In Vitro Fertilization and Embryo Transfer

Transcription

1 The Office of Continuing Medical Education, 28th Annual In Vitro Fertilization and Embryo Transfer A Comprehensive Update 2015 Sunday Wednesday July 19-22, 2015 Four Seasons Biltmore Santa Barbara, California

2 28th Annual In Vitro Fertilization and Embryo Transfer A Comprehensive Update 2015 The Office of Continuing Medical Education, CONFERENCE THEME: Vitrification and Deferred Embryo Transfer Are Revolutionizing the Effectiveness and Safety of IVF July 19-22, 2015 This program brings together a renowned faculty to present the latest developments in every phase of in vitro fertilization and embryo management. The course addresses the needs of practicing scientists, gynecologists, reproductive endocrinologists, residents, and fellows who wish to review the specialty and update their knowledge in this rapidly changing and expanding field. The intimate setting of the conference promotes extensive contact among speakers and participants with question periods, panels, and many opportunities for informal interaction. A very extensive course syllabus developed by the course instructors will be provided and an audience response system will be used to promote interaction with the speakers. Particular attention will be devoted this year to the rapidly expanding trend toward deferred embryo transfer, new testing for endometrial receptivity, oocyte and embryo cryopreservation, time lapse imaging of early embryo development, the impact of obesity and the maternal environment on IVF success and perinatal morbidity, practical aspects of ultrasound-guided transfer technique, and next generation techniques for PGS. A laboratory mini-symposium directed by Dr. William B. Schoolcraft will cover time lapse imaging, new methods of embryo culture, oocyte and embryo vitrification, novel sperm selection techniques, and comprehensive chromosome screening. Program Objectives To become familiar with standard, successful methods of each aspect of the clinical practice of assisted reproductive technology and in particular the very significant advantages of deferred embryo transfer, made possible through vitrification; alternatives to full stimulation; prevention of OHSS; the role of lifestyle issues in the male and female; time-lapse monitoring; aging of the follicle and oocyte; ovarian tissue and oocyte cryopreservation; newer techniques for Comprehensive Chromosome Screening; optimal hormone replacement for embryo transfer; and critical aspects of embryo transfer technique. To learn aspects of embryo culture and embryo management to achieve optimal results with IVF. To learn about novel methods for sperm selection, non-invasive methods for embryo selection, and options for fertility preservation for the woman with cancer. Cover: From Atlas of the Human Oocyte and Early Conceptus, Lucinda L. Veeck, MLT, ASCP Reprinted with permission from Williams & Wilkins, Baltimore. January 6, 1988.

