Resources for Modern Methods

Size: px
Start display at page:

Download "Resources for Modern Methods"

Transcription

1 Resources for Modern Methods Experiences and Results Department for Environment and Energy Basel-City (AUE) Steffen Ruppe*, Dorrit Griesshaber*, Ingrid Langlois*, Jan Mazacek*, Matthias Ruff #, Martin Loos #, Heinz Singer # *Department for Environment and Energy Basel-City, Switzerland # Eawag: Swiss Federal Institute of Aquatic Science and Technology, Switzerland Kanton Basel-Stadt

2 Department for Environment and Energy Basel (AUE) The first out of seven Rhine monitoring stations is located near Basel, in Weil am Rhein. operated by AUE funded by the Federal Office for Environment (BAFU), Switzerland and the Ministry of the Environment, Sector Climate and Energy, Germany, Baden- Württemberg All samples from this station were analyzed by the AUE laboratory. Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 2

3 Resources for Modern Methods What do we need? LCMS-method measuring relevant targets at very low concentration ranges and detecting non-target substances How do we get there? In July 2009 a project started with the Eawag as scientific partner. 2011: approximately 300 substances were measured 2012: introduction of software EnviMass 1 (Martin Loos, Eawag) 2014: implementation of software EnviMass 2 method development took almost 4 years, primarily due to the missing software link Detection method and analysis software are critical factors for optimal use of resources. Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 3

4 Daily Analytical Strategy Using LC/MS-Orbitrap SPE (multiphase cartridges), 140 internal standards, measurements with a mass resolution of (+MS/MS-fragments) Target List (310) EnviMass Non-Target Priority Substances 50 Targets Manually integrated Semiquan. procedure Screening for relevant masses Trend detection Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 4

5 Priority Substance - obvious application periods in the spring and fall - daily measurements are important to detect violations of alarm limits and to enable estimations of chemical loads in the Rhine in this example, two days contributed 25 % of the annual Isoproturon load in 2013 Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 5

6 Priority Substance Aliskiren: originates from human usage (background level) and industrial production (peaks) dilution effects due to higher discharge can be observed Tizanidin: origin from industrial discharge was verified Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 6

7 Daily Analytical Strategy Using LC/MS-Orbitrap EnviMass Priority substances 50 Targets Target-List (310) Non-Target x calibration x semi-quantification x automated processing peak picking recalibration/alignment componentization prioritization EnviMass2 Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 7

8 Non-Target Screening: Mass (M+H + ) EnviMass2 computes a time series analysis comparing a current sample with last year s data set prioritization is based on a statistical method highlighting mass traces with increasing intensity EnviMass2 (July February 2014, including incident on ) ChemSpider search resulted in nearly 2000 suggestions for possible molecular formulas Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 8

9 Non-Target Screening: 2-Phenyl-2-(2-piperidin)acetamid The compound was identified knowing who discarded the substance and in cooperation with the company in question. 600 kg of the Ritalin reagent were discharged Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 9

10 Non-Target Screening: Mass (M-H - ) 13 C => 7 Carbon 15 N => 4 Nitrogen Mass resolution provide isotop distribution C7H2N4? mass accuracy < 2 ppm ChemSpider search resulted in only two suggestions due to the unusual elemental composition Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 10

11 Non-Target Screening: Mass (M-H - ) 13 C => 7 Carbon BW- 15 Holidays N => 4 Nitrogen taking the intensity profile and the timing of summer holidays in Switzerland and Germany into account, one potential pollution region is singled out discharging company was identified and provided the AUE laboratory with their reference standard Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 11

12 Non-Target Screening: Tetracarbonitrilpropen - nonessential by-product - not further monitored it poses a permanent pollution - concentration ranges from 0.2 µg/l to 1 µg/l - in December 2014 a load of 820 kg was estimated - Tetracarbonitrilpropen is stable Tetracarbonitrilpropen can be detected in samples from along the entire Rhine samples taken in 2013 at Maas-Luis showed nearly the same load It took 2 months from finding the unknown mass to identifying the compound. Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 12

13 Non-Target Screening: AMPS - initially, the concentration was estimated to be 150 ng/l using the internal standard Bentazon-D6 - the molecular structure was identified within one week!!! - the concentration was underestimated by 30-fold!!! Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 13

14 Non-Target Screening: AMPS - due to its polarity AMPS resides predominantly in the water phase - it cannot be completely removed by drinking water treatment detection of AMPS in drinking water It is necessary to pay special attention to polar substances! Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 14

15 15 LCMS-Rhine Alarms from AUE-BASEL in 2014 Substance Use Alarms 2014 Detection Load 2014 (kg) Paracetamol analgetic Feb 2014/ Nov 14 Semi-Quan 320 Aliskiren beta blocker Feb / March / April 14 Priority list 1400 Indometacin 2-Phenyl-2-(2- piperidin)acetamid analgetic beginning and end March 14 Semi-Quan 170 (in 2 weeks) Industrial chemical Feb - March 14 Nontarget 600 Toluol-4-sulfonic acid Industrial chemical Dez 14 Priority list 1500 Unknown_252 Sep 14 Nontarget 1300* Unknown_325 May 14 Nontarget 5000* Tizanidin Muscle relexant Jun 14 Priority list 150 Mecoprop Pesticide Jun 14 Priority list 320 Unknown_139 Jul 14 Nontarget 70* Tetracarbonitrilpropen Industrial chemical Nov 2014 (Info in Basel) Nontarget 14000* * load-estimation red marked substances = permanent pollutions Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 15

16 Rhine Monitoring in Basel 2010 FOCUS 2014 GCMS shifted LCMS Results Alarms 7 19 Load targets 15 t 90 t Load non-targets ca. 3 t (only GCMS) > 25 t Human resources + one full-time position Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 16

