Your Partner in Antibody Development Product and Service Catalog
ABOUT US QUALITY ASSURANCE Maine Biotechnology Services, Inc. (MBS) is an industry leader in antibody discovery, development and production. Services provided at MBS include bacterial recombinant production, monoclonal and polyclonal antibody development, and antibody production via mouse ascites or in vitro technology. Post-processing services offered include antibody purification, characterization and assay development. MBS has been privately owned and operated in New England since 1990, and our customers can count on the stability and longevity of our organization. We continue to utilize our experience and proprietary protocols to meet the continually evolving needs of diagnostic and pharmaceutical companies. Most recently, we have partnered with pharmaceutical companies in their quest to meet regulatory assay requirements for monitoring novel therapeutics, often through the development of anti-idiotypic antibodies. Regardless of the application, MBS maintains customer service and communication as our paramount priorities. All products manufactured at MBS comply with cgmp quality standards and Regulation (EU) 142/2011. Compliance with this regulation allows MBS products to be shipped into European Union countries. MBS manufactures antibodies that are used in commercially available immunoassay procedures. MBS is committed to production, purification and antibody testing that meets Quality System Regulations (QSR). Our facility has been reviewed and approved by the Office for Laboratory Animal Welfare (OLAW), located at the National Institutes of Health, in compliance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals. All protocols are IACUC reviewed. PRODUCT DEVELOPMENT MBS applies innovative hybridoma development tools to in-house development of new antibody products, available in bulk to researchers and IVD manufacturers. In recent years, we have significantly increased our R&D facilities in an effort to offer a growing catalog of quality antibodies with the best possible technical collateral and price flexibility critical for our diagnostic customers. If you do not find the product you are looking for, please contact us to discuss collaborative development options. MBS is particularly interested in expanding our product offering in the areas of infectious disease, food/water safety, drug development tools, veterinary targets and controls. Your Partner in Antibody Discovery
MAB= Mouse Monoclonal Antibody MAB604P Adenovirus MAB605P Adenovirus MAB742P Adenovirus MAB302P Borrelia burgdorferi (Osp A) MAB305P Borrelia burgdorferi (Osp A, p22) MAB306P Borrelia burgdorferi (Osp B, p19) MAB746P Borrelia burgdorferi (Osp B) MAB840P Campylobacter jejuni MAB841P Campylobacter jejuni MAB842P Campylobacter jejuni MAB765P Candida albicans MAB809P Chlamydia trachomatis (LPS) MAB810P Chlamydia trachomatis (LPS) MAB808P Chlamydia trachomatis (MOMP) MAB804P Clostridium difficile toxin A MAB805P Clostridium difficile toxin A MAB811P Clostridium difficile toxin B MAB812P Clostridium difficile toxin B MAB813P Clostridium difficile toxin B MAB764P Cytomegalovirus MAB766P Cytomegalovirus MAB883P Dengue Virus MAB884P Dengue Virus MAB885P Dengue Virus MAB886P Dengue Virus MAB926P Dengue (Pan) MAB770P E. coli serotype O157 MAB771P E. coli serotype O157 MAB772P E. coli serotype O157 MAB836P Giardia lamblia MAB837P Giardia lamblia MAB838P Giardia lamblia MAB839P Giardia lamblia MAB807P Helicobacter pylori PAB134P Hepatitis B Virus MAB7094P Hepatitis C Virus MAB7095P Hepatitis C Virus MAB739P HIV-1 p24 MAB846P HIV-1 p24 MAB721P Influenza A Virus MAB722P Influenza A Virus MAB803P Influenza A Virus PAB7123P Influenza A Virus H1N1 MAB7042P Influenza B Virus MAB7991P Influenza B Virus MAB7992P Influenza B Virus MAB806P Legionella pneumophila MAB134P Mycoplasma pneumoniae MAB135P Mycoplasma pneumoniae MAB853P Mycoplasma pneumoniae MAB854P Mycoplasma pneumoniae MAB855P Mycoplasma pneumoniae MAB856P Mycoplasma pneumoniae MAB223P Norovirus MAB224P Norovirus MAB225P Norovirus MAB226P Norovirus MAB227P Norovirus MAB228P Norovirus MAB923P Plasmodium Aldolase MAB921P Plasmodium falciparum MAB922P Plasmodium falciparum MAB601P Respiratory Syncytial Virus MAB602P Respiratory Syncytial Virus MAB603P Respiratory Syncytial Virus PAB= Polyclonal Antibody INFECTIOUS DISEASE Contact us for a quote at sales@mainebiotechnology.com
