ISOO FINAL PROGRAM. June 16-19, 2015 Paris, France. Congress Organizer: Laurence Desjardins

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1 ISOO 2015 June 16-19, 2015 Paris, France FINAL PROGRAM Congress Organizer: Laurence Desjardins

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3 FINAL PROGRAM LOCAL ORGANIZING COMMITTEE Laurence DESJARDINS Nathalie CASSOUX François DOZ ISOO BOARD MEMBERS Carol SHIELDS, President Arun SINGH, Vice President Mandeep SAGOO, Secretary Katherine PATON, Treasurer Michael GIBLIN, Membership Committee Chair Laurence DESJARDINS, Membership Committee Hayyam KIRATLI, Membership Committee Maria MANQUEZ, Membership Committee Katherine PATON, Membership Committee Tero KIVELA, Bylaws Committee Doris HADJISTILIANOU, Program Committee Bertil DAMATO, International Council of Ophthalmology Representative ADVISORY BOARD Norbert BORNFELD Bertil DAMATO François DOZ Michael GIBLIN Santosh HONAVAR Martine JAGER Akahiro KANEKO Tero KIVELA Francis MUNIER Masood NASERIPOUR Jerry SHIELDS Rand SIMPSON Luiz TEIXEIRA Leonidas ZOGRAFOS CONGRESS OVERVIEW TUESDAY JUNE 16 WEDNESDAY JUNE 17 THURSDAY JUNE 18 FRIDAY JUNE 19 Amphitheatre Berlioz level 1&2 Welcome Address 8h-8h10 Retinoblastoma free papers 8h10-10h00 10h30-11h30 Round Table Indications on Enucleation 11h30-12h30 14h30-15h30 Stallard lecture Linn Murphree 16h00-16h30 Room Molière level 3 Retinoblastoma free papers 8h30-10h00 Coffee break in the exhibition 10h00-10h30 Lunch in Hall Menand 12h30-13h30 FCI symposium 13h30-14h30 14h30-15h30 Coffee break in the exhibition 15h30-16h00 Hall Menand level -1 Poster session 13h30-14h30 P1-P54 Amphitheatre Berlioz level 1&2 Uveal Melanoma 8h00-10h00 Round Table discussion Management of small melanocytic tumors 10h30-11h20 11h20-12h30 Room Molière level 3 Uveal Melanoma 8h00-10h00 Coffee break in the exhibition 10h00-10h30 Lunch boxes in the exhibition area 12h30-13h00 Words from our sponsors 14h-14h30 14h30-15h30 Coffee break in the exhibition 15h30-16h00 Invited Speaker Sophie Piperno-Neumann 16h00-16h30 Hall Menand level -1 Poster session P55-P102 13h00-14h00 Amphitheatre Berlioz level 1&2 8h00-10h00 Coffee break in the exhibition 10h00-10h30 Controversy of the day Genetic prognostic testing performed in uveal melanoma 10h30-11h30 ISOO Business Meeting 11h30-12h30 Lunch in Hall Menand 12h30-13h30 13h30-15h30 Coffee break in the exhibition 15h30-16h00 Invited Speaker Marc-Henri Stern 16h00-16h45 Room Molière level 3 Cours d oncologie Oculaire réservé aux membres de la SFO 9h00-10h20 Coffee break 10h20-11h00 Cours d oncologie Oculaire réservé aux membres de la SFO 11h00-12h30 Lunch boxes 12h30-14h00 Cours d oncologie Oculaire réservé aux membres de la SFO 14h00-16h00 Coffee break 16h00-16h30 Amphitheatre Berlioz level 1&2 8h00-10h00 Hall Menand level -1 Coffee break in the exhibition 10h00-10h30 10h30-12h30 Lunch boxes in the exhibition area 12h30-13h30 14h30-15h30 Coffee break in the exhibition 15h30-16h00 Invited Speaker Serge Morax 16h00-16h30 Poster session 13h30-14h30 P103 - P151 Controversy of the day IAC vs IC Chemotherapy 16h30-17h30 16h30-17h30 Round table Topical therapy for malignant conjunctival tumors 16h45-17h30 Cours d oncologie Oculaire réservé aux membres de la SFO 16h30-18h00 Case report session 16h30-17h30 17h30-18h30 Case report session 17h30-18h30 Case report session 17h30-18h30 Case Report session 18h30-19h30 Welcome Cocktail in the Congress venue 19h30-20h30 Dining Cocktail in Paris Hotel de Ville 20h00-22h00 Dinner cruise on the Seine river 19h00-23h00

4 ISOO President Welcome Address Bienvenue à Paris (Welcome to Paris)! The program committee and I wholeheartedly welcome all of you to the enchanting city of Paris, the City of Light, named so because of its leadership during the Age of Enlightenment and also for its adaptation of gas street lighting in the 1860s. Paris is an absolutely remarkable city, sprinkled with magnificent architectural icons, delectable cuisine, stylish boutiques, and, most notably, an out-of-this-world treasure of priceless art. Paris The location of the wrought-iron lattice Eiffel Tower, erected in 1889 as the entrance arch for the World s Fair. The site of the powerful Arc de Triomphe de l Etoile on the Champs-Elysees, honoring those who fought and died for France during the French Revolutionary and Napoleonic Wars. The nest of the French Gothic Notre Dame Cathedral, gargoyled in religious history and home to the Hunchback of Notre Dame. The paragon home of the Louvre Museum, the world s most visited museum, with an enormous and priceless collection of art from the centuries. However, it should be known that Paris is also a City of Medicine. The oldest hospital in Paris dates back to 651 AD, the Hotel-Dieu (Hostel of God). This landmark is the oldest hospital in the world still operating. Another medical jewel in Paris is the Curie Institute, with a focus on research, teaching, and cancer management. This institute boasts 5 Nobel laureates, advanced radiotherapy and chemotherapy divisions, and serves as a referral center for numerous cancers, including a world-class eye cancer center. So here we are in this magnificent city of Paris, hosted by Dr. Laurence Desjardin and her team. This meeting promises to be educational and spirited with a spectacular program viewing topics ranging from biopsy and prognostication of choroidal melanoma to the role of anti vascular endothelial growth factors for radiation complications to outcomes of intravitreal chemotherapy for retinoblastoma. And more to come exciting and controversial panels will discuss lively topics of the pros and cons of intra-arterial chemotherapy versus intravenous chemotherapy for retinoblastoma, endoresection with or without preceding radiotherapy for uveal melanoma, what type of genetic test is best for uveal melanoma, and the ideal management of small borderline melanocytic choroidal tumors. We will learn from our gifted keynote speakers: Dr. A. Linn Murphree on Retinoblastoma management in 2015, Dr. Sophie Piperno-Neumann on Recent advances in systemic treatment of uveal melanoma, Dr. Marc-Henri Stern on Genetic landscape of uveal melanoma, and Dr. Serge Morax on Recent improvement in the management of orbital tumors. How s that for a line-up! So, get ready to listen, learn, and participate in this well-planned didactic cornucopia of topics. This meeting promises to be memorable both scientifically and socially. We assure you that you will be enlightened, here in the City of Light. On behalf of Dr. Laurence Desjardins and her steering committee, we welcome you to Paris. Savor every moment and profitez de la reunion (enjoy the meeting)! Avec mes meilleures salutations (With best regards), Carol L. Shields, M.D. President, The International Society of Ocular Oncology Local Host Welcome Address Dear Delegates, It is a great pleasure and honor for me to welcome you to the 17th Biennal meeting of the International Society of Ophthalmic Oncology in Paris. My interest into ophthalmic oncology started during my residency when I worked in New York with Bob Ellsworth and David Abramson in I had the opportunity to participate in most ophthalmic oncology meeting since Schwerin in Ophthalmic tumors are rare and ophthalmic oncologists get to know each other and collaborate more than other specialists, because of the small number of people involved in each country. So our meetings are an opportunity not only to learn new things about ophthalmic tumors but also to meet good friends. The ophthalmic oncology community is debtor to Jerry Shields who has formalized our society and has made her become such a big organization. For this meeting I have tried to give enough time for each presentation so that there will be possible discussion for each. We shall have 3 poster sessions with poster prizes. During the sessions we have saved some time for round tables and controversies about some of the most difficult subjects. We encourage everybody to participate to the discussions. I hope everyone will enjoy the sessions as well as the social program. I thank Paul Finger from the eye cancer foundation and the ISOO committee for their help in making it possible for some ophthalmologists from developing countries to participate. I thank Sandy and Tika from the ophthalmic oncology service of Philadelphia who have made a wonderful job with the web site and abstracts I want to also thank Doris Hadjistilianou who helped me to validate the program but also the Europa Society, our sponsors and the SFO who made this possible. Welcome to Paris and have a good meeting! Laurence Desjardins 4

5 STALLARD LECTURE INVITED SPEAKERS Linn Murphree Professor of Ophthalmology and Pediatrics Keck School of medicine, USC Director of the USC Ocular Oncology Service and the CHLA Retinoblastoma Programm Pr Linn Murphree is Professor of Ophthalmology and Pediatrics Keck School of medicine, USC and Director of the USC Ocular Oncology Service and the CHLA Retinoblastoma. Following his training in human genetics as a Fulbright Fellow in Human Genetics at the University of Copenhagen, he entered his medical training at Baylor College of Medicine with an established interest in Human Genetics. He discovered ophthalmology in medical school as well as an abiding interest in pediatrics. He combined those three interests by focusing during his Ophthalmology Residency on ophthalmic genetic diseases including retinoblastoma. He assumed the position of Head, Pediatric Ophthalmology in the USC Department of Ophthalmology and Head, Ophthalmology at Children s Hospital Los Angeles upon completion of his fellowship in Pediatric Ophthalmology at John Hopkins Hospital. With his first NIH grant he demonstrated by deletion mapping that the RB1 gene was located in 13q14. Subsequently he developed a clinical referral practice focused on Ocular Oncology and developed the largest retinoblastoma referral center west of the Mississippi. During his retinoblastoma clinical practice, he recognized an unmet clinical need for a wide-field retinal camera to document the intraocular findings associated with retinoblastoma. He recruited a team of engineers and collaborated with optical engineers in private industry. The result was the invention of the RetCam the commercially available pediatric retinal camera used world wide to document not only retinoblastoma but also many other retinal abnormalities including retinopathy of prematurity. The RetCam III is currently licensed and marketed by Clarity Medical Systems, Inc His work on chemo thermotherapy published in 1983 was a model for retinoblastoma treatments using chemotherapy IV combined with local treatments. He was author or coauthor of more than 70 major papers on retinoblastoma genetic and retinoblastoma Care. Sophie Piperno-Neumann MD Institut Curie Paris, France After a Board certification in Medical Oncology, Sophie Piperno-Neumann completed a fellowship in Medical Oncology at Avicenne Hospital and pursued as Assistant Professor at Paris XIII University. In 2001, she joined the Medical Oncology department at Institut Curie, and is currently in charge of sarcoma and uveal melanoma patients. Her work has focused on translational and clinical research in the field of uveal melanoma, co-leading the translational program dedicated to this field at Institut Curie for 2 years. She is a member of the American Society of Clinical Oncology (ASCO), the International Society of Ocular Oncology (ISOO) and the Ophthalmic Oncology Group (OOG), and is an active member of the Bone and Soft Tissue Sarcoma Group (STBSG) and the Melanoma Group of the European Organization for Research and Treatment of Cancer (EORTC) since Marc-Henri Stern Marc-Henri Stern is head of a research team in the U830 Inserm unit at Institut Curie in Paris. He received his M.D. and Ph.D. degrees from Paris Universities (France). After his post-doctoral training at the N.C.I. (Bethesda, Maryland, USA), he started his research team at Hôpital Saint Louis, Paris focused on leukemogenesis and DNA repair defects. He joined Institut Curie in 2000, pursuing with his team a basic and translational approaches of different solid tumours, in particular breast and ovarian carcinomas and uveal melanoma, based on his expertise in genetics and genomics. He is author or coauthor of over 70 peer-reviewed articles. He actively participates at Institut Curie to a multidisciplinary group of scientists and doctors devoted to uveal melanoma research. Marc-Henri Stern will be in charge of the large scale sequencing of the project. Serge Morax - Ophtalmologist competent in maxillo-facial and plastic reconstructive surgery - Head of Department Ophtalmology and Ocular Plastic Surgery at the Rothschild Ocular Foundation ( ) - Associated Professor at the College of Medecine (2002) - President of ESOPRS (European Society of Ophthalmic Plastic and Reconstructive Surgery ) - President of the French Society of orbit, lids and lachrymal gland Plastic and reconstructive Surgery ( ) - Co-reporter in the French Society of Ophtalmology of the book entitled orbit and lid pathology (1998) 5