17 Summary new LC/MS technologies greatly enhance the analytical spectrum cooperation with scientific partners is necessary a daily target-analysis of nearly 300 relevant compounds is possible observed target-loads were multiplied by factor six daily non-target screening is important, using LC/MS and GC/MS techniques LC/MS non-target screening delivers relevant compounds with high loads personal statement: the benefit of the information gain greatly outweighs the cost of the additional human resources necessary Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 17

18 THANK YOU for your attention! Thanks also to: Anna Brunnert, Steffi Schreiber, Reto Dolf, Paul Svoboda and the entire AUE-Team Kanton Basel-Stadt Workshop IKSR, Steffen Ruppe, Folie 18

Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS

Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS Using PeakView Software with the XIC Manager to Get the Answers

More information

AT&T Global Network Client for Windows Product Support Matrix January 29, 2015

AT&T Global Network Client for Windows Product Support Matrix January 29, 2015 AT&T Global Network Client for Windows Product Support Matrix January 29, 2015 Product Support Matrix Following is the Product Support Matrix for the AT&T Global Network Client. See the AT&T Global Network

More information

Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances

Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances TripleTOF 5600 + LC/MS/MS System with MasterView Software Adrian M. Taylor AB Sciex Concord, Ontario (Canada) Overview

More information

# LCMS-35 esquire series. Application of LC/APCI Ion Trap Tandem Mass Spectrometry for the Multiresidue Analysis of Pesticides in Water

# LCMS-35 esquire series. Application of LC/APCI Ion Trap Tandem Mass Spectrometry for the Multiresidue Analysis of Pesticides in Water Application Notes # LCMS-35 esquire series Application of LC/APCI Ion Trap Tandem Mass Spectrometry for the Multiresidue Analysis of Pesticides in Water An LC-APCI-MS/MS method using an ion trap system

More information

Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants

Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants Metabolomic Profiling of Accurate Mass LC- Data to Identify Unexpected Environmental Pollutants André Schreiber 1, David Cox 1, Nadia Pace 1, Christopher Borton 2 1 AB SCIEX, Concord, ntario, Canada; 2

More information

Pesticide residue analysis: New Trends. Michal Godula, Ph.D. EU Marketing Manager Food Safety & Environmental Thermo Fisher Scientific

Pesticide residue analysis: New Trends. Michal Godula, Ph.D. EU Marketing Manager Food Safety & Environmental Thermo Fisher Scientific Pesticide residue analysis: New Trends Michal Godula, Ph.D. EU Marketing Manager Food Safety & Environmental Thermo Fisher Scientific Why pesticide analysis? Extensively used in agriculture to control

More information

COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) CHARTERED BANK ADMINISTERED INTEREST RATES - PRIME BUSINESS*

COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) CHARTERED BANK ADMINISTERED INTEREST RATES - PRIME BUSINESS* COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) 2 Fixed Rates Variable Rates FIXED RATES OF THE PAST 25 YEARS AVERAGE RESIDENTIAL MORTGAGE LENDING RATE - 5 YEAR* (Per cent) Year Jan Feb Mar Apr May Jun

More information

COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) CHARTERED BANK ADMINISTERED INTEREST RATES - PRIME BUSINESS*

COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) CHARTERED BANK ADMINISTERED INTEREST RATES - PRIME BUSINESS* COMPARISON OF FIXED & VARIABLE RATES (25 YEARS) 2 Fixed Rates Variable Rates FIXED RATES OF THE PAST 25 YEARS AVERAGE RESIDENTIAL MORTGAGE LENDING RATE - 5 YEAR* (Per cent) Year Jan Feb Mar Apr May Jun

More information

Calculation of Molar Masses. Molar Mass. Solutions. Solutions

Calculation of Molar Masses. Molar Mass. Solutions. Solutions Molar Mass Molar mass = Mass in grams of one mole of any element, numerically equal to its atomic weight Molar mass of molecules can be determined from the chemical formula and molar masses of elements

More information

CARBON THROUGH THE SEASONS

CARBON THROUGH THE SEASONS DESCRIPTION In this lesson plan, students learn about the carbon cycle and understand how concentrations of carbon dioxide (CO 2 ) in the Earth s atmosphere vary as the seasons change. Students also learn

More information

Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples

Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples Keywords Application Note ENV0212 This collaboration study was performed

More information

Element of same atomic number, but different atomic mass o Example: Hydrogen

Element of same atomic number, but different atomic mass o Example: Hydrogen Atomic mass: p + = protons; e - = electrons; n 0 = neutrons p + + n 0 = atomic mass o For carbon-12, 6p + + 6n 0 = atomic mass of 12.0 o For chlorine-35, 17p + + 18n 0 = atomic mass of 35.0 atomic mass

More information

Unit 2: Quantities in Chemistry

Unit 2: Quantities in Chemistry Mass, Moles, & Molar Mass Relative quantities of isotopes in a natural occurring element (%) E.g. Carbon has 2 isotopes C-12 and C-13. Of Carbon s two isotopes, there is 98.9% C-12 and 11.1% C-13. Find

More information

Determination of Pesticide Residues in Drinking Water Using Automated Solid-Phase Extraction and Gas Chromatography with Nitrogen Phosphorus Detection

Determination of Pesticide Residues in Drinking Water Using Automated Solid-Phase Extraction and Gas Chromatography with Nitrogen Phosphorus Detection Determination of Pesticide Residues in Drinking Water Using Automated Solid-Phase Extraction and Gas Chromatography with Nitrogen Phosphorus Detection Application Note 1097 Liu Qian, Zheng Hongguo and

