Nubiotics PRODUCT BROCHURE. Infant Formula Range Nubiotics GOLD Nubiotics GOLD plus

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1 Nubiotics PRODUCT BROCHURE Infant Formula Range Nubiotics GOLD Nubiotics GOLD plus

2 Nubiotics THE COMPANY Nubiotics is a privately held company based in Morrinsville. We formulate and manufacture a range of nutraceutical and cosmeceutical products by harnessing the power of natural ingredients to provide products that nurture life. The healing power of many foods has been understood for centuries. In our drive to create fast acting pharmaceuticals we have largely forgotten about the healing power of natural products and food. Nutraceuticals are defined as Foods that you take on a daily basis that have a positive impact on an individuals health, physical performance or state of mind, in addition to their nutritive value (Israel Goldberg; Functional Foods; 1994). Let thy food be thy medicine and thy medicine be thy food. Hippocrates ( BC) stated Nubiotics markets a range of nutraceuticals and Cosmeceutical; Intestinal Health Product Range based on Colostrum Cosmeceutical Skin Care Range, based on Colostrum, milk lipids and active manuka honey Active Manuka Honey Range. Incl. royal jelly and pollen Healthy Start Bioactive Yogurt Range. Incl. a sheep milk yogurt range Special Nutraceutical Formulae Pregnant Mothers Formula Aged persons Formula Childs Nutritional Formula Nubiotics Infant Formula Range New Born, Follow-On and Growing Up Milk Including a unique range of bioactives found in human milk Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 2

3 Nubiotics FOUNDER & CEO Trevor Lock is the President and CEO of Nubiotics Limited. Trevor holds a Masters Degree in Biotechnology and Bio-engineering from Waikato University. He has a background in petro-chemistry but moved to the Dairy Industry approximately 25 years ago. Trevor Lock CEO Nubiotics Ltd. Trevor was Nutraceuticals Development Manager at Anchor Products Hautapu, now a Fonterra company. In this role he developed products rich in the minor bioactive, biopharmaceutical compounds found in milk. He developed processes which involved the manufacture of products such as Colostrum, Hydrolysed Proteins, Bioactive Lipids from the milk fat globule membrane, Bioactive carbohydrates and also Milk Protein Fractions. Nearly all these processes have been commercialised. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 3

4 Nubiotics EXCLUSIVE INTELLECTUAL PROPERTY A large majority of the ingredients streams Trevor has developed are now important components in Enteral Feeds, Nutraceutical Formulae, Infant Formulae, Medical foods and products that support the growth and development of the intestinal environment and also the human immune system. This depth of knowledge is now brought together in Nubiotics, a company dedicated to providing foods for people at all stages of life. Foods that when taken as part of the daily food program, provide the person with a significant health benefit. Trevor has been marketing nutraceutical foods for over 15 years in North and South America, China, SE Asia, Middle East and Russia. His knowledge is invaluable to consumers and distributors alike. While he is responsible for formulating the product range he also supports the range by travelling to the markets to train and educate consumers and marketing personal about the many benefits of his products. Nubiotics is your complete marketing partner. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 4

5 Nubiotics INFANT FORMULA RANGE Nubiotics has developed its own unique range of infant formulae for mothers who for one reason or another are unable to provide their infant with breast milk. We have incorporated key ingredients to address some of the unique components in a mothers breast milk to help the infant develop and grow. The best nutrition for babies is a mothers breast milk. It is not possible to imitate a mothers breast milk with a manufactured infant formula. The evidence is clear, that breast fed babies are more healthy and get a much better start in life than formula fed babies. We do the best we can with what component ingredients that we have. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 5

6 Nubiotics Infant Formula Range Every newborn baby is totally dependent on its mother for all its nutrition and support. A mothers milk is very complex and provides all the nutrition an infant needs during its first year of life. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 6

7 Nubiotics INFANT FORMULA RANGE World leading breakthrough bioactive ingredients. Nubiotics are one of only three companies worldwide to introduce a breakthrough ingredient containing a range of bioactive lipids which help to support the infant s immune system and protect the intestinal environment from pathogenic attack by bacteria that cause diarrhea. This is a major problem for all babies who are formula fed. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 7

8 Nubiotics INFANT FORMULA RANGE A mothers breast milk is very complex and contains many unique compounds important to an infants development. These special compounds are important for; Initial protection of the intestine from attack by harmful bacteria. Development of the complex human intestinal environment Building blocks for muscle and bone development Development of the brain and nervous system Development of eyes Development and growth of the infant Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 8

9 Nubiotics HERO INGREDIENTS Milk Phospholipids are very special lipids that make up the cell walls of mammals, also the milk fat globule membrane, in high concentration in brain tissue. Gangliosides are very special phospholipids that have special sugars attached, sialic acid, found in hi concentrations in brain tissue and also nerve tissue. Sphingomyelin is a very special phospholipid, again in high concentration in brain tissue, has anti colon cancer properties, important in skin health. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 9

