International. Meeting on. Pulmonary. Rare Diseases. Drugs. Sergio Harari

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International Meeting on Pulmonary Rare Diseases and Orphan Drugs President Sergio Harari MilanO Italy Congress Center Palazzo delle Stelline February 25-26, 2011

President of the Congress Sergio Harari Division of Pulmonary Diseases Ospedale San Giuseppe MultiMedica Milan, Italy WITH THE PATRONAGE OF Associazione italiana pneumologi ospedalieri s.i.me.r. Società Italiana Medicina Respiratoria Scientific Secretariat Organizing Secretariat Antonella Caminati Division of Pulmonary Diseases Ospedale San Giuseppe MultiMedica Milan, Italy Victory Project Congressi Via C. Poma, 2 20129 Milan, Italy Tel. +39 02 89 05 35 24 fax +39 02 20 13 95 info@victoryproject.it www.victoryproject.it Press Office Assert Communication Via V. Monti, 41 20123 Milan, Italy Tel. +39 02 43 99 52 06 fax +39 02 43 98 52 41 info@assert.it Location Congress Center Palazzo delle Stelline Corso Magenta, 61 20123 Milan, Italy

Friday February 25, 2011 Morning Session 08.45 09.00 09.30 09.50 10.10 10.30 11.00 11.15 11.30 12.00 Welcome to the Audience New issues in the treatment of pulmonary hypertension Chairmen: Vincent Cottin (Lyon, France) Sergio Harari (Milan, Italy) Patrizio Vitulo (Palermo, Italy) Survival of ipah in the modern management era Marc Humbert (Paris, France) Upfront combination therapy in ipah Olivier Sitbon (Paris, France) The current role of phosphodiesterase type-5 inhibition in ipah and potential future development Jean Luc Vachiery (Brussels, Belgium) A role for beta adrenergic receptor blockers in the treatment of PAH Norbert Voelkel (Richmond, VA - USA) Oral prostacyclins and prostacyclin analogues Gerald Simonneau (Paris, France) Discussion Coffee break Critical issues on IPF Chairmen: Bruno Crestani (Paris, France) Cesare Saltini (Rome, Italy) Carlo Vancheri (Catania, Italy) The new evidence based ERS-ATS guidelines for the management of IPF Ulrich Costabel (Essen, Germany) Pulmonary hypertension on IPF and other interstitial lung diseases Sergio Harari (Milan, Italy) 12.30 13.00 13.15 Afternoon Session 14.30 15.00 15.20 15.40 16.00 16.20 16.50 17.10 How pathologist can help clinicians in the management of interstitial lung diseases Alberto Cavazza (Reggio Emilia, Italy) Discussion Lunch IPF: the many faces of an enigmatic disease Chairmen: Ulrich Costabel (Essen, Germany) Joel Moss (Bethesda, MD - USA) Venerino Poletti (Forlì, Italy) IPF, how to manage patients: staging, monitoring and prognostic factors Bruno Crestani (Paris, France) Genomics in IPF: wave of the future or scientific fantasy? New hypothesis in IPF pathogenesis Carlo Agostini (Padua, Italy) The ILD evaluation: detecting occult connective tissue disease Antonella Caminati (Milan, Italy) Comorbidities in idiopathic interstitial pneumonia: how to screen and follow patients Carlo Albera (Turin, Italy) Lung transplantation, pulmonary rehabilitation, oxygen and palliative care in IPF Patrizio Vitulo (Palermo, Italy) Clinical trials in the IPF therapy: what have been done and what we expect in the next future? Talmadge E. King (San Francisco, CA - USA) Discussion End of the day sessions

Saturday February 26, 2011 Morning Session 09.00 New issues in rare lung diseases (Part 1) Chairmen: Marco Confalonieri (Trieste, Italy) Loic Guillevin (Paris, France) Maurizio Luisetti (Pavia, Italy) How to detect and treat extrapulmonary sarcoidosis Dominique Valeyre (Paris, France) 12.10 12.30 13.00 13.30 Clinical insight in Pulmonary Langerhans cells hystiocitosis Olga Torre (Milan, Italy) Lymphatic involvement in Lymphangioleiomyomatosis (LAM) and Idiopathic Pulmonary Fibrosis (IPF) Joel Moss (Bethesda, MD - USA) Discussion End of the International Meeting 09.30 Pulmonary sarcoidosis: do we really know how to manage it? Alberto Pesci (Monza, Italy) 09.50 Rheumathoid arthritis and the lung: clinical manifestations and implications for treatment Vincent Cottin (Lyon, France) 10.10 Therapeutic options for lung involvement in systemic sclerosis diseases Marco Matucci Cerinic (Florence, Italy) 10.40 Discussion 11.00 Coffee break New issues in rare lung diseases (Part 2) Chairmen: Talmadge E. King (San Francisco, CA - USA) Paola Rottoli (Siena, Italy) Alessandro Sanduzzi (Naples, Italy) 11.20 An European perspective on Churg Strauss syndrome Loic Guillevin (Paris, France) 11.50 How to detect and approach extrapulmonary involvement in vasculitis Renato Alberto Sinico (Milan, Italy)

