3 rd B Cell Forum March 17 to 19, 2005 Bad Breisig, Germany Germany. Germany
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1 3 rd B Cell Forum March 17 to 19, 2005 Bad Breisig, Germany Germany Germany
2 Preliminary Program 3 rd Forum B Cell Biology Bad Breisig, March 2005 Organizing committee: Ari Waisman Markus Müschen Hans Martin Jäck Claudia Uthoff - Hachenberg all talks maximum 15 minutes plus 5 minutes discussion please hand in your powerpoint presentation at latest in the break before your session please provide powerpoint presentation on an USB-stick or a CD sorry, no personal laptops can be used for presentation
3 Thursday, 17 March :00 registration starts Chair: Markus Müschen 17:00 Roland Leathers / Invitrogen / special technical talk Advances in RNAi: Technologies and Applications 17:30 Lydia Sorokin / Lund-Sweden The Role of Extracellular Matrix in B Cell Compartmentalization in the Spleen 18:00 dinner 19:30 provisional agenda: Hans Martin Jäck / Ari Waisman report on activities election of chairperson, vice chairperson; discussion of the next meeting upcoming topics on demand 20:30 key note lecture: surprise speaker
4 Friday, 18 March :30 breakfast Late B Cell development and functions Chair: Andreas Radbruch / Nathalie Uyttersprot 09:00 Siegfried Weiss / Braunschweig Properties of B1 cells 09:20 Hermann Eibel / Freiburg BAFF-receptor deficiency in humans 09:40 Elias Hobeika / Freiburg Generation and analysis of the imb- 1 mouse Strain, with an inducible B-cell system 10:00 Ingolf Berberich / Würzburg Structure-function analysis of the Bcl-2 Family member A1 10:20 Gernot Achatz / Salzburg Isolation and characterization of proteins Interacting with the cytoplasmic tail of IgE 10:40 coffee
5 B Cell response in autoimmunity Chair: Michael Reth / Thomas Winkler 11:00 Martin Lipp / Berlin Formation of ectopic follicles in chronic Inflammatory autoimmune disorders 11:20 Siegfried Görg / Lübeck Complement,Interferon alpha and SLE 11:40 Susanna Cardell / Lund - Sweden The enlarged population of marginal zone/cd1d high B lymphocytes in non-obese diabetic mice appears before insulitis onset and maps to diabetes susceptibility region Idd11 12:00 Isis Ludwig Portugall / Bonn Investigation of autoantibody production and B cell tolerization in transgenic models 12:20 Andreas Holz / Martinsried Devic s mouse: a novel transgenic mouse model of spontaneous demyelination EAE - Role of B lymphocytes? 12:40 Ari Waisman / Köln / Mainz Are B cells tolerogenic in nature? 13:00 lunch
6 Gene conversion, hypermutation, Class Switch Chair: Ralf Küppers / Hassan Jumaa 14:30 Hiroshi Arakawa / München UNG gene disruption inactivates immunoglobulin gene conversion and activates hypermuation 14:50 Juergen Bachl / München AID expression levels and hypermutation activity correlate with the EBV-status in Burkitt s Lymphoma cell lines 15:10 Joerg Kirberg / Freiburg Increased class-switch recombination by KLF 3 overexpression despite unchanged AID transcription 15:30 Berit Jungnickel / München DNA repair in hypermutating B cells 15:50 Rolf Jessberger / Dresden SWAP-70 in B cell adhesion, migration and activation 16:10 Michael Zemlin / Marburg Antigen specific Immunoglobulin heavy chain repertoire of Peyer s Patches in mice with an altered diversity gene locus 16:10 coffee
7 Memory and Plasma Cells Chair: Juergen Wienands / Lars Nitschke 16:40 Thomas Winkler / Erlangen T cell independent activation of virus specific memory B cells 17:00 Ralf Küppers / Essen Human IgM memory B cells 17:20 Katrin Hebel / Berlin Possible dependency of plasma cells on DC In the T-independent humoral immune response 17:40 Gwendolin Muehlinghaus / Berlin Plasma cell responses and stromal microenvironments 18:00 Ayako Inamine / Berlin / Tokio Two waves of memory B cell generation in the Primary immune reponse 18:20 Christina Hausl / Vienna Mechanisms of FVIII-specific memory B cell Restimulation in murine Hemophilia A 19:30 dinner an evening to chat and discuss
8 Saturday, 19 March :30 breakfast B cell Receptor signalling Chair: Siegfried Weiss / Juergen Bachl 09:00 Mauro Togni / Magdeburg Role of the adaptor molecule SKAP-HOM in B cells 09:20 Dirk Mielenz / Erlangen Integrating Swiprosin-1 into the BCR signalling pathway 09:40 Michael Huber / Freiburg Adenosine and camp are potent inhibitors of the NFκB pathway downstream of immunoreceptors 10:00 Jürgen Wienands / Göttingen From ITAMs to Calcium 10:20 Nathalie Uyttersprot / München Signalling through Igβ and B-cell fate 10:40 Ursula Strobl / München Constitutive CD40 signalling in B cells 11:00 coffee
9 Pre B cell receptor and B cell differentiation Chair: Rolf Jessberger / Joerg Kirberg 11:30 Hassan Jumaa / Freiburg The role of adaptor proteins in pre B-cell signalling 11:50 Alexandra Schebesta / Vienna Activated and repressed Pax5 target genes in B cell development 12:10 Hans Martin Jäck / Erlangen Antibody repertoires in λ5-deficient mice A new role for surrogate light chain? 12:30 Lars Nitschke / Erlangen B cell development and B cell reponses in NFATc2/c3 -/- and Smad2 -/- mice 12:50 Markus Müschen / Düsseldorf Mimicry of a constitutively active pre-b cell receptor: Aberrant splicing links Bruton s tyrosine kinase to BCR-ABL 1 in pre-b lymphoblastic leukemia 13:10 farewell soup
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