Supplementary Information. Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes.

Size: px
Start display at page:

Download "Supplementary Information. Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes."

Transcription

1 This journal is (c) The Royal Society of Chemistry 8 Supplementary Information Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes. Atsushi Sato, Masanori Yoshida* and Shoji ara Division of Chemical Process Engineering, Graduate School of Engineering, okkaido University, Sapporo Japan. Fax: ; Tel: ; Contents (A) General comments (B) Materials (C) Preparation of amino acid salts (D) General procedure for the Michael addition of isobutyraldehyde with trans-β-nitroalkenes and compound characterization data of the Michael adducts (E) Preparation of L-(4-tert-butyldimethylsilyloxy)phenylalanine (F) References

2 This journal is (c) The Royal Society of Chemistry 8 (A) General comments. IR spectra were recorded using a JASCO FT/IR-53 spectrometer. NMR (4 Mz) and 3 C NMR ( Mz) spectra were recorded on JEOL JNM-A4II FT NMR and ECX-4P. Chemical shifts, δ are referred to TMS. EI and ESI high-resolution mass spectra were measured on a JEOL JMS-7TZ or JMS-TLP spectrometer. Optical rotation was measured by JASCO DIP-36. Melting points are measured by Yanagimoto micro melting point apparatus and are uncorrected. PLC was carried out using a JASCO PU-89 Plus intelligent pump and a UV-75 Plus UV detector. (B) Materials. Isobutyraldehyde was used after distillation. Nitroalkenes e, a f b and g b were prepared according to the literatures. Unless otherwise noted, other materials were purchased from commercial suppliers and were used without purification. (C) Preparation of amino acid salts Typical procedure: To a mixture of L-phenylalanine (65 mg, mmol) and MeO ( ml), lithium hydroxide monohydrate (4 mg, mmol) was added at room temperature. After stirring for over night, the solution was concentrated under reduced pressure to give L-phenylalanine lithium salt as a white powder. The obtained L-phenylalanine lithium salt, Phe-OLi, was used without further purification. L-Phenylalanine magnesium bromide salt was prepared in TF using MeMgBr as a base. Phe-OLi: ν(kbr)/cm (br), 3355, 338, 385, 384, 363, 39, 948, 849, 595, 557, 495, 454, 46, 35, 3, 54, 3, 8, 8, 939, 99, 86, 84, 86, 768, 739, 7. (D) General procedure for the Michael addition of isobutyraldehyde with trans-β-nitrostyrene and compound characterization data of the Michael adducts In a 7 ml vial, isobutyraldehyde () (44 mg, mmol) was added to a slurry of L-phenylalanine lithium salt (7. mg,. mmol), C Cl ( ml) and trans-β-nitrostyrene (a) (74.6 mg,.5 mmol) at C. After the reaction mixture was stirred for 7 h at C, saturated aqueous NaCl (.5 ml) was added to the vial and extracted with Et O (3 ml 3). The combined organic phase was dried over MgSO 4, filtered and concentrated under reduced pressure. The Michael adduct, (S)-,-dimethyl-4-nitro-3-phenylbutanal (3a), 3 was isolated by column chromatography (silica gel, hexanes/et O) in 8% yield (9.7 mg) as light yellow oil.

3 This journal is (c) The Royal Society of Chemistry 8 O Ph NO 3a The enantioselectivity was determined by PLC analysis (98%ee, DAICEL CIRALCEL OD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) = 33.5 min, t r (minor enantiomer) =.6 min). The absolute configuration was determined by comparison of the optical rotation with that of the literature. 3 [α] 6 D = 4.9 (c =., CCl 3 ), δ (CDCl 3 ). (3, s),.4 (3, s), (, m), (, m), (, m), (3, m), 9.53 (, s); δ C (CDCl 3 ) 8.7,.5, 48., 48.3, 76., 8., 8.5, 8.9, 35.3, 4.; ν(neat)/cm - 365, 334, 975, 934, 878, 8, 7, 75, 63, 555, 495, 468, 456, 435, 379, 337, 34, 6, 59, 44, 9, 3, 5, 976, 9, 883, 83, 84, 78, 75, 76, 648; [R EI-MS: Calc. for C 5 NO 3 (M):.5. Found: M +,.44]

4 This journal is (c) The Royal Society of Chemistry 8,-Dimethyl-4-nitro-3-(4-methoxyphenyl)butanal (3b) O p-meoc 6 4 * NO 3b The enantioselectivity was determined by PLC analysis (98%ee, DAICEL CIRALCEL OD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) = 35.6 min, t r (minor enantiomer) =. min). The absolute configuration was not determined. [α] 6 D = +.7 (c =., CCl 3 ), white solid, Mp C, δ (CDCl 3 ). (3, s),.3 (3, s), (, m), 3.79 (3, s), (, m), (, m), (, m), 9.53 (, s); δ C (CDCl 3 ) 8.7,.4, 47.7, 48., 55., 76.4, 3.9, 6.9, 3., 59., 4.3; ν(kbr)/cm - 976, 99, 84, 78, 75, 6, 58, 553, 56, 468, 44, 379, 9, 5, 88, 9, 8, 889, 839, 8, 747, 635; [R EI-MS: Calc. for C 3 7 NO 4 (M): Found: M +, 5.5]

5 This journal is (c) The Royal Society of Chemistry 8 (S)-,-Dimethyl-4-nitro-3-(4-bromophenyl)butanal (3c) 4 O p-brc 6 4 NO 3c The enantioselectivity was determined by PLC analysis (99%ee, DAICEL CIRALCEL OD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) = 38. min, t r (minor enantiomer) = 4. min). The absolute configuration was determined by comparison of the optical rotation with that of the literature. 4 [α] 6 D = 3.3 (c =., CCl 3 ), white solid, Mp C, δ (CDCl 3 ). (3, s),.3 (3, s), (, m), (, m), (, m), (, m), 9.5 (, s); δ C (CDCl 3 ) 8.8,.6, 47.8, 48., 75.9,., 3.6, 3.8, 34.3, 3.7; ν(kbr)/cm - 33, 973, 934, 874, 88, 78, 78, 559, 487, 468, 44, 4, 38, 35, 36, 6, 44, 3, 74, 9, 889, 845, 78, 7, 7, 664; [R EI-MS: Calc. for C 4 BrNO 3 (M ): Found: M +, 99.45]