INVITED FACULTY Agostini Carlo, Padua, Italy Albera Carlo, Turin, Italy Caminati Antonella, Milan, Italy Cavazza Alberto, Reggio Emilia, Italy Confalonieri Marco, Trieste, Italy Costabel Ulrich, Essen, Germany Cottin Vincent, Lyon, France Crestani Bruno, Paris, France Guillevin Loic, Paris, France Harari Sergio, Milan, Italy Humbert Marc, Paris, France King Talmadge E., San Francisco, CA - USA Luisetti Maurizio, Pavia, Italy Matucci Cerinic Marco, Florence, Italy Moss Joel, Bethesda, MD - USA Pesci Alberto, Monza, Italy Poletti Venerino, Forlì, Italy Rottoli Paola, Siena, Italy Saltini Cesare, Rome, Italy Sanduzzi Alessandro, Naples, Italy Simonneau Gerald, Paris, France Sinico Renato Alberto, Milan, Italy Sitbon Olivier, Paris, France Torre Olga, Milan, Italy Vachiery Jean Luc, Brussels, Belgium Valeyre Dominique, Paris, France Vancheri Carlo, Catania, Italy Vitulo Patrizio, Palermo, Italy Voelkel Norbert, Richmond, VA - USA GENERAL INFORMATION

ORGANIZING SECRETARIAT Victory Project Congressi Via C. Poma 2-20129 Milan - Italy Phone: +39 02.89.05.35.24 Fax: +39 02.20.13.95 info@victoryproject.it REGISTRATION Registration prices are in Euro and include VAT AIPO SIMeR members Before December 20 290,00 After December 20 330,00 Secretariat on site Technical exhibition Certificate of attendance CME/ECM accreditation for Italian participants Language SLIDE centre Secretariat and registration desk in congress venue will be on duty on: Friday, February 25 from 08.15 to 17.30 Saturday, February 26 from 08.30 to 14.00 An exhibition of scientific and technical equipment will be organized in the Congress Area. Interested companies are kindly requested to contact the Organizing Secretariat to obtain the exhibition kit with full information. A certificate of attendance will be given to all registered participants upon presentation of their badge at the secretariat desk on Saturday, February 26. Scientific program will be submitted for Continuing Medical Education accreditation. Italian and English are the official languages of the Congress. Simultaneous translation will be available. Only pc data projection will be available during the congress. Conference room will be provided with a laptop, therefore the use of personal laptop is not allowed. To allow a smooth running of sessions, speakers are requested to contact the computer centre and hand in their cd or pen drive at least one hour before the beginning of their session. Instructions for payment Cancellations and refund Non members Before December 20 350,00 After December 20 400,00 Only registered participants are allowed to attend the scientific sessions. After February 10, 2010 only registrations on site at the New Registration Desk in the Congress Venue will be accepted. Payment of registration fee can be placed by: Bank Transfer (please enclose copy) to: Victory Project Congressi Srl UniCredit Banca - Agenzia 21903 - Milan, Italy IBAN IT58Z 02008 09403 00000 9340484 SWIFT UNCRITM1L41 For this kind of payment, participants are absolutely requested to notify the bank of their complete name and address and reason for payment. Bank expenses must be on participant s charge. Credit Card: CartaSì - Mastercard - Visa - American Express Please note that only registrations accompanied by the relevant payment will be processed. In case of cancellation of the registration, you are kindly requested to contact the Organizing Secretariat by January 10, 2010. A 70% of paid fee will be refunded. No refund will be given after this date.

