CURRICULUM VITAE ROBERTO GIACOMELLI MD, PhD

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1 CURRICULUM VITAE ROBERTO GIACOMELLI MD, PhD NAME Roberto Giacomelli TITLE Full Professor of Rheumatology, University of L Aquila, School of Medicine, L Aquila, Italy NATIONALITY Italian ADDRESS Permanent: Roma, Piazza della Unità 9, COUNTRY OF RESIDENCE Italy DATE OF BIRTH PLACE OF BIRTH Ancona/Italy Roberto Giacomelli, was born in Ancona on , graduated cum laude in the School of Medicine of the University of Rome La Sapienza on , were he also concluded his training in Internal Medicine and Clinical Immunology in He also received PhD in Experimental Immunology. Presently, he is Professor of Rheumatology and Director of the Rheumatology Clinical Unit at the University of L Aquila, School of Medicine. In the last twelve years he was always recipient of grants supported by PRIN (progetti di ricerca di interesse nazionale), Ministry of Health and Ministry of Research, for his research in the field of Scleroderma. He has 1

2 a particular interest in vascular inflammatory disease. He is a member of the Italian Society of Rheumatology, of the Italian Society of Allergy and Clinical Immunology and of the Italian Society of Stem Cell Research. He participate in numerous international scientific groups including European Scleroderma Study Group (EU), Scleroderma Clinical Trial Consortium (USA), Eular Scleroderma Trial And Research group (EUSTAR) (EU), Autologous Stem cell Transplantation International Scleroderma Trial (ASTIS TRIAL) (EU). He is a referee for several Journals in the fields of Rheumatology and Clinical Immunology and is the author of over 200 published scientific articles, reviews and book chapters. He has been involved in phase II, III, IV clinical studies according to GCP. EDUCATION 1981 Graduation in Medicine University of Rome La Sapienza,Rome, Italy 1986 Trained in Internal Medicine University of Rome La Sapienza, Rome, Italy 1989 PhD Fellowship in Pediatric Phisiopathology and Clinical Immunology University of Rome La Sapienza, Rome, Italy Clinical Assistant, Clinica Medica, University of L Aquila, School of Medicine, L Aquila, Italy 1998 Assistant Professor of Internal Medicine University of L Aquila, School of Medicine, L Aquila, Italy 2001 Associate Professor of Internal Medicine University of L Aquila, School of Medicine, L Aquila, Italy 2005 Full Professor of Reumatology University of L Aquila, School of Medicine, L Aquila, Italy Chief of Immuno-Rheumatology Clinical Unit-University Hospital, L Aquila, Italy 2

3 AFFILIATION Registration at the professional roll of Doctors-Surgeons of Rome (Italy). Member of the Italian Society of Allergy and Immunology. Member of the Italian Society of Rheumatology. Member of Italian Society of Stem Cell Research. Member of the following international scientific groups: European Scleroderma Study Group (EU) Scleroderma Clinical Trial Consortium (USA) EUlar Scleroderma Trial And Research group (EUSTAR) (EU) PEAC (ARC) Member of the scientific committee FIRA (Fondazione Italiana Ricerca sull Artrite) REFEREE FOR: J Rheumatol Annals Rheumatic Diseases Clin Exp Rheumatol Arthritis and Rheumatism Arthritis Research and Therapy Autoimmunity Reviews Rheumatology Scandinavian Journal of Rheumatology 3

4 ACADEMIC AWARDS 1989: Academic award Società Italiana di Medicina Interna 89 Congresso Nazionale (Bologna 3-6 Novembre 1988) for the paper: "Abnorme espansione dei 'Large Granular Lymphocytes': analisi fenotipica e funzionale di 1 caso" 1998 Gruppo Italiano per la Lotta alla Sclerodermia (GILS) Academic award for the studies on the pathogenesis of Systemic Sclerosis CLINICAL TRIALS Principal investigator and coordinator of phase II, III, IV clinical studies according to GCP: Rheumatoid Arthritis: WA17044 (Roche) WA17823 (Roche) WA20496 (Roche) ACTION (Bristol-Myers Squibb) ACTrace (Roche) SWITCH-RA (Roche) GO-MORE (MSD) ACT-ION (Roche) MODERATE (Pfizer) TRUST (Roche) (ANAKIN-RA and DIABETES (SOBI)) Spondyloarthritis: GO-AHEAD (MSD) 4

5 Systemic Sclerosis: NAC (AIFA) IMATINIB (AIFA) ASTIS TRIAL (CEE) DUO Registry PATHOGENETIC MECHANISMS ASSOCIATED WITH THE PROGRESSION TO DEFINITE SYSTEMIC SCLEROSIS (SSc) IN PATIENTS AFFECTED BY RAYNAUD S PHENOMENON AND ANA POSITIVITY (FIRA) RESEARCH FIELDS Impairment of angiogenesis and vasculogenesis during Systemic Sclerosis (SSc). Study of anatomical and functional integrity of endothelial monolayer in physiological conditions. Study of stem cells (Endothelial Progenitor Cells (EPCs) and Bone Marrow-derived mesenchymal stem cells) in the replacement of affected tissues in autoimmune diseases. Stem cells transplant in autoimmune diseases. Alteration in T and B cells response in autoimmune diseases. Organization of lymphoid acquired immune response in autoimmune diseases. LABORATORY Cellular cultures of T and B cells, Macrophages, Endothelial Progenitor Cells (EPCs), Bone Marrow-derived mesenchymal stem cells Mesenchymal stem cells isolation from Bone Marrow and methods of differentiation into different mature phenotypes 5

6 Flow cytometry Immunocytochemistry Immunofluorescence and immunohystochemistry Polymerase Chain Reaction (PCR), reverse-transcriptase (RT)-PCR, Real time PCR, Western Blot Genetical assessment for different polymorphisms in Rheumatic Diseases SCIENTIFIC PRODUCTION Author of more than 200 papers in national and international journals (Pubmed) 6

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