6 This journal is (c) The Royal Society of Chemistry 8,-Dimethyl-4-nitro-3-(4-fluorophenyl)butanal (3d) O p-fc 6 4 * NO 3d The enantioselectivity was determined by PLC analysis (99%ee, DAICEL CIRALCEL OD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) = 33.9 min, t r (minor enantiomer) = 7.4 min). The absolute configuration was not determined. [α] 6 D =.5 (c =., CCl 3 ), light yellow oil, δ (CDCl 3 ). (3, s),.3 (3, s), (, m), (, m), (, m), (, m), 9.5 (, s); δ C (CDCl 3 ) 8.7,.5, 47.6, 48., 76., 5.6 (d, J.5 z), 3.5 (d, J 8. z), 3. (d, J 3.3 z), 6.3 (d, J 47. z), 3.9; ν(neat)/cm - 345, 976, 936, 878, 8, 7, 75, 65, 555, 5, 47, 437, 379, 34, 9, 65, 5, 7, 883, 843, 75, 689, 646; [R EI-MS: Calc. for C 4 FNO 3 (M): Found: M +, ]

7 This journal is (c) The Royal Society of Chemistry 8 (S)-,-Dimethyl-4-nitro-3-(furan--yl)butanal (3e) 4a O O NO 3e The enantioselectivity was determined by PLC analysis (96%ee, DAICEL CIRALPAK AD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) =.9 min, t r (minor enantiomer) = 7. min). The absolute configuration was determined by comparison of the optical rotation with that of the literature. 4a [α] 6 D = +. (c =., CCl 3 ), light yellow oil, δ (CDCl 3 ).5 (3, s),.8 (3, s), (, m), (, m), 6. (, d, J 3. z), (, m), 7.38 (, d, J.6 z), 9.5 (, s); δ C (CDCl 3 ) 9.,., 4., 48., 74.8, 9.6,.4, 4.7, 49.7, 3.4; ν(neat)/cm - 35, 33, 975, 935, 877, 8, 7, 77, 77, 556, 55, 469, 433, 377, 344, 94, 8, 48, 78, 6, 973, 95, 886, 89, 74, 7, 599; [R EI-MS: Calc. for C 3 NO 4 (M):.845. Found: M +,.853]

8 This journal is (c) The Royal Society of Chemistry 8,-Dimethyl-4-nitro-3-cyclohexylbutanal (3f) O * NO 3f The enantioselectivity was determined by PLC analysis (88%ee, DAICEL CIRALCEL OD-, 5% isopropanol/hexanes,. ml/min, nm; t r (major enantiomer) = 9.3 min, t r (minor enantiomer) = 7.6 min). The absolute configuration was not determined. [α] 6 D =.3 (c =., CCl 3 ), colorless oil, δ (CDCl 3 ).9-.9 (, m), (6, m), (, m), (, m), 9.5 (, s); δ C (CDCl 3 ) 9.,.5, 5.4, 5.9, 6.3, 9., 3.9, 38., 46.8, 48.7, 73.5, 3.9; ν(neat)/cm - 99, 855, 79, 74, 554, 449, 373, 38, 49, 3, 5, 893, 84, 76,

9 This journal is (c) The Royal Society of Chemistry 8,-Dimethyl-4-nitro-3-(-phenyleth--yl)butanal (3g) O * Ph NO 3g The enantioselectivity was determined by PLC analysis (88%ee, DAICEL CIRALPAK AD-, % isopropanol/hexanes,. ml/min, 54 nm; t r (major enantiomer) = 6. min, t r (minor enantiomer) = 7.4 min). The absolute configuration was not determined. [α] 6 D =.5 (c =., CCl 3 ), colorless oil, δ (CDCl 3 ).7 (6, s), (, m), (, m), (, m), (, m), (5, m), 9.37 (, s); δ C (CDCl 3 ) 8., 9.3, 3., 33.6, 4.6, 48.3, 76., 5.9, 7.9, 8., 4., 3.4; ν(neat)/cm - 36, 38, 97, 949, 87, 87, 7, 75, 63, 555, 496, 455, 38,, 9, 3, 885, 75, 7; [R ESI-MS: Calc. for C 4 NO 3 (M+): Found: M + +, 5.44]

10 This journal is (c) The Royal Society of Chemistry 8 (E) Preparation of L-(4-tert-butyldimethylsilyloxy)phenylalanine Cbz-Tyr-OBn was prepared by a modified procedure of Yamamoto s method 5 as following: L-Tyrosine ( g, 55 mmol), benzylalcohol (5 ml), benzene ( ml) and p-toluenesulfonic acid monohydrate (.6 g, 66 mmol) were placed in a round-bottomed flask equipped with a Dien-Stark trap. After refluxing for 7 h with an azeotropically removal of water, the reaction mixture was cooled to room temperature. A precipitated white solid was filtered, washed with Et O and dried in air. The obtained crude product was recrystallized from EtO to give a pure Tyr-OBn p-tso (.5 g, 48.5 mmol, 88%). Tyr-OBn p-tso (.9 g, 4.6 mmol) was dissolved in MeO ( ml) and cooled to C. To the mixture, Et 3 N (4.96 g, 49. mmol) and Cbz-Cl (4.9 g, 4.6 mmol) were successively added portionwise. After stirred for 8 h at C, the reaction mixture was warmed to room temperature. The resulting solution was poured into water ( ml) and extracted with Et O ( ml 3). The combined organic phase was washed with sat. aq. NaCl (5 ml), dried over MgSO 4, filtered and concentrated under reduced pressure. The obtained crude product was recrystallized from hexanes/eto (3:) to give a pure Cbz-Tyr-OBn (8.3 g, 8%). Spectroscopic data are in agreement with the published data. 5 To a mixture of Cbz-Tyr-OBn (4.5 g, mmol), DMF ( ml) and TBS-Cl (.5 g, mmol), Et 3 N (. g, mmol) was added portionwise at room temperature. After stirring for over night, the resulting solution was poured into sat. aq. N 4 Cl ( ml) and extracted with Et O (5 ml 3). The combined organic phase was washed with sat. aq. NaCl (5 ml), dried over MgSO 4, filtered and concentrated under reduced pressure. The obtained crude product was purified by column chromatography (silicagel; hexanes/et O) to give a pure O-tert-butyldimethylsilylated Cbz-Tyr-OBn (4.6 g, 89%) as a white solid. COOBn NCbz TBSO Mp C, δ (CD 3 OD). (6, s),.93 (9, s), (, m), (, m), 4.97 (, s), 5.6 (, s), 6.65 (, d, J 8.7 z), 6.96 (, d, J 8.7 z), (, m); δ C (CD 3 OD) 5.6, 7.7, 4.8, 36.5, 55.9, 66., 66.6, 9.7, 7.3, 7.6, 7.96, 8., 8., 8., 9.6, 3., 35.8, 36.8, 54.5, 57., 7.; ν(kbr)/cm - 338, 363, 336, 957, 93, 89, 859, 744, 686, 6, 543, 5, 458, 443, 39, 36, 345, 34, 63, 3, 94, 69, 5, 76, 3, 9, 986, 9, 839, 8, 78, 745, 696, 639; [R EI-MS: Calc. for C 3 37 NO 5 Si (M ): Found: M +, ].