More information

STANDARD OPERATING PROCEDURES

STANDARD OPERATING PROCEDURES PAGE: 1 of 33 CONTENTS 1.0 SCOPE AND APPLICATION 2.0 METHOD SUMMARY 3.0 SAMPLE PRESERVATION, CONTAINERS, HANDLING, AND STORAGE 4.0 INTERFERENCES AND POTENTIAL PROBLEMS 5.0 EQUIPMENT/APPARATUS 6.0 REAGENTS

More information

Thermo Scientific ExactFinder Software

Thermo Scientific ExactFinder Software mass spectrometry Thermo Scientific ExactFinder Software Workflow software for routine targeted and general unknown screening Unifies qualitative and quantitative high-resolution accurate mass workflows

More information

Case 2:08-cv-02463-ABC-E Document 1-4 Filed 04/15/2008 Page 1 of 138. Exhibit 8

Case 2:08-cv-02463-ABC-E Document 1-4 Filed 04/15/2008 Page 1 of 138. Exhibit 8 Case 2:08-cv-02463-ABC-E Document 1-4 Filed 04/15/2008 Page 1 of 138 Exhibit 8 Case 2:08-cv-02463-ABC-E Document 1-4 Filed 04/15/2008 Page 2 of 138 Domain Name: CELLULARVERISON.COM Updated Date: 12-dec-2007

More information

Analysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column

Analysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column Analysis of Free Bromate Ions in Tap Water using an ACQUITY UPLC BEH Amide Column Sachiki Shimizu, FUJIFILM Fine Chemicals Co., Ltd., Kanagawa, Japan Kenneth J. Fountain, Kevin Jenkins, and Yoko Tsuda,

More information

CALL VOLUME FORECASTING FOR SERVICE DESKS

CALL VOLUME FORECASTING FOR SERVICE DESKS CALL VOLUME FORECASTING FOR SERVICE DESKS Krishna Murthy Dasari Satyam Computer Services Ltd. This paper discusses the practical role of forecasting for Service Desk call volumes. Although there are many

More information

Mass Spectrometry. Overview

Mass Spectrometry. Overview Mass Spectrometry Overview Mass Spectrometry is an analytic technique that utilizes the degree of deflection of charged particles by a magnetic field to find the relative masses of molecular ions and fragments.2

More information

2014 Aamjiwnaang Air Monitoring Station Results. Ministry of the Environment and Climate Change April 19, 2016

2014 Aamjiwnaang Air Monitoring Station Results. Ministry of the Environment and Climate Change April 19, 2016 2014 Aamjiwnaang Air Monitoring Station Results Ministry of the Environment and Climate Change April 19, 2016 Outline Key Results Parameters Measured Benchmarks 2014 Report Results Mobile Monitoring Results

More information

Daniel M. Mueller, Katharina M. Rentsch Institut für Klinische Chemie, Universitätsspital Zürich, CH-8091 Zürich, Schweiz

Daniel M. Mueller, Katharina M. Rentsch Institut für Klinische Chemie, Universitätsspital Zürich, CH-8091 Zürich, Schweiz Toxichem Krimtech 211;78(Special Issue):324 Online extraction LC-MS n method for the detection of drugs in urine, serum and heparinized plasma Daniel M. Mueller, Katharina M. Rentsch Institut für Klinische

More information

List the 3 main types of subatomic particles and indicate the mass and electrical charge of each.

List the 3 main types of subatomic particles and indicate the mass and electrical charge of each. Basic Chemistry Why do we study chemistry in a biology course? All living organisms are composed of chemicals. To understand life, we must understand the structure, function, and properties of the chemicals

More information

Metabolomics Software Tools. Xiuxia Du, Paul Benton, Stephen Barnes

Metabolomics Software Tools. Xiuxia Du, Paul Benton, Stephen Barnes Metabolomics Software Tools Xiuxia Du, Paul Benton, Stephen Barnes Outline 2 Introduction Software Tools for LC-MS metabolomics Software Tools for GC-MS metabolomics Software Tools for Statistical Analysis

More information

Coordination and air quality monitoring during emergencies. Colin Powlesland Environment Agency

Coordination and air quality monitoring during emergencies. Colin Powlesland Environment Agency Coordination and air quality monitoring during emergencies Colin Powlesland Environment Agency Contents h Introduction h What do we want to achieve? h Implementation programme h Incident timeline h Proposed

More information

Reduction of Matrix Effects with the Agilent 1200 Infinity Series Online SPE Solution

Reduction of Matrix Effects with the Agilent 1200 Infinity Series Online SPE Solution Reduction of Matrix Effects with the Agilent 1200 Infinity Series Online SPE Solution Application Note Environmental Author Bettina Schuhn Agilent Technologies, Inc. Waldbronn, Germany Abstract The use

More information

Enhanced Vessel Traffic Management System Booking Slots Available and Vessels Booked per Day From 12-JAN-2016 To 30-JUN-2017

Enhanced Vessel Traffic Management System Booking Slots Available and Vessels Booked per Day From 12-JAN-2016 To 30-JUN-2017 From -JAN- To -JUN- -JAN- VIRP Page Period Period Period -JAN- 8 -JAN- 8 9 -JAN- 8 8 -JAN- -JAN- -JAN- 8-JAN- 9-JAN- -JAN- -JAN- -JAN- -JAN- -JAN- -JAN- -JAN- -JAN- 8-JAN- 9-JAN- -JAN- -JAN- -FEB- : days