HOTEL RESERVATION Hotel Instructions for hotel payment All those interested in making hotel reservation are kindly requested to send the enclosed form, by December 23, 2010, to: Victory Project Congressi Via C. Poma 2-20129 Milan - Italy Fax: +39 02.20.13.95 info@victoryproject.it Due to the great demand for hotel rooms in Milan in this period, we cannot guarantee any hotel reservation after expiration of the deadline. Palazzo Hotel delle Stelline *** Double used single 122,00 Double 132,00 Hotel King **** Double used single 350,00 Double 410,00 Hotel Milano Corso Genova *** Double used single 219,00 Double 219,00 The above listed rates are expressed in Euro and are per room per night, including continental breakfast, services and taxes. All the hotels are walking distance from the Congress Venue. The total prepayment of the requested nights and a booking fee of 25,00 per room are requested. Payment of hotel accommodation can be placed by: Bank Transfer (please enclose copy) to: Victory Project Congressi Srl UniCredit Banca - Agenzia 21903 - Milan, Italy Account n. 9340484 Swift Code UNCRIT M 1L41 IBAN IT58Z 02008 09403 00000 9340484 For this kind of payment, participants are absolutely requested to notify the bank of their complete name and address and reason for payment. Bank expenses must be on participant s charge. Cancellations and refund CONGRESS VENUE How to reach the Congress Venue Credit Card: CartaSì - Mastercard - Visa - American Express Please note that only requests accompanied by the relevant payment will be processed. No refund will be made for hotel rates. Palazzo delle Stelline Corso Magenta, 61 20123 Milan, Italy Located right in the centre of Milan and at walking distance from the S. Maria delle Grazie Church and the Castello Sforzesco fortress, the Palazzo delle Stelline was a 15th century monastery. The original building has been recently refurbished and restored through the addition of full-view windows installed in the cloister. By Plane From Malpensa Airport: take the train Malpensa Express and stop in Cadorna Station. From Linate Airport: take the bus 73 to San Babila Square and then the Underground Red Line and stop in Cadorna Station. By Train From Central Railway Station take the Underground Green Line and stop in Cadorna Station. By Car From any highway exit, follow indications Centro and then ask for piazza Cadorna. In piazza Cadorna you are at 10 minutes walking to the Congress Venue. Parking facilities are available near the Congress Venue. By Local Transportations * Underground Line 1, Red Cadorna Stop * Underground Line 2, Green Cadorna Stop * Bus: nr. 54, nr. 70, nr. 94 * Tram: nr. 19, nr. 27, nr. 29

To be sent to: VICTORY PROJECT CONGRESSI Via C. Poma 2-20129 Milano - Italy Fax + 39 02 20 13 95 info@victoryproject.it Preferably within February 10, 2011 International Meeting on Pulmonary Rare Diseases and Orphan Drugs PLEASE FILL IN THIS FORM USING A TYPEWRITER OR BLOCK LETTERS Last Name First name Address for invoice Zip Code Country Phone Mobile City E-mail registration ForM11 Institute Department C.F. / P. Iva (for Italian residents only) Registration prices are in Euro and include VAT AIPO SIMeR members Before December 20 290,00 After December 20 330,00 Non members Before December 20 350,00 After December 20 400,00

registration ForM Payments methods: Bank Transfer (please enclose copy) to: Victory Project Congressi Srl UniCredit Banca - Agenzia 21903 - Milan, Italy Account n. 9340484 - Swift Code UNCRIT M 1L41 IBAN IT58Z 02008 09403 00000 9340484 For this kind of payment, participants are absolutely requested to notify the bank of their complete name and address and the reason for the payment. Bank expenses must be on participant s charge. To be sent to: VICTORY PROJECT CONGRESSI Via C. Poma 2-20129 Milano - Italy Fax + 39 02 20 13 95 info@victoryproject.it Preferably within December 23, 2010 PLEASE FILL IN THIS FORM USING A TYPEWRITER OR BLOCK LETTERS Credit Card. Please charge my: CartaSì Mastercard Visa American Express Card nr Expiration date / Security code Cardholder s surname Cardholder s name Date of birth Date International Meeting on Pulmonary Rare Diseases and Orphan Drugs Last Name First name Address for invoice Zip Code City Country Phone Mobile E-mail C.F. / P. Iva (for Italian residents only) Signature Privacy-Italian Law n. 196/2003 We warrant complete privacy on personal data. They will be used only for communications concerning the meeting organization. HOTEL ACCOMMODATION ForM11 Palazzo Hotel delle Stelline *** Double used single 122,00 Double 132,00 Hotel King **** Double used single 350,00 Double 410,00 Hotel Milano Corso Genova *** Double used single 219,00 Double 219,00 (Prices are in Euro and are per room per night, including continental breakfast, services and taxes)

HOTEL ACCOMMODATION ForM Please reserve for me: Nr room/s double used single Preferably at Hotel Arrival date Departure date double Payments methods: Bank Transfer (please enclose copy) to: Victory Project Congressi Srl UniCredit Banca - Agenzia 21903 - Milan, Italy Account n. 9340484 - Swift Code UNCRIT M 1L41 IBAN IT58Z 02008 09403 00000 9340484 For this kind of payment, participants are absolutely requested to notify the bank of their complete name and address and the reason for the payment. Bank expenses must be on participant s charge. Credit Card. Please charge my: CartaSì Mastercard Visa American Express Card nr Expiration date / Security code Cardholder s surname Cardholder s name Date of birth Please note that only hotel requests accompanied by the relevant payment will be processed. I enclose the following amount: Hotel full payment: Booking fee of 20,00: Total Date Signature Privacy-Italian Law n. 196/2003 We warrant complete privacy on personal data. They will be used only for communications concerning the meeting organization.