Update in Hematology Oncology Targeted Therapies. Mark Holguin

Size: px
Start display at page:

Download "Update in Hematology Oncology Targeted Therapies. Mark Holguin"

Transcription

1 Update in Hematology Oncology Targeted Therapies Mark Holguin

2 25 years ago Why I chose oncology People How to help people with possibly the most difficult thing they may have to deal with Science Turning the emerging knowledge of the molecular basis of malignancy into effecfve and non- toxic therapy

3 TradiFonal chemotherapy Standard treatment for cancer during the last several decades has been intravenous chemotherapy Targets rapidly dividing cells, malignant and normal Many successes Pediatric acute leukemia TesFcular cancer Decreasing number of new chemotherapy agents being tested and approved

4 Chemotherapy Side Effects

5

6 Targeted therapy Drugs or anfbodies that block the growth and spread of cancer by interfering with specific molecules (targets) involved in cancer growth. Promises treatment specific to malignant cells and avoids toxicity to normal Fssues. Generally categorized as either monoclonal anfbodies or small molecules Monoclonal anfbodies designed to interact with cell surface anfgens Frequently humanized Small molecules are capable of diffusing into cells and act on intracellular targets IdenFfied in large scale screens for interacfng with target

7 Breast Cancer Breast cancer treatment uses surgery, radiafon and chemotherapy to treat and possibly cure early stage breast cancers MetastaFc breast cancer will frequently respond to tradifonal chemotherapy Not curafve treatment Average durafon of response ~6 months

8 First Targeted Therapy First molecular target was the estrogen receptor of breast cancer cells. Tamoxifen Binds to the estrogen receptor and blocks signal transducfon Developed as birth control agent in 1960 s. InvesFgators quickly appreciated its potenfal for treatment of breast cancer

9 Tamoxifen

10 Tamoxifen Oral agent with minimal side effects Hot flashes, risk of blood clot, endometrial cancer In 1970 s showed good response rates in metastafc breast cancer that express estrogen receptors. DuraFon of response beber than with chemotherapy In 1990 s adjuvant therapy given for 5 years reduced recurrence rates of breast cancer ader surgery by ~50%

11 HER2 Breast cancer prognosfc factors ER status, tumor size, stage, grade Expression of Her 2 Her2 (human epidermal growth factor receptor 2) a surface protein that interacts with an unknown ligand acfvates proliferafve signaling pathways Her2 is over expressed on ~30% of breast cancer and confers poor prognosis Overexpression mediated by gene amplificafon TesFng for HER2 expression now standard in breast cancer

12 HercepFn HercepFn (Trastuzumab) Humanized monoclonal anfbody binding to Her2 ToxiciFes primarily infusion reacfons Cardiac toxicity Given as 1-2 hour infusion either weekly or every 3 weeks Treatment of metastafc disease Select cases dramafc responses Usually given along with chemotherapy Adjuvant treatment Reduces recurrence rate by 50% 1 year course

13 Non Hodgkins Lymphoma Divided into aggressive and indolent Aggressive Grow quickly, lethal, potenfally curable ~50% cure rate with CHOP chemotherapy Toxic with hair loss, nausea, myelosuppression Indolent Grow slowly, prolonged survival, not curable Responds well to a variety of chemo CHOP, CVP, BendamusFne

14 Rituximab A monoclonal anfbody targefng CD20 protein that is expressed on surface of B lymphocytes Humanized to prevent immune reacfon ToxiciFes primarily infusion reacfon Decreased normal B cell funcfon well tolerated Unlike HercepFn, no cardiac toxicity

15 Rituximab Treatment of indolent B cell lymphoma Enhances chemotherapy response rates Used alone over half of pafents will respond 4 weekly treatments Can be repeated at relapse Not curafve

16 Rituximab Treatment of aggressive lymphoma Response rates low (15%) used alone Enhances response and survival rates when combined with chemotherapy With limited toxicifes and broad applicability, Rituximab used in essenfally all mature B cell malignancies Vitamin R

17 Chronic myelogenous leukemia MyeloproliferaFve disorder Myeloid proliferafon Philadelphia chromosome (9:22 translocafon) TranslocaFon results in fusion gene BCR- ABL with enhanced proliferafon signaling Fatal disease Conversion to resistant AML in ~5 years Treatment Only curafve treatment is allo BMT Hydroxyurea controls blood counts but doesn t alter natural history

18 ImaFnib (Gleevec) Small molecule that binds to the BCR- ABL gene product InacFvates signaling Leads to apoptosis Oral agent taken daily ToxiciFes Myelosuppression Edema Headache