11 This journal is (c) The Royal Society of Chemistry 8 O-tert-Butyldimethylsilylated Cbz-Tyr-OBn (.47 g,.8 mmol) and AcO (8 mg,.3 mmol) were dissolved in MeO ( ml), and the solution was added on Pd/C (%, 5 mg) under nitrogen atmosphere in a round-bottomed flask. After the atmosphere in the flask was replaced with hydrogen, the reaction mixture was stirred for 3 h under hydrogen atmosphere at room temperature. A precipitated white solid was dissolved by adding MeO, and Pd/C was filtered with Celite. The filtrate was concentrated under reduced pressure. The obtained white solid was washed with Et O and dried in air to give a pure L-(4-tert-butyldimethylsilyloxy)phenylalanine (54 mg, 66%) as an off-white solid. COO N TBSO Mp C, δ (CD 3 OD).5 (6, s),.95 (9, s), (, m), (, m), (, m), 6.77 (, d, J 8.4 z), 7.4 (, d, J 8.4 z); δ C (CD 3 OD) 5.7, 7.7, 4.8, 36., 56.3,., 8.7, 3., 54.9, 7.5; ν(kbr)/cm (br), 959, 895, 859, 6, 5, 47, 44, 4, 335, 6, 73, 7, 7, 9, 84, 88, 78, 69; [R EI-MS: Calc. for C 5 5 NO 3 Si (M): Found: M +, ].

12 This journal is (c) The Royal Society of Chemistry 8 (F) References (a) S. Y. Mahmood, M.-C. Lallemand, L. Sader-Bakaouni, O. Charton, P. Vérité,. Dufat, F. Tillequin, Tetrahedron, 4, 6, 55; (b) A. Duursma, A. J. Minnaard, B. L. Feringa, Tetrahedron,, 58, M. Yamaguchi, T. Shiraishi, M. irama, J. Org. Chem., 996, 6, (a) Y. Xu, W. Zou,. Sundén, I. Ibrahem, A. Córdova, Adv. Synth. Catal., 6, 348, 48; (b) Y. ayashi,. Gotoh, T. ayashi, M. Shoji, Angew. Chem. Int. Ed., 5, 44, 4; (c) N. Mase, R. Thayumanavan, F. Tanaka, C. F. Barbas, III, Org. Lett., 4, 6, 57; (d) M. P. Lalonde, Y. Chen, E. N. Jacobsen, Angew. Chem. Int. Ed., 6, 45, 6366; (e) S. Mossé, A. Alexakis, Org. Lett., 6, 8, (a) S.. McCooey, S. J. Connon, Org. Lett., 7, 9, 599; (b) Y. Li, X.-Y. Liu, G. Zhao, Tetrahedron: Asymmetry, 6, 7, Nakamura, M. Fujiwara, Y. Yamamoto, J. Org. Chem., 998, 63, 759.

and its application in the synthesis of Nilotinib intermediate

and its application in the synthesis of Nilotinib intermediate Electronic upplementary Material (EI) for RC Advances. This journal is The Royal ociety of Chemistry 204 upporting Information An efficient D-glucosamine-based copper catalyst for C-X couplings and its

More information

The D-glucosamine-derived pyridyl-triazole@palladium recoverable catalyst for Mizoroki-Heck reactions under solvent-free conditions

The D-glucosamine-derived pyridyl-triazole@palladium recoverable catalyst for Mizoroki-Heck reactions under solvent-free conditions Electronic Supplementary Material (ESI) for Green Chemistry. This journal is The Royal Society of Chemistry 204 Supporting Information The D-glucosamine-derived pyridyl-triazole@palladium recoverable catalyst

More information

A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information A prochelator with a modular masking group featuring hydrogen peroxide activation

More information

Supporting Information

Supporting Information Copyright WILEY VCH Verlag GmbH & Co. KGaA, 69469 Weinheim, Germany, 2012. Supporting Information for Adv. Funct. Mater., DOI: 10.1002/adfm.201102486 Colorimetric Detection of Warfare Gases by Polydiacetylenes

More information

A Simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite

A Simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite A Simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite Sabbasani Rajasekhara Reddy, a,b Anju Chadha b,c* a School of Advanced Sciences,

More information

4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol

4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol 4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol OH + HCl Cl + H 2 O C 4 H 10 O C 4 H 9 Cl (74.1) (36.5) (92.6) Classification Reaction types and substance classes nucleophilic

More information

Supporting Information

Supporting Information Supporting Information Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT Chao Wang +, Daniel Abegg +, Dominic G. Hoch, and Alexander Adibekian* ange_201511301_sm_miscellaneous_information.pdf

More information

Memory of Chirality in J-Type Aggregates of Achiral Perylene Dianhydride Dye. Created in a Chiral Asymmetric Catalytic Synthesis

Memory of Chirality in J-Type Aggregates of Achiral Perylene Dianhydride Dye. Created in a Chiral Asymmetric Catalytic Synthesis Memory of Chirality in J-Type Aggregates of Achiral Perylene Dianhydride Dye Created in a Chiral Asymmetric Catalytic Synthesis Jin-Song Zhao, Yi-Bin Ruan, Rong Zhou and Yun-Bao Jiang* Department of Chemistry,

More information

Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system

Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system Jorge C. S. da Costa, Karla C. Pais, Elisa L. Fernandes, Pedro S. M. de Oliveira, Jorge

More information

Alkoxycarbonylation of Ethylene with Cellulose in Ionic Liquids

Alkoxycarbonylation of Ethylene with Cellulose in Ionic Liquids Supplementary data Alkoxycarbonylation of Ethylene with Cellulose in Ionic Liquids Anna sichow and Stefan Mecking* Chair of Chemical Materials Science, Dept. of Chemistry, University of Konstanz, 78464

More information

Experimental procedures. Solid phase peptide synthesis (SPPS)

Experimental procedures. Solid phase peptide synthesis (SPPS) Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is The Royal Society of Chemistry 214 Experimental procedures Solid phase peptide synthesis (SPPS) Solid phase

More information

Experiment 3: Extraction: Separation of an Acidic, a Basic and a Neutral Substance

Experiment 3: Extraction: Separation of an Acidic, a Basic and a Neutral Substance 1 Experiment 3: Extraction: Separation of an Acidic, a Basic and a Neutral Substance Read pp 142-155, 161-162, Chapter 10 and pp 163-173, Chapter 11, in LTOC. View the videos: 4.2 Extraction (Macroscale);

More information

Supplementary Information for

Supplementary Information for Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2015 Supplementary Information for Doubly Responsive Polymersomes towards Monosaccharides and

More information

Acid-Base Extraction.

