Stegane natural products
|
|
- Shon Patterson
- 8 years ago
- Views:
Transcription
1 Me Me Me Indroduction: Steganone -Isolation from Steganotaenia araliacea in 1972 from Kupchan -Belong to the category of lignans Biological Properties: -Significant activity in vivo against P-388 leukemia in mice and in vitro against cells derived from human carcinoma of the nasopharynx Synthesis of : -First synthesis in 1976 by Kende -ine total synthesis of racemic stegane natural products. -Five total synthesis of asymmetric stegane natural products Me Me Me R R: Ac Steganacin R: Steganol R: C steganangin Total synthesis of Steganacin (Kende et al. JACS, 1976, 98, 267) on enolic oxidation methodology VF3 45% Me Me C 2 Et Me Me MsCl, Et3 C 2 Et Me C 2 Et C 2 Et Me Me Me Me C 2 Et C 2 Et C 2 a, DMF 0 0 C 52% Cr 3 -pyridine 60% Ms Et 2 C Me C 2Et Me 1.BS-CCl 4, benzoyl peroxide 2.AgCCF 4 3.aq Et 3 Me ac(c2et)2, Ar reflux Me Me C 2 Et C 2 Et Me
2 Total synthesis of Steganacin Kende et al.(continue) on enolic oxidation methodology C 2 Et 1.K- 2 C 2 Et C Me 95% Me Me - -C 2 ab4 C Me Me Me Me 77% Me Me Me Me Me epi-steganole Ac Ac 2 -pyridine Me Me Me Me Me Me Steganacin steganole ratio 55:45 Total synthesis of Steganacin (Ziegler et al. JACS, 1980, 102, 790) Application of Ullmann Reaction MeI, 2 acetone t-buk, t-bu 73% S Me Me 1.n-BuLi, TF 2.CuI. (Et) 3 P Me Me M C 2 Me C 2 Me Me 1. S M=Li M=CuP(Et) 3 Me Me 1.Raney i, 2 1atm 2.C 6 5 3, DCM C 2 Me Me Me C 2 Me I C 2.20%Ac 3.malonate,reflux 82% Me Me Me Y Y=SC 2 C 2, Z=C 6 11 Y=SC 2 C 2, Z= Y=SC 2 C 2, Z=C(C 2 Me) 2 Me Me Me Steganacin Z C 2 Me C 2 Me
3 Total synthesis of Steganacin Ziegler et al.(continue) Application of Ullmann Reaction Me Me Me C 2 Me C 2 Me K, 2 xylenes reflux Me Me Me C ratio 1:1 C Total synthesis of Steganacin (by Raphael. J. Chem Soc Perkin Trans 1, 1977, 1674) Use of phenanthrene derivatives aq. DMS 74% CCl Me Me Me Me C 2 Bu t Pyrrolidine 88% LDA, TF Me Me Me Me R 2 C 2 Bu t Me Me Me Me Me Me Me isosteganone hv liq. 3 t-buk R 2 C 2 Me C 2 Me R 2 C 2 Me 65% Me 91% Me C 2 Me Me Me Me Me
4 Total synthesis of Steganacin by Raphael (continue) Use of phenanthrene derivatives Me Me Me 1.Raney i 2 2. Jones oxidation 3.Base 95% R 2 Me Me C 2 Me C 2 Me Me Cl Me 90% Me Me 1.K, C 2.Jones oxidation C 75% Me Me Me C 2 Me Steganacin Me 23% overall yield Me Me Total synthesis of Steganone Magnus et al. (J. Am. Chem. Soc. 1985, 4984) A [7,3] ring expansion Me Me Me Me Tl(CCF 3 ) 3 TFA, 0 0 C 43% Me 2 CC 2 P()(Et) 2 a C 2 Me Me Me Me Me 2 S ()C 3 I - a 82% C 2 Me Me Me Et Et DIBAL P Me Me Me C 2 Me Me Me Me Me piperonal a 38% 2:1 C 2 Me C 2
5 Total synthesis of Steganone Magnus et al. (continue) A [7,3] ring expansion Me Me Me Jones oxidation Me Me C 2 Me 1.Ac, Aca, Cl 4, 45 0 C Me 2.B 3, TF , a 4. K 2 C 3, 2 Me C Me Steganone Asymmetric Total synthesis of (-)Steganone Robin et al. (Tetrahedron Lett., 1980, 21, 2709) ai 4 t Bu Me Tr Ar 2 C LDA, ArC 2 TF C Ar 2 C I 2, CF 3 C 2 Ag Me Me LDS, Ar 10 0 C Tr 1.LA, TF 2. 2, Pd/C I Me Ar 2 C Me C 2 C 2 C Cu, C C 2 Me Me Me Me 1.Cr 3, acetone 2.C, K 3.Cr 3, acetone xylenes reflux Me Me Me Me Me Me (-)Steganone
