Commercialization of Antimicrobial Copper Harold T. Michels, PhD. Sr. VP Technology and Technical Services Copper Development Association, US

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Commercialization of Antimicrobial Copper Harold T. Michels, PhD. Sr. VP Technology and Technical Services Copper Development Association, US Medica Dusseldorf

Agenda Overview of Copper and its Alloys Manufacturing Benefits of Copper Alloys Commercializing Antimicrobial Copper in the US Antimicrobial Copper Supply Chain: What s Next? 2

Overview of Copper and its Alloys 3

Copper: Naturally occurring element 4

Copper: Basic material properties Ductile Malleable High thermal Conductivity High electrical Conductivity Easily alloyed Good corrosion resistance Readily available Highly recyclable Antifouling Antimicrobial 5

Copper can be easily combined with many other elements to form alloys Al Cd Cr Si Mn O Be Ti Ni Zr P Zn Sn Fe Zn Al Ni Si Sn Sn CU Ni As Al Zn Pb Te Se Sn Al Si S Bi Ag Pb P Sb Mn Fe 6

Over 500 commercially available copper alloys provide an unmatched combination of properties Color Machinability Zn Pb Al Sn S Te Ni Zn Bi Se Strength Al Cd Cr Si Mn O Be Ti Ni Zr P Zn Sn Fe Sn Cd CU Al Si Ag Pb P Ni Si Sb Sn As Al Mn Corrosion Resistance Fe Wear Resistance 7

Example alloys 8

Copper alloys are readily available in a wide variety of shapes and semi-fabricated forms 9

Manufacturing Benefits of Copper Alloys 10

Ease of Fabrication: Copper alloys are malleable, highly machinable, readily joined... 11

Excellent combinations of strength, ductility, and corrosion resistance 12

100% recyclable 13

Many tarnish resistant alloy options available 14

Copper alloys are the third most important group of commercial metals behind iron/steel and aluminum 15

Antimicrobial Copper designates copper alloys used for touch surface applications to kill human pathogens Minimum 60% copper content No additional processing or special treatment required 16

Commercializing Antimicrobial Copper in the US 17

Challenge: Manufacturing benefits of copper alloys were well understood, but not for touch surface applications Stainless steel, plastic, wood are the standard materials, but they do not kill pathogens 18

Supply Chain: Initial barriers No commercial products available Manufacturers unfamiliar with copper alloys Unusual geometries and applications for metals High raw material cost compared to stainless steel Short and long term aesthetic concerns 19

US Clinical Trials Products, 2008: Prototypes Bed rails Nurse s call device Data Input Monitor Mouse IV Pole Over-bed tray table Visitor s chair Laptop 20

Growing awareness stimulated supply chain activity US clinical trials engaged several manufacturers Increased media attention on HAIs increased awareness Copper industry awareness campaign fueled interest Manufacturers began experimenting with copper alloys Material suppliers helped address manufacturing concerns 21

Copper alloy components can cost less to manufacture Barbed hose fitting case study Stainless Steel Brass Rod Cost 2 /kg 8 /kg Value of Scrap 0.5 /kg 7.0 /kg Time T x 5 T Component Cost 6.90 1.47 Additional benefit: longer tool life with Brass 22

Manufacturing and health benefits addressed cost concerns Material cost is a small percentage of total manufacturing cost Copper alloys have higher manufacturing efficiency compared to many other materials Copper alloy products can command a premium for health benefits Antimicrobial Copper is the only alloy system with a US EPA public health registration 23

Manufacturers progressed through the copper alloy learning curve Bending Welding Stamping Deep-drawing Casting Forging Finishing 24

Ronald McDonald House demonstration project accelerated commercialization Significant orders enticed manufacturers to scale up operations Industry funding supported manufacturers investments Media attention helped manufacturers realize market potential 25

Ronald McDonald House Components: Before Antimicrobial Copper retrofit Locksets Sinks & Faucets Tables Cabinet Pulls Visitor Chairs Stair Railings 26

Ronald McDonald House Components: After Antimicrobial Copper retrofit Locksets Sinks & Faucets Tables Cabinet Pulls Visitor Chairs Stair Railings 27

Average Viable Bacteria / 100 cm2 Ronald McDonald House data validated efficacy 8,000 7,000 6,000 Non-Copper Items-Averages 5,000 Copper Items-Averages 4,000 3,000 2,000 1,000 0 Gadsden St. Stairwell Rails Center Stairwell Rails Barre St. Stairwell Rails Upstairs Rails Chairs Kitchen Table Kitchen Knobs Pantry Pulls Guest Sink Area Bathroom Guestroom Door Levers Door Levers 28 10 weeks of sampling copper surfaces compared to 10 weeks of sampling pre-copper surfaces

Growing demand supported commercialization 15 US Manufacturers launched commercial Antimicrobial Copper products in the US market to date A.T. Cross Black Iron Strength Colonial Bronze Cooper Industries Denise Siegel Bronze Elkay Commercial Products Frigo Design Just Manufacturing Larco Midbrook Medical NuAire Operator Interface Technology (OIT) Pedigo Products R.B. Wagner Rocky Mountain Hardware More close to launch 29

Downstream marketing increased exposure Component makers launched sophisticated marketing campaigns 30

Antimicrobial Copper Supply Chain: What s Next? 31

Published US clinical trial results are supporting the business case 1 st study to show surfaces can reduce infections 7% of hospital room surface area converted to copper 83% less bacteria on copper surfaces 50% of infections or more caused by environment 58% fewer infections in copper rooms 32

Publicized installations around the world are driving demand Roberto del Rio Pediatric Hospital / Santiago, Chile Aghia Sofia Children's Hospital / Greece Bueras Metro Station / Santiago, Chile Centre Inter Générationnel Multi Accueil / France Craigavon Area Hospital / Northern Ireland Sheffield Teaching Hospitals NHS Trust / United Kingdom Lewis County Hospital / Lowville, NY Jason s Deli / 10 US locations and counting Congonhas International Airport / Sao Paulo, Brazil Cancer Treatment Centers for America / Atlanta, GA, Phoenix, AZ And Many More 33

The portfolio of commercially available Antimicrobial Copper products is growing daily 34

Thank you Harold T. Michels, PhD Copper Development Association, US 212-251-7224 harold.michels@copperalliance.us 35