Acid-Base Extraction. Acid-Base Extraction. Extraction involves dissolving a compound or compounds either (1) from a solid into a solvent or (2) from a solution into another solvent. A familiar example of the first case is

More information

Working with Hazardous Chemicals

Working with Hazardous Chemicals A Publication of Reliable Methods for the Preparation of Organic Compounds Working with Hazardous Chemicals The procedures in Organic Syntheses are intended for use only by persons with proper training

More information

NATIONAL STANDARD FOR FOOD SAFETY OF THE PEOPLE S REPUBLIC OF CHINA

NATIONAL STANDARD FOR FOOD SAFETY OF THE PEOPLE S REPUBLIC OF CHINA NATIONAL STANDARD FOR FOOD SAFETY OF THE PEOPLE S REPUBLIC OF CHINA GB 5413.9 2010 National food safety standard Determination of vitamin A, D, E in foods for infants and young children, milk and milk

More information

Enantiomers: Synthesis, characterization, and resolution of tris(ethylenediamine)cobalt(iii) chloride Introduction:

Enantiomers: Synthesis, characterization, and resolution of tris(ethylenediamine)cobalt(iii) chloride Introduction: Enantiomers: Synthesis, characterization, and resolution of tris(ethylenediamine)cobalt(iii) chloride Introduction: The development of coordination chemistry prior to 1950 involved the synthesis and characterization

More information

Solid-phase Synthesis of Homodimeric Peptides: Preparation of Covalently-linked Dimers of Amyloid-beta Peptide

Solid-phase Synthesis of Homodimeric Peptides: Preparation of Covalently-linked Dimers of Amyloid-beta Peptide Electronic Supplementary Information Solid-phase Synthesis of Homodimeric Peptides: Preparation of Covalently-linked Dimers of Amyloid-beta Peptide W. Mei Kok, a,b,c Denis B. Scanlon, b John A. Karas,

More information

Separation of Active Components from Excedrin ES

Separation of Active Components from Excedrin ES Separation of Active Components from Excedrin ES Purpose: The purpose of this lab is to isolate the active components present in Exedrin ES tablets, namely acetaminophen, aspirin, and caffeine. To accomplish

More information

PURIFICATION TECHNIQUES

PURIFICATION TECHNIQUES DETERMINACIÓN DE ESTRUCTURAS ORGÁNICAS (ORGANIC SPECTROSCOPY) PURIFICATION TECHNIQUES Hermenegildo García Gómez Departamento de Química Instituto de Tecnología Química Universidad Politécnica de Valencia

More information

Precipitation Titration: Determination of Chloride by the Mohr Method by Dr. Deniz Korkmaz

Precipitation Titration: Determination of Chloride by the Mohr Method by Dr. Deniz Korkmaz Precipitation Titration: Determination of Chloride by the Mohr Method by Dr. Deniz Korkmaz Introduction Titration is a process by which the concentration of an unknown substance in solution is determined

More information

A Ratiometric NMR ph Sensing Strategy Based on Slow- Proton-Exchange (SPE) Mechanism

A Ratiometric NMR ph Sensing Strategy Based on Slow- Proton-Exchange (SPE) Mechanism Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2015 A Ratiometric NMR ph Sensing Strategy Based on Slow- Proton-Exchange (SPE) Mechanism Loïse

More information

H 2 SO 4 heat + H 3 O +

H 2 SO 4 heat + H 3 O + Dehydration of Cyclohexanol DISCUSSION OF TE EXPERIMENT In this experiment, cyclohexanol is dehydrated by aqueous sulfuric acid to produce cyclohexene as the sole product, and carbocation rearrangement

More information

CH243: Lab 4 Synthesis of Artificial Flavorings by Fischer Esterification

CH243: Lab 4 Synthesis of Artificial Flavorings by Fischer Esterification H243: Lab 4 Synthesis of Artificial Flavorings by Fischer Esterification PURPSE: To prepare esters by reaction of carboxylic acids and alcohols. To modify a known procedure to prepare an unknown. DISUSSIN:

More information

Light-driven Nanoscale Chiral Molecular Switch: Reversible Dynamic Full Range Color Phototuning

Light-driven Nanoscale Chiral Molecular Switch: Reversible Dynamic Full Range Color Phototuning This journal is (c) The Royal Society of Chemistry Supporting Information Light-driven Nanoscale Chiral Molecular Switch: Reversible Dynamic Full Range Color Phototuning Ji Ma, Yannian Li, Timothy White,

More information

Supplemental data. A simple and effective cleavable linker for chemical proteomics applications

Supplemental data. A simple and effective cleavable linker for chemical proteomics applications Supplemental data A simple and effective cleavable linker for chemical proteomics applications Yinliang Yang, annes ahne, Bernhard Kuster, and Steven. L. Verhelst * Figure S1 Figure S2 Figure S3 Table

More information

oxidize 4-Cholesten-3-one

oxidize 4-Cholesten-3-one Isolation of Cholesterol from Egg Yolk Preparation: Bring a hard-boiled egg yolk to lab! Cholesterol (1) is a major component of cell membranes. An egg yolk contains about 200 milligrams of cholesterol,

More information

EXPERIMENT 7 Reaction Stoichiometry and Percent Yield

EXPERIMENT 7 Reaction Stoichiometry and Percent Yield EXPERIMENT 7 Reaction Stoichiometry and Percent Yield INTRODUCTION Stoichiometry calculations are about calculating the amounts of substances that react and form in a chemical reaction. The word stoichiometry

More information

Diazo Coupling. A Synthesis of Methyl Orange

Diazo Coupling. A Synthesis of Methyl Orange CHEM 334L Organic Chemistry Laboratory Revision 2.0 Diazo Coupling A Synthesis of Methyl Orange In this experiment the azo dye methyl orange is prepared by a electrophilic substitution with arenediazonium

More information

Aspirin Synthesis H 3 PO 4

Aspirin Synthesis H 3 PO 4 Aspirin Synthesis Experiment 5 Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer. Salicylic acid, whose name comes from Salix, the willow