6 Asymmetric Total synthesis of (-)Steganone Meyers et al. (JACS., 1987, 109, 5447) Me Me Me 1.C 2 2 Cl 2, 3 2.Et 3 BF 4 Mg 1. 2.MeMg C 2 Me Me Me Me Me Me Me Me Me Me Me 2 Me 85% Et Me Me Me C 2 a Me Me Me I Mea Cu Me Me Me Me Me Me Me 9% Me Me Me C Me Me Me Me 1.BS 2. - C(C 2 Me) 2 t-buk Me Me Me Me Me Me Me C 2 Me C 2 Me 1. 2 S 4 2.LA C 2 Me C 2 Me Me Me 1.( 2 P) 3 RhCl 2.gCl 2 -g 3.C C C 4.Jones ox Me Me Me (-)Steganone Me C 2 Me C 2 Me
Wittig Reaction - Phosphorous Ylides
Wittig eaction - osphorous Ylides 3 P CC 3 3 C ylide tereoselectivity increases as the size of increases cis-olefin is derived from non-stabilized ylides Mechanism: Irreversible [22] cycloaddition P 3
More informationDavid W. C. MacMillan Career-in-Review. Sujun Wei BreslowGroup Columbia University September 28, 2007
David W. C. MacMillan Career-in-Review Sujun Wei BreslowGroup Columbia University September 28, 2007 Biography 1968: Born in Bellshill, Scotland 1987-1991: B.S. at the University of Glasgow, Scotland 1991-1996:.D.
More informationVitamin B 12. structure & modifications. Mikołaj Chromiński Group XV Institute of Organic Chemistry PAS
Vitamin B 12 structure & modifications Mikołaj Chromiński Group XV Institute of rganic Chemistry PAS Introduction Structure omenclature (not only) according to IUPAC Possible modifications Modifications
More informationFIVE-MEMBERED RING FORMATION 138. 5 Membered Rings. Intramolecular S N 2 Reaction
5 mbered ings FIVE-MEMBEED IG FMATI 138 C 2 C 2 PGF 2α PGE 2 irsutene Modhephane Isocumene 1. Intramolecular S 2 eactions 2. Intramolecular Aldol Condensation and Michael Addition 3. Intramolecular Wittig
More informationammonium salt (acidic)
Chem 360 Jasperse Ch. 19 otes. Amines 1 eactions of Amines 1. eaction as a proton base (Section 19-5 and 19-6) amine base -X (proton acid) a X ammonium salt (acidic) Mechanism: equired (protonation) everse
More informationAcceptance Page 2. Revision History 3. Introduction 14. Control Categories 15. Scope 15. General Requirements 15
Acceptance Page 2 Revision History 3 Introduction 14 Control Categories 15 Scope 15 General Requirements 15 Control Category: 0.0 Information Security Management Program 17 Objective Name: 0.01 Information
More informationStille, Suzuki, and Sonogashira Couplings Cross-Coupling reactions: catalyst R-X + R'-M
Stille, Suzuki, and Sonogashira Couplings Cross-Coupling reactions: catalyst -X '-M -' M-X, ' are usually sp 2 hybridized X= (best), Tf, r, Cl M=Sn,, Zn, Zr, n Catalyst= Pd, sometimes Ni Example: Pd(0)
More informationCalifornia State Polytechnic University, Pomona. Exam Points 1. Nomenclature (1) 30
Chem 316 Final Exam Winter, 2008 Beauchamp ame: Topic Total Points Exam Points 1. omenclature (1) 30 Credit 2. Explanation of elative eactivities of Aromatic 20 Compounds or Carbonyl Compounds 3. eactions
More informationChapter 3: Protecting Groups
I. Protecting Groups of Hydroxyl Groups Chapter 3: Protecting Groups Consider the stability and effect of anomeric group! Consider the solubility of starting material (the choice of solvent)! Consider
More informationA Perspective on Professor Scott Eric Denmark: The Man, The Myth, The Chemist O