INFECTIOUS DISEASE continued HUMAN HORMONES BIOMARKERS MAB= Mouse Monoclonal Antibody PAB= Polyclonal Antibody PAB7133P Respiratory Syncytial Virus MAB7066P Respiratory Syncytial Virus (RSV) MAB7068P Respiratory Syncytial Virus (RSV) MAB7099P Respiratory Syncytial Virus (RSV) MAB7108P Respiratory Syncytial Virus (RSV) MAB7138P Respiratory Syncytial Virus (RSV) MAB239P Rift Valley Fever Virus MAB240P Rift Valley Fever Virus MAB606P Rotavirus MAB830P Rotavirus MAB831P Rotavirus MAB832P Rotavirus MAB833P Rotavirus MAB817P Salmonella common LPS core MAB818P Salmonella common LPS core MAB877P Salmonella LPS core MAB7071P Salmonella species MAB7072P Salmonella species MAB7074P Salmonella typhimurium MAB7076P Streptococcus Group A PAB7137P Streptococcus Group A, affinity purified PAB7139P Streptococcus Group B, affinity purified PAB774P Vaccinia Virus MAB7084P Verotoxin I B subunit (SLT-1b) MAB7086P Verotoxin II A subunit (SLT-2a) MAB872P West Nile Virus MAB873P West Nile Virus MAB874P West Nile Virus MAB875P West Nile Virus MAB876P West Nile Virus MAB105P Chorionic Gonadotropin- Intact (hcg) MAB106P Chorionic Gonadotropin- Beta (hcg-β) MAB107P Chorionic Gonadotropin- Beta (hcg-β) MAB215P Cortisol MAB361P Estradiol 17-Beta MAB111P Follicle-Stimulating Hormone- Alpha (hfsh-α) MAB112P Follicle-Stimulating Hormone- Beta (hfsh-β) MAB116P Luteinizing Hormone- Alpha (hlh-α) MAB115P Luteinizing Hormone- Beta (hlh-β) MAB234P Progesterone MAB235P Progesterone MAB121P Prolactin MAB122P Prolactin MAB128P Thyroid-Stimulating Hormone- Beta (htsh-β) MAB130P Thyroid-Stimulating Hormone- Beta (htsh-β) MAB131P Thyroid-Stimulating Hormone- Beta (htsh-β) MAB132P Thyroid-Stimulating Hormone- Alpha (htsh-α) MAB124P 3,5,3 -Triiodothyronine (T3) MAB125P Thyroxine (T4) MAB101P Alpha-fetoprotein (AFP) MAB149P Angiotensin II, Type 1 receptor PAB105P Bromodeoxyuridine-5 (BrdU) MAB354P C-Reactive Protein (CRP) MAB357P CA 125 MAB358P CA 125 MAB352P Creatine Kinase MB (CK-MB) MAB353P Creatine Kinase MB (CK-MB) MAB236P Human Cystatin C MAB237P Human Cystatin C MAB238P Human Cystatin C MAB359P Eosinophil-MBP Your Partner in Antibody Discovery
MAB= Mouse Monoclonal Antibody PAB= Polyclonal Antibody MAB232P Human Lactoferrin MAB233P Human Lactoferrin MAB208P Human Myeloperoxidase (MPO) MAB209P Human Myeloperoxidase (MPO) MAB222P Human Osteopontin (OPN) MAB193P Human Osteopontin, N-terminal (OPN) MAB194P Human Osteopontin, N-terminal (OPN) MAB195P Human Osteopontin, N-terminal (OPN) MAB196P Human Osteopontin, N-terminal (OPN) MAB197P Human Osteopontin, C-terminal (OPN) MAB362P Human Serum Albumin (HSA) MAB363P Human Serum Albumin (HSA) MAB360P MIF MAB355P Prostate Specific Antigen (PSA) MAB356P Prostate Specific Antigen (PSA) MAB350P Troponin I MAB351P Troponin I MAB167P Canine Heartworm MAB927P Canine IgE MAB928P Canine IgE MAB800 Canine Parvovirus MAB801 Canine Parvovirus MAB202P Equine LH- Beta MAB203P Equine LH- Beta MAB204P Equine LH- Alpha MAB7801P Feline Leukemia Virus gp70 MAB7800P Feline Leukemia Virus p27 MAB7802P Feline Leukemia Virus p27 MAB924P Feline Leukemia Virus p27 MAB925P Feline Leukemia Virus p27 MAB211P Streptococcus equi subsp. equi MAB212P Streptococcus equi subsp. equi MAB241P Glutathione S-Transferase (GST) MAB230P HIS-tag MAB199P Human Ig Kappa Light Chain MAB219P Human Ig Lambda Light Chain MAB217P Human IgA MAB113P Human IgE MAB114P Human IgE MAB142P Human IgG Heavy Chain MAB218P Human IgG Fc MAB146P Human IgG1 MAB220P Human IgG2 MAB221P Human IgG3 MAB154P Human IgG4 Fc MAB216P Human IgM MAB231P Maltose Binding Protein (MBP) MUISO-04P Murine IgG2b MAB206P Polyethylene glycol (PEG) MAB207P Polyethylene glycol (PEG) BIOMARKERS continued VETERINARY CONTROLS/ SECONDARY ABS Contact us for a quote at sales@mainebiotechnology.com
