Christophe Vieu Toulouse University Chargé de Mission du LAAS Axe Interaction avec le vivant Coupling Engineering Sciences and Life Sciences: An overview of LAAS Activities with a special focus on Nano-Oncology Projects Laboratoire d Analyse et d Architecture des Systèmes
Mobilis in Mobili* LAAS * J.Verne Vingt Mille lieues sous les mers, 1869
ALIVE Interactions with Life sciences and Environment - Oncology : A strategical orientation of LAAS-CNRS
Lab on chips, Micro-Fluidics, Integrated Biodetection
Dosing Biomarkers
In-Vivo communicating sensors Assisting Robots Implantable devices Medical Monitoring
ALIVE Working Groups - WG1: Molecular Engineering - WG2: Cellular Engineering - WG3: Biodetection - WG4: Bio-Inspiration - WG5: Modeling/Data processing - WG6: Applicative Fields
- Single molecule scale manipulations and measurements ( nanochannels,nanopores, single molecule assays) - Diagnostic, sequencing (genetics and epi-genetics investigations) Single stretched DNA molecules transfer-printed on a surface after directed assembly on a microstructured PDMS stamp Stretching of DNA molecules inside nanochannels for epigenetics investigations
- Single Cell manipulation and measurements (AFM, e.m) - Metrology and cell sorting (Fluidics, Imaging, physical discrimination) - Cell/device Interface (cell culture on nanoengineered surfaces, mechanosensing) - Cell/Cell interactions, (Tissue engineering, secretome analysis) Long range alignment of neurites through Micro/Nanaopatterning and control of stem cells differenciation Circular micro-coil, 20 turns, 5µm*5µm*5µm, I=150mA 0s 1s 2s Hydrodynamical and Magnetic Cell sorting devices 3s 4s 5s
«bona diagnosis bona curatio» Ultra high sensibility detection using Micro/nanosystems(FET, M(O)EMS, N(O)EMS, SERS, MEF) Micro/nano fluidics, concentrators Blood engineering In-Vivo communicating biodetection devices A Carbon NEMS detection device obtained by combination of capillary assembly and DEP of Double Walled Carbon Nanotubes (DWCNTs)
- Hybrid (Bio/Artificial) devices (integration of Bionanomachines) - DNA Technologies for Nanofabrication (aptamers, DNA origami, DNA nanochannels) - Bio-assembled materials - Bio-Inspired Motility and cooperation 20 nm AFM Image of the MS-ring assembly of the bacterial flagellar nanomotor on an artifiicial suspended lipidic membrane Directed Assembly of NPs through DNA hybridization
- Atomic Modelling of bio integrated technological processes and molecular interactions: molecular flexibility,ras protein,aptamers, DNA self-assembled nanostructures - Machine learning algorithms for biochip data processing - Modelling from robotics (ligand/receptor inetractions) - Brain Data processing
- A unique site in Europe where an Academic State of the art nanofabrication clean-room facility is coupled with a critical mass of Engineers and Researchers dedicated to life science applications. - An open access policy
Micro Nano fabrication Platform 1500 m2 Clean room class 10 000 to 100 nvestments : 3.5 M (CPER), 14.5 M (BTR).3 M (LAAS), 0.62 M (CA) RENATECH network
- Oncology (Toulouse Oncopole) - Neurosciences - Skin - Food and environmental security - e-medicine
LAAS-CRCT Joined Roadmap * in vivo Engineering: Embedded sensors and fishing tools * ex vivo Engineering: Biodetection and therapy follow-up * Tumoral Micro environment * Genome evolution under stress, therapy induced resistances Institut Universitaire du Cancer, Toulouse Oncopole CRCT: centre de Recherches en Cancérologie de Toulouse CUC: Clinique Universitaire du Cancer * Molecular simulations and BioInfo
* ex vivo Engineering: 8th Cancer Scientific Forum 21 March 2013 Lyon - CLARA
* Molecular simulations and BioInfo 8th Cancer Scientific Forum 21 March 2013 Lyon - CLARA
9 th International NANOBIOEUROPE Conference 10-12 June 2013 http://nanobioeurope2013.sciencesconf.org/
http://nanobioeurope2013.sciencesconf.org/ Special Session on Nano-Oncology organized by CGSO&CLARA Single molecule technology Sensing based nanotechnology Imaging based nanotechnology Nano-objects & nanomaterial for life sciences Nano-enabled drug delivery Nanotechnology for cell characterisation & tissu engineering Nano-Oncology & Nanomedicine Nanotoxicity Scientific contributions presented at NBE2013 conference will be published in a special issue of BioNanoScience Journal
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