Principal Subsidiaries and Affiliates (as of August 2013)
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1 Principal Subsidiaries and Affiliates (as of August 2013) Astellas is a group of companies engaged solely in the pharmaceutical business. The group consists of 82 companies, which include, 78 consolidated subsidiaries, and three affiliates accounted for by the equity method. Major group companies are listed as follows. Americas Holding company in North America Astellas US Holding, Inc. 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: Headquarters in North America Astellas US LLC 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: R&D bases Astellas Pharma Global Development, Inc. Agensys, Inc. Astellas Research Institute of America LLC Manufacturing bases Astellas Pharma Technologies, Inc. Astellas US Technologies, Inc. Sales bases Astellas Pharma US, Inc. Astellas Pharma Canada, Inc. (Canada) Astellas Farma Brasil Importação e Distribuição de Medicamentos Ltda. (Brazil) Other Astellas Venture Management LLC Astellas Scientific and Medical Affairs, Inc. Note: All subsidiaries for which no country has been indicated are located in the United States Europe Holding company in Europe Astellas B.V. Sylviusweg 62, PO Box 344, 2300 AH Leiden, The Netherlands TEL: European headquarters Astellas Pharma Europe Ltd Hillswood Drive, Chertsey, Surrey, KT16 0RS, U.K. TEL: R&D and manufacturing bases Astellas Pharma Europe B.V. (R&D and Manufacturing, Netherlands) Astellas Ireland Co., Limited (Development and Manufacturing, Ireland) Sales bases Astellas Pharma Ges. mbh (Austria) Astellas Pharma B.V. (Branch) (Belgium) Astellas Pharma s.r.o (Czech Republic) Astellas Pharma A/S (Denmark) Astellas Pharma S.A.S (France) Astellas Pharma GmbH (Germany) Astellas Pharmaceuticals AEBE (Greece) Astellas Pharma Kft. (Hungary) Astellas Pharma Co., Limited (Ireland) Astellas Pharma S.p.A. (Italy) Astellas Pharma B.V. (Netherlands) Astellas Pharma International B.V. (Export, Netherlands) Astellas Pharma Sp.zo.o. (Poland) Astellas Farma Limitada (Portugal) ZAO Astellas Pharma (Russia) Astellas Pharma d.o.o. (Slovenia) Astellas Pharma (Pty) Limited (South Africa) Astellas Pharma S.A. (Spain) Astellas Pharma A.G. (Switzerland) Astellas Pharma ilaç Ticaret ve Sanayi A.S. (Turkey) Astellas Pharma Ltd. (United Kingdom) 136 Annual Report 2013
2 Asia & Oceania Sales bases, other Astellas Pharma China, Inc. (Sales and Manufacturing, China) Astellas Pharma Hong Kong Co., Ltd. (Hong Kong) Astellas Pharma Taiwan, Inc. (Taiwan) Astellas Pharma Korea, Inc. (Korea) Astellas Pharma Philippines, Inc. (Philippines) Astellas Pharma (Thailand) Co., Ltd. (Thailand) P.T. Astellas Pharma Indonesia (Indonesia) Astellas Pharma India Private Limited (India) Astellas Pharma Australia Pty Ltd (Australia) Astellas Pharma Singapore Pte. Ltd. (Singapore) Scope of environmental information report Japan Manufacturing base Astellas Pharma Tech Co., Ltd. R&D bases Astellas Research Technologies Co., Ltd. Astellas Analytical Science Laboratories, Inc. Other Astellas Business Service Co., Ltd. Astellas Learning Institute Co., Ltd. Astellas Marketing and Sales Support Co., Ltd. Lotus Estate Co., Ltd. Company name Facility Location Function Nihonbashi Office Chuo-ku, Tokyo Headquarters Hasune Office Itabashi-ku, Tokyo Development Takahagi Chemistry & Technology Developmnent Center Takahagi, Ibaraki Tsukuba Research Center Tsukuba, Ibaraki Tsukuba Biotechnology Research Center Tsukuba, Ibaraki Yaizu Pharmaceutical Research Center Yaizu, Shizuoka Research Kiyosu Research Office Kiyosu, Aichi Kashima R&D Center Yodogawa-ku, Osaka Branches/Sales Offices 14 branches, 159 sales offices Sales & marketing Nishine Plant Hachimantai, Iwate Takahagi Technology Center Takahagi, Ibaraki Astellas Pharma Tech Co., Ltd. Yaizu Technology Center Yaizu, Shizuoka Fuji Plant Fuji, Shizuoka Toyama Technology Center Toyama, Toyama Takaoka