Sensing Opportunities for Diagnostics in Healthcare and Wellbeing

Transcription

1 Sensing Opportunities for Diagnostics in Healthcare and Wellbeing Micronova Workshop summary and next steps

2 Sensing Opportunities for Diagnostics in Healthcare and Wellbeing Societal needs Grand challenges Value chain building - Bridging the innovation gap Bring all different players together Identify and select common topics for collaboration Goal oriented approach => Actions and Next steps how to continue to crate innovations for Healthcare and wellbeing Start of the Health Factory ecosystem

3 Sensing Opportunities for Diagnostics in Healthcare and Wellbeing

4 Workshop Groups 1. Mobile diagnostics, rehabilitation and sport: Jouni Lounasmaa, COO, Traxmeet Oy 2. Ageing and memory disorders, independent living: Raimo Sepponen, Professor, Aalto University 3. Low cost diagnostics for rural areas: Harri Siitari, Senior Principal Scientist, VTT 4. Personal healthcare (metabolic syndrome, diabetes): Pekka Ihalmo, Project Manager, Culminatum 5. Neurotechnology, diagnostics and brain imagining: Risto Ilmoniemi, Academy Professor, Aalto University 6. Clinical Diagnostics: Jouko Haapalahti, Programme Director, Salwe Ltd 7. Business Models: Pekka Mustonen, Managing Director, Duodecim Medical Publications Ltd

5 Group 1. Mobile diagnostics, rehabilitation and sport Jouni Lounasmaa, COO, Traxmeet Oy

6 Participants: Mobile diagnostics, rehabilitation and sport Veli-Matti Airaksinen Aalto University Director Korhonen Timo Aalto University Professor Ilkka Tittonen Aalto University Professor Lasse Leppäkorpi Beddit.com Oy CEO Kati Takaluoma Culminatum Innovation Oy Ltd Project manager Atte Lötjönen Dublin City University Research Officer Tapani Salmi Helsinki University Hospital MD Tapani Koivukangas Lewel Group Finland Oy Specialist, Medical Devices Heikki Kuisma Murata Electronics Oy Director Advanced Development Jarkko Antila VTT Team leader Panu Helistö VTT Dr Markku Jenu VTT Key Account Manager Paula Järivinen VTT Senior scientist Eero Punkka VTT Tech. Mgr Anna Rissanen VTT Team Leader Tuija Teerinen VTT Senior Scientist Timo Varpula VTT Technology Manager Ville Viikari VTT Senior Scientist

7 Health2.0 market MARKET DRIVERS Mobility (explosion of APPs) Device divergence (dedicated devices) Service convergence (cloud) Behavioural change digital rituals Sources: The future of connected health devices, IBM Digital transformation in the Health and Wellness domain, Fjord, Oct 2012

8 Mobile diagnostics, rehabilitation and sport, Group work summary Discussion topics Data safety of personal health data Data aggregation of personal health data e.g. Taltioni Behavioural change is a big challenge: there are different personal drivers and motivation for peopl are young or old, healthy or sick, etc, depending on their life-phase and health conditions, and is al much related to use context Possible areas of interest Non-invasive analysis with e.g. (optical) MEMS sensors Long-term continuous data of personal health as a result of self-monitoring Hidden data about personal health e.g. non diagnosed diseases Wearable devices Application areas home care services with analytics task related performance measurements e.g. during work in a mine or physically demanding task, health risk analysis with sensors

9 Group 2. Ageing and memory disorders, independent living Raimo Sepponen, Professor, Aalto University

10 Participants: Ageing and memory disorders, independent living Harri Lähdesmäki Aalto University Academy Research Fellow Henna Jalovaara Culminatum Innovation Oy Ltd Project coordinator Veli Pekka Tanninen Orion Oyj Orion Pharma Senior Adviser Matti Huotari University of OULU Postdoctoral Researcher Panu Pekko VTT Senior Scientist Pekka Pursula VTT Senior Scientist Klas Hjort VTT Visiting professor