More information

Lab 4: Resolution of 1-Phenylethylamine

Lab 4: Resolution of 1-Phenylethylamine Lab 4: Resolution of 1-Phenylethylamine Reference: Ault, A. J. Chem. Educ. 1965, 42, 269. Readings: Loudon, Ch 6 esp. section 6.8 Enantiomeric Resolution (pg 224). Summary In this experiment (S)-( )-1-phenylethylamine

More information

1. COUPLING REAGENTS : Structure and acronyms

1. COUPLING REAGENTS : Structure and acronyms Coupling Reagents 1. COUPLING REAGENTS : Structure and acronyms... 2 2. CARBODIIMIDE... 3 1.a. N,N -Dicyclohexylcarbodimide (DCC)... 3 DCC/HOBt coupling experimental procedure:... 4 1.b. N-(3-Dimethylaminopropyl)-N

More information

molecules ISSN 1420-3049 www.mdpi.com/journal/molecules

molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Molecules 9, 14, 165-1613; doi:1.339/molecules144165 Article PE ACCE molecules I 142-349 www.mdpi.com/journal/molecules Preparation of Benzothiazole-ubstituted Carbosilane Dendrimers up to the 7 th Generation

More information

SYNTHETIC STUDIES ON TULEARIN MACROLIDES. M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo

SYNTHETIC STUDIES ON TULEARIN MACROLIDES. M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo SYNTHETIC STUDIES N TULEARIN MACRLIDES M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain E-mail: mmartinezc@udc.es

More information

Purification by Recrystallization

Purification by Recrystallization Experiment 2 Purification by Recrystallization Objectives 1) To be able to select an appropriate recrystallizing solvent. 2) To separate and purify acetanilide by recrystallization. 3) To compare the melting

More information

CHEM 2423 Recrystallization of Benzoic Acid EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid

CHEM 2423 Recrystallization of Benzoic Acid EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid Purpose: a) To purify samples of organic compounds that are solids at room temperature b) To dissociate the impure sample in the minimum

More information

ANALYSIS OF WATER FOR CHLORIDE AND SULFATE IONS

ANALYSIS OF WATER FOR CHLORIDE AND SULFATE IONS Test Procedure for ANALYSIS OF WATER FOR CHLORIDE AND SULFATE IONS TxDOT Designation: Tex-619-J Effective Date: August 2005 1. SCOPE 1.1 Use this method to analyze water for chloride and sulfate ions to

More information

Working with Hazardous Chemicals

Working with Hazardous Chemicals A Publication of Reliable Methods for the Preparation of Organic Compounds Working with Hazardous Chemicals The procedures in Organic Syntheses are intended for use only by persons with proper training

More information

Isolation of Caffeine from Tea

Isolation of Caffeine from Tea Isolation of Caffeine from Tea Introduction A number of interesting, biologically active compounds have been isolated from plants. Isolating some of these natural products, as they are called, can require

More information

ELECTRONIC SUPPLEMENTARY INFORMATION

ELECTRONIC SUPPLEMENTARY INFORMATION ELECTRONIC SUPPLEMENTARY INFORMATION General.. 1 1 HNMR titration fitplots.. 2 1 HNMR titration Job plots... 2 1 HNMR spectra of 1 + TBAacetate. 3 Isothermal Titration Calorimetry.. 3 High Resolution Mass

More information

Efficient Alternative Synthetic Route to Diltiazem via (2R,3S)-3-(4-Methoxyphenyl)glycidamide

Efficient Alternative Synthetic Route to Diltiazem via (2R,3S)-3-(4-Methoxyphenyl)glycidamide 146 Chem. Pharm. Bull. 47(2) 146 150 (1999) Vol. 47, No. 2 Efficient Alternative Synthetic Route to Diltiazem via (2R,3S)-3-(4-Methoxyphenyl)glycidamide Shin-ichi YAMADA, Ikuko TSUJIOKA, Takeji SHIBATANI,

More information

Marmara Üniversitesi Fen-Edebiyat Fakültesi Kimya Bölümü / Biyokimya Anabilim Dalı PURIFICATION AND CHARACTERIZATION OF PROTEINS

Marmara Üniversitesi Fen-Edebiyat Fakültesi Kimya Bölümü / Biyokimya Anabilim Dalı PURIFICATION AND CHARACTERIZATION OF PROTEINS EXPERIMENT VI PURIFICATION AND CHARACTERIZATION OF PROTEINS I- Protein isolation and dialysis In order to investigate its structure and properties a protein must be obtained in pure form. Since proteins

More information

Rapid Microwave-Assisted Solid Phase Peptide Synthesis

Rapid Microwave-Assisted Solid Phase Peptide Synthesis 592 SPECIAL TOPIC Rapid Microwave-Assisted Solid Phase Peptide Synthesis Rapid Máté Microwave-Assisted Solid Phase Peptide SynthesisErdélyi, a,b Adolf Gogoll* a a Department of Organic Chemistry, Uppsala

More information

Structure-Based Design of Covalent Siah Inhibitors

Structure-Based Design of Covalent Siah Inhibitors Chemistry & Biology, Volume 20 Supplemental Information Structure-Based Design of Covalent Siah Inhibitors John L. Stebbins, Eugenio Santelli, Yongmei Feng, Surya K. De, Angela Purves, Khatereh Motamedchaboki,

More information

experiment5 Understanding and applying the concept of limiting reagents. Learning how to perform a vacuum filtration.

experiment5 Understanding and applying the concept of limiting reagents. Learning how to perform a vacuum filtration. 81 experiment5 LECTURE AND LAB SKILLS EMPHASIZED Synthesizing an organic substance. Understanding and applying the concept of limiting reagents. Determining percent yield. Learning how to perform a vacuum

More information

Name Matter Questions Date:

Name Matter Questions Date: Name Matter Questions Date: 1. Which substance has a definite shape and a definite volume at STP? 1) NaCl(aq) 2) Cl2(g) 3) CCl4( ) 4) AlCl3(s) 2. Which two particle diagrams represent mixtures of diatornic

More information

Supporting Information

Supporting Information Supporting Information Wiley-VCH 2005 69451 Weinheim, Germany Magnetic Nanoparticle-Capped Mesoporous Silica Nanorod-Based Stimuli-Responsive Controlled Release Delivery System** Supratim Giri, Brian G.

