Similar documents
( TUTORIAL. (July 2006)

Hands on Simulation of Mutation

Mutation. Mutation provides raw material to evolution. Different kinds of mutations have different effects

Gene Finding CMSC 423

Molecular Facts and Figures

UNIVERSITETET I OSLO Det matematisk-naturvitenskapelige fakultet

GENEWIZ, Inc. DNA Sequencing Service Details for USC Norris Comprehensive Cancer Center DNA Core

(A) Microarray analysis was performed on ATM and MDM isolated from 4 obese donors.

The p53 MUTATION HANDBOOK

Protein Synthesis Simulation

Table S1. Related to Figure 4

Biological One-way Functions

DNA Bracelets

Hiding Data in DNA. 1 Introduction

10 µg lyophilized plasmid DNA (store lyophilized plasmid at 20 C)

Mutations and Genetic Variability. 1. What is occurring in the diagram below?

DNA Sample preparation and Submission Guidelines

Introduction to Perl Programming Input/Output, Regular Expressions, String Manipulation. Beginning Perl, Chap 4 6. Example 1

Coding sequence the sequence of nucleotide bases on the DNA that are transcribed into RNA which are in turn translated into protein

Part ONE. a. Assuming each of the four bases occurs with equal probability, how many bits of information does a nucleotide contain?

Supplementary Online Material for Morris et al. sirna-induced transcriptional gene

Chapter 9. Applications of probability. 9.1 The genetic code

Insulin mrna to Protein Kit

Gene Synthesis 191. Mutagenesis 194. Gene Cloning 196. AccuGeneBlock Service 198. Gene Synthesis FAQs 201. User Protocol 204

UNIT (12) MOLECULES OF LIFE: NUCLEIC ACIDS

Inverse PCR & Cycle Sequencing of P Element Insertions for STS Generation

Supplementary Information. Binding region and interaction properties of sulfoquinovosylacylglycerol (SQAG) with human

Next Generation Sequencing

SERVICES CATALOGUE WITH SUBMISSION GUIDELINES

ANALYSIS OF A CIRCULAR CODE MODEL

Inverse PCR and Sequencing of P-element, piggybac and Minos Insertion Sites in the Drosophila Gene Disruption Project

SEAC 2012 Medical Director Potpourri BANNER. WILLIAM PENN. YOUR COMPANY FOR LIFE

Molecular analyses of EGFR: mutation and amplification detection

Drosophila NK-homeobox genes

Characterization of cdna clones of the family of trypsin/a-amylase inhibitors (CM-proteins) in barley {Hordeum vulgare L.)

Supplemental Data. Short Article. PPARγ Activation Primes Human Monocytes. into Alternative M2 Macrophages. with Anti-inflammatory Properties

pcas-guide System Validation in Genome Editing

a. Ribosomal RNA rrna a type ofrna that combines with proteins to form Ribosomes on which polypeptide chains of proteins are assembled

Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians

Introduction to Bioinformatics (Master ChemoInformatique)

Marine Biology DEC 2004; 146(1) : Copyright 2004 Springer

BD BaculoGold Baculovirus Expression System Innovative Solutions for Proteomics

Cloning, sequencing, and expression of H.a. YNRI and H.a. YNII, encoding nitrate and nitrite reductases in the yeast Hansenula anomala

CHALLENGES IN THE HUMAN GENOME PROJECT

Insulin Receptor Gene Mutations in Iranian Patients with Type II Diabetes Mellitus

All commonly-used expression vectors used in the Jia Lab contain the following multiple cloning site: BamHI EcoRI SmaI SalI XhoI_ NotI

ANALYSIS OF GROWTH HORMONE IN TENCH (TINCA TINCA) ANALÝZA RŮSTOVÉHO HORMONU LÍNA OBECNÉHO (TINCA TINCA)

pcmv6-neo Vector Application Guide Contents

The making of The Genoma Music

Molecular chaperones involved in preprotein. targeting to plant organelles

Ribosomal Protein Synthesis

Title : Parallel DNA Synthesis : Two PCR product from one DNA template

Module 6: Digital DNA

and revertant strains. The present paper demonstrates that the yeast gene for subunit II can also be translated to yield a polypeptide

BIOLÓGIA ANGOL NYELVEN

The University of the State of New York REGENTS HIGH SCHOOL EXAMINATION LIVING ENVIRONMENT. Tuesday, January 25, :15 a.m. to 12:15 p.m.