A Perspective on Professor Scott Eric Denmark: The Man, The Myth, The Chemist Si 3 2 C 2 S P (C 2 ) 5 2 n-c 5 9 ussell C. Smith Stoltz/eisman Group eting January 24, 2011 Si M From umble Beginnings Born
More informationDHL EXPRESS CANADA E-BILL STANDARD SPECIFICATIONS
DHL EXPRESS CANADA E-BILL STANDARD SPECIFICATIONS 1 E-Bill Standard Layout A B C D E F G Field/ DHL Account Number Billing Customer Name Billing Customer Address Billing Customer City Billing Customer
More informationCHM1 Review Exam 12. Topics REDOX
CHM1 Review Exam 12 Topics REDOX REDOX Reactions Oxidation Reduction Oxidizing agent Reducing agent Galvanic (Voltaic) Cells Anode Cathode Salt bridge Electrolyte Half-reactions Voltage o Positive voltages
More informationChemistry B11 Chapter 4 Chemical reactions
Chemistry B11 Chapter 4 Chemical reactions Chemical reactions are classified into five groups: A + B AB Synthesis reactions (Combination) H + O H O AB A + B Decomposition reactions (Analysis) NaCl Na +Cl
More informationAsymmetric Epoxidation of Pentadienols
10 Asymmetric Epoxidation of Pentadienols Asymmetric Epoxidation of Pentadienols Reinhard Brçckner, University of Freiburg, Germany Background The asymmetric epoxidation of allylic alcohols or Sharpless
More informationCleavage of Cyclobutanols and Cyclobutanones
Literature Report VII Transition Metal-Catalyzed Enantioselective C-C C Bond Cleavage of Cyclobutanols and Cyclobutanones Huang, W.-X. checker: Yu, C.-B. 2014-04-2904 29 1 Contents 1. Background Information
More informationKurs: Metallorganische Reagenzien. Cericammoniumnitrate (CAN)
Kurs: Metallorganische eagenzien Cericammoniumnitrate (CAN) by Laura Munoz Senovilla and Arthur Fedoseev. CAN as one-electronelectron oxidant CAN as one-electron electron oxidant Based on: Salt of high-valent
More informationShort Peptide Synthesis
Short Peptide Synthesis Keith ó Proinsias 8 th February 2010 Introduction Amide bond and basic amide synthesis Solution phase peptide synthesis Protecting groups required for peptide synthesis Coupling
More informationPotassium ion charge would be +1, so oxidation number is +1. Chloride ion charge would be 1, so each chlorine has an ox # of -1
Chapter 18-1 1. Assign oxidation numbers to each atom in: Ni Nickel ion charge would be +2, so oxidation number is +2 Chloride ion charge would be 1, so each chlorine has an ox # of -1 Mg 2 Ti 4 Magnesium
More informationCHEM 105 HOUR EXAM III 28-OCT-99. = -163 kj/mole determine H f 0 for Ni(CO) 4 (g) = -260 kj/mole determine H f 0 for Cr(CO) 6 (g)
CHEM 15 HOUR EXAM III 28-OCT-99 NAME (please print) 1. a. given: Ni (s) + 4 CO (g) = Ni(CO) 4 (g) H Rxn = -163 k/mole determine H f for Ni(CO) 4 (g) b. given: Cr (s) + 6 CO (g) = Cr(CO) 6 (g) H Rxn = -26
More informationProperties of Silicon
Properties of Silicon afensteiner Si vs. C - Si is less electronegative than C - More facile nucleophilic addition at Si center Average BDE (kcal/mol) C C C Si Si Si C F Si F 83 76 53 116 135 C Si C Si
More informationCh 20 Electrochemistry: the study of the relationships between electricity and chemical reactions.