19 ImaFnib (Gleevec) Treatment with Gleevec Over 90% blood count and symptom control (hematologic remission) Over 70% will become negafve for Ph chromosome in cytogenefc tesfng (karyotypic remission) ~50% will have three log decrease in BCR- ABL transcript by peripheral blood PCR (major molecular remission PaFents with karyotypic remission have improved survival compared to allo BMT Probably not curafve

20 ImaFnib (Gleevec) Name was a problem for FDA approval Glivec changed to Gleevec Two addifonal agents DasaFnib (Sprycel) NiloFnib (Tasigna) CML in the Gleevec era

21 Melanoma Early stage disease curable with surgery PaFents with nodal metastases at high risk of recurrence ader surgery Adjuvant treatment with interferon controversial Distant metastafc disease generally incurable High dose IL- 2 ~5% cure Standard chemotherapy offers ~15% chance of response, high toxicity, no cures

22 BRAF BRAF is a member of a serine- threonine kinase family Regulates/modulates the MAP kinase signaling pathway affecfng cell division and differenfafon Inherited mutafons in BRAF cause birth defects Acquired mutafons in BRAF can cause cancer (Proto- oncogene) Approximately 60% of melanomas contain a common V600E mutafon in the BRAF gene

23 Vemurafinib (PLX4032, Zelboraf) Oral small molecule that targets the mutated BRAF protein Toxicity Skin rash, fafgue, arthralgia, skin cancer IniFal phase I and II studies in metastafc melanoma pafents show responses ~80 parfal response rate ~5% complete response Median durafon of response over 7 months

24 Vemurafinib (PLX4032, Zelboraf) Experience is limited as yet, but excifng response rate in a disease known for resistance to therapy Bar set low in melanoma Proof of value of drug discovery/development systems

25 Cost Major problem with targeted therapies is cost Gleevec $5000 to $8000 monthly HercepFn adjuvant treatment ~$75,000 Assistance programs Social work help PaFents with no insurance many Fmes beber able to get drug than those with some insurance

26 Summary Targeted therapies have made large strides in the last decade Improved treatment for many cancers Proof of drug discovery/development systems established Likely to see new drugs being developed at an increasing rate Cost remains a problem

27

28

What is New in Oncology. Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals

What is New in Oncology. Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals What is New in Oncology Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals Personalized Medicine Personalized Genomics Genomic Medicine Precision Medicine Definition Application

More information

Lauren Berger: Why is it so important for patients to get an accurate diagnosis of their blood cancer subtype?

Lauren Berger: Why is it so important for patients to get an accurate diagnosis of their blood cancer subtype? Hello, I m Lauren Berger and I m the Senior Director of Patient Services Programs at The Leukemia & Lymphoma Society. I m pleased to welcome Dr. Rebecca Elstrom. Dr. Elstrom is an Assistant Professor in

More information

The Treatment of Leukemia

The Treatment of Leukemia The Treatment of Leukemia Guest Expert: Peter, MD Associate Professor of Hematology Director, Yale Cancer Center Leukemia Program www.wnpr.org www.yalecancercenter.org Hi, I am Bruce Barber and welcome

More information

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can Shristi Pandey Genomics and Medicine Winter 2011 Prof. Doug Brutlag Chronic Myeloid Leukemia: A look into how genomics is changing the way we treat Cancer. Until the late 1990s, nearly all treatment methods

More information

Mantle Cell Lymphoma Understanding Your Treatment Options

Mantle Cell Lymphoma Understanding Your Treatment Options New Developments in Mantle Cell Lymphoma John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Associate Dean for Clinical Research Vice Chairman, Department

More information

Adjuvant Therapy for Breast Cancer: Questions and Answers

Adjuvant Therapy for Breast Cancer: Questions and Answers CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Adjuvant Therapy for Breast

More information

The CML Guide Information for Patients and Caregivers

The CML Guide Information for Patients and Caregivers The CML Guide Information for Patients and Caregivers LEUKEMIA LYMPHOMA CHRONIC MYELOGENOUS LEUKEMIA MYELOMA Printing of this publication made possible by a grant from A Message from John Walter President

More information

Cancer: DNA Synthesis, Mitosis, and Meiosis

Cancer: DNA Synthesis, Mitosis, and Meiosis Chapter 5 Cancer: DNA Synthesis, Mitosis, and Meiosis Copyright 2007 Pearson Copyright Prentice Hall, 2007 Inc. Pearson Prentice Hall, Inc. 1 What Is Cancer? Benign tumors do not invade surrounding tissue