The nucleotide sequence of the gene for human protein C

Provincial Exam Questions. 9. Give one role of each of the following nucleic acids in the production of an enzyme.


Transmembrane Signaling in Chimeras of the E. coli Chemotaxis Receptors and Bacterial Class III Adenylyl Cyclases

Gene and Chromosome Mutation Worksheet (reference pgs in Modern Biology textbook)

The DNA-"Wave Biocomputer"

Mutation of the SPSl-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation

Biopython Tutorial and Cookbook

Five-minute cloning of Taq polymerase-amplified PCR products

Heraeus Sepatech, Kendro Laboratory Products GmbH, Berlin. Becton Dickinson,Heidelberg. Biozym, Hessisch Oldendorf. Eppendorf, Hamburg

N-terminal Regulatory Domains of Phosphodiesterases 1, 4, 5 and 10 examined with an Adenylyl Cyclase as a Reporter

NimbleGen SeqCap EZ Library SR User s Guide Version 3.0

How To Clone Into Pcdna 3.1/V5-His

Nucleotide sequence and the encoded amino acids of human serum

Molecular detection of Babesia rossi and Hepatozoon sp. in African wild dogs (Lycaon pictus) in South Africa

Metabolic Engineering of Escherichia coli for Enhanced Production of Succinic Acid, Based on Genome Comparison and In Silico Gene Knockout Simulation

DNA Sequencing of the eta Gene Coding for Staphylococcal Exfoliative Toxin Serotype A

DISSERTATIONES MEDICINAE UNIVERSITATIS TARTUENSIS 108

were demonstrated to be, respectively, the catalytic and regulatory subunits of protein phosphatase 2A (PP2A) (29).

Problem Set 3 KEY

Six Homeoproteins and a Iinc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype

Archimer

Event-specific Method for the Quantification of Maize MIR162 Using Real-time PCR. Protocol

Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk

pentr Directional TOPO Cloning Kits

Production and Characterization of a Murine/Human Chimeric Anti-Idiotype Antibody That Mimics Ganglioside1

C YTOPLASMIC organelles proliferate by the growth and

cdna sequence and expression pattern of the putative

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer s disease is this type 3 diabetes?

The University of the State of New York REGENTS HIGH SCHOOL EXAMINATION LIVING ENVIRONMENT. Monday, January 26, :15 a.m. to 12:15 p.m.

Interleukin-4 Receptor Signal Transduction: Involvement of P62

inhibition of mitosis

BioTOP-Report. Biotech and Pharma in Berlin-Brandenburg

The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis

The University of the State of New York REGENTS HIGH SCHOOL EXAMINATION LIVING ENVIRONMENT. Wednesday, January 23, :15 a.m. to 12:15 p.m.

ISTEP+: Biology I End-of-Course Assessment Released Items and Scoring Notes

Mutation, Repair, and Recombination

TITRATION OF raav (VG) USING QUANTITATIVE REAL TIME PCR

pbad/his A, B, and C pbad/myc-his A, B, and C

BioTOP-Report. Biotech and Pharma in Berlin-Brandenburg

9. Materials. 9.1 Chemicals Acetic Acid (glacial) Materials. 8-Aminoguanosine Ammonium Hydroxide Ammonium Persulfate.

4 th DVFA Life Science Conference. Going East / Going West. Life Science Asia/Europe getting insight in mutual growth opportunities

Chapter 5. Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development

Transcription:

1 «. XXI (... ),, 2006,.216-250 ( )... petoukhov@hotmail.com, http://www.petoukhov.narod.ru,, ( ),..,,,.,,,.. Genbank : «,?,,.,,,.» [, 1999,. 14]..,..,,,.., -, (, ),.,,,,.,

2,.,.,..,.,..,,..,,.,,,.,,,..,,, (. 1): ( ), ( ), (G), (U) ( ( )). ( ). -G A-U,.. 1. :