11 2. Ageing and memory disorders, independent living: Raimo Sepponen, Professor, Aalto University

12 2. Ageing and memory disorders, independent living: Raimo Sepponen, Professor, Aalto University

13 Group 3. Low cost diagnostics for rural areas Harri Siitari, Senior Principal Scientist, VTT

14 Participants: Low cost diagnostics for rural areas Sauli Törmälä BioNavis Oy CEO Holthöfer Harry Dublin University Professor Kari Jussila Master Disc Oy Co-founder Mikko Sairanen PerkinElmer Project manager Coulton Legge Reckitt Benckiser Manager Auli Pere Tekes Chief Technology Adviser Darshan Kumar University of Helsinki Mr Martin Albers VTT Dr Henri Arola VTT Research Scientist Belachew Feyssa VTT Reserach scientist Liisa Hattara VTT Research engineer Heini Saloniemi VTT Team Leader Harri Siitari VTT Senior Principal Scientist

15 Low cost diagnostics for rural areas/india - VTT Technologies for Health, Innovation program Harri Siitari, Ph.D, Docent, Senior Chief Scientist VTT Espoo, Auli Pere, Ph.D. Chief Adviser Tekes

16 Central laboratories Affordable diagnostics in rural areas/india Sampling, sample materials (central labs+poct), standardization, quality of samples POCT Technology development, specially sample related topics, also new markers needed Pricing of the system/sales of consumables Rapid prototyping services (collaborations), manufacturing expertise exists More content into the test strips Markets China (big investments in HC, copy-paste), India: many markets, Public/private sectors CFD etc can be a big investment, how to access the HC officials Very different in western countries as compared to rural areas Must give additional, real value (how many tests one can afford?) Eg still birth is a common problem, but reasons are different from western countries Service lab concept: timing/logistics StrepA test 250usd in US, in pharmacy 50usd (break down of costs) Various business models: BMGF, public HC, health economics (local), sustainable development Prioritization Needs very much still present in Africa Education (people have money) people+doctor, participate with local reliable Co (note regulations), Growing middle class, early adapters R&D together, INNOVATION BOOST To understand needs, must go there

17 Anemia Diabetes Cardiovascular diseases Infectious diseases: malaria, TB, dengue Sexually Transmitted Diseases Kidney, liver and mental problems Mother and child health Dream ticket, needs in rural areas/india Mobile and light weight Multiplex Easy to use Accurate Robust Ability to keep recordings and communicate rs affordable for a single test Education, counseling, support Partnerships to overcome cultural and language barriers In-depth local understanding From Rs. 50 lakh ultrasound machine < Rs. 1 lakh Non-expert operable

18 Signal Net signal Net signal Dream ticket, Affordable diagnostics in rural areas/india Good enough quality. Sample & sampling CRP spots Real value for patient (eg re-testing) and health Care as a whole ctni spots AIC, 200 µm channels Adeno 6404-Bio 0.5 mg/ml RSV 6404-Bio 0.1 mg/ml Inf A Kd PIV Bio 0.5 mg/ml 9705-Bio 0.1 mg/ml Cutoff Kd [Hexon protein] (ng/ml) [CRP] (pg/ml) [ctni] (pg/ml) Education: Right info in Right place at Right time Right cost structure and quality, pricing Instrument/consumables Rapid results, easy-to-use CO-DEVELOP with Local partners

19 Group 4. Personal healthcare (metabolic syndrome, diabetes) Pekka Ihalmo, Project Manager, Culminatum

20 Participants: Personal healthcare (metabolic syndrome, diabetes) Miettinen Raimo Aalto University Project coordinator Joonas Paalasmaa Beddit.com Oy Chief Scientist Pekka Ihalmo Culminatum Project Manager Riikka Paasikivi Culminatum Program Director Ulf Meriheinä Murata Electronics Oy Sr. MEMS Application Specialist Päivi Heimala VTT Senior scientist Fagerström Richard VTT Technology Manager Petri Saviranta VTT Senior scientist Thea Sipiläinen-Malm VTT Senior Scientist