More information

Finokalia Station - University of Crete (Greece) ECPL

Finokalia Station - University of Crete (Greece) ECPL Finokalia Station - University of Crete (Greece) ECPL Institution information The Environmental Chemical Processes Laboratory (ECPL) was established in 1997 by the Department of Chemistry and the Senate

More information

Climatography of the United States No. 20 1971-2000

Climatography of the United States No. 20 1971-2000 Climate Division: CA 4 NWS Call Sign: Month (1) Min (2) Month(1) Extremes Lowest (2) Temperature ( F) Lowest Month(1) Degree s (1) Base Temp 65 Heating Cooling 1 Number of s (3) Jan 59.3 41.7 5.5 79 1962

More information

The Mole Concept. The Mole. Masses of molecules

The Mole Concept. The Mole. Masses of molecules The Mole Concept Ron Robertson r2 c:\files\courses\1110-20\2010 final slides for web\mole concept.docx The Mole The mole is a unit of measurement equal to 6.022 x 10 23 things (to 4 sf) just like there

More information

Biocides main groups

Biocides main groups Analytical challenges for the analysis of biocides in aqueous and solid environmental matrices Arne Wick, Kathrin Broeder, Michael Schluesener, Thomas Ternes Federal Institute of Hydrology (BfG), Koblenz,

More information

Unity Lab Services Training Courses

Unity Lab Services Training Courses Unity Lab Services Training Courses the key to your laboratory s success 2015 North America Training Course Calendar LC-MS COURSE JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC LTQ Family Operations 26-29

More information

Deployment of networks of innovative water quality sensors for distribution network monitoring Joep van den Broeke (Ph.D.)

Deployment of networks of innovative water quality sensors for distribution network monitoring Joep van den Broeke (Ph.D.) AWWA Water Infrastructure Conference Deployment of networks of innovative water quality sensors for distribution network monitoring Joep van den Broeke (Ph.D.) 28 October 2014 Challenges for Water Utilities

More information

Climatography of the United States No. 20 1971-2000

Climatography of the United States No. 20 1971-2000 Climate Division: CA 6 NWS Call Sign: SAN Month (1) Min (2) Month(1) Extremes Lowest (2) Temperature ( F) Lowest Month(1) Degree s (1) Base Temp 65 Heating Cooling 100 Number of s (3) Jan 65.8 49.7 57.8

More information

Chemical Proportions in Compounds

Chemical Proportions in Compounds Chapter 6 Chemical Proportions in Compounds Solutions for Practice Problems Student Textbook page 201 1. Problem A sample of a compound is analyzed and found to contain 0.90 g of calcium and 1.60 g of

More information

Chemical Composition Review Mole Calculations Percent Composition. Copyright Cengage Learning. All rights reserved. 8 1

Chemical Composition Review Mole Calculations Percent Composition. Copyright Cengage Learning. All rights reserved. 8 1 Chemical Composition Review Mole Calculations Percent Composition Copyright Cengage Learning. All rights reserved. 8 1 QUESTION Suppose you work in a hardware store and a customer wants to purchase 500

More information

The Empirical Formula of a Compound

The Empirical Formula of a Compound The Empirical Formula of a Compound Lab #5 Introduction A look at the mass relationships in chemistry reveals little order or sense. The ratio of the masses of the elements in a compound, while constant,

More information

Strategies for analysis of unknown samples Non targeted screening with LC TOF Examples from the Swedish National Food Agency

Strategies for analysis of unknown samples Non targeted screening with LC TOF Examples from the Swedish National Food Agency Strategies for analysis of unknown samples Non targeted screening with LC TOF Examples from the Swedish National Food Agency Johan Rosén Chemist Science department, Chemistry Division National Food Agency,

More information

Chemical Calculations: The Mole Concept and Chemical Formulas. AW Atomic weight (mass of the atom of an element) was determined by relative weights.

Chemical Calculations: The Mole Concept and Chemical Formulas. AW Atomic weight (mass of the atom of an element) was determined by relative weights. 1 Introduction to Chemistry Atomic Weights (Definitions) Chemical Calculations: The Mole Concept and Chemical Formulas AW Atomic weight (mass of the atom of an element) was determined by relative weights.

More information

Analysis One Code Desc. Transaction Amount. Fiscal Period

Analysis One Code Desc. Transaction Amount. Fiscal Period Analysis One Code Desc Transaction Amount Fiscal Period 57.63 Oct-12 12.13 Oct-12-38.90 Oct-12-773.00 Oct-12-800.00 Oct-12-187.00 Oct-12-82.00 Oct-12-82.00 Oct-12-110.00 Oct-12-1115.25 Oct-12-71.00 Oct-12-41.00

More information

AMD Analysis & Technology AG

AMD Analysis & Technology AG AMD Analysis & Technology AG Application Note 120419 Author: Karl-Heinz Maurer APCI-MS Trace Analysis of volatile organic compounds in ambient air A) Introduction Trace analysis of volatile organic compounds

More information

State Water Resources Control Board Environmental Laboratory Accreditation Program

State Water Resources Control Board Environmental Laboratory Accreditation Program State Water Resources Control Board Environmental Laboratory Accreditation Program P.O. Box 100, Floor 24 850 Marina Bay Parkway, Build. P 500 N Central Ave, Suite 500 Sacramento, CA 95812-0100 Richmond,

More information

MassHunter for Agilent GC/MS & GC/MS/MS

MassHunter for Agilent GC/MS & GC/MS/MS MassHunter for Agilent GC/MS & GC/MS/MS Next Generation Data Analysis Software Presented by : Terry Harper GC/MS Product Specialist 1 Outline of Topics Topic 1: Introduction to MassHunter Topic 2: Data