3 COURSE CHAIR Barbara E. Mathews, MD Gynecologist in private practice, Santa Barbara, California COURSE DIRECTOR David R. Meldrum, MD Scientific Director, Reproductive Partners La Jolla, California; Clinical Professor, Department of Obstetrics and Gynecology, UC San Diego and COURSE CO-DIRECTOR William B. Schoolcraft, MD Medical Director, Colorado Center for Reproductive Medicine, Lone Tree, Colorado and Scientific Co-director, Reproductive Partners La Jolla, California GUEST FACULTY Douglas T. Carrell, PhD, HCLD Professor of Surgery (Urology), Physiology and Obstetrics and Gynecology; Director of Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, Utah Robert Casper, MD Professor, Division of Reproductive Sciences, University of Toronto; Camille Dan Family Research Chair in Translational Cell Biology and Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada Marcelle I. Cedars, MD Professor and Vice Chair, Department of Obstetrics, Gynecology and Reproductive Endocrinology and Infertility, University of California, San Francisco Ana Cobo, PhD Director, Ovodonation and Cryobiology Unit, IVF Laboratory, IVI Valencia, Valencia, Spain Susan L. Crockin, JD Principal, Crockin Law & Policy Group, PLLC; Scholar, The O Neill Institute for National and Global Health Law, Georgetown U. Law Center; Faculty Affiliate in Residence, Kennedy Institute of Ethics, Georgetown University, Washington, DC Dominique de Ziegler, MD Professor and Head, Reproductive Endocrinology, Hopital Cochin, Paris, France Antoni J. Duleba, MD Professor and Chief, Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California at San Diego Daniel A. Dumesic, MD Division Chief, Reproductive Endocrinology and Infertility, Professor, Department of Obstetrics and Gynecology, David Geffen School of Medicine, Los Angeles, California Daniela Galliano, MD, PhD Physician, IVI Barcelona; Scientific Researcher, IVI Foundation, Barcelona, Spain Joseph C. Gambone, DO, MPH Professor Emeritus of Obstetrics and Gynecology, David Geffen School of Medicine, Los Angeles, California Gabriel Garzo, MD Associate Clinical Professor, University of California, San Diego; Medical Director, Reproductive Partners La Jolla, California Aaron J. W. Hsueh, PhD Professor, Division of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California Mandy Katz-Jaffe, PhD Research Director, Colorado Center for Reproductive Medicine, Lone Tree Colorado Kirstine Kirkegaard, MD, PhD Post Doc, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark Isaac Kligman, MD Associate Professor of Obstetrics and Gynecology; Associate Professor of Reproductive Medicine; Ronald O. Perelman and Claudia Cohen Center of Reproductive Medicine, Weill Cornell Medical College, New York, New York Craig Niederberger MD, FACS Clarence C. Saelhof Professor and Head, Department of Urology, UIC College of Medicine. Professor, Department of Bioengineering, UIC College of Engineering, Chicago, Illinois Antonio Pellicer, MD Professor of Obstetrics and Gynecology and Director, Instituto Valenciano de Infertilidad (IVI), University of Valencia, Spain Thomas B. Pool, PhD Laboratory Director, Fertility Center of San Antonio, San Antonio, Texas Richard T. Scott, Jr., MD, HCLD Professor and Director, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology and Reproductive Science, Robert Wood Johnson Medical School - UMDNJ; Scientific Director, Reproductive Medicine Associates of New Jersey, Morristown, New Jersey Carlos Simon, PhD Professor of Obstetrics and Gynecology, Valencia University, Spain; Adjunct clinical Professor, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California; Scientific Director of Instituto Valenciano de Infertilidad (IVI) and IVIOMICS Gary D. Smith, PhD, HCLD Professor, Departments of OB/GYN, Physiology, and Urology; Director, MStem Cell Laboratories; Co-Director, Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan Jason E. Swain, PhD, HCLD Scientific Director, ART Laboratories, Center for Reproductive Medicine, University of Michigan, Ann Arbor, Michigan Bill Yee, MD President and Medical Director, Reproductive Partners Medical Group, Westminster, California; Associate Adjunct Professor, Department of Obstetrics and Gynecology, University of California, Irvine