More information

Plant Genomic DNA Extraction using CTAB

Plant Genomic DNA Extraction using CTAB Plant Genomic DNA Extraction using CTAB Introduction The search for a more efficient means of extracting DNA of both higher quality and yield has lead to the development of a variety of protocols, however

More information

12.1 Hz, 1H), 7.07-7.23 (m, 11H), 7.27-7.33 (m, 6H), 7.54 (d, J = 8.4 Hz, 2H), 10.43 (s, 1H), 13.11 (bs, 1H)

12.1 Hz, 1H), 7.07-7.23 (m, 11H), 7.27-7.33 (m, 6H), 7.54 (d, J = 8.4 Hz, 2H), 10.43 (s, 1H), 13.11 (bs, 1H) Supporting information Materials and Methods Tetraarylmethane Synthesis THF Br IIIa, b n-buli, Et 2 C Et 2, -78 o C H H Ia, b H CH Ca CH C, 90 o C, 2h aniline.hcl CH CH, toluene, Δ IVa, b IIa, b H 2 =

More information

Green Principles Atom Economy Solventless Reactions Catalysis

Green Principles Atom Economy Solventless Reactions Catalysis Lab 5: The Aldol Reaction Solventless vs Traditional Reactions: (Melting Point Study & Recrystallization) (adapted from Doxsee, K.M. and Hutchison, J.E., Green Organic Chemistry and John Thompson; Lane

More information

SUCRALOSE. White to off-white, practically odourless crystalline powder

SUCRALOSE. White to off-white, practically odourless crystalline powder SUCRALOSE Prepared at the 41st JECFA (1993), published in FNP 52 Add 2 (1993). Metals and arsenic specifications revised at the 63rd JECFA (2004). An ADI of 0-15 mg/kg bw was established at the 37th JECFA

More information

Unexpected course of a Williamson ether synthesis

Unexpected course of a Williamson ether synthesis Issue in onor of Prof. Atta-ur-Rahman ARKIVC 2007 (vii) 291-300 Unexpected course of a Williamson ether synthesis Klaus-Peter Zeller, a * Peter aiss, a Meike artmann, a and Klaus Eichele b a Institut für

More information

The Reaction of Calcium Chloride with Carbonate Salts

The Reaction of Calcium Chloride with Carbonate Salts The Reaction of Calcium Chloride with Carbonate Salts PRE-LAB ASSIGNMENT: Reading: Chapter 3 & Chapter 4, sections 1-3 in Brown, LeMay, Bursten, & Murphy. 1. What product(s) might be expected to form when

More information

ISOLATION OF CAFFEINE FROM TEA

ISOLATION OF CAFFEINE FROM TEA ISLATIN F CAFFEINE FRM TEA Introduction In this experiment, caffeine is isolated from tealeaves. The chief problem with the isolation is that caffeine does not exist alone in the tealeaves, but other natural

More information

Experiment 8 Synthesis of Aspirin

Experiment 8 Synthesis of Aspirin Experiment 8 Synthesis of Aspirin Aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs. The

More information

Synthesis and Antimicrobial Activity of 7-Amino cephalosporanic Acid Derivatives of Amino Acids and Peptides

Synthesis and Antimicrobial Activity of 7-Amino cephalosporanic Acid Derivatives of Amino Acids and Peptides Asian Journal of Chemistry Vol. 22, No. 4 (2010), 2914-2918 Synthesis and Antimicrobial Activity of 7-Amino cephalosporanic Acid Derivatives of Amino Acids and Peptides M. HIMAJA*, SIDDHARTH DESAI, A.

More information

Prepatellamide A, a new cyclic peptide from the ascidian Lissoclinum patella

Prepatellamide A, a new cyclic peptide from the ascidian Lissoclinum patella Vol. 43 No. 6 SCIENCE IN CHINA (Series B) December 2000 Prepatellamide A, a new cyclic peptide from the ascidian Lissoclinum patella FU Xiong ( ), SU Jingyu ( ) & ZENG Longmei ( ) Department of Chemistry,

More information

Tetrabutylammoniumbromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids

Tetrabutylammoniumbromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids Tetrabutylammoniumbromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids Monika Gupta a * and Basant Purnima Wakhloo b a Department of Chemistry, University of Jammu, Jammu-180

More information

TECHNICAL CHLORPYRIFOS

TECHNICAL CHLORPYRIFOS TECHNICAL WHO/SIT/21.R3 TECHNICAL CHLORPYRIFOS Full specification WHO/SIT/21.R3 Revised 10 December 1999 1. Specification 1.1 Description The material shall consist of chlorpyrifos together with related

More information

Experiment 12 Grignard Reaction; Preparation of Triphenylcarbinol

Experiment 12 Grignard Reaction; Preparation of Triphenylcarbinol Experiment 12 Grignard Reaction; Preparation of Triphenylcarbinol In this experiment we will perform a Grignard addition to an ester. First we will form the Grignard reagent from magnesium and bromobenzene

More information

Materials and Methods. Protocol for Fmoc- based solid- phase peptide synthesis

Materials and Methods. Protocol for Fmoc- based solid- phase peptide synthesis Materials and Methods All commercially available materials (Aldrich, TCI, ovabiochem, Fluka ) were used without further purification. All solvents were reagent grade or PLC grade (Fisher ). Anhydrous TF,

More information

Draw a ring around the correct answer to complete each sentence. 11. Ammonia can be reacted with an acid to produce the salt ammonium nitrate.

Draw a ring around the correct answer to complete each sentence. 11. Ammonia can be reacted with an acid to produce the salt ammonium nitrate. Q. This question is about salts of ammonia and salts of lead. (a) Ammonia dissolves in water to make an alkaline solution. Draw a ring around the correct answer to complete each sentence. The ph of a solution

More information

Coimisiún na Scrúduithe Stáit State Examinations Commission

Coimisiún na Scrúduithe Stáit State Examinations Commission Coimisiún na Scrúduithe Stáit State Examinations Commission LEAVING CERTIFICATE EXAMINATION, 2007 CHEMISTRY - ORDINARY LEVEL TUESDAY, 19 JUNE AFTERNOON 2.00 TO 5.00 400 MARKS Answer eight questions in

More information

Topic 1 National Chemistry Summary Notes. Rates of Reaction

Topic 1 National Chemistry Summary Notes. Rates of Reaction Chemical Reactions Topic 1 National Chemistry Summary Notes Rates of Reaction LI 1, 2 and 3 We know a chemical reaction has taken place when we notice one or more of the following things happening: Colour

More information

A Greener Synthesis of Creatine

A Greener Synthesis of Creatine A Greener Synthesis of Creatine Carl S Lecher 1 and Ryan J Bernhardt, 2 Marian College, Indianapolis, I Chemical Concepts Addition to nitriles, vacuum filtration, melting point determination Green Lessons

More information

Preparation of frequently used solutions

Preparation of frequently used solutions Preparation of frequently used solutions Content 1. Diluting Concentrated Acids (Last Login: 08/08/2009) 2. Indicators (Last Login: 27/07/2009) 3. Standard Buffer Solutions (Last Login: 27/07/2009) 4.