More information

Targeted Chemotherapy: Guiding patients to more personalized care

Targeted Chemotherapy: Guiding patients to more personalized care Targeted Chemotherapy: Guiding patients to more personalized care Anna Hitron, Pharm.D, MS, MBA, BCOP Oncology Pharmacy Specialist Baptist Health Louisville September 10, 2015 Objectives Discuss the role

More information

I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several

I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several Track 3: Goals of therapy I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several factors she ll use to decide what s best for me. Let s talk about making treatment

More information

For patients with chronic myeloid leukemia ELECTRONIC MEDICAL DIARY

For patients with chronic myeloid leukemia ELECTRONIC MEDICAL DIARY The Chronic Myelogenous Leukemia Society of Canada La Société de la Leucemie Myéloide chronique du Canada ELECTRONIC MEDICAL DIARY For patients with chronic myeloid leukemia INTRODUCTION This electronic

More information

What s New With HER2?

What s New With HER2? What s New With HER2? Trastuzumab emtansine and pertuzumab for metastatic breast cancer Lindsay Livingston Pharmacist CancerCare Manitoba October 3, 2014 Presenter Disclosure Faculty: Lindsay Livingston

More information

CML. cure. A Patient s Guide. Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More

CML. cure. A Patient s Guide. Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More A Patient s Guide to CML Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More cure C a n c e r U p d at e s, R e s e a r c h & E d u c at i o n Based on science,

More information

Aggressive lymphomas. Michael Crump Princess Margaret Hospital

Aggressive lymphomas. Michael Crump Princess Margaret Hospital Aggressive lymphomas Michael Crump Princess Margaret Hospital What are the aggressive lymphomas? Diffuse large B cell Mediastinal large B cell Anaplastic large cell Burkitt lymphoma (transformed lymphoma:

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Ado-Trastuzumab Emtansine (Trastuzumab-DM1) for Treatment of File Name: Origination: Last CAP Review: Next CAP Review: Last Review: ado_trastuzumab_emtansine_(trastuzumab-dm1)_for_treatment_of_her-2_positivemalignancies

More information

Leukemias and Lymphomas: A primer

Leukemias and Lymphomas: A primer Leukemias and Lymphomas: A primer Normal blood contains circulating white blood cells, red blood cells and platelets 700 red cells (oxygen) 1 white cell Neutrophils (60%) bacterial infection Lymphocytes

More information

What are Tumor Markers?? A tumor marker is a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue t

What are Tumor Markers?? A tumor marker is a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue t Tumor Markers in breast Cancer By Dr.Hosny Badrawy Hamed Lecturer of clinical pathology South Egypt Cancer institute Assiut university What are Tumor Markers?? A tumor marker is a substance found in the

More information

Starting treatment early with PERJETA

Starting treatment early with PERJETA Starting treatment early with PERJETA A TREATMENT FOR HER2-POSITIVE EARLY BREAST CANCER GIVEN BEFORE SURGERY HER2 = human epidermal growth factor receptor 2. What does PERJETA treat? PERJETA (pertuzumab)

More information

Biological Therapies for Cancer

Biological Therapies for Cancer Biological Therapies for Cancer Key Points Biological therapies use the body's immune system to fight cancer or to lessen the side effects that may be caused by some cancer treatments. Biological therapies

More information

Acute Leukemia - D Savage - 8 January chronic leukemia lymphoma myeloma. differentiated

Acute Leukemia - D Savage - 8 January chronic leukemia lymphoma myeloma. differentiated Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Total WBC > 60 leukemoid reaction acute leukemia Blast Pro Myel Meta Band Seg Lymph 0 0 0 2 13 82 3 82

More information

Treatment of low-grade non-hodgkin lymphoma

Treatment of low-grade non-hodgkin lymphoma Produced 28.02.2011 Due for revision 28.02.2013 Treatment of low-grade non-hodgkin lymphoma Lymphomas are described as low grade if the cells appear to be dividing slowly. There are several kinds of low-grade

More information

Acute Leukemia - D Savage - 8 January differentiated. chronic leukemia lymphoma myeloma. Total WBC > 60. Blast Pro Myel Meta Band Seg Lymph

Acute Leukemia - D Savage - 8 January differentiated. chronic leukemia lymphoma myeloma. Total WBC > 60. Blast Pro Myel Meta Band Seg Lymph Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Total WBC > 60 leukemoid reaction acute leukemia Blast Pro Myel Meta Band Seg Lymph 0 0 0 2 13 82 3 82