6 There will be poster sessions Tuesday, Wednesday and Friday at lunch time. Except rapid fire and case report sessions, each paper should be 7 minutes followed by 3 minutes discussion. SCIENTIFIC PROGRAM TUESDAY JUNE 16 08h00 Room: Amphitheatre Berlioz Introduction and Welcome Address by President Carol Shields 08h10-10h00 Room: Amphitheatre Berlioz Retinoblastoma Free Papers Chairs: Carol Shields, Charlotta Erikkson 8h10 Trilateral retinoblastoma screening: is diffusion weighted magnetic resonance imaging helpful? Ira Dunkel, Jasmine Francis, Brian Marr, David Abramson, Sofia Haque 8h20 Trilateral retinoblastoma: a systematic review and meta-analysis of incidence and survival. Annette Moll, Marcus de Jong, Tero Kivela, Jonas Castelijns, Machteld Bosscha, Pim de Graaf, Arjenne Kors 8h30 Secondary neoplasms after retinoblastoma treatment. Shigenobu Suzuki 8h40 Incidence of second primary cancer in heritable and non-heritable retinoblastoma: Results from a Danish population based study with more than 70 years follow-up. Pernille Axél Gregersen, Jan Alsner, Jens Overgaard, Mikkel Funding, Steen Fiil Urbak 8h50 Elevated risk of developing sarcoma and leukemia in children and adolescence after retinoblastoma treatment. Petra Temming, Anja Viehmann, Marina Arendt, Lewin Eisele, Claudia Spix, Norbert Bornfeld, Wolfgang Sauerwein, Karl-Heinz Jöckel, Dietmar Lohmann 9h00 Cranio-facial second primary tumors in hereditary retinoblastoma patients previously treated with external beam radiotherapy. Irene Jiménez, Marick Laé, Alexia Savignoni, Laurence Desjardins, François Doz, Hervé Brisse, Isabelle Aerts 9h10 Long-Term Outcomes of Group B Eyes in Retinoblastoma Patients Treated with Short-Course Chemoreduction: The Children s Hospital Los Angeles Experience. Jesse Berry, Thomas Lee, Rima Jubran, A. Linn Murphree, Jonathan Kim 9h20 Risk profiles for postlaminar optic nerve invasion and massive choroidal invasion of retinoblastoma based on intraocular tumor size. Marcus de Jong, Fenna van der Meer, Sophia Goericke, Hervé Brisse, Paolo Galluzzi, Philippe Maeder, Selma Sirin, Sonia De Francesco, Xavier Sastre-Garau, Klaus Metz, Alfonso Cerase, Daan Noij, Paul van der Valk, Annette Moll, Jonas Castelijns, Pim de Graaf 9h30 Histopathologic Grading of Anaplasia in Retinoblastoma. Grossniklaus Hans, Pia Mendoza, Charles Specht, Michael Lynn, Qing Zhang, Jun Kong 9h40 Prognostic significance of minimal dissemination detection in retinoblastoma. Ana Torbidoni, Viviana Laurent, Claudia Sampor, Daniela Ottaviani, Valeria Vazquez, Mariano Gabri, María de Davila, Marco Ramirez, Cristina Alonso, Daniel Alonso, Jorge Rossi, Guillermo Chantada 9h50 Comparison of Clinical Classification Systems of Retinoblastoma with Histopathology Of Primarily Enucleated Eyes. Payal Shah, Roshmi Gupta, Ashwin Mallipatna 08h30-10h00 Room: Molière Retinoblastoma Free Papers - Parallel session Chairs: Nathalie Cassoux, Claude Houdayer, Brenda Gallie 8h30 The role of chromosomal shattering (chromothripsis) in retinoblastoma tumorigenesis. Rachel Brenna, Justina McEvoy, Armita Bahrami, Elizabeth Stewart, Matthew W. Wilson, Michael Dyer 8h40 Global Genetics: A novel approach to development and delivery of retinoblastoma genetic services. Helen Dimaras, Tim Corson, Junyang Zhao, Lucy Njambi, Jessica Hill, Li Qun He, Trillilum Chang 8h50 What difference does next generation sequencing make to retinoblastoma genetic testing? Hilary Racher, Sharlene Koroscil, Crystal D Silva, Xue Wu, Chao Zhang, Xiaofang Huang, Franny Jewett, Yang Shao, Brenda Gallie 9h00 Kif14 overexpression accelerates tumor development in the TAg-RB transgenic model of retinoblastoma. Tim Corson, Michael O Hare, Mehdi Shadmand 9h10 Inhibition of MMP-2 and MMP-9 Decreases Cellular Proliferation, Angiogenesis and Invasive Potential in Retinoblastoma. Matthew W. Wilson, Anderson Webb, Nabil Saleh, Bradley Gao, Ryan Lee, Justin Lendermon, Rajini Bheemreddy, Quihua Zhang, Michael Dyer, Rachel Brennan, Jena Steinle, Vanessa Morales-Tirado 9h20 MycN amplification, Alternate RB Inactivation pathway and Retinoblastoma. Arupa Ganguly, Kathryn Ewens, Jennifer Richards-Yutz, Kimberly Moran, Juliana Purrazzella, Carol Shields, Ralph Eagle 9h30 Different Clinical And Histopathological Grades Of Retinoblastoma Express Unique Gene Expression And Metabolomic Signatures. Ashwin Mallipatna, Nilanjan Guha, Deepak SA, Syed Lateef, Vishnu Suresh Babu, Seetaraman Gundimeda, Rohit Shetty, Arkasubhra Ghosh 9h40 Genetic mutation testing for retinoblastoma in China. Junyang Zhao, Marc Zhao, Brenda Gallie, Franny Jewett 6

7 TUESDAY JUNE 16 9h50 Extramedullary Hematopoiesis in Retinoblastoma. Patricia Chevez-Barrios, April Ewton, Murali Chintagumpala, Jonathan Kim, Amy Leverant, Dan Gombos 10h00 Coffee break and visit of the Exhibition 10h30-11h30 Room: Amphitheatre Berlioz Retinoblastoma Free Papers Chairs: Santosh Honanavar, Doris Hadjistilianou 10h30 Five year experience of intra-arterial chemotherapy in London. Judith Kingston, Cat Duncan, Fergus Robertson, Jane Herod, Adam Rennie, Tanzina Chowdhury, M. Aschwin Reddy, Mandeep Sagoo, John Hungerford 10h40 Prevention of visual loss and complications following Intra-Arterial Chemotherapy. M. Aschwin Reddy, Judith Kingston, Zish Naeem, Cat Duncan, Fergus Robertson, Adam Rennie, Alki Liasis, Dorothy Thompson, Mandeep Sagoo 10h50 Treatment of recurrent or progressive intraocular retinoblastoma: final results of a national phase II study of the Swiss pediatric oncology group. Maja Beck-Popovic, Stefano Binaghi, Marie-Claire Gaillard, Manuel Diezi, Emma Garcia, Susan Houghton, Maria-Teresa Galley, Margaux Cornu, Sandro Pampallona, Francis Munier 11h00 Intra-arterial chemotherapy for retinoblastoma: A systematic review. Brenda Gallie, Sameh Elsayed Soliman, Yacoub Yousef, Paulita Pamela Astudillo, Priya Durairaj, Helen Dimaras, Helen Chan, Elise Heon, Furqan Shaikh 11h10 Enucleate or Not? Psycho-social and economic impacts in advanced unilateral intraocular retinoblastoma. Sameh Elsayed Soliman, Ahmed Souka, Helen Dimaras, Mona Ashry, Brenda Gallie 11h20 Advanced unilateral retinoblastoma: is the burden of conservative management justified. Laurence Desjardins, Livia Lumbroso-Le Rouic, Christine Levy-Gabriel, François Doz, Isabelle Aerts, Xavier Sastre, Hervé Brisse, Nathalie Cassoux 11h30-12h30 Room: Amphitheatre Berlioz Round table discussion 30 minutes panel discussion and 30 minutes discussion with the audience Indications for Enucleation for Retinoblastoma Moderator: Anette Moll Jerry Shields, Livia Lumbroso-Le Rouic, M. Aschwin Reddy, Santosh Honavar, J. Kim, Dan Gombos 12h30 Lunch in Hall Menand 13h30-14h30 Room: Molière FCI symposium The techniques of biopsies for intraocular uveal melanoma 1. Transcleral biopsies. Edoardo Midena 2. Transvitreal biopsy. Celia Mashi 3. Techniques of transcleral and transvitreal biopsies in San Franciso. Bertil Damato 4. Techniques of biopsies in Curie Institute. Nathalie Cassoux 13h30-14h30 Posters Session Room: Hall Menand Posters 1 to Intraarterial chemotherapy for retinoblastoma as a primary or second therapy: first 3 years Experience of a single center from Istanbul. Samuray Tuncer 2- Chemotherapy related toxicities in three prospective retinoblastoma clinical trials: a children s oncology group (COG) report. Murali Chintagumpala, Rima Jubran, Ann-Marie Leahey, Mark Krailo, Debra Friedman 3- Visual outcome in retinoblastoma: efficacy of amblyopia treatment. Marie Claire Gaillard, Yousra Falfoul, Ali Dinari,Christina Stathopoulos, Pierre-François Kaeser, Francis Munier 4- The effect of ophthalmic artery chemosurgery on immune Function Status in Retinoblastoma Patients with Intra Ocular disease. Cheryl Fischer, Mary Petriccione, Stephanie Vitolano, Edith Guarini, Mary Elisabeth Davis, Y Pierre Gobin, David Abramson, Ira Dunkel 5- Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: response, complications and visual outcome in four cases. Tanzina Chowdhury, Zish Naeem, Judith Kingston, Cat Duncan, Alki Liasis, Dorothy Thompson, Shaban Chaudhry, M. Aschwin Reddy, Mandeep Sagoo, Shabana Chaudhry 6- Relapse rate an Evolution of Cavitary Retinoblastoma tumours treated with systemic chemotherapy. M. Aschwin Reddy, Judith Kingston, Mandeep Sagoo 7- Impact of Prospective Occupational Therapy Evaluations For rehabilitation Needs of children with retinoblastoma. Ibrahim Qaddoumi, Jessica Sparrow, Rachel Brennan, Shenghua, Mao, Kirsten Ness, Carlos Rodriguez-Galindo, Matthew Wilson 8- ERG Outcomes after OAC for retinoblastoma in Eyes with Poor ERGs at Baseline. Scott Brodie, Jasmine Francis, Brian Marr, Y Pierre Gobin, Ira Dunkel, David Abramson 9- Peripheral Intravenous Access is Safe and Sufficient for Delivery of Systemic Chemotherapy for Retinoblastoma. Ann-Marie Leahey, Concetta Di Domenico 10- Risk factors for cutaneous melanoma after retinoblastoma. Ruth Kleinerman, Lindsay Morton, Peggy Tucker, Jeannette Wong 11- Worldwide enucleation techniques and material for treatment of retinoblastoma- an international survey. Daphne Mourits, Dyonne Hartong, Machtel Bosscha, Roel Kloos, Anette Moll 12- The frequency and prevalence of retinoblastoma in Uzbekistan. Ziyavuddin Ismalov, Rustam Usmanov 7