Ch 20 Electrochemistry: the study of the relationships between electricity and chemical reactions. In electrochemical reactions, electrons are transferred from one species to another. Learning goals and
More informationpka's of Inorganic and Oxo-Acids
's of Inorganic and xo-acids ubstrate 2 3 2 Br Cl F Cl Cl 4 C 3 C 2 3 2 4 3 P 4 3 2 2 Cr 4 C 3 3 3 4 Cl B() 3 IRGAIC ACID Table.1 11/4/05 1:43 PM 2 15.7-1.7 7.00-9.00-8.0 3.17 7.5-10 9.4 4.72 4.00-14 11.6
More informationName Electrochemical Cells Practice Exam Date:
Name Electrochemical Cells Practice Exam Date: 1. Which energy change occurs in an operating voltaic cell? 1) chemical to electrical 2) electrical to chemical 3) chemical to nuclear 4) nuclear to chemical
More informationChem 115 POGIL Worksheet - Week 4 Moles & Stoichiometry Answers
Key Questions & Exercises Chem 115 POGIL Worksheet - Week 4 Moles & Stoichiometry Answers 1. The atomic weight of carbon is 12.0107 u, so a mole of carbon has a mass of 12.0107 g. Why doesn t a mole of
More informationElectrochemistry Worksheet
Electrochemistry Worksheet 1. Assign oxidation numbers to each atom in the following: a. P 4 O 6 b. BiO 3 c. N 2 H 4 d. Mg(BrO 4 ) 2 e. MnSO 4 f. Mn(SO 4 ) 2 2. For each of the reactions below identify
More informationAllyl Metals. oxidative addition. transmet. + M(n) η 1 -allyl. n = 0, 1. base. X η 3 -allyl. Nuc. insertion. insertion. M(n+2)X MgX + MX2 MX 2
Allyl tals Virtually all transition metals can form η 3 -allyl complexes, but few are synthetically useful. Pd is most widely studied and has broad utility. Allyl complexes of h, Ir, u and Mo are becoming
More informationAvg. 16.4 / 25 Stnd. Dev. 8.2
QUIZ TREE Avg. 16.4 / 25 Stnd. Dev. 8.2 xidation of Alcohols with Chromium (VI): Jones xidation 2 Alcohols are oxidized by a solution of chromium trioxide in aqueous acetone (2), in the presence of an
More informationFuture Trends in Airline Pricing, Yield. March 13, 2013
Future Trends in Airline Pricing, Yield Management, &AncillaryFees March 13, 2013 THE OPPORTUNITY IS NOW FOR CORPORATE TRAVEL MANAGEMENT BUT FIRST: YOU HAVE TO KNOCK DOWN BARRIERS! but it won t hurt much!
More informationChemistry 122 Mines, Spring 2014
Chemistry 122 Mines, Spring 2014 Answer Key, Problem Set 9 1. 18.44(c) (Also indicate the sign on each electrode, and show the flow of ions in the salt bridge.); 2. 18.46 (do this for all cells in 18.44
More informationSupplementary Information. Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes.
This journal is (c) The Royal Society of Chemistry 8 Supplementary Information Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes. Atsushi
More informationReview: Balancing Redox Reactions. Review: Balancing Redox Reactions
Review: Balancing Redox Reactions Determine which species is oxidized and which species is reduced Oxidation corresponds to an increase in the oxidation number of an element Reduction corresponds to a
More informationo Electrons are written in half reactions but not in net ionic equations. Why? Well, let s see.
REDOX REACTION EQUATIONS AND APPLICATIONS Overview of Redox Reactions: o Change in Oxidation State: Loses Electrons = Oxidized (Oxidation number increases) Gains Electrons = Reduced (Oxidation Number Reduced)
More informationSynthesis of alkynylated chromones with Sonogashira reaction
Theses of doctoral (PhD) dissertation Synthesis of alkynylated chromones with Sonogashira reaction Ábrahám Anita Supervisor : Dr. Patonay Tamás University of Debrecen Doctoral School of Chemistry Debrecen,
More informationChem 115 POGIL Worksheet - Week 4 Moles & Stoichiometry
Chem 115 POGIL Worksheet - Week 4 Moles & Stoichiometry Why? Chemists are concerned with mass relationships in chemical reactions, usually run on a macroscopic scale (grams, kilograms, etc.). To deal with
More informationChem 1721 Brief Notes: Chapter 19
Chem 1721 Brief Notes: Chapter 19 Chapter 19: Electrochemistry Consider the same redox reaction set up 2 different ways: Cu metal in a solution of AgNO 3 Cu Cu salt bridge electrically conducting wire
More informationFinal GCE Timetable Summer 2015
Final GCE table Summer 2015 1 GCE A/AS Modern Languages Speaking Tests Tuesday 28 April - Friday 29 2015 2 GCE Religious Studies: where candidates are taking two assessment units which have been timetabled
More informationThe first law: transformation of energy into heat and work. Chemical reactions can be used to provide heat and for doing work.
