CURRICULUM VITAE. NAME: Huang,Po-Hao OFFICE ADDRESS: EDUCATION: EMPLOYMENT RECORD: PROFFESIONAL AFFILIATIONS: 黃 柏 豪

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2 CURRICULUM VITAE NAME: Huang,Po-Hao 黃 柏 豪 OFFICE ADDRESS: China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, Taiwan, R.O.C. 中 國 醫 藥 大 學 附 設 醫 院, 內 科 部 風 溼 免 疫 科 台 灣 台 中 市 北 區 育 德 路 2 號 EDUCATION: China Medical College, College of Medicine, Taichung, Taiwan, R.O.C. No.91 Hsueh-Shih Road,Taichung, Taiwan 40402, R.O.C 台 灣 台 中 市 北 區 學 士 路 91 號 EMPLOYMENT RECORD: Resident, Department of Internal Medicine, Cheng Ching Hospital Resident, Department of Internal Medicine, Chief Resident of Rheumatology, Allergy and Immunology. Department of Internal Medicine, Attending Physician, Section of Rheumatology, Allergy and Immunology. Department of Internal Medicine, PROFFESIONAL AFFILIATIONS: 1. Rheumatism Association, R.O.C, 2. Chinese Society of Immunology, 3. The society of Internal Medicine, R.O.C. 4. Formosan Medical Association 5. Taiwan Society of Ultrasound in Medicine 6. International Society for Clinical Densitometry Certification

3 Research/Clinical trial experience Co- Investigator: 1. A phase 3, randomized, double-blind, placebo-controlled, active-controlled trial to evaluate the efficacy and safety of Celecoxib and Indomethacin in the treatment of moderate to severe acute gouty arthritis. 15/11/ /11/ A randomised, double-blind, placebo controlled, multi-centre phase II study of Atacicept in anti-tnfα-naïve patients with moderate to severely active rheumatoid arthritis and an inadequate response to methotrexate. 01/09/ /03/ A randomised, double-blind, placebo-controlled, multicentre prospective dose-finding Phase II/III study with Atacicept given subcutaneously to subjects having recently experienced a flare of systemic lupus erythematosus (SLE). 01/09/ /09/ A phase 2/3, randomized, double-blind, placebo-controlled, study to evaluate the safety and efficacy of Atacicept in subjects with Lupus nephritis in combination with mycphenolate Mofetil therapy. 15/07/ /07/ A Phase IIIB Multicenter, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Abatacept Administered Subcutaneously and Intravenously in Subjects with Rheumatoid Arthritis, Receiving Background Methotrexate, and Experiencing an Inadequate Response to Methotrexate. 15/07/ /07/ A phase 3, multi-center, randomized, double-blind, placebo-controlled, 52-week study to evaluate the efficacy and safety of Belimumab, a fully human monoclonal Anti-BLyS antibody, in subjects with SLE. 01/09/ /09/2008 Publications 1. Tsai CH, Chiang YC, Chen HT, Huang PH, Hsu HC, Tang CH. High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation. Biochim Biophys Acta Dec 26;1830(3): Huang CM, Huang PH, Chen CL, Lin YJ, Tsai CH, Huang WL, Tsai FJ. Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan. Rheumatology International Jul;32(7):2105-9

4 3. Huang CM, Huang PH, Chen CL, Wan L, Tsai CH, Liu SC, Huang WL, Tsai FJ. MBD4 gene is associated with rheumatoid arthritis in Chinese patients in Taiwan. Rheumatology International Jan;32(1): Chen TJ, Yang YF, Huang PH, Lin HH, Huang CC Permanent renal loss following tumor necrosis factor α antagonists for arthritis. Rheumatology International Jun;30(8): Po-Hao Huang, Chung-Ming Huang, Fuu-Jen Tsai. Polymorphisms of the TAP2 genes in Chinese patients withsystemic lupus erythematosus in Taiwan. Formosan Journal of Rheumatology 2008;22: Po-Hao Huang, Li-Hsueh, Huang, Chung-Ming Huang, An-Ping Huo. Primary Sjögren s syndrome complicated with pulmonary hypertension, a case report. Poster in th Annual Meeting of the Rheumatology Association, Taiwan 7. Po-Hao Huang, Li-Hsueh, Huang, Chung-Ming Huang, An-Ping Huo. Primary Sjögren s syndrome complicated with thrombocytopenia, 3 cases report. Poster in th Annual Meeting of the Rheumatology Association, Taiwan

5 Curriculum Vitae Name: Yi-Ming Chen Office: Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veteran General Hospital 1650 Taiwan Boulevard Sect. 4., Taichung, Taiwan, R.O.C TEL: ext 3354 FAX: Date of Birth: 26-September-1977 Medical Education: MD, PhDc School of Medicine, National Yang-Ming University, Taipei, Taiwan Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan 2010 Qualification: National Medical Board, Taiwan 2002 Board of Taiwan Society of Internal Medicine 2006 Board of Taiwan Society of Gerontology and Geriatrics 2007 Board of Chinese Society of Immunology 2009 Board of Rheumatology Association R.O.C ACADEMIC APPOINTMENTS: Lecturer in Clinical Medicine, National Defense Medical Center 2008 Lecturer in Internal Medicine, National Yang-Ming University 2009 Present Hospital Position: Attending Physician, Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taichung Veteran General Hospital 2009 Summary of Postgraduate Education: Resident in Internal Medicine, Taichung Veteran General Hospital Research Fellow in Geriatric Medicine, Taipei Veteran General Hospital Chief Resident in Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taichung Veteran General Hospital Honors, Prizes, Awards: Best young researcher award, Taichung Veterans General Hospital 2010 Best young researcher award, Taichung Veterans General Hospital 2011 Young research award, Taiwan Rheumatology Association 2011 Outstanding physician, Veterans Affairs Council, R.O.C Young Investigator Award, Merck Sharp & Dohme Corp. 2013