4 Program 28th Annual In Vitro Fertilization and Embryo Transfer Sunday, July 19 Afternoon Registration/Exhibits 1:00 Introduction Barbara E. Mathews, MD Focus Session GnRH Agonists and Antagonists 1:10 Adjuncts to Stimulation Agonists, OC, Estrogen, LH, Low Dose Aspirin, Growth Hormone, Androderm, Letrozole, DHEA, Dexamethazone. David R. Meldrum, MD 1:35 Advantages and Disadvantages of GnRH Antagonists. Antonio Pellicer, MD 1:55 GnRH Antagonist Cycles Is There an Ideal Gonadotropin Regimen and Are There Specific Instances When Deferred Transfer Should be Recommended? Richard T. Scott, Jr., MD, HCLD 2:15 Panel/Questions and Answers Drs. Pellicer, Scott Moderator: Dr. Meldrum 2:30 Coffee Break/Exhibits Focus Session Alternatives to Full Stimulation and Fresh Transfer 3:00 Natural and Modified Natural Cycles David R.Meldrum, MD 3:15 With Vitrification and Deferred Transfer, is Clomiphene Citrate the New Natural Cycle? Bill Yee, MD 3:30 Clomiphene Citrate/Gonadotropins Antoni J. Duleba, MD 3:50 Etiology, Prevention and Treatment of Ovarian Hyperstimulation Antonio Pellicer, MD 4:20 Is Lupron Trigger and Delayed Embryo Transfer the Optimal Approach for Women With PCOS Undergoing IVF, and Will Delayed Transfer be Optimal for Other Patient Groups Having a Reduced Prognosis in Fresh Transfer Cycles? Antoni J. Duleba, MD 4:40 Panel/Questions and Answers: The Future of COH Drs. Yee, Duleba, Pellicer Moderator: Dr. Meldrum 5:00 Adjourn 6:00 Welcome Reception Monday, July 20 Morning 7:00 Continental Breakfast/Exhibits 8:00 Transvaginal Follicle Aspiration Making Difficult Retrievals Easier and Minimizing Risks David R. Meldrum, MD 8:30 Questions and Answers 8:40 Uterine Receptivity and the Importance of Embryo-Endometrial Synchrony Carlos Simon, PhD 9:10 Questions and Answers 9:20 Medical and Surgical Treatment of Endometriosis Before IVF Help or Harm? Dominique de Ziegler, MD 9:45 Questions and Answers 10:55 Fertility Preservation for the Woman with Cancer Antonio Pellicer, MD 10:20 Questions and Answers 10:30 Coffee Break/Exhibits 11:00 Medical Conditions and IVF Obesity, Thyroid, Depression, Hypertension Marcelle I. Cedars, MD 11:15 Uterine Defects and Implantation Daniela Galliano, MD, PhD 11:35 Questions and Answers 11:45 Stem Cells and Tissue Engineering in Reproductive Medicine Can We Fashion New Eggs, Sperm and Endometrium? Carlos Simon, PhD 12:10 Questions and Answers 12:20 Lunch Afternoon 1:30 Impact of Stress, Counseling, Acupuncture, Smoking, Alcohol, Caffeine, Exercise, Nutrition, Sexual Function, Supplements Critical Factors in Successful Outcomes David R. Meldrum, MD 1:50 Questions and Answers 2:00 The Key to Better Embryos is Mimicking Physiology Cumulus Co-culture, Prostacycline, Motion, Continuous Media Replenishment, Reduced Oxygen and Sperm Exposure Gary D. Smith, PhD, HCLD 2:20 Questions and Answers 2:30 Mitochondria in Cumuli, Oocytes, and Embryos and the Effects of Aging Robert Casper, MD 2:50 Questions and Answers 3:00 Coffee Break/Exhibits 3:30 Time Lapse Monitoring Choosing the Best Embryo from Timing of Early Events During Embryo Culture Kirstine Kirkegaard, MD, PhD 3:50 Questions and Answers 4:00 Vitrification of Oocytes and Embryos Has Revolutionized IVF-ET Ana Cobo, PhD 4:20 Questions and Answers