More information

Performance and advantages of qnmr measurements

Performance and advantages of qnmr measurements Return to Web Version This is the first of a series of articles related to the launch of new organic CRMs certified by quantitative NMR under double accreditation. In this issue, we focus on CRMs intended

More information

Micropollutants in the aquatic environment: The Swiss strategy

Micropollutants in the aquatic environment: The Swiss strategy Micropollutants in the aquatic environment: The Swiss strategy Adriano Joss, Hansruedi Siegrist (eawag), Michael Schärer, Christian Abegglen (Bafu, VSA) Hilversum, 21 November 2013 Overview The Swiss strategy

More information

Formulas, Equations and Moles

Formulas, Equations and Moles Chapter 3 Formulas, Equations and Moles Interpreting Chemical Equations You can interpret a balanced chemical equation in many ways. On a microscopic level, two molecules of H 2 react with one molecule

More information

Optimizing Detection of Steroids in Wastewaters Using the Agilent 6490 Triple Quadrupole LC/MS System with ifunnel Technology

Optimizing Detection of Steroids in Wastewaters Using the Agilent 6490 Triple Quadrupole LC/MS System with ifunnel Technology Optimizing Detection of Steroids in Wastewaters Using the Agilent 649 Triple Quadrupole LC/MS System with ifunnel Technology Application Note Environmental Author Neil Cullum Anglian Water Services Huntingdon,

More information

Pesticide Analysis by Mass Spectrometry

Pesticide Analysis by Mass Spectrometry Pesticide Analysis by Mass Spectrometry Purpose: The purpose of this assignment is to introduce concepts of mass spectrometry (MS) as they pertain to the qualitative and quantitative analysis of organochlorine

More information

2015-16 BCOE Payroll Calendar. Monday Tuesday Wednesday Thursday Friday Jun 29 30 Jul 1 2 3. Full Force Calc

2015-16 BCOE Payroll Calendar. Monday Tuesday Wednesday Thursday Friday Jun 29 30 Jul 1 2 3. Full Force Calc July 2015 CM Period 1501075 July 2015 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 August 2015 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

More information

UHPLC/MS: An Efficient Tool for Determination of Illicit Drugs

UHPLC/MS: An Efficient Tool for Determination of Illicit Drugs Application Note: 439 UHPLC/MS: An Efficient Tool for Determination of Illicit Drugs Guifeng Jiang, Thermo Fisher Scientific, San Jose, CA, USA Key Words Accela UHPLC System MSQ Plus MS Detector Drugs

More information

Thermo Scientific GC-MS Data Acquisition Instructions for Cerno Bioscience MassWorks Software

Thermo Scientific GC-MS Data Acquisition Instructions for Cerno Bioscience MassWorks Software Thermo Scientific GC-MS Data Acquisition Instructions for Cerno Bioscience MassWorks Software Mark Belmont and Alexander N. Semyonov, Thermo Fisher Scientific, Austin, TX, USA Ming Gu, Cerno Bioscience,

More information

Agilent LCMS products and the application strategies in veterinary drug analysis

Agilent LCMS products and the application strategies in veterinary drug analysis Agilent LCMS products and the application strategies in veterinary drug analysis Experience A New Level of Confidence Ma Xin 马 鑫 LCMS Application Engineer Internal Sales Training - The new 6495 QQQ LC/MS

More information

PosterREPRINT AN LC/MS ORTHOGONAL TOF (TIME OF FLIGHT) MASS SPECTROMETER WITH INCREASED TRANSMISSION, RESOLUTION, AND DYNAMIC RANGE OVERVIEW

PosterREPRINT AN LC/MS ORTHOGONAL TOF (TIME OF FLIGHT) MASS SPECTROMETER WITH INCREASED TRANSMISSION, RESOLUTION, AND DYNAMIC RANGE OVERVIEW OVERVIEW Exact mass LC/MS analysis using an orthogonal acceleration time of flight (oa-tof) mass spectrometer is a well-established technique with a broad range of applications. These include elemental

More information

2013-2014. oct 03 / 2013 nov 12 / 2013. oct 05 / 2013. oct 07 / 2013. oct 21 / 2013. oct 24 / 2013. nov 07 / 2013 nov 14 / 2013.

2013-2014. oct 03 / 2013 nov 12 / 2013. oct 05 / 2013. oct 07 / 2013. oct 21 / 2013. oct 24 / 2013. nov 07 / 2013 nov 14 / 2013. 2013- ACADEMIC CALENDARS SOUTH UNIVERSITY 2013- ACADEMIC CALENDAR Fall 2013 Winter Spring Summer New Student Orientation Session II (Mid ) oct 03 / 2013 nov 12 / 2013 jan 09 / feb 18 / apr 03 / may 13

More information

AS1 MOLES. oxygen molecules have the formula O 2 the relative mass will be 2 x 16 = 32 so the molar mass will be 32g mol -1

AS1 MOLES. oxygen molecules have the formula O 2 the relative mass will be 2 x 16 = 32 so the molar mass will be 32g mol -1 Moles 1 MOLES The mole the standard unit of amount of a substance the number of particles in a mole is known as Avogadro s constant (L) Avogadro s constant has a value of 6.023 x 10 23 mol -1. Example

More information

Computing & Telecommunications Services Monthly Report March 2015

Computing & Telecommunications Services Monthly Report March 2015 March 215 Monthly Report Computing & Telecommunications Services Monthly Report March 215 CaTS Help Desk (937) 775-4827 1-888-775-4827 25 Library Annex helpdesk@wright.edu www.wright.edu/cats/ Last Modified

More information

Atomic Masses. Chapter 3. Stoichiometry. Chemical Stoichiometry. Mass and Moles of a Substance. Average Atomic Mass