CUSTOM SERVICES Bacterial Recombinant Antigen Production MBS is now offering bacterial recombinant antigen production to our antibody service customers. A unique value Maine Biotechnology Services brings to recombinant protein production is the foresight to anticipate how attributes of the recombinant protein will affect the goals of a hybridoma development program. Customers can expect efficient recombinant antigen development and thorough communication throughout the project. Monoclonal Antibody Development (Hybridoma) Maine Biotechnology Services is a premier provider of antibody services, from design and development to production and characterization. MBS extends the creativity and experience necessary for more complex hybridoma development projects, including small molecules and anti-idiotypic. Tools such as MultiPure technology and Octet Red kinetic analysis are utilized to allow customers the opportunity to refine their clone selection earlier in the process. MBS s development tools and expertise benefit not only service customers but also product customers as these tools are applied in the internal development of new antibody products. Initiation Custom project planning Immunization Rapid high affinity response Fusion Targeted screening to refine clone candidates MultiPure Rapid generation of purified antibody from positive fusion candidates for early evaluation Octet Analysis Establish off rate ranking, matched pair analysis and epitope binning Subcloning Stabilize cell line ReadyPure Discovery scale purification for use evaluating assay performance Polyclonal Antibody Development In cooperation with our NIH (OLAW), USDA, Regulation (EU) 142/2011 approved polyclonal facility, we offer rabbit, sheep, goat and llama polyclonal antibody development, Protein A and G purification and antigen specific affinity purification. Quality polyclonal antibody is produced for pharmaceutical and diagnostic companies, academia and research institutions. Your Partner in Antibody Discovery
cgmp In Vitro Production and Purification MBS offers in vitro cell culture production of monoclonal antibody in roller bottles. Our cgmp facility can accommodate 1L to 100L volumes per lot, generating milligram to gram quantities of antibody. Media formulations containing low IgG fetal bovine serum, serum-free media, or animal component-free media can be used for productions upon request. Productions are designed to limit the introduction of endotoxin. Murine IgG antibodies are purified by protein A gradient elution, resulting in highly pure antibody with little to no aggregation. CUSTOM SERVICES cgmp Ascites Production and Purification MBS offers in vivo antibody production of hybridoma cell lines in our cgmp facility. Antibody productions through mouse ascites provides customers with a cost-effective option for large scale antibody productions. Production parameters are customizable and MBS ascites production technicians follow carefully regulated operating procedures. Murine IgG antibodies are purified by protein A gradient elution, resulting in highly pure antibody with little to no aggregation. Mycoplasma Decontamination Decontaminate mycoplasma-positive hybridoma cell lines in vivo in 4-5 weeks. Cells are expanded and injected into 3 mice for clearance of the contamination. The cells are retrieved from the peritoneal cavity of the mouse and retested for mycoplasma. Once confirmed negative, the cells are subcloned to monoclonality and screened against the specific antigen. Monoclonal Antibody Characterization Determination of an antibody s unique characteristics is essential in the development of a successful assay. Antibody characterization via: ELISA: Confirm antibody specificity via immunoassay format Western Blot: Confirm antibody specificity via immunoblot format Size Exclusion Chromatography (SEC): Determine purity Isoeletric Focusing (IEF): Determine the isoelectric point (pl) and reveal the isoform profile Assay Development MBS is extending the benefit of our assay development experience to our hybridoma customers. At the end of your antibody development, MBS s assay development service provides customers with refined, R&D use assays. Optimization of reagents for assay applications has long been an area of core competency for MBS, used heavily in the development of internal products and services. Contact us for a quote at sales@mainebiotechnology.com
1037R Forest Avenue, Portland, Maine 04103 T. 207.797.5454 F. 207.797.5595 www.mainebiotechnology.com