3 - ( ), - G ( )..,, N, O.., (, )., ( ),. 20.,, 40 000,.., ( ). 4 3 = 64., 20., 64 20,,, -. n, ( ) 3n,, 3n-.. 64.... (. 2).,, P (n), ( ) (, n, ).,. (n) n,, :,,. (n) n-,,, U, G. n-,, (n) (n-1) ( ). (n) n, ( ). (n),

4 n-,.,. 11 10 01 00 1 0 11 CC CA AC AA 1 10 CU C AU A = (2) = G 0 U G, = 01 UC UA G C 00 UU U G 111 110 101 100 011 010 001 000 111 CCC CCA CAC CAA ACC ACA AAC AAA 110 CCU CCG CAU CAG ACU ACG AAU AAG 101 CUC CUA CGC CGA AUC AUA AGC AGA P (3) = 100 CUU CUG CGU CGG AUU AUG AGU AGG 011 UCC UCA UAC UAA GCC GCA GAC GAA 010 UCU UCG UAU UAG GCU GCG GAU GAG 001 UUC UUA UGC UGA GUC GUA GGC GGA 000 UUU UUG UGU UGG GUU GUG GGU GGG. 2. (n) n = 1, 2, 3 /, 2001/.,, G, U.,, [, 2001; Petoukhov, 1999, 2001a]., U, G. ( ), U 1, G 0. ( ) -, ( ): 1,,, - 0 ( ).. 2.,., AU 101 (, ), 110 (, ).. G U G G A G G

5 (3) 64. [Wittmann, 1961],.,. (n)... ( C=G=3, A=U=2),. P (n).,, G P (3) 3 3 2=18. (n) (.17.1): (1) = 32 23 ; (2) = 9 6 6 4 6 9 4 6 6 4 9 6 4 6 6 9 ; (3) = 27 18 18 12 18 12 12 8 18 27 12 18 12 18 8 12 18 12 27 18 12 8 18 27 12 18 18 27 8 12 12 18 18 12 12 8 27 18 18 12 12 18 8 12 18 12 27 18 12 8 18 12 18 12 27 18 8 12 12 18 12 18 18 27.17.1. (n), (C=G=3, A=U=2). (n). (n) 5 n, 10 n., (3) 125, 1000., 3/2,,.,.17.1 27, 18, 12, 8,. (n) = (1+50.5)/2 = 1,618, (n) MULT = ( (n) MULT ) 1/2, (.17.2)., (. [, 2004, 2006; Petoukhov, 2001, 2005]). (P ) 1/2 = = = -1-1 ; (P (2) ) 1/2 = = (2) = 2 0 0-2 0 2-2 0 0-2 2 0-2 0 0 2 3 1 1-1 1-1 -1-3 1 3-1 1-1 1-3 -1 (3) = 1-1 3 1-1 -3 1-1 =( (3) ) 1/2 = -1 1 1 3-3 -1-1 1 1-1 -1-3 3 1 1-1 -1 1-3 -1 1 3-1 1-1 -3 1-1 1-1 3 1-3 -1-1 1-1 1 1 3.17.2. (P (n) ) 1/2 = (n) ; -

6, : -,,,. ( ).,.,,.,,.,,, ( - ).,,,.. [, 2004; Petoukhov, 2005]... (n)... ( C=G=3, A=U=2),. P (n).,, G P (3) 3 3 2=18. (n)., (3) (.3): (3) 27 18 18 12 18 12 12 8 125 18 27 12 18 12 18 8 12 125 18 12 27 18 12 8 18 12 125 12 18 18 27 8 12 12 18 125 = 18 12 12 8 27 18 18 12 125 12 18 8 12 18 27 12 18 125 12 8 18 12 18 12 27 18 125 8 12 12 18 12 18 18 27 125 125 125 125 125 125 125 125 125 1000. 3. (3), (C=G=3, A=U=2).... (n),.., (n) 5 n, 10 n., (3) 125, 1000. (3) 5 12.