Atomic Masses. Chapter 3. Stoichiometry. Chemical Stoichiometry. Mass and Moles of a Substance. Average Atomic Mass Atomic Masses Chapter 3 Stoichiometry 1 atomic mass unit (amu) = 1/12 of the mass of a 12 C atom so one 12 C atom has a mass of 12 amu (exact number). From mass spectrometry: 13 C/ 12 C = 1.0836129 amu

More information

S olid Ph ase Extraction (SP E) Method:

S olid Ph ase Extraction (SP E) Method: Solid Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/ Tandem Mass Spectrometry Toni Hofhine, Horizon Technology,

More information

F321 THE STRUCTURE OF ATOMS. ATOMS Atoms consist of a number of fundamental particles, the most important are... in the nucleus of an atom

F321 THE STRUCTURE OF ATOMS. ATOMS Atoms consist of a number of fundamental particles, the most important are... in the nucleus of an atom Atomic Structure F32 TE STRUCTURE OF ATOMS ATOMS Atoms consist of a number of fundamental particles, the most important are... Mass / kg Charge / C Relative mass Relative Charge PROTON NEUTRON ELECTRON

More information

Environmental Water Testing: Surface Water, Groundwater, Hard Water, Wastewater, & Seawater

Environmental Water Testing: Surface Water, Groundwater, Hard Water, Wastewater, & Seawater Document: AND Sol Env 08 2013 Environmental Water Testing: Surface Water, Groundwater, Hard Water, Wastewater, & Seawater Matrix specific sample preparation and testing methods for environmental waters

More information

Part One: Mass and Moles of Substance. Molecular Mass = sum of the Atomic Masses in a molecule

Part One: Mass and Moles of Substance. Molecular Mass = sum of the Atomic Masses in a molecule CHAPTER THREE: CALCULATIONS WITH CHEMICAL FORMULAS AND EQUATIONS Part One: Mass and Moles of Substance A. Molecular Mass and Formula Mass. (Section 3.1) 1. Just as we can talk about mass of one atom of

More information

For example: (Example is from page 50 of the Thinkbook)

For example: (Example is from page 50 of the Thinkbook) SOLVING COMBINED SPECTROSCOPY PROBLEMS: Lecture Supplement: page 50-53 in Thinkbook CFQ s and PP s: page 216 241 in Thinkbook Introduction: The structure of an unknown molecule can be determined using

More information

Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract

Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract Lirui Qiao, 1 Rob Lewis, 2 Alex Hooper, 2 James Morphet, 2 Xiaojie Tan, 1 Kate

More information

Organic Chemistry Calculations

Organic Chemistry Calculations Organic Chemistry Calculations There are three basic units for measurement in the organic laboratory mass, volume, and number, measured in moles. Most of the other types of measurements are combinations

More information

F321 MOLES. Example If 1 atom has a mass of 1.241 x 10-23 g 1 mole of atoms will have a mass of 1.241 x 10-23 g x 6.02 x 10 23 = 7.

F321 MOLES. Example If 1 atom has a mass of 1.241 x 10-23 g 1 mole of atoms will have a mass of 1.241 x 10-23 g x 6.02 x 10 23 = 7. Moles 1 MOLES The mole the standard unit of amount of a substance (mol) the number of particles in a mole is known as Avogadro s constant (N A ) Avogadro s constant has a value of 6.02 x 10 23 mol -1.

More information

Performing Calculatons

Performing Calculatons Performing Calculatons There are three basic units for measurement in the organic laboratory mass, volume, and number, measured in moles. Most of the other types of measurements are combinations of them,

More information

Chemistry 65 Chapter 6 THE MOLE CONCEPT

Chemistry 65 Chapter 6 THE MOLE CONCEPT THE MOLE CONCEPT Chemists find it more convenient to use mass relationships in the laboratory, while chemical reactions depend on the number of atoms present. In order to relate the mass and number of

More information

TargetQuan 3 Software. Leading the way in regulatory. POPs quantification. Bullet Bullet Bullet

TargetQuan 3 Software. Leading the way in regulatory. POPs quantification. Bullet Bullet Bullet TargetQuan 3 Software Leading the way in regulatory POPs quantification Bullet Bullet Bullet Leading the way in regulatory POPs quantification Analyse Samples Open Sequence Process Sequence Analyse Samples

More information

Problem Solving. Empirical Formulas

Problem Solving. Empirical Formulas Skills Worksheet Problem Solving Empirical Formulas Suppose you analyze an unknown compound that is a white powder and find that it is composed of 36.5% sodium, 38.1% oxygen, and 25.4% sulfur. You can

More information

Technical Report. Automatic Identification and Semi-quantitative Analysis of Psychotropic Drugs in Serum Using GC/MS Forensic Toxicological Database

Technical Report. Automatic Identification and Semi-quantitative Analysis of Psychotropic Drugs in Serum Using GC/MS Forensic Toxicological Database C146-E175A Technical Report Automatic Identification and Semi-quantitative Analysis of Psychotropic Drugs in Serum Using GC/MS Forensic Toxicological Database Hitoshi Tsuchihashi 1 Abstract: A sample consisting

More information

7-5.5. Translate chemical symbols and the chemical formulas of common substances to show the component parts of the substances including:

7-5.5. Translate chemical symbols and the chemical formulas of common substances to show the component parts of the substances including: 7-5.5 Translate chemical symbols and the chemical formulas of common substances to show the component parts of the substances including: NaCl [salt], H 2 O [water], C 6 H 12 O 6 [simple sugar], O 2 [oxygen

More information

Reisevertrieb unter der Lupe: Was buchen die Deutschen wirklich? 1. Travel Sales with a fine-toothed comb: What are Germans actually booking?