8 TUESDAY JUNE Intravitreous and selective intraarterial melphalan in organsaving treatment of retinoblastoma in children for group C and D. Tatiana Ushakova, Olga Gorovtsova, Igor Trofimov, Yarovoy Andrey, Olga Krikovyaz, Svetlana Saakyan, Olga Ivanova, Boris Dolgushin, Vladimir Polyakov 14- Glycoconjugated porphyrin dimers for a two-photon photodynamic therapy application against retinoblmastoma. Nathalie Cassoux, Su Chen, Guillaume Garcia, Stéphanie Lemaitre, Philippe Maillard 15- Dual agent intra-vitreal chemotherapy (IVC) appears to be superior to single agent IVC in the treatment of relapsed intraocular retinoblastoma. Helen Jenkinson, Manoj Parulekar, Carol Hitchcott, Sarah Turner, Maureen McCalla, John Ainsworth 16- OCT images after intra-arterial and intra-vitreous chemotherapy for retinoblastoma. Shigenobu Suzuki 17- Can sympathetic ophthalmia be a sign of high-risk pathology in advanced unilateral retinoblastoma? Payal Shah, Punith Poornachandra, Padmamalini Mahendradas, Ashwin Mallipatna 18- Rare second cancer in retinoblastoma patient after 14 years. Usha Singh, Vaneet Singh, Rakesh Kapoor 19- MYCN Amplification in a Patient with Locally Aggressive Bilateral Retinoblastoma. Rachel Brennan, Brian Tse, Armita Bahrami, Brent Orr, Matthew W. Wilson 20- Retrograde Differentiation. Jesse Berry, Jonathan Kim, A. Linn Murphree 21- Residual disease monitoring in a retinoblastoma by PCR of a novel deletion breakpoint. Tim Corson, Hilary Racher, Bob Argiropoulos, Helen Chan, Brenda Gallie, Renée Perrier, Donco Matevski, Diane Rushlow, Furqan Shaikh, Heather Trang 22- Patterns of subretinal fluid resolution during chemoreduction in Group D retinoblastoma. Jonathan Kim, Jesse Berry,Thomas Lee, A. Linn Murphree, Rima Jubran, Grace Shih 23- Proliferative vitreoretinopathy in treated retinoblastoma. Jill Wells, Cindy Hwang, Pia Mendoza, G. Baker Hubbard, Grossniklaus Hans 24- Intra-arterial chemotherapy rescue for recurrent or persistent subretinal seeds in retinoblastoma: Tumor control and globe salvage in 30 eyes. Emil Anthony Say, Prashanth Iyer, Murat Hasanreisoglu, Sara Lally, Pascal Jabbour, Jerry Shields, Carol Shields 25- Increase of intraocular pressure in retinoblastoma. Ziyavuddin Islamov 26- Optical Coherence Tomography Enables Imaging of Tumor Initiation and Volumetric Quantification of the TAg-RB Mouse Model of Retinoblastoma. Tim Corson, Andrea Wenzel, Michael O Hare, Mehdi Shadmand 27- Treatment of retinoblastoma: the Institut Curie experience on a series of 730 patients (1995 to 2009). Livia Lumbroso-Le Rouic, Alexia Savignoni, Christine Levy-Gabriel, Isabelle Aerts, Nathalie Cassoux, Flore Salviat, Nathalie Algret, Marion Gauthier-Villars, Paul Freneaux, Hervé Brisse, Remi Dendale, Marc Esteve, François Doz, Laurence Desjardins 28- Blood flow velocity in monocular retinoblastoma assessed by color doppler. Maria Teresa Brizzi Chizzotti Bonanomi, Osmar Saito, Patricia Lima, Roberta Bonanomi 29- Retinoblastoma: Evidence for Stage-Based Chemotherapy. Arun Singh, Charlotte Chung, Carlos Medina, Hassan Abdul Aziz 30- Anesthetic complications during general anesthesia without intravenous access for ophthalmologic oncology exam: Assessment of 5216 cases. Vittoria Arslan-Carlon, David Abramson, Chun Wai Hung 31- Retinoblastoma Knowledge in Familial retinoblastoma: Does it suffice? Mostafa ElManhaly, Brenda Gallie, Helen Dimaras, Sameh Elsayed Soliman 32- Identical triplets with retinoblastoma: One year follow up. Sameh Elsayed Soliman, Helen Chan, Brenda Gallie, Elise Heon 33- Retinal toxicity of intravitreal topotecan for the treatment of retinoblastoma. Grace Liu, Jasmine Francis, David Abramson Brian Marr Scott Brodie 34- Intraarterial and intravitreal chemotherapy: An step forward in the management of retinoblastoma. Jaume Català-Mora, Jesús Díaz-Cascajosa, Andreu Parareda, Guillermo Chantada, Teresa Sola 35- Pathologic Risk-Based Adjuvant Chemotherapy for Unilateral Retinoblastoma Following Enucleation. Ibrahim Qaddoumi, Rachel Brennan, Carlos Rodriguez-Galindo, Matthew W. Wilson 36- Clinical Presentation and Outcome of Retinoblastoma (Rb) in Older Patients - A Comparative Study. Fairooz Manjandavida, Santosh Honavar, VijayAnand, P. Reddy 37- Oncogenic human papilloma virus in sporadic retinoblastoma. Usha Singh, Ritu Aggarwal, Deepak Bansal 38- The Predictive Value of TNM Classification, The International Classification, and Reese-Ellsworth Staging of Retinoblastoma for the likelihood of High Risk Pathologic Features. Yacoub Yousef, Ibrahim Alnawaiseh, Maysa AlHissaini, Imad Jaradat, Iyad Sultan, Rasha Deebajah, Mustafa Mehyar 39- One RB World Online: A Virtual Retinoblastoma Clinic. Helen Dimaras, Ashwin Mallipatna, Charles Baik, Li Qun He, Michelle Lee, Karolina Frasunkiewicz 40- Intra-arterial chemotherapy for retinoblastoma: first year results from India. Pukhraj Rishi, Vikram Koundanya, Vishvesh Agarwal, Tarun Sharma 41- Ocular Salvage with Vision after Topotecan Based Chemotherapy for the Treatment of Bilateral Intraocular Retinoblastoma. Rachel Brennan, Shenghua Mao, Ibrahim Qaddoumi, Carlos Rodriguez-Galindo, Matthew W. Wilson 42- Cytopathology of Aqueous Humor and Ocular Washings Following Intra-vitreal Injection of Melphalan for Retinoblastoma. Patricia Chevez-Barrios, Murali Chintagumpala, Dan Gombos 43- Systemic toxicity of periocular topotecan in the treatment of retinoblastoma. Lindsey Eibeler, Edith Guarini, Jasmine Francis, Brian Marr, Ira Dunkel, David Abramson 44- Focal treatment of retinoblastoma tumors with simultaneous 810nm and 532nm lasers. Payal Shah, Vandhana Surendranath, Supriya Dabir, Ashwin Mallipatna 8

9 TUESDAY JUNE Small Blue Round Cells Tumors after hereditary retinoblastoma: late metastatic relapse or secondary tumor? Filomena Pierri, Paul Freneaux, Hervé Brisse, Catherine Dehainault, isabelle Aerts, Nadege Corradini, Didier Frappaz, Odette Mariani, Kadija Aitrais Gaelle Pierron, Claude Houdayer, François Doz, Franck Bourdeaut 46- Conservative treatment of intraocular bilateral retinoblastoma: a prospective phase II trial for macular or paramacular involvement on both eyes or on the only saved eye. Ida Russo, Christine Levy-Gabriel, Livia Lumbroso - Le Rouic, Laurence Desjardins, Nathalie Cassoux,Axelle Dupont François Doz, Alexia Savignoni, Isabelle Aerts 47- Retinoblastoma in a Pediatric Oncology Reference Center in Southern Brazil. Simone Selistre, Marcelo Krieger Maestri, Patricia Santos-Silva, Lavinia Faccini, Luciano Guimarães, Juliana Giacomazzi, Mario Evangelista Jr, Patricia Prolla 48- Intravenous versus intra-arterial chemotherapy as primary treatment for Retinoblastoma. Sara Lally, Adel Alset, Emil Anthony Say, Carol Shields 49- Pre-diagnostic Intervals in Retinoblastoma. Clarissa Mattosinho, Nathalia Grigorovski, Evandro Lucena, Sima Ferman, Arlindo Portes 50- Retinoblastoma network in China. Junyang Zhao 51- Case study of vision outcomes in children with posterior pole retinoblastoma treated with prophylactic occlusion therapy. John Ainsworth, Helen Jenkinson, Manoj Parulekar, Sarah Turner, Carol Hitchcott, Maureen McCalla 52- Standard operative procedures in retinoblastoma management in SickKids. Brenda Gallie, Jacqueline Cheung, Sameh Elsayed Soliman, Helen Dimaras 14h30-15h30 Room: Amphitheatre Berlioz Free Papers Chairs: David Abramson, Livia Lumbroso - Le Rouic 14h30 Complications of Intra-arterial Chemotherapy (Chemosurgery) for Retinoblastoma. Pierre Gobin, Jasmine Francis, Brian Marr, Scott Brodie, David Abramson 14h40 Ophthalmic Artery Chemosurgery For Advanced Retinoblastoma Eyes. Armida Fabius, Pierre Gobin, Jasmine Francis, Brian Marr, Ira Dunkel, Scott Brodie, Anna Escuder, David Abramson 14h50 The Addition of Topotecan to Melphalan in the Treatment of Retinoblastoma with Intra-arterial Chemotherapy: Results and Comparison to Melphalan Alone. Andrew Stacey, Theodora Hadjistilianou, Sonia De Francesco 15h00 Rescue intra-arterial chemotherapy following retinoblastoma recurrence after initial intra-arterial chemotherapy. Carol Shields, Pascal Jabbour, Emil Anthony Say, Renelle Pointdujour-Lim, Jerry A. Shields 15h10 Long-term effects of intra-arterial chemotherapy (IAC) on the globe growth in unilateral retinoblastoma patients. Theodora Hadjistilianou, Meliss Bori, Paolo Galluzzi 15h20 Intra-arterial chemotherapy for the management of retinoblastoma: experience at Instituto Nacional de Cancer. Clarissa Mattosinho, Nathalia Grigorovski, Evandro Lucena, Ilana Najman, Ana Carolina Stepanski, Larissa Uemoto, Henrique Salas, Hugo Gouveia, Paulo Faria, Sima Ferman 14h30-15h30 Room: Molière Free Papers - Parallel session Chairs: Pierre Bey, Guillermo Chantada, Swathi Kaliki 14h30 Retinoblastoma in sub-saharan Africa: a programm to develop early diagnosis, treatments and rehabilitation & presentation of the movie for early diagnosis of retinoblastoma in Mali. Fatoumata Sylla, Pierre Bey, Boubacar Togo, Traore B Cheick,François Doz, M Hamed Harif, Laurence Desjardins, Fousseyni Traore 14h40 Treatment of unilateral retinoblastoma. Preliminary results of a multicentric prospective study of GALOP (Grupo de America Latina de Oncologia Pediatrica). Guillermo Chantada, Veronica Perez, Guadalupe Rey, Andreu Parareda, Katherine Kopp, Agustin Dabezies, Gustavo Dufort, Martha Zelter, Juan Pablo Lopez, Marcelo Urbieta, Jaume Català-Mora, Diego Ossandon, Fandino Adriana, J. Oscar Croxatto, María de Davila 14h50 Advanced intraocular retinoblastoma treated by primary enucleation in 913 eyes: Outcomes from a developing country versus a developed country. Swathi Kaliki, Carol Shields, Dilip Mishra, Ralph Eagle, Jerry A. Shields 15h00 Treatment abandonment in patients with retinoblastoma in north India. Usha Singh, Anish Bhargav Deepak Bansal Zoramthara Zadeng, Vaneet Singh 15h10 Intraocular tumors in Thailand: review of diagnosis and treatment in 241 patients. Duangnate Rojanaporn, Tharikarn Sujirakul, Sirintara Pongpech, Daranee Pririyasang, Suradej Hongeng 15h20 Time interval to tumour detection in familial retinoblastoma patients: a retrospective study. Lucy Njambi, Helen Dimaras, Brenda Gallie, Kahaki Kimani 15h30 Clinical Outcomes After Primary Enucleation for Retinoblastoma and the Role of Adjuvant Therapy. Chawla Bhavna, Ashutosh Singh, Rachna Seth, Seema Sen, Rajvardhan Azad, Sushmita Pathy, Mani Kalaivani, Seema Kashyap, Supriyo Ghose 15h40 Clinical and pathological grading of Retinoblastoma cases that enucleated after Neoadjuvant chemotherapy. Adel Alei ElDin, Alaa Elhadad, Hala Taha, Hosam Elzomor, Radwa Nour 15h50 How to cure retinoblastoma: a programm for early diagnosis and treatment of retinoblastoma in Mali. Fousseyni Traore, Fatoumata Sylla, Cheick Boudagari Traore, Laurence Desjardins, Pierre Bey, Boubacar Togo 9