7., (n),,, (,.).. : -,,,.,. = (1+5 0.5 )/2 = 1, 618, (n) (n) (n) : = ( (n) ) 2. (3) (. 4). 64, 1 3, ( - ): +1-1 ; +3-3.,,. (n), (n),. (n) (.. 2) : = G =, A = U = -1., G P (3) -1 =. (3) 3 1 1-1 1-1 -1-3 1 3-1 1-1 1-3 -1 1-1 3 1-1 -3 1-1 = ( (3) ) 1/2 = -1 1 1 3-3 -1-1 1 1-1 -1-3 3 1 1-1 -1 1-3 -1 1 3-1 1-1 -3 1-1 1-1 3 1-3 -1-1 1-1 1 1 3. 4. (3) = (P (3) ) 1/2,. (n) ( ) 1/2.,. : P = 3 2 2 3 ; (P ) 1/2 = = = -1-1 ; (P (2) ) 1/2 = = (2) = 2 0 0-2 0 2-2 0 0-2 2 0-2 0 0 2. 5. (P (n) ) 1/2 = (n),. - : ( -1 ), P,

8 (C=G=3, A=U=2). :,,.,, -1 ( -1 ).. -.,.,,,, [Petoukhov, 2001a].. -, [Petoukhov, 2001a, 2003;, 2004]. ( (3) ) 1/2 = (3). : +1-1 ; +3-3,. +3-3,., -1,, «69» (. 6)., +1, «69».. 6. -1 (, ) +1 ( ),,,, ( 64 ). (3) -.,,., ( (3) ) 2 = (3) 8, 12, 18 27.,,,. -,.

9,, (. 7). X(a, b, c, d) * Y(k, m, p, q) = Z(r, g, v, z). 7. - ( ),,,,,.., -,.,.,,,,.,, (n)? -1 0 2-2 0. 3 1 1-1 1-1 -1-3 1 3-1 1-1 1-3 -1 1-1 3 1-1 -3 1-1 2 0 0-2 -1 1 1 3-3 -1-1 1-1 1-1 -1-3 3 1 1-1 0-2 2 0-2 0 0 2-1 1-3 -1 1 3-1 1-1 -3 1-1 1-1 3 1-3 -1-1 1-1 1 1 3. 8. (n) (n) n = 2, 3, 4,,,,..

10,,,, [Petoukhov, 2003].., ( )., (3) «96». : «69», «96».,,, : [sh x ch x ; ch x sh x] ((,,, Matlab)., [, 2004 ].,, -, [, 1999]. (2 2). i = (-1) 1/2, : i = Arch(1/(2* )) / arccos (1/(2* )) ; i = Arch[cos(0,4* )] / (0,4* ), (1) Arch arc os., «-» [, 2003,. 255],.. (. 2),,.,,.,,, (. 9). P i ( i ) =G=3, A=U=2 (P i ) (n), (P ) (n).,. 9. -,,,, ( i ). (P i ) (n). 0 -i C -ia 3-2i - ( -1 )i i 0 ; P i = iu G ; P i = 2i 3 ; (P i ) 1/2 = i = ( -1 )i 3 - i - i - -1 - i - -1 - -1 ( -3 )i

11 i 3-1 - i -1 - i -( -3 )i - -1 i -1 3 - i -1 -( -3 )i - i - -1 ( i ) ) (3) = - -1 i i 3 ( -3 )i -1-1 - i i -1-1 -( -3 )i 3 - i - i - -1 - -1 i ( -3 )i -1 i 3-1 - i - -1 ( -3 )i i -1 i -1 3 - i -( -3 )i - -1 - -1 i - -1 i i 3. 9. P i. =G=3, A=U=2 (P i ), ( i ). i.. ( ) (. ).,. [Cook, 1914]. -,, : 1/3*[ -1 ; - -1 ] = [cos sin ; -sin cos ].. 72 0 36 0 ( ) : = ( 10/3 ) * asin( /2) ; = 10 * arcsin[1/(2* )] (2),, i,, ( ).,,.,.., ( ), (. [, 1981]).,,,... 20 (3), 64?. (3) -.,,,., 64