Plant Takaoka, Toyama Manufacturing Astellas Pharma Technologies Inc. Norman Plant U.S.A. Dublin Plant Astellas Ireland Co., Limited Kerry Plant Ireland Astellas Pharma Europe B.V. Meppel Plant Netherlands Astellas Pharma China, Inc. Shenyang Plant China Note: Operating sites throughout this report are in principle identified according to the name of each facility. In instances where there are multiple facilities on the same site, the following names may be applied. Takahagi Facilities (Takahagi Chemistry & Technology Development Center and Takahagi Technology Center) Yaizu Facilities (Yaizu Pharmaceutical Research Center and Yaizu Technology Center) Annual Report In Brief Economy Employees Society Environment Compliance Corporate Governance Financial Section
3 Corporate Data/Investor Information Company Name Head Office 2-5-1, Nihonbashi-Honcho, Chuo-ku, Tokyo , Japan TEL: Capital (as of March 31, 2013) 103 billion Representative Yoshihiko Hatanaka Representative Director, President and CEO Founded 1923 Professional Institution Affiliation International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) * Masafumi Nogimori (Representative Director and Chairman) was appointed Vice President of the IFPMA in November Common Stock (as of March 31, 2013) Authorized: 2,000,000,000 Issued: 467,964,635 (including 16,788,579 treasury stock) Number of shareholders: 49,335 Stock Exchange Listing Tokyo (Ticker Code: 4503) Independent Auditors Ernst & Young ShinNihon LLC Hibiya Kokusai Building, Uchisaiwai-cho, Chiyoda-ku, Tokyo , Japan Transfer Agent for Common Stock in Japan Sumitomo Mitsui Trust Bank, Limited 1-4-1, Marunouchi, Chiyoda-ku, Tokyo , Japan * Please direct inquiries concerning Annual Report 2013 to: Corporate Communications TEL: FAX: Issued in August 2013 (Our next annual report is scheduled to be issued in August 2014) 138 Annual Report 2013
4 Major Shareholders (as of March 31, 2013) Name Breakdown of Shareholders (as of March 31, 2013) Shares owned Thousand shares (Thousand) Percentage of total common shares outstanding The Master Trust Bank of Japan, Ltd. (trust account) 25, Japan Trustee Services Bank, Ltd. (trust account) 24, State Street Bank and Trust Company 24, Nippon Life Insurance Company 14, JP Morgan Chase Bank , SSBT OD05 OMNIBUS ACCOUNT - TREATY CLIENTS 10, The Bank of Tokyo-Mitsubishi UFJ, Ltd. 9, State Street Bank and Trust Company , The Chase Manhattan Bank, NA London, SL Omnibus account 6, Mellon Bank N.A. as agent for its client Mellon Omnibus U.S. Pension 6, Notes: Shares owned are rounded down to the nearest thousand shares, while the percentage of total common shares outstanding is rounded down to two decimal places. The company holds 16,788 thousand shares of treasury stock, but it is not included in the above list of major shareholders. Treasury stock 3.6% Individuals and others 8.5% Foreign companies 49.8% Stock Prices and Trading Volumes on the Tokyo Stock Exchange (highest/lowest in the month; yen) Stock price (Yen) 6,000 5,000 4,000 3,000 2,000 Trading volumes (Thousand shares) 90,000 60,000 30,000 0 Stock price Trading volumes Nikkei stock average Japanese companies 38.2% Financial institutions 30.1% Securities companies 4.3% Other companies 3.8% Annual Report 2013 Nikkei stock average (Yen) 20,000 Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. Jan. Feb. Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. Jan. Feb. Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. Jan. Feb. Mar. Apr. May Jun ,000 12,000 8,000 4,000 In Brief Economy Employees Society Environment Compliance Corporate Governance Financial Section
5 2-5-1, Nihonbashi-Honcho, Chuo-ku, Tokyo , Japan This report is printed with environmentally friendly vegetable-based inks on FSC TM -certified paper made of wood sourced from responsibly managed forests, using a waterless printing process. Printed in Japan
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