The Most Common Autoimmune Disease: Rheumatoid Arthritis. Bonita S. Libman, M.D.
|
|
- Lisa Allyson McCormick
- 8 years ago
- Views:
Transcription
1 The Most Common Autoimmune Disease: Rheumatoid Arthritis Bonita S. Libman, M.D.
2 Disclosures Two googled comics
3
4 The Normal Immune System Network of cells and proteins that work together Goal: protect against disease by fighting against infections and cancerous cells
5 Autoimmune Definition Immunitas (Latin): exempt from public service; resistant to disease Auto- (Greek): self, one s own Autoimmune: immune system acting against oneself
6 Allergy or Autoimmune? Allergy Reaction to external substance that the body would normally ignore Autoimmune Reaction to normal internal body tissues that the body would normally ignore
7 Foreign (or self) antigen How Immune System Works MHC antigenpresenting complex T cell receptor T cell Activated T cell Cytokines Antigen presenting cell Cytokine receptor B cell T cell Cell death Infected cell (or displays self antigen) Some antibodies help T cells Antibodies recognize pathogen (or self antigen) Antibodies clear the pathogen
8 Autoimmune Disease: Scope of Problem 5-8% of US population (15-24 million people), majority are female More than 80 diseases Among the top 10 common causes of death in people younger than 65 years old
9 Autoimmune Disease in USA Rheumatoid Arthritis: > 2 million Diabetes Mellitus Type I: >1.5 million Inflammatory Bowel Disease: >1.4 million
10 Systemic vs Organ Specific Systemic: multiple body tissues affected RA, SLE, Scleroderma, Myositis Organ/Tissue Specific: one tissue or organ affected Hashimoto s, Diabetes Mellitus Type I, Multiple Sclerosis, Myasthenia Gravis
11 Top 10 Autoimmune Diseases Graves Disease Rheumatoid Arthritis (1% of world s population) Hashimoto s Thyroiditis Vitiligo Diabetes Mellitus Type I Pernicious Anemia Multiple Sclerosis Glomerulonephritis Systemic Lupus Erythematosus Sjogren s Syndrome
12 Rheumatoid Arthritis History Evidence in American skeletons years ago First convincing description in 1800 by Landré-Beauvais Was RA transmitted by explorers returning to Europe from America?
13 Rheumatoid Arthritis More frequent in women (F:M = 2-3:1) Positive familial/genetic associations, especially HLA-DR4 All ages affected
14 Rheumatoid Arthritis - Symptoms Joint pain and swelling that improves with use Profound stiffness after inactivity (more than one hour) Loss of motion Others: fever, weight loss, fatigue, inflammation in other organs (eye, lung, blood cell abnormalities)
15 Rheumatoid Arthritis - Signs Joint inflammation (swelling, warmth, tenderness) Deformities Boutonnière, Swan Neck, Ulnar Deviation Rheumatoid Nodules Typical pattern of joint involvement
16 Rheumatoid Arthritis Pattern of Joint Involvement
17 Osteoarthritis Pattern of Joint Involvement
18 (Insert picture of rheumatoid hands: 2-4)
19 (Insert picture of rheumatoid hand: 2-6)
20 (Insert picture of rheumatoid feet: 2-31)
21 (Insert picture of elbow rheumatoid nodule: 2-18)
22 (Insert picture of x-ray of fingers: 2-9)
23 (Insert picture of x-ray of hands: 2-10)
24 Rheumatoid Arthritis - Pathophysiology Marked inflammation in the joint (promoted by immune cells and proteins such as TNF alpha) Proliferation (growth) of the synovium (the lining made of connective tissue that surrounds the joint) Invasion of synovium into cartilage and bone, resulting in erosions/joint damage
25 (Insert picture of knee arthroscopy: 2-43)
26 Diagnosis of RA Symptoms of joint pain, swelling and stiffness Signs of joint swelling, deformity, nodules Positive blood test for RF and/or CCP X-ray findings
27 Rheumatoid Arthritis and Rheumatoid Factor Antibody a protein produced by the immune system to help fight off infections Rheumatoid Factor an antibody directed against other antibodies Rheumatoid Factor not the cause of rheumatoid arthritis
28 Rheumatoid Arthritis and Rheumatoid Factor Some healthy people have a rheumatoid factor Many other diseases (infections, other autoimmune diseases) can produce a rheumatoid factor 20-30% of patients with rheumatoid arthritis are negative for rheumatoid factor
29 Other Laboratory Tests and RA CCP: Antibody to Cyclic Citrullinated Peptide Specific (highly diagnostic) for RA ESR: Erythrocyte Sedimentation Rate Measures inflammation in the body Elevated in many diseases (infections, cancers, other autoimmune diseases) and sometimes in healthy people CBC: Complete Blood Count Inflammation leads to anemia and elevated platelet count