21 Personal healthcare devices - Focus in diabetes and metabolic syndrome

22 Prevention, prevention and prevention Incidence of diabetes, particularly type 2 diabetes, is growing rapidly Achieving tight glycaemic control is an important factor Focus in prevention identify people at high risk for the disorder encourage them to lose weight be more physically active follow a healthy eating plan

23 Future of personal healthcare devices? Healthcare will shift from the hospital and clinic to the home and communities Consumerization of medical devices Mobile phones, tablets and laptops as platform Real-time monitoring of everyday life Sensors, chips, optics Personalized genomics as a game changer DNA sequencer plugged into a computer through a USB port

24 Workshop output: Personal healthcare Non-invasive chips/sensors for personal healthcare 1. Need: Solutions exist, but they do not communicate, integration is needed (eg. HR, GPS, weight, sweating, sleeping) Next step: Beddit and Murata 1. Need: New measurables and detection systems for non-invasive detection, eg. glucose, cholesterol, lactic acid, acetone Next step: VTT / Electronics / Philippe Monnoyer 2. Need: Swalloable, disposable sensors (i-pills) to detect gastro-intestinal track Next step: VTT / Electronics / Philippe Monnoyer 3.Need: machine vision/nose of human being: eg. Detection of epileptic seizures, stress, nervousness, hypoglycaemia Next step: VTT Tampere (Jyrki Lötjönen)

25 Group 5. Neurotechnology, diagnostics and brain imagining Risto Ilmoniemi, Academy Professor, Aalto University

26 Participants: Neurotechnology, diagnostics and brain imagining Risto Ilmoniemi Aalto University Academy Professor Brain Research Unit/ Aalto University School of Anna-Maria Bique Science M.Sc., PhD Student Antti Ahonen Elekta Oy Vice President Phong Vo Finmedex Ltd. Managing Director Indrek Tammeaid Greater Helsinki Promotion Senior Business Advisor Tarmo Lipping TTY Professor Kattelus Hannu VTT / MemsFab CEO Janne Sallinen VTT Senior Scientist Antti Tullila VTT Research Scientist

27 Brain imaging developed in Helsinki MRI EEG NIRS MEG Navigated TMS Ultra-Low-Field MRI &MEG Risto Ilmoniemi Sensing Opportunities for Diagnostics in Healthcare and Wellbeing Micronova, Espoo, Nov 20, 2012

28 The whole-head MEG dewar at BECS 2011: 72 SQUIDs, later 306 SQUIDs Simultaneous MEG and MRI FP7 project MEGMRI,

29 Neurotechnology panel, results Finland is a hub for neurotechnology, has good future potential, and is excellent for clinical trials Future trends: combined measurement and treatment devices, non-pharma treatment (neurostimulation, mobile devices, games) Interesting and fruitful collaboration areas: imaging when implants in the brain, MEG, MEG-MRI, TMS, detection of hypoxia with NIRS, human performance enhancement, consumer devices, clinic in the office/home/phone, bionic control systems, post-traumatic applications, neurogames (without sensors, with mobile device s sensors or with external sensors), data handling and storage (secure cloud storage), nutritional neurotech Next steps Swiss-Finnish NeuroTech meeting on implants (HTA; J. Tuovinen) Finnish NeuroTech meetings (FiHTA & Greater Helsinki Promotion) Coordination by BECS/Aalto Univ. (Risto Ilmoniemi) Sensing Opportunities for Diagnostics in Healthcare and Wellbeing, Micronova, Espoo, Nov 20, 2012