12 20,,.,, (3) [, 2001].. 10 -,. (3) (2 2),. NN-. 16 NN- 8.,. 10, NN-,.. NN-,,, ( - ). NN- P (3)., - - :,,.,,. 1-2, 3-4, 5-6, 7-8. 111 CCC Pro 63 110 CCU Pro 55 101 CUC Leu 47 100 CUU Leu 39 111 110 101 100 011 010 001 000 CCA Pro 62 CCG Pro 54 CUA Leu 46 CUG Leu 38 CAC His 61 CAU His 53 CGC Arg 45 CGU Arg 37 CAA Gln 60 CAG Gln 52 CGA Arg 44 CGG Arg 36 ACC Thr 59 ACU Thr 51 AUC Ile 43 AUU Ile 35 ACA Thr 58 ACG Thr 50 AUA Met 42 AUG Met 34 AAC Asn 57 AAU Asn 49 AGC Ser 41 AGU Ser 33 AAA Lys 56 AAG Lys 48 AGA Stop 40 AGG Stop 32 011 UCC Ser 31 UCA Ser 30 UAC Tyr 29 UAA Stop 28 GCC Ala 27 GCA Ala 26 GAC Asp 25 GAA Glu 24 010 UCU Ser 23 UCG Ser 22 UAU Tyr 21 UAG Stop 20 GCU Ala 19 GCG Ala 18 GAU Asp 17 GAG Glu 16 001 UUC Phe 15 UUA Leu 14 UGC Cys 13 UGA Trp 12 GUC Val 11 GUA Val 10 GGC Gly 9 GGA Gly 8 000 UUU UUG UGU UGG GUU GUG GGU GGG

13 Phe 7 Leu 6 Cys 5 Trp 4 Val 3 Val 2 Gly 1 Gly 0. 10. 20 (3) /, 2001,. 99 106/. 20 Pro, His, Gln. - stop. (2 2), NN-,,, NN-. 0 63. 20 8 (3), 12. 20 (3),.. 64 20. 17, «National Center for Biotechnology Information ( )»: http://www.ncbi.nlm.nih.gov/taxonomy/utils/wprintgc.cgi. 20.. 20, 1 8., Thr,.. 4, - 8.. 20 1 8 1 3 4 8 1 2 3 4 5 6 7 8 1) The Vertebrate Mitochondrial Code 12 6 2 12 8 2) The Standard Code 2 9 1 5 3 12 8 3) The Mold, Protozoan, and Coelenterate Mitochondrial Code and the Mycoplasma /Spiroplasma Code 1 10 1 5 3 12 8 4) The Invertebrate Mitochondrial Code 12 6 1 1 12 8 5) The Echinoderm Mitochondrial Code 2 8 2 6 1 1 12 8 6) The Euplotid Nuclear Code 2 8 2 5 3 12 8 7) The Bacterial and Plant Plastid Code 2 9 1 5 3 12 8 8) The Ascidian Mitochondrial Code 12 5 3 12 8 9) The Flatworm Mitochondrial Code 2 7 3 6 1 1 12 8 10) Blepharisma Nuclear Code 2 8 2 5 3 12 8

14 11) Chlorophycean Mitochondrial Code 2 9 1 5 2 1 12 8 12) Trematode Mitochondrial Code 1 10 1 6 1 1 12 8 13) Scenedesmus obliquus mitochondrial Code 2 9 1 5 1 1 1 12 8 14) Thraustochytrium Mitochondrial Code 2 9 1 5 1 2 12 8 15) The Alternative Yeast Nuclear Code 2 9 1 5 1 1 1 12 8 16) The Yeast Mitochondrial Code 13 5 1 1 13 7 17) The Ciliate, Dasycladacean and Hexamita Nuclear Code 2 8 1 6 3 11 9. 11. 20 - ( /, 2001/). ( 1 3) ( 4 8).,.,,.,.,,. 17,.,, 20 - ( 1 3) ( 4 8).. 11 1 [, 2004; Petoukhov, 2001] : - 20 : 12 ( 1 3), 8 ( 4 8). :, 11:9 13:7. 12:8 (, 20),.,., 20 12 8 NN- P (3). NN- (. 10) Ala, Arg, Gly, Leu, Pro, Ser, Thr, Val, Asn, Asp, Cys, Gln, Glu, His, Ile, Lys, Met, Phe, Trp, Tyr NN-. 8 12., 2: - -, ( ).,

15,,,. UAG, Leu Gln,. 2 -,,,. 10 - ( ), ( - )., 17,. : -,.,,,., 20 8 12 ( - ).. 1: 8 12 24. 2: 1, 2, 3, 4, 6, 8-24 (, 5 7; 17 0,88 %). :, 12 ( 24) [Petoukhov, 2001b].,, 24. 24,,, 24., «-»,,,. 24,.,,. 24 [Petoukhov, 2001b;, 2004]: ( ) 24-.