More information

Supporting Information

Supporting Information Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2013 More than Meets the Eye: Conformational Switching of a Stacked Dialkoxynaphthalene Naphthalenetetracarboxylic diimide

More information

Properties of a molecule. Absolute configuration, Cahn-Ingold Prelog. Planar, axial, topological chirality and chirality at atoms other than carbon

Properties of a molecule. Absolute configuration, Cahn-Ingold Prelog. Planar, axial, topological chirality and chirality at atoms other than carbon Key stereochemical terminology Stereochemical terminology in organic chemistry can refer to structure of a molecule or to properties of a physical sample of the molecule. It is very important to recognize

More information

Prentice Hall. Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition. High School. High School

Prentice Hall. Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition. High School. High School Prentice Hall Chemistry (Wilbraham) 2008, National Student Edition - South Carolina Teacher s Edition High School C O R R E L A T E D T O High School C-1.1 Apply established rules for significant digits,

More information

Supporting Information

Supporting Information Supporting Information Wiley-VCH 2006 69451 Weinheim, Germany Supporting information: experimental details of the synthesis of the amino-functionalized polymers and nanoparticles used Tailor-made ligands

More information

Exp t 12. Exp't 12. Thiamine Catalyzed Benzoin Condensation. Introduction

Exp t 12. Exp't 12. Thiamine Catalyzed Benzoin Condensation. Introduction Exp't 12 Exp t 12 Adapted by Jon Landis and R. Minard (Penn State Univ.) from K. L. Williamson, Macroscale and Microscale Organic Experiments, 2nd Ed. 1994, Houghton Mifflin, Boston. Revised 2/22/02 Prelaboratory

More information

CHEMICAL REACTIONS OF COPPER AND PERCENT YIELD KEY

CHEMICAL REACTIONS OF COPPER AND PERCENT YIELD KEY CHEMICAL REACTIONS OF COPPER AND PERCENT YIELD Objective To gain familiarity with basic laboratory procedures, some chemistry of a typical transition element, and the concept of percent yield. Apparatus

More information

EXAMPLE EXERCISE 4.1 Change of Physical State

EXAMPLE EXERCISE 4.1 Change of Physical State EXAMPLE EXERCISE 4.1 Change of Physical State State the term that applies to each of the following changes of physical state: (a) Snow changes from a solid to a liquid. (b) Gasoline changes from a liquid

More information

SYNTHESIS AND ANALYSIS OF A COORDINATION COMPOUND OF COPPER

SYNTHESIS AND ANALYSIS OF A COORDINATION COMPOUND OF COPPER Chemistry 111 Lab: Synthesis of a Copper Complex Page H-1 SYNTHESIS AND ANALYSIS OF A COORDINATION COMPOUND OF COPPER In this experiment you will synthesize a compound by adding NH 3 to a concentrated

More information

POLYVINYL ALCOHOL. SYNONYMS Vinyl alcohol polymer, PVOH, INS No. 1203 DEFINITION DESCRIPTION FUNCTIONAL USES CHARACTERISTICS

POLYVINYL ALCOHOL. SYNONYMS Vinyl alcohol polymer, PVOH, INS No. 1203 DEFINITION DESCRIPTION FUNCTIONAL USES CHARACTERISTICS POLYVINYL ALCOHOL Prepared at the 68 th JECFA (2007) and published in FAO JECFA Monographs 4 (2007), superseding specifications prepared at the 63 rd JECFA (2004) and published in the Combined Compendium

More information

Dipeptide Synthesis. polarized light (Figure 2).

Dipeptide Synthesis. polarized light (Figure 2). Dipeptide Synthesis + Scheme 1: Peptide synthesis without carboxyl activation + 2 Throughout your organic chemistry tenure you have been taught the underlying principles necessary to construct simple organic

More information

PECTINS. SYNONYMS INS No. 440 DEFINITION DESCRIPTION. FUNCTIONAL USES Gelling agent, thickener, stabilizer, emulsifier CHARACTERISTICS

PECTINS. SYNONYMS INS No. 440 DEFINITION DESCRIPTION. FUNCTIONAL USES Gelling agent, thickener, stabilizer, emulsifier CHARACTERISTICS PECTINS SYNONYMS INS No. 440 Prepared at the 71 st JECFA (2009) and published in FAO JECFA Monographs 7 (2009), superseding specifications prepared at the 68 th JECFA (2007) and published in FAO JECFA

More information

Review - After School Matter Name: Review - After School Matter Tuesday, April 29, 2008

Review - After School Matter Name: Review - After School Matter Tuesday, April 29, 2008 Name: Review - After School Matter Tuesday, April 29, 2008 1. Figure 1 The graph represents the relationship between temperature and time as heat was added uniformly to a substance starting at a solid

More information

EXPERIMENT 9 (Organic Chemistry II) Pahlavan - Cherif Synthesis of Aspirin - Esterification

EXPERIMENT 9 (Organic Chemistry II) Pahlavan - Cherif Synthesis of Aspirin - Esterification EXPERIMENT 9 (rganic hemistry II) Pahlavan - herif Materials Hot plate 125-mL Erlenmeyer flask Melting point capillaries Melting point apparatus Büchner funnel 400-mL beaker Stirring rod hemicals Salicylic

More information

A Novel Method of Caffeine Synthesis from Uracil

A Novel Method of Caffeine Synthesis from Uracil MARCEL DEKKER, IC. 270 MADIS AVEUE EW YRK, Y 10016 SYTHETIC CMMUICATIS Õ Vol. 33, o. 19, pp. 3291 3297, 2003 A ovel Method of Caffeine Synthesis from Uracil Matthew A. Zajac, Anthony G. Zakrzewski, Mark

More information

PREPARATION AND PROPERTIES OF A SOAP

PREPARATION AND PROPERTIES OF A SOAP (adapted from Blackburn et al., Laboratory Manual to Accompany World of Chemistry, 2 nd ed., (1996) Saunders College Publishing: Fort Worth) Purpose: To prepare a sample of soap and to examine its properties.