30 Group 6. Clinical Diagnostics Jouko Haapalahti, Programme Director, Salwe Ltd

31 Participants: Clinical Diagnostics Mikko Syrjäsuo Aalto ELEC Technology Manager Marianna Khanamiryan Aalto University- School of Science Dr. Johana Kuncova-Kallio BioNavis Oy Director of Business Development Gerald Urban IMTEK-Sensors Professor Albert Manninen MIKES Researcher Craig Richmond Mittatekniikan keskus Researcher Pekka Kostiainen Murata Electronics Oy Business Development Manager Juha Laiho Photonics Finland Koordinaattori Pasi Kallio Tampere University of Technology Professor Eeva-Liisa Lakomaa Vaisala Oyj Dr. Bin Guo VTT Research Scientist Itävaara Merja VTT Principal Scientist Jani Mäntyjärvi VTT Principal Scientist Marika Nummela VTT Research Scientist Maari Mäkinen VTT Technical Research Centre of Finland Research scientist Helena Henno VTT TK4019 Research trainee

32 Clinical Diagnostics Group work #6 (17) Results Presentation Short conclusions We have opportunities to combine resources in developing new targeted point-of-use type test systems, small is nice Most interesting topics Transfer of testing from centralized to decentralized testing Systems miniatyrization, connectivity, ITC, non-invasiveness Infection testing & emergency testing, traveller`s safety Optical breath analyses, multiplexing, companion diagnostics Next steps Possible research areas Targeted point-of-use technology program Continuation meetings Solutions for infection detection, end-user aspects, regulatory Express of interest in further activities VTT, BioNavis, Mikes, Aalto Univ, Murata, TUT, SalWe, Photonics Finland Leader for next steps to be taken VTT & Photonics Finland Juha Laiho Strategic Centre for Health and Well-being (SHOK) Research Program of Intelligent Monitoring of Health and Well-being (IMO)

33 Group 7. Business Models Pekka Mustonen, Managing Director, Duodecim Medical Publications Ltd Juhani Luotola, Orion Diagnostica Oy

34 Participants: Business Models Jan Ekström Aidertech Oy Managing Director Pekka Mustonen Duodecim CEO Niina Kuusanniemi-Abbotts Greater Helsinki Promotion Senior Business Advisor Juhani Luotola Orion Corporation Orion Diagnostica Senior Technology Manager Sakari Kettunen Planmeca Oy Design Manager, Software Ossi Tiihonen Remote Analysis Ltd. Founder Jari Viik Tampere University of Technology Professor Sirpa Jylhä VTT research scientist Julia Kantorovitch VTT Senior Researcher Anu Kaukovirta-Norja VTT Vice President Philippe Monnoyer VTT Technology Manager Tarja Nevanen VTT Principal Scientist, Team Leader Jussi Tuovinen VTT VP Tuomas Toivonen VTT Expert Services Oy Lead Auditor, Medical Devices

35 Business Models Common questions for most cases: Do you have enough funding to prove your case? Do you have the channel and resources to produce? Who is certainly ready to pay? Strategic Center for Excellence in the Field of Health and Well-being (T&H SHOK) Research Program of Intelligent Monitoring of Health and Well-being (IMO) 35

36 Strategic Centre for Health and Well-being Intelligent Monitoring of Health and Well-being (IMO) Programme Strategic Centre for Health and Well-being (SHOK)

37 Business Models SalWe as forum for developing new Business Models for Diagnostics in Healthcare and Wellbeing? New SalWe programme starting 2014 under preparation More information: Saara Hassinen p Juhani Luotola p Strategic Center for Excellence in the Field of Health and Well-being (T&H SHOK) Research Program of Intelligent Monitoring of Health and Well-being (IMO) 37