30 Rheumatoid Arthritis - Treatment Principles of Treatment Education Relief of symptoms Prevention of joint damage/preservation of function Early treatment is essential
31 Rheumatoid Arthritis Treatment Adjuncts to medications Exercise to preserve muscle strength and joint flexibility Orthotics (canes, splints or other assistive devices) Joint injection (corticosteroid) Surgery for severe end-stage joint involvement
32 Rheumatoid Arthritis - Treatment NSAIDs (Non-Steroidal Anti-Inflammatory drugs) Mildly helpful for pain and swelling Do not prevent joint damage Corticosteroids More potent than NSAIDs Side effects preclude long term use Immunosuppressive/Immunomodulatory Drugs Methotrexate Biological Drugs
33 Methotrexate Best first choice for treatment of rheumatoid arthritis Helps prevent joint damage Anchor Drug Often used in combination with other drugs Well tolerated Laboratory tests must be done to monitor for side effects
34 Biological Drugs Selectively target certain parts of the immune system that promote rheumatoid arthritis Very effective Prevent joint damage
35 Foreign (or self) antigen How Immune System Works MHC antigenpresenting complex T cell receptor T cell Activated T cell Cytokines Antigen presenting cell Cytokine receptor B cell T cell Cell death Infected cell (or displays self antigen) Some antibodies help T cells Antibodies recognize pathogen (or self antigen) Antibodies clear the pathogen
36 Biological Drugs are antibodies directed at different parts of the immune system Antibody directly targeting a cytokine Antibody targeting a receptor for a cytokine Antibody blocking co-stimulation required for cell activation Antibody directly targeting a B cell
37 Targets for Biological Drugs Pro-inflammatory cytokines Tumor Necrosis Factor alpha (TNFα) Interleukin 1 (IL-1) Interleukin 6 (IL-6) B cells CD 20 (B cell marker) T cells (via co-stimulation blockade) CTLA4 (modulator of T cell activation via CD 80/86 and CD28 co-stimulatory pathway)
38 Anti-cytokine Antibody TNFα Antibody against TNFα TNFα TNFα receptor WBC
39 Anti-Cytokine receptor fusion protein TNFα receptor TNFα WBC
40 Anti-Cytokine receptor antagonist IL-1ra IL-1 receptor IL-1 WBC
41 APC = antigen presenting cell (B cell, macrophage, dendritic cell) Co-stimulatory blockade APC Co-stimulatory molecule (e.g. CD 80) MHC Antigen Co stimulatory blocker Co-stimulatory receptor (e.g. CD 28) T cell receptor T cell
42 Antibody to B cell B cell Anti-B cell antibody
43 Biological Drugs Given by injection Subcutaneous Intravenous May cause serious infections May cause other side effects: cancer, autoimmune disease Changing one part of the immune system may impact other parts of the immune system
44 Summary Autoimmunity: immune system acts against oneself Autoimmune diseases are common; RA is the most common systemic (i.e. may affect other areas besides joints) autoimmune disease Biological treatments for RA Target certain parts of the immune system Illustrate how the immune system works
45 Autoimmunity in action?
Understanding Rheumatoid Arthritis
Understanding Rheumatoid Arthritis Understanding Rheumatoid Arthritis What Is Rheumatoid Arthritis? 1,2 Rheumatoid arthritis (RA) is a chronic autoimmune disease. It causes joints to swell and can result
More informationRheumatoid Arthritis
Rheumatoid Arthritis While rheumatoid arthritis (RA) has long been feared as one of the most disabling types of arthritis, the outlook has dramatically improved for many newly diagnosed patients. Certainly
More informationRheumatoid Arthritis Information
Rheumatoid Arthritis Information Definition Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding tissues. It can also affect other organs. Alternative
More informationRheumatoid Arthritis. Disease RA Final.indd 2 15. 6. 10. 11:23
Rheumatoid Arthritis Disease RA Final.indd 2 15. 6. 10. 11:23 Understanding what to expect can help you prepare for your transition into treatment. Rheumatoid Arthritis What You Need To Know About Rheumatoid
More informationOnce the immune system is triggered, cells migrate from the blood into the joints and produce substances that cause inflammation.
