ÖZGEÇMİŞ Temmuz, 2014 Şükrü Güleç, PhD. Telefon: 02327506283 E-mail: sukrugulec@iyte.edu.tr - sukrugulec@gmail.com Dogum Tarihi: 07/10/1980 Medeni Hali: Evli Eğitim Durumu: 2013-2014 Doktora Sonrası Araştırmacı, Food Science and Human Nutrition, 2009-2013 Doktora Öğrencisi, Nutritional Science Inter Discipliner Program 2006-2008 Biyolog Araştırmacı, Dept. of Food Science and Human Nutrition, 2004-2006 Yüksek Lisans, Ankara Üniversitesi Biyoteknoloji Enstitüsü, Moleküler Patolji & Genetik Laboratuvarı, Ankara Üniversitesi Tıp Fakültesi 2000-2004 Lisans, Ankara Üniversitesi, Biyoloji Bölümü Akademik Ünvanlar 2014- Gıda Mühendisliği Bölüm Başkan Yarımcılığı 2014- Yardımcı Doçent Doktor, İzmir Yüksek Teknoloji Enstitüsü Gıda Mühendisliği Hakemli Dergilerde Yayınlanmış Çalışmalar: 1. Sukru Gulec, James F. Collins. Silencing of The Menkes Copper-Transporting Atpase (Atp7a) Gene Increases Cyclin D1 Protein Expressıon and Impairs Proliferation of Rat Intestinal Epithelial (IEC-6) Cells. 2014, J Trace Elem Med Biol. (İncelenme aşamasında) 1
2. Gulec S, Collins JF. Molecular Mediators Governing Iron-Copper Interactions. Annu Rev Nutr. 2014 Jun 2. [Epub ahead of print]. 3. Gulec S, Anderson GJ, Collins JF. Mechanistic and Regulatory Aspects of Intestinal Iron Absorption. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 3. pii: ajpgi.00348.2013. [Epub ahead of print]. 4. Gulec S, Collins JF. Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). 2013, The American Journal of Nutrition (Epub ahead of print). 5. Gulec S, Collins JF. Investigation of Iron Metabolism in Mice Expressing a Mutant Menke s Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; Mo Br/y ). 2013, PlosOne; Jun 11;8(6). 6. Afife Karabiyik, Erkan Yilmaz, Sukru Gulec, Ibrahim Haznedaroglu, Nejat Akar. Dual Diverse Dynamic Reversible Actions of Ankaferd on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS. 2012, Turkish Journal of Hematology; DOI: 10.5152/tjh.2011.41. 7. Erkan Yılmaz, Sukru Gulec, Didem Torun, İbrahim Celalettin Haznedaroğlu, Nejat Akar. The effects of Ankaferd Blood Stopper on Transcription Factors in HUVEC and the Erythrocyte Protein Profile. 2011, Turkish J Hematol.; 28(4): 276-285. 8. Karabiyik A, Gulec S, Yilmaz E, Haznedaroglu I, Akar N. Reversible Protease-Activated Receptor I Downregulation Mediated by Ankaferd Blood Stopper Inducible With Lipopolysaccharides Inside the Human Umbilical Vein Endothelial Cells. 2011, Clin Appl Thromb Hemost; 17(6);E165-70. 9. Hu Z, Gulec S, Collins JF. Cross-species Comparison of Genomewide Gene Expression Profiles Reveals Induction of Hypoxia-Inducible Factor-Responsive Genes in Iron-Deprived Intestinal Epithelial Cells. 2010, Am J Physiol Cell Physiol.; 299(5):C930-8. 10. Fikret Aydemir, Supak Jenkitkasemwong, Sukru Gulec, and Mitchell D. Knutson. Iron Loading Induces Ferroportin Gene (Slc40a1) Transcription in Macrophage. 2009, The Journal of Nutrition; 139(3):434-8. 11. Tim Hofer, Emanuele Marzetti, Jinze Xu, Arnold Y. Seo, Sukru Gulec, Mitchell D. Knutson, Christiaan Leeuwenburgh and Esther E. Dupont-Versteegden. Increased RNA Oxidative Damage and Iron Content in Skeletal Muscle with Aging and Tissue Atrophy. 2008, Experimental Gerontology; 43(6):563-70. 12. Sukru Gulec, Ahmet Ruchan Akar, Nejat Akar. MEF2A Sequence Variants in Turkish Population. 2008, Clin Appl Thrombosis Hemostasis; 14(4):465-7. 13. Eroglu A, Gulec S, Akar N. Vascular Endothelial Growth Factor C936T Polymorphism in cancer patients with thrombosis. 2007, American J.Hematology; 82(2):174. 2
