Cell Discovery 360: Explore more possibilities.

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1 Cell Discovery 360: Explore more possibilities. Flexible solutions for the BioPharma laboratory Blood Banking Capillary Electrophoresis Centrifugation Flow Cytometry Genomics Lab Automation Lab Tools Particle Characterization BR-14650A

2 A trusted partner through the continuum of the Biopharmaceutical process. Researching, discovering, developing and producing one new pharmaceutical drug is a long and arduous process which can take anywhere from years and cost billions of dollars. But, what if that process could be streamlined by working with a company who is a leading provider of research instrumentation, automation platforms and antibodies? Beckman Coulter can collaborate with you to understand your specific drug discovery requirements and create flexible workflow solutions that meet your evolving needs. You not only get state-of-theart technology, but you also get a partner who is there for the long term to make sure your entire system works well and finetunes it so you get increasingly better performance over time. We integrate a variety of specialized reagents, instrumentation and software to help you automate, standardize and simplify the biopharmaceutical phases of drug discovery and development. No other company offers you more comprehensive solutions for your drug research, discovery, development and production cycles than Beckman Coulter. Explore the possibilities with our Cell Discovery 360.

3 Basic Life Science & Drug Research The discovery of a new pharmaceutical-grade drug begins with a group of scientists, chemists or pharmacologists who have identified factors such as cellular and genetic parameters that play a role in stem cell research or to a specific disease. Beckman Coulter offers a vast array of hardware, software and consumables that help the researcher identify and analyze each aspect of the Drug Research Process. From discovery solutions for genetic analysis and protein studies; to cellular analysis to isolate and characterize cellular and phenotypic events; single cell resolution; and cell signaling applications, we provide solutions that address your needs. In addition, we offer automated and high-throughput solutions to standardize your process and increase laboratory efficiency and productivity with our life science automation products. With Beckman Coulter s expansive portfolio you get multiple solutions for your biopharmaceutical laboratory s research needs. Cell Isolation and Preparation MoFlo XDP* Cell Sorter MoFlo Astrios* Cell Sorter Optima L-XP Series Ultracentrifuges Single Cell PCR AmpliGrid System Gene Expression Analysis GeXP** Genetic Analysis System Automated Cell Cultivation Biomek** Automated Workstations Quantum** Cell Expansion System Vi-CELL** Series Viability Analyzers High-Content Analysis icys and icyte Imaging Cytometers Gallios Flow Cytometer CyAn ADP Flow Cytometer Analysis Software Kaluza Analysis Software Reagents Antibodies Cell Signaling Mouse Tandems Life Science Automation Biomek 3000, NX p, FX p Workstations Biomek Antibody Cocktail Preparation

4 Drug Discovery The drug discovery process begins with cells or compounds that have been selected for investigation due to the fact that they may have an interaction with a desired drug target. Positive results from a primary screen are tested further to ensure that the desired change is elicited in the intended cells without producing toxic side effects. Beckman Coulter can help standardize this process with its wide range of cell-based analysis and screening workflow solutions for drug discovery. Screening methodologies have extended beyond traditional biochemical tests to include genetic-based manipulations in the pursuit of the next blockbuster drug. RNA interference (RNAi) has been established as the leading functional genomic tool during the last few years. Our expertise covers all aspects of sirna screening, from library handling, transfection, and reinfection through readout technologies. We can automate the cellular handling for your RNAi process on our Biomek Liquid Handling Workstations, delivering cellular solutions to fit your workflow. For your secondary screening needs, not only do we provide a wide breadth of liquid handling platforms to streamline your high-throughput screening, but we also offer flexible solutions for high-content screening such as the icyte Automated Imaging Cytometer. icyte offers automated high-content cellular analysis capabilities in a high-throughput microtiter plate format that can precisely measure cellular DNA content, which is essential in toxicological studies, helping the researcher meet the challenges of the drug discovery process. We integrate novel cell-based assays, reagents, instrumentation and bioinformatics software, which is important during lead optimization to measure the potency, specificity and toxicity of compounds. For multiparametric cell-based screening, our highthroughput flow cytometers are the ideal solution. You get analysis speeds of 70,000 events with sampling times of ~ 2.5 minutes for 96-well plates and ~ 10 minutes for a 384-well plate in combination with a HyperCyt Autosampler. In addition, our Biomek Liquid Handling Workstations can automate your sample preparation tasks and streamline your workflow processes. High-Throughput Flow Cytometry Gallios Flow Cytometer HyperCyt Autosampler CyAn ADP Flow Cytometer High-Content Laser Scanning Cytometry icyte Automated Imaging Cytometer Liquid Handling Workstations Biomek NX p Biomek FX p BioRAPTR FRD** Reagents Tetramers