More information

Chronic Myelogenous Leukemia

Chronic Myelogenous Leukemia Chronic Myelogenous Leukemia Willem van Heeckeren MD PhD Assistant Professor of Hematology/Oncology Case Western Reserve University School of Medicine Outline of CML Talk Brief Description of Pathophysiology

More information

Targeted therapies for Early Stage Breast Cancer. Cynthia Vakhariya D.O. Providence Hospital

Targeted therapies for Early Stage Breast Cancer. Cynthia Vakhariya D.O. Providence Hospital Targeted therapies for Early Stage Breast Cancer Cynthia Vakhariya D.O. Providence Hospital Case 55-year-old postmenopausal woman Routine screening mammogram 3 cm irreg mass in L breast Left breast ultrasound

More information

targeted therapy a guide for the patient

targeted therapy a guide for the patient targeted therapy FOR LUNG CANCER a guide for the patient TABLE OF CONTENTS lung cancer basics... 2-3 Gene changes... 4-5 Testing... 7-8 Targeted therapy... 9-11 Drugs Targeting EGFR... 12 Drugs Targeting

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div. Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under

More information

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer Breast Studies Adjuvant therapy after surgery Her 2 positive Breast Cancer B 52 Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients with Hormone

More information

Acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. Adult

More information

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR.

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. TRACEY O CONNOR RESEARCH QUESTON Patients with previously diagnosed hematologic

More information

New strategies in anticancer therapy

New strategies in anticancer therapy 癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 蔡 明 宏 醫 師 2014/3/29 Anti-Cancer Therapy Surgical Treatment Radiotherapy Chemotherapy Target Therapy Supportive

More information

Answering your questions on Chronic Myeloid Leukaemia (CML)

Answering your questions on Chronic Myeloid Leukaemia (CML) Answering your questions on Chronic Myeloid Leukaemia (CML) Your guide to understanding CML and Glivec (imatinib) treatment The information in this booklet is designed to help you understand chronic myeloid

More information

GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE

GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE Branko Zakotnik MD, PhD Department of Medical Oncology Institute of Oncology Ljubljana 1 I have no conflict of interest to declare

More information

MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS

MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS All prescriptions for antineoplastic drugs must be accompanied by the MOH special form. All the attachments mentioned on this form shall be submitted

More information

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT emerging treatments Presentation for: Judith E. Karp, MD Advancements for Acute Myelogenous Leukemia Supported by an unrestricted educational

More information

MEDICAL BREAKTHROUGHS RESEARCH SUMMARY

MEDICAL BREAKTHROUGHS RESEARCH SUMMARY MEDICAL BREAKTHROUGHS RESEARCH SUMMARY TOPIC: Training the Body to Fight Melanoma REPORT: 3823 BACKGROUND: Melanoma is the most dangerous form of skin cancer that can be hard to treat and fatal if not

More information

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15 Page: 1 of 6 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted

More information

A disease of populations of cells that live, divide, invade and spread without regard to normal limits

A disease of populations of cells that live, divide, invade and spread without regard to normal limits 1 Targeted Cancer Therapies Mark McKeage Medical Oncology Specialist Professor in Clinical Pharmacology 2 Cancer Definition- A disease of populations of cells that live, divide, invade and spread without

More information

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient Understanding series LUNG CANCER: new treatment directions 1-800-298-2436 LungCancerAlliance.org A guide for the patient TABLE OF CONTENTS What s New in lung cancer? Advancements...4 Changes in genes that

More information

Malignant Lymphomas and Plasma Cell Myeloma

Malignant Lymphomas and Plasma Cell Myeloma Malignant Lymphomas and Plasma Cell Myeloma Dr. Bruce F. Burns Dept. of Pathology and Lab Medicine Overview definitions - lymphoma lymphoproliferative disorder plasma cell myeloma pathogenesis - translocations

More information

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each Introduction 1.1 Introduction: About 10,500 new cases of acute myelogenous leukemia are diagnosed each year in the United States (Hope et al., 2003). Acute myelogenous leukemia has several names, including

More information

Cancer Clinical Trials

Cancer Clinical Trials Cancer Clinical Trials The Basic Workbook National Institutes of Health National Cancer Institute The National Cancer Institute Clinical Trials Education Series Cancer Clinical Trials Books Cancer Clinical

More information

The CML Guide. Information for Patients and Caregivers. Chronic Myeloid Leukemia. Matthew, CML survivor. This publication was supported by

