ParaVision 6. Innovation with Integrity. The Next Generation of MR Acquisition and Processing for Preclinical and Material Research.

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1 ParaVision 6 The Next Generation of MR Acquisition and Processing for Preclinical and Material Research Innovation with Integrity Preclinical MRI

2 A new standard in Preclinical Imaging ParaVision sets a new standard in preclinical imaging software. Its unique features enable easy and accelerated workflow for routine users and experts. With its well structured library of in vivo optimized protocols, its sophisticated image processing, visualization and data analysis features, ParaVision 6 ensures maximum productivity enhancing biomedical and pharmaceutical research. The ParaVision 6 workflow is designed for optimal operation of MRI systems and is powered by the new electronic AVANCE III HD MRI platform. This now enables automatic hardware recognition for fast and easy setup, integrated dynamic realtime optimization and adjustment of experimental parameters during scanning, dynamic shimming and fast 64 bit multi-core image reconstruction for high resolution 3D imaging results. All application packages benefit from ParaVision s new fully searchable, easy to use data base, network data management, and new archiving capabilities enabling the connection of multiple ParaVision workstations and DICOM server archiving. ParaVision 6 also supports and facilitates data exchange with other imaging modalities in your lab. ParaVision 6 highlights New and accelerated, intuitive workflow Ready-to-use protocols and scan programs Active method conflict handling Automatic hardware recognition Real-time optimization during scanning On-the-fly RF-pulse calculation In-line navigator-based image reconstruction Fast 64 bit multi core image reconstruction for high resolution 3D Fully searchable data base, network data management

3 Unsurpassed Productivity A new and convenient interface for an improved users experience Optimized Workflow The ParaVision 6 user interface of dynamic context menus, cards and icons offers instant access to the most commonly used imaging protocols and processing tools. Unmatched portfolio of application packages ParaVision 6 provides various dedicated, optional preclinical imaging packages for a wide range of animal MR imaging and spectroscopy applications. All benefit from the new accelerated workflow incorporating ready-to-use protocols and scan programs combined with interactive method and parameter for conflict handling. ParaVision application packages include: Cardiology Diffusion Angiography Perfusion Spectroscopy fmri and DCE Relaxation Short TE Imaging Method development framework ParaVision 6 measurment queue for a fully automated scanning of studies Automation For maximized throughput ParaVision 6 provides fully automated acquisition and processing, including scan queueing. This productivity tool excels whenever high animal throughput accrues, or when your MRI system is accessed by many users.

4 Comprehensive Tool Portfolio 3D Visualization and Analysis 3D data visualization and analysis tools extend basic viewing functionality: 3D interactive viewing Maximum intensity projection (MIP) Multi-planar secondary image reconstruction (MPR) Segmentation Surface rendering Movie generation Parallel Transmit Acquisition functionality for parallel transmit imaging techniques including: Support of multi-channel parallel transmit RFpulses in all methods Optimized phase calibration for homogeneous excitation with multi-element RF transmitter coils Parallel transmit template methods and protocols Parallel Imaging and Reconstruction Parallel imaging and reconstruction techniques including: Accelerated parallel image acquisition GRAPPA based image reconstruction 3D Evaluation Tools includes interactive magnification in real time, quantitative ROI analysis, geometric measurements, digital filtering, movie display of image sequences, and 3D secondary reconstruction of orthogonal planes. 3D imaging with 3D image processing 3D data evaluation and visualization e.g. multi planar reconstruction MR angiography Image algebra and image sequence analysis Network data management and archiving with ParaVision 6

5 Method Development Framework A transparent method-programming framework including powerful tools, access to method toolboxes and method source code enable easy implementation of image acquisition and dedicated reconstruction techniques with only basic programming knowledge. Network Data Management and Archiving The database browser functionality enables network data transfer between multiple ParaVision workstations, facilitates data exchange with other imaging modalities in your lab and provides archiving on DVD and to DICOM server. DTI Evaluation 3D region growing for signal masking 2D & 3D visualization of composite images DTI-EPI supporting k-space trajectory based reconstruction Calculation module to derive scalar and directional information Visualization of direction-encoded color-maps in 2D and 3D together with morphological reference images Transparency modulation by fractional anisotropy images Arbitrary composition schemes and color coding capabilities Multimodal Data Import Import DICOM data to ParaVision from the following modalities: Magnetic Resonance Imaging (MRI) Positron Emission Tomography (PET) Computer Assisted Tomography (CT) Magnetic Particle Imaging (MPI) Single Positron Emission Computed Tomography (SPECT) Project Planning Off-line registration and preparation from a remote processing workplace, including: Subjects Sessions, studies, scans and projects Protocols Scan programs

6 Application Packages Cardiology The CARDIO application package includes all methods and software tools required for triggerd or self-gated cardiac imaging with black blood, bright blood or tagging contrast. Flow-compensated fast gradient echo imaging Self-gated cardiac imaging Self-gated cardiac image reconstruction Diffusion The DIFFUSION application package includes all methods, protocols, and software tool required for diffusion weighted or diffusion tensor imaging. Spin echo based diffusion tensor imaging Echo planar based diffusion tensor imaging Spiral based diffusion tensor imaging DTI analysis and visualization Angiography The ANGIOGRAPHY application package includes all methods, protocols, and software tool required for angiography and velocity imaging. Flow-compensated fast gradient echo imaging Phase contrast angiography Quantitative flow mapping Perfusion The PASL application package includes methods and software tools to measure and reconstruct CBF parameter maps using pulsed arterial spin-labeling techniques. Fast spin echo perfusion imaging Echo planar perfusion imaging CBF parameter map calculation software

7 fmri The fmri and DCE application package includes all methods and software tools required for functional and dynamic contrast enhanced kinematic imaging. Spin echo based echo planar imaging Gradient echo based echo planar imaging Functional image analysis tool and image sequence analysis tool Spectroscopy The SPECTROSCOPY application package includes all methods and software tool required for spatially resolved spectroscopy. Echo planar spectroscopic imaging Localized single voxel spectroscopy High-resolution NMR pulse sequence library Spectral processing and analysis software Relaxation The RELAXATION application package includes all methods and software tool required for evaluation of relaxation times such as T 1, T 2 and T 2 *. Multi gradient echo imaging Variable repetition time fast spin echo T 1 echo planar imaging T 2 echo planar imaging T 2* echo planar imaging Short-TE Imaging The SHORT-TE application package includes all methods and software tool required for imaging samples with short echo times. Fast spin-echo imaging with very short echo times Spiral imaging Ultra short echo time imaging Zero echo time 3D imaging

8 Pioneering Preclinical Imaging Solutions Bruker is a leading provider of high-performance scientific instruments for preclinical and industrial analysis and research with more than 5 decades experience in these fields. Today we are global market leader in MRI. This enables us to provide our customers a wide range of advanced, pioneering preclinical imaging solutions and unmatched number of modalities. Bruker BioSpin T /13 Bruker BioSpin info@bruker-biospin.com