Nanomedicine in Horizon 2020
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1 Nanomedicine in Horizon 2020 Heico FRIMA Programme Officer European Commission Directorate-General for Research & Directorate D: Key Enabling Technologies ETPN Annual Event 2014 San Sebastian October 15, 2014 Research and
2 EU Horizon link to the European Technology Platform for Nanomedicine (ETP-N) - ETP-N: one of the 38 ETPs that are recognised in Horizon ETP-N gives advice to the EC on research & innovation priorities and policies, through Vision Paper (2005), Strategic Research and Agendas, Roadmaps, White Papers,.. - Encouraging industry participation in Horizon Fostering networking; 150 member organisations - Working Groups on priority areas - ETP-N: White paper "Contribution of Nanomedicine to H2020" - - Horizon 2020: ETP-N emphasis is on translation e.g. Translation Advisory Board, Pilot Manufacturing, NanoCharacterisation Lab Policy Research and
3 Nanomedicine well established in EU FP7 ( ) FP7 NMP 86 Projects with ~ 446 M EU funding; (involving ~ 246 SMEs) Health programme 12 Projects with ~ 53 M EU funding Also projects funded in: European Research Council, ERC (Frontier research) ICT (Micro-Nano-Bio-Systems) PEOPLE (Marie-Curie Training bursaries and training networks) EuroNanoMed (ERANET, trans-national projects) EuroSTARS (Eureka ~ EU) Policy Research and
4 Benefits of the nano-approach being confirmed - - FP7 nanomedicine RTD has been mainly on feasibility and preclinical work; considerable EU expertise has been built-up. - - Focus has been on: Novel drug delivery methods / targeted nanopharmaceuticals - Ultra-sensitive diagnostic methods & improved medical imaging Biomaterials & regenerative medicine - Micro-nano-bio-systems (e.g. for intelligent implants) - Projects funded cover a wide range of diseases Policy Research and
5 Nanomedicine progression - - Common understanding between Nanotechnology- and Medical communities (role of CLINAM) - - Increased understanding of biological and cell molecular processes -> more effective RTD processes -> personalisation; - - Medical doctors getting interested in the nano-approach. Several nano-projects coordinated by MD Specialists (SaveMe, NAMDIATREAM, CosmoPHOS-nano, NANOCI); - Industrial interest is also strongly increasing. - - Novel nano-technological platforms will enable similar approaches to therapy and diagnostics of different diseases. Policy Research and
6 EU FP7/Horizon link to the European Technology Platform for Nanomedicine (ETP-N) - Successful translation of research results into medical products has been identified as one of the major challenges for the sector. - Major hurdles were identified between the Proof of Concept (PoC) (TRL4) - and the clinical PoC (TRL7), including difficulties of - - access to capital, - - up-scaling of manufacturing and characterisation, - - meeting regulatory requirements and clinical needs and - - reimbursement for innovative therapies from the public sector and health insurance companies. More than 700 industrial players and SMEs in Europe with a direct link or activities in the field of nanomedicine, together with nearly 1000 academic laboratories or research centres. Policy Research and
7 A new generation of research projects in Horizon Following strong progress of nanomedicine R&D in past ten years - Translational nanomedicine projects, with emphasis on pilot activities for robust manufacturing & characterisation of nano-medicines, late preclinical and clinical testing, on meeting regulatory aspects (EMA/FDA). Horizon 2020 provides opportunites for these pilot activities, clinical trials, and other support for translation. - Pre-clinical nanomedicine research can take place especially in the LEIT programme clinical research in the Health programme. - Call for Novel infrastructure activity for characterisation of nanomedicines in the Infrastructure programme. - Novel nanomedicine concepts can also be proposed, to the European Research Council (ERC), FETOpen, Marie-Curie Training Networks - Specific Actions for SME's - Access to Capital (with EIB) Policy Research and
8 Example - combining several KETs for advanced products Societal Challenge Advanced materials Microelectronics Nanotechnologies New nanotechnologybased diagnostics New target drug delivery and release Regenerative medecine Photonics Biotechnologies Policy Research and
9 Horizon 2020 Total indicative budget: 77.0 billion * Excellent science European Research Council Future and EmergingTechnologies Marie Curie actions Research infrastructures Indicative Budget: 24.4 billion * Industrial leadership Leadership in enabling and industrial technologies Access to risk finance in SMEs Indicative Budget: 17.0 billion * Societal challenges Health, demographic change and wellbeing & Innovative Medicines Initiative IMI2 (Pharmaceutics, EFPIA + EC) Food security, agriculture, marine and maritime research and the bioeconomy Energy Transport Climate action, resource efficiency and raw materials * , actual budget (indicative) Includes 5.9 billion for "widening participaton", "science with and for society", JRC and EIT not shown in three priorities above Policy Research and Inclusive, innovative and reflective societies Secure societies Indicative Budget: 29.7 billion *
10 Example 1: LEIT Call for Nanotechnology, Advanced Materials, Production Technologies and Biotechnology (NMPB) Nanotechnology and Advanced Materials for more effective Healthcare Topic code Topic title Type of Action NMP Scale-up of nanopharmaceuticals production Call is closed NMP Networking of SMEs in the nano-biomedical sector Call is closed CSA NMP Biomaterials for the treatment of Diabetes Mellitus Call is closed NMP Nanomedicine therapy for cancer Budget ~ 15 Mio Two Stage: deadline Stage 1: 26 March 2015 NMP Biomaterials for treatment and prevention of Alzheimer's disease Budget ~ 15 Mio Two stage: deadline stage 1: 26 March 2015 Policy Research and
11 Example 2: Call Societal Challenge - HEALTH Programme Personalising Health and Care (PHC) PHC PHC PHC PHC Development of new diagnostic tools and technologies: in vitro devices, assays and platforms. Call closed Development of new diagnostic tools and technologies: in-vvo imaging technologies Tools and technologies for advanced therapies - two stage proposal procedure - deadline stage 1: 14 Oct budget 306 mi Clinical research on regenerative medicine - single stage - deadline Emphasis is on clinical applications / clinical testing Policy Research and
12 ETP-N Proposal Topic in H2020-INFRAIA -2014/2015 Integrating and opening research infrastructures of European interest Call closed Sept 2, 2014 EU-NCL: European Nanomedicine Characterisation Laboratory The objective is: - to reach a level of international excellence in nanomedicine characterization for all medical indications, and - make it accessible to all organisations developing candidate nanomedicines prior to their submission to the regulatory agencies in order to get the approval for clinical trials and later the marketing authorization. Policy Research and 12
13 Planning actions Strategic Research Agenda & priority call topics update for Work Programme Start of Translation Advisory Board, pilot line projects,.. New Commission Juncker - priority on investment for growth and jobs, leadership in health research Reflections on a new Public-Private Partnerships (PPP) Policy Research and 13
14 Find out more on Horizon 2020: Participant Portal: /page/home Information Days / National Contact Points / Helpdesks.. Thank you for your attention Policy Research and
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