The CML Guide. Information for Patients and Caregivers. Chronic Myeloid Leukemia. Matthew, CML survivor. This publication was supported by The CML Guide Information for Patients and Caregivers Chronic Myeloid Leukemia Matthew, CML survivor This publication was supported by Revised 2014 A Message from Louis J. DeGennaro, PhD President and

More information

BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader. Two years ago, I was working as a bedside nurse. One of my colleagues felt

BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader. Two years ago, I was working as a bedside nurse. One of my colleagues felt Ali A. Kader, S. (2010). Breast cancer awareness for women and men. UCQ Nursing Journal of Academic Writing, Winter 2010, 70 76. BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader Two years

More information

CHAPTER 26 LATE BREAKING DEVELOPMENTS: IMPACT OF ANTI-CD20 MONOCLONAL ANTIBODIES ON LYMPHOMA THERAPY

CHAPTER 26 LATE BREAKING DEVELOPMENTS: IMPACT OF ANTI-CD20 MONOCLONAL ANTIBODIES ON LYMPHOMA THERAPY CHAPTER 26 LATE BREAKING DEVELOPMENTS: IMPACT OF ANTI-CD20 MONOCLONAL ANTIBODIES ON LYMPHOMA THERAPY 26.1 Introduction rituximab Subsequent to the completion of drafts for the guidelines earlier in 2004,

More information

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME II LYMPHOMA CHAPTER 9 REVISED: OCTOBER 2014

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME II LYMPHOMA CHAPTER 9 REVISED: OCTOBER 2014 Disease Information The two main malignant diseases of the lymphoreticular system are non-hodgkin's lymphoma and Hodgkin's disease. Lymphoma is a general term applied to a heterogeneous group of cancers

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

I will be having surgery and radiation treatment for breast cancer. Do I need drug treatment too?

I will be having surgery and radiation treatment for breast cancer. Do I need drug treatment too? What is node-positive breast cancer? Node-positive breast cancer means that cancer cells from the tumour in the breast have been found in the lymph nodes (sometimes called glands ) in the armpit area.

More information

Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA

Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA Introduction This booklet is for anyone interested in learning more about leukemia. It explains the four main types of leukemia, how leukemia is diagnosed,

More information

Breakthrough Treatment Options for Breast Cancer

Breakthrough Treatment Options for Breast Cancer Breakthrough Treatment Options for Breast Cancer Guest Expert: Lyndsay, MD Associate Professor of Medical Oncology, Yale Cancer Center www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center

More information

1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT

1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT 1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT Learning that your pet has a diagnosis of cancer can be overwhelming. We realize that your pet

More information

Targeted Therapies in Lung Cancer

Targeted Therapies in Lung Cancer Targeted Therapies in Lung Cancer I Edited by: Simona Carnio Thoracic Oncology Division - St Luigi Hospital Orbassano (TO) - Italy Silvia Novello Department of Oncology - University of Torino - Italy Why

More information

Personalized Medicine and the Future of Lung Cancer Treatment David J. Stewart, MD, FRCPC

Personalized Medicine and the Future of Lung Cancer Treatment David J. Stewart, MD, FRCPC Personalized Medicine and the Future of Lung Cancer Treatment David J. Stewart, MD, FRCPC The Ottawa Hospital & University of Ottawa Head, Division of Medical Oncology Consulting: Align2Action, Inc Amgen

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

Metastatic Melanoma What You Need to Know

Metastatic Melanoma What You Need to Know ESSENTIALS Metastatic Melanoma Metastatic Melanoma What You Need to Know If you have metastatic melanoma, you may feel as though your life has been turned upside down. It s a serious disease, but patients

More information

Chugai Pharmaceutical Co., Ltd. Oncology Area, Scientific Group 2, Breast Cancer Group Takehiro Yamaguchi, Herceptin Product Manager

Chugai Pharmaceutical Co., Ltd. Oncology Area, Scientific Group 2, Breast Cancer Group Takehiro Yamaguchi, Herceptin Product Manager Anti-malignant Tumor Agent with Anti-HER2 Humanized Monoclonal Antibody: Biologics, Designated drug, Prescription drug HERCEPTIN Injection 60 HERCEPTIN Injection 150 Trastuzumab (genetical recombination)

More information

Understanding How Existing and Emerging MS Therapies Work

Understanding How Existing and Emerging MS Therapies Work Understanding How Existing and Emerging MS Therapies Work This is a promising and hopeful time in the field of multiple sclerosis (MS). Many new and different therapies are nearing the final stages of

More information

Lymphoma Cancer Treatment

Lymphoma Cancer Treatment Scan for mobile link. Lymphoma Cancer Treatment What is Lymphoma? Lymphoma is a cancer that develops in the white blood cells (lymphocytes) of the lymphatic system, which is part of the body s immune system.

