Guide to NeuroQuant REPORT DESCRIPTIONS OVERVIEW

Guide to NeuroQuant REPORT DESCRIPTIONS OVERVIEW

Automated Brain Image Analysis Fast, Proven and Accurate: The NeuroQuant Difference 5 volumetric reports helpful in the assessment of brain volume development/atrophy Unique Dynamic Atlas technology for increased segmentation accuracy across a broad age range from 3 to 100 years Secure cloud or locally installed systems Standardized, proven 3D T1 non-contrast sagittal MRI Compatible with GE, Philips, Siemens (1.5T and 3.0T) Multiplatform support OS X, Windows and Linux FDA Cleared (2006) and CE Marked (2014) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 2

NeuroQuant Report Overview NeuroQuant Reports provide Brain images aligned to atlas Extensive set of segmented, colorcoded subcortical brain structures Simplified identification of brain volumes and changes Longitudinal tracking ongoing evaluations Slices consistent across time points Easy recognition between reports sorted by color September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 3

NeuroQuant Report Information Color Report Age Related Atrophy Hippocampal Volume Asymmetry Multi Structure Atrophy Triage Brain Atrophy Brain Development Clinical condition Age associated neurodegenerative conditions Alzheimer s disease Frontotemporal dementia Dementia with Lewy bodies Hippocampal sclerosis Temporal lobe epilepsy Unilateral degenerative conditions Multiple Sclerosis Age associated neurodegenerative conditions Age associated neurodegenerative conditions Wide assessment of atrophy in brain regions and structures Brain development in children ages 3 and up September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 4

Age Related Atrophy Report Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing hippocampal occupancy score, as well as hippocampus, lateral ventricles and inferior lateral ventricles in raw volume, intracranial volume (ICV) percentage and normative percentile Age-matched reference charts for hippocampus, mesial temporal lobe and inferior lateral ventricles September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 5

Age Related Atrophy Report Mesial temporal Volume or Hippocampal Occupancy A ratio of hippocampal volume to the sum of the hippocampal and ILV volumes An estimate of mesial temporal lobe atrophy that accounts for tissue loss and inferior lateral ventricle expansion Detailed information table for hippocampi, lateral ventricles and inferior lateral ventricles Brain structure volume in cc or cm 3 Percent of Intracranial Volume (% of ICV) Structures as they relate to the size of the head Normative Percentile As the structure relates to a normative population of healthy individuals with the same imaging parameters Normative Reference Charts Displays normative percentile in visual form X-axis is Age (years) and Y-axis is Volume (% of ICV) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 6

Brain Development Report Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing intracranial volume, forebrain parenchyma and lateral ventricles in raw volume, intracranial volume (ICV) percentage and normative percentile Age and gender matched reference charts for left and right forebrain parenchyma and lateral ventricles September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 7

Brain Development Report Detailed information table for intracranial volume, forebrain parenchyma and lateral ventricles Brain structure volume in cc or cm 3 Percent of Intracranial Volume (% of ICV) Structures as they relate to the size of the head Normative Percentile As the structure relates to a normative population of healthy individuals with the same imaging parameters Normative Reference Charts Displays normative percentile in visual form X-axis is Age (years) and Y-axis is Volume (% of ICV) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 8

Hippocampal Volume Asymmetry Report Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing left and right hippocampus in raw volume, intracranial volume (ICV) percentage and normative percentile, and Left-Right Asymmetry Index Age-matched reference charts for left and right hippocampi, and asymmetry between them September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 9

Hippocampal Volume Asymmetry Report Detailed information table for the left and right hippocampi and asymmetry between them Hippocampus volume in cc or cm 3 Percent of Intracranial Volume (% of ICV) Right and left hippocampus as they relate to the size of the head Normative Percentile As the right and left hippocampus relate to a normative population of healthy individuals with the same imaging parameters Normative Reference Charts Displays normative percentile in visual form X-axis is Age (years) and Y-axis is Volume (% of ICV) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 10

Multi Structure Atrophy Report (page 1) Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing whole brain, lateral ventricles and thalami in raw volume, intracranial volume (ICV) percentage and normative percentile Age-matched reference charts for whole brain, left and right ventricles and thalami September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 11

Multi Structure Atrophy Report (page 1) Detailed information table for the whole brain, lateral ventricles and thalami Brain structure volume in cc or cm 3 Percent of Intracranial Volume (% of ICV) Structures as they relate to the size of the head Normative Percentile As the structure relates to a normative population of healthy individuals with the same imaging parameters Normative Reference Charts Displays normative percentile in visual form X-axis is Age (years) and Y-axis is Volume (% of ICV) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 12

Multi Structure Atrophy Report (page 2) Report name and clinic site information Patient demographic information Table detailing raw volume, intracranial volume (ICV) percentage and normative percentile of the six structures also listed in the reference charts below Age-matched reference charts for cortical gray matter, cerebral white matter, white matter hypointensities, third ventricle, hippocampi and inferior lateral ventricles September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 13

Multi Structure Atrophy Report (page 2) Detailed information table for the cortical gray and white matter, white matter hypointensities, third ventricle, hippocampus and inferior lateral ventricle Brain structure volume in cc or cm 3 Percent of Intracranial Volume (% of ICV) Structures as they relate to the size of the head Normative Percentile As the structure relates to a normative population of healthy individuals with the same imaging parameters Normative Reference Charts Displays normative percentile in visual form X-axis is Age (years) and Y-axis is Volume (% of ICV) September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 14

Triage Brain Atrophy Report Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing intracranial volume and right and left values for Z-score and normative percentile of ICV of 39 brain structures September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 15

Triage Brain Atrophy Report Intracranial Volume (ICV) Total volume in cc or cm 3, ICV Z-Score and normative percentile Detailed information table for 10 brain structures, basal ganglia, frontal lobe, parietal lobe, occipital lobe, temporal lobe and limbic lobe Left Z-score and normative percentile Right Z-score and normative percentile Z-score A positive Z-score indicates a value above the mean, while a negative Z-score indicates a value below the mean Normative Percentile As the structure relate to a normative population of healthy individuals with the same imaging parameters September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 16

General Morphometry Report Included with all NeuroQuant reports Report name and clinic site information Patient demographic information, with referring physician and exam date Axial, coronal and sagittal brain images Table detailing absolute intracranial volume, as well as right and left volumes (absolute and percent of ICV) and asymmetry index of eleven brain structures September 2015 NeuroQuant - 2015 CorTechs Labs, Inc. 17

Learn more about NeuroQuant www.cortechslabs.com INFO@CORTEC HSLABS.COM +1.858.459.9700 4690 EXECUTIVE DRIVE SUITE 250 SAN DIEGO, CA 92121 USA