HealthExchange Points For Your Joints An Arthritis Talk Howard Epstein, MD Orthopaedic & Rheumatologic Institute Rheumatic & Immunologic Disease Cleveland Clinic Beachwood Family Health & Surgery Center
More informationInformation on Rheumatoid Arthritis
Information on Rheumatoid Arthritis Table of Contents About Rheumatoid Arthritis 1 Definition 1 Signs and symptoms 1 Causes 1 Risk factors 1 Test and diagnosis 2 Treatment options 2 Lifestyle 3 References
More informationRheumatoid Arthritis
Rheumatoid Arthritis Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Autoimmune diseases are illnesses that occur when the body's tissues are mistakenly
More informationRheumatoid Arthritis www.arthritis.org.nz
Rheumatoid Arthritis www.arthritis.org.nz Did you know? RA is the second most common form of arthritis Approximately 40,000 New Zealanders have RA RA can occur at any age, but most often appears between
More informationOsteoporosis and Arthritis: Two Common but Different Conditions
and : Two Common but Different Conditions National Institutes of Health and Related Bone Diseases ~ National Resource Center 2 AMS Circle Bethesda, MD 20892 3676 Tel: 800 624 BONE or 202 223 0344 Fax:
More informationObjectives: Immunity Gone Wrong: Autoimmune Diseases in Dental Hygiene Practice
Objectives: 1) Understand the concept of self- tolerance versus non- self- tolerance. 2) Recognize systemic and oral indicators of autoimmune diseases. 3) Identify various autoimmune diseases and their
More informationX-Plain Rheumatoid Arthritis Reference Summary
X-Plain Rheumatoid Arthritis Reference Summary Introduction Rheumatoid arthritis is a fairly common joint disease that affects up to 2 million Americans. Rheumatoid arthritis is one of the most debilitating
More informationInfl ectra for rheumatoid arthritis
Infl ectra for rheumatoid arthritis Some important information to get you started with your treatment This booklet is intended only for use by patients who have been prescribed Inflectra. Introduction
More informationTREATING AUTOIMMUNE DISEASES WITH HOMEOPATHY. Dr. Stephen A. Messer, MSEd, ND, DHANP Professor and Chair of Homeopathic Medicine
TREATING AUTOIMMUNE DISEASES WITH HOMEOPATHY Dr. Stephen A. Messer, MSEd, ND, DHANP Professor and Chair of Homeopathic Medicine AUTOIMMUNE DISEASES An autoimmune disorder occurs when the body s immune
More informationA Genetic Analysis of Rheumatoid Arthritis
A Genetic Analysis of Rheumatoid Arthritis Introduction to Rheumatoid Arthritis: Classification and Diagnosis Rheumatoid arthritis is a chronic inflammatory disorder that affects mainly synovial joints.
More informationBiologic Treatments for Rheumatoid Arthritis
Biologic Treatments Rheumatoid Arthritis (also known as cytokine inhibitors, TNF inhibitors, IL 1 inhibitor, or Biologic Response Modifiers) Description Biologics are new class of drugs that have been
More informationArthritis in Children: Juvenile Rheumatoid Arthritis By Kerry V. Cooke
Reading Comprehension Read the following essay on juvenile rheumatoid arthritis. Then use the information in the text to answer the questions that follow. Arthritis in Children: Juvenile Rheumatoid Arthritis
More informationThymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.
Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against
More informationRheumatoid Arthritis. Nicole Klett,, M.D.