The first law: transformation of energy into heat and work Chemical reactions can be used to provide heat and for doing work. Compare fuel value of different compounds. What drives these reactions to proceed
More informationSupporting Information. Minimum active structure of insulin-like. peptide 5 (INSL5)
Supporting Information Minimum active structure of insulin-like peptide 5 (INSL5) Alessia Belgi 1,2, Ross A.D. Bathgate *1,2,3, Martina Kocan *4, Nitin Patil 1,5, Suode Zhang 1, Geoffrey W. Tregear 1,2,
More informationUnexpected course of a Williamson ether synthesis
Issue in onor of Prof. Atta-ur-Rahman ARKIVC 2007 (vii) 291-300 Unexpected course of a Williamson ether synthesis Klaus-Peter Zeller, a * Peter aiss, a Meike artmann, a and Klaus Eichele b a Institut für
More informationStudies directed on the synthesis of Vancomycin and related cyclic peptides
Pure & Appl. Chem., Vol. 70, No. 2, pp. 391-396, 1998. Printed in Great Britain. (0 1998 IUPAC Studies directed on the synthesis of Vancomycin and related cyclic peptides A V Rama Rao A V Rama Rao Research
More informationSEATTLE CENTRAL COMMUNITY COLLEGE DIVISION OF SCIENCE AND MATHEMATICS. Oxidation-Reduction
SEATTLE CENTRAL COMMUNITY COLLEGE DIVISION OF SCIENCE AND MATHEMATICS OxidationReduction Oxidation is loss of electrons. (Oxygen is EN enough to grab e away from most elements, so the term originally meant
More informationMetal catalysed asymmetric epoxidation of olefins
Metal catalysed asymmetric epoxidation of olefins First report: chiral molybdenum peroxo complexes squalene Mo 2 (acac) 2, di-isopropyl tartrate 14% ee S tsuka et al, Tetrahedron Lett. 1979, 3017 Iron
More informationB I N G O B I N G O. Hf Cd Na Nb Lr. I Fl Fr Mo Si. Ho Bi Ce Eu Ac. Md Co P Pa Tc. Uut Rh K N. Sb At Md H. Bh Cm H Bi Es. Mo Uus Lu P F.
Hf Cd Na Nb Lr Ho Bi Ce u Ac I Fl Fr Mo i Md Co P Pa Tc Uut Rh K N Dy Cl N Am b At Md H Y Bh Cm H Bi s Mo Uus Lu P F Cu Ar Ag Mg K Thomas Jefferson National Accelerator Facility - Office of cience ducation
More informationTetrabutylammoniumbromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids
Tetrabutylammoniumbromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids Monika Gupta a * and Basant Purnima Wakhloo b a Department of Chemistry, University of Jammu, Jammu-180
More informationSYNTHETIC STUDIES ON TULEARIN MACROLIDES. M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo
SYNTHETIC STUDIES N TULEARIN MACRLIDES M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain E-mail: mmartinezc@udc.es
More information2. DECOMPOSITION REACTION ( A couple have a heated argument and break up )
TYPES OF CHEMICAL REACTIONS Most reactions can be classified into one of five categories by examining the types of reactants and products involved in the reaction. Knowing the types of reactions can help
More information5.111 Principles of Chemical Science
MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Page 1 of 10 pages
More informationRedox and Electrochemistry
Name: Thursday, May 08, 2008 Redox and Electrochemistry 1. A diagram of a chemical cell and an equation are shown below. When the switch is closed, electrons will flow from 1. the Pb(s) to the Cu(s) 2+
More information1. COUPLING REAGENTS : Structure and acronyms
Coupling Reagents 1. COUPLING REAGENTS : Structure and acronyms... 2 2. CARBODIIMIDE... 3 1.a. N,N -Dicyclohexylcarbodimide (DCC)... 3 DCC/HOBt coupling experimental procedure:... 4 1.b. N-(3-Dimethylaminopropyl)-N
More informationNovel Method for Solid Phase Peptide Synthesis Using Microwave Energy
Novel Method for Solid Phase Peptide Synthesis Using Microwave Energy Jonathan M. Collins, Michael J. Collins, Rebecca C. Steorts CEM Corporation, Matthews, NC 28106-0200, U.S.A. Presented at American
More informationPreliminary Concepts. Preliminary Concepts. Class 8.3 Oxidation/Reduction Reactions and Electrochemistry I. Friday, October 15 Chem 462 T.
Class 8.3 Oxidation/Reduction Reactions and Electrochemistry I Friday, October 15 Chem 462 T. Hughbanks Preliminary Concepts Electrochemistry: the electrical generation of, or electrical exploitation of
More informationChapter 11. Electrochemistry Oxidation and Reduction Reactions. Oxidation-Reduction Reactions. Oxidation-Reduction Reactions
Oxidation-Reduction Reactions Chapter 11 Electrochemistry Oxidation and Reduction Reactions An oxidation and reduction reaction occurs in both aqueous solutions and in reactions where substances are burned
More informationSupplemental data. A simple and effective cleavable linker for chemical proteomics applications
Supplemental data A simple and effective cleavable linker for chemical proteomics applications Yinliang Yang, annes ahne, Bernhard Kuster, and Steven. L. Verhelst * Figure S1 Figure S2 Figure S3 Table
More informationThermodynamics of Crystal Formation
Thermodynamics of Crystal Formation! All stable ionic crystals have negative standard enthalpies of formation, ΔH o f, and negative standard free energies of formation, ΔG o f. Na(s) + ½ Cl 2 (g) NaCl(s)
More informationMitsunobu Reaction (1934-2003)
Mitsunobu eaction (1934-2003) utline General Information: Who discovered this? What is the basic reaction? The Mechanism: What exactly happens and how? Applications: i) Variations of the method- where
More informationAP CHEMISTRY 2009 SCORING GUIDELINES (Form B)
AP CHEMISTRY 2009 SCORING GUIDELINES (Form B) Question 3 (10 points) 2 H 2 O 2 (aq) 2 H 2 O(l) + O 2 (g) The mass of an aqueous solution of H 2 O 2 is 6.951 g. The H 2 O 2 in the solution decomposes completely
More informationneutrons are present?
