EXBIO Milestones EXBIO I Exbio Ltd. founded EXBIO Praha registered Manufacture plant in Vestec opened EXBIO I

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1 EXBIO ANTIBODIES Company with strong monoclonal antibody technology expertise Design, development and manufacture of products for flow cytometry applications

2 EXBIO I EXBIO Milestones 1990 Exbio Ltd. founded Established as spin-off company from the Institute of Molecular Genetics pioneer in technology transfer in regional biotech sector 1998 EXBIO Praha registered Research unit in Prague (6 personnel) of Exbio Ltd. transformed into independent entity 2003 Manufacture plant in Vestec opened EXBIO I 800 sq.m. research and manufacture facility 2010 Research and Technology Centre EXBIO opened- EXBIO II 2200 sq.m. facility built with support of European regional development fund (ERDF) under call POTENTIAL (Czech Ministry of Industry) EXBIO II

3 New facility EXBIO III September 2014

4 EXBIO activities EXBIO label products - Focus on Flow Cytometry - Focus on Diagnostics OEM- production Molecular Probes and other companies BULK production - antibodies for use in manufacture of diagnostics, ELISA kits, clinical studies etc. Custom Solutions - antibodies on demand for different projects for research and industrial partners

5 EXBIO label segments Clinical Immunology -Immunophenotyping (complex pannel of 2, 3, 4 and 6 color CE IVD certified combinations - Immunology kits: Phagocytosis, Allergy, Lymphocyte transformation test Clinical Hematology -Single color reagents in multiple formats for Multicolor Flow Cytometry -CD34+ FlowEx kit, ApoFlowEx Kit, CellCycleFlowEx Kit, BrdU FlowEx kit

6 EXBIO label segments Research reagents -Single color reagents in multiple formats for Multicolor Flow Cytometry -Low Endotoxin Azide Free Antibodies for functional studies -Cell Cycle Analysis Kits (PI, Annexin, BrdU) -Custom manufacture of Mabs from your own hybridoma cells -Antibody Location Service -Distribution of reagents of our bussiness partners: BioLegend, Santa Cruz, Zymo Research, Life Span BioSci, AbD Serotec, Jackson ImmunoResearch, Genetex, Abcam, Abnova and many others -

7 Our Clones MEM- clones heritage of high quality research transferred into commercial products EM- clones newly developed EXBIO clones Golden FC standard clones licenced best FC clones from whole world

8 Where We Already Flow Together Institute of Molecular Genetics, Prague MEM- clones mainly CD markers Monoclonal Antibodies against Cytokeratins, Tubulins, Signal Transduction Molecules Institute of Biotechnology, Prague Reproduction Immunology

9 Now - not only in development and licencing of clones BrdU FlowEx Kit

10 Our Dreams Let s Fly together Monday, 8:00 Delivery of BIOCEV order of antibodies to EXBIO facility Monday, 9:00 Ordered products prepared for express despatch to BIOCEV labs Monday, 10:00 Happy partners in BIOCEV Ask us for special pricing of large amounts of anti-mouse antibodies for screening, functional tests, antibody production from your own hybridomas or any other projects

11 Where to meet us in 2015? Conference Place Date Motolský Minikurz Cytometrie Prague, CZ 9 10/2 WIRM IX-9th World Immune Regulation Meeting Davos, CH 18 21/3 XIII. Martinské imunologické dni Martin, SK 25 27/3 Rumunský kurz průtokové cytometrie Bucharest, RO 20 24/4 Seminář EXBIO - 4 a více, aneb základy vicebarevné cytometrie v diagnostice Prague, CZ 13/5 BIOPOL- uzavření projektů na ÚMCH Prague, CZ 14/5 Cytoskeletální klub Vranovská ves, CZ 20 22/5 ESCCA Basic FC Course Prague, CZ 25 30/5 OHD 2015 Olomouc, CZ 31/5 2/6 EAACI 2015 Barcelona, ES 6 10/6 PhD konference ÚMG Prague, CZ 15/6 CYTO 2015 Glasgow, UK 26 30/6 Conference HLA-G 2015 Paris, FR 6 8/7 ECI 2015 Vienna, AT 6 9/9 ESCCA 2015 Giardiny Naxos, IT 30/9 3/10 Analytická cytometrie VIII Olomouc, CZ 3 6/10 ČSAKI + SSAKI 2015 Žilina, SK 21 24/10 MEDICA 2015 Dusseldorf, DE 16 19/11 Seminář EXBIO SK SK 25/11 EXBIO we support research in CZ and EUROPE!

12 EXBIO your reliable partner in research and diagnostics Price quotes, orders, technical and general information Silvie Brožová