10 TUESDAY JUNE 16 15h30 Coffee break and visit of the Exhibition 16h00-16h30 Room: Amphitheatre Berlioz Invited Speaker Linn Murphree Stallard lecture: Retinoblastoma management in h18 Combined versus single agent Intravitreal Chemotherapy for Refractory or Recurrent Vitreous Seeding from Retinoblastoma. Fariba Ghassemi, Alireza Khodabande, Siamak Sabour 18h21 Discussion 18h30-19h30 Room: Amphitheatre Berlioz 16h30-17h30 Room: Amphitheatre Berlioz Controversy of the day Retinoblastoma: iac versus iv chemotherapy Moderator: Francis Munier Guillermo Chantada, Murali Chintagumpala, Carol Shields, David Abramson, Mandeep Sagoo, Doris Hadjistilianou, Brenda Gallie 17h30-18h30 Room: Amphitheatre Berlioz Free Papers Chairs: Francis Munier, M. Aschwin Reddy 18h00 17h30 Pharmacokinetics of melphalan after intra-vitreal administration in rabbits. Paula Schaiquevich, Emiliano Buitrago, Ursula Winter, Guillermo Chantada 17h40 Topotecan Fluorescence; Uses for Retinoblastoma. David Abramson, Brian Marr, Paula Schaiquevich, Micahel Kellick, Jasmine Francis 17h50 The Classification of Vitreous Seeds in Retinoblastoma and Response to Intravitreal Melphalan. Jasmine Francis, David Abramson, Marie-Claire Gaillard, Brian Marr, Maja Beck-Popovic, Francis Munier Rapid Fire Session (3 per presentation) 18h00 Intra vitreous melphalan simultaneous with the focal therapy increases the regression of resistant recurrent multiple retinoblastoma. Andrey Yarovoy, Tatiana Ushakova, Vladimir Polyakov, Olga Krivovyaz, Olga Gorovtsova 18h03 Intravitreal chemotherapy with melphalan for recurrent or refractory vitreous disease in retinoblastoma after systemic and/or intra-arterial chemotherapy. Luiz Teixeira, Carla R D Macedo, Priscilla L B J Meirelles, Camila Hiromi Hashimot, Renato Melaragno, Juliana F Souza, Ludmila Martins, Juliana Soares, Sidinei Epelman 18h06 Treatment of vitreous seeding in retinoblastoma with a short course of 3 weekly intravitreal melphalan injections. Jonathan Kim, Jesse Berry, A. Linn Murphree, Thomas Lee, Rima Jubran 18h09 Combination IAC-IVC for Recurrent Retinoblastoma After Failed Systemic Chemotherapy. Amy Schefler, Maru Bretana, Eric Kegley, Mark Dannenbaum 18h12 Intravitreal chemotherapy for recurrent or refractory vitreous seeds in eyes with retinoblastoma. Pukhraj Rishi, Tarun Sharma, Vishvesh Agarwal 18h15 Intravitreal Topotecan in the Management of Refractory Vitreous Seeds in Retinoblastoma. Raksha Rao, Vishal Sharma, Vijay Anand P Reddy, Santosh Honavar 10 Case Report Session Chairs: Tero Kivela, Brenda Gallie 18h30 Anterior white orbital mass following enucleation for retinoblastoma. Brenda Gallie, Sameh Elsayed Soliman, Elise Heon, Furqan Shaikh, Helen Chan 18h34 Diffuse Intrinsic Pontine Glioma in an RB patient: Why don t we hear more of this? Katherine Paton 18h38 Clinically Undetectable Retro-laminar Retinoblastoma in an Eye Treated with Intravenous and Intra-arterial Chemotherapy. Patricia Chevez-Barrios, Murali Chintagumpala, Nidale Tarek, Dan Gombos 18h42 Endophtalmitis in retinoblastoma: A misdiagnosed case. Mostafa ElManhaly, Sameh Elsayed Soliman, Shady Fadel 18h46 Extraocular retinoblastoma in a male young-adult patient misdiagnosed as Coats disease. Luiz Teixeira, Carla R D Macedo, Camila Hiromi Hashimot, Paulo G Manso, Alcania P Reis, Vivian S. Tostes, Maria T. S. Alves 18h50 Late onset tumor relapse following intra-arterial chemotherapy for retinoblastoma. Dan Gombos, Cynthia Herzog, Nidale Tarek, Murali Chintagumpala, Patricia Chevez-Barrios 18h54 Successful Management of Medulloepithelioma by Systemic and Intravitreal Chemotherapy. Santosh Honavar, Vishal Sharma, Raksha Rao, Kaustubh Mulay, Vijay Anand P. Reddy 18h58 Vitreoretinal neovascular membranes in retinoblastoma. Gregor Willerding 19h02 Retinoblastoma with vitreous seeding treated by vitrectomy after chemotherapy. Junyang Zhao 19h06 Pathologic TNM staging. What is missing? Sameh Elsayed Soliman, Brenda Gallie, Helen Chan, William Halliday 19h10 An infant with persistent fetal vasculature, focal lissencephaly and seizures: a variant of Walker- Warburg syndrome? Aschwin Reddy, Judith Kingston, Mandeep Sagoo 19h14 Optic disc tumor. Hassan Aziz, Arun Singh 19h18 Orbital tumor recurrence following aggressive laser treatment of a macular tumor. Jonathan Kim, Jesse Berry, Rima Jubran, A. Linn Murphree, Thomas Lee 19h22 Trilateral Retinoblastoma before Birth. David Abramson, Ira Dunkel, Brian Marr, Jasmine Francis 19h26 Successful conservative treatment of massive choroidal relapse in 2 retinoblastoma patients. Christina Stathopoulos, Marie-Claire Gaillard, Stefano Binaghi, Philippe Maeder, Maja Beck-Popovic, Francis Munier 19h30-20h30 Welcome Cocktail in the Congress Venue

11 08h00-10h00 Room: Amphitheatre Berlioz Uveal Melanoma Free Papers Chairs: Norbert Bornfeld, Leonidas Zografos, Ranaa Al Jamal 8h00 Clinical characteristics, treatment and survival in a series of 500 patients with Uveal melanoma in China. Liu Yueming 8h10 Results of conservative treatment of melanomas in Argentina: 11 years experience. Arturo Irarrazaval, Pablo Cazon 8h20 Outcomes of proton beam radiotherapy for larger, non-peripapillary choroidal and ciliary body melanoma at the BC Cancer Agency. Katherine Paton, Britta Weber, Roy Ma, Tom Pickles 8h30 Regression mode of choroidal melanomas presenting a giant RPE rupture after proton therapy and treatment with adjuvant intra-vitreal cortico-therapy. Leonidas Zografos, Ann Schalenbourg 8h40 Local recurrence after proton beam therapy in uveal melanoma: Risk factors, retreatment approaches and outcome. Ira Seibel 8h50 Superior longterm visual outcome using an optic nerve sparing proton beam therapy in posterior uveal melanoma. Antonia Joussen 9h00 Cerenkov Luminescence Imaging: A new technique for the assessment of radioactive plaque position in brachytherapy of uveal melanoma. Joergen Krohn, Johan Axelsson 9h10 New imaging techniques for uveal melanomas. Gena Damento, Jose Pulido, Kelly Koeller, Diva Salomao 9h20 Evaluation of the MedEyeTrac system and MR image fusion for the follow-up of choroidal melanomas after radiotherapy. Werner Wackernagel, Lisa Tarmann, Peter Winkler, Mathias Ruether, Rainer Flitsch, David Ferstl, Thomas Konrad, Carmen Döller, Ulrike Wiesspeiner, Christian Amon, Thomas Hüpf, Gerald Langmann, Karin S. Kapp 9h30 Advanced Ocular Oncology Management: MIVS for Tumor Ablation and Targeted Genomic Therapy. Timothy Murray 9h40 Observation in small uveal melanoma in a Spanish population. Maria Saornil, Ciro Garcia-Alvarez, Maria Fe Muñoz, Francisco Lopez-Lara, Ana Almaraz, Patricia Diezhandino, Frutos-Baraja Jesus 9h50 Fine Needle Aspiration Biopsy in Small Pigment Choroidal Tumors (Less 3 mm). David Pelayes, Arun Singh, Jorge O. Zarate, Anibal Martin Folgar 08h00-10h00 Room: Molière Uveal Melanoma Free Papers - Parallel Session Chairs: Nathalie Cassoux, Shahar Frenkel, Bill Harbour 8h00 itraq quantitative proteomics reveals that p53 signal transduction and related protein phosphorylation may regulate the development of uveal melanoma. Xiaolin Xu, Yingzhi Wang 8h10 Ocular Surface Temperature in Uveal Tumors. Giulia Pieretti, Cinzia Mazzini, Sara Matteoli, Andrea Sodi, Stanislao Rizzo WEDNESDAY JUNE h20 MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1. Yang Li 8h30 DJ-1 and PMEL/GP-100 as potential circulating biomarkers in uveal melanoma. Maria Pardo, Manuel Bande, Maria Santiago Varela, Francisco Ruiz-Oliva, Maria Gil, Carmela Capeans, Maria José Blanco, Antonio Piñeiro-Ces 8h40 Serum Adiponectin, Insulin Resistance and Uveal Melanoma: Clinicopathological Correlations. Hayyam Kiratli, Duygu Gülmez Sevim 8h50 Uveal Melanoma: An Analysis of Potential Prognostic Cellular Features. Charles Biscotti, Fatima Hamadeh, Carlos Medina, Arun Singh 9h00 Angiotropism in Uveal Melanoma: Frequency and Effects of Sampling in 90 Cases. Raymond Barnhill, Claire Lugassy, Aude Battistella, Marc-Henri Stern, Andre Nicolas, Sergio Roman-Roman, Olivier Lantz, Sophie Piperno-Neumann, Marie Schoumacher, Julia Ratour, Anne Vincent-Salomon, Christine Levy-Gabriel, Laurence Desjardins, Nathalie Cassoux 10h00 Coffee break and visit of the Exhibition 10h30-11h20 Room: Amphitheatre Berlioz Round Table Discussion Management of small melanocytic tumors Moderator: Carol Shields Tero Kivela, Paul Finger, Stefan Seregard, Leonidas Zografos, Shahar Frenkel, Timothy Murray, Kan Gunduz 11h20-12h30 Room: Amphitheatre Berlioz Free Papers Chairs: Ivana Kim, Martina Angi, Stefan Seregard 11h20 Intraocular medulloepithelioma: New observations on clinical features, pathology and genetics. Jerry Shields, Swathi Kaliki, Ralph Eagle, Carol Shields 11h30 Long-term anti-vegf induced suppression of radiation maculopathy and optic neuropathy. Ekaterina Semenova, Kimberly J. Chin, Paul Finger 11h40 Ranibizumab in Combination with Proton Beam Irradiation for Choroidal Melanoma: Interim Results. Ivana Kim, Anne Lane, Evangelos Gragoudas 11h50 Role of intravitreal bevacizumab at 4-month intervals after plaque radiotherapy of large ( 8 mm thickness) posterior uveal melanoma: Consecutive analysis of 276 cases. Murat Hasanreisoglu, Carol Shields, Chloe Khoo, Emil Anthony Say, Arman Mashayekhi, Jerry A. Shields 12h00 Intravitreal bevacizumab for macular edema secondary to plaque radiotherapy for uveal melanoma. Monica Asencio-Duran, Eva Corredoira-Silva, Carlos Huerga Cabrerizo, Isabel Rodriguez Rodriguez, Beatriz Manzano Muñoz, Jesus Garcia-Martinez 12h10 Endoresection of posterior uveal melanomas to control vasculopathy secondary to radiation treatment. Zelia Correa, James Augsburger 12h20 Endoresection of uveal melanoma. Norbert Bornfeld