Rheumatoid Arthritis Nicole Klett,, M.D. Rheumatoid Arthritis Systemic Chronic Inflammatory Primarily targets the synovium of diarthrodial joints Etiology likely combination genetic and environmental Diarthrodial
More informationAutoimmune Diseases More common than you think Randall Stevens, MD
Autoimmune Diseases More common than you think Randall Stevens, MD picture placeholder Autoimmune Diseases More than 60 different disorders Autoimmune disorders (AID) diseases caused by the immune system
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE. Health Technology Appraisal
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure
More information(Intro to Arthritis with a. Arthritis) Manager of Education & Services for the Vancouver Island Region of The Arthritis Society
Arthritis 101 (Intro to Arthritis with a Focus on Rheumatoid Arthritis) by Cari Taylor by Cari Taylor Manager of Education & Services for the Vancouver Island Region of The Arthritis Society What You Will
More informationRheumatoid arthritis: an overview. Christine Pham MD
Rheumatoid arthritis: an overview Christine Pham MD RA prevalence Chronic inflammatory disease affecting approximately 0.5 1% of the general population Prevalence is higher in North America (approaching
More informationRheumatology Labs for Primary Care Providers. Robert Monger, M.D., F.A.C.P. 2015 Frontiers in Medicine
Rheumatology Labs for Primary Care Providers Robert Monger, M.D., F.A.C.P. 2015 Frontiers in Medicine Objectives Review the Indications for and Interpretation of lab testing for the following diseases:
More informationRheumatoid Arthritis www.arthritis.org.nz
Rheumatoid Arthritis www.arthritis.org.nz Did you know? Rheumatoid arthritis (RA) is the third most common form of arthritis Approximately 40,000 New Zealanders have RA RA can occur at any age, but most
More informationANIMALS FORM & FUNCTION BODY DEFENSES NONSPECIFIC DEFENSES PHYSICAL BARRIERS PHAGOCYTES. Animals Form & Function Activity #4 page 1
AP BIOLOGY ANIMALS FORM & FUNCTION ACTIVITY #4 NAME DATE HOUR BODY DEFENSES NONSPECIFIC DEFENSES PHYSICAL BARRIERS PHAGOCYTES Animals Form & Function Activity #4 page 1 INFLAMMATORY RESPONSE ANTIMICROBIAL
More informationArthritis www.patientedu.org
written by Harvard Medical School Arthritis www.patientedu.org Arthritis is the most common chronic disease in the world, and it s the leading cause of disability in the United States. There are more than
More informationA LTCI Approach to Managing Rheumatoid Arthritis
A LTCI Approach to Managing Rheumatoid Arthritis A bit of Science, a bit of Art, a lot of Perseverance... Stephen K. Holland, MD Senior Vice President & Medical Director Long Term Care Group, Inc. Long
More informationarthritis.org Rheumatoid Arthritis Understanding Symptoms, Diagnosis and Treatments
arthritis.org Rheumatoid Arthritis Understanding Symptoms, Diagnosis and Treatments About Rheumatoid Arthritis What Is Rheumatoid Arthritis? Arthritis is a general term for inflammation of the joints.
More informationRheumatology. Rheumatoid Arthritis
Rheumatology Rheumatoid Arthritis The Rheumatology service specialises in the diagnosis and treatment of diseases affecting the musculoskeletal system. Other than providing inpatient and outpatient consultation,
More informationQUESTIONS AND ANSWERS ABOUT JUVENILE RHEUMATOID ARTHRITIS
QUESTIONS AND ANSWERS ABOUT JUVENILE RHEUMATOID ARTHRITIS What Is Arthritis? Arthritis means joint inflammation, and refers to a group of diseases that cause pain, swelling, stiffness and loss of motion
More informationArthritis: An Overview. Michael McKee, MD, MPH February 23, 2012
Arthritis: An Overview Michael McKee, MD, MPH February 23, 2012 Supporters Deaf Health Talks is possible through the support of: Rochester Recreation Club for the Deaf ( REAP ) Deaf Health Community Committee
More informationDo I need a physician referral? Yes, we see patients on referral from a health care provider.
FAQS FOR OFFICE POLICIES How do I get an appointment? New appointments are made by physician referral only. Your referring health care provided will call for the appointment for you. What do I need to
More informationARTHRITIS INTRODUCTION
ARTHRITIS INTRODUCTION Arthritis is the most common disease affecting the joints. There are various forms of arthritis but the two that are the most common are osteoarthritis (OA), and rheumatoid arthritis
More informationIMMUNOPATHOGENESIS OF. Immunology Division School of Pathology NHLS & University of the Witwatersrand 082 807 2628
IMMUNOPATHOGENESIS OF RHEUMATOID ARTHRITIS Prof AA Wadee Immunology Division School of Pathology NHLS & University of the Witwatersrand 082 807 2628 Objectives Distinguish i between type III and type IV
More informationspecific B cells Humoral immunity lymphocytes antibodies B cells bone marrow Cell-mediated immunity: T cells antibodies proteins
Adaptive Immunity Chapter 17: Adaptive (specific) Immunity Bio 139 Dr. Amy Rogers Host defenses that are specific to a particular infectious agent Can be innate or genetic for humans as a group: most microbes
More informationArthritis of the Shoulder
Arthritis of the Shoulder In 2011, more than 50 million people in the United States reported that they had been diagnosed with some form of arthritis, according to the National Health Interview Survey.