5 4:30 Hormone Replacement Cycles for Oocyte Donation and Deferred Transfer is There an Ideal Regimen? Robert Casper, MD 4:50 Questions and Answers 5:00 Adjourn Tuesday, July 21 Morning 7:00 Continental Breakfast/Exhibits 8:00 What Makes a Man Infertile and How do We Find him? Craig Niederberger, MD, FACS 8:20 Questions and Answers 8:30 The Role of the Sperm in Achieving the Best Embryos In Vitro Douglas T. Carrell, PhD, HCLD 8:50 Questions and Answers 9:00 The Difficult ICSI Cases Cryptozospermia, Immotile Sperm, and Where ICSI Has Previously Failed Isaac Kligman, MD 9:20 Questions and Answers 9:30 How to Best Get Sperm From an Obstinate Testicle? Craig Niederberger, MD, FACS 9:50 Questions and answers 10:00 Coffee Break/Exhibits 10:30 The Limits of Day 3 Biopsy for PGS- A Re-evaluation Mandy Katz-Jaffe,PhD 10:50 Questions and Answers 11:00 Comprehensive Chromosome Screening Is NextGen Likely to Be the Final Best Platform? Richard T. Scott, Jr., MD, HCLD 11:20 Questions and Answers 11:30 Non-Invasive Methods for Embryo Selection William B. Schoolcraft, MD 11:50 Questions and Answers 12:00 In Vitro Activation (IVA) of Ovarian Follicles for Infertility Treatment Aaron J.W. Hsueh, PhD 12:20 Questions and Answers 12:30 Lunch Afternoon: OPTIONAL MINI-SYMPOSIUM ON THE IVF LABORATORY: DEBATES 1:30 Novel Imaging Techniques vs. Standard Imaging for Oocytes, Sperm, and Embryos Gary D. Smith, PhD, HCLD Jason E. Swain, PhD, HCLD 2:00 Oocyte vs. Embryo Banking Mandy Katz-Jaff, PhD Ana Cobo, PhD 2:30 Novel Sperm Selection Techniques (PICSI, IMSI) vs. Standard Methods Thomas B. Pool, PhD, HCLD Douglas T. Carrell, PhD, HCLD 3:00 Time-Lapse Will it Improve Embryo Selection? Kirstine Kirkegaard, MD, PhD Thomas B. Pool, PhD, HCLD 4:00 Routine CCS For All Patients vs. Selected Application Mandy Katz-Jaffe, PhD Jason E. Swain, PhD, HCLD 4:30 Continuous, Uninterrupted Culture vs. Interrupted Culture/Media Change Thomas B. Pool, PhD, HCLD Gary D. Smith, PhD, HCLD 5:00 Panel/Questions and Answers 5:30 Adjourn Wednesday, July 22 Morning 7:00 Continental Breakfast/Exhibits 8:00 Some Adverse Outcomes are Higher with ART- Is Prevention Possible? Joseph C. Gambone, DO, MPH 8:30 Questions and Answers 8:40 The Endometrium and IVF Morhologic and Histopathologic Changes Preventing Ongoing Pregnancy Dominique de Ziegler, MD 9:10 Questions and Answers 9:20 Transfer Technique The Precision of Ultrasound-guided Transfer is Crucial for SET William B. Schoolcraft, MD 9:50 Questions and Answers 10:00 Coffee Break/Exhibits 10:30 Single Embryo Transfer - The Ultimate Goal to Optimize IVF Outcomes Gabriel Garzo, MD 10:50 Questions and Answers 11:00 The Barker Hypothesis Optimizing the Health of Our IVF Offspring May Also Involve Paying Attention to the Male Contribution. Daniel A. Dumesic, MD 11:20 Questions and Answers 11:30 Immunogical and Hematologic Evaluation Prior to IVF and For RSA When Should Thrombophilia Testing be Done? Richard T. Scott, Jr., MD, HCLD 11:50 Questions and Answers 12:00 Legal Pitfalls of ART How to Keep You and Your Patients Out of Hot Water Susan L. Crockin, JD 12:20 Questions and Answers 12:30 Adjourn FOR OTHER UCLA CME OFFERINGS: or cme@deans.medsch.ucla.edu or FAX: (310)