12 WEDNESDAY JUNE 17 12h30 Lunch (Lunch Boxes) 13h00-14h00 Posters Session Room: Hall Menand Posters 55 to Iris melanoma: 15 years experience of the Use of ruthenium plaques. Umiya Agraval, Viskas Chadha, Paul Cauchi, Ewan Kemp 56- Plaque brachytherapy for uveal melanoma: a vision prognostication model II. Hassan Aziz, James Bena, Arun Singh, Allan Wilkinson, Nakul Singh 57- Secondary enucleation for uveal melanoma: a 7 year retrospective analysis. Ido Didi Fabian, Mandeep Sagoo, Amit Arora, Oren Tomkins-Netzer, Victoria Cohen 58- Iodine -125 brachytherapy for large choroidal melanomas: Benefit of vitrectomy and silicone oil on visual acuity. Colin McCannel, Mitchell Kamrava, Jeffrey Demanes, Robert Almanzor, Melissa Chun, Tara McCannel, James Lamb 59- Stratification of metastatic risk of ciliary body melanoma according to UBM assessment. Hatem Krema, Priya Durairaj, Filiberto Altomare, Brenda Gallie, Charles Pavlin 60- Uveal melanoma reccurrence pattern after episcleral brachytherapy. Ciro Garcia-Alvarez, Marai Saornil, Maria Fe Munoz, Francisco Lopez-Lara, Frutos-Baraja Jesus, Ana Almaraz, Patricia Diezhandino 61- Multivariate modeling of regression of uveal melanoma after brachytherapy. Tero Kivela, Rashid Mohammed, Jorma Heikkonen 62- The assessment of scleral and apex dose and the ocular outcome following ruthenium brachytherapy of uveal melanoma. Iwona Rospond-Kubiak, Marta Wrobleska-Zierhoffer, Hanna Twardosz-Pawlik, Jaroslaw Kociecki 63- Uveal melanoma cell lines and the primary tumors from which they are derived: comparison of their characteristics. Frédéric Mouriaux, Solange Landreville, Karine Zaniolo, Marjorie Bergeron, Mohib Morcos, Sylvain Guérin 64- Re Irradiation with stereotactic Radiotherapy as an alternative to enucleation for recurrent choroidal melanoma post plaque brachytherapy: preliminary results. Priya Durairaj, Partricia Daly, Mostafa Heydarian, Akbar Beiki-Ardanaki, Rand Simpson, Filiberto Altomare, Normand J Laperriere, Hatem Krema 65- Intraocular tumors diagnosed after evisceration. Stephanie Lemaitre, Nathalie Cassoux, Laurence Desjardins, Mathieu Zmuda, PierreVincent Jacomet, Olivier Galatoire, Remi Dendale, Livia Lumbroso - Le Rouic, Christine Levy-Gabriel 66- Comprehensive management of uveal melanoma patients in the clinic: Core components in a Tertiary Referral center. Peter Hovland 67- Melanoma after melanoma. Noel Horgan 68- Presentation of posteriorly-located, medium-sized choroiodal melanoma with extraocular extension in a 42-year-old Asian Indian lady. Pukhraj Rishi, Tarun Sharma, Jyotirmay Biswas, Subramanian Krishnakumar, Vikas Khetan 69- Regression of uveal metastases following treatment with PARP-inhibitor in a patient with germline BRCA mutation and advanced breast cancer. Lona Jawaheer, Lisa Bashford, Paul Cauchi Bilateral uveal melanoma: a case report. Federica Genovesi Ebert, Maria Grazia Fabrini Federica Cresti, Agostino Cristaudo, Emanuele Di Bartolo 71- Toric Surgical Marker for Intraoperative Plaque Localization to Treat Choroidal Melanoma: a New Surgical Technique for the University of Southern California Eye Physics Plaque. Jesse Berry, Jonathan Kim 72- International Survey of Surveillance Practices for Uveal Melanoma. Jasmine Francis, Richard Carvajal, David Abramson, Tero Kivela 73- Partial lamellar sclerouvectomy of ciliary body tumors in Japanese. Takashi Fujishiro, Takayoshi Kojima 74- Uveal Melanoma Regression After Brachytherapy: Relationship with Monosomy Chromosome 3. Hassan Aziz, Sachin Salvi, Nakul Singh, Suhail Dar, Brandy Hayden, Arun Singh 75- Results of Ruthenium- plaque Brachytherapy in Case of Choroidal Melanoma. Luise Grajewski, Christiane Kneifel, Ilja Ciernik, Fatemeh Ebrahimi, Lothar Krause 76- Expression and molecular mechanism of mir-21 in uveal melanoma. Wenbin Wei, Yingzhi Wang, Xiaolin Xu 77- Assessing the utility of the Scottish Cancer Register in the research of Uveal Melanoma. Alasdair Simpson, Paul Cauchi, David Morrison, William Sloan 78- Stereotactic radiosurgery for local recurrence of uveal melanoma after plaque brachytherapy. Shahar Frenkel, Atara Cohen, Hadas Rosenne, Mark Wygoda, Yigal Shoshann, Jacob Pe er 79- Comparison of Maximal Basal Dimensions Measured by Wide-Angle Digital Fundus Camera, Fundus Camera, Echography and Clinical Examination in Choroidal Tumors. Hakan Demirci, Joshua Grant, Andrew Stacey, Tanya McClendon, Bernadete Ayres 80- Endoresection after neoadjuvant ruthenium plaque irradiation of posterior uveal melanoma. Gregor Willerding 81- Next Generation Genetic Sequencing of Uveal Melanoma. Armin Afshar, Bertil Damato, Jay Stewart, Boris Bastian, Kirk Jones 82- Spontaneous Regression of Choroidal Melanomas. Takayoshi Kojima, Takashi Fujishiro 83- Rates of Sample Acquisition in Uveal Melanoma Fine Needle Aspiration Biopsies Using Transscleral and Transvitreal Techniques. Amy Schefler, Patricia Chevez-Barrios, Maru Bretana, Bin Teh, Yuval Raizen 84- Prognostic Significance of Gene Expression Profile Class and Largest Basal Diameter of Posterior Uveal Melanomas. Zelia Correa, James Augsburger 85- Lower toxicity and improved outcomes using Ruthenium-106 versus Iodine-125 brachytherapy for uveal melanoma: The MD Anderson Experience. Dan Gombos, Beth Beadle 86- Early subclinical macular edema in eyes with uveal melanoma: Association with future cystoid macular edema. Arman Mashayekhi, Etienne Schonbach, Carol Shields, Jerry A. Shields 87- Keys impacts on health related quality of life for patients undergoing treatment for uveal melanoma. E Weis, RT Crump, B KOPP 88- Identification and proteomic analysis of exosomes derived from human uveal melanoma cell cultures. Manuel Bande, MARIA SANTIAGO VARELA, Maria Jose Blanco-Teijeiro, Carmela Capeans, Francisco Ruiz-Oliva, Antonio Piñeiro-Ces, Maria Pardo

13 89- Endoresection of choroidal melanoma and its combining with radiotherapy: 3-years experience. Andrey Yarovoy, Ilya Gorshkov, Olesya Golubeva, Anna Shatskikh 90- Silencing of PARK7/DJ-1 gene by sirna inhibits uveal melanoma cell proliferation and migration. Maria Santiago Varela, Manuel Bande, Diego Perez Sotelo, Maria Jose Blanco-Teijeiro, Carmela Capeans, Francisco Ruiz-Oliva, Antonio Piñeiro-Ces, Maria Pardo 91- Uveal Melanoma is Associated with an Increased Risk of Cutaneous Melanoma and Renal Cell Carcinoma. Sapna Patel, Dan Gombos, Sanjay Shete, Lauren Haydu, Dae Kim 92- Choroidal melanoma MIA expression is associated with tumour infiltrating macrophages. Svetlana Cherepanoff 93- Transillumination of Uveal Melanoma: A novel use of the Nasoendoscope. Thomas Fearnley, Sachin Salvi 94- Clinical and anatomopathological features of enucleated eyes in La Paz universitary hospital (Madrid, Spain) during time period. Amanda García, Monica Asencio-Duran, Ruiz Bravo Burguillos Elena, Cidad Betegón Pino 95- Associated neoplasia in uveal melanoma. Jeremie Villaret, Stephanie lemaitre, Nathalie Cassoux, Christine Levy-Gabriel, Livia Lumbroso-Le Rouic, Corine Plancher, Alexia Savignoni, Laurence Desjardins 96- A lesion in the cavernous sinus and a melanoma in the eye. Nils Andreas Eide, Monica Sneve, Thomas Pedersen Baerland, Kari Dolven Jacobsen, Øystein Garred, Marta Daniela Switlyk 97- Absorbed dose distributions obtained from inhomogeneous Ru-106 eye plaques: discrepancies with the model used for treatment planning. Wolfgang Sauerwein, Francisco Zaragoza, Marion Eichmann, Dirk Flühs, Lorenzo Brualla 98- Eleven Finnish families with familial choroidal melanoma. Tero Kivela, Rosi Wilska, Joni Turunen, Salla Markkinen, Sinikka Lindh, Anna-Elina Lehesjoki 99- Tumor Cells Enhance Visiblity of Zonular Fibers during Macroscopic Examination of Enucleated Eyes. Ralph Eagle, Jerry Shields, Carol Shields 100- IgG4-related ophthalmic disease mimicking intraocular tumor: report of one case. Hiroshi Goto, Ueda Shunichiro 101- The Impact of Thyroid Hormone Levels on Survival in a Murine B16F10 Model for Ocular Melanoma. Ido Didi Fabian, Mordechai Rosner, Ina Fabian, Vicktoria Vishnevskia-dai, Ofira Zloto, Elena Shinderman Maman, Keren Cohen, Martin Elis, Aleck Hercbergs, Paul Davis, Ashur-Fabian Osnat 14h00-14h30 Room: Amphitheatre Berlioz Words from our Sponsors R&D Perspectives and Innovation Clarity Medical Systems Eckert & Ziegler (Bebig GmbH) FCI Laboratoires Théa Quantel Medical Santen WEDNESDAY JUNE h30-15h30 Room: Amphitheatre Berlioz Free Papers Chairs: Jerry Shields, Jacob Pe er, Edoardo Midena 14h30 Photodynamic therapy for amelanotic uveal melanoma with incomplete response to brachytherapy. Monica Maria Pagliara, Maria Antonietta Blasi, Andrea Scupola, Carmela G Caputo, Angela Lanza, Emilio Balestrazzi 14h40 Peripheral retinal perfusion status correlates with radiation retinopathy following I-125 brachytherapy for uveal melanoma. Prithvi Mruthyunjaya, Sumit Sharma, Paula Pecan 14h50 Survival in a Large Cohort of Patients with Metastasis from Uveal Melanoma. Evangelos Gragoudas, Ivana Kim, Anne Lane 15h00 Staging of uveal melanoma: Comparison of whole body (18) fluorodeoxyglucose (FDG) positron emission tomogra phy computed tomography (PET/ CT) and abdominal ultrasound. Joanna DaCosta, Efthymia Pavlidou, Amit Arora, Elizabeth Somerville, Mandeep Sagoo, Peter Szlosarek, Victoria Cohen 15h10 Sunitinib as an adjuvant treatment for high-risk primary uveal melanoma patients. Takami Sato, Matias Valsecchi, Marlana Orloff, Carol Shields, Jerry Shields, Michael Mastrangelo 15h20 A novel combinatorial treatment option for metastatic uveal melanoma. Shahar Frenkel, Dudi Shneor, Jacob Pe er, Alik Honigman 15h30 Coffee break and visit of the Exhibition 16h00-16h30 Room: Amphitheatre Berlioz Invited Speaker Sophie Piperno-Neumann Recent advances in the systemic treatment of uveal melanoma 16h30-17h30 Room: Amphitheatre Berlioz Free Papers Chairs: Maria Antonetta Blasi, Katherine Paton, Liu Yueming 16h30 Optical Coherence Tomography Angiography (OCT-A) for Evaluation of Retinal Vasculature in Patients Treated with Brachytherapy for Uveal Melanoma. Alison Skalet, Yali Jia, Simon Gao, Liang Lu, Charles R. Thomas, David Wilson, Arthur Hung, David Huang 16h40 Optical coherence tomography angiography analysis of foveal capillary plexus after Iodine-125 plaque radiotherapy of posterior uveal melanoma. Emil Anthony Say, Wasim Samara, Chloe Khoo, Arman Mashayekhi, Jerry A. Shields, Carol Shields 16h50 Swept-source optical coherence tomography imaging of choroidal tumors. Jose M. Caminal, Alejandro Filloy, Sara Jordan, Jaume Catala, Lluis Arias, Marc Rubio, Estefania Cobos, Pere Garcia-Bru 17h00 Anatomic features of choroidal naevi and choroidal hemangiomas: Swept-source optical coherence tomography vs Enhanced depth imaging tomography. A pilot study. Vasilios Papastefanou, Clara Vázquez-Alfageme, Stamatia-Tina Xirou, Simona Degli-Esposti, Praveen Patel, Mandeep Sagoo