AP Chem Summer Assignment Worksheet #1 Atomic Structure 1. a) For the ion 39 K +, state how many electrons, how many protons, and how many 19 neutrons are present? b) Which of these particles has the smallest
More information1.- L a m e j o r o p c ió n e s c l o na r e l d i s co ( s e e x p li c a r á d es p u é s ).
PROCEDIMIENTO DE RECUPERACION Y COPIAS DE SEGURIDAD DEL CORTAFUEGOS LINUX P ar a p od e r re c u p e ra r nu e s t r o c o rt a f u e go s an t e un d es a s t r e ( r ot u r a d e l di s c o o d e l a
More informationSynthetic approach to pentacyclic quassinoids from communic acids, via ambracetal derivatives
Tetrahedron 61 (2005) 837 844 Synthetic approach to pentacyclic quassinoids from communic acids, via ambracetal derivatives E. J. Alvarez-Manzaneda, a, * J. L. Romera, a A. F. Barrero, a R. Alvarez-Manzaneda,
More informationChemical Reactions in Water Ron Robertson
Chemical Reactions in Water Ron Robertson r2 f:\files\courses\1110-20\2010 possible slides for web\waterchemtrans.doc Properties of Compounds in Water Electrolytes and nonelectrolytes Water soluble compounds
More informationChapter 3 Mass Relationships in Chemical Reactions
Chapter 3 Mass Relationships in Chemical Reactions Student: 1. An atom of bromine has a mass about four times greater than that of an atom of neon. Which choice makes the correct comparison of the relative
More informationUK ResiEMEA Version 2.0.0
The following is Fitch Ratings file layout and fields for UK mortgage pools submitted to the Fitch Ratings UK RMBS Group as of 9 September 2009. Please e-mail mortgage files to the appropriate person in
More information2. Rank the following three compounds in decreasing order of basicity. O NHCCH 3 NH 2
1. To convert a nitrile to a primary amine you must: A) hydrolyze it with water. B) oxidize it with chromic acid. C) reduce it with hydrogen or lithium aluminum hydride. D) substitute it with an alkyl
More informationEXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT
EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT Pre-Lab Questions: None. 64 I. Background Information DIPEPTIDE RESEARCH PROJECT Methods developed by organic chemists for the synthesis of biopolymers have had
More informationCUSCINETTI MONTANTE MAST ROLLERS
TIPO A - TYPE A TIPO B - TYPE B TIPO C - TYPE C TIPO BE - TYPE BE TIPO E - TYPE E TIPO AA - TYPE AA TIPO L - TYPE L TIPO F - TYPE F TIPO BT - TYPE BT TIPO BK - TYPE BK 1 TIPO N - TYPE N TIPO W- TYPE W
More informationCHEMICAL REACTIONS. Chemistry 51 Chapter 6
CHEMICAL REACTIONS A chemical reaction is a rearrangement of atoms in which some of the original bonds are broken and new bonds are formed to give different chemical structures. In a chemical reaction,
More information1. When the following equation is balanced, the coefficient of Al is. Al (s) + H 2 O (l)? Al(OH) 3 (s) + H 2 (g)
1. When the following equation is balanced, the coefficient of Al is. Al (s) + H 2 O (l)? Al(OH) (s) + H 2 (g) A) 1 B) 2 C) 4 D) 5 E) Al (s) + H 2 O (l)? Al(OH) (s) + H 2 (g) Al (s) + H 2 O (l)? Al(OH)
More informationGalvanic Cells. SCH4U7 Ms. Lorenowicz. Tuesday, December 6, 2011
Galvanic Cells SCH4U7 Ms. Lorenowicz 1 Electrochemistry Concepts 1.Redox reactions involve the transfer of electrons from one reactant to another 2.Electric current is a flow of electrons in a circuit
More informationNOTICE TO MEMBERS No. 2005 047 May 10, 2005
NOTICE TO MEMBERS No. 2005 047 May 10, 2005 SYMBOL CONVERSION LONG-TERM EQUITY OPTIONS EXPIRING IN JANUARY Bourse de Montréal Inc. (the Bourse) and Canadian Derivatives Clearing Corporation (CDCC) hereby
More informationoxidize 4-Cholesten-3-one
Isolation of Cholesterol from Egg Yolk Preparation: Bring a hard-boiled egg yolk to lab! Cholesterol (1) is a major component of cell membranes. An egg yolk contains about 200 milligrams of cholesterol,
More informationNagase s Library of Unnatural Amino Acids
agase s Library of Unnatural Amino Acids August 2012 Ver.17 agase provides unique -mono substituted and, - disubstituted unnatural amino acids which should open new avenues for designing drug candidates
More informationOXIDATION REDUCTION. Section I. Cl 2 + 2e. 2. The oxidation number of group II A is always (+) 2.