6 Accreditation The Office of Continuing Medical Education,, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Office of Continuing Medical Education,, designates this live activity for a maximum of 21 AMA PRA Category I credit(s). (18 credits for the general session, 3 credits for the minisymposium on the IVF laboratory). Physicians should claim only the credit commensurate with the extent of their participation in the activity. Disclosure The FDA has issued a concept paper which classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is truly independent and free of commercial influence. In addition to independence, the FDA requires that non-promotional, commercially supported education be objective, balanced, and scientifically rigorous. The policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program s participants. In addition, Accreditation Council for Continuing Medical Education policy now mandates that the provider adequately manage all identified potential conflicts of interest prior to the program. We at UCLA fully endorse the letter and spirit of this concept. Fees $1, Physicians/Laboratory Directors $1, Residents, Technicians, Nurses (accompanied by confirmatory letter of status from department chief or training director) Mini-symposium on the IFV Laboratory $ all registrants Enrollment fee includes continental breakfast 3 days; lunch, 2 days for program participants, as well as a welcome reception for program participants and their spouse/guest. The Setting Santa Barbara Founded in 1782, the city of Santa Barbara is proud of its Spanish colonial heritage. Situated amid 30 miles of spectacular, curving California coastline and partially encircled by coastal mountains, the city enjoys an ideal climate. Here lies a grand mix of art, history, culture, and entertainment for free-time activities. One may wish to stroll along the palm-lined beaches, visit Stearns Wharf (with its specialty shops, restaurants, and fishing pier), the grand Mission Santa Barbara, world-famous Spanish Courthouse, and old adobes. Santa Barbara also has many art galleries, several museums, botanical gardens, and fine antique shops. The University of California, Santa Barbara has an extensive library and distinguished institute of environmental stress. Nearby, in the Santa Ynez valley, is the quaint Danish village of Solvang, and tours of local vineyards are available. The sunny oceanside environment has an average year-round temperature of 70 degrees with little or no rainfall in late summer. Accommodations THE FOUR SEASONS BILTMORE 1260 Channel Drive Santa Barbara, CA (805) The course is being held at the exclusive Four Seasons Biltmore Hotel. A block of rooms has been reserved and will be held until June 6, 2015 for seminar participants at a special conference rate of $465 per night, single or double occupancy, plus 10.08% sales tax (subject to change). A California Tourism Assessment fee of 0.08% will also be charged to each guest bill as well as a Santa Barbara Tourism Assessment fee of $2 per room night. Confirmation of reservations received after June 6, 2015 are subject to availability. There is always the possibility our room block might sell out prior to June 6, 2015 in which case rooms will be sold at a higher rate based on availability. Please reserve early. Each program participant is limited to one guestroom at the conference rate. Conference Parking Overnight self-parking is complimentary (usually $19). If you choose to leave your car overnight with the valet, the fee is $35 per night. (The valet overnight rate is subject to change.) Four Seasons Biltmore Hotel Reservation Instructions Please Read Carefully! Once you have enrolled in the conference, you will be mailed, along with your course registration confirmation, a Four Seasons Biltmore room reservation form. Once received, this form must be FAXED directly to The Four Seasons to secure your hotel reservation. This is the only way to reserve a room at The Four Seasons. FAX this form directly to the hotel as soon as you receive it. Faxing instructions will be on the form. The sooner you enroll, the sooner you can make your hotel reservation. All reservation arrival and/or departure dates must be finalized no later than 40 days (6/6/15) prior to the UCLA In Vitro Fertilization conferences beginning on July 19, Any changes made by the participants arrival and/or departure dates, received by the hotel less than 40 days in advance will become the sole responsibility of the UCLA IVF conference participant. The hotel will attempt to resell all rooms released in an effort to mitigate UCLA conference participants potential liability. However, if a guestroom is released and remains unsold by the hotel, the UCLA conference participant will personally assume the guestroom per night charge for the unsold room. For questions regarding reservations, please call Thank you for your cooperation. THE MONTECITO INN 1295 Coast Village Road Santa Barbara, CA A small block of rooms has also been reserved at The Montecito Inn, just two blocks away from The Four Seasons Biltmore at a special conference rate of $ for a standard King Room, and $ for a Mountain View King room per night plus city and room tax. If

7 you would prefer to stay at this hotel, please call them directly and mention the UCLA IVF conference when making the reservation. Outside California call or call inside California. Ground Transportation Taxi service is available from the Santa Barbara airport to The Four Seasons Biltmore. General Information Refunds Cancellations must be received in writing by June 17, 2015, and will be subject to a $75 processing fee. No refunds will be given after June 17th. A full refund will be provided if for any reason the course must be canceled or rescheduled. For additional information, contact The Office of Continuing Medical Education,, Wilshire Blvd., Ste. 1060, Los Angeles, CA , (310) Enrollment Enrollment is limited. Early enrollment is strongly suggested. By Mail Enroll now by mail using form attached. For additional applications, use photocopy or separate sheet giving all information requested on form. By Phone For your convenience, enrollment may be charged on your MasterCard, VISA, American Express or Discover. Call (310) By FAX Send completed enrollment form with charge card information and authorizing signature. FAX Number (310) Online Go to course listings, scroll down to this conference and follow the instructions for online enrollment. Application for Enrollment (Please Print) Summer 2015 Course Title and Number Amount In Vitro Fertilization and Embryo Transfer M156-6 Optional Mini-Symposium on the IVF Laboratory M156-6A Total Last four digits of your Social Security Number u Please check if new address Name (First/Middle/Last) u Male u Female Degree Preferred Mailing Address City/State/ZIP ( ) ( ) ( ) Area Code Daytime Phone Area Code FAX Area Code Mobile Phone Specialty address Check enclosed payable to: The Regents of the University of California Charge: u MasterCard u Visa u Discover u American Express Mo/Yr Authorizing Signature Expiration Date Mail to: Office of Continuing Medical Education IVF Conference Wilshire Blvd., Suite 1060 Los Angeles, CA

8 UCLA Office of Continuing Medical Education 405 Hilgard Avenue MC 29 Los Angeles, California th Annual In Vitro Fertilization and Embryo Transfer A Comprehensive Update 2015 Sunday Wednesday July 19-22, 2015 Four Seasons Biltmore Santa Barbara, California NON-PROFIT ORG. U.S. POSTAGE PAID UCLA