More informationTAKING CARE OF YOUR RHEUMATOID ARTHRITIS
TAKING CARE OF YOUR RHEUMATOID ARTHRITIS RHEUMATOID ARTHRITIS (RA) FAST FACTS What is Rheumatoid Arthritis? Rheumatoid arthritis (RA) is a chronic disease that can affect your ability to function and be
More informationRheumatoid Arthritis
What is Rheumatoid Arthritis? Rheumatoid Arthritis (RA) is a chronic and systemic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints. Though joints
More informationArthritis and Rheumatology Clinics of Kansas Patient Education. Reactive Arthritis (ReA) / Inflammatory Bowel Disease (IBD) Arthritis
Arthritis and Rheumatology Clinics of Kansas Patient Education Reactive Arthritis (ReA) / Inflammatory Bowel Disease (IBD) Arthritis Introduction: For as long as scientists have studied rheumatic disease,
More informationRheumatoid Arthritis
Rheumatoid Arthritis Carole Callaghan Principal Pharmacist NHS Lothian Aim To update pharmacists on the current management of rheumatoid arthritis and explore ways to implement pharmaceutical care for
More informationPsoriatic Arthritis www.arthritis.org.nz
Psoriatic Arthritis www.arthritis.org.nz Did you know? Arthritis affects one in six New Zealanders over the age of 15 years. Psoriatic arthritis usually appears in people between the ages of 30 to 50.
More informationRheumatoid Arthritis. How are joints in the body designed?
Rheumatoid Arthritis How are joints in the body designed? There are more than 100 joints that connect the body s 206 bones. These joints allow us to move the way we do when we walk to work, throw a ball
More informationRHEUMATOLOGY ICD-10 CROSSWALK
RHEUMATOLOGY ICD-10 CROSSWALK ICD is revised periodically and is currently in its tenth edition and will be implemented in the United States on October 1, 2015. There is an annual minor update and three-yearly
More informationRheumatoid Arthritis: Symptoms, Causes, and Treatments of Rheumatoid Foot and Ankle
Rheumatoid arthritis is the most common form of inflammatory arthritis, affecting about two to three million Americans. Rheumatoid arthritis is a symmetric disease, meaning that it will usually involve
More informationOther Noninfectious Diseases. Chapter 31 Lesson 3
Other Noninfectious Diseases Chapter 31 Lesson 3 Diabetes Diabetes- a chronic disease that affects the way body cells convert food into energy. Diabetes is the seventh leading cause of death by disease
More informationImmune modulation in rheumatology. Geoff McColl University of Melbourne/Australian Rheumatology Association
Immune modulation in rheumatology Geoff McColl University of Melbourne/Australian Rheumatology Association A traditional start to a presentation on biological agents in rheumatic disease is Plasma cell
More informationThe ANA Test: All You Need to Know Department of Family and Community Medicine Family Medicine Update April 25, 2014
The ANA Test: All You Need to Know Department of Family and Community Medicine Family Medicine Update April 25, 2014 Celso R. Velázquez MD Division of Rheumatology University of Missouri velazquezc@health.missouri.edu
More informationF r e q u e n t l y A s k e d Q u e s t i o n s
Myasthenia Gravis Q: What is myasthenia gravis (MG)? A: Myasthenia gravis (meye-uhss- THEEN-ee-uh GRAV uhss) (MG) is an autoimmune disease that weakens the muscles. The name comes from Greek and Latin
More informationResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Research Journal of Pharmaceutical, Biological and Chemical Sciences Arthritis A Review. R Sutharsingh*, M Uvarani and P Solairaj. ABSTRACT Arthritis is a joint disorder featuring inflammation. A joint
More information.org. Arthritis of the Hand. Description
Arthritis of the Hand Page ( 1 ) The hand and wrist have multiple small joints that work together to produce motion, including the fine motion needed to thread a needle or tie a shoelace. When the joints
More informationRheumatoid Arthritis. What is rheumatoid arthritis? Understanding joints. What causes rheumatoid arthritis?
Page 1 of 6 Rheumatoid Arthritis Rheumatoid arthritis causes inflammation, pain, and swelling of joints. In time, affected joints typically become damaged. The severity can vary from mild to severe. Treatments
More informationAutoimmunity and immunemediated. FOCiS. Lecture outline
1 Autoimmunity and immunemediated inflammatory diseases Abul K. Abbas, MD UCSF FOCiS 2 Lecture outline Pathogenesis of autoimmunity: why selftolerance fails Genetics of autoimmune diseases Therapeutic
More informationElbow Injuries and Disorders
Elbow Injuries and Disorders Introduction Your elbow joint is made up of bone, cartilage, ligaments and fluid. Muscles and tendons help the elbow joint move. There are many injuries and disorders that
More informationOverview of Rheumatology
Overview of Rheumatology Clinical Services Elizabeth D. Ferucci, MD, MPH Rheumatologist Outpatient and Subspecialty Internal Medicine Department Alaska Native Tribal Health Consortium Recorded December
More informationIt is most common between the ages of 40 and 70, but can affect people of any age.
