CV NAME: Luis M. Escudero. DATE AND PLACE OF BIRTH: Sevilla (Spain), October, 25 th, 1975

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1 CV NAME: Luis M. Escudero DATE AND PLACE OF BIRTH: Sevilla (Spain), October, 25 th, 1975 ADDRESS: Edificio IBiS, Lab 109. H.U. Virgen del Rocío. Avda. Manuel Siurot s/n Sevilla. SPAIN PHONE: EDUCATION April 2004, Ph.D. in Sciences (Biology) Cum Laude. Ph. D Advisor: Prof. Juan Modolell. PhD obtained at Univ. Autónoma de Madrid, Madrid (Spain) , B.S. in Biology. Faculty of Biology. University of Seville. EMPLOYMENT HISTORY January 2014 present. Ramón y Cajal Investigator. Departamento de Biología Celular. Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain. January 2011 December Miguel Servet Investigator. Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain. January 2010 January Posdoctoral research in the laboratory of Alberto Pascual. Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain. October 2004 January Postdoctoral research in the laboratory of Matthew Freeman, MRC-Laboratory of Molecular Biology, Cambridge, United Kingdom. September 1998 September PhD Student in the laboratory of Juan Modolell, CBMSO (Molecular Biology Centre Severo Ochoa), Universidad Autónoma de Madrid/CSIC, Madrid, Spain. June 1996-August Undergraduate student in the laboratory of Agustin Vioque, Universidad De Sevilla/CSIC, Seville, Spain FELLOWSHIPS AND MERITS 2013 Named member European Neuroscience Institute-NET Young investigator Named member of the Management Committee for the COST action BM1304: Applications of MR imaging and spectroscopy techniques in neuromuscular disease: collaboration on outcome measures and pattern recognition for diagnostics and therapy development Awarded with a Ramón y Cajal contract 2010 Awarded with a Spanish Ministry of Health, Miguel Servet contract 2005 Awarded with an EMBO Postdoctoral fellowship 2005 Awarded with a Postdoctoral Marie Curie Fellowship Awarded with a Predoctoral Comunidad Autónoma de Madrid Fellowship 1997 Awarded with a Spanish Ministry of Science undergraduate fellowship

2 RESEARCH SUPPORT Grant: PI13/ Project title: "Clinical and pre-clinical investigation of neuromuscular diseases through computerized image analysis. Awarding Body: Carlos III Health Institute. Length: Amount: Euro Grant: PI Awarding Body: Andalucian Health Council Project title: Technological development of a method for neuromuscular diseases diagnostic. Length: Amount: Euro Grant: RYC Awarding Body: Spanish Economy Ministry. Ramón y Cajal Program. Project title: Start up - Complex Organization of Living Matter Length: Amount: Euro Awarding Body: EUROPEAN COST OFFICE Project grant COST Action: BM1304: Applications of MR imaging and spectroscopy techniques in neuromuscular disease" Length: Amount: Networking and traveling expenses Grant: BFU Project title: Drosophila genetics and computerized image analysis for the study of neurological diseases. Awarding Body: Spanish Ministry of Science and Innovation. Length: Amount: Euro Grant: CP10/ Project title: Search and selection of Parkinson's disease candidate genes and validation by human genetic analysis. Awarding Body: Founded by the Carlos III Health Institute. Length: Amount: Euro

