Integrated Photonic Field-Effect technology for bio-sensing functional components (PHOTO-FET)

Transcription

1 Integrated Photonic Field-Effect technology for bio-sensing functional components (PHOTO-FET) Michele Muccini, coordinator CNR, Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), Bologna, Italy STREP Project Commencement date: Duration: 36 months

2 Content PHOTO-FET Consortium Photonic FET platform for Point of Care diagnostics PHOTO-FET objective Major technological challenges Exploitation potential Benefit from cooperation

3 Who are we? Partner Organisation Country Business activity area RTD role in project CO 1 CNR- Istituto per lo Studio dei Materiali Nanostrutturati, Bologna (CNR-ISMN) P 2 Imperial College London (ICL) P 3 Politecnico di Milano(IT) P 4 The Swiss Center for Electronics and Microtechnology, Inc., (CH) P 5 Molecular Vision ltd P 6 Saes Getters S.p.A. IT UK IT CH UK IT Gov. Res. Org. Research on advanced optoelectronic and photonic devices University Res. Cent. R&D in Experimental Solid State Physics University Res. Cent, R&D in Ultrafast photonics Private R&D centre specializing in microtechnology, nanotechnology, microelectronics, systems engineering. SME Lab-on-a-chip technology, Low-cost diagnostic devices Industrial Res. Lab, Res & Innovation Dept. Material science Coordination, LE-FET Technology, Laser Scanning Confocal microscopy and spectroscopy, optoelectronic characterisation of materials and heterojunctions, imaging of organic thin films and interfaces. LS-FET Technology, integration of passive optical components onto microfluidic chips. Photonic characterisation of materials and devices. Ultrafast spectroscopy. Microfluidic technology, integration of Photonic FET devices onto microfluidic chips, modelling and design of photonic microfluidic chips. Specifications for cardiovascular monitoring applications, implementation of assays into microfluidic structures, circuit design, technology assessment. Thin Film encapsulation and packaging technologies, liquid scavengers development, getters integration in PHOTO-FET devices, packaging of photonic bio-sensing components, technology assessment, exploitation.

4 Point-of-Care (PoC) diagnostics: search for disposable, fast, cheap, quantitative and precise devices photodetector glass glass light light Schematic of a Polymer Detection System developed at Molecular Vision OLED A microfluidic chip for testing of renal health: incorporating a microfluidic chip, organic LEDs and photodetectors Courtesy of Molecular Vision Ltd Major Pro: avoids bulky optical light-sources and detectors

5 Building a Photonic field-effect platform OLET concept 2D switching device enabling nanoscale integrated light-sources ~ 100 µm Charge accumulation region ~ 5 nm M. Muccini, A bright future for field-effect transitors, Nature Mat., 2006, 5, 605 Capelli, Toffanin, Muccini et al., Nature Materials,, 9, 496 OLED concept Vertical working geometry enabling large area light emission Catode Hole transpot layer Emitting layer El. transport layer Anode ~ 100 nm emission

6 PHOTO-FET approach to PoC diagnostics Light-Emitting and Light-Sensing FET integration on chip

7 PHOTO-FET Objective To develop a miniaturized cheap and disposable photonic device for bio sensing with unprecedented sensitivity and superior reliability at a markedly reduced cost.

8 Principle benefits PHOTO-FET Approach Pre-fabrication on the substrate: optimal registration between photonic devices and fluidic chip Simplified photonic device fabrication processing: potentially single layer devices can be used Improved optical coupling and guiding: significant performance gains can be expected Straightforward integration of auxiliary transistors: improved electrical driving and signal amplification at the point-of-generation

9 Major technological challanges To realize microfluidic devices with integrated passive optical component for multiple cardiac markers To realize high performance OLET devices compatible for integration onto microfluidic chips. Nature Materials,, 9, 496 To realize high performance LS-FET devices compatible for integration onto microfluidic chips. To monolithically integrate and package photonic bio-sensing components based on OLETs, LS-FETs and optical microfluidic chips.

10 Exploitation potential Patterned liquid getter technology and innovative packaging solutions Methods and architectures for monolithic integration of components on chips Commericiaize troponin/myoglobin/pro-bnp PoC diagnostic devices Light-Emitting Transistor technology for planar micron-size light sources and display technology Light-sensing FET technology

11 Benefit from cooperation Principle synergies aimed at decreasing development time and broaden exploitation opportunities advanced materials development (dielectrics, organic semiconductors, emitters) advanced manufacturing of components and integrated chips use of PHOTO-FET technology platform for complementary applications (security, display technology, metrology, etc..)