Rheumatoid arthritis Introduction Rheumatoid arthritis is a condition that causes pain and swelling in the joints. Hands, feet and wrists are commonly affected, but it can also damage other parts of the
More informationAutoimmunity. Autoimmunity. Genetic Contributions to Autoimmunity. Targets of Autoimmunity
Autoimmunity Factors predisposing an individual to autoimmune disease Mechanisms of initiation of autoimmunity Pathogenesis of particular autoimmune disease Animal models of autoimmune disease Treatment
More informationStickler Syndrome and Arthritis
Stickler Syndrome and Arthritis Arthritis Foundation Pacific Region, Nevada Office Presented by: Crystal Schulz, MPH Community Development Manager Arthritis Foundation Improving lives through leadership
More informationRheumatoid arthritis
Rheumatoid arthritis Rheumatoid arthritis Chronic multisystem disease Unknown cause Characteristic feature persistent inflammation of synovia in symmetric peripheral joints Synovial inflammation cartilage
More informationPsoriasis and Psoriatic Arthritis Alliance
Psoriasis and Psoriatic Arthritis Alliance A principal source of information on psoriasis and psoriatic arthritis ) Treatments for Psoriatic Arthritis overview Although psoriatic arthritis is a chronic
More informationCurrent Rheumatoid Arthritis Treatment Options: Update for Managed Care and Specialty Pharmacists
Current Rheumatoid Arthritis Treatment Options: Update for Managed Care and Specialty Pharmacists 1. Which of the following matches of biologic targets that contribute to rheumatoid arthritis (RA) and
More informationDAVID R. MANDEL, M.D., INC. Rheumatologist
DAVID R. MANDEL, M.D., INC. Rheumatologist 2011 NEW THERAPIES IN RHEUMATOID ARTHRITIS AND OSTEOPOROSIS CLINICAL MANIFESTATIONS Rheumatoid arthritis is a chronic systemic autoimmune disease that affects
More informationFacts About Aging and Bone Health
Facts About Aging and Bone Health A Guide to Better Understanding and Well Being with the compliments of Division of Health Services Diocese of Camden Exercise as treatment Along with medication, proper
More informationArthritis and Rheumatology. Antoni Chan MBChB, FRCP, PhD Consultant Rheumatologist Royal Berkshire NHS Foundation Trust
Antoni Chan MBChB, FRCP, PhD Consultant Rheumatologist Royal Berkshire NHS Foundation Trust Rheumatology Investigation, Diagnosis, Treatment The challenge 8 billion a year in cost 700,000 people suffering
More informationNutrition and Toxicants in Autoimmune Disease: Implications for Prevention and Treatment
Nutrition and Toxicants in Autoimmune Disease: Implications for Prevention and Treatment Collaborative on Health and the Environment June 17, 2014 Ted Schettler MD, MPH 1 Autoimmune diseases Autoimmunity
More informationMANUAL OSTEOPATHY JOINT MOBILIZATION FOR TREATMENT OF RHEUMATOID ARTHRITIS
MANUAL OSTEOPATHY JOINT MOBILIZATION FOR TREATMENT OF RHEUMATOID ARTHRITIS Student; Liu Ai Cao, RMT Investigative Project as required by National Academy of Osteopathy June 2011 Professor: Dr. Shahin Pourgol,
More informationMEDICATION GUIDE. ACTEMRA (AC-TEM-RA) (tocilizumab) Solution for Intravenous Infusion
MEDICATION GUIDE ACTEMRA (AC-TEM-RA) (tocilizumab) Solution for Intravenous Infusion ACTEMRA (AC-TEM-RA) (tocilizumab) Injection, Solution for Subcutaneous Administration Read this Medication Guide before
More informationArthroscopy of the Hand and Wrist
Arthroscopy of the Hand and Wrist Arthroscopy is a minimally invasive procedure whereby a small camera is inserted through small incisions of a few millimeters each around a joint to view the joint directly.
More informationSymptoms ongoing for 6/12, initially intermittent in nature.
Rheumatoid Arthritis Case Study INTRODUCTION Each student will have watched the relevant MDT member carrying out their initial assessment on the same newly diagnosed Rheumatoid Arthritis patient. Videos
More informationOsteoarthritis Degenerative joint disease, OA, Osteoarthrosis
Osteoarthritis Degenerative joint disease, OA, Osteoarthrosis Piedad Suarez, DDS Osteoarthritis is characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth.