Reisevertrieb unter der Lupe: Was buchen die Deutschen wirklich? 1. Travel Sales with a fine-toothed comb: What are Germans actually booking? GfK Gruppe Reisevertrieb unter der Lupe: Was buchen die Deutschen wirklich? 1 Travel Sales with a fine-toothed comb: What are Germans actually booking? ITB Marketing & Sales Day Hery-Charles Eckert GfK

More information

Getting the most from this book...4 About this book...5

Getting the most from this book...4 About this book...5 Contents Getting the most from this book...4 About this book....5 Content Guidance Topic 1 Atomic structure and the periodic table...8 Topic 2 Bonding and structure...14 Topic 2A Bonding....14 Topic 2B

More information

NITRIC OXIDE and NITROGEN DIOXIDE 6014

NITRIC OXIDE and NITROGEN DIOXIDE 6014 NITRIC OXIDE and NITROGEN DIOXIDE 6014 NO MW: 30.01 CAS: 10102-43-9 RTECS: QX0525000 46.01 10102-44-0 QW9800000 METHOD: 6014, Issue 1 EVALUATION: FULL Issue 1: 15 August 1994 OSHA : 25 ppm NO; C 1 ppm

More information

Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS

Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS Stephen Lock 1 and Matthew Noestheden 2 1 AB SCIEX Warrington, Cheshire (UK), 2 AB SCIEX Concord, Ontario (Canada) Overview A rapid,

More information

B i o s o l u t i o n s

B i o s o l u t i o n s B i o s o l u t i o n s Implementation of pharmatracker TM : A case study Prepared by Ocimum Biosolutions Ocimumbio Solutions August 2006 All rights reserved. 2 B i o s o l u t i o n s an ISO 9001:2000

More information

Simple vs. True. Simple vs. True. Calculating Empirical and Molecular Formulas

Simple vs. True. Simple vs. True. Calculating Empirical and Molecular Formulas Calculating Empirical and Molecular Formulas Formula writing is a key component for success in chemistry. How do scientists really know what the true formula for a compound might be? In this lesson we

More information

Job posting. other. Fourteen Research Positions in bio-diagnosis and chemical structure elucidation (13 PhD students and 1 postdoc)

Job posting. other. Fourteen Research Positions in bio-diagnosis and chemical structure elucidation (13 PhD students and 1 postdoc) Job posting Type of position scientific administrative Target group graduates post docs other Title Institution Fourteen Research Positions in bio-diagnosis and chemical structure elucidation (13 PhD students

More information

The Mole and Molar Mass

The Mole and Molar Mass The Mole and Molar Mass 1 Molar mass is the mass of one mole of a substance. Molar mass is numerically equal to atomic mass, molecular mass, or formula mass. However the units of molar mass are g/mol.

More information

Proficiency Testing In A Global Analytical Environment Benefits & Challenges. AOAC September 2007

Proficiency Testing In A Global Analytical Environment Benefits & Challenges. AOAC September 2007 Proficiency Testing In A Global Analytical Environment Benefits & Challenges AOAC September 2007 1 The Coca-Cola Company The Coca-Cola Company is the largest manufacturer, distributor and marketer of nonalcoholic

More information

HP ArcSight User Behavior Analytics

HP ArcSight User Behavior Analytics Insider Threat HP ArcSight User Behavior Analytics Application Misuse Sensitive Data Access Hakan Durgut ArcSight Specialist Nordics/Baltics 1 The insider threat challenge IT Security focus in on the external

More information

Moles and Chemical Reactions. Moles and Chemical Reactions. Molar mass = 2 x 12.011 + 6 x 1.008 + 1 x15.999 = 46.069 g/mol

Moles and Chemical Reactions. Moles and Chemical Reactions. Molar mass = 2 x 12.011 + 6 x 1.008 + 1 x15.999 = 46.069 g/mol We have used the mole concept to calculate mass relationships in chemical formulas Molar mass of ethanol (C 2 H 5 OH)? Molar mass = 2 x 12.011 + 6 x 1.008 + 1 x15.999 = 46.069 g/mol Mass percentage of

More information

Sample Preparation. Consider the aqueous samples from Lake Nakuru, and discuss the following questions.

Sample Preparation. Consider the aqueous samples from Lake Nakuru, and discuss the following questions. Sample Preparation Purpose: The purpose of this assignment is to address questions related to the sample preparation portion of EPA method 525-2 for measurement of organochlorine pesticides by GC-MS. Learning

More information

Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography

Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography INTRODUCTION The analysis of soft drinks for caffeine was able to be performed using UV-Vis. The complex sample

More information

Interest Rates. Countrywide Building Society. Savings Growth Data Sheet. Gross (% per annum)

Interest Rates. Countrywide Building Society. Savings Growth Data Sheet. Gross (% per annum) Interest Rates (% per annum) Countrywide Building Society This is the rate of simple interest earned in a year (before deducting tax). Dividing by 12 gives the monthly rate of interest. Annual Equivalent

More information

Beware that Low Urine Creatinine! by Vera F. Dolan MSPH FALU, Michael Fulks MD, Robert L. Stout PhD

Beware that Low Urine Creatinine! by Vera F. Dolan MSPH FALU, Michael Fulks MD, Robert L. Stout PhD 1 Beware that Low Urine Creatinine! by Vera F. Dolan MSPH FALU, Michael Fulks MD, Robert L. Stout PhD Executive Summary: The presence of low urine creatinine at insurance testing is associated with increased