16.,,. (?) (),. [Petoukhov, 2001b;, 2004]. -,..? (),,. -,, 1:3 2:2 4:0 1:2:1. «-» [, 2004, ].. ( ),,,.. «?»,. ( ) - 1:3,,. :. ( ),.. - 4:0. - - : «( ).,, 3+1,,.,, -,» ( [, 1998,. 202]). : «-,.,. - ( ),» [,. 201].

17 -, 3:1.,, G, U ( ), ( ). - 3:1., N- G- 17,. -. 10, N-,, - NN- 3:1. NN- -, - 1:3 2:2 4:0 1:2:1. 17 - NN- 1:1:1:1., NN-, -..,,, - (1:3 2:2 4:0 1:2:1),,. - ( ) ([, 2004, ])..,,. -,,. -,. (. [, 2004, ]). -. - ( ),?, - 1:3?., 51 ( - ATG - 52 = 4 13): - - (21, ): 1GGC 2ATC 3GTT 4GAA 5CAG 6TGT 7TGC 8ACT 9TCT 10ATC 11TGC 12TCT 13CTT 14TAC 15CAG 16CTT 17GAG 18AAC 19TAC 20TGT 21AAC ;

18 - - (30, ): 1TTC 2GTC 3AAT 4CAG 5CAC 6CTT 7TGT 8GGT 9TCT 10CAC 11CTC 12GTT 13GAA 14GCT 15TTG 16TAC 17CTT 18GTT 19TGC 20GGT 21GAA 22CGT 23GGT 24TTC 25T TC 26TAC 27ACT 28CCT 29AAG 30ACT. 51 13 G- 38 A-, C- U- ( - ATG 39 ), 1:3. - EG13077 Escherichia: ATG-GTT-CAG-AAG-CCC-CTC-ATT-AAG-CAG-GGA-TAT-TCA-CTG-GCA-GAG-GAA-ATA-GCC-AAC- AGC-GTC-AGT-CAC-GGC-ATT-GGG-TTG-GTG-TTT-GGT-ATC-GTT-GGG-CTG-GTG-TTG-CTA-CTG- GTT-CAG-GCG-GTG-GAT-CTT-AAT-GCC-AGC-GCC-ACA-GCG-ATA-ACC-AGC-TAC-AGC-CTC-TAT- GGC-GGC-AGT-ATG-ATC-CTG-CTG-TTC-CTC-GCT-TCG-ACG-CTC-TAT-CAC-GCC-ATT-CCT-CAT-CAA- CGG-GCA-AAA-ATG-TGG-CTG-AAG-AAA-TTT-GAC-CAT-TGC-GCT-ATT-TAC-CTG-TTG-ATT-GCC- GGA-ACC-TAC-ACG-CCG-TTT-TTG-CTG-GTG-GGG-CTG-GAT-TCT-CCG-TTA-GCG-CGC-GGG-TTG- ATG-ATT-GTT-ATC-TGG-AGC-CTG-GCA-TTG-CTG-GGT-ATT-CTG-TTT-AAA-CTG-ACC-ATC-GCG-CAC- CGA-TTC-AAA-ATT-TTA-TCT-CTG-GTG-ACC-TAT-CTG-GCG-ATG-GGC-TGG-CTG-TCG-CTG-GTG-GTA- ATT-TAT-GAA-ATG-GCA-GTT-AAG-CTC-GCG-GCG-GGC-AGC-GTT-ACC-TTA-CTG-GCG-GTA-GGC- GGC-GTG-GTT-TAT-CG-CTC-GGG-GTG-ATT-TTC-TAC-GTC-TGC-AAA-CGC-ATT-CCA-TAC-AAC-CAT- GCC-ATC-TGG-CAC-GGC-TTC-GTG-CTC-GGC-GGT-AGT-GTG-TGC-CAC-TTT-CTG-GCG-ATC-TAT- TTG-TAT-ATT-GGG-CAG-GCG-TAA 220 55 - ( ) 165 (50 -, 69 -, 46 G- ) 55:165=1:3.,, - N- 1:3. -.,. -,,. 20?. : 20, 8 12 [Petoukhov, 2001b; 2004a].,, : 8 12 20?,,. - - : 8 = 4 2 12 = 4 3. - 8 2, 12 3. 8, 12. -.,,.?., 20 8 12,