More informationThe Immune System and Disease
Chapter 40 The Immune System and Disease Section 40 1 Infectious Disease (pages 1029 1033) This section describes the causes of disease and explains how infectious diseases are transmitted Introduction
More informationRheumatoid Arthritis. Treating Inflammation. Sequoia Education Systems, Inc http://www.functionalmedicineuniversity.com 1. How is RA Diagnosed?
Rheumatoid Arthritis Causes, Assessment and Treatment How is RA Diagnosed? The following labs make up the basics of ruling in or out RA. Citrullinated Peptide (anti-ccp) Antibodies Rheumatoid factor Erythrocyte
More informationStem cell treatments of rheumatoid. arthritis and the implications of. their use in treating the condition
Stem cell treatments of rheumatoid arthritis and the implications of their use in treating the condition BY Samuel House Mark Strangwood Grade awarded: Pass with Merit Research paper based on pathology
More informationLet s talk about Arthritis
Let s talk about Arthritis Osteoarthritis Rheumatoid Arthritis Kam Shojania, MD, FRCPC Clinical Professor and Head, St. Paul s, UBC and VGH Divisions of Rheumatology Slides with thanks to: Cheryl Koehn
More information3 Rd Year Medical Student Lecture Series. Rheumatology Cases. N. Lawrence Edwards, MD
3 Rd Year Medical Student Lecture Series Rheumatology Cases N. Lawrence Edwards, MD Case Study #1 32 yo WF accountant with 6 months of bilat finger and wrist pain and swelling. Morning stiffness involving
More informationBIOM 255 - Firestein, Winter 2009. Rheumatoid arthritis. Page 1
Rheumatoid arthritis Page 1 Vascular events in RA Synovium in rheumatoid arthritis Non-extra articular RA Extra articular RA Turesson, et al. Ann Rheum Dis. 2007;66:60 Normal Rheumatoid Arthritis Major
More informationLupus in Children and Teenagers. Arielle Hay, MD Pediatric Rheumatologist Nicklaus Children s Hospital
Lupus in Children and Teenagers Arielle Hay, MD Pediatric Rheumatologist Nicklaus Children s Hospital Systemic Lupus Erythematosus (SLE) Chronic Illness What is lupus? Autoimmune Multisystem Antinuclear
More informationFigure 14.2 Overview of Innate and Adaptive Immunity
I M M U N I T Y Innate (inborn) Immunity does not distinguish one pathogen from another Figure 14.2 Overview of Innate and Adaptive Immunity Our first line of defense includes physical and chemical barriers
More informationPolymyalgia Rheumatica www.arthritis.org.nz
Polymyalgia Rheumatica www.arthritis.org.nz Did you know? Arthritis affects one in six New Zealanders over the age of 15 years. Polymyalgia rheumatica is a common rheumatic condition. It affects more women
More informationThe Immune System: A Tutorial
The Immune System: A Tutorial Modeling and Simulation of Biological Systems 21-366B Shlomo Ta asan Images taken from http://rex.nci.nih.gov/behindthenews/uis/uisframe.htm http://copewithcytokines.de/ The
More informationRheumatoid Arthritis: Constantly Evolving Treatment Approaches
Rheumatoid Arthritis: Constantly Evolving Treatment Approaches Jody Garry, Pharm.D. Primary Care Pharmacy Resident VA Medical Center - Iowa City Presentation Overview Pathophysiology & epidemiology Diagnostic
More informationM05.9 Rheumatoid arthritis with rheumatoid factor, unspecified M06.00 Rheumatoid arthritis without rheumatoid factor, unspecified site M06.
Rheumatology ICD-9 ICD-10 V58.69 Z79.3 Long term (current) use of hormonal contraceptives Z79.891 Long term (current) use of opiate analgesic Z79.899 Other long term (current) drug therapy 714.0 M05.40
More informationTreatment Guide Understanding Elbow Pain. Using this Guide. Choosing Your Care. Table of Contents:
Treatment Guide Understanding Elbow Pain Elbow pain is extremely common whether due to aging, overuse, trauma or a sports injury. When elbow pain interferes with carrying the groceries, participating in
More informationFinding out your child has Juvenile Idiopathic Arthritis (JIA)
Finding out your child has Juvenile Idiopathic Arthritis (JIA) Information for parents, families and carers Jetstar Flying Start Ambassador Steve Price with Tamsin Taylor and Jennifer McNaughton Did you
More informationIt is worth noting that people with psoriasis can also develop other forms of arthritis such as rheumatoid arthritis and osteoarthritis.
Psoriatic Arthritis Main Colour - pantone 2597u Research - pantone 206u Children - pantone 123 4 What is psoriatic arthritis? Psoriatic arthritis is an inflammatory joint disease associated with psoriasis.