3 PEER-REVIEWED PUBLICATIONS - Sánchez-Gutiérrez, D., Melda Tozluoglu, Joseph D. Barry, Alberto Pascual, Yanlan Mao, Luis M. Escudero. (under review). Fundamental physical cellular constraints drive self-organization of tissues. Science. - Emmanuele, V., Kubota, A., Garcia-Diaz, B., Garone, C., Akman, H.O., Sánchez- Gutiérrez, D., Escudero, L.M., Kariya, S., Tanji, K., Quinzii, C.M., Hirano. M., (under review). Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Human Molecular Genetics. - Tadeo, I., Berbegall, A.P., Escudero, L.M., Álvaro, T., Noguera, N. (2014). Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance and implications in oncology and mechanotherapy. Frontiers in Oncology. 4:39. - Álvarez-Quilón, A., Serrano-Benítez, A., Lieberman, J. A., Quintero, C., Sánchez- Gutiérrez, D., Escudero, L.M., Cortés-Ledesma, F. (2014). ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nature Communications. 5: Sánchez-Gutiérrez, D., Sáez, A., Pascual, A., Escudero, L.M. (2013). Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution. PLoS ONE 8(11). - Csikász-Nagy, A., Escudero, L.M., Guillaud, M., Sedwards, S., Baum, B., Cavaliere, M. (2013). Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis. Seminars in Cancer Biology. 23:4, Sáez, A., Acha, B., Montero-Sánchez, A., Rivas, E., Acha, B., Escudero, L.M. #, Serrano, C. # (2013). A neuromuscular disease classification system. Journal of Biomedical Optics. 18(6): ( # Corresponding authors). - Sáez, A., Rivas, E., Montero-Sánchez, A., Paradas, C., Acha, B., Pascual, A., Serrano, C., Escudero, L.M. (2013). Quantifiable diagnosis of muscular dystrophies and neurogenic atrophies through network analysis. BMC Medicine 11:77. - Aldaz, S*., Escudero, L.M.*, Freeman, M. (2013). Dual role of myosin II during Drosophila imaginal disc metamorphosis. Nature Communications 4, (* These authors contributed equally to this work). - Gao, L., Hidalgo-Figueroa, M., Escudero, L.M., Díaz-Martín, J., Lopez-Barneo, J., and Pascual, A. (2013). Age-mediated transcriptomal changes in adult mouse substantia nigra. Plos One 8 (4). - Escudero, L.M. #, Costa, L. da F., Kicheva, A., Briscoe, J., Freeman, M. and Babu, M. M. # (2011). Epithelial organisation revealed by a network of cellular contacts. Nature Communications 2, 526. ( # Corresponding authors). - Aldaz, S*., Escudero, L.M.*, Freeman, M. (2010). Live imaging of Drosophila imaginal disc development. PNAS 107(32), pp (* These authors contributed equally to this work).

4 - Aldaz, S., Escudero, L.M. (2010). Imaginal Discs. Current Biology 20 (6), pp R429-R Escudero, L.M., Bischoff, M., Freeman, M. (2007). Myosin II Regulates Complex Cellular Arrangement and Epithelial Architecture in Drosophila. Developmental Cell 13 (5), pp Escudero, L.M., Freeman, M. (2007). Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Developmental Biology 7, art. no Wei, S.-Y., Escudero, L.M., Yu, F., Chang, L.H., Chen, L.-Y., Ho, Y.-H., Lin, C.-M., Chou, C.-S., Chia, W., Modolell, J., Hsu, J.-C. (2005). Echinoid is a component of adherens junctions that cooperates with DE-cadherin to mediate cell adhesion. Developmental Cell 8 (4), pp Escudero, L.M., Caminero, E., Schulze, K.L., Bellen, H.J., Modolell, J. (2005). Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development 132 (6), pp Escudero, L.M.*, Wei, S.-Y.*, Chiu, W.-H., Modolell, J., Hsu, J.-C. (2003). Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development 130, (* These authors contributed equally to this work). PATENTS Authors: LM Escudero, A Montero-Sánchez, C Paradas, E Rivas, A Pascual, A Sáez, C Serrano, B Acha Title: Método para obtener información útil para el diagnóstico de enfermedades neuromusculares Number: P Country: Spain Date: Entity: SERVICIO ANDALUZ DE SALUD REVIEWER FOR: Journal: Development Journal: Developmental Biology Journal: Plos One Journal: Journal of Complex Networks Journal: Journal of Theoretical Biology Fundação para a Ciência e a Tecnologia of Portugal. INVITED FOR TALKS: Centro de Biología Molecular Severo Ochoa. Madrid (February, 2007). Centro Andaluz Biología del Desarrollo. Seville (September, 2007). Cambridge Fly-talks series. Cambridge (February, 2008). ICREA and Institute for Research in Biomedicine (IRB). Barcelona (May, 2008). Cambridge Developmental Biology Seminar. Cambridge (November, 2008). Instituto Cajal. Madrid (Junio, 2010).

5 Instituto de Neurociencia. Alicante (December, 2011). Centro Andaluz Biología del Desarrollo. Seville (March, 2012). CABIMER. Seville (May, 2012). Spanish Society of Neurology. Barcelona (December, 2012). Computational Biology Junior Principal Investigator Meeting. Berlin (July, 2013). EuBIAS Barcelona (October, 2013). 23 rd European Drosophila Research Conference. Barcelona (October, 2013). Dunn School of Pathology. Oxford University. Oxford (May, 2014). MRC-Laboratory for Molecular Cell Biology. UCL. London (May, 2014).