19 -,., «-» 20 8 12., 8 12 -, «-», «-» ( ), «-» ( ) (. /, 2004; Petoukhov, 2004c/)., 20, -., 8 12-2 3 (8=4 2 12=4 3). 12. 20 8 12.,,,,,. ( ).. 10, N-., N-. (. [, 2004, ]). 8 = 4 2 - Pro, Arg (C- ) Lys, Met (A- ) Phe, Tyr (U- ) Ala, Gly (G- ) 20 12 = 4 3 - Gln, His, Leu (C- ) Asn, Ile, Thr (A- ) Cys, Trp, Ser (U- ) Asp, Glu,Val (G- ). 12. 20 ( ) 8 12. -, N-...,,.,.

20. (., [,, 1989,. 61]).,.,,, (P i ) (n) ( i ) (n) (. 9),..,.,,.., -,, -.,..,.,.., [, 2003,. 753]. (3) (. 2), 4 64, -., (, G, A, U),., ( ) - ;, [, 2001]. : C=U=1, A=G=0 ( ); = =1, U=G=0 ( ); C=G=1, A=U=0 ( ). n- (n)., CGA 100; 101; 110. (n), n, n. (n) - (n) 1, (n) 2, (n) 3,.. 13 - (2) - (2) 1, (2) 2, (2) 3. CC CA AC AA 11 10 01 00 11 11 11 11 11 10 01 00

21 CU CG AU AG 11 10 01 00 10 10 10 10 10 11 00 01 UC UA GC GA ; 11 10 01 00 ; 01 01 01 01 ; 01 00 11 10 UU UG GU GG 11 10 01 00 00 00 00 00 00 01 10 11. 13. (2) - (2) 1, (2) 2, (2) 3. - (n),,,. - (n) 1, (n) 2, (n) 3.,. - (N) ( N N- ). (3n) 3n-,,...,, (n), ( ),,.,,,. (3n) (3),.,,,.... 1969, : «, 3000,.,., » [G. Stent, 1969,.64].,,,.,,,., « -,,» [, 1998,.92].

22,., : «, » [F.Jacob, 1974].,..,, ( 1) ( 0). (. 14, ). ( 11 ) ( 10 ) ( 01 ) ( 00 ) 111 110 101 100 011 010 001 000 111 111111 111110 111101 111100 111011 111010 111001 111000 110 110111 110110 110101 110100 110011 110010 110001 110000 101 101111 101110 101101 101100 101011 101010 101001 101000 100 100111 100110 100101 100100 100011 100010 100001 100000 011 011111 011110 011101 011100 011011 011010 011001 011000 010 010111 010110 010101 010100 010011 010010 010001 010000 001 001111 001110 001101 001100 001011 001010 001001 001000 000 000111 000110 000101 000100 000011 000010 000001 000000. 14. ( ) 64 - ( ). 64, - [, 1997;, 1993;, 1994;, 2001]. 0 1. 14.,, (,,,..) [, 1997,. 101].,., (3) [, 2001]., (3). 2 (.. ),,, -,. 14,.,,,,.

23,.. 2 3,, [, 1994,. 15]. [, 2001,. 61] (3) (A=G=9, C=U=T=6).,, 144, 168, 168, 192, 168, 192, 192, 216.,, [, 2003,. 269-292]. 8 12,, «- 8 12. 8 12, 8 12.. 8 12 - » [, 1994,. 39-40]. 6, 7, 8 9 [, 1997,. 22, 522]., : 6 ( 6 ), N 7, 8, NH 2 9 [, 2001].,, [, 2001]. -, [, 2002]. 1:., (n) (.. 2) (C=G=3, A=U=2),, (n). 4, 5. (3)., =1, 2, 3. (. 15) (3) : 1),, :, CGA 1 C, 2 G, 3 A; 2) : =G=3, A=U=2. 3 3 3 3 2 2 2 2 3 3 2 2 3 3 2 2 3 2 3 2 3 2 3 2 3 3 3 3 2 2 2 2 3 3 2 2 3 3 2 2 2 3 2 3 2 3 2 3 3 3 3 3 2 2 2 2 2 2 3 3 2 2 3 3 3 2 3 2 3 2 3 2 3 3 3 3 2 2 2 2 ; 2 2 3 3 2 2 3 3 ; 2 3 2 3 2 3 2 3 2 2 2 2 3 3 3 3 3 3 2 2 3 3 2 2 3 2 3 2 3 2 3 2 2 2 2 2 3 3 3 3 3 3 2 2 3 3 2 2 2 3 2 3 2 3 2 3