More informationUnderstanding How Existing and Emerging MS Therapies Work
Understanding How Existing and Emerging MS Therapies Work This is a promising and hopeful time in the field of multiple sclerosis (MS). Many new and different therapies are nearing the final stages of
More informationInformed Patient Tutorial Copyright 2012 by the American Academy of Orthopaedic Surgeons
Informed Patient Tutorial Copyright 2012 by the American Academy of Orthopaedic Surgeons Informed Patient - Carpal Tunnel Release Surgery Introduction Welcome to the American Academy of Orthopaedic Surgeons'
More informationRheumatoid Arthritis of the Foot and Ankle
Copyright 2011 American Academy of Orthopaedic Surgeons Rheumatoid Arthritis of the Foot and Ankle Rheumatoid arthritis is a chronic disease that attacks multiple joints throughout the body. It most often
More informationHealth History Form: Beverly Hosford, Muscle Activation Techniques Specialist
Health History Form: Beverly Hosford, Muscle Activation Techniques Specialist Name: Phone: Address: E-mail: Birthdate: Age: EMERGENCY CONTACT Name: Phone: Are you seeing any medical practitioners such
More informationChapter 43: The Immune System
Name Period Our students consider this chapter to be a particularly challenging and important one. Expect to work your way slowly through the first three concepts. Take particular care with Concepts 43.2
More informationSystemic Lupus Erythematosus
Harvard-MIT Division of Health Sciences and Technology HST.021: Musculoskeletal Pathophysiology, IAP 2006 Course Director: Dr. Dwight R. Robinson Systemic Lupus Erythematosus A multi-system autoimmune
More informationGoiter. This reference summary explains goiters. It covers symptoms and causes of the condition, as well as treatment options.
Goiter Introduction The thyroid gland is located at the base of your neck. If the gland becomes abnormally enlarged, it is called a goiter. Goiters usually do not cause pain. But a large goiter could cause
More informationThe word rheumatism is derived from the Greek word "rheuma," which means a swelling.
How to manage Pain & Rheumatism The word rheumatism is derived from the Greek word "rheuma," which means a swelling. It refers to an acute or chronic illness, which is characterised by pain and swelling
More informationEvaluation of Disorders of the Hands and Wrists
Evaluation of Disorders of the Hands and Wrists Case 27 yo female with 6 month history of right forearm and hand pain Works as secretary, symptoms are interfering with her job duties Complains that she
More informationRheumatoid Arthritis. Compiled by Darreck My Healing Oils notes
Rheumatoid Arthritis Compiled by Darreck My Healing Oils notes What is Rheumatoid Arthritis Rheumatoid arthritis (RA) is an autoimmune disease where the body's immune system attacks normal joint tissues,
More informationRHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE JOHNATHON DUFTON, MD
RHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE JOHNATHON DUFTON, MD RHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE ACTIVITY DESCRIPTION Rheumatoid arthritis (RA) is an inflammatory type of
More informationHow does Vectra DA measure my RA disease activity? What is Vectra DA? The more you and your doctor know about your RA, the better you can manage it
KNOW YOUR RA SCORE 65 58 50 42 40 35 29 21 15 The advanced blood test that helps you and your doctor better understand your rheumatoid arthritis (RA) disease activity with a single score 1 What is Vectra
More informationRheumatoid Arthritis
Rheumatoid Arthritis WHAT IS RHEUMATOID ARTHRITIS? Rheumatoid arthritis, or RA, is a common form of arthritis (arth means joint, itis means inflammation). RA causes inflammation in the lining of joints,
More informationThe Immune System. 2 Types of Defense Mechanisms. Lines of Defense. Line of Defense. Lines of Defense
The Immune System 2 Types of Defense Mechanisms Immune System the system that fights infection by producing cells to inactivate foreign substances to avoid infection and disease. Immunity the body s ability
More information800-475-6473. www.sjogrens.org. www.sjogrens.org
S j ö g r e n s F a s t F a c t s l The hallmark symptoms of Sjögren s syndrome are dry eyes and dry mouth. l Sjögren s is one of the most prevalent autoimmune disorders, striking as many as 4,000,000
More informationNURS 821 Alterations in the Musculoskeletal System. Rheumatoid Arthritis. Type III Hypersensitivity Response
NURS 821 Alterations in the Musculoskeletal System Margaret H. Birney PhD, RN Lecture 12 Part 2 Joint Disorders (cont d) Rheumatoid Arthritis Definition: Autoimmune disorder occurring in genetically sensitive
More information