SEILI VIRUS-CELL INTERACTIONS 2013

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1 SEILI VIRUS-CELL INTERACTIONS 2013 Archipelago Research Institute, Seili August 19-21, 2013 Program

2 General information The 8 th Seili Virus-Cell Interactions Symposium (generally known as Seili meeting ) will focus on the current and future trends in virus research including structural, biochemical, cellular and systems biological approaches, and applications within diagnostics and biomedicine Meeting Venue Seili, Nauvo, Finland ( Organizers Dr. Sisko Tauriainen (Department of Virology, University of Turku) Dr. Michaela Nygårdas (Department of Virology, University of Turku) Dr. Petri Susi (Diagnostics Group, Turku University of Applied Sciences, Turku) Supported by: Prof. Ari Helenius (ETH, Zürich, Switzerland) Prof. Kalle Saksela (University of Helsinki, Helsinki, Finland) Prof. Ari Hinkkanen (University of Eastern Finland, Kuopio, Finland) Dr. Varpu Marjomäki (University of Jyväskylä, Jyväskylä, Finland) Participants Seili Archipelago Research Institute is capable of accommodating up to 50 participants in its premises. Traditionally, the participants are the key characters in Finnish molecular and clinical virology, supported by 5-10 invited (foreign) speakers. Credits Abstracts and oral talks accepted. 1.5 ECTS for graduate students who participate actively (Faculty of Medicine, University of Turku).

3 SCIENTIFIC PROGRAM MONDAY ( ) Bus from Turku (MIKRO building) to Nauvo Arrival in Seili (boat from Nauvo harbor leaves exactly at 12.10) Keys to rooms, unloading and lunch in the Main house SESSION 1 Systems Biology, cellular interactions, receptors and entry ( ) Chair: Dr. Petri Susi Petri Susi (Turku): Opening words and practical information Ari Helenius (Zürich): Keynote lecture: Respiratory Syncytial Virus (RSV), a paramyxovirus that depends on endocytosis for entry and infection TEA & COFFEE Glyn Stanway (Colchester, UK): Heparan sulphate binding in enteroviruses Holland Cheng (Jyväskylä/Davis, USA): Conformational proteomics of macromolecular architectures Carlos Moscoso (Davis, USA): An alternative mechanism for HIV-1 viral internalization: How Tat sneaks viruses in Break Chair: Dr. Ari Hinkkanen SESSION 1 continued ( ) Renate Fuchs (Vienna): Analysis of the site of uncoating of human rhinoviruses

4 Tero Ahola (Helsinki): Mechanisms in the formation of alphavirus replication spherules Finny Varghese (Helsinki): Chikungunya virus: Replication and replication inhibitors Elina Mäntylä (Jyväskylä): Parvovirus capsid interactions with nuclear pore complex DINNER : Outdoor activities SAUNA (ladies: 19-20; gentlemen 20-, followed by makkara & kalja)

5 TUESDAY ( ) BREAKFAST Chair: Dr. Ari Helenius SESSION 2 Immunology of virus infections ( ) Malin Flodström-Tullberg (Stockholm): Host antiviral defense and viral evasion strategies during Coxsackievirus infections Ilkka Julkunen (Turku/Helsinki): Activation and inhibition of innate immunity in influenza virus infection Sanna Mäkelä (Helsinki): A novel avian influenza A (H7N9) virus induces deficient interferon responses in human dendritic cells Janne Tynell (Helsinki): MERS-CoV and human macrophage/dendritic cell interactions TEA & COFFEE SESSION 3 Systems Biology, cellular interactions ( ) Chair: Dr. Veijo Hukkanen Urs Greber (Zürich): The trafficking of viral genomes Tuula Nyman (Helsinki): Phosphoproteomic characterization of influenza A virus infected human primary macrophages Jason Mercer (Zürich): Virus-targeted RNAi screening Giuseppe Balistreri (Zürich): Comparative, 'usual suspects' sirna targeted screen to study virus entry Miika Martikainen (Kuopio): Novel oncolytic alphavirus vectors with increased tumor specificity

6 Janne Ruotsalainen (Kuopio): Subclone of resistant CT26 murine tumor shows high sensitivity to VA7 virotherapy: a novel model system to study autonomous antiviral immunity in oncolytic virotherapy LUNCH (BOAT TRIP) Chair: Dr. Ilkka Julkunen SESSION 4 Future virology ( ) Learning cafe - small group discussions followed by presentations and discussion TEA & COFFEE served during the discussions Seili Dinner SAUNA (ladies: 19-20; gentlemen 20-, followed by makkara & kalja)

7 WEDNESDAY ( ) BREAKFAST Chair: Dr. Sisko Tauriainen Wrap up session SESSION 5 Technologies and drugs ( ) Denis Kainov (Helsinki): Chemical probes for better understanding virus-host interactions Maija Vihinen-Ranta (Jyväskylä): Soft X-ray tomography analysis of virus induced changes in nuclear structures Mari Martikainen (os. Leinonen) (Jyväskylä): Site-specific targeting of enterovirus capsid by structurally precise functionalized gold nanoclusters Silke Krol (Milan): Nanoparticles as antivirals and beyond Boat from Seili to Nauvo and bus from Nauvo to Turku

8 List of partipants: Ahola Tero Airenne Kari Balistreri Giuseppe Cheng Holland Flodström-Tullberg Malin Fuchs Renate Greber Urs Helenius Ari Hinkkanen Ari Hukkanen Veijo Huttunen Moona Jiang Miao Julkunen Ilkka Kainov Denis Kakkola Laura Kamertsuk Artur Karelehto Eveliina Kolehmainen Pekka Krol Silke Latvala Sinikka Marjomäki Varpu Martikainen Miika Martikainen os. Leinonen Mari Matikainen Sampsa Mercer Jason Merilahti Pirjo Moscoso Carlos Mäkelä Sanna Mäntylä Elina Niittykoski Minna Nygårdas Michaela Nyman Tuula Paavolainen Lassi Pellicia Maria Pirhonen Jaana Ruotsalainen Janne Saksela Kalle Siponen Anu Stanway Glyn Susi Petri Tauriainen Sisko Tynell Janne Varghese Finny Waris Matti Vihinen-Ranta Maija Virtanen Jori Vähä-Koskela Markus

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