2 2 2 2 3 3 3 3 2 2 3 3 2 2 3 3 3 2 3 2 3 2 3 2 2 2 2 2 3 3 3 3 2 2 3 3 2 2 3 3 2 3 2 3 2 3 2 3 B B B 1 2 3 24 ; ; 1 2 3. 15. : B 1, B 2, B 3, (3), C=G=3, A= U =2. :, = ( 1 + 5 1/2 )/2 = 1, 618 = -1. 2 (B ). 2 3 -., = 1, 2, 3, : -1 (.. 15, = -1 ). 4 = 2.,, [, 2003]..,,, 1 2 = 2 3 = 1 3, 10., -1 12 8. 2:. (n) (n). (n) 2 n -, ( ) (n)., 1 (, -1 ) 2 ( -1, ),, = [3 2; 2 3]..,,..,.,,,.,,,

25.,,,.,. 2 3 -,.,, 6 9., ( -, http://us.geocities.com/symmetrion/) ( -,, http://polaris. nova.edu/mst/issb)...,..,.,..,.,.,.. : 1....., 2003. 2....,., 1981. 3..,,, 1998, 210. 4.....,, 2003. 5....-.,, 2002, 534. 6.....,, 1993, 383. 7....,, 1998. 8.....,, 1994, 432. 9...,.... -,. 223, 2, 471-474, 1975. 10...,.... 4-..,, 1989 11. (... ),.,, 1999. 12......, 1999, 288. 13.... /...., 2001, 258. 14.... - «,,»,, 2003,. 161-169..,. 15,, 2003. 15.... :..,.., 3-,, 2004a,. 482-513. 16.... - 02.02.2004b, 30., 182-2004 (, 4, 2004.).

26 17.... - 07.06.2004c, 30., 964-2004 (, 8, 2004 ). 18....., ITI, 2003, 261 c. 19...,,, 2003,. 68-75. 20...., 1997, 605. 21. Cook T.A. The curves of life. - L.: Constable and Co, 1914, 490 p. 22. He M., Petoukhov S., Ricci P. Genetic Code, Hamming Distance and Stochastic Matrices. Bulletin for Mathematical biology, 2004 ( ) 23. Jacob F. Le modele linguistique en biologie. - Critique, Mars 1974, tome XXX, 322, p.197-205 24. Petoukhov S.V. Genetic Code and the Ancient Chinese Book of Changes. - Symmetry: Culture & Science, vol. 10, 3-4, 1999,.211-226. 25. Petoukhov S.V. Genetic Codes I: Binary sub-alphabets, bi-symmetric matrices and golden section.- Symmetry in Genetic Information, ed. Petoukhov S.V., special issue of the journal Symmetry: Culture and Science, Budapest, 2001a: Internat. Symmetry Foundation,. 255-274 26. Petoukhov S.V. Genetic Codes II: Numeric Rules of Degeneracy and a Chronocyclic Theory. - Symmetry in Genetic Information, ed. Petoukhov S.V., ISBN 963216 242 0, special double issue of the journal Symmetry: Culture and Science, Budapest, 2001b: International Symmetry Foundation,. 275-306. 27. Petoukhov S.V. The Biperiodic Table and Attributive Conception of Genetic Code. A Problem of Unification Bases of Biological Languages. In: Proceedings of The 2003 International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, session Bioinformatics 2003, Las Vegas, June 23-26, 2003. 28. Petoukhov S.V. Attributive conception of genetic code, its bi-periodic tables and a problem of unification bases of biological languages.- Symmetry: Culture and Science, 2003, # 1-4, p.40-59 29. Stent G.S. The Coming of the Golden Age. - N-Y, The Natural History Press, 1969. 30. Wittmann H.G. Ansatze zur Entschlusselung des genetishen Codes. Die Naturwissenschaften, 1961, B.48, 24, S. 55