5 Drug Development Sequential steps are necessary for the drug development process. Detecting liability issues is one of the key phases of drug development. By synthesizing a new chemical or producing a new biological compound, the researcher can test the effectiveness of the potential drug in terms of safety, tolerability and toxicity. Beckman Coulter offers many products from instrumentation to software and reagents to help the researcher with this process. By integrating HyperCyt with the CyAn ADP or the Gallios Flow Cytometer, you get high-throughput with accurate, costefficient ADME/Tox screening and cytotoxicity profiling. In addition, HyperCyt can be integrated with robotic plate loaders with optional automation interface software. You get speed and automation all in one package. Optimize the cell cultivation process and analyze multiple experiments simultaneously. Use our Quantum Cell Expansion System to harvest cells at predictable harvest rates with reduced risk of contamination due to its functionally closed system design. Another important instrument for drug development studies is the laser scanning cytometer like our icyte Automated Imaging Cytometer. It can analyze small cell samples that cannot be reasonably analyzed by traditional flow cytometry. Just another way that Beckman Coulter offers flexible workflow solutions for your pharmaceutical laboratory. ADME/Tox HyperCyt and CyAn ADP Flow Cytometer HyperCyt and Gallios Flow Cytometer Cell Line Optimization Integrated Biomek Workstations AAO for BioRAPTR Software Vi-CELL Series Viability Analyzers icyte Automated Imaging Cytometer Cell Expansion Quantum Cell Expansion System

6 Drug Production & Quality Control The challenge for drug production is to scale up by defining and controlling processes capable of producing similar products initially developed at a much smaller scale. In other words, a robust set of parameters is necessary in order to transfer the results that occurred in an R&D laboratory setting to mass production. However, it may include a need for simply enlarging the output by increasing the speed or quantity, which can then be used for clinical testing and trials. A well-defined process is necessary to generate a perfect product in the laboratory as well as the pilot scale to assure quality tests during the production phase. Beckman Coulter offers a variety of solutions for your production, quality control and scale-up needs. For example, our PA 800 plus Pharmaceutical Analysis System is specifically designed for the biopharmaceutical laboratory. It integrates quantitative, qualitative and automated solutions for protein purity, charge isoform distribution and glycan analysis. It addresses the needs of analysts who handle therapeutic proteins by providing robust analytical tools for the development and quality control of therapeutic proteins. The Quantum Cell Expansion System is the latest technology available for automated cell expansion. It is a functionally closed, self-contained, fully automated cell expansion system. With its unique hollow fiber bioreactor and incubator system design, you achieve predictable harvest rates. The system is ideal for scaling-up cell manufacturing. Total Beckman Coulter offers a variety of solutions for your production, quality control and scale-up needs. PA 800 plus** Pharmaceutical Analysis System Quantum Cell Expansion System Customer Support Global support is yet another benefit of our Cell Discovery 360 workflow solutions. With Call Centers located around the world, Beckman Coulter provides online help and expert field consultants to keep your biopharmaceutical laboratory running smoothly. And that s only the beginning. With our PROService remote diagnostic capabilities, you ll get highly qualified Beckman Coulter service and support personnel to review your instrumentation s status, troubleshoot any issues, and resolve any problems remotely, so your instrumentation is working at peak performance at all times. Contact your local Beckman Coulter representative to find out how you can streamline your workflow with our customized solutions for your biopharmaceutical laboratory.

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8 AmpliGrid, AmpliSpeed, CyAn, Gallios, HyperCyt, icys, icyte, MoFlo Astrios, MoFlo XDP and Kaluza are for Research Use Only. Not for use in diagnostic procedures. * MoFlo Astrios and MoFlo XDP are class 1 lasers. ** Biomek systems, GeXP, BioRAPTR, Vi-CELL and PA800 are for Laboratory Use Only. Not for use in diagnostic procedures. Quantum is pending submission and clearance by regulatory agencies in Canada, France, Germany, Japan and Sweden. Quantum is a trademark or registered trademark of CaridianBCT, Inc. in the United States and in several other jurisdictions. All other markets Quantum is a medical device. icyte Automated Imaging Cytometer and icys Research Imaging Cytometer are registered trademarks of the CompuCyte Corporation. HyperCyt is a registered trademark of Intellicyt. HyperCyt and Gallios integration is in development. Beckman Coulter, the stylized logo, AmpliSpeed, AmpliGrid, Biomek, BioRAPTR, CyAn, MoFlo, and Vi-CELL are registered trademarks of Beckman Coulter, Inc. Astrios, Gallios, Kaluza and Optima are trademarks of Beckman Coulter, Inc. Space for FSC Logo Printed with soy ink For Beckman Coulter s worldwide office locations and phone numbers, please visit Contact Us at B K-DG 2011 Beckman Coulter, Inc. PRINTED IN U.S.A.