14 WEDNESDAY JUNE 17 17h10 En Face Oct Of Choroidal Tumors. Cinzia Mazzini, Daniela Bacherini, Andrea Giorni, Giulia Pieretti, Stanislao Rizzo 17h20 Radiation Maculopathy and Local Inflammatory Biomarkers: an in vivo Spectral Domain OCT Study. Edoardo Midena, Giulia Midena, Luisa Frizziero, Stela Vujosevic, Elisabetta Pilotto, Raffaele Parrozzani 17h30-18h30 Room: Amphitheatre Berlioz Case Report Session Chairs: Jerry Shields, Niklos Bechrakis 17h30 Malignant transformation of ciliochoroidal melanocytoma in an only eye after 42 years of stable review in the London Ocular Oncology Service. Joanna DaCosta, Gordon Hay, John Hungerford, Victoria Cohen 17h34 Management of a choroidal melanoma with intraocular dissemination. J. William Harbour, Amir Mohsenin, Jorge Fortun 17h38 Primary uveal melanoma treated with systemic immunotherapy. Sapna Patel, Elizabeth Reinhardt, Andrew Whyte, Natalie McQuail, Dae Kim, Dan Gombos 17h42 Orbital Recurrence of Choroidal Melanoma presumed secondary to Open flap transcleral biopsy. Thomas Fearnley, Sachin Salvi, Hardeep Mudhar 17h46 Diagnostic challenge of a not so amelanotic choroidal tumor. Zelia Correa, James Augsburger 17h50 Congenital Uveal Melanoma. Arun Singh, Hassan Abdul Aziz, Charles Biscotti, Lynn Schoenfield 17h54 Malignant Transformation of a Choroidal Naevus in an Eye Treated for Choroidal Melanoma. Ido Didi Fabian, Amit Arora, Victoria Cohen 17h58 A Pigmentary Abnormality of the Fundus. Carol Shields 18h02 Multiple Melanocytic Messes. Amy Schefler, Maru Bretana, Bin Teh, Patricia Chevez-Barrios 18h06 A suspected choroidal melanoma with extrascleral extension in a pregnant woman. Vasilios Papastefanou, Ido Didi Fabian, Caroline Thaung, Mandeep Sagoo 18h10 Two rare paediatric intraocular tumours in one family. Mandeep Sagoo, Lamis Alharbi, Sepideh Amin, Judith Kingston, Tanzina Chowdhury, Elisabeth Rosser, M. Aschwin Reddy 18h14 Plaque Brachytherapy in a Large Ciliochoroidal Melanoma: Saving the Only Eye. Raksha Rao, Santosh Honavar, Vishal Sharma, Kaustubh Mulay, Vijay Anand P. Reddy 18h18 Enlarging intra-ocular tumour during pregnancy. Victoria Cohen, Alenka Lavric, John Hungerford 18h22 Single Cell Analyses of Uveal Melanoma reveals Intra-tumoral Heterogeneity that correlates with Prognosis. Arupa Ganguly, Juliana Purrazzella, Jennifer Richards-Yutz, Carol Shields 20h30-22h00 Dining Cocktail in Paris Hotel de Ville THURSDAY JUNE 18 08h00-10h00 & 10h30-10h40 Room: Amphitheatre Berlioz Free Papers Chairs: Bertil Damato, Martine Jager, Sarah Coupland 8h00 Inferring an evolutionary tree of uveal melanoma from genomic copy number aberrations. Nakul Singh, Arun Singh, Winston Hide 8h10 Comparison of Gene Expression Profiling and Chromosome 3 Analysis by Fluorescent In Situ Hybridization and Multiplex Ligation Probe Amplification in Fine Needle Aspiration Biopsy Specimens of Uveal Melanoma. Tara McCannel, Sujit Itty, Elizabeth Richter, Christian Moreno, Colin McCannel 8h20 An independent gene expression assay for prognostication following uveal melanoma. Stefan Seregard, Patrik Radberger, Iulian Oprea, Leonard Girnita 8h30 Uveal melanoma: Prognostic significance of chromosome-3 alterations in tumor samples obtained after enucleation or transvitreal biopsy: a follow-up study. Claudia Metz, Dietmar Lohmann, Stefan Kreis, Norbert Bornfeld, Michael Zeschnigk 8h40 SF3B1 and EIF1AX mutations in uveal melanoma protective or not? Emine Kilic, Anna Koopmans, Serdar Yavuzyigitoglu, Rob Verdijk Jolanda Vaarwater, Dion Paridaens, Annelies de Klein 8h50 A new subset of Class 1 uveal melanomas with distinct clinical and molecular features. J. William Harbour, Matthew Field, Christina Decatur, Kaleigh Kozak, Stefan Kurtenbach 9h00 BAP1 germline mutations in Finnish uveal melanoma patients. Joni Turunen, Salla Markkinen, Sinikka Lindh, Mikko Muona, Virpi Raivio, Martin Täll, Anna-Elina Lehesjoki, Rosi Wilska, Tero Kivela 9h10 Comparison of genetic testing of uveal melanoma biopsies and whole tumour specimen. Heinrich Heimann, Bertil Damato, Helen Kalirai, Vivian Ho, Sarah Coupland 9h20 Genetic Profile Obtained by Minimally Invasive 25-Gauge Transvitreal Retinochoroidal Biopsy Compared with Matched Enucleated Eyes from Patients with Uveal Melanoma. Mette Bagger, Morten Tolstrup Andersen, Mette Klarskov Andersen, Heegaard Steffen, Jens Kiilgaard 14

15 THURSDAY JUNE 18 9h30 FNAB of Uveal Melanoma: Outcomes and Complications. Arun Singh, Carlos Medina, Nakul Singh, Mary Beth Aronow, Hassan Abdul Aziz, Charles Biscotti 9h40 External Validation of the Liverpool Uveal Melanoma Prognosticator Online (LUMPO). Bertil Damato, Sarah DeParis, Wayne Enanoria, Azzam Taktak, Antonio Eleuteri, Sarah Coupland, Heinrich Heimann, Helen Kalirai 9h50 Development and external validation of a prognostic nomogram for metastatic uveal melanoma. Raffaele Parrozzani, Sara Valpione, Pierdavide Perrrini, Luisa Frizziero, Ilaria Testi, Justin Moser, Aaron Mansfield, Svetomir Markovic, Vanna Chiarion Sileni, Edoardo Midena 10h00 Coffee Break and visit of the Exhibition 10h30 Correlation between Loss of BAP1 expression chromosome 3 and inflammation in uveal melanoma. Martine Jager, G. Gezgin, IHG Bronkhorst, T H van Essen, PA van der Velden, GPM Luyten, T van Hall, RM Verdijk, A. de Klein 10h40-11h30 Room: Amphitheatre Berlioz Controversy of the day What type of genetic prognostic testing should be performed in uveal melanoma? Moderator: Bertil Damato Bill Harbour, Sarah Coupland, Gaelle Pierron Martine Jager, Tara MC Cannel, Emine Kilic, Arupa Ganguly 11h30-12h30 Room: Amphitheatre Berlioz ISOO Business Meeting 14h00 Photodynamic Therapy in the Management of Choroidal Metastasis. Hakan Demirci, Devon Ghodasra 14h10 Local versus systemic treatment of choroidal metastases. Maria Antonietta Blasi, Monica Maria Pagliara, Andrea Scupola, Carmela G Caputo, Maria Grazia Sammarco, Emilio Balestrazzi 14h20 Australia and New Zealand Study Of PDT In Choroidal Amelanotic Melanoma (ANZSOPICAM) six-year results. William Campbell, Michael Giblin, Peter Hadden, Tim Isaacs, John McKenzie 14h30 Diagnosis of vitreoretinal lymphoma: the use of cytology, gene rearrangement, and IL-10/IL-6 ratio. Jacob Pe er, Inna Kalickman, Yoav Sherman, Bella Maly, Dina Ben Yehuda, Vivian Barak, Shahar Frenkel 14h40 Upregulation of mirna in primary vitreoretinal lymphoma specimens: A new diagnostic approach? Vinodh Kakkassery, Marc-Ilan Wunderlich, Marc Schargus, Burkhard Dick, Uwe Schlegel, Roland Schroers, Alexander Baraniskin 14h50 Treatment Response and Long Term Survival for Primary Intraocular Lymphoma: The MD Anderson Experience. Dan Gombos, Patricia Chevez-Barrios, Nathan Fowler 15h00 Vitreoretinal lymphoma (VRL) and the Incidence of retinal detachment. Brian Marr, Irena Belinsky, Jasmine Francis, David Abramson 15h nm Yellow Laser Photocoagulation for Coats Disease. G. Baker Hubbard 15h20 Characteristics and outcome of choroidal and ciliary body melanoma among children, a Collaborative Study by the European Ophthalmic Oncology Group. Rana a Al-Jamal, Nathalie Cassoux 15h30 Coffee Break and visit of the Exhibition 12h30 Lunch in Hall Menand 13h30-15h30 Room: Amphitheatre Berlioz Free Papers Chairs: Sonia Callejo, Vicky Cohen, Jerry Shields 13h30 Intraosseous haemangioma, and other selected tumours, treated with selective embolization. RJW DE Keizer 13h40 Verteporfin photodynamic therapy for the treatment of vasoproliferative tumours of the retina. Martina Angi, Rumana Hussain, Fidan Jmor, Bertil Damato, Heinrich Heimann 16h00-16h45 Room: Amphitheatre Berlioz Invited Speaker Marc-Henri Stern Genetic landscape of uveal melanoma And Bita Esmaeli update on uveal melanoma TCGA project 16h45-17h30 Room: Amphitheatre Berlioz Round table Topical therapy for malignant conjunctival tumors Moderator: Jacob Pe er Edoardo Midena, Sara Lally, Bita Esmaeli, A. Schalembourg, Christine Levy 13h50 Ruthenium plaque radiotherapy in the treatment of retinal vasoproliferative tumours. Mandeep Sagoo, Alenka Lavric, Konstantinos Kopsidas, Amit Arora, John Hungerford, Victoria Cohen 15