OXIDATION REDUCTION Section I Example 1: Na Example 2: 2C1 Example 3: K + + e Na + + e Cl 2 + 2e K Example 4: C1 2 + 2e 2Cl 1. The oxidation number of group I A is always (+) 1. 2. The oxidation number
More informationChapter 22 Carbonyl Alpha-Substitution Reactions
John E. McMurry www.cengage.com/chemistry/mcmurry Chapter 22 Carbonyl Alpha-Substitution Reactions The α Position The carbon next to the carbonyl group is designated as being in the α position Electrophilic
More informationCHEM 110: CHAPTER 3: STOICHIOMETRY: CALCULATIONS WITH CHEMICAL FORMULAS AND EQUATIONS
1 CHEM 110: CHAPTER 3: STOICHIOMETRY: CALCULATIONS WITH CHEMICAL FORMULAS AND EQUATIONS The Chemical Equation A chemical equation concisely shows the initial (reactants) and final (products) results of
More informationFor additional information on the program, see the current university catalog.
For information call: Tel: (818) 77-81 Fax: (818) 77-08 E-mail: chemistry.office@csun.edu Website: http://www.csun.edu/chemistry Or write: Department of Chemistry and Biochemistry California State University,
More information1. PECVD in ORGANOSILICON FED PLASMAS
F. FRACASSI Department of Chemistry, University of Bari (Italy) Plasma Solution srl SURFACE MODIFICATION OF POLYMERS AND METALS WITH LOW TEMPERATURE PLASMA OUTLINE METAL TREATMENTS 1 low pressure PECVD
More informationElectrochemistry Voltaic Cells
Electrochemistry Voltaic Cells Many chemical reactions can be classified as oxidation-reduction or redox reactions. In these reactions one species loses electrons or is oxidized while another species gains
More informationMOLARITY = (moles solute) / (vol.solution in liter units)
CHEM 101/105 Stoichiometry, as applied to Aqueous Solutions containing Ionic Solutes Lect-05 MOLES - a quantity of substance. Quantities of substances can be expressed as masses, as numbers, or as moles.
More informationWord Equations and Balancing Equations. Video Notes
Word Equations and Balancing Equations Video Notes In this lesson, you will: Use the law of conservation of mass and provide standard rules for writing and balancing equations. Write and balance equations
More informationSmall μmol Scale Synthesis of a Labeled Antimicrobial Peptide using Biotage
Application ote A098 Small μmol Scale Synthesis of a Labeled Antimicrobial Peptide Page 1 Small μmol Scale Synthesis of a Labeled Antimicrobial Peptide using Biotage Initiator+ Alstra Introduction Labeled
More informationChapter 8 - Chemical Equations and Reactions
Chapter 8 - Chemical Equations and Reactions 8-1 Describing Chemical Reactions I. Introduction A. Reactants 1. Original substances entering into a chemical rxn B. Products 1. The resulting substances from
More informationGuide to Solving Sophomore Organic Synthesis Problems
Paul Bracher Chem 30 Synthesis eview Guide to Solving Sophomore rganic Synthesis Problems Disclaimer mission of a topic on this handout does not preclude that material from appearing on the final exam.
