What s new in Trendsetting Applications?

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1 What s new in Trendsetting Applications? Leading. With MAGNETOM. Answers for life.

2 What s new in trendsetting applications? Growth with Body MRI FREEZEit 2 Quiet Suite Advanced WARP 1,3 DotGO 1 MyoMaps 1 Faster adjustments and image reconstruction 1 1 Currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. 2 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed 3 The MRI restrictions (if any) of the metal implant must be considered prior to patient undergoing MRI exam. MR imaging of patients with metallic implants brings specific risks. However, certain implants are approved by the governing regulatory bodies to be MR conditionally safe. For such implants, the previously mentioned warning may not be applicable. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

3 What s new in trendsetting applications? Growth with Body MRI FREEZEit 1 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed.

4 Growth with Body MRI Body MRI Challenging MR in speed and robustness

5 Growth with Body MRI New certainty in liver MRI. With FREEZEit 1 and LiverLab 2. 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed. 2 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

6 New certainty in liver MRI Solution FREEZEit technology and LiverLab 2 University Hospital IKRN, Mannheim, Germany FREEZEit 1 TWIST-VIBE 1 Always the right contrast in dynamic liver MRI. StarVIBE 1 Free-breathing contrastenhanced body imaging. LiverLab 2 Quantitative liver imaging, non-invasively. 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed. 2 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

7 Always the right contrast timing in dynamic liver MRI. With TWIST-VIBE 1. 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed.

8 New Certainty in Liver MRI. With TWIST-VIBE 1. 20% more findings ** documented University Hospital Grosshadern, Munich, Germany ** Michaely HJ et al, Inv Radiology Volume 48, Number 8, August 2013; This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed.

9 New certainty in liver MRI Solution StarVIBE 1 Free-breathing contrastenhanced body imaging. StarVIBE 1 uses radial trajectories that are especially unsusceptible to motion, providing exceptional image quality in T1 imaging. Conventional StarVIBE 3 Liver MRI is made accessible to a much wider spectrum of patients! FREEZEit 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed.

10 New certainty in liver MRI Solution LiverLab 1 Quantitative liver imaging, non-invasively. LiverLab 1 is designed to provide a clinical inline workflow comprised of First look Dixon, HISTO, and Multi-echo Dixon VIBE. Non-invasive quantification of liver fat and/or iron. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

11 New certainty in liver MRI Growth with Body MRI. Your benefits Expand MRI Services FREEZEit Always the right contrast timing in dynamic liver MRI. With TWIST-VIBE. 1 Free-breathing, contrast-enhanced body imaging. With StarVIBE. 1 Quantitative liver imaging, non-invasively. With Liver Lab. 2 1 This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed. 2 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

12 What s new? DotGO 1 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

13 Go for consistent results, efficiently. Solution DotGO 1 Computer MR scanner Your Desktop one central interface Your Office specific applications DotGO 1. Go for consistent results, efficiently. Your Dot Cockpit 1 one central interface Your Dot engines specific applications 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

14 Go for consistent results, efficiently. Your benefits DotGO 1 Intuitively configure all your protocols to your standard of care. With Dot Cockpit 1. Automatically apply your standards to your exams and the clinical question at hand. With Dot engines. For true flexibility, consistency, and efficiency in MRI. With DotGO 1. * University Hospital Essen, GER, Brain Dot Engine Workflow Study 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

15 What s new? Quiet Suite 1 + This product/feature may not be commercially available in countries outside the US. Future availability cannot be guaranteed.

16 Quiet Suite + Quiet Suite + Imaging is to be seen, not heard. * This product/feature is under development and may not be commercially available in all countries. Future availability cannot be guaranteed.

17 Quiet Suite The solution Quiet Suite PETRA * QuietX * 3D T1 imaging Can barely be heard over ambient background noise Inaudible when imaging with a Tx/Rx coil QuietX localizer TSE, SE and GRE for T1, T2 and DarkFluid contrasts QuietX SWI + The product is under development and not commercially available in all countries. Its future availability cannot be ensured.

18 Can you tell the difference? No compromises image quality. Your clinical workhorse. Now quiet. Conventional T2 TSE, 512 matrix, 75 dba, TA 3:47 QuietX 84% reduction*. *Reduction in sound pressure. Data on file. Results may vary.

19 QuietX Complete, quiet orthopedic examinations Conventional QuietX Conventional QuietX Conventional Quiet + 70% reduction* 82% reduction* 72% reduction* PD TSE, 85 dba, TA 2:50 PD TSE, 75 dba, TA 2:56 T2 TSE, 88 dba, TA 3:34 T2 TSE, 73 dba, TA 3:38 T1 DarkFluid, 83 dba, TA 2:44 T1 DarkFluid, 72 dba, TA 2:44 *Reduction in sound pressure. Data on file. Results may vary.

20 Quiet Suite + Your benefits Complete, quiet examinations for neuro and orthopedics. Up to 97% reduction in sound pressure*. No compromises in image quality. 1 The product is still under development and not commercially available yet. Its future availability cannot be ensured.. *Data on file. Results may vary.