More information

Report series: General cancer information

Report series: General cancer information Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for

More information

Monoclonal Antibody. By Dr. Adel Gabr

Monoclonal Antibody. By Dr. Adel Gabr Monoclonal Antibody By Dr. Adel Gabr Terminology Immunotherapy Monoclonal antibody Biotherapy Biological therapy Target therapy TKIs Cancer vaccine Types of targeted therapy used today Today many different

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

Adjuvant and Neoadjuvant Therapy for Breast Cancer

Adjuvant and Neoadjuvant Therapy for Breast Cancer Adjuvant and Neoadjuvant Therapy for Breast Cancer Key Points Adjuvant therapy for breast cancer is any treatment given after primary therapy to increase the chance of long-term survival. Neoadjuvant therapy

More information

Main Street Planning Group 180 East Main Street Suite 110 Patchogue, NY 11772 Tel: 631.647.4694 Fax: 631.647.4697 MainStreetPlanningGroup.

Main Street Planning Group 180 East Main Street Suite 110 Patchogue, NY 11772 Tel: 631.647.4694 Fax: 631.647.4697 MainStreetPlanningGroup. Main Street Planning Group 180 East Main Street Suite 110 Patchogue, NY 11772 Tel: 631.647.4694 Fax: 631.647.4697 MainStreetPlanningGroup.com Presented by Ted Mageau Ted@MainStreetPlanningGroup.com Life

More information

Frequency of NHL Subtypes in Adults

Frequency of NHL Subtypes in Adults Chemotherapy Options Stephanie A. Gregory, M.D. The Elodia Kehm Professor of Medicine Director, Section of Hematology Rush University Medical Center Chicago, Illinois Frequency of NHL Subtypes in Adults

More information

X-Plain Chemotherapy for Breast Cancer - Adriamycin, Cytoxan, and Tamoxifen Reference Summary

X-Plain Chemotherapy for Breast Cancer - Adriamycin, Cytoxan, and Tamoxifen Reference Summary X-Plain Chemotherapy for Breast Cancer - Adriamycin, Cytoxan, and Tamoxifen Reference Summary Introduction Breast cancer is a common condition that affects one out of every 11 women. Your doctor has recommended

More information

CANCER TREATMENT: Chemotherapy

CANCER TREATMENT: Chemotherapy CANCER TREATMENT: Chemotherapy Chemotherapy, often called chemo, is the use of drugs to treat a disease. The term chemotherapy is now most often used to describe a type of cancer treatment. Dr. Khuri:

More information

What is a Stem Cell Transplantation?

What is a Stem Cell Transplantation? What is a Stem Cell Transplantation? Guest Expert: Stuart, MD Associate Professor, Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Drs. Ed and Ken. I am

More information

Cancer Clinical Trials: In-Depth Information

Cancer Clinical Trials: In-Depth Information Cancer Clinical Trials: In-Depth Information The Drug Development and Approval Process 1. Early research and preclinical testing 2. IND application filed with FDA 3. Clinical trials (phases 1, 2, and 3)

More information

Genomic Analysis of Mature B-cell Malignancies

Genomic Analysis of Mature B-cell Malignancies Genomic Analysis of Mature B-cell Malignancies Update and Lessons Learned Omar Abdel-Wahab, MD Memorial Sloan Kettering Cancer Center Human Oncology and Pathogenesis Program and Leukemia Service Disclaimer:

More information

Florida Breast Health Specialists Breast Cancer Information and Facts

Florida Breast Health Specialists Breast Cancer Information and Facts Definition Breast cancer is a cancer that starts in the tissues of the breast. There are two main types of breast cancer: Ductal carcinoma starts in the tubes (ducts) that move milk from the breast to

More information

Treatment of Breast Cancer after Surgery. What Primary Care Providers Need to Know

Treatment of Breast Cancer after Surgery. What Primary Care Providers Need to Know Treatment of Breast Cancer after Surgery What Primary Care Providers Need to Know Disclosure of Potential for Conflict of Interest Dr. Chris Ogaranko Treatment of Breast Cancer after Surgery FINANCIAL

More information

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL) Chronic Lymphocytic Leukemia (CLL) Introduction Chronic lymphocytic leukemia (CLL) is a type of cancer of the lymphocytes (a kind of white blood cell). The variant of this disease in which there are not

More information

ACUTE MYELOID LEUKEMIA (AML),

ACUTE MYELOID LEUKEMIA (AML), 1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly

More information

Cancer in Children. What is cancer?