More informationGalvanic cell and Nernst equation
Galvanic cell and Nernst equation Galvanic cell Some times called Voltaic cell Spontaneous reaction redox reaction is used to provide a voltage and an electron flow through some electrical circuit When
More informationControlling Gold Nanoparticles with Atomic Precision: Synthesis and Structure Determination
Controlling Gold Nanoparticles with Atomic Precision: Synthesis and Structure Determination Huifeng Qian Department of Chemistry, Carnegie Mellon University, USA Advisor: Prof. Rongchao Jin Background
More informationHamari Chemicals, Ltd.
amari Chemicals, Ltd. Technology for Life 1 Agenda What amari can offer your company amari s Technology The amari Advantage Core Technology unnatural amino acids and peptides; reduction; chiral technologies;
More informationFinal Exam Review. I normalize your final exam score out of 70 to a score out of 150. This score out of 150 is included in your final course total.
Final Exam Review Information Your ACS standardized final exam is a comprehensive, 70 question multiple choice (a d) test featuring material from BOTH the CHM 101 and 102 syllabi. Questions are graded
More informationSample exam questions for First exam CHM 2211
Sample exam questions for First exam CM 2211 1. The IR absorption due to the stretching of which of these carbon-hydrogen bonds occurs at the highest frequency? I II III E) V IV V 2. ow many signals would
More informationWhat is a weak hydrogen bond?
What is a weak hydrogen bond? Gautam R. Desiraju School of Chemistry University of yderabad yderabad 500 046, India gautam_desiraju@yahoo.com http://202.41.85.161/~grd/ What is a hydrogen bond? Under certain
More informationChemistry: Chemical Equations
Chemistry: Chemical Equations Write a balanced chemical equation for each word equation. Include the phase of each substance in the equation. Classify the reaction as synthesis, decomposition, single replacement,
More informationVehicle Identification Numbering System 00.03
Vehicle Identification Numbering System 00.03 IMPORTANT: See Subject 050 for the vehicle identification numbering system for vehicles built before May 1, 2000. Federal Motor Vehicle Safety Standard 115
More informationMolecules, Compounds, and Chemical Equations (Chapter 3)
Molecules, Compounds, and Chemical Equations (Chapter 3) Chemical Compounds 1. Classification of Elements and Compounds Types of Pure Substances (Figure 3.4) Elements -- made up of only one type of atom
More informationAn improved procedure for the synthesis of vinylphosphonate-linked nucleic acids
Tetrahedron Letters 41 (2000) 4513±4517 An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids Sahar Abbas and Christopher J. Hayes* The School of Chemistry, The University of
More informationMathematics Common Core Sample Questions
New York State Testing Program Mathematics Common Core Sample Questions Grade The materials contained herein are intended for use by New York State teachers. Permission is hereby granted to teachers and
More informationACE PRACTICE TEST Chapter 8, Quiz 3
ACE PRACTICE TEST Chapter 8, Quiz 3 1. Using bond energies, calculate the heat in kj for the following reaction: CH 4 + 4 F 2 CF 4 + 4 HF. Use the following bond energies: CH = 414 kj/mol, F 2 = 155 kj/mol,
More informationWriting and Balancing Chemical Equations
Name Writing and Balancing Chemical Equations Period When a substance undergoes a chemical reaction, chemical bonds are broken and new bonds are formed. This results in one or more new substances, often
More informationFORMA is EXAM I, VERSION 1 (v1) Name
FORMA is EXAM I, VERSION 1 (v1) Name 1. DO NOT TURN THIS PAGE UNTIL DIRECTED TO DO SO. 2. These tests are machine graded; therefore, be sure to use a No. 1 or 2 pencil for marking the answer sheets. 3.
More informationChem 31 Fall 2002. Chapter 3. Stoichiometry: Calculations with Chemical Formulas and Equations. Writing and Balancing Chemical Equations
Chem 31 Fall 2002 Chapter 3 Stoichiometry: Calculations with Chemical Formulas and Equations Writing and Balancing Chemical Equations 1. Write Equation in Words -you cannot write an equation unless you
More informationOxidation / Reduction Handout Chem 2 WS11
Oxidation / Reduction Handout Chem 2 WS11 The original concept of oxidation applied to reactions where there was a union with oxygen. The oxygen was either furnished by elemental oxygen or by compounds
More informationCalculations and Chemical Equations. Example: Hydrogen atomic weight = 1.008 amu Carbon atomic weight = 12.001 amu
Calculations and Chemical Equations Atomic mass: Mass of an atom of an element, expressed in atomic mass units Atomic mass unit (amu): 1.661 x 10-24 g Atomic weight: Average mass of all isotopes of a given
More information8. Relax and do well.
CHEM 1314 3:30 pm Section Exam II ohn II. Gelder October 16, 2002 Name TA's Name Lab Section INSTRUCTIONS: 1. This examination consists of a total of 8 different pages. The last three pages include a periodic
More information