16 THURSDAY JUNE 18 17h30-18h30 Room: Amphitheatre Berlioz Case Report Session Chairs: Tim Murray, Stefan Seregard 17h30 Comprehensive Review of the BAP1 Tumor Predisposition Syndrome with Report of Two New Cases. Colleen Cebulla, Karan Rai, Robert Pilarski, Frederick Davidorf, Mohamed Abdel-Rahman 17h34 Unusual Uveitis - Can OCT HELP? Karin Loeffler, Martina Herwig 17h38 Bilateral Exudative Retinopathy in a 2 Year-Old. Matthew W. Wilson, Rosa Nguyen, Israel Fernandez-Pineda, Rachel Brennan, Wayne Furman 17h42 Occult intraocular foreign body mimicking an intraocular mass. Eduardo Marback, Roberto Marback, Luciano Fonseca 17h46 Eye Diktyoma, Intracranial teratoma and scalp lipoma. Adel Alei ElDin, Hala Taha, Fayrouz Orensa 17h50 Ciliarybody Medulloepithelioma- an atypical scenario. Fairooz Manjandavida, Santosh Honavar, VijayAnand, P. Reddy, Geeta K Vemuganti 17h54 An exudative amelanotic ciliary body tumor. Helen Li, Debra J. Shetlar, Thomas C, Milton Boniuk 17h58 Epithelial downgrowth masquerading as iris tumor. Lamis Alharbi, Sara Vaz-Pereira, Gabriella De Salvo, Caroline Thaung, Mandeep Sagoo 18h02 Evolving Management of Vitreoretinal Lymphoma. Colin McCannel, Sven De Vos 18h06 Ebstein-Barr virus (EBV)-associated iris leiomyosarcoma in AIDS patients. Duangnate Rojanaporn, Yanin Suwan, Rangsima Aroonroch 18h10 Retinal Metastasis of Leiomyosarcoma: diagnosis and treatment. Peter Hovland 18h14 About to explode: a growing retinal tumor. Prithvi Mruthyunjaya 18h18 BDUMP Case Presentation. Marcelo Krieger Maestri 18h22 Multifocal bilateral amelanotic choroidal lesions. Arman Mashayekhi, Carol Shields, Jerry A. Shields 18h26 Unknown case: solitary circumscribed presumed retinal astrocytic proliferation. Jerry Shields, Carol Shields, Tero Kivela Cours d Oncologie Oculaire (in English & French - en anglais et français) Réservé aux membres de la SFO (sur pré-inscription auprès de la SFO) 9h00-10h20 Room: Molière Session Rétinoblastome et tumeurs intraoculaires rares 9h00 Diagnostic et diagnostic différentiel Livia Lumbroso - Le Rouic 9h20 Stratégies thérapeutiques en 2014 Livia Lumbroso - Le Rouic 9h40 Conseil génétique. Marion Gauthiers Villars 10h00 Tumeurs intraoculaires rares de l enfant Christine Levy 10h20 Pause-café 11h00-12h30 Room: Molière Tumeurs de l adulte - Session 1 11h00 Tumeurs intraoculaires rares de l adulte Jerry Shields 11h30 Ponctions transclérales et transvitréennes Nathalie Cassoux 12h00 Gestion des prélèvements Alexandre Moulin 12h30 Lunch boxes 14h00-16h00 Room: Molière Tumeurs de l adulte - Session 2 14h20 Prise en charge des naevi choroïdiens suspects Carol Shields 14h40 Prise en charge des tumeurs pigmentées de l iris A. Schalembourg 15h00 Traitement du mélanome de l uvée Laurence Desjardins 15h20 Pronostic du mélanome de l uvée. Bertil Damato 15h40 Traitement des complications de l irradiation Tero Kivela 14h00 Diagnostic des tumeurs choroïdiennes Léonidas Zografos 16h00 Pause-café 16h30-18h00 Room: Molière Tumeurs conjonctivales - Session 3 16h30 Revue des tumeurs conjonctivales. Stefan Seregard 16h50 Traitement chirurgical des tumeurs conjonctivales malignes. Nathalie Cassoux 17h00 Les traitements complémentaires de tumeurs conjonctivales malignes. Laurence Desjardins 17h20 Tumeurs conjonctivales et pseudotumeurs - Présentation de cas cliniques. Jerry Shields 18h Fin du cours 20h00-23h00 Dinner Cruise on the Seine River 16

17 FRIDAY JUNE 19 08h00-10h00 Room: Amphitheatre Berlioz Free Papers Chairs: Stefen Heegaard, Rafaele Parrazoni, Maria Saornil 8h10 Prognostic significance of ZEB1 and ZEB2 in Eyelid Sebaceous Gland Carcinoma. Mansi Bhardwaj, Seema Sen, Kunzang Chosdol, Anjana Sharma, Seema, Kashyap, Neelam Pushker, Mandeep S Bajaj, Sameer Bakhshi 8h20 Lesion of the conjunctiva, clinical and histopathological features, therapeutic options and recurrence: retrospective 10 years cohort of 429 patients in a tertiary referral center. Vicktoria Vishnevskia-dai, Igor Minster, Guy Bensimon, Ayelet Priel, Nchum Rosen, Ido Didi Fabian, Mordechai Rosner 8h30 Bilateral Sequential Invasive Squamous Cell Carcinoma of the Conjunctiva. Omar Ozgur, Bradley Thuro, Gagan Dudja, Bita Esmaeli 8h40 Long-term results of proton radiotherapy in advanced malignant melanoma of the conjunctiva. Simone Scholz, Wolfgang Sauerwein, Joel Herault, Henrike Westekemper, Klaus-Peter Steuhl, Klaus Griewank, Juliette Thariat 8h50 Plaque Brachytherapy for Invasive Ocular Surface Neoplasia. Vishal Sharma, Paul Finger, Ekaterina Semenova, Kimberley Chin 9h00 Long-term Outcome of Combined (Perilesional Injection and Topical) Interferon Alpha-2b Therapy in the Management of Ocular Surface Squamous Neoplasia. Samuray Tuncer, Derda Ozer 9h10 Effect of topical interferon alpha-2b eye drop on conjunctival melanoma. Satoru Kase 9h20 Clinical Relevance of Senescence related genes in Ocular Surface Squamous Neoplasia. Sheetal Chauhan, Seema Sen, Anjana Sharma, Seema Kashyap, Shyam Chauhan, Neelam Pushker, Mandeep S Bajaj, M. Vanathi, Radhika Tandon, Namrata Sharma 9h30 Controlling the response to p53 reactivation therapy in conjunctival melanoma through β-arrestins-biased IGF-1R signaling. Leonard Girnita, Ada Girnita, Stefan Seregard 9h40 Conjunctival melanoma is sensitive in vitro to MEK inhibition and dual PI3K/mTOR inhibition. Alexandre Moulin, Donata Rimoldi, Ann Schalenbourg, Leonidas Zografos, Michael Nicolas 9h50 Satellite Metastases in Rapidly Fatal Conjunctival Melanoma: Implications for Angiotropism and Extravascular Migratory Metastasis. Raymond Barnhill, Claire Lugassy, Stephanie Lemaitre, Christine Levy-Gabriel, Laurence Desjardins, Nathalie Cassoux 10h30-12h30 Room: Amphitheatre Berlioz Free Papers Chairs: Michael Giblin, Brian Marr, Christine Levy 10h30 Adjuvant Therapy and Clinical Outcome in Advanced Corneal Epithelial Neoplasia. Murat Tunc 10h40 Surgery reconstruction of ocular surface tumors using fibrin sealant tissue adhesive. Virginia Torres, Aline Paiva 10h50 Malignant lymphoma of the conjunctiva: a multicenter international study. Heegaard Steffen, Peter Rasmussen, Sarah Coupland, Paul Finger, Gerado Graue, Grossniklaus Hans, Santosh Honavar, Penny McKelvie, Kaustubh Mulay, Jan Ulrik Prause, Elisabeth Ralfkiaer, Lene Sjö, Marina Kirkegaard 11h00 Can cryotherapy be a major option for conjunctival MALT lymphoma? Minoru Furuta, Yasuharu Oguchi, Tetsuju Sekiryu 11h10 Gene expression profile of Conjunctival Squamous Cell Carcinoma. Laura Asnaghi, Hind Alkatan, Alka Mahale, Maha Othman, Saeed Alwadani, Hailah Al-Hussain, Sabah Jastaneiah, Wayne Yu, Azza Maktabi, Deepak Edward, Charles Eberhart 11h20 Cyclooxygenase-2 and PPARγ in Eyelid Sebaceous Gland Carcinoma. Perumal Jayaraj, Seema Sen, Dhanaraj PS, Kameshwar Sharma, Mansi Verma, Neelam Pushker, Mandeep S Bajaj 11h30 Neo-adjuvant Chemotherapy in Advanced Eyelid Sebaceous Gland Carcinoma. Fairooz Manjandavida, Santosh Honavar, Vijay Anand P. Reddy 11h40 Nonsurgical Treatment for Locally Advanced Basal Cell Carcinoma of Eyelid and Basal Cell Nevus Syndrome. Bita Esmaeli, Omar Ozgur 11h50 Spontaneous Regression of Sebaceous Carcinoma of the Eyelid and Orbit following Small Incisional Biopsy: Report of 2 Cases. Seymour Brownstein 12h00 Significance Of Estrogen And Progesterone Receptors In Eyelid Sebaceous Gland Carcinoma. Seema Sen, Perumal Jayaraj, Seema Kashyap, Anjana Sharma, Neelam Pushker, Mandeep S. Bajajh 12h10 Ocular Adnexal Follicular Lymphoma: A Multicenter International Study. Peter Rasmussen, Sarah Coupland, Paul Finger, Gerado Graue, Grossniklaus Hans, Santosh Honavar, Penny McKelvie, Kaustubh Mulay, Jan Ulrik Prause, Elisabeth Ralfkiaer, Lene Sjö, Heegaard Steffen 12h20 Ocular adnexal lymphoma in an asian population. Stephanie Young, Shi Wang, Michelle Poon, Stephanie Lang, Shantha Amrith, Gangadhara Sundar 12h30 Lunch Boxes 10h00 Coffee Break and visit of the Exhibition 17

