office LIFE SCIENCE TECHNOLOGIES New Products Focus: Cell/Tissue Culture New Products Focus: Imaging and Microscopy EMCCD Camera The Evolve EMCCD Camera makes experimental data quantifiable and reproducible by using the photoelectron to measure an image. It permits researchers to obtain real-time image measurements in terms of photoelectrons, as opposed to arbitrary imaging units, without having to complete secondary calibrations, thus providing a standardized way for scientists to compare images taken on different cameras and at different gain settings. Applications include super-resolution fluorescence microscopy techniques that make it possible to track what goes on inside a cell at nanoscale. The Evolve camera lets cell biologists capture the full scope of benefits of the emerging techniques while enabling reproducibility in imaging experiments. Photometrics For information 800-874-9789 www.photomet.com Single Molecule Detection The Leica TCS SMD Series is a single molecule detection (SMD) system that offers an integrated platform for techniques such as fluorescence lifetime imaging microscopy, fluorescence correlation spectroscopy, fluorescence cross-correlation spectroscopy, and fluorescence lifetime correlation spectroscopy. The system integrates hardware and software from PicoQuant with the high-end confocal system, Leica TCS SP5 II. Leica s LAS AF software allows researchers to control a complete SMD experiment via one interface. The user-friendly system includes dedicated application wizards that guide the user step by step through SMD experiments and maximize the reproducibility of data. It features the universal SMD raw data format, in which a data file can be analyzed in various ways. Field upgrades of the Leica TCS SP5 and SP5 II confocal systems to TCS SMD systems are possible. Leica For information +49-(0)-621-70282801 www.leica-microsystems.com Microscope Family The all-in-one FSX100 fluorescence and FluoView FV10i confocal laser scanning microscope systems enable even the most inexperienced users to create high-end research images. The all-in-one microscopes are designed to remove all of the complex steps involved in setting up and using advanced fluorescence and confocal microscopes, ensuring that users can concentrate on the images and data without any prior expertise in the control of the many components involved. By coupling high-quality microscopy and imaging hardware with precision automation and advanced software, the Olympus FSX100 and FluoView FV10i present simplified workflows so users can obtain high-quality images and image series by: loading their sample, defining their observation mode and regions of interest, and then capturing their images. It s as simple as set-select-capture. Olympus For information +49-40-2-37-73 5426 www.microscopy.olympus.eu Fluorescent Dyes and Kits The DyLight 350 Fluorescent Dye is for the direct labeling of proteins and other biomolecules. The new dye, a derivative of aminomethylcoumarin acetate, fluoresces blue with excitation and emission wavelengths of 353 nm and 432 nm, respectively. The ultraviolet-excitable DyLight 350 Dye is a better choice for multiplexing experiments with green fluorophores. It is also more soluble, allowing for higher incorporation of the dye into biomolecules. Its resistance to photobleaching enables data collection under demanding conditions. The DyLight 350 Dye can be measured with common fluorescence instrumentation. It is available as an aminereactive ester or a sulfhydryl-reactive maleimide. DyLight 350 Antibody Labeling Kits are also available, with all the components necessary to perform three individual labeling reactions using 1 mg of IgG or similar protein quantities. Thermo Fisher For information 815-968-0747 www.thermo.com/pierce Laser Color Selection The In Tune laser system offers the ability to select all wavelengths from 488 nm to 640 nm for use with the LSM 710 laser scanning microscope. The explosion of fluorescent dyes has opened opportunities for researchers, but their use has been limited by the requirement that the microscope system be equipped with an appropriate excitation laser. The In Tune system is meant to address this need by allowing cell biologists, physiologists, and researchers in biology, medicine, and biophysics to perform these fluorescence measurements. Whatever the excitation wavelength required, In Tune can match it perfectly to enable the use of new dyes in intensity or lifetime imaging experiments. Further expanding its range, In Tune can be used alongside other system lasers, from ultraviolet to far red. Carl Zeiss For information 800-233-2343 www.zeiss.com/micro Fluorescing Stem Cells Three new MilliTrace stem cell lines express green fluorescent protein (GFP) under the control of various embryonic and neural stem cell markers. With their brilliant green glow, these cells offer scientists a quick, noninvasive way to monitor the behavior of specific stem cell populations as they proliferate, migrate, and differentiate into various lineages. The new cell lines feature GFP reporters under the control of nanog (mouse embryonic stem cells) or nestin and Sox-2 (human neural stem cells) transcription factors. The loss of these stem cell markers during differentiation causes down-regulation of the GFP, making it easy to spot cells that have not differentiated. Millipore For information 800-548-7853 www.millipore.com/stemcells Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier. www.sciencemag.org/products SCIENCE VOL 326 2 OCTOBER 2009 157

Youcandeliver.Wecanhelp. Invitrogen transfection solutions First and foremost, it works; second, it s convenient; and third, it s just a great machine. Dana Yoo Osiris Therapeutics, Inc. InvitrogencanhelpyoudeliverDNAorsiRNAintovirtuallyanycelltype.Infact,the Neon Transfection System our next-generation electroporation device can successfully transfect even the most difficult-to-transfect primary and stem cells. Achieve 90% transfection efficiency and more than 80% viability in many mammalian cells Transfect DNA or sirna into as few as 20,000 cells Benefit from exceptional value a fast and simple workflow at half the initial purchase price compared to similar electroporation devices Visit www.invitrogen.com/neon4me for details and to request a demonstration. 2009 Life Technologies Corporation. All rights reserved.