38 Seminar participants Fname Lname organisation Mikko Syrjäsuo Aalto ELEC Veli-Matti Airaksinen Aalto University Risto Ilmoniemi Aalto University Paavo Kinnunen Aalto University Heidi-Maria Lehtonen Aalto University Harri Lähdesmäki Aalto University Miettinen Raimo Aalto University Raimo Sepponen Aalto University Korhonen Timo Aalto University Ilkka Tittonen Aalto University Marianna Khanamiryan Aalto University- School of Science Jan Ekström Aidertech Oy Klaus-Peter Finke-Härkönen Ajat Oy Lasse Leppäkorpi Beddit.com Oy Joonas Paalasmaa Beddit.com Oy Johana Kuncova-Kallio BioNavis Oy Sauli Törmälä BioNavis Oy Anna-Maria Bique Brain Research Unit/ Aalto University School of Science Francois Berger CEA Mari Karsikas Centre for Health and Technology Pekka Ihalmo Culminatum Riikka Paasikivi Culminatum Henna Jalovaara Culminatum Innovation Oy Ltd Kati Takaluoma Culminatum Innovation Oy Ltd Atte Lötjönen Dublin City University Holthöfer Harry Dublin University Pekka Mustonen Duodecim Antti Ahonen Elekta Oy Terhi Kajaste FiHTA ry Johan Lundin FIMM Phong Vo Finmedex Ltd. Joni Kettunen Firstbeat Risto Rossi GE Healthcare Niina Kuusanniemi-Abbotts Greater Helsinki Promotion Indrek Tammeaid Greater Helsinki Promotion Tapani Salmi Helsinki University Hospital Kristiina Aittomäki HUS Fname Lname organisation Gerald Urban IMTEK-Sensors Jaakko Raukola KeepLoop Ali Toivola KeepLoop Tapani Koivukangas Lewel Group Finland Oy Kari Jussila Master Disc Oy Tommi Pisto Medisapiens Kristian Ranta Mendor Albert Manninen MIKES Craig Richmond Mittatekniikan keskus Pekka Kostiainen Murata Electronics Oy Heikki Kuisma Murata Electronics Oy Ulf Meriheinä Murata Electronics Oy Gustaf Järnefelt Nexstim Juhani Luotola Orion Corporation Orion Diagnostica Veli Pekka Tanninen Orion Oyj Orion Pharma Annette Onodera Oy Ajat Ltd Mikko Sairanen PerkinElmer Juha Laiho Photonics Finland Sakari Kettunen Planmeca Oy Coulton Legge Reckitt Benckiser Ossi Tiihonen Remote Analysis Ltd. Saara Hassinen Salwe Jouko Haapalahti SalWe Ltd Pasi Kallio Tampere University of Technology Jari Viik Tampere University of Technology Auli Pere Tekes Jouni Lounasmaa Traxmeet Tarmo Lipping TTY Darshan Kumar University of Helsinki Tomi Rantamäki University of Helsinki Matti Huotari University of OULU Eeva-Liisa Lakomaa Vaisala Oyj Fname Lname organisation Martin Albers VTT Jarkko Antila VTT Henri Arola VTT Belachew Feyssa VTT Bin Guo VTT Kattelus Hannu VTT / MemsFab Liisa Hattara VTT Päivi Heimala VTT Panu Helistö VTT Helena Henno VTT Klas Hjort VTT Markku Jenu VTT Buchert Johanna VTT Sirpa Jylhä VTT Paula Järivinen VTT Julia Kantorovitch VTT Anu Kaukovirta-Norja VTT Jyrki Lötjönen VTT Arto Maaninen VTT Itävaara Merja VTT Philippe Monnoyer VTT Maari Mäkinen VTT Jani Mäntyjärvi VTT Tarja Nevanen VTT Marika Nummela VTT Juha Palve VTT Panu Pekko VTT Eero Punkka VTT Pekka Pursula VTT Fagerström Richard VTT Anna Rissanen VTT Janne Sallinen VTT Heini Saloniemi VTT Sampo Sammalisto VTT Petri Saviranta VTT Harri Siitari VTT Thea Sipiläinen-Malm VTT Kristiina Takkinen VTT Tuija Teerinen VTT Andrey Timofeev VTT Tuomas Toivonen VTT Antti Tullila VTT Jussi Tuovinen VTT Timo Varpula VTT Ville Viikari VTT