More information

A new concept for isotope ratio monitoring LC/MS. A Wide Range of Applications

A new concept for isotope ratio monitoring LC/MS. A Wide Range of Applications A new concept for isotope ratio monitoring LC/MS A Wide Range of Applications Andreas Hilkert, Dieter Juchelka, Michael Krummen Thermo Electron (Bremen) GmbH Overview Introduction in Isotope Ratio Monitoring-LC/MS

More information

Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening

Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening Application Note Forensics Author Erin Shonsey Director of Research Alabama Department of Forensic Science Abstract

More information

EPA Radionuclides Rule and the RadNet Program

EPA Radionuclides Rule and the RadNet Program EPA Radionuclides Rule and the RadNet Program Kelly Moran (215) 814-2331 moran.kelly@epa.gov 7/20/2011 U.S. Environmental Protection Agency 1 What is a radionuclide (radioisotope)? element - any one of

More information

Chapter 3: Stoichiometry

Chapter 3: Stoichiometry Chapter 3: Stoichiometry Key Skills: Balance chemical equations Predict the products of simple combination, decomposition, and combustion reactions. Calculate formula weights Convert grams to moles and

More information

Overview. Triple quadrupole (MS/MS) systems provide in comparison to single quadrupole (MS) systems: Introduction

Overview. Triple quadrupole (MS/MS) systems provide in comparison to single quadrupole (MS) systems: Introduction Advantages of Using Triple Quadrupole over Single Quadrupole Mass Spectrometry to Quantify and Identify the Presence of Pesticides in Water and Soil Samples André Schreiber AB SCIEX Concord, Ontario (Canada)

More information

How much does a single atom weigh? Different elements weigh different amounts related to what makes them unique.

How much does a single atom weigh? Different elements weigh different amounts related to what makes them unique. How much does a single atom weigh? Different elements weigh different amounts related to what makes them unique. What units do we use to define the weight of an atom? amu units of atomic weight. (atomic

More information

Climatography of the United States No. 20 1971-2000

Climatography of the United States No. 20 1971-2000 Climate Division: CA 2 NWS Call Sign: SAC Month (1) Min (2) Month(1) Extremes Lowest (2) Temperature ( F) Lowest Month(1) Degree s (1) Base Temp 65 Heating Cooling 100 Number of s (3) Jan 53.8 38.8 46.3

More information

P/T 2B: 2 nd Half of Term (8 weeks) Start: 26-AUG-2013 End: 20-OCT-2013 Start: 21-OCT-2013 End: 15-DEC-2013

P/T 2B: 2 nd Half of Term (8 weeks) Start: 26-AUG-2013 End: 20-OCT-2013 Start: 21-OCT-2013 End: 15-DEC-2013 2013-2014 SPECIAL TERM ACADEMIC CALENDAR FOR SCRANTON EDUCATION ONLINE (SEOL), MBA ONLINE, HUMAN RESOURCES ONLINE, NURSE ANESTHESIA and ERP PROGRAMS SPECIAL FALL 2013 TERM Key: P/T = Part of Term P/T Description

More information

CHAPTER 8: CHEMICAL COMPOSITION

CHAPTER 8: CHEMICAL COMPOSITION CHAPTER 8: CHEMICAL COMPOSITION Active Learning: 1-4, 6-8, 12, 18-25; End-of-Chapter Problems: 3-4, 9-82, 84-85, 87-92, 94-104, 107-109, 111, 113, 119, 125-126 8.2 ATOMIC MASSES: COUNTING ATOMS BY WEIGHING

More information

P/T 2B: 2 nd Half of Term (8 weeks) Start: 25-AUG-2014 End: 19-OCT-2014 Start: 20-OCT-2014 End: 14-DEC-2014

P/T 2B: 2 nd Half of Term (8 weeks) Start: 25-AUG-2014 End: 19-OCT-2014 Start: 20-OCT-2014 End: 14-DEC-2014 2014-2015 SPECIAL TERM ACADEMIC CALENDAR FOR SCRANTON EDUCATION ONLINE (SEOL), MBA ONLINE, HUMAN RESOURCES ONLINE, NURSE ANESTHESIA and ERP PROGRAMS SPECIAL FALL 2014 TERM Key: P/T = Part of Term P/T Description

More information

Prentice Hall. Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition. High School. High School

Prentice Hall. Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition. High School. High School Prentice Hall Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition High School C O R R E L A T E D T O High School C-1.1 Apply established rules for significant digits,

More information

P/T 2B: 2 nd Half of Term (8 weeks) Start: 24-AUG-2015 End: 18-OCT-2015 Start: 19-OCT-2015 End: 13-DEC-2015

P/T 2B: 2 nd Half of Term (8 weeks) Start: 24-AUG-2015 End: 18-OCT-2015 Start: 19-OCT-2015 End: 13-DEC-2015 2015-2016 SPECIAL TERM ACADEMIC CALENDAR For Scranton Education Online (SEOL), Masters of Business Administration Online, Masters of Accountancy Online, Health Administration Online, Health Informatics

More information

Student Review Sheet Matter & Energy Semester B Examination

Student Review Sheet Matter & Energy Semester B Examination Matter & Energy Semester B Examination Test Description Length: 2 hours Items: 59 SR (~85%), 2 BCRs (~15%) Unit Approximate Number of Selected Response Items Science Process Skills 13 Molecules to Atoms

More information

MASS RELATIONSHIPS IN CHEMICAL REACTIONS

MASS RELATIONSHIPS IN CHEMICAL REACTIONS MASS RELATIONSHIPS IN CHEMICAL REACTIONS 1. The mole, Avogadro s number and molar mass of an element. Molecular mass (molecular weight) 3. Percent composition of compounds 4. Empirical and Molecular formulas

More information