18 FRIDAY JUNE 19 13h30-14h30 Posters Session Room: Hall Menand Posters 103 to Fine needle aspiration of Diagnostically Challenging tumors. Arman Mashayekhi, Adel Alset, Wasim Samara, Chloe Khoo, Carol Shields, Jerry Shields 104- Bevacizumab injections in patients with a choroidal neovascular membrane secondary to choroidal osteoma. Lamis Alharbi, Vasilios papastefanou, Maria Pefkanaki,Richard Andrews, Mandeep Sagoo, Victoria Cohen 105- Rare non retinoblastoma globe filling tumors in childhood. Sabrina Schlueter 106- External Photon beam radiation therapy for diffuse chroroidal hemangiomas in Sturge Weber Syndrome. Remi Dendale, Matthieu Randon, Christine Levy-Gabriel, Marie Eglantine Dujaric, Valentin Calugaru, Livia Lumbroso - Le Rouic, Nathalie Cassoux, Laurence Desjardins, Sofia Zefkili, Corine Plancher 107- Multiple Intraocular Tumors. Tara McCannel 108- Vasoactive proliferative tumor of the retina. Murat Tunc 109- Choroidal Mass as a Presenting Sign of Collecting Duct Carcinoma of the Kidney. Sonal Chaugule, Kaustubh Mulay, Santosh Honavar 110- Choroidal Metastasis from Carcinoma of the tongue. Amit Arora 111- Urothelial carcinoma metastatic to the Retina diagnosed by vitreous biopsy. Ralph Eagle, Tamara Vrabec, Jerry Shields, Carol Shields 112- Choroidal metastasis as initial sign of CUP syndrome a report of two cases. Martin Gryga, Christiane Kneifel, Luise Grajewski, Axel Florschütz, Heike Boye, Jürgen Knolle, Lothar Krause 113- Retinal Metastasis from lung Cancer. Case Report. Carolina Gentile, Carlos Miguel Ortega, J Oscar Croxatto 114- Medulloepithelioma: diagnostic difficulties, clinical behaviour and treatment in four cases. Sonia De Francesco, Theodora Hadjistilianou, Paolo Galluzzi, Paolo Toti, Felice Menicacci, Melissa Borri, Alfonso Cerase 115- Medulloepithelioma of the ciliary body presenting in adulthood: A case report. Samuray Tuncer, Nesimi Buyukbabani, Bercin Tarlan, Sule Ozturk Sari, Bilge Can Meydan 116- Diffuse bilateral ciliary body enlargement and optic nerve head swelling in a lady with previous breast cancer. Fariba Ghassemi 117- Vascular tumors of the iris. They do exist. Jerry Shields, Brad Kligman, Carol Shields 118- Optical coherence tomography (OCT) choroidal surface findings for the differential diagnosis of choroidal tumors. Vicktoria Vishnevskia-dai, Dinah Zur, Shiran Yaacobi, Iris Moroz, Hadas Newman, Ido Didi Fabian, Meira Neudorfer 119- OCT Angiography. A New Tool for Ocular Oncology. Carol Shields, Sandor Ferenczy, Emil Anthony Say, Sara Lally, Arman Mashayekhi, Jerry A. Shields 120- Ciliary Body Melanocytomas: Ultrasonographic Characteristics and Natural Course. Basil Williams, Phillip Tenzel, Marco Gonzalez, J. William Harbour, Jose Antonio Bermudez-Magner 121- Focal laser photocoagulation for symptomatic polypoidal choroidal vasculopathy associated with choroidal nevus. Monica Asencio-Duran, Jesus Garcia-Martinez, Ernesto Sánchez-Jacob Serum Hypercoagulability States in Coats Disease. Fariba Ghassemi, Masoumeh Mohebi, Siamak Sabour, Carol Shields 123- Changes in a case of combined hamartoma of the retina and retinal pigment epithelium indicating growth. Erlend Landsend, Rowan Faber, Nils Eide 124- Classification of sclerochoroidal calcification based on enhanced depth imaging optical coherence tomography Mountain-Like features. Murat Hasanreisoglu, Jarin Saktanasate, Patrick W. Shields, Carol Shields 125- Intravitreal bevacizumab treatment for symptomatic choroidal hemangioma. Anning Chao 126- Spontaneous Regression of Sebaceous Carcinoma of the Eyelid and Orbit following Small Incisional Biopsy: Report of 2 Cases. Seymour Brownstein 127- Management of recurrent prolapsed margins in a semicircular rotation flap of the lower eyelid. Daniel Briscoe 128- Corneal Melanoma. Jill Wells 129- Hemophagocytic lymphohistiocytosis syndrome-pathologic inmune activation may affect the eye too. Raquel Benavides 130- Recurrence of bilateral conjunctival follicular lymphoma after low-dose radiation therapy. Sophie Cotting-Bodmer, Alexandre Moulin, Carl P. Herbort, Nicolas Ketterer, Michael Betz, Alessia Pica, Ann Schalenbourg 131- Focal High Dose Rate Brachytherapy For Conjunctival Tumors. Udi (Ehud) Reich, Gil ad N. Cohen, Sion Koren, David Abramson, Alain Guemnie Tafo 132- Management of reccurent conjunctival melanoma. Vicktoria Vishnevskia-dai, Eran Alon, Ronnie Shapira, Oded Sagiv, Mordechai Rosner 133- Complex combined therapy for conjunctival melanoma. Giulia Pieretti, Marco Puccioni, Luca Liuzzi, Elisabetta Projetto, Vincenza Maio, Stanislao Rizzo 134- Conjunctival melanoma: the Paris experience. Christine Levy-Gabriel, Corine Plancher, Nathalie Cassoux, Xavier Sastre, Livia Lumbroso-Le Rouic, Remi Dendale, Laurence Desjardins 135- Neuroendocrine tumors in lacrimal drainage system. Hideki Tsuji, Megumi kobayashi, Kunihiro Azuma, Kazuyoshi Outomo 136- Steroid therapy for cases with IgG4-related ophthalmic disease. Masayuki Takahira, Shoko Hamaoka Started, Kazuhisa Sugiyama, Mitsuhiro Kawano, Kazunori Yamada 137- A clinicopathological study of IgG4-related ophthalmic disease. Ueda Shunichiro, Hiroshi Goto, Keisuke Kimura, Kazuhiko Umazume, Motoko Shibata 138- Two cases of conjunctival squamous cell carcinoma requiring orbital exenteration. Hiroya Kashiwgai, Tetsuro Onitsuka, Masahiro Nakagawa, Ichiro Ito, Syusuke Yoshikawa, Tomohito Suda, Miwa Komori 139- Using the American Joint Committee on Cancer (AJCC) classification for Ocular Surface Squamous Neoplasia in a referral center in Brazil. Priscilla Ballalai, Ruth Santo, Mario Monteiro 140- Surgical managment of different orbital cavernous hemangiomas. Artur Klett, Juri Ivanov 141- Orbital Metastases from Breast Carcinoma. Sonal Chaugule, Kaustubh Mulay, Vijay Anand P Reddy, Santosh Honavar 142- Orbital Mucocele as a Masquerading Lesion. Murat Tunc

19 FRIDAY JUNE Orbit: An Uncommon Primary Site for Common Tumours. Raksha Rao, Kaustubh Mulay, Vijay Anand P. Reddy, Santosh Honavar 144- Orbital solitary fibrous tumor- a painless mass after dacryocistorhinostomy. Maria Araujo, António Pereira, Tania Borges, Yolanda Maya 145- An eyelid lesion in an 11 year old boy. Sara Lally 146- Orbital reconstruction following exenteration in two cases of intraocular melanoma with extraocular extension. Artur Klett, Reile Rebane 147- Bilateral Epibulbar Masses: Atypical Presentation of a Rare Disease. Mary Beth Aronow 148- Stereotactic Radiosurgery for Periorbital Cutaneous Carcinoma with Perineural Spread into the Orbit. Christopher Barker 149- Navigation system assisted surgical treatment on a patient with extensive orbital neurofibromatosis type 1. Renbing Jia 150- Primary Simple Limbal Epithelial Transplantation at the time of excision of Giant Ocular Surface Squamous Neoplasia. Swathi Kaliki, Virender Sangwan 151- Merkel s tumor of the eyelid. Maria Araujo, António Pereira, Tania Borges, Yolanda Maya 14h30-15h30 Room: Amphitheatre Berlioz Free Papers Chairs: Dan Briscoe, Bita Esmaeli, Livia Lumbroso - Le Rouic 14h30 Defining the Surgical Apex in the Orbit. Daniel Briscoe 14h40 Air sufflated high definition dacryoendoscopy has potential to detect small sized tumor in the lacrimal pathway. Tsugihisa Sasaki, Hideki Tsuji, Tsutomu Sounou, Noriko Saito, Taeko Oota, Kazuhisa Sugiyama 14h50 Granular Cell Tumor of The Orbit: A Clinicopathologic Case Series. Sander Dubovy, Jose E. Velazquez-Vega, Jose Antonio Bermudez-Magner, Maria Paula Fernandez-Jimenez, Mehrdad Nadji, Andrew E. Rosenberg 15h00 Orbital exenteration using eyelid and supraorbital nerve sparing technique. Victoria Cohen, Joanna DaCosta, Tina Xirou, Nicholas Plowman, John Hungerford 15h10 Adenoid Cystic Carcinoma of the Lacrimal Gland: Management and Outcome. Santosh Honavar, Ramesh Murthy, Sima Das, Kaustubh Mulay Geeta, K Vemuganti, Vijay Anand, P Reddy 15h20 Orbital Rhabdomyosarcoma Clinical Profile and Outcome Following Multimodal Management. Sonal Chaugule, Santosh Honavar, Kaustubh Mulay, Vijay Anand P Reddy 15h30 Coffee Break and visit of the Exhibition 16h30-17h30 Room: Amphitheatre Berlioz Case Report Session Chairs: Jacob Pe er, Dan Gombos 16h30 A case of intravascular large B cell lymphoma initially presented as uveitis. Koh-ichi Ohshima 16h34 Intravitreal Bevacizumab in the treatment of neovascular glaucoma associated with metastatic breast cancer. Ekaterina Semenova, Joshua Silverman, Ruth Oratz, Paul Finger 16h38 Epithelioid leiomyosarcoma of iris. David Pelayes, Anibal Martin Folgar, Jorge O. Zarate 16h42 Intralesional Rituximab for Primary Iris Lymphoma. Hakan Demirci, Joshua Grant, Victor Elner 16h46 Mighty Myd88. Jose Pulido, Diva Salomao, David Viswanatha 16h50 Acute visual loss due to choroidal infiltration in Rosai-Dorfman disease. Tim Isaacs 16h54 Small choroidal melanoma revealed by a large extrascleral extension. Stephanie Lemaitre, Nathalie Cassoux, Mathieu Zmuda, Olivier Galatoire, Pierre-Vincent Jacomet, Laurence Desjardins 16h58 A Rapidly Growing Iris Melanocytoma with Pigmentary Glaucoma in a 6 -Year Old Girl. Vishal Sharma, Paul Finger, Paul Sidoti 17h02 Bilateral Primary Adenocarcinoma of the Eyelid and Orbit. Omar Ozgur, Bita Esmaeli 17h06 Intracameral growth of the conjunctival squamous cell carcinoma. Iwona Rospond-Kubiak, Kinga Sosnowska, Jaroslaw Kociecki, Andrzej Marszalek 17h10 Complication after combined treatment with topical Mitomycin C (MMC) and Interferon for Ocular Surface Squamous Neoplasia (OSSN). Priscilla Ballalai, Ruth Santo 17h14 Cases with optic neuropathy caused by IgG4-related orbital mass lesions. Masayuki Takahira, Shoko Hamaoka, Kazuhisa Sugiyama, Daisuke Takemoto 17h18 A rare case of Amelanotic Primary Acquired Melanosis. Udi (Ehud) Reich, Maya Eiger Moscovich, Irit Bahar 17h22 Novel treatment for uveal melanoma of the orbit. Jasmine Francis, Christopher Barker, David Abramson, Paul Chapman, Y Pierre Gobin 17h26 Ectopic Orbital Meningioma. Brian Marr, Irena Belinsky, Ira Dunkel, Jasmine Francis, David Abramson 17h30 Latent Threat Malignant Transformation of Orbital naevus of Ota. David H. Verity, J. Richard, O. Collin, Andrew Dawood, Iain Hutchison 16h00-16h30 Room: Amphitheatre Berlioz Invited Speaker Serge Morax Recent improvement in the management of orbital tumors End of the meeting 19

20 GENERAL INFORMATION Dates and Venue June 16-19, 2015 Palais des Congrès in Issy-les-Moulineaux 25 avenue Victor Cresson Issy-les-Moulineaux - France Metro line 12, stop at Mairie D Issy Registration On line registrations will close on June 11, After this date you will have to register on site. Category On site Member $ 1050 Non member $ 1250 Non member $ 850 Porte de Versailles Palais des Congrès d Issy Gare Montparnasse PARIS Registration to the Ocular Oncology Course on Thursday June 18 Only SFO members can register to this course and need to register before the Congress directly to the SFO (Société Française d Ophtalmologie). Social Programme June 16, h30-20h30 Welcome Reception in the Congress Venue Included in the registration fee Gare de Lyon June 17, h00-22h00 Dining Cocktail at Paris Hotel de Ville Hotel de ville de Paris - 5 rue Lobau Paris Metro line 1, stop at Hotel de Ville. Entrance located at a 5-minute walking distance. M Hôtel de Ville Rue de Rivoli Paris Hôtel de Ville June 18, h00-23h00 Dinner Cruise on the Seine River Port Henri IV Paris Bus transfers will be organized from the Congress venue to the dinner gala boat. Departure at 19h00 from the Congress venue and return at the end of the cruise from 23h00 to the main hotels and Congress venue. Rue Lobau Eglise Saint-Gervais Quai de l Hôtel de Ville Voie Georges Pompidou 20

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