Cancer in Children. What is cancer? What is cancer? Cancer in Children The body is made up of trillions of living cells. Normal body cells grow, divide to make new cells, and die in an orderly fashion. During the early years of a person

More information

A 43 year old male presents with abdominal complaints. An axial CT reveals.

A 43 year old male presents with abdominal complaints. An axial CT reveals. A 43 year old male presents with abdominal complaints. An axial CT reveals. Diagnosis: Gastrointestinal Stromal Tumor Location: stomach Size: 12 cm Mitotic count: 10 mitoses / 50 high power fields Risk

More information

Cytogenetics for the Rest of Us: A Primer

Cytogenetics for the Rest of Us: A Primer Cytogenetics for the Rest of Us: A Primer James J. Stark, MD, FACP Medical Director Cancer Program Maryview Medical Center Diane Maia, M.D. Pathologist, Bon Secours Hampton Roads Case #1 78 y.o. lady seen

More information

MALIGNANT LYMPHOMAS. Dr. Olga Vujovic (Updated August 2010)

MALIGNANT LYMPHOMAS. Dr. Olga Vujovic (Updated August 2010) MALIGNANT LYMPHOMAS Dr. Olga Vujovic (Updated August 2010) Malignant lymphomas consist of Hodgkin and non-hodgkin lymphomas. The current management of these diseases involves a multi-disciplinary approach.

More information

What is non-hodgkin lymphoma, how is it treated, and what is the unmet need?

What is non-hodgkin lymphoma, how is it treated, and what is the unmet need? What is non-hodgkin lymphoma, how is it treated, and what is the unmet need? Tim Illidge BSc PhD MRCP FRCR FRCPath Institute of Cancer Sciences, University of Manchester Manchester Cancer Research Centre,

More information

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function:

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function: Cancer is a genetic disease: Inherited cancer Sporadic cancer What is Cancer? Cancer typically involves a change in gene expression/function: Qualitative change Quantitative change Any cancer causing genetic

More information

Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system.

Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system. MayoClinic.com reprints This single copy is for your personal, noncommercial use only. For permission to reprint multiple copies or to order presentation-ready copies for distribution, use the reprints

More information

Haematopoietic Chimerism Analysis after Allogeneic Stem Cell Transplantation

Haematopoietic Chimerism Analysis after Allogeneic Stem Cell Transplantation Haematopoietic Chimerism Analysis after Allogeneic Stem Cell Transplantation Dr Ros Ganderton, Ms Kate Parratt, Dr Debbie Richardson, Dr Kim Orchard and Dr Liz Hodges Departments of Molecular Pathology

More information

Michael Crump MD. Lymphoma Site Leader Princess Margaret Hospital University of Toronto

Michael Crump MD. Lymphoma Site Leader Princess Margaret Hospital University of Toronto Evolution of Lymphoma Therapy: What can we expect for the rest of the millenium decade? Michael Crump MD Lymphoma Site Leader Princess Margaret Hospital University of Toronto disclaimers Served on advisory

More information

Interesting Case Review. Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA

Interesting Case Review. Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA Interesting Case Review Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA History 63 y/o male with h/o CLL for 10 years Presents with worsening renal function and hypercalcemia

More information

TABLE OF CONTENTS. Introduction...1. Chapter1 AdvancesinTreatment...2. Chapter2 MedicinesinDevelopment...11. Chapter3 ValueandSpending...

TABLE OF CONTENTS. Introduction...1. Chapter1 AdvancesinTreatment...2. Chapter2 MedicinesinDevelopment...11. Chapter3 ValueandSpending... CANCER TABLE OF CONTENTS Introduction...1 Chapter1 AdvancesinTreatment...2 Chapter2 MedicinesinDevelopment......11 Chapter3 ValueandSpending......15 Chapter4 Conclusion...22 INTRODUCTION Researchers and

More information

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA UNFAVORABLE Advanced age High leukocyte count at diagnosis Presence of myeloid antigens Late achievement of CR Chromosomal abnormalities: t(9:22)(q34:q11) t(4;11)(q21;q23)