More information

Human serum albumin (HSA) nanoparticles stabilized with. intermolecular disulfide bonds. Supporting Information

Human serum albumin (HSA) nanoparticles stabilized with. intermolecular disulfide bonds. Supporting Information Human serum albumin (HSA) nanoparticles stabilized with intermolecular disulfide bonds Wentan Wang, Yanbin Huang*, Shufang Zhao, Ting Shao and Yi Cheng* Department of Chemical Engineering, Tsinghua University,

More information

A) HCl C) 52 g KCl in 100 g water at 80ºC A) temperature of the solution increases B) supersaturated D) low temperature and high pressure D) KClO3

A) HCl C) 52 g KCl in 100 g water at 80ºC A) temperature of the solution increases B) supersaturated D) low temperature and high pressure D) KClO3 1. Which compound becomes less soluble in water as the temperature of the solution is increased? A) HCl B) 2. The solubility of O3(s) in water increases as the A) temperature of the solution increases

More information

A Grignard reagent formed would deprotonate H of the ethyl alcohol OH.

A Grignard reagent formed would deprotonate H of the ethyl alcohol OH. 216 S11-E2 Page 2 Name Key I. (9 points) Answer in the boxes below the following questions for the Grignard reagent C 3 -Mg. (1) (2 points) Is the carbon atom associated with magnesium electrophilic or

More information

TIANquick Mini Purification Kit

TIANquick Mini Purification Kit TIANquick Mini Purification Kit For purification of PCR products, 100 bp to 20 kb www.tiangen.com TIANquick Mini Purification Kit (Spin column) Cat no. DP203 Kit Contents Contents Buffer BL Buffer PB Buffer

More information

PHYSICAL SEPARATION TECHNIQUES. Introduction

PHYSICAL SEPARATION TECHNIQUES. Introduction PHYSICAL SEPARATION TECHNIQUES Lab #2 Introduction When two or more substances, that do not react chemically, are blended together, the result is a mixture in which each component retains its individual

More information

Bioinorganic Chemistry: synthesis of an oxygen-carrying Co complex

Bioinorganic Chemistry: synthesis of an oxygen-carrying Co complex 1 Bioinorganic Chemistry: synthesis of an oxygen-carrying Co complex Naturally occurring oxygen carriers and storage proteins contain a transition metal ion to which O2 can reversibly bind, typically iron

More information

Chapter 16: Tests for ions and gases

Chapter 16: Tests for ions and gases The position of hydrogen in the reactivity series Hydrogen, although not a metal, is included in the reactivity series because it, like metals, can be displaced from aqueous solution, only this time the

More information

Supporting Information. A General Route to Very Small Polymer Particles with Controlled Microstructures

Supporting Information. A General Route to Very Small Polymer Particles with Controlled Microstructures Supporting Information A General Route to Very Small Polymer Particles with Controlled Microstructures Vincent Monteil, Peter Wehrmann, and Stefan Mecking* General considerations. All manipulations (catalyst

More information

NaHSO 4 -SiO 2 promoted synthesis of Benzimidazole derivatives

NaHSO 4 -SiO 2 promoted synthesis of Benzimidazole derivatives Available online at www.scholarsresearchlibrary.com Archives of Applied Science Research, 2012, 4 (3):1517-1521 (http://scholarsresearchlibrary.com/archive.html) ISS 0975-508X CDE (USA) AASRC9 as 4 -Si

More information

Novel Method for Solid Phase Peptide Synthesis Using Microwave Energy

Novel Method for Solid Phase Peptide Synthesis Using Microwave Energy Novel Method for Solid Phase Peptide Synthesis Using Microwave Energy Jonathan M. Collins, Michael J. Collins, Rebecca C. Steorts CEM Corporation, Matthews, NC 28106-0200, U.S.A. Presented at American

More information

Multiple Choice Questions NCERT

Multiple Choice Questions NCERT CHAPTER 3 Metals and Non-metals Multiple Choice Questions 1. Which of the following property is generally not shown by metals? (a) Electrical conduction (b) Sonorous in nature (c) Dullness (d) Ductility

More information

AP*Chemistry Solubility Equilibria

AP*Chemistry Solubility Equilibria AP*Chemistry Solubility Equilibria SOLUBILITY EQUILIBRIA (K sp, THE SOLUBILITY PRODUCT) Saturated solutions of salts are another type of chemical equilibria. Remember those solubility rules? The fine print

More information

General Chemistry Lab Experiment 4. Limiting Reactant

General Chemistry Lab Experiment 4. Limiting Reactant General Chemistry Lab Experiment 4 Limiting Reactant INTRODUCTION Two factors affect the yield of products in a chemical reaction: (1) the amounts of starting materials (reactants) and (2) the percent

More information

Page 1 of 5. Purification of Cholesterol An Oxidative Addition-Reductive Elimination Sequence

Page 1 of 5. Purification of Cholesterol An Oxidative Addition-Reductive Elimination Sequence Page 1 of 5 Purification of Cholesterol An Oxidative Addition-Reductive Elimination Sequence From your lectures sessions in CEM 2010 you have learned that elimination reactions may occur when alkyl halides

More information

EXPERIMENT Aspirin: Synthesis and NMR Analysis

EXPERIMENT Aspirin: Synthesis and NMR Analysis EXPERIMENT Aspirin: Synthesis and NMR Analysis Introduction: When salicylic acid reacts with acetic anhydride in the presence of an acid catalyst, acetylsalicylic acid, or aspirin, is produced according

More information

5 E Lesson Plan Title: Precipitates: A Clue to Chemical Reactions Grade Level and Course: 8 th Grade Physical Science Materials: Epsom salt solution

5 E Lesson Plan Title: Precipitates: A Clue to Chemical Reactions Grade Level and Course: 8 th Grade Physical Science Materials: Epsom salt solution 5 E Lesson Plan Title: Precipitates: A Clue to Chemical Reactions Grade Level and Course: 8 th Grade Physical Science Materials: Epsom salt solution Household ammonia Water 50 ml beaker Spoon to stir Balance

More information

Oxidation-Reduction Reactions

Oxidation-Reduction Reactions Oxidation-Reduction Reactions What is an Oxidation-Reduction, or Redox, reaction? Oxidation-reduction reactions, or redox reactions, are technically defined as any chemical reaction in which the oxidation

More information

SPE, LC-MS/MS Method for the Determination of Ethinyl Estradiol from Human Plasma

SPE, LC-MS/MS Method for the Determination of Ethinyl Estradiol from Human Plasma SPE, LC-MS/MS Method for the Determination of Ethinyl Estradiol from uman Plasma Krishna Rao Dara, Dr. Tushar N. Mehta, Asia Pacific Center of Excellence, Thermo Fisher Scientific, Ahmedabad, India Application

More information

EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT

EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT Pre-Lab Questions: None. 64 I. Background Information DIPEPTIDE RESEARCH PROJECT Methods developed by organic chemists for the synthesis of biopolymers have had

More information