10 Nubiotics HERO INGREDIENTS cont d Casein Phosphopeptide A portion of milk protein, that is high in phosphorus and carries phosphorus and also calcium to bone tissue. OPO A high concentration compound that assists with development of good bacteria in the lower intestine. Lutein A high concentration compound found in the eyes and essential for good eye health. It is also only found in human milk. Polyfructose A special sugar molecule, fiber, that helps develop good bacteria in the intestine, called a prebiotic. GOS Another special sugar molecule, fiber, that helps develop good bacteria in the intestine, called a prebiotic. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 10

11 Nubiotics HERO INGREDIENTS Gold Gold plus Contains; Contains; Lutein NO Lutein Yes Poly-Fructose NO Poly-Fructose Yes GOS NO GOS Yes DHA Yes DHA Yes ARA Yes ARA Yes OPO NO OPO Yes CPP Yes (low levels) CPP Yes GD 3 Yes (low levels) GD 3 Yes GM 3 Yes (low levels) GM 3 Yes Sphingomyelin Yes (low levels) Sphingomyelin Yes The GD 3, GM 3 comparison is shown on the next page Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 11

12 Ganglioside Levels in Human Milk 20 Ganglioside Concentration, mg/100ml Human Milk Days After Parturition GD3 GM3 Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 12

13 Ganglioside Levels in Nubiotics Formulae Compared to Human Milk Relative Concentration of Gangliosides mg/100g equivalent Months 6-12 Months Months 0 GD3 GM3 GD3 GM3 GD3 GM3 Human Milk Nubiotics Gold Nubiotics Gold+ Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 13

14 Nubiotics INFANT FORMULA RANGE Nubiotics Gold and Gold plus Infant Formulae are manufactured in state of the art factories with GMP compliance and are approved and audited by the Ministry of Primary Industries (NZFSA) of New Zealand. All product produced in these factories is authorised for export by the New Zealand Government agency responsible for Food Safety. Nubiotics Gold is a premium Gold specified infant formula while Nubiotics Gold plus is a very high level formula providing significant levels of key bioactive ingredients, to provide the infant with high quality nutrition for its development and growth. Both products are available in 900g cans. Compositions for both products are shown in the next set of pages. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 14

15 Nubiotics MASS COMPONENTS Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 15

16 Nubiotics MASS COMPONENTS Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Energy kj Protein g Whey Protein g Casein Protein g Fat g Linoleic Acid mg Linolenic Acid mg Carbohydrate g Ash g Moisture g Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 16

17 Nubiotics MINERALS Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Calcium mg Phosphorus mg Magnesium mg Potassium mg Sodium mg Chloride mg Iron mg Zinc mg Copper µg Manganese µg Iodine µg Selenium µg Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 17

18 Nubiotics VITAMINS & NUCLEOTIDES Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Vitamin A µg RE Vitamin D 3 µg Vitamin E mg Vitamin K 1 µg Vitamin B 1 µg Vitamin B 2 µg Vitamin B 6 µg Vitamin B 12 µg Vitamin C mg Biotin µg Β-Carotene µg Folic Acid µg Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 18

19 Nubiotics VITAMINS & NUCLEOTIDES Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Niacinamide µg Pantothenic Acid µg Total Nucleotides mg Cytidine 5 monophosphate mg Uridine 5 monophosphate mg Adenosine 5 monophosphate mg Inosine 5 monophosphate mg Guanosine 5 monophosphate mg Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 19

20 Nubiotics FUNCTIONAL COMPONENTS Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Choline mg L-Carnitine mg Taurine mg Inositol mg Lutein µg poly-fructose mg GOS mg DHA mg ARA mg OPO g CPP mg Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 20

21 Nubiotics FUNCTIONAL PHOSPHOLIPIDS Component Unit Stage months Stage months Stage months Gold Gold + Gold Gold + Gold Gold + Ganglioside GM 3 mg Ganglioside GD 3 mg Phosphatidyl Serine mg Phosphatidyl Choline mg Phosphatidyl Ethanolamine mg Sphingomyelin mg Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 21

22 Nubiotics INGREDIENT SPECS Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 22

23 OPO In human breast milk 50% of the dietary calories are supplied to newborns as fat. More than 98% of this fat is in the form of triglycerides. The fatty acids which make up the major part of the triglycerides are very specific in which position they occupy in the triglyceride structure. Palmitic (C-16) fatty acid makes up about 17% of the total fatty acids in human milk and is found specifically on the middle position, unlike in cows milk where it is found on either of the outside positions. OPO is a unique triglyceride component that imitates the position of palmitic acid in the middle position of the triglyceride. As a result the following benefits occur; Reduces stool hardness and related parental concern Reduced calcium soap formation More calcium is available for adsorption. Increased Calcium adsorption Larger skeletal mineral deposition Reduced excretion of saturated fatty acids, mainly palmitic acid Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 23

24 Casein Phosphopeptide (CPP) Casein Phosphopeptide, CPP, is harvested and purified after the hydrolysis (digestion) of bovine milk casein. It is a bioactive peptide shown to enhance the adsorption of minerals from food and beverage products. It therefore improves the consumers overall uptake of important minerals such as Calcium. Casein Phosphopeptide Forms a complex with soluble calcium Maintains Calcium levels in the lower intestine for longer periods of time Facilitates increased adsorption of Calcium, in particular Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 24