21 What s new in trendsetting applications? Advanced WARP 2 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. 2 The MRI restrictions (if any) of the metal implant must be considered prior to patient undergoing MRI exam. MR imaging of patients with metallic implants brings specific risks. However, certain implants are approved by the governing regulatory bodies to be MR conditionally safe. For such implants, the previously mentioned warning may not be applicable. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

22 Advanced WARP 1 Your goal Expand your MRI Services Avoid black holes in MSK imaging. With Advanced WARP 1. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. The 4MR MRI imaging restrictions of patients (if any) of with the metallic implant implants must brings be considered specific prior risks. to patient However, undergoing certain MRI implants exam. are MR approved imaging of by patients the governing with metallic regulatory implants brings bodies to specific be MR risks. conditionally However, safe. certain For implants such are implants, approved the by previously the governing mentioned regulatory warning bodies may to be not MR be conditionally applicable. safe. Please For such contact implants, the implant the previously manufacturer mentioned warning for the may specific not be conditional applicable. information. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

23 WARP* Advanced WARP* WARP* - Imaging in the presence of metal Clear outlines in all planes with Advanced WARP 1 SEMAC Correction of in- and through-plane distortions VAT Correction of in-plane distortions High-bandwidth protocols Reduction of field distortions, signal voids, and pileup artifacts NYU Medical Center, New York, U.S. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. * The MRI restrictions (if any) of the metal implant must be considered prior to patient undergoing MRI exam. MR imaging of patients with metallic implants brings specific risks. However, certain implants are approved by the governing regulatory bodies to be MR conditionally safe. For such implants, the previously mentioned warning may not be applicable. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

24 The upcoming advanced orthopedic application Solution Advanced WARP 1 Through-plane artifact reduction with SEMAC VAT vs. SEMAC VAT vs. SEMAC Northwestern Memorial Hospital, Chicago, U.S. University of Texas Medical Branch, Galveston, U.S. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. The 4MR MRI imaging restrictions of patients (if any) of with the metallic implant implants must brings be considered specific prior risks. to patient However, undergoing certain MRI implants exam. are MR approved imaging of by patients the governing with metallic regulatory implants brings bodies to specific be MR risks. conditionally However, safe. certain For implants such are implants, approved the by previously the governing mentioned regulatory warning bodies may to be not MR be conditionally applicable. safe. Please For such contact implants, the implant the previously manufacturer mentioned warning for the may specific not be conditional applicable. information. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

25 Advanced WARP 1. Avoid black holes in MSK imaging. Your benefits Expand your MRI Services Metal artifact correction Better soft-tissue evaluation around implants Imaging of large metal structures and total joint arthroplasties 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. The MRI restrictions (if any) of the metal implant must be considered prior to patient undergoing MRI exam. MR imaging of patients with metallic implants brings specific risks. However, certain implants are approved by the governing regulatory bodies to be MR conditionally safe. For such implants, the previously mentioned warning may not be applicable. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

26 What s new in trendsetting applications? MyoMaps 1 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

27 T1, T2 and T2* mapping on the fly. In one solution. Solution MyoMaps 1 based on HeartFreeze HeartFreeze Inline Motion Correction Fully system guided Siemens unique MyoMaps 1 Inline myocardial quantification T1 Map T2 Map T2* Map National Institute of Health, Bethesda, USA Diagnostikum Berlin, Berlin, Germany. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. Royal Brompton Hospital, London, U.K.

28 MyoMaps 1 T1, T2 and T2* mapping on the fly. In one solution. Your benefits Expand your MRI Services From visual assessment to pixel based quantification of tissue characteristics. Based on Siemens unique HeartFreeze Inline Motion Correction. Guiding cardiovascular therapy, starting earlier and more efficiently. 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

29 What s new in trendsetting applications? Faster adjustments and image reconstruction 1 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

30 syngo MR E11A 1 : new image reconstruction Up to 57% faster reconstruction times* Reconstruction time for complex reconstructions is cut by more than half. Reconstruction time reduction Example CAIPIRINHA DIXON VIBE, ipat4, 320 matrix Reduction by 57%* Due to Improved ipat 2 recon Faster DIXON algorithm Higher hardware configurations 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. * Data on file

31 What s new in trendsetting applications? Growth with Body MRI FREEZEit 1 Quiet Suite Advanced WARP 1,2 DotGO 1 MyoMaps 1 Faster adjustments and image reconstruction 1 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed. 2 The MRI restrictions (if any) of the metal implant must be considered prior to patient undergoing MRI exam. MR imaging of patients with metallic implants brings specific risks. However, certain implants are approved by the governing regulatory bodies to be MR conditionally safe. For such implants, the previously mentioned warning may not be applicable. Please contact the implant manufacturer for the specific conditional information. The conditions for MR safety are the responsibility of the implant manufacturer, not of Siemens.

32 What s new with syngo.via? 1 currently under development; not for sale in the U.S. and other countries, future availability cannot be guaranteed.

33 Thank you for your attention! Answers for life.

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