14. Eroglu A, Gulec S, Kurtman C, Cam R, Akar N. Vascular Endothelial Growth Factor 936 C/T Polymorphism in cancer Patients. 2006, Annals of Oncology; 17(9):1467-8. Sözlü Sunum ve Poster: 1. Silencing of The Menkes Copper-Transporting Atpase (Atp7a) in Rat Intestinal Epithelial (IEC-6) Cells Increases Cyclin D1 Protein Expressıon and Impairs Growth. James F. Collins, Caglar Doguer, Sukru Gulec. The 15 th International Symposium on Trace Elements in Man and Animals (TEMA15) 2014. Orlando, Florida. (Poster). 2. CaCo-2 Cells Contain a Functional Ferroxidase That Is Not Hephaestin. James F. Collins, Sukru Gulec, Caglar Doguer. The 15 th International Symposium on Trace Elements in Man and Animals (TEMA15) 2014. Orlando, Florida. (Poster). 3. Sukru Gulec, Caglar Doguer, James F. Collins. Knock-Down of Menkes Copper- Transporting ATPase (ATP7A) in Rat Intestinal Endothelial (IEC-6) Cells Increases Ferroportin 1 (FPN1) Expression and Enhances Iron Transport. International BioIron Society (IBIS) 2013, London, United Kingdom (Poster Sunumu). Published: American Journal of Hematology, 88(5), E240-E241 4. S. Gulec, J. Collins, Silencing of the Menkes Copper-Transporting ATPase (Atp7a) in Intestinal Epithelial Cells Impairs Cell Growth and Cell Cycle Control. Experimental Biology 2013, Boston, MA (Sözlü Sunum). Published: FASEB Journal, 27:223.5 5. S. Gulec, J. Collins. Iron Metabolism in a Rodent Model of Menkes Disease (Brindled Mice). Experimental Biology 2013, Boston, MA (Poster Sunumu). Published: FASEB Journal, 27:634.2 6. S. Gulec, J. Collins. Knock-Down of Atp7a Expression Reduces Hephaestin Expression and Activity in A Rat Intestinal Epithelial Cell Line (IEC-6). Experimental Biology 2013, Boston, MA (Poster Sunumu). Published: FASEB Journal, 27:Ib293 7. S. Gulec, P. Ranganathan, Y. Lu, J. Collins. Physiologic Role of the Menkes Copper ATPase (Atp7a) in Intestinal Iron Transport. Experimental Biology 2012, San Diego, California (Sözlü Sunum ve Poster Sunumu). Published: FASEB Journal, 26:641.22 8. James F. Collins, Sukru Gulec, Zihua Hu. Hypoxia Inducible Factor (HIF) Responsive Genes Form the Core Transcriptional Response of the Intestinal Epithelium During Iron Deficiency. Digestive Disease Week, New Orleans 2010, LA (Poster Sunumu). Published: Gastroenterology, 138(5), S-316 3
9. Afife Karabiyik, Erkan Yılmaz, Sukru Gulec, Ibrahim Haznedaroglu, Nejat Akar. Reversible Actions of Ankaferd on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS. 21 st International Congress on Thrombosis 2010, Milan, Italy (Poster Sunumu). 10. H. Nam, S. Gulec, M.D. Knutson. Dietary iron deficiency increases Zip14 expression in rats. Experimental Biology 2008, San Diego, California (Poster Sunumu). Published: FASEB Journal, 22:155.4 11. H. Nam, N. Zhao, S. Gulec, J. P. Liuzzi, M.D. Knutson. Effects of Cellular Iron Deficiency and Phlebotomy on Zip14 Expression. International BioIron Society (IBIS), Biennial World Meeting 2007, Kyoto, Japan (Poster Sunumu). Published: American Journal of Hematology, 82(6), 543-544 12. Gulec S, Akar R, Korkmaz O, Akar N. MEF2A sequence variants in Turkish People. International Congress on Thrombosis 2006, Tel-Aviv, Israel (Sözlü Sunum). 13. Eroglu A, Gulec S, Kurtman C, Cam R, Akar N. Vascular Endothelial Growth Factor 936 C/T Polymorphism in Cancer Patients. 6 th National Thrombosis, Homeostasis and Angiology Congress 2006, Izmir, Turkey (Poster Sunumu). Üyelikler - American Society for Nutrition (ASN) (2010- ) Katıldığı Seminer ve Kurslar - Teacher Collage course: Teacher developing a teaching philosophy to designing effective assessments and reflecting on practice, UF - Grand Writing seminar, The Institute of Food and Agricultural Science, UF - Basic Radiation safety, Division of Environmental Health and Safety, UF Firmalar ile Yapılan Ortak Çalışmalar - Testing of SG gas infused water on intestinal nutrient absorption (2010-2011): Exploration of the effects of Watt-Ahh, an aquanew water and the SG gas infusion process on the transport of vitamin C and iron by differentiated monolayers of human intestinal epithelial (CaCo-2) cells. Firma: Watt-Ahh An AquaNew Water L.L.C. (http://www.aquanew.com/index.shtml) 4
Burslar ve Ödüller - Öğretim Görevlisi Bursu (2012-2013), Food Science and Human Nutrition, University of Florida - Araştırma Görevlisi Bursu (2009-2012), Food Science and Human Nutrition, University of Florida - Finalist, American Society for Nutrition s Graduate Student Research Awards Competition, 2012. Not: Direk ve tam Türkçe karşılığı bulunamayan proje isimleri ve kelimeler ingilizce olarak kullanılmıştır. 5