25 Lutein, poly-fructose, GOS Lutein Lutein is an important compound in the functioning of the eye. It is found in high concentrations in the retina. It is not manufactured in the body and must be gained from food. Lutein is an important ingredient for addition to infant formulae for improved eye health and function. poly-fructose and GOS Galcto-oligosaccharide and poly-fructose are important prebiotics. They are essential in infant formulae for the development of healthy bacteria in the lower bowel. They promote the growth of good bacteria and enhance the release of the important short chain fatty acids which are easily adsorbed in to the body and inhibit the growth of pathogenic bacteria. Both GOS and poly-fructose promote growth of essential bacteria in the bowel. An important function to aid the immune system function. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 25

26 Milk Phospholipids Bovine milk phospholipids are purified from butter milk collected during the butter making process. Milk Phospholipids are found in high concentrations in the milk fat globule membrane (MFGM). They are natural emulsifiers but have some important biological functions. They are found in high concentrations in human breast milk and are known to have a protective effect in the intestine of the infant. Important milk phospholipids are Sphingomyelin and the Gangliosides, GD 3 and GM 3. Sphingomyelin is important in the effective function of cellular walls. It contains long chain fatty acids and when broken down by enzymes in the epithelia (lining of the intestine) it is converted to ceramide (a special lipid made from Sphingomyelin) which acts as a lubricant and a water barrier to stop loss of water. GD3 is very high in early milk while GM3 levels do not become significant until about 35 days after birth of the baby. GD3 and GM3 deliver important sialic acid (a very special sugar which found in high concentration in brain and nerve tissue, important in the function of these organs) to the body for the development of brain and nerve tissue. Both Gangliosides are found in very high concentration in the brain. The Gangliosides GD3 and GM3 are important in the development of the intestinal microflora. They are responsible for the removal of pathogens such as E. coli from the intestine reducing the incidence of diarrhoea. A mothers body is programmed to produce different levels of these important gangliosides. The graph on the following slide indicates the changes of these compounds in a mothers breast milk. While we cannot imitate a mothers breast milk, we can now add a lot of the components found in human breast milk to help improve the efficacy of infant formulae for those mothers who are unable to breast feed Nubiotics their Limited, babies Harnessing Nature to Nurture Life 26

27 Glosssary Bioactive peptide, peptides are part of proteins and some have a role in the biochemical pathways in the body hence bioactive peptides Bovine milk casein, the two main classes of protein in milk are casein (the white proteins) and whey Calcium soap, the triglyceride is separated from the glycerol and combines with Calcium to form soap and is no longer available for nutrition. Epithelia. Lining of the intestine MFGM the membrane that surrounds the fat globule in the milk, contains high levels of phospholipids Palmitic (C16), one of the many fatty acids that bind to glycerol to make up fatty acids, in OPO it binds in the middle position of the 3 fatty acids Pathogenic bacteria- bacteria that are bad for the body and cause sickness and disease, and can kill, particularly babies and old people; examples are Salmonella, E coli, listeria Prebiotics compounds, ingredients that promote the growth of good bacteria in the intestine Sialic acid (a very special sugar which found in high concentration in brain and nerve tissue, important in the function of these organs Skeletal mineral deposition, more deposit of calcium to form strong bones Triglycerides, the individual fat molecules that make up fat, comprised of glycerol and 3 fatty acid molecules. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 27

28 Nubiotics DISTRIBUTION OFFER Nubiotics is looking to partner with a successful marketer with good distribution networks in Mainland China and SE Asia for its branded range of Infant Formulae. This range is unique and has not been seen in the marketplace before. The blend of bioactive ingredients creates a new marketing platform that others will find hard to follow. This in turn provides the partner selected with a prime position in the market. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 28

29 Nubiotics DISTRIBUTION OFFER To the right partner Nubiotics offers; Semi-exclusive right to market the product within a defined geographical region which will be based on achieving agreed performance criteria Assist with registration in country and provide all necessary materials including meeting with government officials if required Based on performance Nubiotics will look to upgrade the relationship to exclusive within defined geographic regions which may move to a partnership basis Nubiotics will establish a marketing office in the geographical area to support the distributor with their activities, with a free phone number for product enquiries Nubiotics will in conjunction with the partner establish a trust fund to be used for furthering the educational benefits of customers and other needy individuals Nubiotics will provide market seminars up to 3 times per year for the marketing partner in country to provide product training and support After a set period of time and should goals be achieved Nubiotics will provide a product discount to support in-market promotion Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 29

30 Nubiotics DISTRIBUTION OFFER Nubiotics requires; An outline of the proposed partners network and capabilities An agreed outline of the process to follow for the first 12 months of the partnership An order for a minimum of 15,000 units of each age group, this could be split as 10,000 Gold and 5,000 Gold plus, confirmed with agreed deposit A confirmed second order for 45,000 units of each age group to be split by Gold and Gold plus, to be placed as soon as the first order is shipped. Nubiotics Limited, 2013 Harnessing Nature to Nurture Life 30