More information

Future Oncology: Technology, Products, Market and Service Opportunities

Future Oncology: Technology, Products, Market and Service Opportunities Brochure More information from http://www.researchandmarkets.com/reports/296370/ Future Oncology: Technology, Products, Market and Service Opportunities Description: Future Oncology is an analytical newsletter

More information

CHRONIC MYELOGENOUS LEUKEMIA

CHRONIC MYELOGENOUS LEUKEMIA CHRONIC MYELOGENOUS LEUKEMIA Executive Summary We propose the inclusion of treatment options for chronic myelogenous leukemia (CML), in the category of anti-neoplastic agents, including imatinib, nilotinib,

More information

Fact Sheet: Molecular Imaging and Cancer

Fact Sheet: Molecular Imaging and Cancer Fact Sheet: Molecular Imaging and Cancer Cancer causes one in every four deaths in the United States, second only to heart disease. According to the American Cancer Society, an estimated 1.48 million new

More information

NON-HODGKIN S LYMPHOMA FACTSHEET

NON-HODGKIN S LYMPHOMA FACTSHEET What is Non-Hodgkin's Lymphoma? Non-Hodgkin's lymphoma is a cancer which affects cells in the lymphatic system called lymphocytes. The various types of non-hodgkin's lymphoma are divided into 'high grade'

More information

Future strategies for myeloma: An overview of novel treatments In development

Future strategies for myeloma: An overview of novel treatments In development Future strategies for myeloma: An overview of novel treatments In development Dr. Matthew Streetly Guys and St. Thomas NHS Trust How far have we come? Melphalan and prednisolone VAD Autologous SCT Thalidomide

More information

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used?

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used? Dr. Anthony C.H. YING What are? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer cells or

More information

Triple Negative Breast Cancer. Disclosures. Objectives 5/1/2015. Deborah K Walker, DNP, CRNP, AOCN Assistant Professor/Nurse Practitioner

Triple Negative Breast Cancer. Disclosures. Objectives 5/1/2015. Deborah K Walker, DNP, CRNP, AOCN Assistant Professor/Nurse Practitioner Triple Negative Breast Cancer Deborah K Walker, DNP, CRNP, AOCN Assistant Professor/Nurse Practitioner Disclosures I have nothing to disclose in relation to the TNBC presentation. Objectives Improve understanding

More information

The Immune System A collection of organs, cells, and substances that protect against infections and some disease (including cancers).

The Immune System A collection of organs, cells, and substances that protect against infections and some disease (including cancers). Biotherapy The Immune System A collection of organs, cells, and substances that protect against infections and some disease (including cancers). The Problem: Part 1 Although the immune system has the potential

More information

DECISION QUALITY WORKSHEET FOR CHEMOTHERAPY AND HORMONE THERAPY

DECISION QUALITY WORKSHEET FOR CHEMOTHERAPY AND HORMONE THERAPY DECISION QUALITY WORKSHEET FOR CHEMOTHERAPY AND HORMONE THERAPY Instructions This survey has questions about what it is like for you to make decisions about chemotherapy and hormone therapy for your early

More information

What You Need to Know About Lung Cancer Immunotherapy

What You Need to Know About Lung Cancer Immunotherapy What You Need to Know About Lung Cancer Immunotherapy Lung.org/immunotherapy What is immunotherapy? Immunotherapy for cancer, sometimes called immune-oncology, is a type of medicine that treats cancer

More information

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation

More information

David Loew, LCL MabThera

David Loew, LCL MabThera MabThera The star continues to rise David Loew, LCL MabThera MabThera the star continues to raise Group sales (CHF bn) 4,5 4,0 3,5 3,0 2,5 2,0 1,5 1,0 0,5 0,0 2001 2002 2003 2004 2005 Outstanding clinical

More information

Cellular, Molecular, and Biochemical Targets in Breast Cancer

Cellular, Molecular, and Biochemical Targets in Breast Cancer Cellular, Molecular, and Biochemical Targets in Breast Cancer Kristy Kummerow Ingrid Meszoely December 12, 2012 VUMC Resident Bonus Conference One size fits all surgical treatment of breast cancer Wilhelm

More information

Metastatic Breast Cancer 201. Carolyn B. Hendricks, MD October 29, 2011

Metastatic Breast Cancer 201. Carolyn B. Hendricks, MD October 29, 2011 Metastatic Breast Cancer 201 Carolyn B. Hendricks, MD October 29, 2011 Overview Is rebiopsy necessary at the time of recurrence or progression of disease? How dose a very aggressive treatment upfront compare

More information