Strategic Analysis of the U.S. Research Antibodies Market Presenting Opportunities for Market Share Gain March 2012
Contents Section Slide Number Executive Summary 7 Market Overview 14 Research Antibodies Market - External Challenges: Drivers and Restraints 17 Forecasts and Trends 39 Market Share and Competitive Analysis 49 The Last Word (Conclusions and Implications) 67 Appendix 77 3
List of Figures Figure Slide Number Research Antibodies Market: Market Drivers and its Impact, United States, 2012 2016 19 Research Antibodies Market: Premium Pricing for Custom Antibody Development, Global, 2012 30 Research Antibodies Market: Market Restraints and its Impact, United States, 2012 2016 31 Research Antibodies Market: Importance of Price in Antibodies Purchasing, Global, 2011 2012 34 ARRA Instrumentation Grant Funding for Mass Spectrometry, United States, 2009 2010 35 Top 10 Major Technology Groups Funded by ARRA Instrumentation Grants, United States, 2009 2010 36 Research Antibodies Market: Ranking of Challenges, Global, 2012 37 Research Antibodies Market: Premium Pricing Antibody Features, Global, 2012 38 Research Antibodies Market: Company Market Share Analysis of Top 10 Participants, United States, 2011 51 Research Antibodies Market: Competitive Structure, United States, 2011 53 Research Antibodies Market: Key Competitive Factors by Importance, Global, 2011 64 4
List of Figures (continued) Figure Slide Number Research Antibodies Market: Top Suppliers Selected by Researchers, Global, 2012 65 66 Research Antibodies Market: Customers Overall Experience by Supplier, Global, 2012 69 70 Research Antibodies Market: Reasons to Switch Antibody Suppliers, Global, 2012 75 5
List of Charts Chart Slide Number Research Antibodies Market: Market Engineering Measurements, United States, 2011 11 Research Antibodies Market: Geographic Segmentation, Global, 2011 15 Research Antibodies Market: Key Market Drivers and Restraints, United States, 2012 2016 National Institutes of Health Total Program Level Budget, United States, 2000 2013 33 Research Antibodies Market: Market Engineering Measurements, Unites States, 2011 40 Research Antibodies Market: Revenue Forecast, United States, 2009 2016 42 Selected Antibody Based Technologies Revenue Forecast, United States, 2007 2014 Research Antibodies Market: Applications Performed by Researchers Global, 2011 2012 Research Antibodies Market: Company Market Share Analysis, United States, 2011 50 Research Antibodies Market: Competitor Growth Analysis, United States, 2011 57 Research Antibodies Market: Antibody Supplier Usage, United States, 2012 58 Research Antibodies Market: Research Areas, Global, 2012 71 18 46 48 6
Drivers and Restraints Research Antibodies Market: Key Market Drivers and Restraints, United States, 2012 2016 1 2 Years 3 4 Years 5 Years Market Drivers High-growth antibody-based technologies increase demand Epigenetics field spurs new product development and market growth Continued need for basic-protein research maintains demand for antibodies Custom antibody production earns premium pricing Market Restraints Customer concerns about antibody quality may limit usage Downward pricing pressure limits market size potential Migration to competing technology mass spectrometry reduces demand Budget constraints in academic sector curbs spending Impact: High Medium Low Source: Frost & Sullivan analysis. 18
Drivers Impact and Duration Research Antibodies Market: Market Drivers and its Impact, United States, 2012 2016 Drivers 1 2 Years 3 4 Years 5 Years High-growth antibody-based technologies increase demand M Epigenetics field spurs new product development and market growth Continued need for basic-protein research maintains demand for antibodies M Custom antibody production earns premium pricing L Impact Ratings: H = High, M = Medium, L = Low Source: Frost & Sullivan analysis. 19
Drivers Explained High-growth Antibody-based Technologies Increase Demand Flow cytometry has gained tremendous popularity during the last decade. This technology measures and analyzes the physical characteristics of cells as they flow in fluid stream through a beam of light. A 2008 Frost & Sullivan analysis on the U.S. flow cytometry markets determined that the instruments market targeted to research laboratories was growing at a CAGR of xx.x percent from 2007 to 2014. Market leaders in flow cytometry instrumentation, BD Biosciences, and Beckman Coulter, Inc. also specialize in flow-grade antibodies. Due to its market-share stronghold of roughly two-thirds of the flow cytometry instrumentation market, BD Biosciences has built the most trusted and popular brand name for this technology. This reputation translates to antibodies used for flow cytometry, where BD Biosciences holds market leadership. Overall, antibody suppliers continue to expand their portfolios of multicolor flow cytometry antibodies to take advantage of the growing flow cytometry market. Source: Frost & Sullivan analysis. 20
Drivers Explained (continued) High-growth Antibody-based Technologies Increase Demand (continued) Researchers use antibodies for various applications within a wide range of research fields. Technologies requiring antibodies include: o Western blots o ELISAs o Chromatin immunoprecipitation (ChIP) o Flow cytometry, functional assays o Eectron microscopy o Fluorescence microscopy o Gel-shift assays o Immunohistochemistry (IHC) o Immunocytochemistry o Immunodiffusion o Immunofluorescence o Microarrays o Multiplex assays o Radioimmunoassays These technologies vary by age, popularity, ease of use, expense, throughput, and data output. Therefore, usage of these techniques varies greatly and contributes to market growth differently. Source: Frost & Sullivan analysis. 21
Drivers Explained (continued) High-growth Antibody-based Technologies Increase Demand (continued) A 2008 Frost & Sullivan analysis on the U.S. Research ELISA Market determined this mature market is declining at a CAGR of x.x percent from 2007 to 2014. Researchers continue to switch to multiplex-assay technologies, such as those by Luminex Corporation or Meso Scale Diagnostics, LLC, more often than they are switching to single-analyte approaches, like ELISA. While ELISA usage is declining, this trend actually contributes to market growth for antibodies as researchers perform higher-throughput reactions with a greater number of antibodies. Nevertheless, there will always be a place in research for this entrenched, trusted technology. In 2008, R&D Systems held market leadership for research ELISAs, including kits and development components, with roughly a xx-percent share. The firm s strong reputation for ELISAs likely attracts customers searching for antibodies to use in homebrew ELISA development. Overall, many research antibody suppliers also provide ELISAs. Customers performing ELISAs maybe be more likely to purchase antibody pairs from trusted ELISA kit providers. Source: Frost & Sullivan analysis. 22